                         SEQUENCE LISTING

<110>  The University of Manchester
 
<120>  Methods for assessing and treating complement-related disorders

<130>  007450349

<150>  GB 1807611.7
<151>  2018-05-10

<150>  GB 1902790.3
<151>  2019-03-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  578
<212>  PRT
<213>  Homo sapiens FHR-4A (isoform 1) Uniprot: Q92496-1 Entry version 145 (28 Feb 2018), Sequence version 3 (22 Jan 2014)

<400>  1

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu 
            100                 105                 110         


Thr Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu 
            260                 265                 270         


Phe Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg 
        275                 280                 285             


Pro Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp 
    290                 295                 300                 


Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys 
305                 310                 315                 320 


Thr Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser 
                325                 330                 335     


Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser 
            340                 345                 350         


Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr 
        355                 360                 365             


Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn 
    370                 375                 380                 


Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val 
385                 390                 395                 400 


Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His 
                405                 410                 415     


Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly 
            420                 425                 430         


Asn Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe 
        435                 440                 445             


Pro Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile 
    450                 455                 460                 


Ser Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln 
465                 470                 475                 480 


Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser 
                485                 490                 495     


Asn Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys 
            500                 505                 510         


Ile His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile 
        515                 520                 525             


Gln Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp 
    530                 535                 540                 


Thr Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val 
545                 550                 555                 560 


Leu Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg 
                565                 570                 575     


Cys Glu 
        


<210>  2
<211>  577
<212>  PRT
<213>  Homo sapiens FHR-4A (isoform 2) Uniprot: Q92496-2 Deletion at position 20 Entry version 145 (28 Feb 2018), Sequence version 3 (22 Jan 2014)

<400>  2

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly 
            20                  25                  30          


Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly 
        35                  40                  45              


Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn 
                85                  90                  95      


Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr 
            100                 105                 110         


Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser 
        115                 120                 125             


Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys 
    130                 135                 140                 


Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser 
145                 150                 155                 160 


Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr 
                165                 170                 175     


Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys 
            180                 185                 190         


Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu 
        195                 200                 205             


Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe 
            260                 265                 270         


Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro 
        275                 280                 285             


Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln 
    290                 295                 300                 


Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser Lys 
                325                 330                 335     


Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile 
            340                 345                 350         


Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala 
        355                 360                 365             


Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly 
    370                 375                 380                 


Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe 
385                 390                 395                 400 


Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp 
                405                 410                 415     


Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn 
            420                 425                 430         


Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro 
        435                 440                 445             


Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser 
    450                 455                 460                 


Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser 
465                 470                 475                 480 


Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn 
                485                 490                 495     


Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile 
            500                 505                 510         


His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln 
        515                 520                 525             


Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr 
    530                 535                 540                 


Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu 
545                 550                 555                 560 


Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys 
                565                 570                 575     


Glu 
    


<210>  3
<211>  331
<212>  PRT
<213>  Homo sapiens FHR-4B Uniprot: Q92496-3 Deletion at positions 80-326 of FHR-4A Entry version 145 (28 Feb 2018), Sequence version 3 (22 Jan 2014)

<400>  3

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens FHR-4 signal peptide Positions 1-19 Uniprot: Q92496-1

<400>  4

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln 
            


<210>  5
<211>  558
<212>  PRT
<213>  Homo sapiens FHR-4A mature protein Positions 20-578 Uniprot: Q92496-1 Entry version 145 (28 Feb 2018), Sequence version 3 (22 Jan 2014)

<400>  5

Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly Leu Tyr 
1               5                   10                  15      


Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly Gln Ser 
            20                  25                  30          


Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr 
        35                  40                  45              


Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr Val Pro 
    50                  55                  60                  


Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn Gly Phe 
65                  70                  75                  80  


Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr Gln Tyr 
                85                  90                  95      


Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser Gly Ser 
            100                 105                 110         


Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys Ile Lys 
        115                 120                 125             


Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly 
    130                 135                 140                 


Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly 
145                 150                 155                 160 


Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys Gly Glu 
                165                 170                 175     


Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu Asn Cys 
            180                 185                 190         


Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe Pro Gln 
        195                 200                 205             


Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr 
    210                 215                 220                 


Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly Asp Trp 
225                 230                 235                 240 


Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe Pro Glu 
                245                 250                 255     


Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro Tyr Phe 
            260                 265                 270         


Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe 
        275                 280                 285             


Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp 
    290                 295                 300                 


Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Ser Lys Ser Asp Ile 
305                 310                 315                 320 


Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu 
                325                 330                 335     


Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp 
            340                 345                 350         


Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala 
        355                 360                 365             


Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser 
    370                 375                 380                 


Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp 
385                 390                 395                 400 


Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly 
                405                 410                 415     


Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr 
            420                 425                 430         


Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp 
        435                 440                 445             


Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu 
    450                 455                 460                 


Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr 
465                 470                 475                 480 


Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys 
                485                 490                 495     


Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly 
            500                 505                 510         


Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe 
        515                 520                 525             


Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln 
    530                 535                 540                 


Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
545                 550                 555             


<210>  6
<211>  312
<212>  PRT
<213>  Homo sapiens FHR-4B mature protein Positions 20-331 Uniprot: Q92496-3

<400>  6

Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly Leu Tyr 
1               5                   10                  15      


Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly Gln Ser 
            20                  25                  30          


Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr 
        35                  40                  45              


Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr Val Pro 
    50                  55                  60                  


Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe 
65                  70                  75                  80  


Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr 
                85                  90                  95      


Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser 
            100                 105                 110         


Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys 
        115                 120                 125             


Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly 
    130                 135                 140                 


Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly 
145                 150                 155                 160 


Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val Cys Gly Glu 
                165                 170                 175     


Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser Glu Lys Cys 
            180                 185                 190         


Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe Leu Leu 
        195                 200                 205             


Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr 
    210                 215                 220                 


Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly Glu Trp 
225                 230                 235                 240 


Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu Glu Asn 
                245                 250                 255     


Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp Ile Lys Tyr 
            260                 265                 270         


Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu Gly Tyr 
        275                 280                 285             


Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys Arg Glu Gly 
    290                 295                 300                 


Ile Val Glu Tyr Pro Arg Cys Glu 
305                 310         


<210>  7
<211>  1663
<212>  PRT
<213>  Homo sapiens C3 (UniProt: P01024; Entry version 221 (20 Dec 2017); Sequence version 2 (12 Dec 2006)) including signal peptide

<400>  7

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  8
<211>  645
<212>  PRT
<213>  Homo sapiens C3 beta chain (UniProt: P01024; Entry version 221 (20 Dec 2017); residues 23-667)

<400>  8

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu Ser 
1               5                   10                  15      


Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro 
            20                  25                  30          


Val Thr Val Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser 
        35                  40                  45              


Ser Glu Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val 
    50                  55                  60                  


Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg 
65                  70                  75                  80  


Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu 
                85                  90                  95      


Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr 
            100                 105                 110         


Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe 
        115                 120                 125             


Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val Asn 
    130                 135                 140                 


Ile Glu Asn Pro Glu Gly Ile Pro Val Lys Gln Asp Ser Leu Ser Ser 
145                 150                 155                 160 


Gln Asn Gln Leu Gly Val Leu Pro Leu Ser Trp Asp Ile Pro Glu Leu 
                165                 170                 175     


Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu Asn Ser Pro 
            180                 185                 190         


Gln Gln Val Phe Ser Thr Glu Phe Glu Val Lys Glu Tyr Val Leu Pro 
        195                 200                 205             


Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys Phe Tyr Tyr Ile Tyr 
    210                 215                 220                 


Asn Glu Lys Gly Leu Glu Val Thr Ile Thr Ala Arg Phe Leu Tyr Gly 
225                 230                 235                 240 


Lys Lys Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly 
                245                 250                 255     


Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu Lys Arg Ile Pro Ile Glu 
            260                 265                 270         


Asp Gly Ser Gly Glu Val Val Leu Ser Arg Lys Val Leu Leu Asp Gly 
        275                 280                 285             


Val Gln Asn Pro Arg Ala Glu Asp Leu Val Gly Lys Ser Leu Tyr Val 
    290                 295                 300                 


Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met Val Gln Ala Glu 
305                 310                 315                 320 


Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr 
                325                 330                 335     


Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val 
            340                 345                 350         


Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val Ala 
        355                 360                 365             


Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly Val 
    370                 375                 380                 


Ala Lys Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile 
385                 390                 395                 400 


Thr Val Arg Thr Lys Lys Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr 
                405                 410                 415     


Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn Asn 
            420                 425                 430         


Tyr Leu His Leu Ser Val Leu Arg Thr Glu Leu Arg Pro Gly Glu Thr 
        435                 440                 445             


Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu Ala Lys 
    450                 455                 460                 


Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu Leu Lys 
465                 470                 475                 480 


Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu Pro 
                485                 490                 495     


Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val Ala Tyr 
            500                 505                 510         


Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp Ser 
        515                 520                 525             


Val Trp Val Asp Val Lys Asp Ser Cys Val Gly Ser Leu Val Val Lys 
    530                 535                 540                 


Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr 
545                 550                 555                 560 


Leu Lys Ile Glu Gly Asp His Gly Ala Arg Val Val Leu Val Ala Val 
                565                 570                 575     


Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser 
            580                 585                 590         


Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro Gly 
        595                 600                 605             


Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr Phe 
    610                 615                 620                 


Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln Arg Ala Glu Leu Gln Cys 
625                 630                 635                 640 


Pro Gln Pro Ala Ala 
                645 


<210>  9
<211>  915
<212>  PRT
<213>  Homo sapiens C3 alpha' chain (UniProt: P01024; Entry version 221 (20 Dec 2017); Sequence version 2 (12 Dec 2006); residues 749-1663)

<400>  9

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly 
        195                 200                 205             


Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro 
    210                 215                 220                 


Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala 
225                 230                 235                 240 


Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile 
                245                 250                 255     


Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            260                 265                 270         


Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys 
        275                 280                 285             


Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly 
    290                 295                 300                 


Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala 
305                 310                 315                 320 


Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
                325                 330                 335     


Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
            340                 345                 350         


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
        355                 360                 365             


Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly 
    370                 375                 380                 


Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu 
385                 390                 395                 400 


Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser 
                405                 410                 415     


Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr 
            420                 425                 430         


Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
        435                 440                 445             


Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr 
    450                 455                 460                 


Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr 
465                 470                 475                 480 


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys 
                485                 490                 495     


Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
            500                 505                 510         


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
        515                 520                 525             


Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu 
    530                 535                 540                 


Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile Thr 
545                 550                 555                 560 


His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu Glu Thr 
                565                 570                 575     


Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly Gln Gly 
            580                 585                 590         


Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys Asp Gln Leu 
        595                 600                 605             


Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala Pro Glu 
    610                 615                 620                 


Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile 
625                 630                 635                 640 


Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp 
                645                 650                 655     


Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln 
            660                 665                 670         


Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys 
        675                 680                 685             


Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser 
    690                 695                 700                 


His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn 
705                 710                 715                 720 


Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn 
                725                 730                 735     


Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly 
            740                 745                 750         


Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu Glu 
        755                 760                 765             


Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg 
    770                 775                 780                 


Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg 
785                 790                 795                 800 


Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala 
                805                 810                 815     


Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln 
            820                 825                 830         


Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu 
        835                 840                 845             


Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp 
    850                 855                 860                 


Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp Thr Trp Val 
865                 870                 875                 880 


Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu Glu Asn Gln Lys 
                885                 890                 895     


Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly 
            900                 905                 910         


Cys Pro Asn 
        915 


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #1 Position: 46 siRNA target

<400>  10
gaatcacact tggtaactaa t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #1 Position: 46 siRNA scrambled

<400>  11
gccaagaatg tacctattat a                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #2 Position: 835 siRNA target

<400>  12
ggtcaagagt cgagtaccag t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #2 Position: 835 siRNA scrambled (negative 
       control)

<400>  13
gggtgaatcc cgcatggtaa a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #3 Position: 1401 siRNA target

<400>  14
gaatgctacg atggatatga a                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #3 Position: 1401 siRNA scrambled (negative 
       control)

<400>  15
gataaggtga gccattagat a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #4 Position: 1658 siRNA target

<400>  16
ggaaccacca agatgcatac a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #4 Position: 1658 siRNA scrambled (negative 
       control)

<400>  17
gcactcaaga agacgatacc a                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #5 Position: 1794 siRNA target

<400>  18
ggatataatg cgaatacatc a                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #5 Position: 1794 siRNA scrambled (negative 
       control)

<400>  19
gcataagaat atacgttcag a                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #6 Position: 2154 siRNA target

<400>  20
gcatattgta cagtatacct a                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct FHR4 #6 Position: 2154 siRNA scrambled (negative 
       control)

<400>  21
gttgctatcg tctataaaca a                                                 21


