                         SEQUENCE LISTING

<110>  NEURACLE SCIENCE CO., LTD.
       SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
 
<120>  ANTI-FAMILY WITH SEQUENCE SIMILARITY 19, MEMBER A5 ANTIBODIES AND
       METHOD OF USE THEREOF

<130>  3763.011PC02/C-K/DKC

<150>  US 62/669,648
<151>  2018-05-10

<150>  US 62/838,187
<151>  2019-04-24

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FAM19A5 Isoform 1

<400>  1

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Val Ser 
    130         


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FAM19A5 Isoform 2

<400>  2

Met Gln Leu Leu Lys Ala Leu Trp Ala Leu Ala Gly Ala Ala Leu Cys 
1               5                   10                  15      


Cys Phe Leu Val Leu Val Ile His Ala Gln Phe Leu Lys Glu Gly Gln 
            20                  25                  30          


Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg Asp Ser Ser 
        35                  40                  45              


Gln Pro Arg Arg Thr Ile Ala Arg Gln Thr Ala Arg Cys Ala Cys Arg 
    50                  55                  60                  


Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala Cys Val Asp 
65                  70                  75                  80  


Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu 
                85                  90                  95      


Glu Gly Glu Gly Cys Asp Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys 
            100                 105                 110         


Thr Gln Pro Gly Gly Arg Ile Lys Thr Thr Thr Val Ser 
        115                 120                 125 


<210>  3
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FAM19A5 Isoform 3

<400>  3

Met Tyr His His Arg Glu Trp Pro Ala Arg Ile Ile Lys Thr Lys Gln 
1               5                   10                  15      


Trp Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu 
            20                  25                  30          


Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys 
        35                  40                  45              


Thr Thr Thr Val Ser 
    50              


<210>  4
<211>  1501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human FAM19A5

<400>  4
ggcggcggag gatggcgcgc gcggggcccg cacgtggagg ccggcgcggg ggcgcgggca       60

gggccggctg ctgagacgcg ctgctgcccc ccgcgcgggc gccgcggctt caatggcgcc      120

atcgcccagg accggcagcc ggcaagatgc gaccgccctg cccagcatgt cctcaacttt      180

ctgggcgttc atgatcctgg ccagcctgct catcgcctac tgcagtcagc tggccgccgg      240

cacctgtgag attgtgacct tggaccggga cagcagccag cctcggagga cgatcgcccg      300

gcagaccgcc cgctgtgcgt gtagaaaggg gcagatcgcc ggcaccacga gagcccggcc      360

cgcctgtgtg gacgcaagaa tcatcaagac caagcagtgg tgtgacatgc ttccgtgtct      420

ggagggggaa ggctgcgact tgttaatcaa ccggtcaggc tggacgtgca cgcagcccgg      480

cgggaggata aagaccacca cggtctcctg acaaacacag cccctgaggg ggccccggga      540

gtggccttgg ctccctggag agcccacgtc tcagccacag ttctccactc gcctcggact      600

tcacccgttc tctgccgccc gcccactccg tttccctgtg gtccgtgaag gacggcctca      660

ggccttggca tcctgagctt cggtctgtcc agccgacccg aggaggccgg actcagacac      720

ataggcgggg ggcggcacct ggcatcagca atacgcagtc tgtgggagcc cggccgcgcc      780

cagcccccgc cgaccgtggc gttggccctg ctgtcctcag aggaggagga ggaggaggca      840

gctccggcag ccacagaagg ctgcagccca gcccgcctga gacacgacgc ctgccccagg      900

ggactgtcag gcacagaagc ggcctcctcc cgtgccccag actgtccgaa ttgcttttat      960

tttcttatac tttcagtata ctccatagac caaagagcaa aatctatctg aacctggacg     1020

caccctcact gtcagggtcc ctggggtcgc ttgtgcgggc gggagggcaa tggtggcaga     1080

gacatgctgg tggccccggc ggagcggaga gggcggccgt ggtggaggcc tccaccccag     1140

gagcaccccg cacaccctcg gaggacgggc ttcggctgcg cggaggccgt ggcacacctg     1200

cgggaggcag cgacggcccc cacgcagacg ccgggaacgc aggccgcttt attcctctgt     1260

acttagatca acttgaccgt actaaaatcc ctttctgttt taaccagtta aacatgcctc     1320

ttctacagct ccatttttga tagttggata atccagtatc tgccaagagc atgttgggtc     1380

tcccgtgact gctgcctcat cgatacccca tttagctcca gaaagcaaag aaaactcgag     1440

taacacttgt ttgaaagaga tcattaaatg tattttgcaa agcccaaaaa aaaaaaaaaa     1500

a                                                                     1501


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 and SS01-13 Antibody VH-CDR1

<400>  5

Ser Tyr Gln Met Gly 
1               5   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65  and SS01-13 Antibody VH-CDR2

<400>  6

Val Ile Asn Lys Ser Gly Ser Asp Thr Ser 
1               5                   10  


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 and SS01-13 Antibody VH-CDR3

<400>  7

Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala 
1               5                   10              


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VL-CDR1

<400>  8

Ser Gly Gly Gly Ser Ser Gly Tyr Gly Tyr Gly 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VL-CDR2

<400>  9

Trp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 and SS01-13 Antibody VL-CDR3

<400>  10

Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr Val Gly Val 
1               5                   10                  


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VH

<400>  11

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VL

<400>  12

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Ser Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Trp 
        35                  40                  45              


Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Ser Thr His Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly 
                85                  90                  95      


Tyr Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105                 110 


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VL-CDR1

<400>  13

Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VL-CDR2

<400>  14

Lys Asp Asp Glu Arg Pro Ser 
1               5           


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope F5

<400>  15

Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
1               5                   10                  15      


Asn Arg Ser Gly 
            20  


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope EP7

<400>  16

Gly Cys Asp Leu Leu Ile Asn Arg 
1               5               


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VH

<400>  17

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  18
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VL

<400>  18

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Arg Ile Thr Cys Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Lys Asp 
        35                  40                  45              


Asp Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Thr His Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr 
                85                  90                  95      


Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105                 


<210>  19
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-65 scFv

<400>  19

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Ser Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Trp 
        35                  40                  45              


Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Ser Thr His Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly 
                85                  90                  95      


Tyr Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Ser Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
    130                 135                 140                 


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
145                 150                 155                 160 


Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Gly Val Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val 
            180                 185                 190         


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
        195                 200                 205             


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp 
225                 230                 235                 240 


Gly His Gly Thr Glu Val Ile Val Ser Ser 
                245                 250 


<210>  20
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13 scFv

<400>  20

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Arg Ile Thr Cys Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Lys Asp 
        35                  40                  45              


Asp Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Thr His Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr 
                85                  90                  95      


Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser 
            100                 105                 110         


Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala 
        115                 120                 125             


Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala 
    130                 135                 140                 


Leu Ser Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gln 
145                 150                 155                 160 


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
                165                 170                 175     


Val Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val Lys 
            180                 185                 190         


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp Gly 
225                 230                 235                 240 


His Gly Thr Glu Val Ile Val Ser Ser 
                245                 


<210>  21
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VH

<400>  21
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctctctctc       60

tcttgcaaag cctccgggtt caccttcagc agctatcaga tgggctgggt gcgacaggcg      120

cccggcaagg ggctggaatg ggtcggtgtt attaacaagt ctggtagtga cacatcatac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtac      240

ctgcagatga acaacctcag ggctgaggac accgctgttt acttctgcgc caaaggttct      300

gctagttaca taactgctgc taccatcgac gcatggggcc acgggaccga agtcatcgtc      360

tcctcc                                                                 366


<210>  22
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13 Antibody VL

<400>  22
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgttcg tatcacctgc       60

tccgggggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agacgacgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcactg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtccta                                          327


<210>  23
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VH

<400>  23
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctcagcctc       60

gtctgcaagg cctccgggtt caccttcagc agctatcaga tgggctgggt gcgacaggcg      120

cccggcaagg ggctggaatg ggtcggtgtt attaacaaga gtggtagtga cacatcatac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacagtgagg      240

ctgcagctga acaacctcag ggctgaggac accggcacct acttctgcgc caaaggttct      300

gctagttata taactgctgc taccatcgac gcatggggcc acgggaccga agtcatcgtc      360

tcctcc                                                                 366


<210>  24
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-65 Antibody VL

<400>  24
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgtcaa gatcacctgc       60

tccgggggtg gtagcagtgg ctatggttat ggctggtatc agcagaagtc acctagcagt      120

gcccctctca ctgtgatcta ctggaacgac aagagaccct cggacatccc ttcacgattc      180

tccggttcca aatccggctc cacacacaca ttaaccatca ctggggtcca agccgaggac      240

gaggctgtat atttctgtgg gaatgatgac tacagcagtg atagtggata tgtcggtgta      300

tttggggccg ggacaaccct gaccgtccta                                       330


<210>  25
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-65 scFv

<400>  25
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgtcaa gatcacctgc       60

tccgggggtg gtagcagtgg ctatggttat ggctggtatc agcagaagtc acctagcagt      120

gcccctctca ctgtgatcta ctggaacgac aagagaccct cggacatccc ttcacgattc      180

tccggttcca aatccggctc cacacacaca ttaaccatca ctggggtcca agccgaggac      240

gaggctgtat atttctgtgg gaatgatgac tacagcagtg atagtggata tgtcggtgta      300

tttggggccg ggacaaccct gaccgtccta ggtcagtcct ctagatcttc cggcggtggt      360

ggcagctccg gtggtggcgg ttccgccgtg acgttggacg agtccggggg cggcctccag      420

acgcccggag gagcgctcag cctcgtctgc aaggcctccg ggttcacctt cagcagctat      480

cagatgggct gggtgcgaca ggcgcccggc aaggggctgg aatgggtcgg tgttattaac      540

aagagtggta gtgacacatc atacgggtcg gcggtgaagg gccgtgccac catctcgagg      600

gacaacgggc agagcacagt gaggctgcag ctgaacaacc tcagggctga ggacaccggc      660

acctacttct gcgccaaagg ttctgctagt tatataactg ctgctaccat cgacgcatgg      720

ggccacggga ccgaagtcat cgtctcctcc                                       750


<210>  26
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13 scFv

<400>  26
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgttcg tatcacctgc       60

tccgggggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agacgacgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcactg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtcctaggt cagtcctcta gatcttccgg cggtggtggc      360

agctccggtg gtggcggttc cgccgtgacg ttggacgagt ccgggggcgg cctccagacg      420

cccggaggag cgctctctct ctcttgcaaa gcctccgggt tcaccttcag cagctatcag      480

atgggctggg tgcgacaggc gcccggcaag gggctggaat gggtcggtgt tattaacaag      540

tctggtagtg acacatcata cgggtcggcg gtgaagggcc gtgccaccat ctcgagggac      600

aacgggcaga gcacactgta cctgcagatg aacaacctca gggctgagga caccgctgtt      660

tacttctgcg ccaaaggttc tgctagttac ataactgctg ctaccatcga cgcatggggc      720

cacgggaccg aagtcatcgt ctcctcc                                          747


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5 VH-CDR2

<400>  27

Ala Ile Asn Lys Ser Gly Ser Asp Thr Ser 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S5-SG VH-CDR2

<400>  28

Ala Ile Asn Lys Gly Gly Ser Asp Thr Ser 
1               5                   10  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5; S5-SG VL-CDR2

<400>  29

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5 VH

<400>  30

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S5-SG VH

<400>  31

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Lys Gly Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  32
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5; S5-SG VL

<400>  32

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Arg Ile Thr Cys Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Lys Asp 
        35                  40                  45              


Ser Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Thr His Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr 
                85                  90                  95      


Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105                 


<210>  33
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5 scFv

<400>  33

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Arg Ile Thr Cys Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Lys Asp 
        35                  40                  45              


Ser Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Thr His Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr 
                85                  90                  95      


Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser 
            100                 105                 110         


Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala 
        115                 120                 125             


Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala 
    130                 135                 140                 


Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gln 
145                 150                 155                 160 


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Asn Lys Ser Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val Lys 
            180                 185                 190         


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp Gly 
225                 230                 235                 240 


His Gly Thr Glu Val Ile Val Ser Ser 
                245                 


<210>  34
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S5-SG scFv

<400>  34

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Ala 
1               5                   10                  15      


Arg Ile Thr Cys Ser Gly Gly Ala Ser Ser Gly Tyr Gly Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Ser Ser Ala Pro Leu Thr Val Ile Tyr Lys Asp 
        35                  40                  45              


Ser Glu Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Thr His Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Asn Asp Asp Tyr Ser Ser Asp Ser Gly Tyr 
                85                  90                  95      


Val Gly Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Ser 
            100                 105                 110         


Ser Arg Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ala 
        115                 120                 125             


Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala 
    130                 135                 140                 


Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gln 
145                 150                 155                 160 


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Asn Lys Gly Gly Ser Asp Thr Ser Tyr Gly Ser Ala Val Lys 
            180                 185                 190         


Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Lys Gly Ser Ala Ser Tyr Ile Thr Ala Ala Thr Ile Asp Ala Trp Gly 
225                 230                 235                 240 


His Gly Thr Glu Val Ile Val Ser Ser 
                245                 


<210>  35
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5 VH

<400>  35
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

tcttgcaagg cctccgggtt caccttcagc agctatcaga tgggctgggt gcgacaggcg      120

cccggcaagg ggctggaatg ggtcagcgcg attaataaga gcggtagtga cacatcatac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtac      240

ctgcagatga acagcctcag ggctgaggac accgctgttt acttctgcgc caaaggttct      300

gctagttaca taactgctgc taccatcgac gcatggggcc acgggaccga agtcatcgtc      360

tcctcc                                                                 366


<210>  36
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S5-SG VH

<400>  36
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctccgcctc       60

tcttgcaagg cctccgggtt caccttcagc agctatcaga tgggctgggt gcgacaggcg      120

cccggcaagg ggctggaatg ggtcagcgcg attaataagg gcggtagtga cacatcatac      180

gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgtac      240

ctgcagatga acagcctcag ggctgaggac accgctgttt acttctgcgc caaaggttct      300

gctagttaca taactgctgc taccatcgac gcatggggcc acgggaccga agtcatcgtc      360

tcctcc                                                                 366


<210>  37
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13-s5 VL

<400>  37
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgcgcg tatcacctgc       60

tccggtggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agactctgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcagcg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtccta                                          327


<210>  38
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S5-SG VL

<400>  38
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgcgcg tatcacctgc       60

tccggtggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agactctgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcagcg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtccta                                          327


<210>  39
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SS01-13-S5 scFv

<400>  39
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgcgcg tatcacctgc       60

tccggtggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agactctgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcagcg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtcctaggt cagtcctcta gatcttccgg cggtggtgga      360

tcctctggtg gtggtggttc cgccgtgacg ttggacgagt ccgggggcgg cctccagacg      420

cccggaggag cgctccgcct ctcttgcaag gcctccgggt tcaccttcag cagctatcag      480

atgggctggg tgcgacaggc gcccggcaag gggctggaat gggtcagcgc gattaataag      540

agcggtagtg acacatcata cgggtcggcg gtgaagggcc gtgccaccat ctcgagggac      600

aacgggcaga gcacactgta cctgcagatg aacagcctca gggctgagga caccgctgtt      660

tacttctgcg ccaaaggttc tgctagttac ataactgctg ctaccatcga cgcatggggc      720

cacgggaccg aagtcatcgt ctcctcc                                          747


<210>  40
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S5-SG scFv

<400>  40
gccctgactc agccgtcctc ggtgtcagca aaccctgggg aaactgcgcg tatcacctgc       60

tccggtggtg ctagcagtgg ctatggttat ggctggtatc agcagaagcc tagcagtgcc      120

cctctcactg tgatctacaa agactctgaa agaccctcgg acatcccttc acgattctcc      180

ggttcctctt ccggctccac acacacatta accatcagcg gggtccaagc cgaggacgag      240

gctgtatatt tctgtgggaa tgatgactac agcagtgata gtggatatgt cggtgtattt      300

ggggccggga caaccctgac cgtcctaggt cagtcctcta gatcttccgg cggtggtgga      360

tcctctggtg gtggtggttc cgccgtgacg ttggacgagt ccgggggcgg cctccagacg      420

cccggaggag cgctccgcct ctcttgcaag gcctccgggt tcaccttcag cagctatcag      480

atgggctggg tgcgacaggc gcccggcaag gggctggaat gggtcagcgc gattaataag      540

ggcggtagtg acacatcata cgggtcggcg gtgaagggcc gtgccaccat ctcgagggac      600

aacgggcaga gcacactgta cctgcagatg aacagcctca gggctgagga caccgctgtt      660

tacttctgcg ccaaaggttc tgctagttac ataactgctg ctaccatcga cgcatggggc      720

cacgggaccg aagtcatcgt ctcctcc                                          747


