                         SEQUENCE LISTING

<110>  Rutgers, The State University of New Jersey
 
<120>  AAV-COMPATIBLE LAMININ-LINKER POLYMERIZATION PROTEINS

<130>  10491/006542-WO0

<150>  62/668,664
<151>  2018-05-08

<160>  170   

<170>  PatentIn version 3.5

<210>  1
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse alphaLNNdDeltaG2 open reading frame no tag used in the AAV 
       construct

<400>  1
atgagggcct ggatcttctt tctcctttgc ctggccggga gggctctggc acagcagaga       60

ggcttgttcc ctgccattct caacctggcc accaatgccc acatcagcgc caatgctacc      120

tgtggagaga aggggcctga gatgttctgc aaactcgtgg agcacgtgcc gggccggcct      180

gttcgacacg cccaatgccg ggtctgtgac ggtaacagta cgaatcctag agagcgccat      240

ccgatatcac acgcaatcga tggcaccaac aactggtggc agagccccag tattcagaat      300

gggagagagt atcactgggt cactgtcacc ctggacttac ggcaggtctt tcaagttgca      360

tacatcatca ttaaagctgc caatgcccct cggcctggaa actggatttt ggagcgctcc      420

gtggatggcg tcaagttcaa accctggcag tactatgccg tcagcgatac agagtgtttg      480

acccgctaca aaataactcc acggcgggga cctcccactt acagagcaga caacgaagtc      540

atctgcacct cgtattattc aaagctggtg ccacttgaac atggagagat tcacacatca      600

ctcatcaatg gcagacccag cgctgacgac ccctcacccc agttgctgga attcacctca      660

gcacggtaca ttcgccttcg tcttcagcgc atcagaacac tcaacgcaga cctcatgacc      720

cttagccatc gggacctcag agaccttgac cccattgtca caagacgtta ttactattcg      780

ataaaagaca tttccgttgg aggcatgtgc atttgctacg gccatgccag cagctgcccg      840

tgggatgaag aagcaaagca actacagtgt cagtgtgaac acaatacgtg tggcgagagc      900

tgcgacaggt gctgtcctgg ctaccatcag cagccctgga ggcccggaac catttcctcc      960

ggcaacgagt gtgaggaatg caactgtcac aacaaagcca aagattgtta ctatgacagc     1020

agtgttgcaa aggagaggag aagcctgaac actgccgggc agtacagtgg aggaggggtt     1080

tgtgtcaact gctcgcagaa taccacaggg atcaactgtg aaacctgtat cgaccagtat     1140

tacagacctc acaaggtatc tccttatgat gaccaccctt gccgtccctg taactgtgac     1200

cctgtggggt ctctgagttc tgtctgtatc aaggatgacc gccatgccga tttagccaat     1260

ggaaagtggc caggtcagtg tccatgtagg aaaggttatg ctggagataa atgtgaccgc     1320

tgccagtttg gctaccgggg tttcccaaat tgcatcccct gtgactgcag gactgtcggc     1380

agcctgaatg aggatccatg catagagccg tgtctttgta agaaaaatgt tgagggtaag     1440

aactgtgatc gctgcaagcc aggattctac aacttgaagg aacgaaaccc cgagggctgc     1500

tccgagtgct tctgcttcgg tgtctctggt gtctgtccca tcaactactg tgaaactggt     1560

ctccacaact gtgatatccc ccagcgagcc cagtgcatct atatgggtgg ttcctcctac     1620

acctgctcct gtctgcctgg cttctctggg gatggcagag cctgccgaga cgtggatgaa     1680

tgccagcaca gccgatgtca ccccgatgcc ttctgctaca acacaccagg ctctttcaca     1740

tgtcagtgca agcctggcta tcagggggat ggcttccgat gcatgcccgg agaggtgagc     1800

aaaacccggt gtcaactgga acgagagcac atccttggag cagccggcgg ggcagatgca     1860

cagcggccca ccctgcaggg gatgtttgtg cctcagtgtg atgaatatgg acactatgta     1920

cccacccagt gtcaccacag cactggctac tgctggtgtg tggaccgaga tggtcgggag     1980

ctggagggta gccgtacccc acctgggatg aggcccccgt gtctgagtac agtggctcct     2040

cctattcacc agggaccagt agtacctaca gctgtcatcc ccctgcctcc agggacacac     2100

ttactctttg ctcagactgg aaagattgaa cgcctgcccc tggaaagaaa caccatgaag     2160

aagacagaac gcaaggcctt tctccatatc cctgcaaaag tcatcattgg actggccttt     2220

gactgcgtgg acaaggtggt ttactggaca gacatcagcg agccttccat tgggagagcc     2280

agcctccacg gtggagagcc aaccaccatc attcgacaag atcttggaag ccctgaaggc     2340

attgcccttg accatcttgg tcgaaccatc ttctggacgg actctcagtt ggatcgaata     2400

gaagttgcaa agatggatgg cacccagcgc cgagtgctgt ttgacacggg tttggtgaat     2460

cccagaggca ttgtgacaga ccccgtaaga gggaaccttt attggacaga ttggaacaga     2520

gataatccca aaattgagac ttctcacatg gatggcacca accggaggat tctcgcacag     2580

gacaacctgg gcttgcccaa tggtctgacc tttgatgcat tctcatctca gctttgctgg     2640

gtggatgcag gcacccatag ggcagaatgc ctgaacccag ctcagcctgg cagacgcaaa     2700

gttctcgaag ggctccagta tcctttcgct gtgactagct atgggaagaa tttgtactac     2760

acagactgga agacgaattc agtgattgcc atggaccttg ctatatccaa agagatggat     2820

accttccacc cacacaagca gacccggcta tatggcatca ccatcgccct gtcccagtgt     2880

ccccaaggcc acaattactg ctcagtgaat aatggtggat gtacccacct ctgcttgccc     2940

actccaggga gcaggacctg ccgatgtcct gacaacaccc tgggagttga ctgcattgaa     3000

cggaaatga                                                             3009


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F1noG2 1F

<400>  2
ctgggtcact gtcaccctgg                                                   20


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  noG2 2R

<400>  3
atggattctg aagacagaca ccagagacac                                        30


<210>  4
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  no G2 2F

<400>  4
ctggtgtctg tcttcagaat ccatgctac                                         29


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F1 no G2 1R

<400>  5
gaaggcacag tcgaggctga tcag                                              24


<210>  6
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bam shnoG2 1F

<400>  6
cggcagcctg aatgaggatc catgcataga                                        30


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shnoG2 2R

<400>  7
cacagtagtt gatgggacag acacc                                             25


<210>  8
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shnoG2 2F

<400>  8
gtctctggtg tctgtcccat caacta                                            26


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequencce

<220>
<223>  sse shnoG2 1R

<400>  9
gaggcacaaa catcccctgc agggtgggcc                                        30


<210>  10
<211>  4639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-MCS Expression Vector

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggagct agttattaat agtaatcaat tacggggtca      180

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      240

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      300

acgtcaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac      360

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      420

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      480

tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat      540

gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat      600

gggagtttgt tttgcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc      660

cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt      720

tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac      780

accgggaccg atccagcctc cgcggattcg aatcccggcc gggaacggtg cattggaacg      840

cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag gcccacaaaa      900

aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact ttccctaatc      960

tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca ttctaaagaa     1020

taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc     1080

atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta     1140

ccattctgct tttattttat ggttgggata aggctggatt attctgagtc caagctaggc     1200

ccttttgcta atcatgttca tacctcttat cttcctccca cagctcctgg gcaacgtgct     1260

ggtctgtgtg ctggcccatc actttggcaa agaattggga ttcgaacatc gattgaattc     1320

cccggggatc ctctagagtc gacctgcaga agcttgcctc gagcagcgct gctcgagaga     1380

tctacgggtg gcatccctgt gacccctccc cagtgcctct cctggccctg gaagttgcca     1440

ctccagtgcc caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg     1500

tgtccttcta taatattatg gggtggaggg gggtggtatg gagcaagggg caagttggga     1560

agacaacctg tagggcctgc ggggtctatt gggaaccaag ctggagtgca gtggcacaat     1620

cttggctcac tgcaatctcc gcctcctggg ttcaagcgat tctcctgcct cagcctcccg     1680

agttgttggg attccaggca tgcatgacca ggctcagcta atttttgttt ttttggtaga     1740

gacggggttt caccatattg gccaggctgg tctccaactc ctaatctcag gtgatctacc     1800

caccttggcc tcccaaattg ctgggattac aggcgtgaac cactgctccc ttccctgtcc     1860

ttctgatttt gtaggtaacc acgtgcggac cgagcggccg caggaacccc tagtgatgga     1920

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     1980

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     2040

ggggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg     2100

tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     2160

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     2220

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     2280

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat     2340

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     2400

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcgggc     2460

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     2520

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat tttatggtgc     2580

actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca     2640

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg     2700

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga     2760

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct     2820

tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     2880

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     2940

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     3000

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     3060

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc     3120

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta     3180

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac     3240

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc     3300

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac     3360

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg     3420

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac     3480

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc     3540

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt     3600

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga     3660

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc     3720

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag     3780

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca     3840

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc     3900

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     3960

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     4020

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     4080

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt     4140

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     4200

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     4260

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     4320

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     4380

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     4440

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     4500

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     4560

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     4620

tggccttttg ctcacatgt                                                  4639


<210>  11
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  11
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  12
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV Promoter

<400>  12
acgcgtggag ctagttatta atagtaatca attacggggt cattagttca tagcccatat       60

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac      120

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgtcaat agggactttc      180

cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg      240

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat      300

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc      360

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt      420

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttgcacc      480

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      540

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      600

cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc      660

tcc                                                                    663


<210>  13
<211>  493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta globin Intron

<400>  13
cgaatcccgg ccgggaacgg tgcattggaa cgcggattcc ccgtgccaag agtgacgtaa       60

gtaccgccta tagagtctat aggcccacaa aaaatgcttt cttcttttaa tatacttttt      120

tgtttatctt atttctaata ctttccctaa tctctttctt tcagggcaat aatgatacaa      180

tgtatcatgc ctctttgcac cattctaaag aataacagtg ataatttctg ggttaaggca      240

atagcaatat ttctgcatat aaatatttct gcatataaat tgtaactgat gtaagaggtt      300

tcatattgct aatagcagct acaatccagc taccattctg cttttatttt atggttggga      360

taaggctgga ttattctgag tccaagctag gcccttttgc taatcatgtt catacctctt      420

atcttcctcc cacagctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc      480

aaagaattgg gat                                                         493


<210>  14
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCS

<400>  14
atcgattgaa ttccccgggg atcctctaga gtcgacctgc agaagcttgc ctcgagcagc       60

gctgctcgag agatct                                                       76


<210>  15
<211>  479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PolyA

<400>  15
acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa gttgccactc       60

cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct gactaggtgt      120

ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa gttgggaaga      180

caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg gcacaatctt      240

ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag cctcccgagt      300

tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt tggtagagac      360

ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg atctacccac      420

cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc cctgtcctt       479


<210>  16
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  16
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  17
<211>  7333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-DJ Vector

<400>  17
ccgccatgcc ggggttttac gagattgtga ttaaggtccc cagcgacctt gacgagcatc       60

tgcccggcat ttctgacagc tttgtgaact gggtggccga gaaggaatgg gagttgccgc      120

cagattctga catggatctg aatctgattg agcaggcacc cctgaccgtg gccgagaagc      180

tgcagcgcga ctttctgacg gaatggcgcc gtgtgagtaa ggccccggag gcccttttct      240

ttgtgcaatt tgagaaggga gagagctact tccacatgca cgtgctcgtg gaaaccaccg      300

gggtgaaatc catggttttg ggacgtttcc tgagtcagat tcgcgaaaaa ctgattcaga      360

gaatttaccg cgggatcgag ccgactttgc caaactggtt cgcggtcaca aagaccagaa      420

atggcgccgg aggcgggaac aaggtggtgg atgagtgcta catccccaat tacttgctcc      480

ccaaaaccca gcctgagctc cagtgggcgt ggactaatat ggaacagtat ttaagcgcct      540

gtttgaatct cacggagcgt aaacggttgg tggcgcagca tctgacgcac gtgtcgcaga      600

cgcaggagca gaacaaagag aatcagaatc ccaattctga tgcgccggtg atcagatcaa      660

aaacttcagc caggtacatg gagctggtcg ggtggctcgt ggacaagggg attacctcgg      720

agaagcagtg gatccaggag gaccaggcct catacatctc cttcaatgcg gcctccaact      780

cgcggtccca aatcaaggct gccttggaca atgcgggaaa gattatgagc ctgactaaaa      840

ccgcccccga ctacctggtg ggccagcagc ccgtggagga catttccagc aatcggattt      900

ataaaatttt ggaactaaac gggtacgatc cccaatatgc ggcttccgtc tttctgggat      960

gggccacgaa aaagttcggc aagaggaaca ccatctggct gtttgggcct gcaactaccg     1020

ggaagaccaa catcgcggag gccatagccc acactgtgcc cttctacggg tgcgtaaact     1080

ggaccaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatc tggtgggagg     1140

aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg     1200

tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga cccgactccc gtgatcgtca     1260

cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc     1320

agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg     1380

ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg     1440

aggtggagca tgaattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccccagtg     1500

acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcag     1560

acgcggaagc ttcgatcaac tacgcagaca ggtaccaaaa caaatgttct cgtcacgtgg     1620

gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcag aattcaaata     1680

tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac     1740

ccgtttctgt cgtcaaaaag gcgtatcaga aactgtgcta cattcatcat atcatgggaa     1800

aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct     1860

ttgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc     1920

gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca     1980

ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc tgggtacaag     2040

tacctcggac ccttcaacgg actcgacaag ggagagccgg tcaacgaggc agacgccgcg     2100

gccctcgagc acgacaaagc ctacgaccgg cagctcgaca gcggagacaa cccgtacctc     2160

aagtacaacc acgccgacgc cgagttccag gagcggctca aagaagatac gtcttttggg     2220

ggcaacctcg ggcgagcagt cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg     2280

gttgaggaag cggctaagac ggctcctgga aagaagaggc ctgtagagca ctctcctgtg     2340

gagccagact cctcctcggg aaccggaaag gcgggccagc agcctgcaag aaaaagattg     2400

aattttggtc agactggaga cgcagactca gtcccagacc ctcaaccaat cggagaacct     2460

cccgcagccc cctcaggtgt gggatctctt acaatggctg caggcggtgg cgcaccaatg     2520

gcagacaata acgagggcgc cgacggagtg ggtaattcct cgggaaattg gcattgcgat     2580

tccacatgga tgggcgacag agtcatcacc accagcaccc gaacctgggc cctgcccacc     2640

tacaacaacc acctctacaa gcaaatctcc aacagcacat ctggaggatc ttcaaatgac     2700

aacgcctact tcggctacag caccccctgg gggtattttg actttaacag attccactgc     2760

cacttttcac cacgtgactg gcagcgactc atcaacaaca actggggatt ccggcccaag     2820

agactcagct tcaagctctt caacatccag gtcaaggagg tcacgcagaa tgaaggcacc     2880

aagaccatcg ccaataacct caccagcacc atccaggtgt ttacggactc ggagtaccag     2940

ctgccgtacg ttctcggctc tgcccaccag ggctgcctgc ctccgttccc ggcggacgtg     3000

ttcatgattc cccagtacgg ctacctaaca ctcaacaacg gtagtcaggc cgtgggacgc     3060

tcctccttct actgcctgga atactttcct tcgcagatgc tgagaaccgg caacaacttc     3120

cagtttactt acaccttcga ggacgtgcct ttccacagca gctacgccca cagccagagc     3180

ttggaccggc tgatgaatcc tctgattgac cagtacctgt actacttgtc tcggactcaa     3240

acaacaggag gcacgacaaa tacgcagact ctgggcttca gccaaggtgg gcctaataca     3300

atggccaatc aggcaaagaa ctggctgcca ggaccctgtt accgccagca gcgagtatca     3360

aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac caagtaccac     3420

ctcaatggca gagactctct ggtgaatccg ggcccggcca tggcaagcca caaggacgat     3480

gaagaaaagt tttttcctca gagcggggtt ctcatctttg ggaagcaagg ctcagagaaa     3540

acaaatgtgg acattgaaaa ggtcatgatt acagacgaag aggaaatcag gacaaccaat     3600

cccgtggcta cggagcagta tggttctgta tctaccaacc tccagagagg caacagacaa     3660

gcagctaccg cagatgtcaa cacacaaggc gttcttccag gcatggtctg gcaggacaga     3720

gatgtgtacc ttcaggggcc catctgggca aagattccac acacggacgg acattttcac     3780

ccctctcccc tcatgggtgg attcggactt aaacaccctc cgcctcagat cctgatcaag     3840

aacacgcctg tacctgcgga tcctccgacc accttcaacc agtcaaagct gaactctttc     3900

atcacccagt attctactgg ccaagtcagc gtggagatcg agtgggagct gcagaaggaa     3960

aacagcaagc gctggaaccc cgagatccag tacacctcca actactacaa atctacaagt     4020

gtggactttg ctgttaatac agaaggcgtg tactctgaac cccgccccat tggcacccgt     4080

tacctcaccc gtaatctgta attgcctgtt aatcaataaa ccggttgatt cgtttcagtt     4140

gaactttggt ctctgcgaag ggcgaattcg tttaaacctg caggactaga ggtcctgtat     4200

tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg ctgggtattt     4260

aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac gcgcagccgc     4320

caagccgaat tctgcagata tccatcacac tggcggccgc tcgactagag cggccgccac     4380

cgcggtggag ctccagcttt tgttcccttt agtgagggtt aattgcgcgc ttggcgtaat     4440

catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac     4500

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     4560

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     4620

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc     4680

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg     4740

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag     4800

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     4860

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     4920

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     4980

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     5040

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     5100

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     5160

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     5220

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     5280

ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     5340

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     5400

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     5460

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     5520

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     5580

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     5640

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     5700

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     5760

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     5820

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     5880

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     5940

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     6000

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     6060

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     6120

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     6180

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     6240

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     6300

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     6360

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     6420

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     6480

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     6540

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctaaat     6600

tgtaagcgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt     6660

taaccaatag gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg     6720

gttgagtgtt gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt     6780

caaagggcga aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc     6840

aagttttttg gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg     6900

atttagagct tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa     6960

aggagcgggc gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc     7020

cgccgcgctt aatgcgccgc tacagggcgc gtcccattcg ccattcaggc tgcgcaactg     7080

ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg     7140

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac     7200

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta ccgggccccc     7260

cctcgatcga ggtcgacggt atcgggggag ctcgcagggt ctccattttg aagcgggagg     7320

tttgaacgcg cag                                                        7333


<210>  18
<211>  1866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-2 Rep gene

<400>  18
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caataa                                                                1866


<210>  19
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-DJ Cap gene

<400>  19
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210>  20
<211>  11635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHelper Vector

<400>  20
ggtacccaac tccatgctta acagtcccca ggtacagccc accctgcgtc gcaaccagga       60

acagctctac agcttcctgg agcgccactc gccctacttc cgcagccaca gtgcgcagat      120

taggagcgcc acttcttttt gtcacttgaa aaacatgtaa aaataatgta ctaggagaca      180

ctttcaataa aggcaaatgt ttttatttgt acactctcgg gtgattattt accccccacc      240

cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct atgcgccact      300

ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg cacaaccatc      360

cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa cgcgtttagc      420

aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc gcgcgagttg      480

cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac gctggccagc      540

acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag ggcgaacgga      600

gtcaactttg gtagctgcct tcccaaaaag ggtgcatgcc caggctttga gttgcactcg      660

caccgtagtg gcatcagaag gtgaccgtgc ccggtctggg cgttaggata cagcgcctgc      720

atgaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga gaagaacatg      780

ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcatgcac gcagcacctt      840

gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac gatcttggcc      900

ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc catttcaatc      960

acgtgctcct tatttatcat aatgctcccg tgtagacact taagctcgcc ttcgatctca     1020

gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt ggtgcttgta ggttacctct     1080

gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa ggtcttgttg     1140

ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttta gccaggtctt gcatacggcc     1200

gccagagctt ccacttggtc aggcagtagc ttgaagtttg cctttagatc gttatccacg     1260

tggtacttgt ccatcaacgc gcgcgcagcc tccatgccct tctcccacgc agacacgatc     1320

ggcaggctca gcgggtttat caccgtgctt tcactttccg cttcactgga ctcttccttt     1380

tcctcttgcg tccgcatacc ccgcgccact gggtcgtctt cattcagccg ccgcaccgtg     1440

cgcttacctc ccttgccgtg cttgattagc accggtgggt tgctgaaacc caccatttgt     1500

agcgccacat cttctctttc ttcctcgctg tccacgatca cctctgggga tggcgggcgc     1560

tcgggcttgg gagaggggcg cttctttttc tttttggacg caatggccaa atccgccgtc     1620

gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg catcttgtga cgagtcttct     1680

tcgtcctcgg actcgagacg ccgcctcagc cgcttttttg ggggcgcgcg gggaggcggc     1740

ggcgacggcg acggggacga cacgtcctcc atggttggtg gacgtcgcgc cgcaccgcgt     1800

ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc cttctcctat     1860

aggcagaaaa agatcatgga gtcagtcgag aaggaggaca gcctaaccgc cccctttgag     1920

ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc cgtcgaggca     1980

cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt aagcgaagac     2040

gacgaggatc gctcagtacc aacagaggat aaaaagcaag accaggacga cgcagaggca     2100

aacgaggaac aagtcgggcg gggggaccaa aggcatggcg actacctaga tgtgggagac     2160

gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc gttgcaagag     2220

cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg ccacctgttc     2280

tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa cccgcgcctc     2340

aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat ctttttccaa     2400

aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa gcagctggcc     2460

ttgcggcagg gcgctgtcat acctgatatc gcctcgctcg acgaagtgcc aaaaatcttt     2520

gagggtcttg gacgcgacga gaaacgcgcg gcaaacgctc tgcaacaaga aaacagcgaa     2580

aatgaaagtc actgtggagt gctggtggaa cttgagggtg acaacgcgcg cctagccgtg     2640

ctgaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct accccccaag     2700

gttatgagca cagtcatgag cgagctgatc gtgcgccgtg cacgacccct ggagagggat     2760

gcaaacttgc aagaacaaac cgaggagggc ctacccgcag ttggcgatga gcagctggcg     2820

cgctggcttg agacgcgcga gcctgccgac ttggaggagc gacgcaagct aatgatggcc     2880

gcagtgcttg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga cccggagatg     2940

cagcgcaagc tagaggaaac gttgcactac acctttcgcc agggctacgt gcgccaggcc     3000

tgcaaaattt ccaacgtgga gctctgcaac ctggtctcct accttggaat tttgcacgaa     3060

aaccgcctcg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg ccgcgactac     3120

gtccgcgact gcgtttactt atttctgtgc tacacctggc aaacggccat gggcgtgtgg     3180

cagcaatgcc tggaggagcg caacctaaag gagctgcaga agctgctaaa gcaaaacttg     3240

aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc ggacattatc     3300

ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac cagtcaaagc     3360

atgttgcaaa actttaggaa ctttatccta gagcgttcag gaattctgcc cgccacctgc     3420

tgtgcgcttc ctagcgactt tgtgcccatt aagtaccgtg aatgccctcc gccgctttgg     3480

ggtcactgct accttctgca gctagccaac taccttgcct accactccga catcatggaa     3540

gacgtgagcg gtgacggcct actggagtgt cactgtcgct gcaacctatg caccccgcac     3600

cgctccctgg tctgcaattc gcaactgctt agcgaaagtc aaattatcgg tacctttgag     3660

ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact cactccgggg     3720

ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc ccacgagatt     3780

aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg cgtcattacc     3840

cagggccaca tccttggcca attgcaagcc atcaacaaag cccgccaaga gtttctgcta     3900

cgaaagggac ggggggttta cctggacccc cagtccggcg aggagctcaa cccaatcccc     3960

ccgccgccgc agccctatca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa     4020

gaagctgcag ctgccgccgc cgccacccac ggacgaggag gaatactggg acagtcaggc     4080

agaggaggtt ttggacgagg aggaggagat gatggaagac tgggacagcc tagacgaagc     4140

ttccgaggcc gaagaggtgt cagacgaaac accgtcaccc tcggtcgcat tcccctcgcc     4200

ggcgccccag aaattggcaa ccgttcccag catcgctaca acctccgctc ctcaggcgcc     4260

gccggcactg cctgttcgcc gacccaaccg tagatgggac accactggaa ccagggccgg     4320

taagtctaag cagccgccgc cgttagccca agagcaacaa cagcgccaag gctaccgctc     4380

gtggcgcggg cacaagaacg ccatagttgc ttgcttgcaa gactgtgggg gcaacatctc     4440

cttcgcccgc cgctttcttc tctaccatca cggcgtggcc ttcccccgta acatcctgca     4500

ttactaccgt catctctaca gcccctactg caccggcggc agcggcagcg gcagcaacag     4560

cagcggtcac acagaagcaa aggcgaccgg atagcaagac tctgacaaag cccaagaaat     4620

ccacagcggc ggcagcagca ggaggaggag cgctgcgtct ggcgcccaac gaacccgtat     4680

cgacccgcga gcttagaaat aggatttttc ccactctgta tgctatattt caacaaagca     4740

ggggccaaga acaagagctg aaaataaaaa acaggtctct gcgctccctc acccgcagct     4800

gcctgtatca caaaagcgaa gatcagcttc ggcgcacgct ggaagacgcg gaggctctct     4860

tcagcaaata ctgcgcgctg actcttaagg actagtttcg cgccctttct caaatttaag     4920

cgcgaaaact acgtcatctc cagcggccac acccggcgcc agcacctgtc gtcagcgcca     4980

ttatgagcaa ggaaattccc acgccctaca tgtggagtta ccagccacaa atgggacttg     5040

cggctggagc tgcccaagac tactcaaccc gaataaacta catgagcgcg ggaccccaca     5100

tgatatcccg ggtcaacgga atccgcgccc accgaaaccg aattctcctc gaacaggcgg     5160

ctattaccac cacacctcgt aataacctta atccccgtag ttggcccgct gccctggtgt     5220

accaggaaag tcccgctccc accactgtgg tacttcccag agacgcccag gccgaagttc     5280

agatgactaa ctcaggggcg cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg     5340

ggcgttttag ggcggagtaa cttgcatgta ttgggaattg tagttttttt aaaatgggaa     5400

gtgacgtatc gtgggaaaac ggaagtgaag atttgaggaa gttgtgggtt ttttggcttt     5460

cgtttctggg cgtaggttcg cgtgcggttt tctgggtgtt ttttgtggac tttaaccgtt     5520

acgtcatttt ttagtcctat atatactcgc tctgtacttg gcccttttta cactgtgact     5580

gattgagctg gtgccgtgtc gagtggtgtt ttttaatagg tttttttact ggtaaggctg     5640

actgttatgg ctgccgctgt ggaagcgctg tatgttgttc tggagcggga gggtgctatt     5700

ttgcctaggc aggagggttt ttcaggtgtt tatgtgtttt tctctcctat taattttgtt     5760

atacctccta tgggggctgt aatgttgtct ctacgcctgc gggtatgtat tcccccgggc     5820

tatttcggtc gctttttagc actgaccgat gttaaccaac ctgatgtgtt taccgagtct     5880

tacattatga ctccggacat gaccgaggaa ctgtcggtgg tgctttttaa tcacggtgac     5940

cagttttttt acggtcacgc cggcatggcc gtagtccgtc ttatgcttat aagggttgtt     6000

tttcctgttg taagacaggc ttctaatgtt taaatgtttt tttttttgtt attttatttt     6060

gtgtttaatg caggaacccg cagacatgtt tgagagaaaa atggtgtctt tttctgtggt     6120

ggttccggaa cttacctgcc tttatctgca tgagcatgac tacgatgtgc ttgctttttt     6180

gcgcgaggct ttgcctgatt ttttgagcag caccttgcat tttatatcgc cgcccatgca     6240

acaagcttac ataggggcta cgctggttag catagctccg agtatgcgtg tcataatcag     6300

tgtgggttct tttgtcatgg ttcctggcgg ggaagtggcc gcgctggtcc gtgcagacct     6360

gcacgattat gttcagctgg ccctgcgaag ggacctacgg gatcgcggta tttttgttaa     6420

tgttccgctt ttgaatctta tacaggtctg tgaggaacct gaatttttgc aatcatgatt     6480

cgctgcttga ggctgaaggt ggagggcgct ctggagcaga tttttacaat ggccggactt     6540

aatattcggg atttgcttag agacatattg ataaggtggc gagatgaaaa ttatttgggc     6600

atggttgaag gtgctggaat gtttatagag gagattcacc ctgaagggtt tagcctttac     6660

gtccacttgg acgtgagggc agtttgcctt ttggaagcca ttgtgcaaca tcttacaaat     6720

gccattatct gttctttggc tgtagagttt gaccacgcca ccggagggga gcgcgttcac     6780

ttaatagatc ttcattttga ggttttggat aatcttttgg aataaaaaaa aaaaaacatg     6840

gttcttccag ctcttcccgc tcctcccgtg tgtgactcgc agaacgaatg tgtaggttgg     6900

ctgggtgtgg cttattctgc ggtggtggat gttatcaggg cagcggcgca tgaaggagtt     6960

tacatagaac ccgaagccag ggggcgcctg gatgctttga gagagtggat atactacaac     7020

tactacacag agcgagctaa gcgacgagac cggagacgca gatctgtttg tcacgcccgc     7080

acctggtttt gcttcaggaa atatgactac gtccggcgtt ccatttggca tgacactacg     7140

accaacacga tctcggttgt ctcggcgcac tccgtacagt agggatcgcc tacctccttt     7200

tgagacagag acccgcgcta ccatactgga ggatcatccg ctgctgcccg aatgtaacac     7260

tttgacaatg cacaacgtga gttacgtgcg aggtcttccc tgcagtgtgg gatttacgct     7320

gattcaggaa tgggttgttc cctgggatat ggttctgacg cgggaggagc ttgtaatcct     7380

gaggaagtgt atgcacgtgt gcctgtgttg tgccaacatt gatatcatga cgagcatgat     7440

gatccatggt tacgagtcct gggctctcca ctgtcattgt tccagtcccg gttccctgca     7500

gtgcatagcc ggcgggcagg ttttggccag ctggtttagg atggtggtgg atggcgccat     7560

gtttaatcag aggtttatat ggtaccggga ggtggtgaat tacaacatgc caaaagaggt     7620

aatgtttatg tccagcgtgt ttatgagggg tcgccactta atctacctgc gcttgtggta     7680

tgatggccac gtgggttctg tggtccccgc catgagcttt ggatacagcg ccttgcactg     7740

tgggattttg aacaatattg tggtgctgtg ctgcagttac tgtgctgatt taagtgagat     7800

cagggtgcgc tgctgtgccc ggaggacaag gcgtctcatg ctgcgggcgg tgcgaatcat     7860

cgctgaggag accactgcca tgttgtattc ctgcaggacg gagcggcggc ggcagcagtt     7920

tattcgcgcg ctgctgcagc accaccgccc tatcctgatg cacgattatg actctacccc     7980

catgtaggcg tggacttccc cttcgccgcc cgttgagcaa ccgcaagttg gacagcagcc     8040

tgtggctcag cagctggaca gcgacatgaa cttaagcgag ctgcccgggg agtttattaa     8100

tatcactgat gagcgtttgg ctcgacagga aaccgtgtgg aatataacac ctaagaatat     8160

gtctgttacc catgatatga tgctttttaa ggccagccgg ggagaaagga ctgtgtactc     8220

tgtgtgttgg gagggaggtg gcaggttgaa tactagggtt ctgtgagttt gattaaggta     8280

cggtgatcaa tataagctat gtggtggtgg ggctatacta ctgaatgaaa aatgacttga     8340

aattttctgc aattgaaaaa taaacacgtt gaaacataac atgcaacagg ttcacgattc     8400

tttattcctg ggcaatgtag gagaaggtgt aagagttggt agcaaaagtt tcagtggtgt     8460

attttccact ttcccaggac catgtaaaag acatagagta agtgcttacc tcgctagttt     8520

ctgtggattc actagaatcg atgtaggatg ttgcccctcc tgacgcggta ggagaagggg     8580

agggtgccct gcatgtctgc cgctgctctt gctcttgccg ctgctgagga ggggggcgca     8640

tctgccgcag caccggatgc atctgggaaa agcaaaaaag gggctcgtcc ctgtttccgg     8700

aggaatttgc aagcggggtc ttgcatgacg gggaggcaaa cccccgttcg ccgcagtccg     8760

gccggcccga gactcgaacc gggggtcctg cgactcaacc cttggaaaat aaccctccgg     8820

ctacagggag cgagccactt aatgctttcg ctttccagcc taaccgctta cgccgcgcgc     8880

ggccagtggc caaaaaagct agcgcagcag ccgccgcgcc tggaaggaag ccaaaaggag     8940

cgctcccccg ttgtctgacg tcgcacacct gggttcgaca cgcgggcggt aaccgcatgg     9000

atcacggcgg acggccggat ccggggttcg aaccccggtc gtccgccatg atacccttgc     9060

gaatttatcc accagaccac ggaagagtgc ccgcttacag gctctccttt tgcacggtct     9120

agagcgtcaa cgactgcgca cgcctcaccg gccagagcgt cccgaccatg gagcactttt     9180

tgccgctgcg caacatctgg aaccgcgtcc gcgactttcc gcgcgcctcc accaccgccg     9240

ccggcatcac ctggatgtcc aggtacatct acggattacg tcgacgttta aaccatatga     9300

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag     9360

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     9420

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     9480

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     9540

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     9600

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     9660

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     9720

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     9780

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     9840

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     9900

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     9960

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct    10020

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg    10080

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt    10140

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt    10200

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc    10260

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg    10320

cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc    10380

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg    10440

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca    10500

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga    10560

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct    10620

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg    10680

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca    10740

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata    10800

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct    10860

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact    10920

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa    10980

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc    11040

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga    11100

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga    11160

aaagtgccac ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt    11220

aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag    11280

aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga    11340

acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg    11400

aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc    11460

ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg    11520

aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc    11580

gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgatg gatcc         11635


<210>  21
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse alphaLNNdDeltaG2

<400>  21

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Gln Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Thr Asn 
            20                  25                  30          


Ala His Ile Ser Ala Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg His Ala 
    50                  55                  60                  


Gln Cys Arg Val Cys Asp Gly Asn Ser Thr Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Val Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Ile Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Val Asp Gly Val 
    130                 135                 140                 


Lys Phe Lys Pro Trp Gln Tyr Tyr Ala Val Ser Asp Thr Glu Cys Leu 
145                 150                 155                 160 


Thr Arg Tyr Lys Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asn Glu Val Ile Cys Thr Ser Tyr Tyr Ser Lys Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Pro Ser Pro Gln Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Asp Leu Arg Asp Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Glu Ala Lys Gln Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asp Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Ile Ser Ser 
305                 310                 315                 320 


Gly Asn Glu Cys Glu Glu Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Ser Ser Val Ala Lys Glu Arg Arg Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Tyr Ser Gly Gly Gly Val Cys Val Asn Cys Ser Gln Asn Thr 
        355                 360                 365             


Thr Gly Ile Asn Cys Glu Thr Cys Ile Asp Gln Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Asp Asp His Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Arg His Ala 
                405                 410                 415     


Asp Leu Ala Asn Gly Lys Trp Pro Gly Gln Cys Pro Cys Arg Lys Gly 
            420                 425                 430         


Tyr Ala Gly Asp Lys Cys Asp Arg Cys Gln Phe Gly Tyr Arg Gly Phe 
        435                 440                 445             


Pro Asn Cys Ile Pro Cys Asp Cys Arg Thr Val Gly Ser Leu Asn Glu 
    450                 455                 460                 


Asp Pro Cys Ile Glu Pro Cys Leu Cys Lys Lys Asn Val Glu Gly Lys 
465                 470                 475                 480 


Asn Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Arg Asn 
                485                 490                 495     


Pro Glu Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Gly Val Cys 
            500                 505                 510         


Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn Cys Asp Ile Pro Gln 
        515                 520                 525             


Arg Ala Gln Cys Ile Tyr Met Gly Gly Ser Ser Tyr Thr Cys Ser Cys 
    530                 535                 540                 


Leu Pro Gly Phe Ser Gly Asp Gly Arg Ala Cys Arg Asp Val Asp Glu 
545                 550                 555                 560 


Cys Gln His Ser Arg Cys His Pro Asp Ala Phe Cys Tyr Asn Thr Pro 
                565                 570                 575     


Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr Gln Gly Asp Gly Phe 
            580                 585                 590         


Arg Cys Met Pro Gly Glu Val Ser Lys Thr Arg Cys Gln Leu Glu Arg 
        595                 600                 605             


Glu His Ile Leu Gly Ala Ala Gly Gly Ala Asp Ala Gln Arg Pro Thr 
    610                 615                 620                 


Leu Gln Gly Met Phe Val Pro Gln Cys Asp Glu Tyr Gly His Tyr Val 
625                 630                 635                 640 


Pro Thr Gln Cys His His Ser Thr Gly Tyr Cys Trp Cys Val Asp Arg 
                645                 650                 655     


Asp Gly Arg Glu Leu Glu Gly Ser Arg Thr Pro Pro Gly Met Arg Pro 
            660                 665                 670         


Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His Gln Gly Pro Val Val 
        675                 680                 685             


Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr His Leu Leu Phe Ala 
    690                 695                 700                 


Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu Arg Asn Thr Met Lys 
705                 710                 715                 720 


Lys Thr Glu Arg Lys Ala Phe Leu His Ile Pro Ala Lys Val Ile Ile 
                725                 730                 735     


Gly Leu Ala Phe Asp Cys Val Asp Lys Val Val Tyr Trp Thr Asp Ile 
            740                 745                 750         


Ser Glu Pro Ser Ile Gly Arg Ala Ser Leu His Gly Gly Glu Pro Thr 
        755                 760                 765             


Thr Ile Ile Arg Gln Asp Leu Gly Ser Pro Glu Gly Ile Ala Leu Asp 
    770                 775                 780                 


His Leu Gly Arg Thr Ile Phe Trp Thr Asp Ser Gln Leu Asp Arg Ile 
785                 790                 795                 800 


Glu Val Ala Lys Met Asp Gly Thr Gln Arg Arg Val Leu Phe Asp Thr 
                805                 810                 815     


Gly Leu Val Asn Pro Arg Gly Ile Val Thr Asp Pro Val Arg Gly Asn 
            820                 825                 830         


Leu Tyr Trp Thr Asp Trp Asn Arg Asp Asn Pro Lys Ile Glu Thr Ser 
        835                 840                 845             


His Met Asp Gly Thr Asn Arg Arg Ile Leu Ala Gln Asp Asn Leu Gly 
    850                 855                 860                 


Leu Pro Asn Gly Leu Thr Phe Asp Ala Phe Ser Ser Gln Leu Cys Trp 
865                 870                 875                 880 


Val Asp Ala Gly Thr His Arg Ala Glu Cys Leu Asn Pro Ala Gln Pro 
                885                 890                 895     


Gly Arg Arg Lys Val Leu Glu Gly Leu Gln Tyr Pro Phe Ala Val Thr 
            900                 905                 910         


Ser Tyr Gly Lys Asn Leu Tyr Tyr Thr Asp Trp Lys Thr Asn Ser Val 
        915                 920                 925             


Ile Ala Met Asp Leu Ala Ile Ser Lys Glu Met Asp Thr Phe His Pro 
    930                 935                 940                 


His Lys Gln Thr Arg Leu Tyr Gly Ile Thr Ile Ala Leu Ser Gln Cys 
945                 950                 955                 960 


Pro Gln Gly His Asn Tyr Cys Ser Val Asn Asn Gly Gly Cys Thr His 
                965                 970                 975     


Leu Cys Leu Pro Thr Pro Gly Ser Arg Thr Cys Arg Cys Pro Asp Asn 
            980                 985                 990         


Thr Leu Gly Val Asp Cys Ile Glu  Arg Lys 
        995                 1000         


<210>  22
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human shNoG2 amino acid sequence; Human alphaLNNDdDeltaG2

<400>  22

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn 
            20                  25                  30          


Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro 
    50                  55                  60                  


Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr 
    130                 135                 140                 


Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser 
305                 310                 315                 320 


Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr 
        355                 360                 365             


Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser 
                405                 410                 415     


Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly 
            420                 425                 430         


Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr 
        435                 440                 445             


Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp 
    450                 455                 460                 


Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys 
465                 470                 475                 480 


Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn 
                485                 490                 495     


Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
            500                 505                 510         


Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn Cys Asp Ile Pro Gln 
        515                 520                 525             


Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser Tyr Thr Cys Ser Cys 
    530                 535                 540                 


Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys Gln Asp Val Asp Glu 
545                 550                 555                 560 


Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe Cys Tyr Asn Thr Pro 
                565                 570                 575     


Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr Gln Gly Asp Gly Phe 
            580                 585                 590         


Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg Cys Gln His Glu Arg 
        595                 600                 605             


Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp Pro Gln Arg Pro Ile 
    610                 615                 620                 


Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala His Gly His Tyr Ala 
625                 630                 635                 640 


Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Asp Arg 
                645                 650                 655     


Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg Pro Gly Met Thr Pro 
            660                 665                 670         


Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His Gln Gly Pro Ala Val 
        675                 680                 685             


Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr His Leu Leu Phe Ala 
    690                 695                 700                 


Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu Gly Asn Thr Met Arg 
705                 710                 715                 720 


Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro Ala Lys Val Ile Ile 
                725                 730                 735     


Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val Tyr Trp Thr Asp Ile 
            740                 745                 750         


Thr Glu Pro Ser Ile Gly Arg Ala Ser Leu His Gly Gly Glu Pro Thr 
        755                 760                 765             


Thr Ile Ile Arg Gln Asp Leu Gly Ser Pro Glu Gly Ile Ala Val Asp 
    770                 775                 780                 


His Leu Gly Arg Asn Ile Phe Trp Thr Asp Ser Asn Leu Asp Arg Ile 
785                 790                 795                 800 


Glu Val Ala Lys Leu Asp Gly Thr Gln Arg Arg Val Leu Phe Glu Thr 
                805                 810                 815     


Asp Leu Val Asn Pro Arg Gly Ile Val Thr Asp Ser Val Arg Gly Asn 
            820                 825                 830         


Leu Tyr Trp Thr Asp Trp Asn Arg Asp Asn Pro Lys Ile Glu Thr Ser 
        835                 840                 845             


Tyr Met Asp Gly Thr Asn Arg Arg Ile Leu Val Gln Asp Asp Leu Gly 
    850                 855                 860                 


Leu Pro Asn Gly Leu Thr Phe Asp Ala Phe Ser Ser Gln Leu Cys Trp 
865                 870                 875                 880 


Val Asp Ala Gly Thr Asn Arg Ala Glu Cys Leu Asn Pro Ser Gln Pro 
                885                 890                 895     


Ser Arg Arg Lys Ala Leu Glu Gly Leu Gln Tyr Pro Phe Ala Val Thr 
            900                 905                 910         


Ser Tyr Gly Lys Asn Leu Tyr Phe Thr Asp Trp Lys Met Asn Ser Val 
        915                 920                 925             


Val Ala Leu Asp Leu Ala Ile Ser Lys Glu Thr Asp Ala Phe Gln Pro 
    930                 935                 940                 


His Lys Gln Thr Arg Leu Tyr Gly Ile Thr Thr Ala Leu Ser Gln Cys 
945                 950                 955                 960 


Pro Gln Gly His Asn Tyr Cys Ser Val Asn Asn Gly Gly Cys Thr His 
                965                 970                 975     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Thr Cys Arg Cys Pro Asp Asn 
            980                 985                 990         


Thr Leu Gly Val Asp Cys Ile Glu  Gln Lys 
        995                 1000         


<210>  23
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse miniagrin sequence for AAV

<400>  23

Met Val Arg Pro Arg Leu Ser Phe Pro Ala Pro Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ala Ala Pro Ala Val Pro Gly Ala Ser Gly Thr 
            20                  25                  30          


Cys Pro Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val 
        35                  40                  45              


Leu Thr Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His 
    50                  55                  60                  


Thr Tyr Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp 
65                  70                  75                  80  


Val Val Ala Gln Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile 
                85                  90                  95      


Gly Gly Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly 
            100                 105                 110         


Asp Thr Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro 
        115                 120                 125             


Ala His Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr 
    130                 135                 140                 


Leu Arg Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly 
145                 150                 155                 160 


Ile His Phe Thr Ala Ala Pro Ser Met Pro Pro Asp Val Cys Arg Gly 
                165                 170                 175     


Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro Ser Val Glu Asp Pro 
            180                 185                 190         


Gly Arg Ala Ser Cys Val Cys Lys Lys Asn Val Cys Pro Ala Met Val 
        195                 200                 205             


Ala Pro Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu 
    210                 215                 220                 


Leu Gln Arg Ala Gln Cys Asn Gln Gln Arg Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Gln Gly Pro Cys Pro Pro Lys Ser Cys Asp Ser Gln Pro Cys Leu His 
                245                 250                 255     


Gly Gly Thr Cys Gln Asp Leu Asp Ser Gly Lys Gly Phe Ser Cys Ser 
            260                 265                 270         


Cys Thr Ala Gly Arg Ala Gly Thr Val Cys Glu Lys Val Gln Leu Pro 
        275                 280                 285             


Ser Val Pro Ala Phe Lys Gly His Ser Phe Leu Ala Phe Pro Thr Leu 
    290                 295                 300                 


Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu Glu 
305                 310                 315                 320 


Thr Glu Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp Phe 
                325                 330                 335     


Leu Ala Leu Ala Leu Leu Asp Gly His Val Gln Phe Arg Phe Asp Thr 
            340                 345                 350         


Gly Ser Gly Pro Ala Val Leu Thr Ser Leu Val Pro Val Glu Pro Gly 
        355                 360                 365             


Arg Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Gln Gly Thr Leu 
    370                 375                 380                 


Ser Val Asp Gly Glu Ala Pro Val Val Gly Glu Ser Pro Ser Gly Thr 
385                 390                 395                 400 


Asp Gly Leu Asn Leu Asp Thr Lys Leu Tyr Val Gly Gly Leu Pro Glu 
                405                 410                 415     


Glu Gln Val Ala Thr Val Leu Asp Arg Thr Ser Val Gly Ile Gly Leu 
            420                 425                 430         


Lys Gly Cys Ile Arg Met Leu Asp Ile Asn Asn Gln Gln Leu Glu Leu 
        435                 440                 445             


Ser Asp Trp Gln Arg Ala Val Val Gln Ser Ser Gly Val Gly Glu Cys 
    450                 455                 460                 


Gly Asp His Pro Cys Ser Pro Asn Pro Cys His Gly Gly Ala Leu Cys 
465                 470                 475                 480 


Gln Ala Leu Glu Ala Gly Val Phe Leu Cys Gln Cys Pro Pro Gly Arg 
                485                 490                 495     


Phe Gly Pro Thr Cys Ala Asp Glu Lys Asn Pro Cys Gln Pro Asn Pro 
            500                 505                 510         


Cys His Gly Ser Ala Pro Cys His Val Leu Ser Arg Gly Gly Ala Lys 
        515                 520                 525             


Cys Ala Cys Pro Leu Gly Arg Ser Gly Ser Phe Cys Glu Thr Val Leu 
    530                 535                 540                 


Glu Asn Ala Gly Ser Arg Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser 
545                 550                 555                 560 


Tyr Leu Glu Leu Lys Gly Leu His Thr Phe Glu Arg Asp Leu Gly Glu 
                565                 570                 575     


Lys Met Ala Leu Glu Met Val Phe Leu Ala Arg Gly Pro Ser Gly Leu 
            580                 585                 590         


Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val Ser 
        595                 600                 605             


Leu Ala Leu His Asn Arg His Leu Glu Phe Arg Tyr Asp Leu Gly Lys 
    610                 615                 620                 


Gly Ala Ala Ile Ile Arg Ser Lys Glu Pro Ile Ala Leu Gly Thr Trp 
625                 630                 635                 640 


Val Arg Val Phe Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Gln Val 
                645                 650                 655     


Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro His Thr Met 
            660                 665                 670         


Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser 
        675                 680                 685             


Lys Leu Ala Arg Gly Ala Ala Val Ala Ser Gly Phe Asp Gly Ala Ile 
    690                 695                 700                 


Gln Leu Val Ser Leu Arg Gly His Gln Leu Leu Thr Gln Glu His Val 
705                 710                 715                 720 


Leu Arg Ala Val Asp Val Ala Pro Phe Ala Gly His Pro Cys Thr Gln 
                725                 730                 735     


Ala Val Asp Asn Pro Cys Leu Asn Gly Gly Ser Cys Ile Pro Arg Glu 
            740                 745                 750         


Ala Thr Tyr Glu Cys Leu Cys Pro Gly Gly Phe Ser Gly Leu His Cys 
        755                 760                 765             


Glu Lys Gly Ile Val Glu Lys Ser Val Gly Asp Leu Glu Thr Leu Ala 
    770                 775                 780                 


Phe Asp Gly Arg Thr Tyr Ile Glu Tyr Leu Asn Ala Val Thr Glu Ser 
785                 790                 795                 800 


Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr Glu 
                805                 810                 815     


Ala Thr Gln Gly Leu Val Leu Trp Ile Gly Lys Val Gly Glu Arg Ala 
            820                 825                 830         


Asp Tyr Met Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser Tyr 
        835                 840                 845             


Asp Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Lys Val Asn 
    850                 855                 860                 


Thr Asn Arg Trp Leu Arg Val Arg Ala His Arg Glu His Arg Glu Gly 
865                 870                 875                 880 


Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro Leu 
                885                 890                 895     


Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly Leu 
            900                 905                 910         


Gln Lys Leu Pro Val Gly Gln Ala Leu Pro Lys Ala Tyr Gly Thr Gly 
        915                 920                 925             


Phe Val Gly Cys Leu Arg Asp Val Val Val Gly His Arg Gln Leu His 
    930                 935                 940                 


Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro Thr 
945                 950                 955                 960 


Leu Ile Asp Gly Ser Gly Lys Ala Met 
                965                 


<210>  24
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human shNoG2 nucleotide sequence

<400>  24
atgagggcct ggatcttctt tctcctttgc ctggccggga gggctctggc acggcagaga       60

ggcctgtttc ctgccattct caatcttgcc agcaatgctc acatcagcac caatgccacc      120

tgtggcgaga aggggccgga gatgttctgc aaacttgtgg agcatgtgcc aggtcggccc      180

gtccgaaacc cacagtgccg gatctgtgat ggcaacagcg caaaccccag agaacgccat      240

ccaatatcac atgccataga tggcaccaat aactggtggc aaagtcccag cattcagaat      300

gggagagaat atcactgggt cacaatcact ctggacttaa gacaggtctt tcaagttgca      360

tatgtcatca ttaaagctgc caatgcccct cgacctggaa actggatttt ggagcgttct      420

ctggatggca ccacgttcag cccctggcag tattatgcag tcagcgactc agagtgtttg      480

tctcgttaca atataactcc aagacgaggg ccacccacct acagggctga tgatgaagtg      540

atctgcacct cctattattc cagattggtg ccacttgagc atggagagat tcatacatca      600

ctcatcaatg gcagaccaag cgctgacgat ctttcaccca agttgttgga attcacttct      660

gcacgatata ttcgccttcg cttgcaacgc attagaacgc tcaatgcaga tctcatgacc      720

cttagccacc gggaacctaa agaactggat cctattgtta ccagacgcta ttattattca      780

ataaaggaca tttctgttgg aggcatgtgt atctgctatg gccatgctag tagctgccca      840

tgggatgaaa ctacaaagaa actgcagtgt caatgtgagc ataatacttg cggggagagc      900

tgtaacaggt gctgtcctgg gtaccatcag cagccctgga ggccgggaac cgtgtcctcc      960

ggcaatacat gtgaagcatg taattgtcac aataaagcca aagactgtta ctatgatgaa     1020

agtgttgcaa agcagaagaa aagtttgaat actgctggac agttcagagg aggaggggtt     1080

tgcataaatt gcttgcagaa caccatggga atcaactgtg aaacctgtat tgatggatat     1140

tatagaccac acaaagtgtc tccttatgag gatgagcctt gccgcccctg taattgtgac     1200

cctgtggggt ccctcagttc tgtctgtatt aaggatgacc tccattctga cttacacaat     1260

gggaagcagc caggtcagtg cccatgtaag gaaggttata caggagaaaa atgtgatcgc     1320

tgccaacttg gctataagga ttacccgacc tgtgtctcct gtgggtgcaa cccagtgggc     1380

agtgccagtg atgagccctg cacagggccc tgtgtttgta aggaaaacgt tgaggggaag     1440

gcctgtgatc gctgcaagcc aggattctat aacttgaagg aaaaaaaccc ccggggctgc     1500

tccgagtgct tctgctttgg cgtttctgat gtctgcccca tcaactactg tgaaactggc     1560

cttcataact gcgacatacc ccagcgggcc cagtgtatct acacaggagg ctcctcctac     1620

acctgttcct gcttgccagg cttttctggg gatggccaag cctgccaaga tgtagatgaa     1680

tgccagccaa gccgatgtca ccctgacgcc ttctgctaca acactccagg ctctttcacg     1740

tgccagtgca aacctggtta tcagggagac ggcttccgtt gcgtgcccgg agaggtggag     1800

aaaacccggt gccagcacga gcgagaacac attctcgggg cagcgggggc gacagaccca     1860

cagcgaccca ttcctccggg gctgttcgtt cctgagtgcg atgcgcacgg gcactacgcg     1920

cccacccagt gccacggcag caccggctac tgctggtgcg tggatcgcga cggccgcgag     1980

gtggagggca ccaggaccag gcccgggatg acgcccccgt gtctgagtac agtggctccc     2040

ccgattcacc aaggacctgc ggtgcctacc gccgtgatcc ccttgcctcc tgggacccat     2100

ttactctttg cccagactgg gaagattgag cgcctgcccc tggagggaaa taccatgagg     2160

aagacagaag caaaggcgtt ccttcatgtc ccggctaaag tcatcattgg actggccttt     2220

gactgcgtgg acaagatggt ttactggacg gacatcactg agccttccat tgggagagct     2280

agtctacatg gtggagagcc aaccaccatc attagacaag atcttggaag tccagaaggt     2340

atcgctgttg atcaccttgg ccgcaacatc ttctggacag actctaacct ggatcgaata     2400

gaagtggcga agctggacgg cacgcagcgc cgggtgctct ttgagactga cttggtgaat     2460

cccagaggca ttgtaacgga ttccgtgaga gggaaccttt actggacaga ctggaacaga     2520

gataacccca agattgaaac ttcctacatg gacggcacga accggaggat ccttgtgcag     2580

gatgacctgg gcttgcccaa tggactgacc ttcgatgcgt tctcatctca gctctgctgg     2640

gtggatgcag gcaccaatcg ggcggaatgc ctgaacccca gtcagcccag cagacgcaag     2700

gctctcgaag ggctccagta tccttttgct gtgacgagct acgggaagaa tctgtatttc     2760

acagactgga agatgaattc cgtggttgct ctcgatcttg caatttccaa ggagacggat     2820

gctttccaac cccacaagca gacccggctg tatggcatca ccacggccct gtctcagtgt     2880

ccgcaaggcc ataactactg ctcagtgaac aatggcggct gcacccacct atgcttggcc     2940

accccaggga gcaggacctg ccgttgccct gacaacacct tgggagttga ctgtatcgaa     3000

cagaaatga                                                             3009


<210>  25
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse BM-40 (Sparc) signal sequence [DNA, 51 bp)

<400>  25
atgagggcct ggatcttctt tctcctttgc ctggccggga gggctctggc a                51


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse BM-40 (Sparc) signal peptide

<400>  26

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  27
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 endogenous signal sequence [DNA, 72 bp]

<400>  27
atgcgcggca gcggcacggg agccgcgctc ctggtgctcc tggcctcggt gctctgggtc       60

accgtgcgga gc                                                           72


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse laminin alpha 1 endogenous signal peptide

<400>  28

Met Arg Gly Ser Gly Thr Gly Ala Ala Leu Leu Val Leu Leu Ala Ser 
1               5                   10                  15      


Val Leu Trp Val Thr Val Arg Ser 
            20                  


<210>  29
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laminin (Lm) alpha 1 signal peptide [DNA, 51 bp]

<400>  29
atgagggcct ggatcttctt tctcctttgc ctggccggga gggctctggc a                51


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human laminin alpha 1 signal peptide

<400>  30

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LN domain [DNA, 753 bp]

<400>  31
cagcagagag gcttgttccc tgccattctc aacctggcca ccaatgccca catcagcgcc       60

aatgctacct gtggagagaa ggggcctgag atgttctgca aactcgtgga gcacgtgccg      120

ggccggcctg ttcgacacgc ccaatgccgg gtctgtgacg gtaacagtac gaatcctaga      180

gagcgccatc cgatatcaca cgcaatcgat ggcaccaaca actggtggca gagccccagt      240

attcagaatg ggagagagta tcactgggtc actgtcaccc tggacttacg gcaggtcttt      300

caagttgcat acatcatcat taaagctgcc aatgcccctc ggcctggaaa ctggattttg      360

gagcgctccg tggatggcgt caagttcaaa ccctggcagt actatgccgt cagcgataca      420

gagtgtttga cccgctacaa aataactcca cggcggggac ctcccactta cagagcagac      480

aacgaagtca tctgcacctc gtattattca aagctggtgc cacttgaaca tggagagatt      540

cacacatcac tcatcaatgg cagacccagc gctgacgacc cctcacccca gttgctggaa      600

ttcacctcag cacggtacat tcgccttcgt cttcagcgca tcagaacact caacgcagac      660

ctcatgaccc ttagccatcg ggacctcaga gaccttgacc ccattgtcac aagacgttat      720

tactattcga taaaagacat ttccgttgga ggc                                   753


<210>  32
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LN  [polymerization domain]

<400>  32

Gln Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Thr Asn Ala 
1               5                   10                  15      


His Ile Ser Ala Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met Phe 
            20                  25                  30          


Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg His Ala Gln 
        35                  40                  45              


Cys Arg Val Cys Asp Gly Asn Ser Thr Asn Pro Arg Glu Arg His Pro 
    50                  55                  60                  


Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro Ser 
65                  70                  75                  80  


Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Val Thr Leu Asp Leu 
                85                  90                  95      


Arg Gln Val Phe Gln Val Ala Tyr Ile Ile Ile Lys Ala Ala Asn Ala 
            100                 105                 110         


Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Val Asp Gly Val Lys 
        115                 120                 125             


Phe Lys Pro Trp Gln Tyr Tyr Ala Val Ser Asp Thr Glu Cys Leu Thr 
    130                 135                 140                 


Arg Tyr Lys Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala Asp 
145                 150                 155                 160 


Asn Glu Val Ile Cys Thr Ser Tyr Tyr Ser Lys Leu Val Pro Leu Glu 
                165                 170                 175     


His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala Asp 
            180                 185                 190         


Asp Pro Ser Pro Gln Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile Arg 
        195                 200                 205             


Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr Leu 
    210                 215                 220                 


Ser His Arg Asp Leu Arg Asp Leu Asp Pro Ile Val Thr Arg Arg Tyr 
225                 230                 235                 240 


Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly 
                245                 250     


<210>  33
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LN [DNA, 753 bp]

<400>  33
cggcagagag gcctgtttcc tgccattctc aatcttgcca gcaatgctca catcagcacc       60

aatgccacct gtggcgagaa ggggccggag atgttctgca aacttgtgga gcatgtgcca      120

ggtcggcccg tccgaaaccc acagtgccgg atctgtgatg gcaacagcgc aaaccccaga      180

gaacgccatc caatatcaca tgccatagat ggcaccaata actggtggca aagtcccagc      240

attcagaatg ggagagaata tcactggcgg cagagaggcc tgtttcctgc cattctcaat      300

cttgccagca atgctcacat cagcaccaat gccacctgtg gcgagaaggg gccggagatg      360

ttctgcaaac ttgtggagca tgtgccaggt cggcccgtcc gaaacccaca gtgccggatc      420

tgtgatggca acagcgcaaa ccccagagaa cgccatccaa tatcacatgc catagatggc      480

accaataact ggtggcaaag tcccagcatt cagaatggga gagaatatca ctgggtcaca      540

atcactctgg acttaagaca ggtctttcaa gttgcatatg tcatcattaa agctgccaat      600

gcccctcgac ctggaaactg gattttggag cgttctctgg atggcaccac gttcagcccc      660

tggcagtatt atgcagtcag cgactcagag tgtttgtctc gttacaatat aactccaaga      720

cgagggccac ccacctacag ggctgatgat gaagtgatct gcacctccta ttattccaga      780

ttggtgccac ttgagcatgg agagattcat acatcactca tcaatggcag accaagcgct      840

gacgatcttt cacccaagtt gttggaattc acttctgcac gatatattcg ccttcgcttg      900

caacgcatta gaacgctcaa tgcagatctc atgaccctta gccaccggga acctaaagaa      960

ctggatccta ttgttaccag acgctattat tattcaataa aggacatttc tgttggaggc     1020


<210>  34
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LN

<400>  34

Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn Ala 
1               5                   10                  15      


His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met Phe 
            20                  25                  30          


Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro Gln 
        35                  40                  45              


Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His Pro 
    50                  55                  60                  


Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro Ser 
65                  70                  75                  80  


Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp Leu 
                85                  90                  95      


Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn Ala 
            100                 105                 110         


Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr Thr 
        115                 120                 125             


Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu Ser 
    130                 135                 140                 


Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala Asp 
145                 150                 155                 160 


Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu Glu 
                165                 170                 175     


His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala Asp 
            180                 185                 190         


Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile Arg 
        195                 200                 205             


Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr Leu 
    210                 215                 220                 


Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg Tyr 
225                 230                 235                 240 


Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly 
                245                 250     


<210>  35
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-1 domain [DNA, 171 bp]

<400>  35
atgtgcattt gctacggcca tgccagcagc tgcccgtggg atgaagaagc aaagcaacta       60

cagtgtcagt gtgaacacaa tacgtgtggc gagagctgcg acaggtgctg tcctggctac      120

catcagcagc cctggaggcc cggaaccatt tcctccggca acgagtgtga g               171


<210>  36
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-1 [required for LN folding; spacer domain]

<400>  36

Met Cys Ile Cys Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Glu 
1               5                   10                  15      


Ala Lys Gln Leu Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser 
            20                  25                  30          


Cys Asp Arg Cys Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly 
        35                  40                  45              


Thr Ile Ser Ser Gly Asn Glu Cys Glu 
    50                  55          


<210>  37
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-1 [DNA, 171 bp]

<400>  37
atgtgtatct gctatggcca tgctagtagc tgcccatggg atgaaactac aaagaaactg       60

cagtgtcaat gtgagcataa tacttgcggg gagagctgta acaggtgctg tcctgggtac      120

catcagcagc cctggaggcc gggaaccgtg tcctccggca atacatgtga a               171


<210>  38
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-1

<400>  38

Met Cys Ile Cys Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr 
1               5                   10                  15      


Thr Lys Lys Leu Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser 
            20                  25                  30          


Cys Asn Arg Cys Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly 
        35                  40                  45              


Thr Val Ser Ser Gly Asn Thr Cys Glu 
    50                  55          


<210>  39
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-2 domain [DNA, 210 bp]

<400>  39
gaatgcaact gtcacaacaa agccaaagat tgttactatg acagcagtgt tgcaaaggag       60

aggagaagcc tgaacactgc cgggcagtac agtggaggag gggtttgtgt caactgctcg      120

cagaatacca cagggatcaa ctgtgaaacc tgtatcgacc agtattacag acctcacaag      180

gtatctcctt atgatgacca cccttgccgt                                       210


<210>  40
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-2 [required for LN folding; spacer domain]

<400>  40

Glu Cys Asn Cys His Asn Lys Ala Lys Asp Cys Tyr Tyr Asp Ser Ser 
1               5                   10                  15      


Val Ala Lys Glu Arg Arg Ser Leu Asn Thr Ala Gly Gln Tyr Ser Gly 
            20                  25                  30          


Gly Gly Val Cys Val Asn Cys Ser Gln Asn Thr Thr Gly Ile Asn Cys 
        35                  40                  45              


Glu Thr Cys Ile Asp Gln Tyr Tyr Arg Pro His Lys Val Ser Pro Tyr 
    50                  55                  60                  


Asp Asp His Pro Cys Arg 
65                  70  


<210>  41
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-2 [DNA, 210 bp]

<400>  41
gcatgtaatt gtcacaataa agccaaagac tgttactatg atgaaagtgt tgcaaagcag       60

aagaaaagtt tgaatactgc tggacagttc agaggaggag gggtttgcat aaattgcttg      120

cagaacacca tgggaatcaa ctgtgaaacc tgtattgatg gatattatag accacacaaa      180

gtgtctcctt atgaggatga gccttgccgc                                       210


<210>  42
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-2

<400>  42

Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys Tyr Tyr Asp Glu Ser 
1               5                   10                  15      


Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala Gly Gln Phe Arg Gly 
            20                  25                  30          


Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr Met Gly Ile Asn Cys 
        35                  40                  45              


Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His Lys Val Ser Pro Tyr 
    50                  55                  60                  


Glu Asp Glu Pro Cys Arg 
65                  70  


<210>  43
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-3 domain [DNA, 171 bp]

<400>  43
ccctgtaact gtgaccctgt ggggtctctg agttctgtct gtatcaagga tgaccgccat       60

gccgatttag ccaatggaaa gtggccaggt cagtgtccat gtaggaaagg ttatgctgga      120

gataaatgtg accgctgcca gtttggctac cggggtttcc caaattgcat c               171


<210>  44
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-3 [domain acting as spacer]

<400>  44

Pro Cys Asn Cys Asp Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys 
1               5                   10                  15      


Asp Asp Arg His Ala Asp Leu Ala Asn Gly Lys Trp Pro Gly Gln Cys 
            20                  25                  30          


Pro Cys Arg Lys Gly Tyr Ala Gly Asp Lys Cys Asp Arg Cys Gln Phe 
        35                  40                  45              


Gly Tyr Arg Gly Phe Pro Asn Cys Ile 
    50                  55          


<210>  45
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-3 [DNA, 171 bp]

<400>  45
ccctgtaatt gtgaccctgt ggggtccctc agttctgtct gtattaagga tgacctccat       60

tctgacttac acaatgggaa gcagccaggt cagtgcccat gtaaggaagg ttatacagga      120

gaaaaatgtg atcgctgcca acttggctat aaggattacc cgacctgtgt c               171


<210>  46
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-3

<400>  46

Pro Cys Asn Cys Asp Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys 
1               5                   10                  15      


Asp Asp Leu His Ser Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys 
            20                  25                  30          


Pro Cys Lys Glu Gly Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu 
        35                  40                  45              


Gly Tyr Lys Asp Tyr Pro Thr Cys Val 
    50                  55          


<210>  47
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-4 domain [DNA, 147 bp]

<400>  47
ccctgtgact gcaggactgt cggcagcctg aatgaggatc catgcataga gccgtgtctt       60

tgtaagaaaa atgttgaggg taagaactgt gatcgctgca agccaggatt ctacaacttg      120

aaggaacgaa accccgaggg ctgctcc                                          147


<210>  48
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LEa-4 [spacer domain]

<400>  48

Pro Cys Asp Cys Arg Thr Val Gly Ser Leu Asn Glu Asp Pro Cys Ile 
1               5                   10                  15      


Glu Pro Cys Leu Cys Lys Lys Asn Val Glu Gly Lys Asn Cys Asp Arg 
            20                  25                  30          


Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Arg Asn Pro Glu Gly Cys 
        35                  40                  45              


Ser 
    


<210>  49
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-4 [DNA, 147 bp]

<400>  49
tcctgtgggt gcaacccagt gggcagtgcc agtgatgagc cctgcacagg gccctgtgtt       60

tgtaaggaaa acgttgaggg gaaggcctgt gatcgctgca agccaggatt ctataacttg      120

aaggaaaaaa acccccgggg ctgctcc                                          147


<210>  50
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LEa-4

<400>  50

Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp Glu Pro Cys Thr 
1               5                   10                  15      


Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys Ala Cys Asp Arg 
            20                  25                  30          


Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn Pro Arg Gly Cys 
        35                  40                  45              


Ser 
    


<210>  51
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LF domain LE-type fragment with 3 cys [DNA, 33 bp]

<400>  51
gagtgcttct gcttcggtgt ctctggtgtc tgt                                    33


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lm alpha 1 LF fragment (with 3 cys) [spacer segment]

<400>  52

Glu Cys Phe Cys Phe Gly Val Ser Gly Val Cys 
1               5                   10      


<210>  53
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LF fragment (with 3 cys)[DNA, 33 bp]

<400>  53
gagtgcttct gctttggcgt ttctgatgtc tgc                                    33


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lm alpha 1 LF fragment (with 3 cys)

<400>  54

Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
1               5                   10  


<210>  55
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 G2 domain [DNA, 843 bp]

<400>  55
cagcagactt gtgccaacaa tagacaccag tgctccgtgc atgcagagtg cagagactat       60

gctactggct tctgctgcag gtgtgtggcc aactacacag gcaatggcag acagtgcgtg      120

gcagaaggct ctccacaacg ggtcaatggc aaggtgaagg gaaggatctt cgtggggagc      180

agccaggtcc ccgtggtgtt tgagaacact gacctgcact cctatgtggt gatgaaccac      240

gggcgctctt acacagccat cagcaccatc cctgaaaccg tcggctactc tctgctcccc      300

ctggcaccca ttggaggcat catcggatgg atgtttgcag tggagcagga tgggttcaag      360

aatgggttta gcatcactgg gggcgagttt acccggcaag ctgaggtgac cttcctgggg      420

cacccaggca agctggtcct gaagcagcag ttcagcggta ttgatgaaca tggacacctg      480

accatcagca cggagctgga gggccgcgtg ccgcagatcc cctatggagc ctcggtgcac      540

attgagccct acaccgaact gtaccactac tccagctcag tgatcacttc ctcctccacc      600

cgggagtaca cggtgatgga gcctgatcag gacggcgctg caccctcaca cacccatatt      660

taccagtggc gtcagaccat caccttccag gagtgtgccc acgatgacgc caggccagcc      720

ctgcccagca cccagcagct ctctgtggac agcgtgtttg tcctgtacaa caaggaggag      780

aggatcttgc gctatgccct cagcaactcc atcgggcctg tgagggatgg ctcccctgat      840

gcc                                                                    843


<210>  56
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 G2 domain [direct collagen-IV, perlecan binding]

<400>  56

Gln Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His Ala Glu 
1               5                   10                  15      


Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Arg Cys Val Ala Asn Tyr 
            20                  25                  30          


Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln Arg Val 
        35                  40                  45              


Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln Val Pro 
    50                  55                  60                  


Val Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met Asn His 
65                  70                  75                  80  


Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val Gly Tyr 
                85                  90                  95      


Ser Leu Leu Pro Leu Ala Pro Ile Gly Gly Ile Ile Gly Trp Met Phe 
            100                 105                 110         


Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr Gly Gly 
        115                 120                 125             


Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Leu Gly His Pro Gly Lys 
    130                 135                 140                 


Leu Val Leu Lys Gln Gln Phe Ser Gly Ile Asp Glu His Gly His Leu 
145                 150                 155                 160 


Thr Ile Ser Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro Tyr Gly 
                165                 170                 175     


Ala Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr Ser Ser 
            180                 185                 190         


Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Met Glu Pro 
        195                 200                 205             


Asp Gln Asp Gly Ala Ala Pro Ser His Thr His Ile Tyr Gln Trp Arg 
    210                 215                 220                 


Gln Thr Ile Thr Phe Gln Glu Cys Ala His Asp Asp Ala Arg Pro Ala 
225                 230                 235                 240 


Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val Leu Tyr 
                245                 250                 255     


Asn Lys Glu Glu Arg Ile Leu Arg Tyr Ala Leu Ser Asn Ser Ile Gly 
            260                 265                 270         


Pro Val Arg Asp Gly Ser Pro Asp Ala 
        275                 280     


<210>  57
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G2 domain (direct collagen-IV, perlecan 
       binding)[DNA, 843 bp]

<400>  57
cgccagacgt gtgctaacaa cagacaccag tgctcggtgc acgcagagtg cagggactac       60

gccacgggct tctgctgcag ctgtgtcgct ggctatacgg gcaatggcag gcaatgtgtt      120

gcagaaggtt ccccccagcg agtcaatggc aaggtgaaag gaaggatctt tgtggggagc      180

agccaggtcc ccattgtctt tgagaacact gacctccact cttacgtagt aatgaaccac      240

gggcgctcct acacagccat cagcaccatt cccgagaccg ttggatattc tctgcttcca      300

ctggccccag ttggaggcat cattggatgg atgtttgcag tggagcagga cggattcaag      360

aatgggttca gcatcaccgg gggtgagttc actcgccagg ctgaggtgac cttcgtgggg      420

cacccgggca atctggtcat taagcagcgg ttcagcggca tcgatgagca tgggcacctg      480

accatcgaca cggagctgga gggccgcgtg ccgcagattc cgttcggctc ctccgtgcac      540

attgagccct acacggagct gtaccactac tccacctcag tgatcacttc ctcctccacc      600

cgggagtaca cggtgactga gcccgagcga gatggggcat ctccttcacg catctacact      660

taccagtggc gccagaccat caccttccag gaatgcgtcc acgatgactc ccggccagcc      720

ctgcccagca cccagcagct ctcggtggac agcgtgttcg tcctgtacaa ccaggaggag      780

aagatcttgc gctatgctct cagcaactcc attgggcctg tgagggaagg ctcccctgat      840

gct                                                                    843


<210>  58
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G2 domain (direct collagen-IV, perlecan binding)

<400>  58

Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His Ala Glu 
1               5                   10                  15      


Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala Gly Tyr 
            20                  25                  30          


Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln Arg Val 
        35                  40                  45              


Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln Val Pro 
    50                  55                  60                  


Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met Asn His 
65                  70                  75                  80  


Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val Gly Tyr 
                85                  90                  95      


Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp Met Phe 
            100                 105                 110         


Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr Gly Gly 
        115                 120                 125             


Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro Gly Asn 
    130                 135                 140                 


Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly His Leu 
145                 150                 155                 160 


Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro Phe Gly 
                165                 170                 175     


Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr Ser Thr 
            180                 185                 190         


Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr Glu Pro 
        195                 200                 205             


Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln Trp Arg 
    210                 215                 220                 


Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg Pro Ala 
225                 230                 235                 240 


Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val Leu Tyr 
                245                 250                 255     


Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser Ile Gly 
            260                 265                 270         


Pro Val Arg Glu Gly Ser Pro Asp Ala 
        275                 280     


<210>  59
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 2 domain [126 bp]

<400>  59
cttcagaatc catgctacat tggcacccat gggtgtgaca gcaatgctgc ctgtcgccct       60

ggccctggaa cacagttcac ctgcgaatgc tccatcggct tccgaggaga cgggcagact      120

tgctat                                                                 126


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 2 [spacer]

<400>  60

Leu Gln Asn Pro Cys Tyr Ile Gly Thr His Gly Cys Asp Ser Asn Ala 
1               5                   10                  15      


Ala Cys Arg Pro Gly Pro Gly Thr Gln Phe Thr Cys Glu Cys Ser Ile 
            20                  25                  30          


Gly Phe Arg Gly Asp Gly Gln Thr Cys Tyr 
        35                  40          


<210>  61
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 2 domain [DNA, 126 bp]

<400>  61
cttcagaatc cctgctacat cggcactcat gggtgtgaca ccaacgcggc ctgtcgccct       60

ggtcccagga cacagttcac ctgcgagtgc tccatcggct tccgaggaga cgggcgaacc      120

tgctat                                                                 126


<210>  62
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 2 domain

<400>  62

Leu Gln Asn Pro Cys Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala 
1               5                   10                  15      


Ala Cys Arg Pro Gly Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile 
            20                  25                  30          


Gly Phe Arg Gly Asp Gly Arg Thr Cys Tyr 
        35                  40          


<210>  63
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Niogen-1 EGF-like 3 domain [126 bp]:

<400>  63
gatattgatg agtgttcaga gcagccttcc cgctgtggga accatgcggt ctgcaacaac       60

ctcccaggaa ccttccgctg cgagtgtgta gagggctacc acttctcaga caggggaaca      120

tgcgtg                                                                 126


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 3

<400>  64

Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Arg Cys Gly Asn His Ala 
1               5                   10                  15      


Val Cys Asn Asn Leu Pro Gly Thr Phe Arg Cys Glu Cys Val Glu Gly 
            20                  25                  30          


Tyr His Phe Ser Asp Arg Gly Thr Cys Val 
        35                  40          


<210>  65
<211>  126
<212>  DNA
<213>  Artficial Sequence

<400>  65
cttcagaatc cctgctacat cggcactcat gggtgtgaca ccaacgcggc ctgtcgccct       60

ggtcccagga cacagttcac ctgcgagtgc tccatcggct tccgaggaga cgggcgaacc      120

tgctat                                                                 126


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 3 domain

<400>  66

Leu Gln Asn Pro Cys Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala 
1               5                   10                  15      


Ala Cys Arg Pro Gly Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile 
            20                  25                  30          


Gly Phe Arg Gly Asp Gly Arg Thr Cys Tyr 
        35                  40          


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 spacer segment between EGF-3 and -4 [DNA, 18 bp]

<400>  67
gctgccgagg accaacgt                                                     18


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 spacer segment between EGF-3 and -4

<400>  68

Ala Ala Glu Asp Gln Arg 
1               5       


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 spacer segment between EGF-3 and -4 [DNA, 18 bp]

<400>  69
gctgtcgtgg accagcgc                                                     18


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 spacer segment between EGF-3 and -4

<400>  70

Ala Val Val Asp Gln Arg 
1               5       


<210>  71
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 4 domain [132 bp]

<400>  71
cccatcaact actgtgaaac tggtctccac aactgtgata tcccccagcg agcccagtgc       60

atctatatgg gtggttcctc ctacacctgc tcctgtctgc ctggcttctc tggggatggc      120

agagcctgcc ga                                                          132


<210>  72
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 4

<400>  72

Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn Cys Asp Ile Pro Gln 
1               5                   10                  15      


Arg Ala Gln Cys Ile Tyr Met Gly Gly Ser Ser Tyr Thr Cys Ser Cys 
            20                  25                  30          


Leu Pro Gly Phe Ser Gly Asp Gly Arg Ala Cys Arg 
        35                  40                  


<210>  73
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 4 domain [DNA, 132 bp]

<400>  73
cccatcaact actgtgaaac tggccttcat aactgcgaca taccccagcg ggcccagtgt       60

atctacacag gaggctcctc ctacacctgt tcctgcttgc caggcttttc tggggatggc      120

caagcctgcc aa                                                          132


<210>  74
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 4 domain

<400>  74

Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn Cys Asp Ile Pro Gln 
1               5                   10                  15      


Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser Tyr Thr Cys Ser Cys 
            20                  25                  30          


Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys Gln 
        35                  40                  


<210>  75
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 5 domain [DNA, 141 bp]

<400>  75
gacgtggatg aatgccagca cagccgatgt caccccgatg ccttctgcta caacacacca       60

ggctctttca catgtcagtg caagcctggc tatcaggggg atggcttccg atgcatgccc      120

ggagaggtga gcaaaacccg g                                                141


<210>  76
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 EGF-like 5 [spacer]

<400>  76

Asp Val Asp Glu Cys Gln His Ser Arg Cys His Pro Asp Ala Phe Cys 
1               5                   10                  15      


Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr Gln 
            20                  25                  30          


Gly Asp Gly Phe Arg Cys Met Pro Gly Glu Val Ser Lys Thr Arg 
        35                  40                  45          


<210>  77
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 5 domain [DNA, 141 bp]

<400>  77
gatgtagatg aatgccagcc aagccgatgt caccctgacg ccttctgcta caacactcca       60

ggctctttca cgtgccagtg caaacctggt tatcagggag acggcttccg ttgcgtgccc      120

ggagaggtgg agaaaacccg g                                                141


<210>  78
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 EGF-like 5 domain

<400>  78

Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe Cys 
1               5                   10                  15      


Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr Gln 
            20                  25                  30          


Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        35                  40                  45          


<210>  79
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 G3 TY (thyroglobulin-like) domain [DNA, 282 bp]

<400>  79
tgtcaactgg aacgagagca catccttgga gcagccggcg gggcagatgc acagcggccc       60

accctgcagg ggatgtttgt gcctcagtgt gatgaatatg gacactatgt acccacccag      120

tgtcaccaca gcactggcta ctgctggtgt gtggaccgag atggtcggga gctggagggt      180

agccgtaccc cacctgggat gaggcccccg tgtctgagta cagtggctcc tcctattcac      240

cagggaccag tagtacctac agctgtcatc cccctgcctc ca                         282


<210>  80
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen "G3" TY (thyroglobulin-like) domain

<400>  80

Cys Gln Leu Glu Arg Glu His Ile Leu Gly Ala Ala Gly Gly Ala Asp 
1               5                   10                  15      


Ala Gln Arg Pro Thr Leu Gln Gly Met Phe Val Pro Gln Cys Asp Glu 
            20                  25                  30          


Tyr Gly His Tyr Val Pro Thr Gln Cys His His Ser Thr Gly Tyr Cys 
        35                  40                  45              


Trp Cys Val Asp Arg Asp Gly Arg Glu Leu Glu Gly Ser Arg Thr Pro 
    50                  55                  60                  


Pro Gly Met Arg Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
65                  70                  75                  80  


Gln Gly Pro Val Val Pro Thr Ala Val Ile Pro Leu Pro Pro 
                85                  90                  


<210>  81
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 TY (thyroglobulin-like) domain [DNA, 282 bp]

<400>  81
tgccagcacg agcgagaaca cattctcggg gcagcggggg cgacagaccc acagcgaccc       60

attcctccgg ggctgttcgt tcctgagtgc gatgcgcacg ggcactacgc gcccacccag      120

tgccacggca gcaccggcta ctgctggtgc gtggatcgcg acggccgcga ggtggagggc      180

accaggacca ggcccgggat gacgcccccg tgtctgagta cagtggctcc cccgattcac      240

caaggacctg cggtgcctac cgccgtgatc cccttgcctc ct                         282


<210>  82
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 TY (thyroglobulin-like) domain

<400>  82

Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
1               5                   10                  15      


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
            20                  25                  30          


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
        35                  40                  45              


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
    50                  55                  60                  


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
65                  70                  75                  80  


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro 
                85                  90                  


<210>  83
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 G3 beta-Propeller domain [DNA, 744 bp]

<400>  83
gggacacact tactctttgc tcagactgga aagattgaac gcctgcccct ggaaagaaac       60

accatgaaga agacagaacg caaggccttt ctccatatcc ctgcaaaagt catcattgga      120

ctggcctttg actgcgtgga caaggtggtt tactggacag acatcagcga gccttccatt      180

gggagagcca gcctccacgg tggagagcca accaccatca ttcgacaaga tcttggaagc      240

cctgaaggca ttgcccttga ccatcttggt cgaaccatct tctggacgga ctctcagttg      300

gatcgaatag aagttgcaaa gatggatggc acccagcgcc gagtgctgtt tgacacgggt      360

ttggtgaatc ccagaggcat tgtgacagac cccgtaagag ggaaccttta ttggacagat      420

tggaacagag ataatcccaa aattgagact tctcacatgg atggcaccaa ccggaggatt      480

ctcgcacagg acaacctggg cttgcccaat ggtctgacct ttgatgcatt ctcatctcag      540

ctttgctggg tggatgcagg cacccatagg gcagaatgcc tgaacccagc tcagcctggc      600

agacgcaaag ttctcgaagg gctccagtat cctttcgctg tgactagcta tgggaagaat      660

ttgtactaca cagactggaa gacgaattca gtgattgcca tggaccttgc tatatccaaa      720

gagatggata ccttccaccc acac                                             744


<210>  84
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen "G3" beta-Propeller [laminin-binding domain]

<400>  84

Gly Thr His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro 
1               5                   10                  15      


Leu Glu Arg Asn Thr Met Lys Lys Thr Glu Arg Lys Ala Phe Leu His 
            20                  25                  30          


Ile Pro Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys 
        35                  40                  45              


Val Val Tyr Trp Thr Asp Ile Ser Glu Pro Ser Ile Gly Arg Ala Ser 
    50                  55                  60                  


Leu His Gly Gly Glu Pro Thr Thr Ile Ile Arg Gln Asp Leu Gly Ser 
65                  70                  75                  80  


Pro Glu Gly Ile Ala Leu Asp His Leu Gly Arg Thr Ile Phe Trp Thr 
                85                  90                  95      


Asp Ser Gln Leu Asp Arg Ile Glu Val Ala Lys Met Asp Gly Thr Gln 
            100                 105                 110         


Arg Arg Val Leu Phe Asp Thr Gly Leu Val Asn Pro Arg Gly Ile Val 
        115                 120                 125             


Thr Asp Pro Val Arg Gly Asn Leu Tyr Trp Thr Asp Trp Asn Arg Asp 
    130                 135                 140                 


Asn Pro Lys Ile Glu Thr Ser His Met Asp Gly Thr Asn Arg Arg Ile 
145                 150                 155                 160 


Leu Ala Gln Asp Asn Leu Gly Leu Pro Asn Gly Leu Thr Phe Asp Ala 
                165                 170                 175     


Phe Ser Ser Gln Leu Cys Trp Val Asp Ala Gly Thr His Arg Ala Glu 
            180                 185                 190         


Cys Leu Asn Pro Ala Gln Pro Gly Arg Arg Lys Val Leu Glu Gly Leu 
        195                 200                 205             


Gln Tyr Pro Phe Ala Val Thr Ser Tyr Gly Lys Asn Leu Tyr Tyr Thr 
    210                 215                 220                 


Asp Trp Lys Thr Asn Ser Val Ile Ala Met Asp Leu Ala Ile Ser Lys 
225                 230                 235                 240 


Glu Met Asp Thr Phe His Pro His 
                245             


<210>  85
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 beta-Propeller domain [DNA, 744 bp]

<400>  85
gggacccatt tactctttgc ccagactggg aagattgagc gcctgcccct ggagggaaat       60

accatgagga agacagaagc aaaggcgttc cttcatgtcc cggctaaagt catcattgga      120

ctggcctttg actgcgtgga caagatggtt tactggacgg acatcactga gccttccatt      180

gggagagcta gtctacatgg tggagagcca accaccatca ttagacaaga tcttggaagt      240

ccagaaggta tcgctgttga tcaccttggc cgcaacatct tctggacaga ctctaacctg      300

gatcgaatag aagtggcgaa gctggacggc acgcagcgcc gggtgctctt tgagactgac      360

ttggtgaatc ccagaggcat tgtaacggat tccgtgagag ggaaccttta ctggacagac      420

tggaacagag ataaccccaa gattgaaact tcctacatgg acggcacgaa ccggaggatc      480

cttgtgcagg atgacctggg cttgcccaat ggactgacct tcgatgcgtt ctcatctcag      540

ctctgctggg tggatgcagg caccaatcgg gcggaatgcc tgaaccccag tcagcccagc      600

agacgcaagg ctctcgaagg gctccagtat ccttttgctg tgacgagcta cgggaagaat      660

ctgtatttca cagactggaa gatgaattcc gtggttgctc tcgatcttgc aatttccaag      720

gagacggatg ctttccaacc ccac                                             744


<210>  86
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 beta-Propeller domain

<400>  86

Gly Thr His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro 
1               5                   10                  15      


Leu Glu Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His 
            20                  25                  30          


Val Pro Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys 
        35                  40                  45              


Met Val Tyr Trp Thr Asp Ile Thr Glu Pro Ser Ile Gly Arg Ala Ser 
    50                  55                  60                  


Leu His Gly Gly Glu Pro Thr Thr Ile Ile Arg Gln Asp Leu Gly Ser 
65                  70                  75                  80  


Pro Glu Gly Ile Ala Val Asp His Leu Gly Arg Asn Ile Phe Trp Thr 
                85                  90                  95      


Asp Ser Asn Leu Asp Arg Ile Glu Val Ala Lys Leu Asp Gly Thr Gln 
            100                 105                 110         


Arg Arg Val Leu Phe Glu Thr Asp Leu Val Asn Pro Arg Gly Ile Val 
        115                 120                 125             


Thr Asp Ser Val Arg Gly Asn Leu Tyr Trp Thr Asp Trp Asn Arg Asp 
    130                 135                 140                 


Asn Pro Lys Ile Glu Thr Ser Tyr Met Asp Gly Thr Asn Arg Arg Ile 
145                 150                 155                 160 


Leu Val Gln Asp Asp Leu Gly Leu Pro Asn Gly Leu Thr Phe Asp Ala 
                165                 170                 175     


Phe Ser Ser Gln Leu Cys Trp Val Asp Ala Gly Thr Asn Arg Ala Glu 
            180                 185                 190         


Cys Leu Asn Pro Ser Gln Pro Ser Arg Arg Lys Ala Leu Glu Gly Leu 
        195                 200                 205             


Gln Tyr Pro Phe Ala Val Thr Ser Tyr Gly Lys Asn Leu Tyr Phe Thr 
    210                 215                 220                 


Asp Trp Lys Met Asn Ser Val Val Ala Leu Asp Leu Ala Ile Ser Lys 
225                 230                 235                 240 


Glu Thr Asp Ala Phe Gln Pro His 
                245             


<210>  87
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen-1 G3 EGF-like 6 domain [DNA, 171 bp]

<400>  87
aagcagaccc ggctatatgg catcaccatc gccctgtccc agtgtcccca aggccacaat       60

tactgctcag tgaataatgg tggatgtacc cacctctgct tgcccactcc agggagcagg      120

acctgccgat gtcctgacaa caccctggga gttgactgca ttgaacggaa a               171


<210>  88
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Nidogen "G3" EGF-like 6 [contacts laminin LE surface]

<400>  88

Lys Gln Thr Arg Leu Tyr Gly Ile Thr Ile Ala Leu Ser Gln Cys Pro 
1               5                   10                  15      


Gln Gly His Asn Tyr Cys Ser Val Asn Asn Gly Gly Cys Thr His Leu 
            20                  25                  30          


Cys Leu Pro Thr Pro Gly Ser Arg Thr Cys Arg Cys Pro Asp Asn Thr 
        35                  40                  45              


Leu Gly Val Asp Cys Ile Glu Arg Lys 
    50                  55          


<210>  89
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 EGF-like 6 domain [DNA, 162 bp]

<400>  89
aagcagaccc ggctgtatgg catcaccacg gccctgtctc agtgtccgca aggccataac       60

tactgctcag tgaacaatgg cggctgcacc cacctatgct tggccacccc agggagcagg      120

acctgccgtt gccctgacaa caccttggga gttgactgta tc                         162


<210>  90
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Nidogen-1 G3 EGF-like 6 domain

<400>  90

Lys Gln Thr Arg Leu Tyr Gly Ile Thr Thr Ala Leu Ser Gln Cys Pro 
1               5                   10                  15      


Gln Gly His Asn Tyr Cys Ser Val Asn Asn Gly Gly Cys Thr His Leu 
            20                  25                  30          


Cys Leu Ala Thr Pro Gly Ser Arg Thr Cys Arg Cys Pro Asp Asn Thr 
        35                  40                  45              


Leu Gly Val Asp Cys Ile 
    50                  


<210>  91
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 signal peptide [63 bp]:

<400>  91
atggggctgc tccaggtgtt cgcctttggt gtcctagccc tatggggcac ccgagtgtgc       60

gct                                                                     63


<210>  92
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 signal peptide

<400>  92

Met Gly Leu Leu Gln Val Phe Ala Phe Gly Val Leu Ala Leu Trp Gly 
1               5                   10                  15      


Thr Arg Val Cys Ala 
            20      


<210>  93
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 signal [63 bp]

<400>  93
atggggcttc tccagttgct agctttcagt ttcttagccc tgtgcagagc ccgagtgcgc       60

gct                                                                     63


<210>  94
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 signal peptide

<400>  94

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala 
            20      


<210>  95
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LN domain [744 bp]

<400>  95
caggaaccgg agttcagcta tggctgcgca gaaggcagct gctaccctgc cactggcgac       60

cttctcatcg gccgagcgca aaagctctcc gtgacttcga catgtggact gcacaaacca      120

gagccctact gtattgttag ccacctgcag gaggacaaga aatgcttcat atgtgactcc      180

cgagaccctt atcacgagac cctcaacccc gacagccatc tcattgagaa cgtggtcacc      240

acatttgctc caaaccgcct taagatctgg tggcaatcgg aaaatggtgt ggagaacgtg      300

accatccaac tggacctgga agcagaattc catttcactc atctcatcat gaccttcaag      360

acattccgcc cagccgccat gctgatcgag cggtcttctg actttgggaa gacttggggc      420

gtgtacagat acttcgccta cgactgtgag agctcgttcc caggcatttc aactggaccc      480

atgaagaaag tggatgacat catctgtgac tctcgatatt ctgacattga gccctcgaca      540

gaaggagagg taatatttcg tgctttagat cctgctttca aaattgaaga cccttatagt      600

ccaaggatac agaatctatt aaaaatcacc aacttgagaa tcaagtttgt gaaactgcac      660

accttggggg ataacctttt ggactccaga atggaaatcc gagagaagta ctattacgct      720

gtttatgata tggtggttcg aggg                                             744


<210>  96
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LN

<400>  96

Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu Gly Ser Cys Tyr Pro 
1               5                   10                  15      


Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln Lys Leu Ser Val Thr 
            20                  25                  30          


Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr Cys Ile Val Ser His 
        35                  40                  45              


Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asp Ser Arg Asp Pro Tyr 
    50                  55                  60                  


His Glu Thr Leu Asn Pro Asp Ser His Leu Ile Glu Asn Val Val Thr 
65                  70                  75                  80  


Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp Gln Ser Glu Asn Gly 
                85                  90                  95      


Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His Phe 
            100                 105                 110         


Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu 
        115                 120                 125             


Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Gly Val Tyr Arg Tyr 
    130                 135                 140                 


Phe Ala Tyr Asp Cys Glu Ser Ser Phe Pro Gly Ile Ser Thr Gly Pro 
145                 150                 155                 160 


Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser Arg Tyr Ser Asp Ile 
                165                 170                 175     


Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg Ala Leu Asp Pro Ala 
            180                 185                 190         


Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile Gln Asn Leu Leu Lys 
        195                 200                 205             


Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu His Thr Leu Gly Asp 
    210                 215                 220                 


Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu Lys Tyr Tyr Tyr Ala 
225                 230                 235                 240 


Val Tyr Asp Met Val Val Arg Gly 
                245             


<210>  97
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LN domain [DNA, 744 bp]

<400>  97
caggaacccg agttcagcta cggctgcgca gaaggcagct gctatcccgc cacgggcgac       60

cttctcatcg gccgagcaca gaagctttcg gtgacctcga cgtgcgggct gcacaagccc      120

gaaccctact gtatcgtcag ccacttgcag gaggacaaaa aatgcttcat atgcaattcc      180

caagatcctt atcatgagac cctgaatcct gacagccatc tcattgaaaa tgtggtcact      240

acatttgctc caaaccgcct taagatttgg tggcaatctg aaaatggtgt ggaaaatgta      300

actatccaac tggatttgga agcagaattc cattttactc atctcataat gactttcaag      360

acattccgtc cagctgctat gctgatagaa cgatcgtccg actttgggaa aacctggggt      420

gtgtatagat acttcgccta tgactgtgag gcctcgtttc caggcatttc aactggcccc      480

atgaaaaaag tcgatgacat aatttgtgat tctcgatatt ctgacattga accctcaact      540

gaaggagagg tgatatttcg tgctttagat cctgctttca aaatagaaga tccttatagc      600

ccaaggatac agaatttatt aaaaattacc aacttgagaa tcaagtttgt gaaactgcat      660

actttgggag ataaccttct ggattccagg atggaaatca gagaaaagta ttattatgca      720

gtttatgata tggtggttcg agga                                             744


<210>  98
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LN

<400>  98

Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu Gly Ser Cys Tyr Pro 
1               5                   10                  15      


Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln Lys Leu Ser Val Thr 
            20                  25                  30          


Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr Cys Ile Val Ser His 
        35                  40                  45              


Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn Ser Gln Asp Pro Tyr 
    50                  55                  60                  


His Glu Thr Leu Asn Pro Asp Ser His Leu Ile Glu Asn Val Val Thr 
65                  70                  75                  80  


Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp Gln Ser Glu Asn Gly 
                85                  90                  95      


Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His Phe 
            100                 105                 110         


Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu 
        115                 120                 125             


Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Gly Val Tyr Arg Tyr 
    130                 135                 140                 


Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly Ile Ser Thr Gly Pro 
145                 150                 155                 160 


Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser Arg Tyr Ser Asp Ile 
                165                 170                 175     


Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg Ala Leu Asp Pro Ala 
            180                 185                 190         


Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile Gln Asn Leu Leu Lys 
        195                 200                 205             


Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu His Thr Leu Gly Asp 
    210                 215                 220                 


Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu Lys Tyr Tyr Tyr Ala 
225                 230                 235                 240 


Val Tyr Asp Met Val Val Arg Gly 
                245             


<210>  99
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-1 domain [DNA, 192 bp]

<400>  99
aactgcttct gctatggcca cgccagtgaa tgcgcccctg tggatggagt caatgaagaa       60

gtggaaggaa tggttcacgg gcactgcatg tgcagacaca acaccaaagg cctgaactgt      120

gagctgtgca tggatttcta ccacgatttg ccgtggagac ctgctgaagg ccggaacagc      180

aacgcctgca aa                                                          192


<210>  100
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-1

<400>  100

Asn Cys Phe Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly 
1               5                   10                  15      


Val Asn Glu Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg 
            20                  25                  30          


His Asn Thr Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His 
        35                  40                  45              


Asp Leu Pro Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys 
    50                  55                  60                  


<210>  101
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-1 [DNA, 192 bp]

<400>  101
aattgcttct gctatggtca tgccagcgaa tgtgcccctg tggatggatt caatgaagaa       60

gtggaaggaa tggttcacgg acactgcatg tgcaggcata acaccaaggg cttaaactgt      120

gaactctgca tggatttcta ccatgattta ccttggagac ctgctgaagg ccgaaacagc      180

aacgcctgta aa                                                          192


<210>  102
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-1

<400>  102

Asn Cys Phe Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly 
1               5                   10                  15      


Phe Asn Glu Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg 
            20                  25                  30          


His Asn Thr Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His 
        35                  40                  45              


Asp Leu Pro Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys 
    50                  55                  60                  


<210>  103
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-2 domain [DNA, 189 bp]

<400>  103
aaatgtaact gcaatgaaca ttccagctcg tgtcactttg acatggcagt cttcctggct       60

actggcaacg tcagcggggg agtgtgtgat aactgtcagc acaacaccat ggggcgcaac      120

tgtgaacagt gcaaaccgtt ctacttccag caccctgaga gggacatccg ggaccccaat      180

ctctgtgaa                                                              189


<210>  104
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-2

<400>  104

Lys Cys Asn Cys Asn Glu His Ser Ser Ser Cys His Phe Asp Met Ala 
1               5                   10                  15      


Val Phe Leu Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asn Cys 
            20                  25                  30          


Gln His Asn Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr 
        35                  40                  45              


Phe Gln His Pro Glu Arg Asp Ile Arg Asp Pro Asn Leu Cys Glu 
    50                  55                  60              


<210>  105
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin  1 LEa-2 [DNA, 189 bp]

<400>  105
aaatgtaact gcaatgaaca ttccatctct tgtcactttg acatggctgt ttacctggcc       60

acggggaacg tcagcggagg cgtgtgtgat gactgtcagc acaacaccat ggggcgcaac      120

tgtgagcagt gcaagccgtt ttactaccag cacccagaga gggacatccg agatcctaat      180

ttctgtgaa                                                              189


<210>  106
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-

<400>  106

Lys Cys Asn Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala 
1               5                   10                  15      


Val Tyr Leu Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys 
            20                  25                  30          


Gln His Asn Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr 
        35                  40                  45              


Tyr Gln His Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu 
    50                  55                  60              


<210>  107
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-3 domain [DNA, 180 bp]

<400>  107
ccatgtacct gtgacccagc tggttctgag aatggcggga tctgtgatgg gtacactgat       60

ttttctgtgg gtctcattgc tggtcagtgt cggtgcaaat tgcacgtgga gggagagcgc      120

tgtgatgttt gtaaagaagg cttctacgac ttaagtgctg aagacccgta tggttgtaaa      180


<210>  108
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-3

<400>  108

Pro Cys Thr Cys Asp Pro Ala Gly Ser Glu Asn Gly Gly Ile Cys Asp 
1               5                   10                  15      


Gly Tyr Thr Asp Phe Ser Val Gly Leu Ile Ala Gly Gln Cys Arg Cys 
            20                  25                  30          


Lys Leu His Val Glu Gly Glu Arg Cys Asp Val Cys Lys Glu Gly Phe 
        35                  40                  45              


Tyr Asp Leu Ser Ala Glu Asp Pro Tyr Gly Cys Lys 
    50                  55                  60  


<210>  109
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-3 [DNA, 180 bp]

<400>  109
cgatgtacgt gtgacccagc tggctctcaa aatgagggaa tttgtgacag ctatactgat       60

ttttctactg gtctcattgc tggccagtgt cggtgtaaat taaatgtgga aggagaacat      120

tgtgatgttt gcaaagaagg cttctatgat ttaagcagtg aagatccatt tggttgtaaa      180


<210>  110
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-3

<400>  110

Arg Cys Thr Cys Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp 
1               5                   10                  15      


Ser Tyr Thr Asp Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys 
            20                  25                  30          


Lys Leu Asn Val Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe 
        35                  40                  45              


Tyr Asp Leu Ser Ser Glu Asp Pro Phe Gly Cys Lys 
    50                  55                  60  


<210>  111
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-4 domain [DNA, 156 bp]

<400>  111
tcatgtgctt gcaatcctct gggaacaatt cctggtggga atccttgtga ttctgagact       60

ggctactgct actgtaagcg cctggtgaca ggacagcgct gtgaccagtg cctgccgcag      120

cactggggtt taagcaatga tttggatggg tgtcga                                156


<210>  112
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 LEa-4

<400>  112

Ser Cys Ala Cys Asn Pro Leu Gly Thr Ile Pro Gly Gly Asn Pro Cys 
1               5                   10                  15      


Asp Ser Glu Thr Gly Tyr Cys Tyr Cys Lys Arg Leu Val Thr Gly Gln 
            20                  25                  30          


Arg Cys Asp Gln Cys Leu Pro Gln His Trp Gly Leu Ser Asn Asp Leu 
        35                  40                  45              


Asp Gly Cys Arg 
    50          


<210>  113
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-4 [DNA, 156 bp]

<400>  113
tcttgtgctt gcaatcctct gggaacaatt cctggaggga atccttgtga ttccgagaca       60

ggtcactgct actgcaagcg tctggtgaca ggacagcatt gtgaccagtg cctgccagag      120

cactggggct taagcaatga tttggatgga tgtcga                                156


<210>  114
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin beta 1 LEa-4

<400>  114

Ser Cys Ala Cys Asn Pro Leu Gly Thr Ile Pro Gly Gly Asn Pro Cys 
1               5                   10                  15      


Asp Ser Glu Thr Gly His Cys Tyr Cys Lys Arg Leu Val Thr Gly Gln 
            20                  25                  30          


His Cys Asp Gln Cys Leu Pro Glu His Trp Gly Leu Ser Asn Asp Leu 
        35                  40                  45              


Asp Gly Cys Arg 
    50          


<210>  115
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin beta 1 signal peptide [DNA, 99 bp]

<400>  115
atgacgggcg gcgggcgggc cgcgctggcc ctgcagcccc gggggcggct gtggccgctg       60

ttggctgtgc tggcggctgt ggcgggctgt gtccgggcg                              99


<210>  116
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 signal peptide

<400>  116

Met Thr Gly Gly Gly Arg Ala Ala Leu Ala Leu Gln Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Leu Leu Ala Val Leu Ala Ala Val Ala Gly Cys Val Arg 
            20                  25                  30          


Ala 
    


<210>  117
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 signal peptide [DNA, 99 bp]

<400>  117
atgagaggga gccatcgggc cgcgccggcc ctgcggcccc gggggcggct ctggcccgtg       60

ctggccgtgc tggcggcggc cgccgcggcg ggctgtgcc                              99


<210>  118
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMAN Laminin gamma 1 signal peptide:

<400>  118

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala 
    


<210>  119
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LN domain [DNA, 768 bp]       

<400>  119
gccatggact acaaggacga cgatgacaag gagtgcgcgg atgagggcgg gcggccgcag       60

cgctgcatgc cggagtttgt taatgccgcc ttcaatgtga ccgtggtggc taccaacacg      120

tgtgggactc cgcccgagga gtactgcgtg cagactgggg tgaccggagt cactaagtcc      180

tgtcacctgt gcgacgccgg ccagcagcac ctgcaacacg gggcagcctt cctgaccgac      240

tacaacaacc aggccgacac cacctggtgg caaagccaga ctatgctggc cggggtgcag      300

taccccaact ccatcaacct cacgctgcac ctgggaaagg cttttgacat cacttacgtg      360

cgcctcaagt tccacaccag ccgtccagag agcttcgcca tctataagcg cactcgggaa      420

gacgggccct ggattcctta tcagtactac agtgggtcct gtgagaacac gtactcaaag      480

gctaaccgtg gcttcatcag gaccggaggg gacgagcagc aggccttgtg tactgatgaa      540

ttcagtgaca tttcccccct caccggtggc aacgtggcct tttcaaccct ggaaggacgg      600

ccgagtgcct acaactttga caacagccct gtgctccagg aatgggtaac tgccactgac      660

atcagagtga cgctcaatcg cctgaacacc tttggagatg aagtgtttaa cgagcccaaa      720

gttctcaagt cttactatta cgcaatctca gactttgctg tgggcggc                   768


<210>  120
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LN domain

<400>  120

Ala Met Asp Glu Cys Ala Asp Glu Gly Gly Arg Pro Gln Arg Cys Met 
1               5                   10                  15      


Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val Ala Thr Asn 
            20                  25                  30          


Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr Gly Val Thr 
        35                  40                  45              


Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln Gln His Leu 
    50                  55                  60                  


Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln Ala Asp Thr 
65                  70                  75                  80  


Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln Tyr Pro Asn 
                85                  90                  95      


Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp Ile Thr Tyr 
            100                 105                 110         


Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe Ala Ile Tyr 
        115                 120                 125             


Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln Tyr Tyr Ser 
    130                 135                 140                 


Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly Phe Ile Arg 
145                 150                 155                 160 


Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu Phe Ser Asp 
                165                 170                 175     


Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr Leu Glu Gly 
            180                 185                 190         


Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu Gln Glu Trp 
        195                 200                 205             


Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu Asn Thr Phe 
    210                 215                 220                 


Gly Asp Glu Val Phe Asn Glu Pro Lys Val Leu Lys Ser Tyr Tyr Tyr 
225                 230                 235                 240 


Ala Ile Ser Asp Phe Ala Val Gly Gly 
                245                 


<210>  121
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LN domain [DNA, 753 bp]

<400>  121
caggcagcca tggacgagtg cacggacgag ggcgggcggc cgcaacgctg catgcccgag       60

ttcgtcaacg ccgctttcaa cgtgactgtg gtggccacca acacgtgtgg gactccgccc      120

gaggaatact gtgtgcagac cggggtgacc ggggtcacca agtcctgtca cctgtgcgac      180

gccgggcagc cccacctgca gcacggggca gccttcctga ccgactacaa caaccaggcc      240

gacaccacct ggtggcaaag ccagaccatg ctggccgggg tgcagtaccc cagctccatc      300

aacctcacgc tgcacctggg aaaagctttt gacatcacct atgtgcgtct caagttccac      360

accagccgcc cggagagctt tgccatttac aagcgcacat gggaagacgg gccctggatt      420

ccttaccagt actacagtgg ttcctgcgag aacacctact ccaaggcaaa ccgcggcttc      480

atcaggacag gaggggacga gcagcaggcc ttgtgtactg atgaattcag tgacatttct      540

cccctcactg ggggcaacgt ggccttttct accctggaag gaaggcccag cgcctataac      600

tttgacaata gccctgtgct gcaggaatgg gtaactgcca ctgacatcag tgtaactctt      660

aatcgcctga acacttttgg agatgaagtg tttaacgatc ccaaagttct caagtcctat      720

tattatgcca tctctgattt tgctgtaggt ggc                                   753


<210>  122
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LN domain

<400>  122

Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln Arg 
1               5                   10                  15      


Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val Ala 
            20                  25                  30          


Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr Gly 
        35                  40                  45              


Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln Pro 
    50                  55                  60                  


His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln Ala 
65                  70                  75                  80  


Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln Tyr 
                85                  90                  95      


Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp Ile 
            100                 105                 110         


Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe Ala 
        115                 120                 125             


Ile Tyr Lys Arg Thr Trp Glu Asp Gly Pro Trp Ile Pro Tyr Gln Tyr 
    130                 135                 140                 


Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly Phe 
145                 150                 155                 160 


Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu Phe 
                165                 170                 175     


Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr Leu 
            180                 185                 190         


Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu Gln 
        195                 200                 205             


Glu Trp Val Thr Ala Thr Asp Ile Ser Val Thr Leu Asn Arg Leu Asn 
    210                 215                 220                 


Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser Tyr 
225                 230                 235                 240 


Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly 
                245                 250     


<210>  123
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-1 domain [DNA, 68 bp] 

       (note: TGC for cys (Durkin, et al., Biochemistry 27 (14)

<400>  123
aggtgtaaat gtaacggaca tgccagcgag tgtgtaaaga acgagtttga caaactcatg       60

tgcaactgca aacataacac atacggagtt gactgtgaaa agtgcctgcc tttcttcaat      120

gaccggccgt ggaggagggc gactgctgag agcgccagcg agtgcctt                   168


<210>  124
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-1

<400>  124

Arg Cys Lys Cys Asn Gly His Ala Ser Glu Cys Val Lys Asn Glu Phe 
1               5                   10                  15      


Asp Lys Leu Met Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys 
            20                  25                  30          


Glu Lys Cys Leu Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr 
        35                  40                  45              


Ala Glu Ser Ala Ser Glu Cys Leu 
    50                  55      


<210>  125
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-1 [DNA, 168 bp]

<400>  125
agatgtaaat gtaatggaca cgcaagcgag tgtatgaaga acgaatttga taagctggtg       60

tgtaattgca aacataacac atatggagta gactgtgaaa agtgtcttcc tttcttcaat      120

gaccggccgt ggaggagggc aactgcggaa agtgccagtg aatgcctg                   168


<210>  126
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-1

<400>  126

Arg Cys Lys Cys Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe 
1               5                   10                  15      


Asp Lys Leu Val Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys 
            20                  25                  30          


Glu Lys Cys Leu Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr 
        35                  40                  45              


Ala Glu Ser Ala Ser Glu Cys Leu 
    50                  55      


<210>  127
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin  1 LEa-2 domain [DNA, 168 bp]

<400>  127
ccttgtgact gcaatggccg atcccaagag tgctactttg atcctgaact ataccgttcc       60

actggacatg gtggccactg taccaactgc cgggataaca cagatggtgc caagtgcgag      120

aggtgccggg agaatttctt ccgcctgggg aacactgaag cctgctct                   168


<210>  128
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-2

<400>  128

Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr Phe Asp Pro Glu 
1               5                   10                  15      


Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr Asn Cys Arg Asp 
            20                  25                  30          


Asn Thr Asp Gly Ala Lys Cys Glu Arg Cys Arg Glu Asn Phe Phe Arg 
        35                  40                  45              


Leu Gly Asn Thr Glu Ala Cys Ser 
    50                  55      


<210>  129
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-2 [DNA, 168 bp]

<400>  129
ccctgtgatt gcaatggtcg atcccaggaa tgctacttcg accctgaact ctatcgttcc       60

actggccatg ggggccactg taccaactgc caggataaca cagatggcgc ccactgtgag      120

aggtgccgag agaacttctt ccgccttggc aacaatgaag cctgctct                   168


<210>  130
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-2

<400>  130

Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr Phe Asp Pro Glu 
1               5                   10                  15      


Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr Asn Cys Gln Asp 
            20                  25                  30          


Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu Asn Phe Phe Arg 
        35                  40                  45              


Leu Gly Asn Asn Glu Ala Cys Ser 
    50                  55      


<210>  131
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-3 domain [DNA, 141 bp]

<400>  131
ccgtgccact gcagccctgt tggttctctc agcacacagt gtgacagtta cggcagatgc       60

agctgtaagc caggagtgat gggtgacaag tgtgaccgtt gtcagcctgg gttccattcc      120

ctcactgagg caggatgcag g                                                141


<210>  132
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-3

<400>  132

Pro Cys His Cys Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser 
1               5                   10                  15      


Tyr Gly Arg Cys Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp 
            20                  25                  30          


Arg Cys Gln Pro Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg 
        35                  40                  45          


<210>  133
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-3 [DNA, 141 bp]

<400>  133
tcatgccact gtagtcctgt gggctctcta agcacacagt gtgatagtta cggcagatgc       60

agctgtaagc caggagtgat gggggacaaa tgtgaccgtt gccagcctgg attccattct      120

ctcactgaag caggatgcag g                                                141


<210>  134
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-3

<400>  134

Ser Cys His Cys Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser 
1               5                   10                  15      


Tyr Gly Arg Cys Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp 
            20                  25                  30          


Arg Cys Gln Pro Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg 
        35                  40                  45          


<210>  135
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-4 [DNA, 150 bp]

<400>  135
ccatgctcct gcgatcttcg gggcagcaca gacgagtgta atgttgaaac aggaagatgc       60

gtttgcaaag acaatgttga aggcttcaac tgtgagagat gcaaacctgg attttttaat      120

ctggagtcat ctaatcctaa gggctgcaca                                       150


<210>  136
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Laminin gamma 1 LEa-4

<400>  136

Pro Cys Ser Cys Asp Leu Arg Gly Ser Thr Asp Glu Cys Asn Val Glu 
1               5                   10                  15      


Thr Gly Arg Cys Val Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu 
            20                  25                  30          


Arg Cys Lys Pro Gly Phe Phe Asn Leu Glu Ser Ser Asn Pro Lys Gly 
        35                  40                  45              


Cys Thr 
    50  


<210>  137
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-4 [DNA, 150 bp]

<400>  137
ccatgctctt gtgatccctc tggcagcata gatgaatgta atgttgaaac aggaagatgt       60

gtttgcaaag acaatgtcga aggcttcaat tgtgaaagat gcaaacctgg attttttaat      120

ctggaatcat ctaatcctcg gggttgcaca                                       150


<210>  138
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Laminin gamma 1 LEa-4

<400>  138

Pro Cys Ser Cys Asp Pro Ser Gly Ser Ile Asp Glu Cys Asn Val Glu 
1               5                   10                  15      


Thr Gly Arg Cys Val Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu 
            20                  25                  30          


Arg Cys Lys Pro Gly Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly 
        35                  40                  45              


Cys Thr 
    50  


<210>  139
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG1 domain [DNA, 531 bp]

<400>  139
ccctctgtgc cagcttttaa gggccactcc ttcttggcct tccccaccct ccgagcctac       60

cacacgctgc gtctggcact agaattccgg gcgctggaga cagagggact gctgctctac      120

aatggcaatg cacgtggcaa agatttcctg gctctggctc tgttggatgg tcatgtacag      180

ttcaggttcg acacgggctc agggccggcg gtgctaacaa gcttagtgcc agtggaaccg      240

ggacggtggc accgcctcga gttgtcacgg cattggcggc agggcacact ttctgtggat      300

ggcgaggctc ctgttgtagg tgaaagtccg agtggcactg atggcctcaa cttggacacg      360

aagctctatg tgggtggtct cccagaagaa caagttgcca cggtgcttga tcggacctct      420

gtgggcatcg gcctgaaagg atgcattcgt atgttggaca tcaacaacca gcagctggag      480

ctgagcgatt ggcagagggc tgtggttcaa agctctggtg tgggggaatg c               531


<210>  140
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG1 domain

<400>  140

Pro Ser Val Pro Ala Phe Lys Gly His Ser Phe Leu Ala Phe Pro Thr 
1               5                   10                  15      


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
            20                  25                  30          


Glu Thr Glu Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
        35                  40                  45              


Phe Leu Ala Leu Ala Leu Leu Asp Gly His Val Gln Phe Arg Phe Asp 
    50                  55                  60                  


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Leu Val Pro Val Glu Pro 
65                  70                  75                  80  


Gly Arg Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Gln Gly Thr 
                85                  90                  95      


Leu Ser Val Asp Gly Glu Ala Pro Val Val Gly Glu Ser Pro Ser Gly 
            100                 105                 110         


Thr Asp Gly Leu Asn Leu Asp Thr Lys Leu Tyr Val Gly Gly Leu Pro 
        115                 120                 125             


Glu Glu Gln Val Ala Thr Val Leu Asp Arg Thr Ser Val Gly Ile Gly 
    130                 135                 140                 


Leu Lys Gly Cys Ile Arg Met Leu Asp Ile Asn Asn Gln Gln Leu Glu 
145                 150                 155                 160 


Leu Ser Asp Trp Gln Arg Ala Val Val Gln Ser Ser Gly Val Gly Glu 
                165                 170                 175     


Cys 
    


<210>  141
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Agrin LG1 [DNA, 531 bp]

<400>  141
gcccctgtgc cggccttcga gggccgctcc ttcctggcct tccccactct ccgcgcctac       60

cacacgctgc gcctggcact ggaattccgg gcgctggagc ctcaggggct gctgctgtac      120

aatggcaacg cccggggcaa ggacttcctg gcattggcgc tgctagatgg ccgcgtgcag      180

ctcaggtttg acacaggttc ggggccggcg gtgctgacca gtgccgtgcc ggtagagccg      240

ggccagtggc accgcctgga gctgtcccgg cactggcgcc ggggcaccct ctcggtggat      300

ggtgagaccc ctgttctggg cgagagtccc agtggcaccg acggcctcaa cctggacaca      360

gacctctttg tgggcggcgt acccgaggac caggctgccg tggcgctgga gcggaccttc      420

gtgggcgccg gcctgagggg gtgcatccgt ttgctggacg tcaacaacca gcgcctggag      480

cttggcattg ggccgggggc tgccacccga ggctctggcg tgggcgagtg c               531


<210>  142
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin LG1

<400>  142

Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
1               5                   10                  15      


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
            20                  25                  30          


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
        35                  40                  45              


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
    50                  55                  60                  


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
65                  70                  75                  80  


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
                85                  90                  95      


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
            100                 105                 110         


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
        115                 120                 125             


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
    130                 135                 140                 


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
145                 150                 155                 160 


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
                165                 170                 175     


Cys 
    


<210>  143
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 2 [DNA, 114 bp]

<400>  143
ggagaccatc cctgctcacc taacccctgc catggcgggg ccctctgcca ggccctggag       60

gctggcgtgt tcctctgtca gtgcccacct ggccgctttg gcccaacttg tgca            114


<210>  144
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 2

<400>  144

Gly Asp His Pro Cys Ser Pro Asn Pro Cys His Gly Gly Ala Leu Cys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Gly Val Phe Leu Cys Gln Cys Pro Pro Gly Arg 
            20                  25                  30          


Phe Gly Pro Thr Cys Ala 
        35              


<210>  145
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human agrin EGF-like domain 2 [DNA, 114 bp]

<400>  145
ggggaccacc cctgcctgcc caacccctgc catggcgggg ccccatgcca gaacctggag       60

gctggaaggt tccattgcca gtgcccgccc ggccgcgtcg gaccaacctg tgcc            114


<210>  146
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin EGF-like 2

<400>  146

Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro Cys 
1               5                   10                  15      


Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly Arg 
            20                  25                  30          


Val Gly Pro Thr Cys Ala 
        35              


<210>  147
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 3 [DNA, 117 bp]

<400>  147
gatgaaaaga acccctgcca accgaacccc tgccacgggt cagccccctg ccatgtgctt       60

tccaggggtg gggccaagtg tgcgtgcccc ctgggacgca gtggttcctt ctgtgag         117


<210>  148
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 3

<400>  148

Asp Glu Lys Asn Pro Cys Gln Pro Asn Pro Cys His Gly Ser Ala Pro 
1               5                   10                  15      


Cys His Val Leu Ser Arg Gly Gly Ala Lys Cys Ala Cys Pro Leu Gly 
            20                  25                  30          


Arg Ser Gly Ser Phe Cys Glu 
        35                  


<210>  149
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Agrin EGF-like 3 [DNA, 117 bp]

<400>  149
gatgagaaga gcccctgcca gcccaacccc tgccatgggg cggcgccctg ccgtgtgctg       60

cccgagggtg gtgctcagtg cgagtgcccc ctggggcgtg agggcacctt ctgccag         117


<210>  150
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin EGF-like 3

<400>  150

Asp Glu Lys Ser Pro Cys Gln Pro Asn Pro Cys His Gly Ala Ala Pro 
1               5                   10                  15      


Cys Arg Val Leu Pro Glu Gly Gly Ala Gln Cys Glu Cys Pro Leu Gly 
            20                  25                  30          


Arg Glu Gly Thr Phe Cys Gln 
        35                  


<210>  151
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG Spacer-1 [DNA, 27 bp]

<400>  151
acagtcctgg agaatgctgg ctcccgg                                           27


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin spacer domain-1

<400>  152

Thr Val Leu Glu Asn Ala Gly Ser Arg 
1               5                   


<210>  153
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human spacer [DNA, 27 bp]

<400>  153
acagcctcgg ggcaggacgg ctctggg                                           27


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human spacer

<400>  154

Thr Ala Ser Gly Gln Asp Gly Ser Gly 
1               5                   


<210>  155
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG2 domain [DNA, 537 bp]

<400>  155
cccttcctgg ctgactttaa tggcttctcc tacctggaac tgaaaggctt gcacaccttc       60

gagagagacc taggggagaa gatggcgctg gagatggtgt tcttggctcg tgggcccagt      120

ggcttactcc tctacaatgg gcagaagacg gatggcaagg gggactttgt atccctggcc      180

ctgcataacc ggcacctaga gttccgctat gaccttggca agggggctgc aatcatcagg      240

agcaaagagc ccatagccct gggcacctgg gttagggtat tcctggaacg aaatggccgc      300

aagggtgccc ttcaagtggg tgatgggccc cgtgtgctag gggaatctcc ggtcccgcac      360

accatgctca acctcaagga gcccctctat gtggggggag ctcctgactt cagcaagctg      420

gctcggggcg ctgcagtggc ctccggcttt gatggtgcca tccagctggt gtctctaaga      480

ggccatcagc tgctgactca ggagcatgtg ttgcgggcag tagatgtagc gcctttt         537


<210>  156
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG2 domain

<400>  156

Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser Tyr Leu Glu Leu Lys Gly 
1               5                   10                  15      


Leu His Thr Phe Glu Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Met 
            20                  25                  30          


Val Phe Leu Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn Gly Gln 
        35                  40                  45              


Lys Thr Asp Gly Lys Gly Asp Phe Val Ser Leu Ala Leu His Asn Arg 
    50                  55                  60                  


His Leu Glu Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Ile Ile Arg 
65                  70                  75                  80  


Ser Lys Glu Pro Ile Ala Leu Gly Thr Trp Val Arg Val Phe Leu Glu 
                85                  90                  95      


Arg Asn Gly Arg Lys Gly Ala Leu Gln Val Gly Asp Gly Pro Arg Val 
            100                 105                 110         


Leu Gly Glu Ser Pro Val Pro His Thr Met Leu Asn Leu Lys Glu Pro 
        115                 120                 125             


Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Gly Ala 
    130                 135                 140                 


Ala Val Ala Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu Arg 
145                 150                 155                 160 


Gly His Gln Leu Leu Thr Gln Glu His Val Leu Arg Ala Val Asp Val 
                165                 170                 175     


Ala Pro Phe 
            


<210>  157
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Agrin G2 [DNA, 537 bp]

<400>  157
cccttcctgg ctgacttcaa cggcttctcc cacctggagc tgagaggcct gcacaccttt       60

gcacgggacc tgggggagaa gatggcgctg gaggtcgtgt tcctggcacg aggccccagc      120

ggcctcctgc tctacaacgg gcagaagacg gacggcaagg gggacttcgt gtcgctggca      180

ctgcgggacc gccgcctgga gttccgctac gacctgggca agggggcagc ggtcatcagg      240

agcagggagc cagtcaccct gggagcctgg accagggtct cactggagcg aaacggccgc      300

aagggtgccc tgcgtgtggg cgacggcccc cgtgtgttgg gggagtcccc ggttccgcac      360

accgtcctca acctgaagga gccgctctac gtagggggcg ctcccgactt cagcaagctg      420

gcccgtgctg ctgccgtgtc ctctggcttc gacggtgcca tccagctggt ctccctcgga      480

ggccgccagc tgctgacccc ggagcacgtg ctgcggcagg tggacgtcac gtccttt         537


<210>  158
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin LG2

<400>  158

Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly 
1               5                   10                  15      


Leu His Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val 
            20                  25                  30          


Val Phe Leu Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn Gly Gln 
        35                  40                  45              


Lys Thr Asp Gly Lys Gly Asp Phe Val Ser Leu Ala Leu Arg Asp Arg 
    50                  55                  60                  


Arg Leu Glu Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg 
65                  70                  75                  80  


Ser Arg Glu Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser Leu Glu 
                85                  90                  95      


Arg Asn Gly Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val 
            100                 105                 110         


Leu Gly Glu Ser Pro Val Pro His Thr Val Leu Asn Leu Lys Glu Pro 
        115                 120                 125             


Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala Ala 
    130                 135                 140                 


Ala Val Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu Gly 
145                 150                 155                 160 


Gly Arg Gln Leu Leu Thr Pro Glu His Val Leu Arg Gln Val Asp Val 
                165                 170                 175     


Thr Ser Phe 
            


<210>  159
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 4 [DNA, 120 bp]

<400>  159
gcaggccacc cttgtaccca ggccgtggac aacccctgcc ttaatggggg ctcctgtatc       60

ccgagggaag ccacttatga gtgcctgtgt cctgggggct tctctgggct gcactgcgag      120


<210>  160
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin EGF-like domain 4

<400>  160

Ala Gly His Pro Cys Thr Gln Ala Val Asp Asn Pro Cys Leu Asn Gly 
1               5                   10                  15      


Gly Ser Cys Ile Pro Arg Glu Ala Thr Tyr Glu Cys Leu Cys Pro Gly 
            20                  25                  30          


Gly Phe Ser Gly Leu His Cys Glu 
        35                  40  


<210>  161
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Agrin Egf-like 4 [DNA, 120 bp]

<400>  161
gcaggtcacc cctgcacccg ggcctcaggc cacccctgcc tcaatggggc ctcctgcgtc       60

ccgagggagg ctgcctatgt gtgcctgtgt cccgggggat tctcaggacc gcactgcgag      120


<210>  162
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin EGF-like 4

<400>  162

Ala Gly His Pro Cys Thr Arg Ala Ser Gly His Pro Cys Leu Asn Gly 
1               5                   10                  15      


Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly 
            20                  25                  30          


Gly Phe Ser Gly Pro His Cys Glu 
        35                  40  


<210>  163
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG Spacer-2 [DNA, 30 bp]

<400>  163
aaggggatag ttgagaagtc agtgggggac                                        30


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG Spacer-2

<400>  164

Lys Gly Ile Val Glu Lys Ser Val Gly Asp 
1               5                   10  


<210>  165
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Spacer [30 bp]

<400>  165
aaggggctgg tggagaagtc agcgggggac                                        30


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Spacer

<400>  166

Lys Gly Leu Val Glu Lys Ser Ala Gly Asp 
1               5                   10  


<210>  167
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG3 domain [DNA, 537 bp]

<400>  167
ctagaaacac tggcctttga tgggcggacc tacatcgagt acctcaatgc tgtgactgag       60

agtgagaaag cgctgcagag caaccacttt gagctgagct tacgcactga ggccacgcag      120

gggctggtgc tgtggattgg aaaggttgga gaacgtgcag actacatggc tctggccatt      180

gtggatgggc acctacaact gagctatgac ctaggctccc agccagttgt gctgcgctcc      240

actgtgaagg tcaacaccaa ccgctggctt cgagtcaggg ctcacaggga gcacagggaa      300

ggttcccttc aggtgggcaa tgaagcccct gtgactggct cttccccgct gggtgccaca      360

caattggaca cagatggagc cctgtggctt ggaggcctac agaagcttcc tgtggggcag      420

gctctcccca aggcctatgg cacgggtttt gtgggctgtc tgcgggacgt ggtagtgggc      480

catcgccagc tgcatctgct ggaggacgct gtcaccaaac cagagctaag accctgc         537


<210>  168
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse agrin LG3 domain

<400>  168

Leu Glu Thr Leu Ala Phe Asp Gly Arg Thr Tyr Ile Glu Tyr Leu Asn 
1               5                   10                  15      


Ala Val Thr Glu Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu 
            20                  25                  30          


Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu Val Leu Trp Ile Gly Lys 
        35                  40                  45              


Val Gly Glu Arg Ala Asp Tyr Met Ala Leu Ala Ile Val Asp Gly His 
    50                  55                  60                  


Leu Gln Leu Ser Tyr Asp Leu Gly Ser Gln Pro Val Val Leu Arg Ser 
65                  70                  75                  80  


Thr Val Lys Val Asn Thr Asn Arg Trp Leu Arg Val Arg Ala His Arg 
                85                  90                  95      


Glu His Arg Glu Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr 
            100                 105                 110         


Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu 
        115                 120                 125             


Trp Leu Gly Gly Leu Gln Lys Leu Pro Val Gly Gln Ala Leu Pro Lys 
    130                 135                 140                 


Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly 
145                 150                 155                 160 


His Arg Gln Leu His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu 
                165                 170                 175     


Arg Pro Cys 
            


<210>  169
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Agrin LG3 [DNA, 537 bp]

<400>  169
gtggatacct tggcctttga cgggcggacc tttgtcgagt acctcaacgc tgtgaccgag       60

agcgagaagg cactgcagag caaccacttt gaactgagcc tgcgcactga ggccacgcag      120

gggctggtgc tctggagtgg caaggccacg gagcgggcag actatgtggc actggccatt      180

gtggacgggc acctgcaact gagctacaac ctgggctccc agcccgtggt gctgcgttcc      240

accgtgcccg tcaacaccaa ccgctggttg cgggtcgtgg cacataggga gcagagggaa      300

ggttccctgc aggtgggcaa tgaggcccct gtgaccggct cctccccgct gggcgccacg      360

cagctggaca ctgatggagc cctgtggctt gggggcctgc cggagctgcc cgtgggccca      420

gcactgccca aggcctacgg cacaggcttt gtgggctgct tgcgggacgt ggtggtgggc      480

cggcacccgc tgcacctgct ggaggacgcc gtcaccaagc cagagctgcg gccctgc         537


<210>  170
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Agrin LG3

<400>  170

Val Asp Thr Leu Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn 
1               5                   10                  15      


Ala Val Thr Glu Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu 
            20                  25                  30          


Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys 
        35                  40                  45              


Ala Thr Glu Arg Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His 
    50                  55                  60                  


Leu Gln Leu Ser Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser 
65                  70                  75                  80  


Thr Val Pro Val Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg 
                85                  90                  95      


Glu Gln Arg Glu Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr 
            100                 105                 110         


Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu 
        115                 120                 125             


Trp Leu Gly Gly Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys 
    130                 135                 140                 


Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly 
145                 150                 155                 160 


Arg His Pro Leu His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu 
                165                 170                 175     


Arg Pro Cys 
            


