                         SEQUENCE LISTING

<110>  Centro de Inmunologa Molecular
 
<120>  Protenas de fusin compuestas por una mutena de IL2 e 
       interfern tipo 1

<130>  592018CU00

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  1

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Ala Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  3

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  4
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  4

Cys Asp Leu Pro His Thr Tyr Asn Leu Gly Asn Lys Arg Ala Leu Thr 
1               5                   10                  15      


Val Leu Glu Glu Met Arg Arg Leu Pro Pro Leu Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Lys Asp Phe Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Leu Val Leu Arg Asp Leu Thr Gln Gln Ile 
    50                  55                  60                  


Leu Asn Leu Phe Thr Ser Lys Asp Leu Ser Ala Thr Trp Asn Ala Thr 
65                  70                  75                  80  


Leu Leu Asp Ser Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Lys Ala Cys Val Met Gln Glu Pro Pro Leu Thr Gln Glu Asp Ser Leu 
            100                 105                 110         


Leu Ala Val Arg Thr Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Lys 
        115                 120                 125             


Lys Lys His Ser Leu Cys Ala Trp Glu Val Ile Arg Ala Glu Val Trp 
    130                 135                 140                 


Arg Ala Leu Ser Ser Ser Thr Asn Leu Leu Ala Arg Leu Ser Glu Glu 
145                 150                 155                 160 


Lys Glu 
        


<210>  5
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  5

Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser 
                245     


<210>  6
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  6

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro 
                165                 170                 175     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            180                 185                 190         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    210                 215                 220                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
225                 230                 235                 240 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                245                 250                 255     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            260                 265                 270         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        275                 280                 285             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    290                 295                 300                 


Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
305                 310                 315                 320 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                325                 330                 335     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        355                 360                 365             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    370                 375                 380                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
                405                 410                 415     


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
            420                 425                 430         


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
        435                 440                 445             


Ala Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu Leu 
    450                 455                 460                 


Lys His Leu Gln Cys Leu Glu Glu Ala Leu Lys Pro Leu Glu Glu Val 
465                 470                 475                 480 


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
                485                 490                 495     


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
            500                 505                 510         


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
        515                 520                 525             


Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
    530                 535                 540                 


<210>  7
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  7

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro 
                165                 170                 175     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            180                 185                 190         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    210                 215                 220                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
225                 230                 235                 240 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                245                 250                 255     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            260                 265                 270         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        275                 280                 285             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    290                 295                 300                 


Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
305                 310                 315                 320 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                325                 330                 335     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        355                 360                 365             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    370                 375                 380                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
                405                 410                 415     


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
            420                 425                 430         


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
        435                 440                 445             


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
    450                 455                 460                 


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
465                 470                 475                 480 


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe Asp Pro Arg Asp Val 
                485                 490                 495     


Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu Lys Gly Ser Glu Thr 
            500                 505                 510         


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
        515                 520                 525             


Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    530                 535                 540                 


<210>  8
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  8

Cys Asp Leu Pro His Thr Tyr Asn Leu Gly Asn Lys Arg Ala Leu Thr 
1               5                   10                  15      


Val Leu Glu Glu Met Arg Arg Leu Pro Pro Leu Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Lys Asp Phe Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Leu Val Leu Arg Asp Leu Thr Gln Gln Ile 
    50                  55                  60                  


Leu Asn Leu Phe Thr Ser Lys Asp Leu Ser Ala Thr Trp Asn Ala Thr 
65                  70                  75                  80  


Leu Leu Asp Ser Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Lys Ala Cys Val Met Gln Glu Pro Pro Leu Thr Gln Glu Asp Ser Leu 
            100                 105                 110         


Leu Ala Val Arg Thr Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Lys 
        115                 120                 125             


Lys Lys His Ser Leu Cys Ala Trp Glu Val Ile Arg Ala Glu Val Trp 
    130                 135                 140                 


Arg Ala Leu Ser Ser Ser Thr Asn Leu Leu Ala Arg Leu Ser Glu Glu 
145                 150                 155                 160 


Lys Glu Ala Ala Ala Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
                165                 170                 175     


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
            180                 185                 190         


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala Ile Ser 
        195                 200                 205             


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
    210                 215                 220                 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
225                 230                 235                 240 


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
        275                 280                 285             


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
    290                 295                 300                 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
305                 310                 315                 320 


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
                325                 330                 335     


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
            340                 345                 350         


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
        355                 360                 365             


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
    370                 375                 380                 


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                405                 410                 415     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            420                 425                 430         


Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Ala 
        435                 440                 445             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    450                 455                 460                 


Ala Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
465                 470                 475                 480 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                485                 490                 495     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            500                 505                 510         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        515                 520                 525             


Gln Ser Ile Ile Ser Thr Leu Thr 
    530                 535     


<210>  9
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  9

Cys Asp Leu Pro His Thr Tyr Asn Leu Gly Asn Lys Arg Ala Leu Thr 
1               5                   10                  15      


Val Leu Glu Glu Met Arg Arg Leu Pro Pro Leu Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Lys Asp Phe Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Leu Val Leu Arg Asp Leu Thr Gln Gln Ile 
    50                  55                  60                  


Leu Asn Leu Phe Thr Ser Lys Asp Leu Ser Ala Thr Trp Asn Ala Thr 
65                  70                  75                  80  


Leu Leu Asp Ser Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Lys Ala Cys Val Met Gln Glu Pro Pro Leu Thr Gln Glu Asp Ser Leu 
            100                 105                 110         


Leu Ala Val Arg Thr Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Lys 
        115                 120                 125             


Lys Lys His Ser Leu Cys Ala Trp Glu Val Ile Arg Ala Glu Val Trp 
    130                 135                 140                 


Arg Ala Leu Ser Ser Ser Thr Asn Leu Leu Ala Arg Leu Ser Glu Glu 
145                 150                 155                 160 


Lys Glu Ala Ala Ala Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
                165                 170                 175     


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
            180                 185                 190         


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala Ile Ser 
        195                 200                 205             


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
    210                 215                 220                 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
225                 230                 235                 240 


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
        275                 280                 285             


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
    290                 295                 300                 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
305                 310                 315                 320 


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
                325                 330                 335     


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
            340                 345                 350         


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
        355                 360                 365             


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
    370                 375                 380                 


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                405                 410                 415     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            420                 425                 430         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        435                 440                 445             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    450                 455                 460                 


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
465                 470                 475                 480 


Phe His Phe Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val 
                485                 490                 495     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            500                 505                 510         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
        515                 520                 525             


Gln Ser Ile Ile Ser Thr Leu Thr 
    530                 535     


<210>  10
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  10
tgcgatctgc cccacaccta caacctgggc aacaagagag ccctgaccgt gctggaggag       60

atgaggagac tgcctcctct gtcctgcctg aaggacagga aggacttcgg cttccccctg      120

gagaaggtgg acaaccagca gatccagaag gcccaggcta tcctggtgct gagagacctg      180

acacagcaga tcctgaacct gttcacctcc aaggacctgt ctgccacctg gaatgccacc      240

ctgctggact ccttctgcaa cgacctgcac cagcagctga acgacctgaa ggcctgcgtg      300

atgcaggagc ctcctctgac ccaggaggat tctctgctgg ctgtgcggac ctacttccac      360

cggatcaccg tgtacctgcg gaagaagaag cactctctgt gcgcctggga ggtgatcaga      420

gccgaagtgt ggagagccct gtcctcctct accaacctgc tggccaggct gtctgaggag      480

aaggaggcgg ccgcttctgg ttgtaagcct tgcatatgta cagtcccaga agtatcatct      540

gtcttcatct tccccccaaa gcccaaggat gtgctcacca ttactctgac tcctaaggtc      600

acgtgtgttg tggtagccat cagcaaggat gatcccgagg tccagttcag ctggtttgta      660

gatgatgtgg aggtgcacac agctcagacg caaccccggg aggagcagtt caacagcact      720

ttccgctcag tcagtgaact tcccatcatg caccaggact ggctcaatgg caaggagttc      780

aaatgcaggg tcaacagtgc agctttccct gcccccatcg agaaaaccat ctccaaaacc      840

aaaggcagac cgaaggctcc acaggtgtac accattccac ctcccaagga gcagatggcc      900

aaggataaag tcagtctgac ctgcatgata acagacttct tccctgaaga cattactgtg      960

gagtggcagt ggaatgggca gccagcggag aactacaaga acactcagcc catcatggac     1020

acagatggct cttacttcgt ctacagcaag ctcaatgtgc agaagagcaa ctgggaggca     1080

ggaaatactt tcacctgctc tgtgttacat gagggcctgc acaaccacca tactgagaag     1140

agcctctccc actctcctgg taaagccccc acctccagca gcaccaagaa aactcagctc     1200

cagctcgaac atctgctgct ggatctgcag atgatcctga acggcatcaa caactacaag     1260

aaccccaagc tgaccgccat gctgacagcc aagttcgcca tgcccaagaa ggccaccgag     1320

ctgaagcatc tgcagtgcct ggaagaggcc ctgaagcctc tggaagaggt gctgaacctg     1380

gcccagtcca agaacttcca cctgaggccc agggacctga tcagcaacat caacgtgatc     1440

gtgctggaac tgaagggcag cgagacaacc ttcatgtgcg agtacgccga cgagacagca     1500

acaatcgtgg agtttctgaa ccggtggatc accttcagcc agagcatcat cagcaccctg     1560

acc                                                                   1563


<210>  11
<211>  1632
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  11
tgcgatctgc cgcagaccca tagcctgggc agccgccgca ccctgatgct gctggcgcag       60

atgcgcaaaa ttagcctgtt tagctgcctg aaagatcgcc atgattttgg ctttccgcag      120

gaagaatttg gcaaccagtt tcagaaagcg gaaaccattc cggtgctgca tgaaatgatt      180

cagcagattt ttaacctgtt tagcaccaaa gatagcagcg cggcgtggga tgaaaccctg      240

ctggataaat tttataccga actgtatcag cagctgaacg atctggaagc gtgcgtgatt      300

cagggcgtgg gcgtgaccga aaccccgctg atgaaagaag atagcattct ggcggtgcgc      360

aaatattttc agcgcattac cctgtatctg aaagaaaaaa aatatagccc gtgcgcgtgg      420

gaagtggtgc gcgcggaaat tatgcgcagc tttagcctga gcaccaacct gcaggaaagc      480

ctgcgcagca aagaagcggc cgctagcgac aaaactcaca catgcccacc gtgcccagca      540

cctgaagccg cggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      600

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      660

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      720

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      780

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      840

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      900

cccccatccc gggaggaggt gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      960

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1020

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1080

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1140

ctgcacaacc actacacgca gaagtcgctc agcctgtccc cgggtaaagg tggaggcggt     1200

tcaggcggag gtggttctgg cggtggcgga tcggcgccga ccagcagcag caccaaaaaa     1260

acccagctgc agctggaaca tctgctgctg gatctgcaga tgattctgaa cggcattaac     1320

aactataaaa acccgaaact gacccgcatg ctgaccttta aattttatat gccgaaaaaa     1380

gcgaccgaac tgaaacatct gcagtgcctg gaagaagaac tgaaaccgct ggaagaagtg     1440

ctgaacctgg cgcagagcaa aaactttcat tttgatccgc gcgatgtggt gagcaacatt     1500

aacgtgtttg tgctggaact gaaaggcagc gaaaccacct ttatgtgcga atatgcggat     1560

gaaaccgcga ccattgtgga atttctgaac cgctggatta ccttttgcca gagcattatt     1620

agcaccctga cc                                                         1632


<210>  12
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  by DNA recombinant technology

<400>  12

Ala Ala Ala Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
1               5                   10                  15      


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
            20                  25                  30          


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala Ile Ser Lys Asp 
        35                  40                  45              


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
    50                  55                  60                  


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
65                  70                  75                  80  


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
        115                 120                 125             


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
    130                 135                 140                 


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
145                 150                 155                 160 


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
                165                 170                 175     


Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
            180                 185                 190         


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
        195                 200                 205             


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
    210                 215                 220                 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser 
    


