                         SEQUENCE LISTING

<110>  Roche Innovation Center Copenhagen A/S
 
<120>  QUALITY CONTROL OF LNA OLIGONUCLEOTIDE THERAPEUTICS USING 
       MASSIVELY PARALLEL SEQUENCING

<130>  P34796-WO

<150>  EP18171022.9
<151>  2018-05-07

<150>  EP18171024.5
<151>  2018-05-07

<150>  EP18171029.4
<151>  2018-05-07

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  1

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  2
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  2
gcgtaactag accataagcc gatagcttga ac                                     32


<210>  3
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  3
gcgtaactag accataagcc gatagcttga ac                                     32


<210>  4
<211>  67
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  4
cggaccagca agcttagaga tcacggtatc cagattcgct catagtacac aactgcctcc       60

ggttcaa                                                                 67


<210>  5
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  5
gcagttgtgt actatgagcg a                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  6
gcgtaactag accataagcc                                                   20


<210>  7
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  7
ctacctgagt ggcatcct                                                     18


<210>  8
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  8
ctacctgagt ggcatcct                                                     18


<210>  9
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  9
cagaaaatac ctacctga                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  10
gcttttaacc agagtggc                                                     18


<210>  11
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  11
gcgtaactag accataagcc gatagcttga ac                                     32


<210>  12
<211>  79
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(79)
<223>  n is a, c, g, or t

<400>  12
ccgcaattgg cgtgatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcggnnnnn                                                    79


<210>  13
<211>  79
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(79)
<223>  n is a, c, g, or t

<400>  13
ccgcaattgg acatcgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcggnnnnn                                                    79


<210>  14
<211>  79
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(79)
<223>  n is a, c, g, or t

<400>  14
ccgcaattgg cactgtnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcggnnnnn                                                    79


<210>  15
<211>  79
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(79)
<223>  n is a, c, g, or t

<400>  15
ccgcaattgg attggcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcggnnnnn                                                    79


<210>  16
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  16
ctatcacgcg acatgcgg                                                     18


<210>  17
<211>  52
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds


<220>
<221>  misc_feature
<222>  (47)..(52)
<223>  n is a, c, g, or t

<400>  17
ccgcaagatc ggaagagcgg ttcagcagga atgcatatgc ttgcggnnnn nn               52


<210>  18
<211>  58
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  18
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  19
<211>  62
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  19
caagcagaag acggcatacg agatcggtct cggcattcct gctgaaccgc tcttccgatc       60

tt                                                                      62


<210>  20
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  20
cagcattggt attca                                                        15


<210>  21
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide probes or primers or compounds

<400>  21
cagcttttaa ccagagtg                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  22
gtctagaatg cgcacgtc                                                     18


<210>  23
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  23
tgtctagagc ctgcacgtc                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  24
tgtctagcat gtgcacgtc                                                    19


<210>  25
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  25
tgtctagcgt acgcacgtc                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  26
tgtctaggaa tggcacgtc                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  27
tgtctaggta atgcacgtc                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  28
tgtctaggcg tggcacgtc                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  29
tgtctagacc tagcacgtc                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  30
tgtctagcaa ctgcacgtc                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  31
tgtctagatt cagcacgtc                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  32
tgtctaggtc ctgcacgtc                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  33
tgtctagact tggcacgtc                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  34
tgtctagacg ctgcacgtc                                                    19


<210>  35
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  35
ccgcaagtgg cgtgatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  36
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  36
ccgcaagtgg acatcgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  37
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  37
ccgcaagtgg gcctaannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  38
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  38
ccgcaagtgg tggtcannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  39
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  39
ccgcaagtgg cactgtnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  40
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  40
ccgcaagtgg attggcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  41
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  41
ccctatgacg cgacatgcgg a                                                 21


<210>  42
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  42
ccgcaaggag atcggaagag cacacgtctg aactccatat gcttgcggcg tctac            55


<210>  43
<211>  58
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  43
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  44
<211>  61
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  44
caagcagaag acggcatacg agatcggtct cggcattcct gctgaaccgc tcttccgatc       60

t                                                                       61


<210>  45
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  45
tgtctagtgc cagcacgtc                                                    19


<210>  46
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  46
starycgtct acatccaccc acgtc                                             25


<210>  47
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  47
starycgtct acgcttgtcc acgtc                                             25


<210>  48
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  48
chstrcgtct acggacttcc acgtc                                             25


<210>  49
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  49
chstrcgtct acaagtcccc acgtc                                             25


<210>  50
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  50
bamncgtcta ctctctacca cgtc                                              24


<210>  51
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  51
bamncgtcta cctctcgcca cgtc                                              24


<210>  52
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  52
bachcgtcta cagttcacca cgtc                                              24


<210>  53
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  53
bachcgtcta cgacctgcca cgtc                                              24


<210>  54
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  54
bacdcgtcta ccaagctcca cgtc                                              24


<210>  55
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  55
bacdcgtcta ctggatccca cgtc                                              24


<210>  56
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  56
cgtctaccca agtccacgtc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  57
cgtctacttg gacccacgtc                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  58
cgtctacggc ttaccacgtc                                                   20


<210>  59
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  59
tchrcgtcta cccgcggcca cgtc                                              24


<210>  60
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  60
tchrcgtcta cttataacca cgtc                                              24


<210>  61
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  61
ccgcaagtgg cgtgatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  62
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  62
ccgcaagtgg acatcgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  63
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  63
ccgcaagtgg gcctaannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  64
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  64
ccgcaagtgg tggtcannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  65
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  65
ccgcaagtgg cactgtnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  66
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  66
ccgcaagtgg attggcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  67
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  67
ccgcaagtgg gatctgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  68
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  68
ccgcaagtgg tcaagtnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  69
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  69
ccgcaagtgg agcgctnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  70
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  70
ccgcaagtgg gatatcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  71
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  71
ccgcaagtgg cgcagannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  72
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  72
ccgcaagtgg tatgagnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  73
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  73
ccgcaagtgg aggtgcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  74
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  74
ccgcaagtgg gaacatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  75
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  75
ccgcaagtgg acatagnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  76
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  76
ccgcaagtgg gtgcgannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  77
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  77
ccgcaagtgg ccaacannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  78
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  78
ccgcaagtgg ttggtgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  79
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  79
ccgcaagtgg cgcggtnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  80
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  80
ccgcaagtgg tataacnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  81
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  81
ccgcaagtgg aaggatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  82
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  82
ccgcaagtgg gcaagcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  83
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  83
ccgcaagtgg tcgtgannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  84
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  84
ccgcaagtgg ctacagnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  85
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  85
ccgcaagtgg atattcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  86
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  86
ccgcaagtgg gcgcctnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  87
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  87
ccgcaagtgg actctannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  88
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  88
ccgcaagtgg gtctcgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  89
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  89
ccgcaagtgg aagacgnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  90
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  90
ccgcaagtgg cgagtannnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  91
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  91
ccgcaagtgg aaccgcnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  92
<211>  80
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  92
ccgcaagtgc ggttatnnnn agatcggaag agcgtcgtgt agtccgcatg tcgcgtgata       60

gggatatctt gcgggacgtg                                                   80


<210>  93
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  93
ccgcaaggag atcggaagag cacacgtctg aactccatat gcttgcggcg tctac            55


<210>  94
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide nucleobase sequence

<400>  94
caagcagaag acggcatacg agatcggtct cgggagttca gacgtgtgct cttccgatct       60


