                         SEQUENCE LISTING

<110>  йũҵѧ
 
<120>  CRISPR/CasЧӦ׼ϵͳ

<130>  IEC180068PCT

<150>  CN 201810426666.1
<151>  2018-05-07

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  882
<212>  PRT
<213>  ˹

<220>
<223>  Cas12g.1İ

<400>  1

Met Leu Tyr Thr Met Asn Val Lys Thr Ile Lys Leu Lys Val Asp Ala 
1               5                   10                  15      


Thr Lys Glu Val Glu Ser Arg Leu Thr Lys Met Leu Leu Val His Asn 
            20                  25                  30          


Asn Ile Gly Arg Glu Ile Ile Asn Phe Leu Ile Leu Cys Ser Gly Asn 
        35                  40                  45              


Asp Asn Ile Arg Lys Thr Lys Phe Asp Glu Phe Gly Asn Ser Tyr Asp 
    50                  55                  60                  


Glu Phe Cys Asn Leu Lys Leu Asp Gln Phe Asn Leu Tyr Asp Arg Leu 
65                  70                  75                  80  


Thr Glu Ile His Asp Glu Val Thr Leu Glu Asp Phe Gln Lys Thr Leu 
                85                  90                  95      


Asn Asp Ile Tyr Asp Leu Val Leu Asn Ser Lys Ser Phe Ser Asn Val 
            100                 105                 110         


Ser Ser Thr Ile Phe Asn Lys Asn Lys Lys Val Asn Phe Asp Glu Thr 
        115                 120                 125             


Lys Lys Gly Asp Leu Ser Arg Lys Cys Leu Met Asn Ala Arg Asp Trp 
    130                 135                 140                 


Gly Val Leu Pro Leu Ile Ser Val Asp Asp Asp Ile Val Thr Cys Gly 
145                 150                 155                 160 


Thr Leu Lys Gly Ile Leu Ser Glu Cys Gln Ser Arg Ile Leu Ser Trp 
                165                 170                 175     


Asn Glu Cys Asn Leu Ser Thr Lys Glu Thr Tyr Ser Glu Lys Lys Ser 
            180                 185                 190         


Glu Tyr Gln Ser Ile Leu Asp Asp Ser Met Thr Lys Asp Ala Asp Val 
        195                 200                 205             


Thr Thr Ala Met Ile Gln Phe Met Asp Asp Val Ser Asn Val Tyr Gly 
    210                 215                 220                 


Ser Asn Asn Glu Asn Gln Leu Lys Trp Phe Asn Asn Arg Phe Leu Thr 
225                 230                 235                 240 


Tyr Val Arg Asn Lys Ile Arg Pro Phe Leu Leu Thr Asn Ser Pro Ile 
                245                 250                 255     


Asp Asn Phe Glu Gln Ser Asp Thr Ser Tyr Asn Cys Ser Ile Glu Ile 
            260                 265                 270         


Val Arg Ile Leu Ser Lys Tyr Glu Ile Leu Trp Lys Asp Glu Val Ser 
        275                 280                 285             


Val Asn Arg Tyr Lys Lys Thr Cys Asp Asp Gly Ile Asn Ile Glu Lys 
    290                 295                 300                 


Tyr Arg Tyr Leu Val His Ala Lys Ser Asp Phe Leu Arg Tyr Lys Glu 
305                 310                 315                 320 


Thr Ala Ser Phe Lys Glu Ile His Ala Val Lys Ser Pro Ile Ser Leu 
                325                 330                 335     


Cys Phe Gly Asn Asn Tyr Gln Pro Phe Ser Leu Ser Asp Val Gly Asp 
            340                 345                 350         


Arg His Asn Ile Asn Phe Gly Tyr Lys Phe Gly Lys Leu Gly Lys Gln 
        355                 360                 365             


Arg Lys Glu Cys Ser Phe Asn Leu Asn Tyr Arg Arg Lys Lys Val Lys 
    370                 375                 380                 


Tyr Ala Asn Thr Pro Val Arg Ser Asp Glu Asn Lys Cys Tyr Leu Asp 
385                 390                 395                 400 


Asn Leu Glu Ile Glu Asp Ala Lys Asn Gly Ser Tyr Lys Leu Ser Tyr 
                405                 410                 415     


Met Val Asn Lys Lys Tyr Lys Arg Glu Ser Phe Ile Lys Glu Pro Lys 
            420                 425                 430         


Met Lys Met Tyr Asn Gly Lys Leu Tyr Met Tyr Phe Pro Met Ser Asn 
        435                 440                 445             


Glu Phe Glu Glu Asp Arg Asp Ser Phe Ala Leu Leu Thr Tyr Phe Ser 
    450                 455                 460                 


Arg Ser Ser Asn Ser Lys Ser Gln Ile Asp Glu Ala Ser Asn Ile Leu 
465                 470                 475                 480 


Gln Asn Arg Lys Ile Arg Val Cys Gly Val Asp Leu Gly Ile Asn Pro 
                485                 490                 495     


Thr Phe Ala Leu Ser Val Leu Glu Tyr Ser Asp Asn Lys Ile Thr Asp 
            500                 505                 510         


Thr Asn Ile Gly Met Lys His Glu Gly Ser Tyr Asn Asn Phe Ser Glu 
        515                 520                 525             


Ile Arg Lys Gln Ile Asn Asp Val Thr Asp Met Ile Ser Tyr Leu Lys 
    530                 535                 540                 


Ser Lys Tyr Asp Asn Cys Glu Lys Asp Tyr Ser Ser Lys Ile Asp Asp 
545                 550                 555                 560 


His Ile Lys Ser Arg Leu Asn Glu Glu Ile Ser Asn Phe Cys Asp Leu 
                565                 570                 575     


Val Ser Tyr Lys Arg Asn Lys Asn Thr Ile Ile Arg Lys Glu Ile Lys 
            580                 585                 590         


Asn Val Glu Lys Glu Ile Asn Lys Ile Lys Asn Cys Arg Arg His Thr 
        595                 600                 605             


Leu Lys Lys Asp Leu Thr Glu Asn Phe Gly Trp Val Ser Ala Leu Asn 
    610                 615                 620                 


Glu Phe Ile Ser Leu Lys His Ser Phe Asn Asp Met Gly Glu Ser Phe 
625                 630                 635                 640 


Asp Ser Lys Thr Asn Pro Ser Tyr Ser Tyr Phe Glu Lys Trp Lys Arg 
                645                 650                 655     


Tyr Ile Asp Asn Ile Lys Asp Asp Ser Leu Lys Thr Val Ser Arg Glu 
            660                 665                 670         


Ile Leu Asn Phe Cys Ile Glu Asn Ser Val Asp Phe Ile Ala Leu Glu 
        675                 680                 685             


Asp Leu Gln Thr Phe Ala Pro Ser Asp Asp Arg Thr Lys Ser His Asn 
    690                 695                 700                 


Lys Leu Thr Gln Leu Trp Cys Phe Gly Lys Leu Lys Lys Cys Leu Glu 
705                 710                 715                 720 


Asp Ile Ala Ser Met Tyr Gly Ile His Val Tyr Ser Ser Thr Asp Pro 
                725                 730                 735     


Arg Asn Thr Ser Asp Thr His Phe Glu Ser Lys Asn Phe Gly Tyr Arg 
            740                 745                 750         


Asp Glu Ser Asn Lys His Asn Leu Trp Val Asn Val Asp Gly Glu Tyr 
        755                 760                 765             


Thr Val Val Asp Ser Asp Ile Asn Ala Ser Lys Asn Ile Ala Asn Arg 
    770                 775                 780                 


Phe Leu Thr His His Lys Asp Leu Lys Gln Leu Pro Met Ile Gly Asp 
785                 790                 795                 800 


Gly Thr Leu Phe Lys Ile Asp Ser Ser Ser Lys Arg Asn Lys Ser Phe 
                805                 810                 815     


Ala Val Lys Leu Asn Ile His Lys Asn Val Tyr Glu Leu Ile Asp Gly 
            820                 825                 830         


Glu Phe Val Lys Ser Asn Lys Lys Pro Asn Gly Thr Ser Arg Lys Gln 
        835                 840                 845             


Thr Ala Tyr Ile His Gly Asp Met Phe Ile Asp Ser Ile Ser His Lys 
    850                 855                 860                 


Asn Lys Lys Met Phe Leu Arg Glu Asn Leu Ile Arg Asn Gly Phe Ile 
865                 870                 875                 880 


Ser Lys 
        


<210>  2
<211>  935
<212>  PRT
<213>  ˹

<220>
<223>  Cas12g.2İ

<400>  2

Met Asn Lys Thr Asp Thr Gln Asn Asn Glu Gln Ile Asn Lys Pro Thr 
1               5                   10                  15      


Gln Leu Leu Asn Asn Lys Asp Ile Glu Leu Thr Val Lys Thr Val Lys 
            20                  25                  30          


Ser Ala Thr Val Lys Val Asp Asn Asn Ser Lys Lys Glu Leu Phe Gly 
        35                  40                  45              


Leu Phe Asn Tyr Phe Thr Ser Val Ala Ser Gly Ile Lys Asp Lys Val 
    50                  55                  60                  


Tyr Asn Leu Gln Ser Asp Glu Lys Thr Ala Pro Ile Phe Asn Asp Tyr 
65                  70                  75                  80  


Val Lys Gln Pro Gln Arg Gly Arg Ser Ala Ala Thr Thr Leu Phe Thr 
                85                  90                  95      


Lys Leu Asp Ala Glu Lys Thr Tyr Thr Ser Gln His Ser Phe Pro Gly 
            100                 105                 110         


Lys Trp Arg Asp Ser Gly Ile Phe Pro Leu Tyr Asn Lys Glu Ser Glu 
        115                 120                 125             


Lys Tyr Asp Leu Ser Thr His Gly Tyr His Tyr Ser Ala Asn Ala Glu 
    130                 135                 140                 


Ile His Thr Gln Leu Asp Ser His Asp Glu Cys Asn Lys Glu Cys Glu 
145                 150                 155                 160 


Lys Glu Tyr Ala Ala Leu Arg Asp Glu Val Asn Asn Tyr Lys Tyr Glu 
                165                 170                 175     


Phe Thr Leu Gln Phe Lys Ala Glu Asn Ala Glu Lys Phe Tyr Asn Phe 
            180                 185                 190         


Val Glu Lys Leu Thr Leu Met Gly Trp Arg Tyr Asp Ala Thr Phe Arg 
        195                 200                 205             


Ser Phe Phe Glu Leu His Met His Pro Lys Leu Lys Thr Gly Glu Thr 
    210                 215                 220                 


Thr Tyr Arg Ala Thr Tyr Lys Leu Pro Ser Gly Lys Ser Lys Arg Tyr 
225                 230                 235                 240 


Ser Phe Phe Arg Asp Asp Ile Ala Asp Glu Ile Ala Lys Asn Pro Glu 
                245                 250                 255     


Phe Trp Pro Met Leu Glu Ser Ser Asn Ala Ile Ser Trp Ile Asn Ser 
            260                 265                 270         


Asn Asn Leu Leu Ser Arg Lys Lys Asp Lys Ala Asn Tyr Ser Ser Thr 
        275                 280                 285             


Ser Leu Ile Lys Ser Gln Ile Arg Leu Tyr Leu Gly Asn Asn Gly Val 
    290                 295                 300                 


Pro Phe Thr Ala Arg Glu His Asp Gly Arg Ile Tyr Phe Ser Phe Arg 
305                 310                 315                 320 


Leu Pro Ala Ile Asn Gly Glu Lys Gly Arg Met Val Glu Ile Pro Cys 
                325                 330                 335     


Ser Tyr Lys Lys Val Phe Asn Gly Lys Ala Arg Lys Ser Cys Tyr Leu 
            340                 345                 350         


Gly Gly Leu Thr Ile Glu Lys Thr Asp Ala Gly Lys His Ile Phe Lys 
        355                 360                 365             


Tyr Ser Val Asn Asn Lys Lys Pro Gln Val Ala Glu Leu Asn Glu Cys 
    370                 375                 380                 


Phe Leu Arg Leu Val Val Arg Asn Arg Glu Tyr Phe Asn Asn Val Val 
385                 390                 395                 400 


Ala Gly Lys Ile Thr Asp Ile Asn Thr Asp His Phe Asp Phe Tyr Val 
                405                 410                 415     


Asp Leu Pro Leu Asn Val Lys Glu Asp Pro Ile His Asp Leu Ser Ser 
            420                 425                 430         


Thr Glu Val Phe Gly Lys Asn Gly Leu Arg Ser Tyr Tyr Ser Ser Ala 
        435                 440                 445             


Tyr Pro Glu Ile Lys Asn Leu Gly Ser Gln Ile Glu Thr Gly Lys Asn 
    450                 455                 460                 


Leu Thr Cys Pro Ile Thr Lys Thr His Asn Ile Met Gly Ile Asp Leu 
465                 470                 475                 480 


Gly Gln Arg Asn Pro Phe Ala Tyr Cys Ile Lys Asp Asn Thr Gly Lys 
                485                 490                 495     


Leu Ile Ala Gln Gly His Met Asp Gly Ser Lys Asn Glu Thr Tyr Lys 
            500                 505                 510         


Lys Tyr Ile Asn Phe Gly Lys Glu Ser Thr Ser Val Ser His Leu Ile 
        515                 520                 525             


Lys Glu Thr Arg Ser Tyr Leu His Gly Asp Pro Glu Ala Ile Ser Lys 
    530                 535                 540                 


Glu Leu Tyr Asn Glu Val Ala Gly Phe Cys Asn Asn Pro Val Ser Tyr 
545                 550                 555                 560 


Glu Glu Tyr Leu Lys Tyr Leu Asp Ser Lys Lys Phe Leu Ile Asn Lys 
                565                 570                 575     


Glu Asp Leu Ser Lys Asn Ala Met His Leu Leu Arg Gln Lys Asp His 
            580                 585                 590         


Asn Trp Ile Gly Arg Asp Trp Leu Trp Tyr Ile Ser Lys Gln Tyr Lys 
        595                 600                 605             


Lys His Asn Glu Asn Arg Met Gln Asp Ala Asp Trp Arg Gln Thr Leu 
    610                 615                 620                 


Tyr Trp Ile Asp Ser Leu Tyr Arg Tyr Ile Asp Val Met Lys Ser Phe 
625                 630                 635                 640 


His Asn Phe Gly Ser Phe Tyr Asp Lys Asn Leu Lys Lys Lys Val Asn 
                645                 650                 655     


Gly Thr Val Val Gly Phe Cys Lys Thr Val His Asp Gln Ile Asn Asn 
            660                 665                 670         


Asn Asn Asp Asp Met Phe Lys Lys Phe Thr Asn Glu Leu Met Ser Val 
        675                 680                 685             


Ile Arg Glu His Lys Val Ser Val Val Ala Leu Glu Lys Met Asp Ser 
    690                 695                 700                 


Met Leu Gly Asp Lys Ser Arg His Thr Phe Glu Asn Arg Asn Tyr Asn 
705                 710                 715                 720 


Leu Trp Pro Val Gly Gln Leu Lys Thr Phe Met Glu Gly Lys Leu Glu 
                725                 730                 735     


Ser Phe Asn Val Ala Leu Ile Glu Ile Asp Glu Arg Asn Thr Ser Gln 
            740                 745                 750         


Val Cys Lys Glu Asn Trp Ser Tyr Arg Glu Ala Asp Asp Leu Tyr Tyr 
        755                 760                 765             


Val Thr Asp Gly Glu Ser His Lys Val His Ala Asp Glu Asn Ala Ala 
    770                 775                 780                 


Asn Asn Ile Val Asp Arg Cys Ile Ser Arg His Thr Asn Met Phe Ser 
785                 790                 795                 800 


Leu His Met Val Asn Pro Lys Asp Asp Tyr Tyr Val Pro Thr Cys Ile 
                805                 810                 815     


Trp Asp Thr Thr Glu Glu Ser Gly Lys Arg Val Arg Gly Phe Leu Thr 
            820                 825                 830         


Lys Leu Tyr Lys Asn Ser Asp Val Val Phe Thr Lys Lys Gly Asp Lys 
        835                 840                 845             


Leu Val Lys Ser Lys Thr Ser Val Lys Glu Leu Lys Lys Leu Val Gly 
    850                 855                 860                 


Lys Thr Lys Glu Lys Arg Gly Gln Tyr Trp Tyr Arg Phe Glu Gly Lys 
865                 870                 875                 880 


Ser Trp Ile Asn Glu Ala Asp Arg Asp Thr Ile Ile Leu Asn Ala Lys 
                885                 890                 895     


Lys Ile Ser Arg Glu Arg Asp Asn Gly Glu Gln Ser Thr Asp Thr Arg 
            900                 905                 910         


Ser Gln Asn Val Thr Val Ser Val Leu Asp Val Cys Glu Thr Ala Glu 
        915                 920                 925             


Lys Lys Lys Leu Val Leu Val 
    930                 935 


<210>  3
<211>  887
<212>  PRT
<213>  ˹

<220>
<223>  Cas12h.1İ

<400>  3

Met Ala Leu Ile Gln Arg Ala Gly Val Leu Lys Thr Lys Ser Asp Phe 
1               5                   10                  15      


Pro Lys Val Ile Lys Asp Trp His Asp Ser Leu Leu Ala Asp Tyr Arg 
            20                  25                  30          


Lys Phe Phe Pro Ile Ile Phe Ser Trp Cys Pro Glu Tyr Gly Tyr Thr 
        35                  40                  45              


Thr Ile Gln Asp Asn Lys Pro Val Phe Val Ser Pro Glu Glu Arg Met 
    50                  55                  60                  


Glu Ser Ile Arg Lys Glu Ala Lys Glu His Leu Asn Glu Val Leu Ala 
65                  70                  75                  80  


Phe Gly Lys Met Ile Gly Ser Lys Gly Val Gly Gly Ser Ser Ser Tyr 
                85                  90                  95      


Ala Ile Phe Tyr Lys His His Lys Asn Asn Glu Asn Gly Ala Tyr Thr 
            100                 105                 110         


Pro Ser Arg Ala Lys Phe Met Lys Glu Gly Ile His Asn Arg Arg Val 
        115                 120                 125             


Glu Leu Val Asp Val Leu Met Leu Asn Ala Ile Pro Asp Glu Glu Trp 
    130                 135                 140                 


Val Lys Ile Ala Gln Glu Val Val Gly Tyr Ser Glu Glu Arg Leu Lys 
145                 150                 155                 160 


Leu Tyr Trp Asn Lys Phe Ile Ala Lys Arg Val Val Ser His Asp Arg 
                165                 170                 175     


Lys Leu Gly Lys Ile Val Arg Glu Lys Tyr Leu Glu Pro Lys Gly Leu 
            180                 185                 190         


Val Cys Ala Gln Pro Glu Asn Ser Thr Tyr Cys Arg Val Leu Thr Glu 
        195                 200                 205             


Ile Ile Lys Arg Gln Leu His Ser Gln Ile Glu Lys Ser Lys Phe His 
    210                 215                 220                 


Glu Glu Glu Leu Lys Ser Ile Glu Lys Thr Val Ser Glu Phe Asp Ser 
225                 230                 235                 240 


Pro Leu Leu Asp Phe Ile Cys Gln Tyr Ala Glu Glu Leu Asn Gln Ile 
                245                 250                 255     


Asn Ser Gly Leu Ser Lys Tyr Val Ile Lys Asn Ala Val Lys Glu Val 
            260                 265                 270         


Ile Ser Pro Pro Glu Lys Gln Ser Glu Ile Tyr Val Gln Ser Gln Val 
        275                 280                 285             


Leu Ser Gln Glu Lys Tyr Lys Pro Leu Val Asn Ala Thr Ile Lys Glu 
    290                 295                 300                 


Ile Leu Ser Gly Tyr Glu Gln Trp Lys Val Lys Ser Arg Tyr Glu Asn 
305                 310                 315                 320 


Arg Leu Lys Asn Arg Lys Tyr Val Leu Tyr Pro Lys Leu Ser Ala Asn 
                325                 330                 335     


Tyr Lys Ile Pro Ile Gly Gln Asn Ser Leu Gly Lys Phe Lys Ile Asn 
            340                 345                 350         


Val Ser Glu Asn Gly Glu Ile Val Ile Arg Leu Asn Asp Met Ala Asp 
        355                 360                 365             


Val Val Cys Met Pro Ser Lys Tyr Phe Phe Asn Leu Lys Ser Ser Pro 
    370                 375                 380                 


Val Val Asp Lys Lys Lys Gln Leu Val Gly Tyr Gln Ile Ser Phe Asn 
385                 390                 395                 400 


His Asn Ser Arg Arg Lys Glu Pro Thr Glu Lys Pro Asp Phe Asn Gly 
                405                 410                 415     


Ile Val Lys Glu Ile Gly Leu Gln Leu Lys Asp Asp Gly Arg Phe Tyr 
            420                 425                 430         


Ile Thr Leu Pro Tyr Cys Met Glu Tyr Ser Asn Asp Asn Phe Asp Leu 
        435                 440                 445             


Ile Arg Pro Leu Leu Thr Ser Ser Pro Thr Glu Asp Gln Ile Lys Lys 
    450                 455                 460                 


Met Pro Ser Glu Phe Asn Val Val Gly Phe Asp Leu Asn Leu Ser Met 
465                 470                 475                 480 


Pro Leu Pro Ile Thr Arg Ala Ile Val Gly Lys Ser Val Lys Gly Glu 
                485                 490                 495     


Ile Asn Val Glu Tyr Leu Gly Gln Ala Lys Val Ile Glu Ser Thr His 
            500                 505                 510         


Leu Ile Tyr Asp Asn Asn Arg Cys Lys Val Leu Ile Ala Tyr Lys Arg 
        515                 520                 525             


Gln Cys Asp Leu Ile Lys Arg Ala Ile Arg Glu Trp Lys Ile Cys Lys 
    530                 535                 540                 


Gly Lys Asn Ile Asp Ile Ser Glu Lys Thr Tyr Glu Trp Leu Glu Ser 
545                 550                 555                 560 


His Thr Lys Arg Trp Asn Pro Ser Arg Gln Pro Glu Ser Met Gln Asp 
                565                 570                 575     


Arg Phe Ser Val Ser Lys Met Arg Ile Gln Ile Leu Val Asn Lys Ala 
            580                 585                 590         


Lys Ser Arg Ile Ala Lys Tyr Asn Asp Asn Ser Trp Lys Thr Gly His 
        595                 600                 605             


Gly Asn Glu Ser Glu Leu Ile Arg Leu Ile Asp Ala Asp Asp Ala Tyr 
    610                 615                 620                 


Asn Ser Leu Val Ser Thr Tyr Asn Arg Ile His Leu Lys Ser Asn Gln 
625                 630                 635                 640 


Phe Ile Tyr Ala Leu Pro Ser Lys Asn Asn Ser Arg Ser Asn Lys Lys 
                645                 650                 655     


Glu Tyr Cys Leu Arg Arg Ile Ala Ala Lys Ile Ala Arg Tyr Cys His 
            660                 665                 670         


Leu His Asn Val Asn Ile Cys Ile Gly Glu Asn Leu Ser Phe Gln Gln 
        675                 680                 685             


Asp Ser Asp Asn Ile Ser Lys Asp Asn Ser Leu Val Arg Leu Phe Ser 
    690                 695                 700                 


Ser Lys Ser Ile Ala Asn Tyr Met Lys Leu Ala Met Glu Lys Phe Gly 
705                 710                 715                 720 


Ile Ala Phe Ile Asp Ser Ala Asp Pro Ser Gly Thr Ser Lys Thr Asp 
                725                 730                 735     


Pro Val Thr Gly Asn Ile Gly Tyr Arg Asn Lys Phe Asp Lys Arg Lys 
            740                 745                 750         


Leu His Val Ile Arg Asn Gly Asn Trp Gly Trp Val Asp Ser Asp Ile 
        755                 760                 765             


Ala Ala Ser Leu Asn Ile Leu Ile Arg Gly Ile Asn Arg Ser Ile Val 
    770                 775                 780                 


Pro Tyr Lys Phe Phe Val Gly Lys Lys Lys Gln Glu Ser Lys Arg Leu 
785                 790                 795                 800 


Asn His Phe Leu Asn Lys Ile Phe Gly Thr Thr Lys Val Phe Phe Tyr 
                805                 810                 815     


Glu Asp Gln Phe Gly Phe Ala Asn Pro Ser Leu Ser Lys Lys Glu Gly 
            820                 825                 830         


Glu Asn Leu Ile Ala Asn Gln Tyr Leu Tyr Tyr Arg Glu Gly Lys Phe 
        835                 840                 845             


Val Thr Gln Lys Ile His Arg Gln Ile Glu Asp Asp Phe Lys Lys Ile 
    850                 855                 860                 


Asp Phe Ser Asn Thr Pro Glu Val Asn Leu Ile Pro Ser Gly Val Lys 
865                 870                 875                 880 


Leu Lys Asn Phe Gln Phe Glu 
                885         


<210>  4
<211>  921
<212>  PRT
<213>  ˹

<220>
<223>  Cas12h.2İ

<400>  4

Met Ala Thr Arg Ser Phe Ile Arg Thr Gly Asn Leu Lys Ala Lys Asn 
1               5                   10                  15      


Thr Ala Glu Glu Val Met Gln Trp Tyr Ala Asp Leu Gln Ser Asp Tyr 
            20                  25                  30          


Arg Ser Phe Leu Asn Leu Phe Phe Gly Trp Met Ala Ile Gly Tyr Gly 
        35                  40                  45              


Thr Asn Ala Glu Asp Glu Val Phe Tyr Thr Ser Lys Glu Glu Ser Glu 
    50                  55                  60                  


Arg Leu Arg Ser Leu Thr Ile Gly Asp Ala Lys Lys Glu Gln Leu Ala 
65                  70                  75                  80  


Val Ser Phe Ile Glu Leu Leu Leu Lys Gly Gly Glu Asn Ala Ser Ser 
                85                  90                  95      


Cys Tyr Asn Val Phe Tyr Arg Asn Tyr Lys Ser Leu Gly Lys Ala Lys 
            100                 105                 110         


Leu Thr Gln Lys Lys Asn Asp Phe Leu Ser Ala Leu Pro Leu Leu Asp 
        115                 120                 125             


Glu Asn Lys Ile Lys Glu Tyr Phe Lys Thr Asp Glu Gln Leu Ser Gln 
    130                 135                 140                 


Ile Cys Ile Glu Glu Trp Leu Glu Tyr Gly Val Lys Asn Leu Pro Leu 
145                 150                 155                 160 


Pro Glu Ile Trp Ala Glu Val Ser Pro Arg Leu Ala Ser Ile Glu Arg 
                165                 170                 175     


Ser Leu Gly Val Asp Leu Arg Leu Ala Phe Gly Leu Ser Cys Ile Arg 
            180                 185                 190         


Ser Arg Asp Cys Asn Tyr Cys Arg Ile Leu Ile Glu Met Val Gly Arg 
        195                 200                 205             


Asp Leu Arg Ser Ile Phe Glu Lys Tyr Asn Asn His Leu Leu Glu Thr 
    210                 215                 220                 


Glu Lys Ile Lys Leu Ser Met Asn Asp Lys Gln Gly Pro Val Tyr Asp 
225                 230                 235                 240 


Ser Ile Cys Cys Phe Ala Ala Glu Leu Glu Ser Lys Asn Ser Gly Leu 
                245                 250                 255     


Thr Lys Tyr Val Leu Thr Lys Gly Ile Asp His Val Lys Lys Gly Thr 
            260                 265                 270         


Gly Glu Lys Thr Asp Ile Arg Leu Ala Val Lys Glu Leu Lys Lys Asn 
        275                 280                 285             


Lys Tyr Arg Ile Leu Ile Glu Ser Ser Tyr Ser Glu Ile Met Ser Ala 
    290                 295                 300                 


Tyr Ser Cys Trp Arg Thr Lys Lys Gln Leu Glu Lys Arg Lys Leu Tyr 
305                 310                 315                 320 


Pro Cys Phe Asp Pro Asn Arg Asn Asp Tyr Lys Val Pro Val Gly Gln 
                325                 330                 335     


Gly Ser Leu Gly Asn Phe Thr Val Ser Val Glu Asp Ser Gly Asp Val 
            340                 345                 350         


Leu Ile Glu Ile Val Gly Val Gly Val Ile Arg Cys Ala Ala Ser Cys 
        355                 360                 365             


Tyr Phe Ser Gly Ile Val Phe Asp Glu Ile Arg Asn Lys Asn Gly Arg 
    370                 375                 380                 


Thr Gly Tyr Ser Leu Asn Phe Cys His Lys Ser Ile Ser Lys Gly Lys 
385                 390                 395                 400 


Lys Ala Val Lys Ala Ala Ser His Thr Gly Asp Lys Ile Ser Gly Val 
                405                 410                 415     


Leu Lys Glu Ile Gly Leu Arg Asn Thr Asp Ser Gly Phe Phe Val Ser 
            420                 425                 430         


Leu Pro Tyr Ser Ile His His Asp Glu Lys Asn Phe Lys Ile Ala Glu 
        435                 440                 445             


Phe Phe Met Ser Ala Cys Pro Lys Lys Glu Asn Val Glu Asn Leu Pro 
    450                 455                 460                 


Asp Lys Ile Val Val Gly Ala Ile Asp Leu Asn Val Ser Asn Pro Val 
465                 470                 475                 480 


Ala Ala Val Lys Ala Val Val Tyr Arg Asp Asp Lys Ser Gly Gln Leu 
                485                 490                 495     


Asn Ala Leu Asp Tyr Gly Ser Gly Asn Leu Ile Lys Lys Pro Phe Met 
            500                 505                 510         


Leu Val Ala Asn Gly Pro Arg Ile Lys Asn Leu Ile Glu Ile Arg Asp 
        515                 520                 525             


Asp Ala Arg Arg Val Ile Gly Ala Ile Arg Glu Phe Lys Val Ser Asn 
    530                 535                 540                 


Ala Val Lys Glu His Val Gly Glu Asp Thr Arg Asp Phe Leu Ile Leu 
545                 550                 555                 560 


Cys Gly Asp Thr Lys Ser Ser Ser Thr Arg Tyr Leu Ile Gln Ser Trp 
                565                 570                 575     


Val Lys Lys Ile Asn Ser Arg Leu Arg Lys Ile Lys Phe Glu Met Arg 
            580                 585                 590         


Ser Gly Gly Tyr Arg Asp Cys Ala Asp Asn Ile Arg Leu Ile Glu Ala 
        595                 600                 605             


Met Asp Gln Cys Ala Ser Met Ala Glu Ser Tyr Asn Arg Ile His Leu 
    610                 615                 620                 


Lys Ser Gly Glu Lys Leu Val Lys Val Ala Lys Phe Asp Lys Ser Arg 
625                 630                 635                 640 


Ala Asn Phe Arg Asn Phe Val Leu Arg Gln Leu Ala Ser Lys Ile Ala 
                645                 650                 655     


Asn Glu Met Lys Asp Cys Asn Val Val Phe Gly Glu Asp Leu Asp Phe 
            660                 665                 670         


Ile Phe Asp Ser Asp Lys Asn Asn Asn Ala Leu Leu Arg Leu Phe Ser 
        675                 680                 685             


Ala Ala Thr Leu Leu Lys Tyr Ile Ile Glu Ala Leu Glu Lys Ile Gly 
    690                 695                 700                 


Val Gly Phe Val Lys Val Ala Lys Asn Gly Thr Ser Gln Ser Asp Pro 
705                 710                 715                 720 


Val Thr Ser Asn Pro Gly Trp Arg Asp Asp Lys Asn Lys Ser Arg Leu 
                725                 730                 735     


Tyr Val Val Arg Asp Lys Gln Leu Gly Trp Ile Asp Ser Asp Leu Ala 
            740                 745                 750         


Ala Thr Met Asn Ile Leu Ile Gln Gly Leu Asn His Ser Val Cys Pro 
        755                 760                 765             


Tyr Lys Phe Tyr Val Lys Glu Tyr Glu Asn Lys Pro Asn Ser Thr Gln 
    770                 775                 780                 


Asp Ser Ile Asn Ala Ile Lys Lys Pro Glu Glu Ala Ile Gly Lys Arg 
785                 790                 795                 800 


Ile Lys Arg Phe Phe Asn Leu Lys Tyr Gly Ser Ser Val Pro Lys Phe 
                805                 810                 815     


Val Ser Asp Asp Arg Gly Arg Val Thr Phe Ala Lys Lys Ile Asp Ser 
            820                 825                 830         


Thr Gln Thr Arg Leu Ile Asn Gln Phe Val Tyr Ala His Ser Ser Cys 
        835                 840                 845             


Ile Val Thr Cys Glu Leu His Asn Glu Met Val Asn Lys Ile Lys Gln 
    850                 855                 860                 


Leu Ala Val Glu Lys Pro Asn Cys Gln Glu Phe Asp Val Thr Cys Asp 
865                 870                 875                 880 


Pro Asp Gly Arg Tyr Asn Asn Phe Ala Leu Pro Glu Val His Asp Ser 
                885                 890                 895     


Ser Lys Asp Val Gly Ala Lys Ala Leu Thr Thr Lys Asp Val Asp Phe 
            900                 905                 910         


Lys Thr Ile Leu Lys Asp His Thr Ala 
        915                 920     


<210>  5
<211>  1297
<212>  PRT
<213>  ˹

<220>
<223>  Cas12w.1İ

<400>  5

Met Gly Lys Asn Glu Asn Lys Tyr Gln Leu Ser Lys Thr Leu Arg Phe 
1               5                   10                  15      


Gly Leu Thr Leu Lys Glu Lys Ile Ser Asn Asn Glu Lys Thr Pro Tyr 
            20                  25                  30          


Gln Ser His Ser Gln Phe Arg Asp Leu Ile Ile Leu Ser Glu Asn Arg 
        35                  40                  45              


Ile Arg Glu Gly Ile Ser Thr Pro Gln Asn Arg Asp Leu Pro Ser Phe 
    50                  55                  60                  


Ile His Arg Ile Gln Asn Cys Thr Asp Phe Ile Asn Asp Phe Ile His 
65                  70                  75                  80  


Asp Trp Trp Met Ile Leu Met His Thr Gly Gln Ile Glu Leu Asp Lys 
                85                  90                  95      


Asp Tyr Tyr Lys Ser Leu Thr Lys Lys Val Gly Phe Val Gly Phe Trp 
            100                 105                 110         


Tyr Lys Glu Asn Lys Lys Lys Gly Gly Lys Thr Lys Gln Pro Gln Ala 
        115                 120                 125             


Arg Asn Ile Pro Met Gly Glu Leu Arg His Leu Cys Pro Gln Asn Thr 
    130                 135                 140                 


Lys Glu Cys Ala Thr Tyr Ile Thr Asp Tyr Trp Lys Asp Leu Leu Ile 
145                 150                 155                 160 


Thr Ala Thr Asn Lys Leu Tyr Glu Ser Ser Glu Gln Gln Lys Lys Phe 
                165                 170                 175     


Ile Lys Ala Met Glu Gln Asn Arg Thr Asp Asn Lys Pro Asn Glu Ile 
            180                 185                 190         


Asp Leu Lys Lys Ser Phe Leu Ser Leu Val Ser Val Thr Met Glu Leu 
        195                 200                 205             


Leu Asn Pro Ile Leu Asn Gly Gln Ile Leu Phe Asn Lys Met Asp Arg 
    210                 215                 220                 


Leu Asp Met Ser Lys Lys Ser Asp Asn Asp Phe Ile Asp Phe Val Asn 
225                 230                 235                 240 


Asp His Glu Thr Val Arg Glu Leu Asn Asn Asp Ile Glu Glu Ile Ile 
                245                 250                 255     


Ala Asp Phe Lys Glu Asn Gly Asn Asn Val Asn Tyr Cys Lys Ala Thr 
            260                 265                 270         


Leu Asn Pro Asp Thr Ala Leu Lys Gln His Asn Asn Asn Ile Pro Asn 
        275                 280                 285             


Asp Ile Ala Thr Asp Leu Glu Glu Leu Met Met Asp Ser Ile Val Gly 
    290                 295                 300                 


Asn Tyr Asp Asp Val Asn Ser Phe Met Asp Asn Tyr Val Ser Asn Leu 
305                 310                 315                 320 


Ser Ala Lys Asp Lys Ile Lys Lys Ile Lys Asp Ser Asn Ile Ser Leu 
                325                 330                 335     


Ile Tyr Arg Ala Ile Leu Phe Lys Tyr Lys Met Ile Pro Ala Asn Val 
            340                 345                 350         


Arg Arg Asp Ile Ala Gln Gly Met Ala Lys Lys Leu Asn Lys Asp Glu 
        355                 360                 365             


Glu Asn Ile Tyr Ser Phe Leu Cys Glu Phe Gly Thr Leu Arg Thr Pro 
    370                 375                 380                 


Gln Lys Asp Tyr Ala Asp Leu Lys Asp Lys Asp Ser Phe Asn Leu Asp 
385                 390                 395                 400 


Asn Tyr Pro Leu Lys Val Ala Phe Asp Phe Ala Trp Glu Gly Leu Ala 
                405                 410                 415     


Lys Ala Trp Tyr His Asp Gln Ser Asp Phe Pro Ile Asp Pro Cys Arg 
            420                 425                 430         


Asp Phe Leu Gln Glu Asn Phe Asp Val Asn Leu Glu Glu Asp Gln Glu 
        435                 440                 445             


Asp Glu Tyr Phe Leu Leu Tyr Ala Asp Leu Ile Glu Leu Asn Ala Leu 
    450                 455                 460                 


Leu Ser Thr Leu Asp Lys Gly Asn Pro Ala Asp Pro Asp Ser Ile Lys 
465                 470                 475                 480 


Asn Glu Ala Leu Glu Met Val Glu Tyr Ile Asn Trp Asn Ser Leu Asp 
                485                 490                 495     


Lys Lys Asn Gly Asn Tyr Tyr Lys Lys Ile Ile Lys Asn Arg Leu Lys 
            500                 505                 510         


Ser Ser Lys Gly Asn Glu Thr Tyr Glu Arg Ile Lys Lys Glu Ile Ser 
        515                 520                 525             


Met Ser Arg Gly Arg Leu Lys Asn Lys Ile Glu Lys Tyr Asp Asp Leu 
    530                 535                 540                 


Thr Ser Gln Tyr Lys Arg Ile Ala Met Asp Leu Gly Lys Lys Phe Ala 
545                 550                 555                 560 


Ser Leu Arg Asp Lys Ile Ile Ala Ala Asn Glu Asp Asn Lys Val Thr 
                565                 570                 575     


His Tyr Ala Met Ile Leu Glu Asp Ser Asn Cys Asp Lys Tyr Leu Leu 
            580                 585                 590         


Leu Gln Lys Val Ser Asn Asn Ile Tyr His Cys Met Ser Tyr Asp Ser 
        595                 600                 605             


Ser Asp Pro Lys Ala Tyr Tyr Val Asp Ser Ile Thr Ser Ser Ala Ile 
    610                 615                 620                 


Ala Lys Met Ile Arg Lys Glu Thr Asn Pro Ser Lys Ile Arg Glu Tyr 
625                 630                 635                 640 


Ala Glu Leu Glu Glu Lys Glu Arg Glu Arg Arg Asn Val Asp Asp Trp 
                645                 650                 655     


Cys Arg Phe Ile Ser Lys Lys Glu Tyr Asp Arg Arg Tyr Gln Leu Asn 
            660                 665                 670         


Ile Asn Asn Gly Leu Ser Phe Glu Ala Leu Lys Lys Glu Ile Asp Ser 
        675                 680                 685             


Lys Ser Tyr Ile Leu Val Lys Lys Asn Ile Ser Val Asp Ser Ile Arg 
    690                 695                 700                 


Glu Leu Val Glu Asn Glu Gly Cys Leu Leu Phe Pro Ile Val Asn Lys 
705                 710                 715                 720 


Asp Leu Thr Lys Glu Arg Lys Thr Thr Glu Asp Asn Gln Phe Thr Lys 
                725                 730                 735     


Asp Trp Asn Met Ile Phe Ser Gly Ser Glu Thr Asn Trp Arg Leu Thr 
            740                 745                 750         


Pro Glu Phe Arg Val Thr Tyr Arg Asn Pro Val Pro Gly Tyr Pro Asn 
        755                 760                 765             


Asp Lys Phe Gly Ser Lys Arg Tyr Ser Arg Phe Gln Met Asn Ala His 
    770                 775                 780                 


Phe Val Cys Asp Phe Ile Pro Ser Ser Asn Ser Tyr Thr Ser Asn Arg 
785                 790                 795                 800 


Glu Gln Ile Ala Ile Phe Lys Asp Glu Gly Glu Gln Lys Lys Arg Val 
                805                 810                 815     


Glu Glu Phe Asn Arg Thr Leu Ser Asn Ile Asn Gln Lys Phe Tyr Val 
            820                 825                 830         


Ile Gly Ile Asp Arg Gly Gln Lys Glu Leu Ala Thr Leu Cys Val Val 
        835                 840                 845             


Asp Gln Asp Lys Lys Ile His Gly Asp Phe Lys Ile Tyr Thr Arg Lys 
    850                 855                 860                 


Phe Asn Ser Glu Arg Lys Gln Trp Glu His Tyr Ser Leu Glu Gly Glu 
865                 870                 875                 880 


Lys Gly Thr Arg Asn Ile Leu Asp Leu Ser Asn Leu Arg Val Glu Thr 
                885                 890                 895     


Thr Ile Ile Ile Asp Gly Lys Pro Glu Arg Arg Gln Val Leu Val Asp 
            900                 905                 910         


Leu Ser Glu Val Leu Val Lys Asp Lys Glu Gly Asn Tyr Thr Lys Pro 
        915                 920                 925             


Asn Lys Met Gln Ile Lys Met Gln Gln Met Ala Tyr Val Arg Lys Leu 
    930                 935                 940                 


Gln Phe Gln Met Gln Ala Asn Pro Thr Glu Val Leu Glu Trp Tyr Glu 
945                 950                 955                 960 


Gln Asn Pro Thr Glu Glu Leu Ile Ile Lys Asn Leu Val Asp Lys Glu 
                965                 970                 975     


Asn Gly Glu Lys Gly Leu Ile Ser Phe Tyr Gly Thr Ala Leu Val Glu 
            980                 985                 990         


Leu Asp Gln Thr Leu Pro Val Ser  Lys Ile Lys Glu Met  Leu Glu Glu 
        995                 1000                 1005             


Phe Lys  Ile Leu Lys Gln Arg  Glu Ser Lys Lys Glu  Asn Val Gln 
    1010                 1015                 1020             


Lys Glu  Leu Asn Asn Leu Thr  Gln Leu Glu Ala Val  Asp Ser Leu 
    1025                 1030                 1035             


Lys Ala  Gly Ile Val Ala Asn  Met Val Gly Val Ile  Ser Tyr Ile 
    1040                 1045                 1050             


Leu Lys  Thr Leu Asp Tyr Asn  Ala Tyr Ile Ser Leu  Glu Asp Leu 
    1055                 1060                 1065             


Ser Thr  Val Gln Ser Ser Thr  Glu Phe Ala Ser Gly  Ile Ser Gly 
    1070                 1075                 1080             


Ala Ile  Thr Lys Met Ser Arg  Glu Glu Gly Arg Arg  Ile Asp Val 
    1085                 1090                 1095             


Glu Lys  Tyr Ala Gly Leu Gly  Leu Tyr Asn Phe Phe  Glu Met Gln 
    1100                 1105                 1110             


Leu Leu  Arg Lys Leu His Arg  Ile Gln Thr Asp Asn  Gly Asn Ile 
    1115                 1120                 1125             


Leu His  Leu Val Pro Ala Phe  Arg Ala Gln Lys Asn  Tyr Asp His 
    1130                 1135                 1140             


Ile Met  Val Gly Lys Glu Lys  Ile Lys Asn Gln Phe  Gly Ile Val 
    1145                 1150                 1155             


Phe Phe  Val Asp Ala Ala Ala  Thr Ser Ile Lys Cys  Pro Arg Cys 
    1160                 1165                 1170             


Gly Ala  Val Asn Glu Asp Lys  Phe Asn Pro Asp Lys  Gln Lys Tyr 
    1175                 1180                 1185             


Pro Asp  Ala Glu Lys Gly Pro  Lys Leu Arg Asn Arg  Lys Glu Gln 
    1190                 1195                 1200             


Ser Gly  Lys Lys Val Trp Val  Thr Arg Asp Lys Glu  Asp Asp Asp 
    1205                 1210                 1215             


Arg Ile  Lys Cys Tyr Cys Cys  Gly Phe Asp Thr Lys  Glu Lys Asn 
    1220                 1225                 1230             


Glu Gly  Asn Pro Phe Met Tyr  Ile Lys Ser Gly Asp  Asp Asn Ala 
    1235                 1240                 1245             


Ala Tyr  Leu Ile Ser Asp Leu  Gly Val Glu Ser Tyr  Arg Lys Ala 
    1250                 1255                 1260             


Tyr Glu  Leu Ala Ala Thr Val  Val Glu Asp Arg Lys  Lys Thr Leu 
    1265                 1270                 1275             


Thr Asn  Asn Leu Asn Gln Ser  Asn Tyr Lys Ile Arg  Phe Leu Trp 
    1280                 1285                 1290             


His Thr  Met Tyr 
    1295         


<210>  6
<211>  1257
<212>  PRT
<213>  ˹

<220>
<223>  Cas12w.2İ

<400>  6

Met Asp Ala Asp Lys Thr Thr Lys Ala Ile Asn Glu Tyr Gln Thr Gln 
1               5                   10                  15      


Lys Thr Ile Arg Phe Gly Leu Thr Ala Thr Asn Gln Asn Leu Tyr Ser 
            20                  25                  30          


Glu Glu Ile Met Lys Leu Leu Asn Ile Ser Glu Glu Arg Ile Ile Lys 
        35                  40                  45              


Glu Lys Val Lys Val Asn Asn Asp Thr Asp Lys Thr Asn Gln Leu Arg 
    50                  55                  60                  


Gly Cys Leu Val Gln Ile Lys Lys Tyr Leu Lys Thr Trp Glu Asn Ile 
65                  70                  75                  80  


Tyr Ala Gln Ile Asp Phe Leu Ala Ile Thr Lys Asp Tyr Tyr Lys Val 
                85                  90                  95      


Ile Ser Lys Lys Ala Arg Phe Asp Phe Asp Lys Gly Asn Gly Ser Glu 
            100                 105                 110         


Ile Lys Leu Ser Ser Leu Gln Ser Thr His Asn Lys Lys Lys Arg Tyr 
        115                 120                 125             


Gln Tyr Ile Ile Asp Phe Trp Lys Glu Asn Leu Arg Lys Thr Glu Asn 
    130                 135                 140                 


Leu Tyr Arg Lys Ser Asp Asp Leu Leu Lys Ile Phe Glu Glu Ala Lys 
145                 150                 155                 160 


Asn Gln Asn Arg Asp Asp Lys Lys Leu Asn Lys Val Glu Leu Arg Lys 
                165                 170                 175     


Thr Phe Leu Asn Leu Phe Thr Leu Val Asn Glu Ser Leu Lys Pro Leu 
            180                 185                 190         


Ile Glu Gly Asn Leu Phe Ile Val Asn Asp Asp Lys Ile Asp Glu Lys 
        195                 200                 205             


Asn Ser Lys His Asn Tyr Val Phe Tyr Phe Ile Ser Lys Thr Glu Glu 
    210                 215                 220                 


Arg Arg Leu Leu Tyr Asp Asn Ile Cys Thr Leu Gln Asp Tyr Phe Lys 
225                 230                 235                 240 


Asn Asn Gly Gly Tyr Val Pro Phe Gly Arg Val Thr Leu Asn Lys Trp 
                245                 250                 255     


Thr Ala Leu Gln Lys Phe Asn Asn Arg Asp Ile Glu Ile Asn Arg Ile 
            260                 265                 270         


Ile Lys Glu Leu Lys Ile Asn Asn Ile Ser Thr Gln Lys Thr Asp Tyr 
        275                 280                 285             


Lys Tyr Asn Asp Phe Thr Glu Asn Phe Lys Glu Lys Lys Asp Glu Asn 
    290                 295                 300                 


Gly Lys Val Val Lys Asn Ser Ala Gly Asn Ile Ile Trp Asp Leu Lys 
305                 310                 315                 320 


Ala Asn Ala Lys Ser Val Ile Glu Ile Cys Gln Phe Phe Lys Tyr Lys 
                325                 330                 335     


Lys Val Pro Ile Asn Ala Arg Leu Asn Leu Ala Lys Arg Leu Ile Lys 
            340                 345                 350         


Asp Asn Lys Leu Lys Lys Glu Gln Glu Asn Thr Phe Leu Ser Glu Phe 
        355                 360                 365             


Gly Val Leu Lys Thr Pro Ala Phe Asp Tyr Ala Arg Asp Lys Glu Asn 
    370                 375                 380                 


Phe Asn Leu Thr Asn Tyr Pro Leu Lys Val Ala Phe Asp Tyr Ala Trp 
385                 390                 395                 400 


Glu Asn Cys Ala Lys Asp Lys Tyr Glu Lys Ile Pro Phe Pro Lys Glu 
                405                 410                 415     


Gln Cys Glu Arg Tyr Leu Gln Thr Ala Phe Glu Ile Asp Ala Thr Lys 
            420                 425                 430         


Asp Glu Asn Lys Lys Leu Ile Asp Thr His Leu Asn Lys Tyr Ala Asp 
        435                 440                 445             


Leu Leu Gln Phe Lys Ile Leu Leu Glu Arg Phe Lys Ala Glu Phe His 
    450                 455                 460                 


Lys Thr Asn Glu Glu Thr Asn Lys Asn Asn Ile Gln Lys Leu Arg Asn 
465                 470                 475                 480 


Val Phe Ser Gly Leu Asp Tyr His Gly Asp Asn Arg Leu Asn Lys Asn 
                485                 490                 495     


Gln Ile Gln Lys Ala Ile Glu Ala Trp Phe Asp Asn Lys Glu Gln Asn 
            500                 505                 510         


Ile Gly Lys Lys Lys Glu Asn Glu Lys Leu Leu Thr Glu Asn Glu Lys 
        515                 520                 525             


Asn Asn Phe Ser Leu Ser Met Gln Ile Ile Gly Gln Glu Arg Gly Gly 
    530                 535                 540                 


Leu Lys Asn Gly Ile Pro Lys Tyr Lys Glu Leu Thr Glu Met Phe Lys 
545                 550                 555                 560 


Val Cys Ala Ser Lys Phe Gly Lys Gln Phe Ala Asp Leu Arg Asp Tyr 
                565                 570                 575     


Phe Asn Glu Ala Tyr Glu Val Asp Lys Ile Lys Tyr Arg Ala Trp Ile 
            580                 585                 590         


Ile Glu Asp Asp Lys Lys Asn Arg Phe Val Leu Phe Val Asn Lys Glu 
        595                 600                 605             


Lys Ala Phe Asp Leu Thr Ser Glu Glu Gly Asp Leu Trp Phe Tyr Glu 
    610                 615                 620                 


Val Lys Ser Leu Thr Ser Lys Ser Leu Val Lys Phe Ile Lys Asn Arg 
625                 630                 635                 640 


Gly Ala Tyr Pro Asp Phe His Asp Val Lys Asn Ser Phe His Tyr Ser 
                645                 650                 655     


Ser Ile Lys Lys Asp Trp Gln Asn Tyr Lys Asn Asp Pro Glu Phe Leu 
            660                 665                 670         


Asp Lys Leu Lys Glu Cys Leu Lys Asn Ser Lys Ile Ala Lys Asp Gln 
        675                 680                 685             


Lys Trp Ala Lys Phe Cys Trp Asp Phe Lys Gln Cys Asp Thr Tyr Glu 
    690                 695                 700                 


Lys Leu Glu Lys Glu Val Asp Arg Lys Gly Tyr Lys Leu Glu Gly Cys 
705                 710                 715                 720 


Lys Ser Glu Pro Lys Thr Ile Ser Leu Thr Gln Leu Thr Asp Trp Val 
                725                 730                 735     


Glu Asn Lys Asp Cys Phe Leu Leu Pro Ile Val Asn Gln Asp Ile Asn 
            740                 745                 750         


Lys Gly Asp Lys Arg Thr Lys Asn Gln Asn Gln Phe Thr Lys Asp Trp 
        755                 760                 765             


Phe Asp Ile Phe Glu Asn Lys Lys Arg Leu His Pro Glu Phe Asn Ile 
    770                 775                 780                 


Phe Tyr Arg Phe Pro Thr Lys Asp Tyr Pro Asn Thr Lys Phe Lys Asn 
785                 790                 795                 800 


Gly Thr Glu Lys Thr Lys Arg Tyr Ser Arg Phe Gln Met Leu Ala Tyr 
                805                 810                 815     


Phe Gly Cys Glu Val Ile Pro Ser Gly Asn His Leu Ser Lys Lys Glu 
            820                 825                 830         


Gln Ile Ala Ile Phe Asn Asn Asp Lys Lys Gln Lys Glu Glu Val Glu 
        835                 840                 845             


Lys Tyr Asn Lys Ser Ile Ser Ser Asp Cys Asp Tyr Val Ile Gly Ile 
    850                 855                 860                 


Asp Arg Gly Ile Lys Gln Leu Ala Thr Leu Cys Val Leu Asp Lys Asn 
865                 870                 875                 880 


Gly Val Ile Gln Gly Asp Phe Gln Ile Phe Thr Arg Thr Phe Asn Lys 
                885                 890                 895     


Gln Thr Lys Gln Trp Glu His Lys Glu Leu Glu Gln Arg Asn Ile Leu 
            900                 905                 910         


Asp Leu Ser Asn Leu Arg Val Glu Thr Thr Ile Thr Gly Lys Lys Val 
        915                 920                 925             


Leu Val Asp Leu Ser Lys Ile Lys Asp Asp Glu Gly Asn Tyr Thr Asn 
    930                 935                 940                 


Leu Lys Gln Thr Ile Lys Leu Lys Gln Leu Ala Tyr Ile Arg Glu Leu 
945                 950                 955                 960 


Gln Tyr Ala Met Gln Thr Arg Pro Asp Asp Leu Leu Asp Phe Val Lys 
                965                 970                 975     


Ser Ile Asn Ser Ala Asn Asp Ile Thr Ala Glu Asn Ile Lys His Phe 
            980                 985                 990         


Ile Ser Pro Tyr Lys Glu Gly Lys  Asn Tyr Asp Asp Leu  Pro Lys Val 
        995                 1000                 1005             


Glu Met  Phe Asn Leu Leu Lys  Glu Trp Gly Asn Ala  Asp Glu Asn 
    1010                 1015                 1020             


Gly Lys  Arg Lys Ile Ala Glu  Leu Asp Pro Ala Asp  Asn Leu Lys 
    1025                 1030                 1035             


Ser Gly  Ile Val Ala Asn Met  Val Gly Val Val Ala  Phe Leu Cys 
    1040                 1045                 1050             


Glu Asn  Tyr Asn Tyr Lys Val  Arg Ile Ala Leu Glu  Asp Leu Thr 
    1055                 1060                 1065             


Arg Ala  Tyr Gly Ile Gln Lys  Asp Ala Leu Asn Gly  Thr Ala Ile 
    1070                 1075                 1080             


Tyr Gln  Asn Asp Glu Asp Phe  Lys Glu Gln Glu Asn  Arg Arg Leu 
    1085                 1090                 1095             


Ala Gly  Val Gly Thr Met Gln  Phe Phe Glu Val Gln  Leu Leu Arg 
    1100                 1105                 1110             


Lys Leu  Phe Lys Ile Gln Val  Asp Lys Asn Leu His  Leu Ile Pro 
    1115                 1120                 1125             


Ala Phe  Arg Ser Val Asp Asn  Tyr Glu Lys Ile Val  Arg Arg Asp 
    1130                 1135                 1140             


Lys Gln  Asn Ser Gly Asp Glu  Phe Val Asn Tyr Pro  Phe Gly Ile 
    1145                 1150                 1155             


Val Cys  Phe Val Asp Pro Lys  Tyr Thr Ser Gln Gln  Cys Pro Tyr 
    1160                 1165                 1170             


Cys Asn  Asn Thr His Lys His  Lys Lys Asn Asp Thr  Glu Thr Gly 
    1175                 1180                 1185             


Lys Lys  Ala Phe Tyr Arg Asn  Lys Gly Glu Asn Lys  Asn Ser Leu 
    1190                 1195                 1200             


Leu Cys  Glu Lys Cys Gly Val  Ser Thr Ile Glu Gly  Glu Glu Thr 
    1205                 1210                 1215             


Leu Ser  Ser Lys Asn Asp Asn  Lys Lys Gln Phe Asn  Ile His Tyr 
    1220                 1225                 1230             


Ile Thr  Asp Gly Asp Gln Asn  Gly Ala Tyr His Ile  Ala Asn Lys 
    1235                 1240                 1245             


Val Val  Ile Asn Phe Gln Lys  Asp Ser 
    1250                 1255         


<210>  7
<211>  1011
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.1İ

<400>  7

Met Asp Tyr Gln Gln Tyr Glu Phe Thr Arg Thr Ile Arg Phe Asn Leu 
1               5                   10                  15      


Ser Gly Asp Asp Lys Arg Ala Leu Met Leu Asp Leu Leu Asp Asp Thr 
            20                  25                  30          


Gln Glu Gly Met Leu Ala Ala Phe Gln Glu Thr Tyr Lys Asn Leu Leu 
        35                  40                  45              


Phe Ala Phe Gln Glu Ala Ile Leu Arg Ala Asp Gly Ser Gly Asn Leu 
    50                  55                  60                  


Arg Val Gly Arg Leu Glu Ile Lys Lys Ser Trp Leu Arg Gln Tyr Ala 
65                  70                  75                  80  


Arg Glu Tyr Phe Tyr Ala Leu Ser Glu Asp Glu Arg Arg Cys Lys Asn 
                85                  90                  95      


Lys Phe Gln Ala Lys Leu Phe Asp Arg Val Leu Ser Asp Trp Leu Glu 
            100                 105                 110         


Arg Asn Asn Glu Leu Leu Gln Arg Leu Asn Asn Ile Leu Ser Leu Pro 
        115                 120                 125             


Gln Glu Ser Lys Thr Gly Ala Ser Asp Leu Ser Leu Leu Val Arg Gln 
    130                 135                 140                 


Leu Lys Gly Ala Glu Tyr Phe Tyr Phe Ile Arg Asp Phe Thr Gln Ser 
145                 150                 155                 160 


Gly Ile Ile Asn Asp Lys Asp Ser Asp Glu His Ile Lys Asn Leu Ala 
                165                 170                 175     


Gly Ile Val Glu Lys Phe Glu Thr Leu Leu Asp Lys Val Leu Phe Leu 
            180                 185                 190         


Thr Ala Pro Asn Ser Ser Gln Gly Val Glu Thr Thr Arg Ala Ser Phe 
        195                 200                 205             


Asn Tyr Tyr Thr Val Asn Lys Ile Ser Lys Asn Phe Asp Glu Asn Ile 
    210                 215                 220                 


Lys Lys Ala Asn Gly Arg Leu Cys Ser Ser Tyr Gln Asn Ser Met Asn 
225                 230                 235                 240 


Glu Glu Leu Leu Arg Lys Val Gly Phe Leu Lys Tyr Leu Lys Asp Glu 
                245                 250                 255     


Tyr Arg Ala Glu Leu Gln Asn Val Ser Leu Lys Asp Leu Tyr Glu Ala 
            260                 265                 270         


Leu Lys Lys Phe Lys Ser Gln Gln Lys Thr Ala Phe Ile Gln Ala Val 
        275                 280                 285             


Gln Lys Asn Lys Ser Glu Lys Glu Leu Met Arg Glu Phe Pro Leu Phe 
    290                 295                 300                 


Asn Gly Lys Gln Pro Asp Thr Leu Gln Lys Phe Ile Leu Glu Thr Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Gly Ala Tyr Phe Gln Lys Trp Gly Phe Asp Asn Tyr 
                325                 330                 335     


Ile Ser Phe Cys Asn Lys Ile Phe Lys Pro Val Ala Met Glu Thr Gly 
            340                 345                 350         


Thr Arg Lys Ala Lys Ile Arg Ala Leu Glu Gln Glu Lys Ile Glu Ala 
        355                 360                 365             


Arg Leu Leu Gln Tyr Trp Ala His Ile Leu Val Lys Asp Gly Lys Tyr 
    370                 375                 380                 


Phe Leu Leu Leu Ile Pro Lys Glu Lys Met Gly Glu Ala Lys Val Phe 
385                 390                 395                 400 


Phe Ala Arg Leu Ser Asp Gln Glu Gly Gly Glu Tyr Thr Leu Tyr Ala 
                405                 410                 415     


Phe Asn Ser Leu Thr Leu Arg Ala Leu Lys Lys Leu Ile Arg Arg Asn 
            420                 425                 430         


Leu Gly Lys Glu Gln Val Arg Leu Ser Ala Gly Asp Ala Asp Ala Ile 
        435                 440                 445             


Ala Leu Cys Gln Glu Val Leu Arg Gly Arg Tyr His Gln Leu Lys Asp 
    450                 455                 460                 


Leu Asp Leu Ser Gly Phe Glu Lys Glu Ile Ala Glu Ile Ala Asn Thr 
465                 470                 475                 480 


Gln Tyr Glu Asn Glu Glu Glu Phe Arg Ile Ala Leu Glu Gln Val Ala 
                485                 490                 495     


Tyr Tyr Leu Ser Glu Arg Lys Met Asn Glu Glu Ser Ile Glu Tyr Leu 
            500                 505                 510         


Lys Lys Asn Leu Gly Ala Ile Leu Leu Glu Ile Ser Ser Tyr Asp Leu 
        515                 520                 525             


Glu Arg Asn Ile Thr Gly Glu Ser Lys Glu His Thr Arg Leu Trp Ser 
    530                 535                 540                 


Asp Phe Trp Asn Pro Asn Asn Lys Lys Glu Cys Phe Ser Thr Arg Leu 
545                 550                 555                 560 


Asn Pro Glu Leu Arg Ile Phe Tyr Arg Pro Pro Arg Glu Gln Lys Asp 
                565                 570                 575     


Pro Lys Lys Gln Lys Asn Arg Phe Ser Lys Asp His Leu Ala Val Ala 
            580                 585                 590         


Phe Thr Ile Ala Gln Asn Ala Ala Arg Lys Arg Met Glu Thr Ser Phe 
        595                 600                 605             


Ala Glu Glu Lys Asp Leu Val Glu Gln Val Lys Lys Phe Asn Glu Glu 
    610                 615                 620                 


Val Val Gly Lys Phe Ile Asp Glu Lys Ser Asp Asn Leu Tyr Tyr Tyr 
625                 630                 635                 640 


Gly Ile Asp Arg Gly Gln Gln Glu Leu Ala Thr Leu Cys Val Val Arg 
                645                 650                 655     


Phe Ser Lys Glu His Tyr Glu Ala Met Leu Glu Asp Asn Phe Ile Lys 
            660                 665                 670         


Lys Phe Ser Lys Pro Ile Pro Ala Gln Ile Thr Ala Tyr Arg Ile Lys 
        675                 680                 685             


Asp Glu His Met Ser Tyr Arg Lys Asn Ile Thr Arg Asp Leu Lys Gly 
    690                 695                 700                 


Asn Glu Thr Glu Glu Ile Leu Phe Lys Asn Pro Ser His Phe Ile Asp 
705                 710                 715                 720 


Glu Val Glu Asn Phe Glu Glu Val Ser Thr Pro Cys Ile Asp Leu Thr 
                725                 730                 735     


Thr Ala Lys Leu Ile Lys Gly Lys Ile Ile Leu Asn Gly Asp Ile Gln 
            740                 745                 750         


Thr Tyr Leu Ala Leu Lys Lys Ala Asn Gly Lys Arg Gln Leu Phe Glu 
        755                 760                 765             


Lys Phe Ala Lys Ile Asp Asp Ser Ala Lys Ile Glu Phe Asp Asp Ser 
    770                 775                 780                 


Glu Gly Arg Phe Gln Val Lys Ser Lys Ala Thr Glu Arg Glu Glu Tyr 
785                 790                 795                 800 


Gln Phe Leu Pro Tyr Tyr Gly Pro Glu Gln Glu Asn Ile Ser Pro Arg 
                805                 810                 815     


Glu Asp Met Arg Arg Glu Leu Gln Ala Tyr Leu Asp Lys Leu Arg Ser 
            820                 825                 830         


Ser Glu Ser Phe Glu Glu Asp Ile Ser Ile Glu Lys Ile Asn His Leu 
        835                 840                 845             


Arg Asp Ala Ile Thr Ser Asn Met Val Gly Ile Ile Ala Phe Leu Phe 
    850                 855                 860                 


Thr Glu Tyr Pro Gly Ile Ile Asn Leu Glu Asn Leu His Ser Arg Glu 
865                 870                 875                 880 


Asn Ile Glu Lys Asn Trp Arg Lys Asn Asn Glu Asp Ile Ser Arg Arg 
                885                 890                 895     


Leu Glu Trp Gly Leu Tyr Lys Lys Phe Gln Lys Ile Gly Leu Val Pro 
            900                 905                 910         


Pro Arg Leu Arg Gln Thr Val Leu Leu Arg Glu Asn Glu Thr Glu Arg 
        915                 920                 925             


Gln Glu Lys Leu Asn Gln Phe Gly Ile Ile His Phe Ile Pro Thr Glu 
    930                 935                 940                 


Lys Thr Ser Ala Arg Cys Pro Tyr Cys Gly Glu Asn Thr Pro Met Lys 
945                 950                 955                 960 


Gln Arg Asn Glu Asp Lys Phe Lys Leu His Ala Tyr Ile Cys Arg Ser 
                965                 970                 975     


Asn Glu Glu Asn Cys Gly Phe Asp Thr Arg Glu Pro Lys Ser Pro Leu 
            980                 985                 990         


Glu Phe Ile Lys Asn Ser Asp Asp  Val Ala Ala Tyr Asn  Ile Ala Lys 
        995                 1000                 1005             


Lys Arg  Leu 
    1010     


<210>  8
<211>  1067
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.2İ

<400>  8

Met Lys Asn Gly Ile Asn Leu Phe Lys Thr Lys Thr Thr Lys Thr Lys 
1               5                   10                  15      


Gly Val Asp Met Glu Lys Tyr Gln Ile Thr Lys Thr Ile Arg Phe Lys 
            20                  25                  30          


Leu Leu Pro Asp Asn Ala His Glu Ile Val Glu Lys Val Lys Ser Leu 
        35                  40                  45              


Lys Thr Ser Asn Val Asp Glu Leu Met Asp Glu Val Lys Asn Val His 
    50                  55                  60                  


Leu Lys Gly Leu Glu Leu Leu Phe Ala Leu Lys Lys Tyr Phe Tyr Phe 
65                  70                  75                  80  


Asp Gly Asn Gln Cys Lys Ser Phe Lys Ser Thr Leu Glu Ile Lys Ala 
                85                  90                  95      


Arg Trp Leu Arg Leu Tyr Thr Pro Asp Gln Tyr Tyr Leu Lys Lys Ser 
            100                 105                 110         


Ser Lys Asn Ser Tyr Gln Leu Lys Ser Leu Ser Tyr Phe Lys Asp Val 
        115                 120                 125             


Phe Asn Asp Trp Leu Phe Asn Trp Glu Glu Ser Val Ser Glu Leu Ala 
    130                 135                 140                 


Ile Ile Tyr Glu Lys Tyr Lys Ile Cys Gln His Gln Arg Asp Ser Arg 
145                 150                 155                 160 


Ala Asp Ile Ala Leu Leu Ile Lys Lys Leu Ser Met Lys Glu Tyr Phe 
                165                 170                 175     


Pro Phe Ile Ser Asp Leu Ile Asp Cys Val Asn Asp Lys Asn Ser Asn 
            180                 185                 190         


Lys Thr Phe Leu Met Lys Leu Ser Glu Glu Leu Ser Val Leu Leu Glu 
        195                 200                 205             


Lys Cys Asn Ser Arg Ala Leu Pro Tyr Gln Ser Asn Gly Ile Val Val 
    210                 215                 220                 


Gly Lys Ala Ser Leu Asn Tyr Tyr Thr Val Ser Lys Ser Glu Lys Met 
225                 230                 235                 240 


Leu Gln Asn Glu Tyr Glu Asp Val Cys Gln Ser Leu Asp Lys Asn Tyr 
                245                 250                 255     


Asp Ile Thr Glu Met Lys Val Ile Leu Tyr Lys Glu Lys Leu Asp Asn 
            260                 265                 270         


Leu Asn Phe Lys Asp Val Thr Ile Ala Asn Ala Tyr Asn Leu Leu Lys 
        275                 280                 285             


Glu Asn Lys Ala Leu Gln Lys Arg Leu Phe Ser Glu Tyr Val Ser Gln 
    290                 295                 300                 


Gly Lys Val Leu Ser Leu Ile Lys Thr Glu Leu Pro Leu Phe Ser Asn 
305                 310                 315                 320 


Ile Asn Asp Asn Asp Phe Glu Lys Tyr Lys Glu Trp Ser Asn Glu Ile 
                325                 330                 335     


Lys Lys Leu Ala Asp Lys Lys Asn Thr Phe Cys Lys Lys Thr Gln Gln 
            340                 345                 350         


Asp Lys Ile Lys Asp Ile Gln Asn Lys Ile Ser Glu Leu Lys Lys Lys 
        355                 360                 365             


Arg Gly Ala Leu Phe Gln Tyr Lys Phe Thr Ser Phe Gln Lys His Cys 
    370                 375                 380                 


Asp Asn Tyr Lys Lys Val Ala Val Gln Tyr Gly Lys Leu Lys Ala Arg 
385                 390                 395                 400 


Lys Lys Ala Ile Glu Lys Asp Glu Ile Glu Ala Asn Leu Leu Arg Tyr 
                405                 410                 415     


Trp Ser Val Ile Leu Glu Gln Glu Asp Lys His Ser Leu Val Leu Ile 
            420                 425                 430         


Pro Lys Asn Asn Ala Lys Asp Ala Lys Gln Tyr Ile Glu Thr Ile Asn 
        435                 440                 445             


Thr Lys Gly Gly Lys Tyr Ile Ile His His Leu Asp Ser Leu Thr Leu 
    450                 455                 460                 


Arg Ala Leu Asn Lys Leu Cys Phe Asn Ala Val Asp Ile Glu Lys Gly 
465                 470                 475                 480 


Gln Met Val Arg Glu Asn Thr Phe Tyr Gln Gly Ile Lys Glu Glu Phe 
                485                 490                 495     


Glu Arg Asn Lys Ile Asn Cys Asp Asn Gln Gly Val Leu Lys Ile Gln 
            500                 505                 510         


Gly Leu Tyr Ser Phe Lys Thr Glu Gly Gly Gln Ile Asn Glu Lys Glu 
        515                 520                 525             


Ala Val Glu Phe Phe Lys Glu Val Leu Lys Ser Asn Tyr Ala Arg Glu 
    530                 535                 540                 


Val Leu Asn Leu Pro Tyr Asp Leu Glu Ser Asn Ile Phe Gln Lys Glu 
545                 550                 555                 560 


Tyr Thr Asn Leu Asp Gln Phe Arg Gln Asp Leu Glu Lys Cys Cys Tyr 
                565                 570                 575     


Ala Leu His Ser Lys Ile Gly Lys Asp Asp Leu Asp Glu Phe Thr Arg 
            580                 585                 590         


Arg Phe Glu Ala Gln Val Phe Asp Ile Thr Ser Ile Asp Leu Lys Ser 
        595                 600                 605             


Lys Lys Glu Lys Thr Lys Thr Thr Gly Glu Met Lys Lys His Thr Gln 
    610                 615                 620                 


Leu Trp Leu Glu Phe Trp Lys Gly Ala Ile Glu Gln Asn Phe Ala Thr 
625                 630                 635                 640 


Arg Val Asn Pro Glu Leu Ser Ile Phe Trp Arg Ala Pro Lys Ser Ser 
                645                 650                 655     


Arg Glu Lys Lys Tyr Gly Lys Gly Ser Asp Leu Tyr Asp Pro Asn Lys 
            660                 665                 670         


Asn Asn Arg Tyr Leu Tyr Glu Gln Tyr Thr Leu Ala Leu Thr Ile Thr 
        675                 680                 685             


Glu Asn Ala Gly Ser His Phe Lys Asp Ile Ala Phe Lys Asp Thr Ser 
    690                 695                 700                 


Lys Ile Lys Glu Ala Ile Lys Glu Phe Asn Met Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Lys Tyr Cys Phe Gly Ile Asp Arg Gly Asn Ala Glu Leu Val Ser Leu 
                725                 730                 735     


Cys Leu Ile Lys Asn Glu Lys Asp Phe Pro Phe Glu Lys Phe Pro Val 
            740                 745                 750         


Tyr Arg Leu Arg Asp Leu Thr Tyr Gln Gly Asp Phe Lys Asp Lys His 
        755                 760                 765             


Asp Gln Met Arg Tyr Gly Val Ala Ile Lys Asn Ile Ser Tyr Phe Ile 
    770                 775                 780                 


Asp Gln Glu Asp Leu Phe Glu Lys Asn Asn Leu Ser Ala Ile Asp Met 
785                 790                 795                 800 


Thr Thr Ala Lys Leu Ile Lys Asn Lys Ile Val Leu Asn Gly Asp Val 
                805                 810                 815     


Leu Thr Tyr Leu Lys Leu Lys Glu Glu Thr Ala Lys His Lys Leu Thr 
            820                 825                 830         


Gln Phe Phe Gln Gly Ser Ser Ile Asn Lys Asn Ser Arg Val Tyr Phe 
        835                 840                 845             


Asp Glu Asp Glu Asn Val Phe Lys Ile Thr Thr Asn Arg Asn His Asn 
    850                 855                 860                 


Pro Glu Glu Ile Ile Tyr Phe Tyr Arg Gly Glu Tyr Gly Ala Ile Lys 
865                 870                 875                 880 


Asn Lys Asn Asp Leu Glu Asp Ile Leu Asn Glu Tyr Leu Cys Lys Met 
                885                 890                 895     


Glu Thr Gly Glu Ser Glu Ile Val Leu Leu Asn Arg Val Asn His Leu 
            900                 905                 910         


Arg Asp Ala Ile Ser Ala Asn Ile Val Gly Ile Leu Ser Tyr Leu Ile 
        915                 920                 925             


Asp Leu Phe Pro Glu Thr Ile Val Ala Leu Glu Asn Leu Ala Lys Gly 
    930                 935                 940                 


Thr Ile Asp Arg His Val Ser Gln Ser Tyr Glu Asn Ile Thr Arg Arg 
945                 950                 955                 960 


Phe Glu Trp Ala Leu Tyr Arg Lys Leu Leu Asn Lys Gln Leu Ala Pro 
                965                 970                 975     


Pro Glu Leu Lys Glu Asn Ile Leu Leu Arg Glu Gly Asp Asp Lys Ile 
            980                 985                 990         


Asp Gln Phe Gly Ile Ile His Phe  Val Glu Glu Lys Asn  Thr Ser Lys 
        995                 1000                 1005             


Asp Cys  Pro Asn Cys Arg Lys  Thr Thr Gln Gln Thr  Asn Asp Asn 
    1010                 1015                 1020             


Lys Phe  Lys Glu Lys Lys Phe  Val Cys Lys Ser Cys  Gly Phe Asp 
    1025                 1030                 1035             


Thr Ser  Lys Asp Arg Lys Gly  Met Asp Ser Leu Asn  Ser Pro Asp 
    1040                 1045                 1050             


Thr Val  Ala Ala Tyr Asn Val  Ala Arg Lys Lys Phe  Glu Ser 
    1055                 1060                 1065         


<210>  9
<211>  1091
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.3İ

<400>  9

Met Ala Gly Thr Pro Tyr Thr Gly His Val Ala Cys Lys Tyr Cys Lys 
1               5                   10                  15      


Ile Thr Ser Trp Ala Thr Tyr Asp Arg Ile Lys Ile Asn Lys Ile Asn 
            20                  25                  30          


Met Asn Gln Ser Phe Ile Asn Gly Gln Asn Phe Tyr Glu Leu Arg Lys 
        35                  40                  45              


Thr Ile Arg Phe Val Leu Asp Pro Lys Thr Leu Lys Arg Pro Tyr Thr 
    50                  55                  60                  


Pro Ser Ser Asp Glu Val Asn Leu Glu Glu Gln Leu Asn Asn Phe Ile 
65                  70                  75                  80  


Glu Lys Tyr Gln Gln Gly Ile Asn Asp Phe Lys Tyr Ile Val Tyr Phe 
                85                  90                  95      


Gly Pro Lys Thr Ala Glu Thr Lys Glu Leu Asn Lys Lys Ile Ser Ile 
            100                 105                 110         


Lys His Ser Trp Leu Arg Asn Tyr Thr Lys Ser Glu Phe Tyr Ser Ile 
        115                 120                 125             


Lys Asp Lys Leu Ile Gln Leu Asp Tyr Asn Gly Asn Lys Ala Ser Ile 
    130                 135                 140                 


Gly Asn Ser Asn Leu Lys Phe Leu Asn Glu Tyr Phe Glu Asn Trp Ile 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Cys Ala Asp Ala Leu Lys Asn Cys Ile Asn Ala 
                165                 170                 175     


Pro Ala Glu Lys Gln Lys Arg Lys Ser Glu Ala Ala His Trp Val Arg 
            180                 185                 190         


Lys Leu Thr Lys Arg Ser Asn Phe Glu Cys Ile Phe Glu Leu Phe Asn 
        195                 200                 205             


Gly Asn Ile Asp His Lys Asn Ser Asn Asp Asp Ile Glu Lys Ile Lys 
    210                 215                 220                 


His Cys Leu Asn Glu Cys Lys Thr Leu Leu Thr Ser Leu Glu Lys Met 
225                 230                 235                 240 


Leu Leu Pro Ser Gln Ser Leu Gly Met Glu Ile Glu Arg Ala Ser Leu 
                245                 250                 255     


Asn Tyr Tyr Thr Ile Asn Lys Lys Pro Lys Asn Tyr Asp Glu Asp Ile 
            260                 265                 270         


Ala Gln Lys Ala Ser Ala Leu Asn Glu Ala Tyr Gln Phe Lys Ala Asp 
        275                 280                 285             


Asp Lys Ala Phe Leu Asn Arg Val Gly Phe Ser Asp Asp Gly Val Pro 
    290                 295                 300                 


Ile Asn Glu Leu Lys Glu Ala Met Lys Lys Phe Lys Ala Asp Gln Lys 
305                 310                 315                 320 


Ser Lys Phe Tyr Glu Phe Val Asn Gln Lys Lys Ser Tyr Ser Asp Leu 
                325                 330                 335     


Lys Lys Asn Asp Asp Leu Lys Leu Leu Asn Asp Ile Ser Glu Glu Asp 
            340                 345                 350         


Phe Asn Lys Phe Lys Glu Thr Gln Asp Lys Met Thr Arg Gly Lys His 
        355                 360                 365             


Phe Gln Phe Ser Phe Pro Asn Tyr Lys Lys Ser Glu Lys Asn Phe Cys 
    370                 375                 380                 


Asp Leu Tyr Lys Asn Val Ala Val Ala Phe Gly Lys Ile Arg Ala Asp 
385                 390                 395                 400 


Ile Lys Ala Leu Glu Lys Glu Arg Met Asp Ala Glu Lys Leu Gln Cys 
                405                 410                 415     


Trp Ala Val Ile Leu Glu Lys Asp Asn Gln Arg Tyr Val Val Thr Ile 
            420                 425                 430         


Pro Arg Asp Ala Asn Asn Asn Leu Thr Asn Thr Lys Gln Tyr Ile Asp 
        435                 440                 445             


Asn Leu Gln Asn Glu Glu Asn Asp Gln Trp Ile Leu Tyr Ala Phe Glu 
    450                 455                 460                 


Ser Leu Thr Leu Arg Ser Leu Asp Lys Leu Cys Phe Gly Leu Asp Lys 
465                 470                 475                 480 


Asn Thr Phe Ile Pro Ala Ile Thr Gly Glu Leu Tyr Gln Lys Asn Asn 
                485                 490                 495     


Ser Phe Phe Glu Lys Gly Leu Leu Lys Arg Lys Asp Gln Phe Ser Gln 
            500                 505                 510         


Asn Gly Thr Asp Leu Ala Ala Phe Tyr Lys Thr Val Leu Glu Leu Asp 
        515                 520                 525             


Ser Thr Lys Lys Met Leu Gly Ile Asn Lys Tyr Ala Asp Phe Lys Ala 
    530                 535                 540                 


Phe Ile Ser Lys Glu Tyr Thr Ala Leu Glu Asp Phe Glu Lys Thr Leu 
545                 550                 555                 560 


Lys Glu Thr Cys Tyr Phe Lys Lys Arg Val Phe Ile Ser Glu Asp Thr 
                565                 570                 575     


Lys Asn Lys Leu Ile Asn Asp Tyr Gln Gly Asn Leu Tyr Lys Ile Thr 
            580                 585                 590         


Ser Tyr Asp Leu Glu Lys Asp Asp Ser Glu Ala Leu Gly Thr Leu Ile 
        595                 600                 605             


Asn Lys Lys Gln Phe Asn Arg Ala Ser Pro Glu Ile His Thr Lys Thr 
    610                 615                 620                 


Trp Leu Asp Phe Trp Thr Ala Asp Asn Glu Thr Asp Lys Tyr Pro Ile 
625                 630                 635                 640 


Arg Leu Asn Pro Glu Phe Lys Ile Ser Phe Val Glu Lys Gln Asp Lys 
                645                 650                 655     


Asp Leu Asn Met Arg Asn Leu Gly Leu Leu Asn Lys Asn Arg Arg Leu 
            660                 665                 670         


Lys Ser Gln Phe Leu Leu Ser Thr Thr Ile Thr Leu Leu Ala His Glu 
        675                 680                 685             


Lys Asn Ala Asp Leu His Phe Lys Lys Thr Asp Glu Ile Gln Thr Phe 
    690                 695                 700                 


Ile Asn Ser Tyr Asn Gln Glu Phe Asn Lys Lys Ile Lys Pro Phe Asp 
705                 710                 715                 720 


Ile Tyr Tyr Tyr Gly Leu Asp Arg Gly Gln Lys Glu Leu Leu Thr Leu 
                725                 730                 735     


Gly Leu Phe Lys Phe Ser Glu Asn Glu Lys Val Ser Phe Thr Lys Gln 
            740                 745                 750         


Asp Gly Thr Val Gly Glu Tyr Ser Lys Pro Lys Phe Ile Pro Leu Asp 
        755                 760                 765             


Val Tyr Gln Ile Arg Glu Gly Gln Tyr Leu Thr Lys Asn Lys Lys Gly 
    770                 775                 780                 


Arg Leu Ala Tyr Lys Ser Ile Asp Gln Phe Ile Asp Asp Glu Lys Val 
785                 790                 795                 800 


Ile Glu Lys Leu Pro Val Asn Ser Cys Leu Asp Leu Ser Cys Ala Lys 
                805                 810                 815     


Leu Val Lys Gly Lys Ile Ile Gln Asn Gly Asp Val Ala Thr Tyr Leu 
            820                 825                 830         


Glu Leu Lys Arg Val Ser Ala Leu Arg Lys Ile Tyr Glu Asn Thr Thr 
        835                 840                 845             


Arg Gly Gln Phe Lys Thr Asp Arg Ile Gly Phe Asn Lys Asp Lys Gly 
    850                 855                 860                 


Cys Leu Phe Leu Asp Ile Glu Asn Arg Gly Lys Leu Glu Asn Asn Asn 
865                 870                 875                 880 


Leu Tyr Phe Tyr Asp Asn Arg Phe Ala Glu Ile Leu Ser Leu Asp Ser 
                885                 890                 895     


Ile Ile Lys Glu Leu Gln Asp Tyr Tyr Asn Glu Val Lys Asn Lys Gln 
            900                 905                 910         


Asn Ile Glu Phe Ile Ser Ile Asp Lys Ile Asn His Leu Arg Asp Ala 
        915                 920                 925             


Leu Cys Ala Asn Ala Val Gly Ile Leu Ala His Leu Gln Lys Thr His 
    930                 935                 940                 


Phe Gly Val Ile Val Phe Glu Gly Leu Asp Ala Arg His Lys Asn Lys 
945                 950                 955                 960 


Glu Thr Thr Glu Phe Ala Gly Asn Leu Ala Ser Arg Ile Glu Arg Lys 
                965                 970                 975     


Ile Leu Gln Lys Leu Glu Thr Leu Ser Leu Ile Pro Pro Gln His Arg 
            980                 985                 990         


Gln Ile Ile Asp Leu Gln Asn Ser  Lys Gln Ile Lys Gln  Thr Gly Ala 
        995                 1000                 1005             


Val Leu  Tyr Ile Glu Glu Lys  Gly Thr Ser Ala Asn  Cys Pro His 
    1010                 1015                 1020             


Cys Glu  Thr Ala Asn Pro Asp  Lys Ser Glu Lys Trp  Leu Ala His 
    1025                 1030                 1035             


Asn Tyr  Lys Cys Lys Asn Ser  Asn Cys Asn Phe Asp  Ala Ser Glu 
    1040                 1045                 1050             


Ile Ser  Lys Arg Lys Asp Leu  Ile Gly Leu Asp Asn  Ser Asp Ser 
    1055                 1060                 1065             


Val Ala  Thr Tyr Asn Ile Ala  Lys Arg Gly Leu Leu  Glu Met Asn 
    1070                 1075                 1080             


Gln Lys  Ile Glu Gln Ser Lys  Val 
    1085                 1090     


<210>  10
<211>  1057
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.4İ

<400>  10

Met Glu Ile Gln Glu Leu Lys Asn Leu Tyr Glu Val Lys Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ser Lys Lys Lys Ile Phe Glu Gly Gly Asp 
            20                  25                  30          


Val Ile Lys Leu Gln Lys Asp Phe Glu Lys Val Gln Lys Phe Phe Leu 
        35                  40                  45              


Asp Ile Phe Val Tyr Lys Asn Glu His Thr Lys Leu Glu Phe Lys Lys 
    50                  55                  60                  


Lys Arg Glu Ile Lys Tyr Thr Trp Leu Arg Thr Asn Thr Lys Asn Glu 
65                  70                  75                  80  


Phe Tyr Asn Trp Arg Gly Lys Ser Asp Thr Gly Lys Asn Tyr Ala Leu 
                85                  90                  95      


Asn Lys Ile Gly Phe Leu Ala Glu Glu Ile Leu Arg Trp Leu Asn Glu 
            100                 105                 110         


Trp Gln Glu Leu Thr Lys Ser Leu Lys Asp Leu Thr Gln Arg Glu Glu 
        115                 120                 125             


His Lys Gln Glu Arg Lys Ser Asp Ile Ala Phe Val Leu Arg Asn Phe 
    130                 135                 140                 


Leu Lys Arg Gln Asn Leu Pro Phe Ile Lys Asp Phe Phe Asn Ala Val 
145                 150                 155                 160 


Ile Asp Ile Gln Gly Lys Gln Gly Lys Glu Ser Asp Asp Lys Ile Arg 
                165                 170                 175     


Lys Phe Arg Glu Glu Ile Lys Glu Ile Glu Lys Asn Leu Asn Ala Cys 
            180                 185                 190         


Ser Arg Glu Tyr Leu Pro Thr Gln Ser Asn Gly Val Leu Leu Tyr Lys 
        195                 200                 205             


Ala Ser Phe Ser Tyr Tyr Thr Leu Asn Lys Thr Pro Lys Glu Tyr Glu 
    210                 215                 220                 


Asp Leu Lys Lys Glu Lys Glu Ser Glu Leu Ser Ser Val Leu Leu Lys 
225                 230                 235                 240 


Glu Ile Tyr Arg Arg Lys Arg Phe Asn Arg Thr Thr Asn Gln Lys Asp 
                245                 250                 255     


Thr Leu Phe Glu Cys Thr Ser Asp Trp Leu Val Lys Ile Lys Leu Gly 
            260                 265                 270         


Lys Asp Ile Tyr Glu Trp Thr Leu Asp Glu Ala Tyr Gln Lys Met Lys 
        275                 280                 285             


Ile Trp Lys Ala Asn Gln Lys Ser Asn Phe Ile Glu Ala Val Ala Gly 
    290                 295                 300                 


Asp Lys Leu Thr His Gln Asn Phe Arg Lys Gln Phe Pro Leu Phe Asp 
305                 310                 315                 320 


Ala Ser Asp Glu Asp Phe Glu Thr Phe Tyr Arg Leu Thr Lys Ala Leu 
                325                 330                 335     


Asp Lys Asn Pro Glu Asn Ala Lys Lys Ile Ala Gln Lys Arg Gly Lys 
            340                 345                 350         


Phe Phe Asn Ala Pro Asn Glu Thr Val Gln Thr Lys Asn Tyr His Glu 
        355                 360                 365             


Leu Cys Glu Leu Tyr Lys Arg Ile Ala Val Lys Arg Gly Lys Ile Ile 
    370                 375                 380                 


Ala Glu Ile Lys Gly Ile Glu Asn Glu Glu Val Gln Ser Gln Leu Leu 
385                 390                 395                 400 


Thr His Trp Ala Val Ile Ala Glu Glu Arg Asp Lys Lys Phe Ile Val 
                405                 410                 415     


Leu Ile Pro Arg Lys Asn Gly Gly Lys Leu Glu Asn His Lys Asn Ala 
            420                 425                 430         


His Ala Phe Leu Gln Glu Lys Asp Arg Lys Glu Pro Asn Asp Ile Lys 
        435                 440                 445             


Val Tyr His Phe Lys Ser Leu Thr Leu Arg Ser Leu Glu Lys Leu Cys 
    450                 455                 460                 


Phe Lys Glu Ala Lys Asn Thr Phe Ala Pro Glu Ile Lys Lys Glu Thr 
465                 470                 475                 480 


Asn Pro Lys Ile Trp Phe Pro Thr Tyr Lys Gln Glu Trp Asn Ser Thr 
                485                 490                 495     


Pro Glu Arg Leu Ile Lys Phe Tyr Lys Gln Val Leu Gln Ser Asn Tyr 
            500                 505                 510         


Ala Gln Thr Tyr Leu Asp Leu Val Asp Phe Gly Asn Leu Asn Thr Phe 
        515                 520                 525             


Leu Glu Thr His Phe Thr Thr Leu Glu Glu Phe Glu Ser Asp Leu Glu 
    530                 535                 540                 


Lys Thr Cys Tyr Thr Lys Val Pro Val Tyr Phe Ala Lys Lys Glu Leu 
545                 550                 555                 560 


Glu Thr Phe Ala Asp Glu Phe Glu Ala Glu Val Phe Glu Ile Thr Thr 
                565                 570                 575     


Arg Ser Ile Ser Thr Glu Ser Lys Arg Lys Glu Asn Ala His Ala Glu 
            580                 585                 590         


Ile Trp Arg Asp Phe Trp Ser Arg Glu Asn Glu Glu Glu Asn His Ile 
        595                 600                 605             


Thr Arg Leu Asn Pro Glu Val Ser Val Leu Tyr Arg Asp Glu Ile Lys 
    610                 615                 620                 


Glu Lys Ser Asn Thr Ser Arg Lys Asn Arg Lys Ser Asn Ala Asn Asn 
625                 630                 635                 640 


Arg Phe Ser Asp Pro Arg Phe Thr Leu Ala Thr Thr Ile Thr Leu Asn 
                645                 650                 655     


Ala Asp Lys Lys Lys Ser Asn Leu Ala Phe Lys Thr Val Glu Asp Ile 
            660                 665                 670         


Asn Ile His Ile Asp Asn Phe Asn Lys Lys Phe Ser Lys Asn Phe Ser 
        675                 680                 685             


Gly Glu Trp Val Tyr Gly Ile Asp Arg Gly Leu Lys Glu Leu Ala Thr 
    690                 695                 700                 


Leu Asn Val Val Lys Phe Ser Asp Val Lys Asn Val Phe Gly Val Ser 
705                 710                 715                 720 


Gln Pro Lys Glu Phe Ala Lys Ile Pro Ile Tyr Lys Leu Arg Asp Glu 
                725                 730                 735     


Lys Ala Ile Leu Lys Asp Glu Asn Gly Leu Ser Leu Lys Asn Ala Lys 
            740                 745                 750         


Gly Glu Ala Arg Lys Val Ile Asp Asn Ile Ser Asp Val Leu Glu Glu 
        755                 760                 765             


Gly Lys Glu Pro Asp Ser Thr Leu Phe Glu Lys Arg Glu Val Ser Ser 
    770                 775                 780                 


Ile Asp Leu Thr Arg Ala Lys Leu Ile Lys Gly His Ile Ile Ser Asn 
785                 790                 795                 800 


Gly Asp Gln Lys Thr Tyr Leu Lys Leu Lys Glu Thr Ser Ala Lys Arg 
                805                 810                 815     


Arg Ile Phe Glu Leu Phe Ser Thr Ala Lys Ile Asp Lys Ser Ser Gln 
            820                 825                 830         


Phe His Val Arg Lys Thr Ile Glu Leu Ser Gly Thr Lys Ile Tyr Trp 
        835                 840                 845             


Leu Cys Glu Trp Gln Arg Gln Asp Ser Trp Arg Thr Glu Lys Val Ser 
    850                 855                 860                 


Leu Arg Asn Thr Leu Lys Gly Tyr Leu Gln Asn Leu Asp Leu Lys Asn 
865                 870                 875                 880 


Arg Phe Glu Asn Ile Glu Thr Ile Glu Lys Ile Asn His Leu Arg Asp 
                885                 890                 895     


Ala Ile Thr Ala Asn Met Val Gly Ile Leu Ser His Leu Gln Asn Lys 
            900                 905                 910         


Leu Glu Met Gln Gly Val Ile Ala Leu Glu Asn Leu Asp Thr Val Arg 
        915                 920                 925             


Glu Gln Ser Asn Lys Lys Met Ile Asp Glu His Phe Glu Gln Ser Asn 
    930                 935                 940                 


Glu His Val Ser Arg Arg Leu Glu Trp Ala Leu Tyr Cys Lys Phe Ala 
945                 950                 955                 960 


Asn Thr Gly Glu Val Pro Pro Gln Ile Lys Glu Ser Ile Phe Leu Arg 
                965                 970                 975     


Asp Glu Phe Lys Val Cys Gln Ile Gly Ile Leu Asn Phe Ile Asp Val 
            980                 985                 990         


Lys Gly Thr Ser Ser Asn Cys Pro  Asn Cys Asp Gln Glu  Ser Arg Lys 
        995                 1000                 1005             


Thr Gly  Ser His Phe Ile Cys  Asn Phe Gln Asn Asn  Cys Ile Phe 
    1010                 1015                 1020             


Ser Ser  Lys Glu Asn Arg Asn  Leu Leu Glu Gln Asn  Leu His Asn 
    1025                 1030                 1035             


Ser Asp  Asp Val Ala Ala Phe  Asn Ile Ala Lys Arg  Gly Leu Glu 
    1040                 1045                 1050             


Ile Val  Lys Val 
    1055         


<210>  11
<211>  1158
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.5İ

<400>  11

Met Glu Asn Phe Lys Asn Leu Tyr Glu Val Arg Lys Thr Val Arg Phe 
1               5                   10                  15      


Glu Leu Lys Pro Ser Arg Lys Lys Thr Phe Ala Gly Gly Asp Ile Phe 
            20                  25                  30          


Glu Leu Gln Lys Asp Phe Glu Glu Val Gln Lys Phe Phe Leu Asp Ile 
        35                  40                  45              


Phe Val Phe Ala Ile Glu Gln Glu Lys Leu Tyr Gln Glu Glu Glu Glu 
    50                  55                  60                  


Glu Gly Lys Leu Ser Arg Tyr Thr Lys Ile Glu Phe Lys Lys Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Tyr Thr Trp Leu Arg Ile Tyr Thr Lys Asn Glu Phe Tyr 
                85                  90                  95      


Asp Trp Asn Gly Lys Asn Asp Lys Glu Lys Asn Tyr Ala Leu Ser Lys 
            100                 105                 110         


Ile Asp Phe Leu Glu Lys Glu Ile Leu Arg Trp Phe Asn Glu Trp Gln 
        115                 120                 125             


Glu Leu Thr Val Asn Leu Lys Asn Leu Thr Gln Thr Lys Glu His Glu 
    130                 135                 140                 


Lys Glu Arg Lys Ser Asp Ile Ala Phe Val Leu Arg Asn Phe Leu Lys 
145                 150                 155                 160 


Arg Gln Asn Phe Pro Phe Ile Lys Asp Phe Phe Asn Ala Val Ile Asp 
                165                 170                 175     


Ile Gln Glu Lys Gln Gly Asn Glu Ser Asp Glu Lys Ile Arg Lys Phe 
            180                 185                 190         


Arg Glu Glu Leu Arg Glu Met Lys Lys Asn Leu Asn Thr Cys Ala Lys 
        195                 200                 205             


Glu Tyr Leu Ser Ser Gln Ser Lys Gly Val Leu Leu His Lys Ala Ser 
    210                 215                 220                 


Phe Asn Tyr Tyr Thr Leu Asn Lys Thr Pro Lys Glu Tyr Glu Asn Leu 
225                 230                 235                 240 


Lys Leu Gln Lys Glu Leu Glu Ile Asp Asn Ile Leu Pro Lys Lys Ile 
                245                 250                 255     


Cys Lys Arg Val Arg Trp Asn Lys Glu Lys Lys Gln Glu Asp Ile Leu 
            260                 265                 270         


Phe Glu Cys Asn Ser Asp Trp Leu Val Glu Ile Lys Leu Gly Tyr Asp 
        275                 280                 285             


Ile Gln Lys Trp Thr Leu Asp Glu Ala Tyr Gln Lys Met Lys Thr Trp 
    290                 295                 300                 


Lys Ala Asp Gln Lys Ser Asp Phe Asn Glu Lys Ile Gly Asn Phe Ile 
305                 310                 315                 320 


Asp Gln Tyr Leu Lys Lys Gly Phe Ile Glu Asp Leu Met Asn Glu Asn 
                325                 330                 335     


Glu Lys Lys Asn Ala Glu Ala Ile Leu Arg Glu Phe Ser Val Phe Lys 
            340                 345                 350         


Pro Ile Glu Asn Phe Tyr Phe Tyr Asp Phe Leu Glu Arg Thr Lys Glu 
        355                 360                 365             


Ile Lys Ile Leu Ser Asn Gln Lys Asn Asn Ile Leu Gln Lys Tyr Asn 
    370                 375                 380                 


Lys Asn Ala Lys Tyr Phe Glu Lys Ile Ile Thr Tyr Lys Ile Lys Asp 
385                 390                 395                 400 


Lys Glu Asp Leu Thr Glu Asp Glu Lys Glu Tyr Gln Glu Leu Glu Lys 
                405                 410                 415     


Ser Ile Glu Lys Lys Ala Lys Glu Arg Gly Lys Phe Phe Asn Ala Pro 
            420                 425                 430         


Lys Glu Lys Val Gln Thr Gln His Tyr Phe Glu Leu Cys Glu Leu Tyr 
        435                 440                 445             


Lys Arg Ile Ala Met Lys Arg Gly Lys Ile Ile Ala Glu Ile Lys Gly 
    450                 455                 460                 


Ile Glu Asn Glu Glu Val Gln Ser Gln Leu Leu Thr His Trp Ala Leu 
465                 470                 475                 480 


Ile Ala Glu Glu Gly Glu Lys Lys Ser Val Val Phe Ile Pro Arg Lys 
                485                 490                 495     


Asn Gly Glu Glu Leu Glu Asn His Lys Lys Ala His Glu Phe Leu Gln 
            500                 505                 510         


Lys Gln Glu Lys Lys Glu Phe Gly Asp Ile Lys Ser Tyr His Phe Lys 
        515                 520                 525             


Ser Leu Thr Leu Arg Ala Leu Glu Lys Leu Cys Phe Lys Glu Thr Glu 
    530                 535                 540                 


Asn Thr Phe Thr Pro Glu Ile Lys Lys Glu Thr Asn Pro Lys Val Trp 
545                 550                 555                 560 


Phe Pro Lys Tyr Lys Gln Glu Trp Asn Asp Glu Pro Gln Lys Leu Ile 
                565                 570                 575     


Asn Phe Tyr Lys Gln Val Leu Gln Ser Lys Tyr Ser Gln Lys Tyr Leu 
            580                 585                 590         


Asp Leu Val Ala Phe Gly Asp Leu Lys Ser Phe Leu Glu Thr Ser Phe 
        595                 600                 605             


Asp Asp Leu Gln Ile Phe Glu Ser Gly Leu Glu Lys Thr Cys Tyr Ile 
    610                 615                 620                 


Lys Val Pro Ile Tyr Phe Ser Lys Glu Gly Phe Glu Thr Phe Thr Asn 
625                 630                 635                 640 


Arg Phe Asp Ala Glu Val Phe Glu Ile Thr Thr Arg Ser Ile Ser Ser 
                645                 650                 655     


Glu Ser Lys Arg Lys Glu Asn Ala His Ala Glu Ile Trp Lys Asp Phe 
            660                 665                 670         


Trp Ser Lys Glu Asn Glu Glu Lys Asn His Ile Thr Arg Leu Asn Pro 
        675                 680                 685             


Glu Val Ser Val Phe Tyr Arg Asp Glu Ile Glu Lys Lys Ser Asn Ala 
    690                 695                 700                 


Leu Arg Gly Asn Asn Lys Ser Asn Ile Asn Asn Arg Phe Ser Ala Ser 
705                 710                 715                 720 


Arg Phe Thr Leu Val Thr Thr Ile Thr Ile Arg Ala Thr His Lys Lys 
                725                 730                 735     


Ser Asn Leu Ala Phe Lys Thr Glu Glu Asp Ile Lys Ser His Ile Asp 
            740                 745                 750         


Lys Phe Asn Glu Ala Phe Gln Asn Phe Ser Gly Glu Trp Val Tyr Gly 
        755                 760                 765             


Ile Asp Arg Gly Leu Lys Glu Leu Ala Thr Leu Asn Val Val Lys Phe 
    770                 775                 780                 


Ser Asp Glu Lys Asn Glu Phe Gly Val Ile Lys Pro Lys Glu Phe Ala 
785                 790                 795                 800 


Lys Ile Pro Val Tyr Lys Leu Lys Asp Glu Lys Ala Ile Leu Lys Asp 
                805                 810                 815     


Glu Asn Gly Lys Asp Leu Lys Asn Ala Lys Gly Glu Ala Arg Lys Val 
            820                 825                 830         


Ile Asp Asn Ile Ser Glu Val Leu Glu Glu Lys Lys Glu Pro Asp Ser 
        835                 840                 845             


Asn Leu Phe Glu Lys Gln Gly Val Leu Ser Gln Gly Ile Ser Cys Ile 
    850                 855                 860                 


Asp Leu Thr Gln Ala Lys Leu Ile Lys Gly His Ile Ile Leu Asn Gly 
865                 870                 875                 880 


Asp Gln Lys Thr Tyr Leu Lys Leu Lys Glu Ile Ser Ala Lys Arg Arg 
                885                 890                 895     


Ile Phe Glu Leu Phe Ser Thr Ser Lys Ile Asp Lys Asn Ser Glu Leu 
            900                 905                 910         


Arg Val Glu Lys Thr Thr Ile Ser Ile Asn Ser Glu Asp Gly Lys Arg 
        915                 920                 925             


Asp Phe Tyr Trp Leu Thr Lys Asn Gln Ile Val Asn Ser Glu Thr Lys 
    930                 935                 940                 


Lys Glu Ile Gln Lys Glu Gln Gln Glu Lys Leu Asp Asn Leu Lys Val 
945                 950                 955                 960 


Ile Phe Ile Asp Tyr Leu Glu Gly Leu Cys Val Lys Asn Lys Phe Glu 
                965                 970                 975     


Asp Ile Glu Thr Ile Glu Lys Ile Asn His Leu Arg Asp Ala Ile Thr 
            980                 985                 990         


Ala Asn Met Val Gly Ile Leu Phe  His Leu Gln Lys Glu  Phe Lys Gly 
        995                 1000                 1005             


Ile Ile  Ala Leu Glu Asn Leu  Asp Thr Val Arg Glu  Gln Ser Asn 
    1010                 1015                 1020             


Lys Lys  Met Ile Asp Glu His  Phe Glu Gln Ser Asn  Glu Asp Ile 
    1025                 1030                 1035             


Ser Arg  Arg Leu Glu Trp Ala  Leu Tyr Arg Lys Phe  Ala Asn Met 
    1040                 1045                 1050             


Gly Glu  Val Pro Ser Gln Ile  Lys Glu Ser Ile Phe  Leu Arg Asp 
    1055                 1060                 1065             


Glu Phe  Lys Val Tyr Gln Met  Gly Leu Leu Lys Phe  Val Glu Val 
    1070                 1075                 1080             


Ser Gly  Thr Ser Ser Asn Cys  Pro Asn Cys Asp Lys  Glu Val Gly 
    1085                 1090                 1095             


Lys Thr  Asn Ser His Phe Val  Cys Lys Gly Glu Asn  Asn Cys Gly 
    1100                 1105                 1110             


Phe Ser  Ser Lys Glu Asn Arg  Asn Leu Leu Glu Gln  Asn Leu Asn 
    1115                 1120                 1125             


Asn Ser  Asp Glu Val Ala Ala  Tyr Asn Ile Ala Lys  Arg Gly Leu 
    1130                 1135                 1140             


Lys Leu  Ile Asn Gln Lys Trp  Asn Asn Thr Ser Lys  Ser Gln Asn 
    1145                 1150                 1155             


<210>  12
<211>  1064
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.6İ

<400>  12

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Leu Pro 
1               5                   10                  15      


Asp Lys Ile Gln Asp Ile Ser Arg Gln Val Ala Val Leu Gln Asn Ser 
            20                  25                  30          


Thr Asn Ala Glu Lys Lys Asn Asn Leu Leu Arg Leu Val Gln Arg Gly 
        35                  40                  45              


Gln Glu Leu Pro Lys Leu Leu Asn Glu Tyr Ile Arg Tyr Ser Asp Asn 
    50                  55                  60                  


His Lys Leu Lys Ser Asn Val Thr Val His Phe Arg Trp Leu Arg Leu 
65                  70                  75                  80  


Phe Thr Lys Asp Leu Phe Tyr Asn Trp Lys Lys Asp Asn Thr Glu Lys 
                85                  90                  95      


Lys Ile Lys Ile Ser Asp Val Val Tyr Leu Ser His Val Phe Glu Ala 
            100                 105                 110         


Phe Leu Lys Glu Trp Glu Ser Thr Ile Glu Arg Val Asn Ala Asp Cys 
        115                 120                 125             


Asn Lys Pro Glu Glu Ser Lys Thr Arg Asp Ala Glu Ile Ala Leu Ser 
    130                 135                 140                 


Ile Arg Lys Leu Gly Ile Lys His Gln Leu Pro Phe Ile Lys Gly Phe 
145                 150                 155                 160 


Val Asp Asn Ser Asn Asp Lys Asn Ser Glu Asp Thr Lys Ser Lys Leu 
                165                 170                 175     


Thr Ala Leu Leu Ser Glu Phe Glu Ala Val Leu Lys Ile Cys Glu Gln 
            180                 185                 190         


Asn Tyr Leu Pro Ser Gln Ser Ser Gly Ile Ala Ile Ala Lys Ala Ser 
        195                 200                 205             


Phe Asn Tyr Tyr Thr Ile Asn Lys Lys Gln Lys Asp Phe Glu Ala Glu 
    210                 215                 220                 


Ile Val Ala Leu Lys Lys Gln Leu His Ala Arg Tyr Gly Asn Lys Lys 
225                 230                 235                 240 


Tyr Asp Gln Leu Leu Arg Glu Leu Asn Leu Ile Pro Leu Lys Glu Leu 
                245                 250                 255     


Pro Leu Lys Glu Leu Pro Leu Ile Glu Phe Tyr Ser Glu Ile Lys Lys 
            260                 265                 270         


Arg Lys Ser Thr Lys Lys Ser Glu Phe Leu Glu Ala Val Ser Asn Gly 
        275                 280                 285             


Leu Val Phe Asp Asp Leu Lys Ser Lys Phe Pro Leu Phe Gln Thr Glu 
    290                 295                 300                 


Ser Asn Lys Tyr Asp Glu Tyr Leu Lys Leu Ser Asn Lys Ile Thr Gln 
305                 310                 315                 320 


Lys Ser Thr Ala Lys Ser Leu Leu Ser Lys Asp Ser Pro Glu Ala Gln 
                325                 330                 335     


Lys Leu Gln Thr Glu Ile Thr Lys Leu Lys Lys Asn Arg Gly Glu Tyr 
            340                 345                 350         


Phe Lys Lys Ala Phe Gly Lys Tyr Val Gln Leu Cys Glu Leu Tyr Lys 
        355                 360                 365             


Glu Ile Ala Gly Lys Arg Gly Lys Leu Lys Gly Gln Ile Lys Gly Ile 
    370                 375                 380                 


Glu Asn Glu Arg Ile Asp Ser Gln Arg Leu Gln Tyr Trp Ala Leu Val 
385                 390                 395                 400 


Leu Glu Asp Asn Leu Lys His Ser Leu Ile Leu Ile Pro Lys Glu Lys 
                405                 410                 415     


Thr Asn Glu Leu Tyr Arg Lys Val Trp Gly Ala Lys Asp Asp Gly Ala 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Thr Leu Tyr Tyr Phe Glu Ser Met Thr Tyr 
        435                 440                 445             


Arg Ala Leu Arg Lys Leu Cys Phe Gly Ile Asn Gly Asn Thr Phe Leu 
    450                 455                 460                 


Pro Glu Ile Gln Lys Glu Leu Pro Gln Tyr Asn Gln Lys Glu Phe Gly 
465                 470                 475                 480 


Glu Phe Cys Phe His Lys Ser Asn Asp Asp Lys Glu Ile Asp Glu Pro 
                485                 490                 495     


Lys Leu Ile Ser Phe Tyr Gln Ser Val Leu Lys Thr Asp Phe Val Lys 
            500                 505                 510         


Asn Thr Leu Ala Leu Pro Gln Ser Val Phe Asn Glu Val Ala Ile Gln 
        515                 520                 525             


Ser Phe Glu Thr Arg Gln Asp Phe Gln Ile Ala Leu Glu Lys Cys Cys 
    530                 535                 540                 


Tyr Ala Lys Lys Gln Ile Ile Ser Glu Ser Leu Lys Lys Glu Ile Leu 
545                 550                 555                 560 


Glu Asn Tyr Asn Thr Gln Ile Phe Lys Ile Thr Ser Leu Asp Leu Gln 
                565                 570                 575     


Arg Ser Glu Gln Lys Asn Leu Lys Gly His Thr Arg Ile Trp Asn Arg 
            580                 585                 590         


Phe Trp Thr Lys Gln Asn Glu Glu Ile Asn Tyr Asn Leu Arg Leu Asn 
        595                 600                 605             


Pro Glu Ile Ala Ile Val Trp Arg Lys Ala Lys Lys Thr Arg Ile Glu 
    610                 615                 620                 


Lys Tyr Gly Glu Arg Ser Val Leu Tyr Glu Pro Glu Lys Arg Asn Arg 
625                 630                 635                 640 


Tyr Leu His Glu Gln Tyr Thr Leu Cys Thr Thr Val Thr Asp Asn Ala 
                645                 650                 655     


Leu Asn Asn Glu Ile Thr Phe Ala Phe Glu Asp Thr Lys Lys Lys Gly 
            660                 665                 670         


Thr Glu Ile Val Lys Tyr Asn Glu Lys Ile Asn Gln Thr Leu Lys Lys 
        675                 680                 685             


Glu Phe Asn Lys Asn Gln Leu Trp Phe Tyr Gly Ile Asp Ala Gly Glu 
    690                 695                 700                 


Ile Glu Leu Ala Thr Leu Ala Leu Met Asn Lys Asp Lys Glu Pro Gln 
705                 710                 715                 720 


Leu Phe Thr Val Tyr Glu Leu Lys Lys Leu Asp Phe Phe Lys His Gly 
                725                 730                 735     


Tyr Ile Tyr Asn Lys Glu Arg Glu Leu Val Ile Arg Glu Lys Pro Tyr 
            740                 745                 750         


Lys Ala Ile Gln Asn Leu Ser Tyr Phe Leu Asn Glu Glu Leu Tyr Glu 
        755                 760                 765             


Lys Thr Phe Arg Asp Gly Lys Phe Asn Glu Thr Tyr Asn Glu Leu Phe 
    770                 775                 780                 


Lys Glu Lys His Val Ser Ala Ile Asp Leu Thr Thr Ala Lys Val Ile 
785                 790                 795                 800 


Asn Gly Lys Ile Ile Leu Asn Gly Asp Met Ile Thr Phe Leu Asn Leu 
                805                 810                 815     


Arg Ile Leu His Ala Gln Arg Lys Ile Tyr Glu Glu Leu Ile Glu Asn 
            820                 825                 830         


Pro His Ala Glu Leu Lys Glu Lys Asp Tyr Lys Leu Tyr Phe Glu Ile 
        835                 840                 845             


Glu Gly Lys Asp Lys Asp Ile Tyr Ile Ser Arg Leu Asp Phe Glu Tyr 
    850                 855                 860                 


Ile Lys Pro Tyr Gln Glu Ile Ser Asn Tyr Leu Phe Ala Tyr Phe Ala 
865                 870                 875                 880 


Ser Gln Gln Ile Asn Glu Ala Arg Glu Glu Glu Gln Ile Asn Gln Thr 
                885                 890                 895     


Lys Arg Ala Leu Ala Gly Asn Met Ile Gly Val Ile Tyr Tyr Leu Tyr 
            900                 905                 910         


Gln Lys Tyr Arg Gly Ile Ile Ser Ile Glu Asp Leu Lys Gln Thr Lys 
        915                 920                 925             


Val Glu Ser Asp Arg Asn Lys Phe Glu Gly Asn Ile Glu Arg Pro Leu 
    930                 935                 940                 


Glu Trp Ala Leu Tyr Arg Lys Phe Gln Gln Glu Gly Tyr Val Pro Pro 
945                 950                 955                 960 


Ile Ser Glu Leu Ile Lys Leu Arg Glu Leu Glu Lys Phe Pro Leu Lys 
                965                 970                 975     


Asp Val Lys Gln Pro Lys Tyr Glu Asn Ile Gln Gln Phe Gly Ile Ile 
            980                 985                 990         


Lys Phe Val Ser Pro Glu Glu Thr  Ser Thr Thr Cys Pro  Lys Cys Leu 
        995                 1000                 1005             


Arg Arg  Phe Lys Asp Tyr Asp  Lys Asn Lys Gln Glu  Gly Phe Cys 
    1010                 1015                 1020             


Lys Cys  Gln Cys Gly Phe Asp  Thr Arg Asn Asp Leu  Lys Gly Phe 
    1025                 1030                 1035             


Glu Gly  Leu Asn Asp Pro Asp  Lys Val Ala Ala Phe  Asn Ile Ala 
    1040                 1045                 1050             


Lys Arg  Gly Phe Glu Asp Leu  Gln Lys Tyr Lys 
    1055                 1060                 


<210>  13
<211>  1106
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.7İ

<400>  13

Met Leu Ile Gln Phe Lys Asn His Tyr Ser Tyr Asn Lys Ser Ile Arg 
1               5                   10                  15      


Phe Lys Leu Glu His Lys Asn Gly Lys Leu Pro Lys Leu Glu Ser Asp 
            20                  25                  30          


Asn Val Asp Leu Asn Lys Leu Val Asp Ile Gly Asn Ser Leu Lys Asp 
        35                  40                  45              


Ile Phe Glu Glu Leu Val Tyr Thr Lys Asn Asn Tyr Asn Lys Leu Asn 
    50                  55                  60                  


Ser Leu Val Ser Ile Lys Lys Gln Trp Leu Lys Ile Tyr Phe Lys Asn 
65                  70                  75                  80  


Glu Phe Tyr Ser Asn Gly Lys Ile Gln Asn Tyr Ser Leu Ser Asn Phe 
                85                  90                  95      


Ser Tyr Leu Pro Asn Lys Leu Ile Glu Trp Leu Asn Asn Trp Gln Asn 
            100                 105                 110         


Asn Leu Lys Ala Leu Ile Glu Leu Thr Lys Gln Gln Asp Phe Asn Lys 
        115                 120                 125             


Thr Lys Lys Ser Glu Ile Ala Tyr Ile Leu Ser Leu Phe Asn Gly Lys 
    130                 135                 140                 


Tyr Ser Phe Ser Phe Val Lys Asp Phe Ser Thr Cys Ile Asn His Lys 
145                 150                 155                 160 


Asn Ser Gln Glu Gln Ile Leu Lys Leu Gln Gly Val Val Glu Asn Phe 
                165                 170                 175     


Glu Lys Val Leu Asn Leu Cys Ile Gln Glu Tyr Leu Pro Ser Lys Ser 
            180                 185                 190         


Ala Gly Val Val Ile Ala Gln Gly Ser Met Asn Tyr Tyr Ala Ile Asn 
        195                 200                 205             


Lys Glu Pro Lys Arg Tyr Asp Asn Ile Leu Ala Asp Leu Asn Gln Lys 
    210                 215                 220                 


Phe Glu Glu Leu Asp Lys Glu Tyr Ile Ala Met Lys Gln Tyr Lys Ser 
225                 230                 235                 240 


Ser Gln Lys Ser Arg Leu Phe Glu Phe Ile Arg Lys Gly Phe Ser Lys 
                245                 250                 255     


Asp Gln Ile Leu Ser Glu Phe Lys Lys Lys Glu Asn Asn Glu Val Ser 
            260                 265                 270         


Phe Val Tyr Asn Asn Gln Ile Ile Ile Arg Ile Tyr Thr Gln Glu Leu 
        275                 280                 285             


Phe Lys Asp Ser Tyr Cys Leu Gly Glu Val Ile Lys Leu Thr Lys Lys 
    290                 295                 300                 


Ile Glu Glu Leu Asn Glu Ser Lys Asp Ser Asn Asn Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Thr Lys Lys Glu Ile Thr Lys Leu Lys Lys Glu Ile Gly Phe Tyr 
                325                 330                 335     


Phe Ile Arg Arg Thr Arg Gly Lys Ser His Asn Asn Tyr Phe Lys Ser 
            340                 345                 350         


Tyr Tyr Gly Phe Cys Asn Asp Lys Phe Lys Lys Lys Ala Gln Glu Arg 
        355                 360                 365             


Gly Arg Leu Leu Thr Lys Ile Lys Ala Ile Arg Lys Glu Lys Ile Glu 
    370                 375                 380                 


Ser Gln Asn Leu Arg Tyr Trp Ser Leu Ile Leu Asp Asp Gly Lys Asp 
385                 390                 395                 400 


Lys Phe Leu Trp Leu Val Pro Lys Glu Asn Met Gln Glu Phe Arg Arg 
                405                 410                 415     


Glu Leu Ser Lys Ile His Pro Ser Gly Glu Ser Ser Leu Phe Leu Phe 
            420                 425                 430         


His Ser Leu Thr Met Arg Ala Leu His Lys Leu Cys Phe Ala Gln Glu 
        435                 440                 445             


Ser Asp Phe Val Lys Glu Met Pro Lys Val Leu Lys Glu Glu Gln Leu 
    450                 455                 460                 


Asn Cys Glu Lys Ala Ser Asn Asp Thr Glu Thr Asn Lys Arg Ile Lys 
465                 470                 475                 480 


Arg Asn Phe Gly Leu Asn Tyr Ile Lys Thr Lys Asp Glu Leu Thr Leu 
                485                 490                 495     


Ser Phe Leu Lys Lys Leu Ile Ile Ser Glu Tyr Ala His Glu Arg Leu 
            500                 505                 510         


Asp Leu Asn His Phe Asp Leu Ser Lys Leu Gln Val Ala Thr Thr Leu 
        515                 520                 525             


Asn Glu Phe Glu Glu Tyr Leu Glu Asp Ala Cys Tyr Tyr Leu Glu Lys 
    530                 535                 540                 


Ile Ser Ile Ser Ser Ser Met Ile Lys Glu Leu Leu Glu Glu Tyr Asn 
545                 550                 555                 560 


Ile Leu Asn Phe Arg Ile Thr Ser Tyr Asp Leu Glu Lys Arg Asn Lys 
                565                 570                 575     


Asn Thr Tyr Gln Thr Pro Glu Ser Asp Ile Lys Arg His Thr Lys Glu 
            580                 585                 590         


Ile Trp Asn Lys Phe Trp Glu Gly Asp Arg Phe Ile Arg Leu Asn Pro 
        595                 600                 605             


Glu Ile Lys Ile Arg Tyr Arg Gln Lys Asn Gln Asn Ile Glu Asp Tyr 
    610                 615                 620                 


Leu Lys Glu Lys Gly Phe Asp Leu Thr Lys Ile Lys Asn Arg Phe Leu 
625                 630                 635                 640 


Gln Glu Gln Tyr Ser Val Ser Phe Thr Phe Ala Leu Asn Ala Gly Lys 
                645                 650                 655     


Lys Tyr Pro Lys Leu Ala Phe Val Lys Thr Glu Glu Ile Leu Glu Lys 
            660                 665                 670         


Ile Glu Glu Phe Asn Asp Glu Phe Asn Lys Gln Tyr Phe Asp Asn Ser 
        675                 680                 685             


Tyr Lys Tyr Gly Ile Asp Arg Gly Asn Ile Glu Leu Ala Thr Leu Cys 
    690                 695                 700                 


Ile Thr Lys Phe Asn Lys Asn Asp Thr Tyr Glu Tyr Lys Gly Lys Lys 
705                 710                 715                 720 


Tyr Leu Lys Pro Asn Phe Pro Thr Ser Gln Glu Asp Ile Lys Thr Tyr 
                725                 730                 735     


Glu Leu Lys Asn Glu Trp Tyr Lys Arg Thr Ala Ile Ser Asn Ile Glu 
            740                 745                 750         


Thr Lys Pro Lys Asn Lys Lys Thr Pro Lys Arg Ile Ile Ala Asn Ile 
        755                 760                 765             


Ser Tyr Phe Ile Asp Asn Val Glu Asn Glu Glu Trp Phe Asn Lys Lys 
    770                 775                 780                 


Thr Cys Thr Ser Ile Asp Leu Thr Thr Ala Lys Val Ile Lys Gly Lys 
785                 790                 795                 800 


Leu Ile Leu Asn Gly Asp Val Leu Thr Phe Leu Lys Leu Lys Lys Glu 
                805                 810                 815     


Ala Ala Lys Arg Ile Leu Phe Glu Leu Val Ala Gln Asn Lys Leu Thr 
            820                 825                 830         


Ala Lys Asn Lys Glu Leu Lys Trp Lys Ser Asp Asp Gly Asn Asn Ser 
        835                 840                 845             


Asp Ser Val Arg Leu Ile Cys Asp Val Leu Asp Asn Glu Thr Asn Ser 
    850                 855                 860                 


Ile Tyr Phe Tyr Glu Asp Ser Lys Tyr Gly Arg Gly Phe Glu Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Asp Lys Thr Ala Tyr Ser Lys Glu Gly Ile Arg Ile Asn 
                885                 890                 895     


Leu Gln Asn Tyr Leu Asn His Leu Ile Ser Glu Lys Glu Asn Lys Ser 
            900                 905                 910         


Asn Lys Ala Tyr Ser His Val Pro Ser Ile Glu Lys Ile Asn His Leu 
        915                 920                 925             


Arg Asp Ala Leu Val Ala Asn Met Val Gly Val Ile Ser Tyr Leu Gln 
    930                 935                 940                 


Ala Tyr Tyr Pro Gly Ile Val Val Leu Glu Asp Leu Asn His Lys Leu 
945                 950                 955                 960 


Leu Ile Lys His Phe Glu Asp Leu Asn Ile Asn Ile Ser Asn Arg Phe 
                965                 970                 975     


Glu His Ala Leu Ile Glu Lys Phe Gln Thr Leu Gly Met Val Pro Pro 
            980                 985                 990         


His Ile Lys Asp Tyr Leu Glu Ile  Arg Ser Ser Phe Arg  Met Ser Arg 
        995                 1000                 1005             


Asn Asp  Ser Ser Gln Phe Gly  Ala Leu Ile Phe Val  Ser Lys Glu 
    1010                 1015                 1020             


Gly Thr  Ser Lys Glu Cys Pro  Tyr Cys Glu Lys Lys  Trp Asn Trp 
    1025                 1030                 1035             


Gly Lys  Glu Lys Glu Ile Glu  Leu Lys Phe Ser Lys  Lys Gln Tyr 
    1040                 1045                 1050             


Ile Cys  Gly Lys Glu Asn Ser  Cys Gly Phe Asp Thr  Lys His Ile 
    1055                 1060                 1065             


Gln Asn  Thr Phe Glu Phe Leu  Ser Glu Ile Asn Asp  Pro Asp Lys 
    1070                 1075                 1080             


Ile Ala  Ala Tyr Asn Ile Ala  Lys Arg Gly Phe Lys  Ser Phe Ile 
    1085                 1090                 1095             


Asn Lys  Ser Ser Ile Lys Lys  Gln 
    1100                 1105     


<210>  14
<211>  1085
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.8İ

<400>  14

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Leu Pro 
1               5                   10                  15      


Asp Lys Ile Gln Asp Ile Ser Arg Gln Val Ala Val Leu Gln Asn Ser 
            20                  25                  30          


Thr Asn Ala Glu Lys Lys Asn Asn Leu Leu Arg Leu Ile Gln Arg Gly 
        35                  40                  45              


Gln Glu Leu Pro Lys Leu Leu Asn Glu Tyr Ile Arg Tyr Ser Asp Asn 
    50                  55                  60                  


His Lys Leu Lys Ser Asn Val Thr Val His Phe Arg Trp Leu Arg Leu 
65                  70                  75                  80  


Phe Thr Lys Asp Leu Phe Tyr Asn Trp Lys Lys Asp Asn Thr Glu Lys 
                85                  90                  95      


Lys Ile Lys Ile Ser Asp Val Asp Tyr Leu Ser Arg Val Phe Glu Asp 
            100                 105                 110         


Phe Phe Asn Glu Trp Glu Thr Val Ile Glu Arg Ile Asn Thr Asp Cys 
        115                 120                 125             


Asn Arg Pro Glu Glu Ser Lys Thr Arg Asp Ala Glu Ile Ala Phe Ser 
    130                 135                 140                 


Ile Lys Lys Ile Ala Thr Lys Gln Met Phe Pro Phe Ile Lys Ser Phe 
145                 150                 155                 160 


Val Tyr Asn Ser Asn Tyr Lys Asn Ser Glu Glu Thr Lys Ser Lys Leu 
                165                 170                 175     


Thr Ala Leu Leu Asn Glu Phe Glu Thr Val Leu Lys Ile Cys Glu Gln 
            180                 185                 190         


Asn Tyr Leu Pro Ser Gln Ser Ala Gly Ile Val Ile Ala Lys Ala Ser 
        195                 200                 205             


Phe Asn Tyr Tyr Thr Ile Asn Lys Lys Gln Lys Asp Tyr Lys Gly Tyr 
    210                 215                 220                 


Thr Asp Asp Ile Glu Lys Ile Glu Lys Gly Met Asn Ser Lys Phe His 
225                 230                 235                 240 


Tyr Glu Arg Lys Tyr Asp Gln Leu Leu Glu Glu Leu Asn Leu Ile Ala 
                245                 250                 255     


Leu Lys Glu Leu Pro Leu Ile Glu Phe Tyr Ser Lys Ile Lys Ser Tyr 
            260                 265                 270         


Lys Ser Thr Arg Lys Ile Glu Phe Ser Glu Ala Val Ser Lys Gly Leu 
        275                 280                 285             


Ala Phe Ala Asp Leu Lys Ser Lys Phe Pro Leu Phe Gln Thr Glu Ser 
    290                 295                 300                 


Asn Lys Tyr Ala Glu Phe Leu Glu Leu Thr Gly Arg Ile Thr Gln Ile 
305                 310                 315                 320 


Ser Thr Ala Lys Ser Leu Leu Ser Lys Asp Asn Pro Glu Ala Gln Lys 
                325                 330                 335     


Leu Arg Asp Glu Ile Lys Lys Leu Arg Ile Asn Arg Gly Glu Tyr Phe 
            340                 345                 350         


Lys Asn Asn Phe His Lys Tyr Ile Ser Leu Cys Asn Leu Tyr Lys Lys 
        355                 360                 365             


Ile Ala Asp Lys Lys Gly Arg Leu Lys Gly Gln Val Lys Gly Ile Glu 
    370                 375                 380                 


Asn Glu Arg Ile Asp Ser Gln Arg Ile Gln His Trp Ala Leu Val Leu 
385                 390                 395                 400 


Glu Asp Asn Leu Lys His Ser Leu Ile Leu Ile Pro Lys Glu Lys Val 
                405                 410                 415     


Thr Glu Val Tyr Arg Lys Val Arg Ala Ser Lys Ala Asp Ser Thr Ser 
            420                 425                 430         


Ser Ser Ser Ser Leu Tyr Tyr Phe Glu Ser Met Thr Tyr Arg Ala Leu 
        435                 440                 445             


His Lys Leu Cys Phe Gly Val Asn Gly Asn Thr Phe Leu Pro Glu Ile 
    450                 455                 460                 


Gln Lys Glu Leu Pro Glu Tyr Asn Pro Asn Lys Gln Ser Asp Phe Gly 
465                 470                 475                 480 


Glu Phe Cys Phe His Lys Ser Asn Thr Asp Lys Glu Ile Asp Glu Pro 
                485                 490                 495     


Lys Leu Ile Ser Phe Tyr Gln Ser Val Leu Lys Thr Asn Tyr Val Lys 
            500                 505                 510         


Asp Asn Leu Asn Leu Pro Gln Ser Val Phe Asp Glu Ala Thr Val Gln 
        515                 520                 525             


Thr Phe Glu Thr Arg Gln Asp Phe Gln Ile Ala Leu Glu Lys Cys Cys 
    530                 535                 540                 


Tyr Ala Lys Lys Thr Ile Ile Ser Glu Thr Leu Lys Lys Glu Ile Leu 
545                 550                 555                 560 


Glu Asp Asn Asn Val Gln Ile Phe Gln Ile Thr Ser Leu Asp Leu Gln 
                565                 570                 575     


Arg Ser Glu Gln Lys Asn Leu Lys Ala His Thr Lys Ile Trp Asn Arg 
            580                 585                 590         


Phe Trp Thr Lys Gln Asn Glu Thr Ala Asn Tyr Asp Leu Arg Leu Asn 
        595                 600                 605             


Pro Glu Thr Ala Ile Val Trp Arg Lys Pro Lys Lys Thr Arg Ile Asp 
    610                 615                 620                 


Lys Tyr Gly Ala Gly Thr Ser Leu Tyr Asp Pro Lys Lys Arg Asn Arg 
625                 630                 635                 640 


Tyr Leu His Glu Gln Tyr Thr Leu Cys Thr Thr Val Thr Asp Asn Ala 
                645                 650                 655     


Leu Asn Asn Glu Ile Thr Phe Ala Phe Glu Asp Thr Lys Lys Lys Gly 
            660                 665                 670         


Thr Glu Ile Val Lys Tyr Asn Glu Lys Ile Asn Gln Thr Leu Lys Lys 
        675                 680                 685             


Glu Phe Asn Lys Asn Gln Leu Trp Phe Tyr Gly Ile Asp Ala Gly Glu 
    690                 695                 700                 


Ile Glu Leu Ala Thr Leu Ala Leu Met Asn Lys Asp Lys Glu Pro Gln 
705                 710                 715                 720 


Leu Phe Thr Val Tyr Glu Leu Lys Lys Ser Asp Phe Phe Lys His Gly 
                725                 730                 735     


Tyr Ile Tyr Asn Lys Glu Arg Glu Leu Val Ile Arg Glu Lys Pro Tyr 
            740                 745                 750         


Lys Ala Ile Gln Asn Leu Ser Tyr Phe Leu Asn Glu Glu Leu Tyr Glu 
        755                 760                 765             


Lys Thr Phe Arg Asp Gly Lys Phe Gln Glu Thr Phe Asn Glu Leu Phe 
    770                 775                 780                 


Lys Glu Lys His Val Ser Ala Ile Asp Leu Thr Thr Ala Lys Val Ile 
785                 790                 795                 800 


Asn Gly Lys Ile Ile Leu Asn Gly Asp Met Ile Thr Phe Leu Asn Leu 
                805                 810                 815     


Arg Ile Leu His Ala Lys Arg Lys Ile Tyr Glu Glu Leu Ile Ile Asn 
            820                 825                 830         


Pro Gln Ala Glu Leu Lys Glu Asn Glu Lys Glu Tyr Tyr Leu Tyr Phe 
        835                 840                 845             


Asp Lys Glu Gly Thr Glu Lys Val Glu Lys Ile Tyr Arg Ser Arg Leu 
    850                 855                 860                 


Asp Phe Glu His Ile Lys Pro Tyr Gln Glu Ile Arg Asn Asp Leu Asn 
865                 870                 875                 880 


Ala Tyr Phe Lys Asn Val Gln Lys Asn Glu Ala Lys Val Glu Asp Gln 
                885                 890                 895     


Ile Asn Gln Thr Arg Arg Ala Leu Val Gly Asn Met Ile Gly Val Ile 
            900                 905                 910         


Tyr Tyr Leu Tyr Gln Lys Tyr Arg Gly Ile Ile Ser Ile Glu Asp Leu 
        915                 920                 925             


Lys Gln Thr Lys Val Glu Ser Asp Arg Asn Lys Phe Glu Gly Asn Ile 
    930                 935                 940                 


Glu Arg Pro Leu Glu Trp Ala Leu Tyr Arg Lys Phe Gln Gln Glu Gly 
945                 950                 955                 960 


Tyr Val Pro Pro Ile Ser Glu Leu Ile Lys Leu Arg Glu Leu Glu Lys 
                965                 970                 975     


Phe Pro Leu Lys Asp Val Lys Gln Pro Lys Tyr Glu Asn Ile Gln Gln 
            980                 985                 990         


Phe Gly Ile Ile Lys Phe Val Ser  Pro Glu Glu Thr Ser  Thr Thr Cys 
        995                 1000                 1005             


Pro Ser  Cys Glu Lys Lys Ala  Tyr Glu Leu Gln Lys  Glu Lys Lys 
    1010                 1015                 1020             


Gly Glu  Glu Lys Pro Ala Glu  Asn Lys Arg Tyr Glu  Ala Asp Lys 
    1025                 1030                 1035             


Lys Ala  Gly Val Phe Cys Cys  Pro Lys Cys Gly Phe  His Asn Arg 
    1040                 1045                 1050             


Thr Asn  Pro Met Gly Tyr Glu  Ser Leu Asp Ser Asn  Asp Lys Val 
    1055                 1060                 1065             


Ala Ala  Phe Asn Ile Ala Lys  Arg Gly Phe Glu Asp  Leu Gln Lys 
    1070                 1075                 1080             


His Lys  
    1085 


<210>  15
<211>  1033
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.9İ

<400>  15

Met Glu Asn Ser Asn Leu Tyr Gln Val Val Lys Thr Ile Arg Phe Lys 
1               5                   10                  15      


Leu Glu Pro Val Gly Lys Met Asp Thr Pro Lys Phe Gly Asp Lys Asn 
            20                  25                  30          


Ala Glu Ser Lys Ala Asn Leu Thr Pro Phe Ile Glu Leu Val Lys Lys 
        35                  40                  45              


Thr Met Thr Asn Val Lys Ala Leu Val Phe Ser Lys Gln Asp Gly Glu 
    50                  55                  60                  


Asp Gly Glu Lys Trp Arg Lys Ile Leu Glu Val Asn Tyr Arg Phe Leu 
65                  70                  75                  80  


Arg Ser Tyr Leu Lys Asn Ser Phe Tyr Glu Asn Arg Gly Asp Ser Gln 
                85                  90                  95      


Glu Lys Ser Lys Lys His Lys Ile Ser Asp Leu Glu Tyr Leu Gln Lys 
            100                 105                 110         


Ala Leu Glu Asn Leu Phe Ala Glu Phe Asp Glu Ile Leu Asp Gly Leu 
        115                 120                 125             


Glu Asp Phe Glu Lys Arg Asn Thr Lys Asn Gln Tyr Glu Lys Gln Arg 
    130                 135                 140                 


His Ala Gln Ala Gly Leu Leu Leu Asn Arg Leu Cys Lys Arg Ser Asn 
145                 150                 155                 160 


Phe Gly Phe Leu Lys Ala Phe Val Gly Ala Leu Ala Gln Thr Asn Lys 
                165                 170                 175     


Pro Phe Phe Asp Asp Lys Thr Asp Lys Leu Lys Lys Gln Ile Asp Lys 
            180                 185                 190         


Phe Glu Thr Glu Leu Glu Lys Gln Lys Glu Phe Phe Leu Pro Tyr Gln 
        195                 200                 205             


Ser Asn Gly Val Leu Phe Ala Gly Gly Ser Phe Asn Arg Tyr Ala Ile 
    210                 215                 220                 


Asn Lys Thr Pro Lys Met Leu Asp Lys Glu Leu Arg Glu Glu Gln Thr 
225                 230                 235                 240 


Asn Leu Lys Lys Ser Leu Cys Glu His Lys Ile Lys Ile Asp Thr Leu 
                245                 250                 255     


Asn Thr Leu Gly Leu Lys Asn Asp Cys Pro Cys Thr Ser Leu Asp Asn 
            260                 265                 270         


Ser Tyr Thr Phe Ile Lys Asp Tyr Lys Ala Lys Gln Lys Ser Lys Phe 
        275                 280                 285             


Ile Glu Leu Val Gln Lys Gly Glu Phe Asp Glu Ala Lys Lys Val Asn 
    290                 295                 300                 


Leu Phe Glu Cys Ser Glu Thr Asp Phe Glu Thr Phe Lys Thr Arg Thr 
305                 310                 315                 320 


Lys Gln Ile Gln Asn Glu Lys Asp Lys Asp Glu Arg Thr Lys Leu Lys 
                325                 330                 335     


Gln Lys Arg Gly Glu Phe Phe Lys Ser Gln Lys Arg Gly Lys Phe Phe 
            340                 345                 350         


Lys Ser Gln Thr Gln Asn Tyr Glu Asn Leu Cys Asp Leu Tyr Lys Lys 
        355                 360                 365             


Ile Ala Gln Lys Arg Gly Gln Ile Val Ala Lys Ile Cys Ala Ile Lys 
    370                 375                 380                 


Lys Glu Lys Glu Met Cys Glu Gln Val Lys Tyr Trp Cys Val Ala Leu 
385                 390                 395                 400 


Glu Lys Gly Gly Glu Phe Tyr Leu Tyr Met Phe Leu Arg Asp Glu Asn 
                405                 410                 415     


Asp Asn Ile Lys Asn Ala Tyr Asp Phe Val Ser Lys Leu Gln Thr Gln 
            420                 425                 430         


Lys Ser Gly Glu Thr Lys Leu His Tyr Phe Asp Ser Leu Thr Leu Lys 
        435                 440                 445             


Ala Val Arg Lys Leu Cys Phe Lys Glu Thr Asp Gly Ser Phe Lys Lys 
    450                 455                 460                 


Ala Leu Lys Asn Val Lys Phe Pro Glu Cys Glu Gln Asn Leu Asp Glu 
465                 470                 475                 480 


Lys Val Lys Ile Ser Phe Tyr Gln Asn Val Leu Lys Asn Ala Lys Thr 
                485                 490                 495     


Leu Asn Leu Ser Lys Phe Glu Asn Leu Gln Ser Val Thr Glu Gly Lys 
            500                 505                 510         


Phe Glu Ser Leu Ser Glu Phe Glu Val Ala Leu Asn Met Val Cys Tyr 
        515                 520                 525             


Thr Lys Thr Val Cys Val Ser Glu Ser Val Glu Lys Glu Leu Lys Lys 
    530                 535                 540                 


Phe Lys Pro Leu Val Phe His Ile Thr Ser Gln Asp Leu Ala Ala Lys 
545                 550                 555                 560 


Arg Glu Lys Lys Ala His Thr Gln Ile Trp His Glu Phe Trp Arg Glu 
                565                 570                 575     


Ser Asn Glu Lys Ser Lys Phe Pro Leu Arg Leu Asn Pro Glu Leu Lys 
            580                 585                 590         


Val Met Trp Arg Glu Ala Arg Pro Ser Arg Val Glu Lys Tyr Ala Glu 
        595                 600                 605             


Gln Ser Asp Lys Phe Asp Pro Asn Lys Lys Asn Arg Tyr Leu His Pro 
    610                 615                 620                 


Gln Phe Thr Leu Ala Leu Asn Phe Thr Gln Asn Ala His Asn Glu Ala 
625                 630                 635                 640 


Ile Asn Leu Ala Phe Lys Asp Val Gln Asn Lys Gly Glu Ala Val Lys 
                645                 650                 655     


Lys Phe Asn Glu Asn Phe Lys Ser Ser Glu Tyr Ala Phe Gly Ile Asp 
            660                 665                 670         


Val Gly Thr Lys Asp Leu Ala Leu Leu Cys Leu Ile Asp Lys Asn Lys 
        675                 680                 685             


Lys Pro Val Asn Phe Asp Val Tyr Glu Ile Cys Asn Glu Asn Glu Ile 
    690                 695                 700                 


Cys Asn Glu Lys Leu Gly Phe Glu Lys Phe Gly Phe Tyr Lys Asp Gly 
705                 710                 715                 720 


Thr Arg Arg Asp Glu Pro Tyr Lys Leu Ile Lys Asn Pro Ser Tyr Phe 
                725                 730                 735     


Leu Asn Glu Ser Leu Tyr Lys Lys Thr Phe Asn Ala Thr Lys Glu Glu 
            740                 745                 750         


Phe Glu Arg Ser Phe Ser Glu Leu Phe Lys Arg Lys Ser Val Cys Ala 
        755                 760                 765             


Leu Asp Leu Thr Thr Ala Lys Val Ile Cys Gly Lys Ile Ile Leu Asn 
    770                 775                 780                 


Gly Asp Phe Ser Thr His Leu Asn Leu Lys Ile Leu Asn Ala Lys Arg 
785                 790                 795                 800 


Lys Ile Ser Ala Lys Leu Lys Lys Asp Pro Thr Leu Lys Ile Glu Tyr 
                805                 810                 815     


Asp Asn Asp Asp Asn Ile Leu Phe Gly Ser Asn Val Ile Phe Tyr Tyr 
            820                 825                 830         


Asn Asn Lys Tyr Glu Ile Val Arg Pro Tyr Asp Glu Ile Lys Asn Glu 
        835                 840                 845             


Ile Phe Glu Phe His Glu Lys Gln Arg Leu Asp Asp Ala Arg Leu Glu 
    850                 855                 860                 


Asp Asn Ile Asn Lys Thr Arg Ala Asn Leu Val Ala Asn Met Val Gly 
865                 870                 875                 880 


Val Ile Ser Phe Leu His Lys Glu Phe Ser Gly Phe Val Val Leu Glu 
                885                 890                 895     


Asn Leu Lys Gln Ser Glu Ile Glu Gly Asn His Arg Leu Lys Phe Glu 
            900                 905                 910         


Gly Asp Ile Thr Arg Pro Leu Glu Leu Ala Leu Tyr Arg Lys Phe Gln 
        915                 920                 925             


Ser Lys Cys Leu Thr Pro Pro Ile Ser Glu Leu Ile Lys Leu Arg Glu 
    930                 935                 940                 


Gly Glu Lys Asn Glu Asn Val Glu Ser Asp Leu Ile Leu Gln Phe Gly 
945                 950                 955                 960 


Ile Ile Lys Phe Val Asp Lys Asp Lys Thr Ser Arg Leu Cys Pro Ala 
                965                 970                 975     


Cys Gly Lys Asp Ala Tyr Glu Asn Asn Asn Ser Lys Tyr Lys Thr Asp 
            980                 985                 990         


Lys Lys Asp Gly Val Phe Glu Cys  Ala Gly Cys Gly Phe  Asn Asn Lys 
        995                 1000                 1005             


Asn Asn  Ala Gly Asp Phe Ala  Ala Leu Asp Thr Asn  Asp Lys Ile 
    1010                 1015                 1020             


Ala Thr  Phe Asn Ile Ala Lys  Arg Gly Leu 
    1025                 1030             


<210>  16
<211>  1168
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.10İ

<400>  16

Met Glu Thr Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Glu Ala 
1               5                   10                  15      


Asp Glu Glu Asn Ser Ile His Ile Lys Glu Asp Ile Ile Asn Ile Glu 
            20                  25                  30          


Thr Asn Asp Asn Glu Phe Thr Met Val Asp Phe Val Ser Asn Leu Gly 
        35                  40                  45              


Asn Tyr Ile Lys Asp Leu Lys Asn Tyr Leu Phe Tyr Glu Lys Lys Asp 
    50                  55                  60                  


Gly Ser Leu Ser Phe Lys Asp Lys Ile Ile Ile Lys Asn Glu Trp Leu 
65                  70                  75                  80  


Arg Gln Tyr Ala Lys Gln Asp Phe Val Glu Leu Lys Ser Lys Lys Arg 
                85                  90                  95      


Ile Asn Leu Arg Asn Asn Arg Met Glu Gln Ile Lys Ile Gly Asp Ile 
            100                 105                 110         


Pro Arg Leu Ser Ser Lys Ile Glu Glu Ala Leu Asp Ile Ala Lys Glu 
        115                 120                 125             


Ile Tyr Ser Lys Leu Ser Asp Asp Ala Thr Leu Glu Gln His Glu Arg 
    130                 135                 140                 


Thr Lys Lys Ala Gln Ile Gly Leu Leu Leu Lys Arg Leu Glu Ala Lys 
145                 150                 155                 160 


Asn Val Leu Pro Leu Leu Met Asp Leu Val Lys Glu Thr Leu Asp Lys 
                165                 170                 175     


Asp Glu Thr Asp Asp Leu Ser Ile Arg Leu Lys Arg Gln Ser Gln Lys 
            180                 185                 190         


Ile Asn Ser Gln Leu Lys Ile Ala Ile Arg Ser Phe Leu Pro Glu Gln 
        195                 200                 205             


Ser Asn Gly Leu Gln Ile Ala Lys Ala Ser Phe Asn Tyr Tyr Thr Ile 
    210                 215                 220                 


Asn Lys Lys Pro Ile Asp Phe Glu Lys Lys Ile Glu Asp Leu Lys Lys 
225                 230                 235                 240 


Asn Leu Asn Val Lys Asp Leu Glu Lys Leu Asn Val Tyr Phe Asp Lys 
                245                 250                 255     


Lys Glu Lys Lys Gln Lys Asn Tyr Leu Gly Lys Lys Ile Phe Ser Leu 
            260                 265                 270         


Phe Glu Thr Asp Ile Gln Lys Ala Leu Ser Lys Asn Gln Pro Leu Tyr 
        275                 280                 285             


Leu Gly Asp Ala Pro Met Ile Asp Ser Ala Tyr Val Ser Leu Arg Gln 
    290                 295                 300                 


Ile Phe Lys Lys Ile Lys Ser Glu Gln Lys Lys Gln Phe Ser Glu Leu 
305                 310                 315                 320 


Met Gln Asn Lys Cys Ser Tyr Asp Glu Leu Lys Asn Ser Asn Leu Tyr 
                325                 330                 335     


Leu Leu Asn Asp Ile Gly Leu Glu Gln Phe Asn Thr Tyr Arg Glu Lys 
            340                 345                 350         


Thr Lys Glu Leu Glu Glu Leu Ala Thr Lys Leu Ser Asn Gln Asn Leu 
        355                 360                 365             


Leu Glu Asn Ala Lys Glu Arg Leu Arg Ser Gln Lys Glu Lys Ile Ala 
    370                 375                 380                 


Lys Glu Arg Gly Asn Ile Met Lys Asp Arg Phe Gln Thr Trp Lys Ser 
385                 390                 395                 400 


Phe Ala Asn Phe Tyr Arg Thr Val Ser Gln Lys His Gly Lys Ile Leu 
                405                 410                 415     


Ala Gln Leu Lys Gly Ile Glu Lys Glu Gln Ala Glu Ser Gln Leu Leu 
            420                 425                 430         


Lys Tyr Trp Ala Leu Ile Cys Glu Lys Glu Asn Gln His Gln Leu Trp 
        435                 440                 445             


Leu Ile Pro Arg Glu Lys Ala Trp Glu Cys Lys Arg Trp Leu Glu Thr 
    450                 455                 460                 


Val Asn Asp Thr Ser Ile Asp Asn Glu Asn Ser Ile Lys Leu Tyr Trp 
465                 470                 475                 480 


Phe Glu Ser Leu Thr Tyr Arg Ser Leu Gln Lys Leu Cys Phe Gly Phe 
                485                 490                 495     


Leu Glu Asn Gly Asn Asn Glu Phe Asn Gln Asn Ile Lys Asp Leu Leu 
            500                 505                 510         


Pro Lys Asp Arg Ile Gly Asn Thr Ile Asn Gly Glu Phe Ala Phe Glu 
        515                 520                 525             


Gly Asp Glu Glu Arg Lys Ile Glu Phe Tyr Lys Thr Val Leu Asn Ser 
    530                 535                 540                 


Lys Tyr Ala Lys Gln Val Leu Asn Ile Pro Phe Lys Gln Val Glu Glu 
545                 550                 555                 560 


Glu Ile Ile Ser Gln Ser Phe Glu Asn Leu Ser Asp Phe Gln Ile Ala 
                565                 570                 575     


Leu Glu Lys Ile Cys Tyr Arg Arg Phe Ala Ile Tyr Ser Asn Tyr Ile 
            580                 585                 590         


Ile Ser Phe Asp Ala Gln Ile Phe Asp Ile Thr Ser Leu Asp Leu Lys 
        595                 600                 605             


Asn Asn Glu Lys Asn Asn Leu Asn Thr His Thr His Ile Trp Arg Asp 
    610                 615                 620                 


Phe Trp Lys Asp Glu Asn Glu Lys Asn Asn Phe Asp Ile Arg Leu Asn 
625                 630                 635                 640 


Pro Glu Ile Thr Ile Ser Tyr Arg Thr Pro Lys Gln Ser Arg Ile Glu 
                645                 650                 655     


Lys Tyr Gly Glu Lys Thr Lys Glu Tyr Asp Pro Asn Lys Asn Asn Arg 
            660                 665                 670         


Tyr Leu His Pro Gln Phe Thr Leu Ile Thr Thr Ile Ser Glu Arg Ser 
        675                 680                 685             


Asn Ser Gln Thr Lys Thr Leu Ser Phe Ile Glu Asp Glu Asp Phe Lys 
    690                 695                 700                 


Lys Ser Ile Asn Glu Phe Asn Lys Lys Leu Lys Lys Asp Asn Ile Lys 
705                 710                 715                 720 


Phe Ala Phe Gly Ile Asp Asn Gly Glu Val Glu Leu Ser Thr Leu Gly 
                725                 730                 735     


Val Tyr Leu Pro Thr Phe Glu Lys Glu Thr His Glu Glu Lys Ile Tyr 
            740                 745                 750         


Glu Leu Lys Gln Ile Lys Lys Tyr Gly Phe Glu Val Leu Thr Ile Thr 
        755                 760                 765             


Asp Leu Lys Tyr Lys Glu Thr Asp Tyr Asn Gly Asn Val Arg Lys Ile 
    770                 775                 780                 


Ile Gln Asn Pro Ser Tyr Phe Leu Lys Lys Glu Asn Tyr Ile Arg Thr 
785                 790                 795                 800 


Phe Ser Lys Ser Glu Gln Glu Tyr Glu Glu Met Phe Ala Lys Leu Phe 
                805                 810                 815     


Lys Lys Glu His Val Leu Ser Leu Asp Leu Thr Thr Ala Lys Met Ile 
            820                 825                 830         


Cys Gly His Ile Val Thr Asn Gly Asp Val Pro Ala Leu Phe Asn Leu 
        835                 840                 845             


Trp Leu Lys His Ala Gln Arg Asn Val Phe Glu Met Asn Asp His Thr 
    850                 855                 860                 


Val Lys Glu Thr Ala Lys Thr Ile Arg Leu Arg Asn Asn Glu Glu Leu 
865                 870                 875                 880 


Thr Asp Asn Glu Lys Glu Lys Phe Ala Glu Phe Ile Ser Asp Gly Lys 
                885                 890                 895     


Lys Phe Ala Lys Leu Thr Lys Glu Gly Lys Lys Ser Arg Tyr Leu Lys 
            900                 905                 910         


Trp Ile Phe Glu Asp Arg Lys Glu Asn Ser Phe Thr Glu Asp Glu Asn 
        915                 920                 925             


Lys Lys Phe Asn Asp Cys Gln Lys Lys Lys Gly Lys Tyr Asn Ser His 
    930                 935                 940                 


Ile Ile Phe Ala Ser Arg Phe Glu Gly Asp Glu Leu Lys Ser Val Thr 
945                 950                 955                 960 


Pro Ile Phe Asp Cys Arg His Val Phe Lys Lys Arg Lys Glu Phe Glu 
                965                 970                 975     


Thr Ile Arg Pro Ile Lys Glu Ile Glu Asn Glu Ile Ser Arg Phe Asn 
            980                 985                 990         


Thr Asn Arg Thr Ser His Asn Ile  Ser Asn Glu Glu Leu  Asp Leu Lys 
        995                 1000                 1005             


Ile Thr  Asp Ala Lys Lys Ala  Leu Val Ala Asn Ala  Ile Gly Val 
    1010                 1015                 1020             


Ile Asp  Phe Leu Tyr Lys Gln  Tyr Lys Gln Arg Phe  Asn Asp Glu 
    1025                 1030                 1035             


Gly Leu  Ile Ile Lys Glu Gly  Phe Asp Thr Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Asp Ile  Glu Lys Phe Ser Gly  Asn Ile Tyr Arg Ile  Leu Glu Arg 
    1055                 1060                 1065             


Lys Leu  Tyr Gln Lys Phe Gln  Asn Tyr Gly Leu Val  Pro Pro Ile 
    1070                 1075                 1080             


Lys Asn  Leu Met Ala Val Arg  Asn Glu Gly Ile Lys  Asp Lys Asn 
    1085                 1090                 1095             


Ala Ile  Leu Arg Leu Gly Asn  Ile Ala Phe Ile Asp  Pro Ser Gly 
    1100                 1105                 1110             


Thr Ser  Gln Glu Cys Pro Val  Cys Lys Glu Lys Ser  Lys Glu Lys 
    1115                 1120                 1125             


His Thr  Asn Asn Phe Ile Cys  Glu Cys Gly Phe Asn  Ser Thr Asn 
    1130                 1135                 1140             


Ile Met  His Ser Asn Asp Gly  Ile Ala Gly Phe Asn  Ile Ala Lys 
    1145                 1150                 1155             


Arg Gly  Phe Glu Asn Phe Ile  Asn Glu Lys 
    1160                 1165             


<210>  17
<211>  1187
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.11İ

<400>  17

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Arg Leu Asp Ala 
1               5                   10                  15      


Asp Asn Thr Ala Ile Ser Ala Ile Val Lys Asp Thr Glu Ala Leu Glu 
            20                  25                  30          


Ala Arg Gly Gln Gly Phe Lys Ile Lys Lys Phe Val Asn Ala Leu Gly 
        35                  40                  45              


Arg Phe Leu Ser Gly Asp Gly Val Gln Lys Tyr Leu Tyr Asp Met Ser 
    50                  55                  60                  


Asn Glu Glu Asn Cys Val Phe Lys Arg Asn Leu Val Ile Lys Asn Thr 
65                  70                  75                  80  


Trp Leu Lys Asn Asn Ala Lys Gln Glu Ile Ala Gly Met Asp Leu Lys 
                85                  90                  95      


Arg Gly Leu Ile Ile Lys Asp Ile Lys Gly Leu Gln Asp Lys Ile Glu 
            100                 105                 110         


Glu Ile Tyr Asp Lys Leu Trp Glu Ile Tyr Glu Ile Leu Tyr Glu Ser 
        115                 120                 125             


Ala Tyr Leu Pro Leu Gln Asp Leu Ala Arg Arg Glu Gly Ile Gly Leu 
    130                 135                 140                 


Leu Leu Lys Lys Leu Ser Val Lys Asn Ala Leu Pro Phe Ile Ile Ser 
145                 150                 155                 160 


Phe Val Glu Glu Ser Asn Asp Lys Asn Glu Ala Asp Asp Leu Ser Leu 
                165                 170                 175     


Arg Leu Lys Lys Gln Gly Lys Glu Ile Leu Thr Gln Leu Glu Ile Gly 
            180                 185                 190         


Ile Asn Glu Tyr Leu Pro Ala Gln Ser Ser Gly Leu Pro Val Ala Lys 
        195                 200                 205             


Ala Ser Phe Asn Tyr Tyr Thr Ile Asn Lys Thr Pro Val Asp Phe Gly 
    210                 215                 220                 


Glu Lys Ile Gln Glu Leu Glu Lys Arg Leu Ser Val Asp Ile Lys Lys 
225                 230                 235                 240 


Glu Ile Ser Ser Phe Thr Gly Gly Ile Lys Thr Ala Ile Lys Asn Lys 
                245                 250                 255     


Ile Ala Gly Lys Lys Ile Leu Leu Gly Asp Thr Pro Met Phe Glu Ser 
            260                 265                 270         


Glu Asn Ser Val Ser Leu Arg Gln Ile Leu Lys Asn Ile Lys Ser Glu 
        275                 280                 285             


Gln Lys Ala Gln Phe Asn Lys Phe Met Thr Thr Gln Asn Asn Pro Gln 
    290                 295                 300                 


Leu Glu Glu Met Lys Thr Met Gly Trp Tyr Leu Phe Gly Asp Ile Thr 
305                 310                 315                 320 


Glu Gly Glu Phe Asn Asp Tyr Lys Glu Gln Thr Lys Glu Ile Glu Arg 
                325                 330                 335     


Val Gly Ala Lys Ile Asn Gln Cys Gly Asn Ile Lys Glu Lys Lys Glu 
            340                 345                 350         


Leu Arg Ser Gln Leu Gln Lys Leu Lys Lys Lys Arg Gly Glu Leu Ile 
        355                 360                 365             


Ser Glu Ala His Lys Lys Gly Gly Asn Asp Lys Asn Phe Lys Thr Tyr 
    370                 375                 380                 


Lys Glu Phe Ala Lys Phe Tyr Arg Lys Ile Ala Gln Arg His Gly Lys 
385                 390                 395                 400 


Ile Leu Ala Gln Ile Lys Gly Ile Glu Lys Glu Lys Ile Asp Ser Ala 
                405                 410                 415     


Met Leu Asn Tyr Trp Ala Ala Val Ile Glu Leu Ser Gly Arg His Lys 
            420                 425                 430         


Leu Val Leu Ile Pro Lys Lys Asp Glu Asn Ala Lys Lys Cys Ile Glu 
        435                 440                 445             


Trp Leu Glu Asp Glu Ser Lys His Lys Asn Gly Ser Cys Lys Ile Phe 
    450                 455                 460                 


Trp Phe Glu Ser Phe Thr Phe Arg Ser Leu Gln Lys Leu Cys Phe Gly 
465                 470                 475                 480 


Asn Leu Asp Ser Gly Thr Asn Thr Phe Asn Gln Lys Ile Gln Asn Leu 
                485                 490                 495     


Leu Pro Cys Asp Glu Arg Gly Asn Leu Met Asn Gly Glu Phe Ala Phe 
            500                 505                 510         


Lys Gly Asp Glu Gln Glu Lys Ile Lys Phe Tyr Lys Lys Val Leu Gln 
        515                 520                 525             


Ser Gln Lys Asp Ile Asn Leu Pro Gln Lys Glu Val Val Asp Asn Val 
    530                 535                 540                 


Val Gly Arg Lys Phe Glu Thr Met Asp Glu Phe Lys Ile Ala Leu Glu 
545                 550                 555                 560 


Glu Ile Cys Tyr Ile Arg Arg Glu Arg Leu Ser Ala Asn Ala Glu Ser 
                565                 570                 575     


Glu Leu Lys Ser Lys Phe Asn Ala Gln Ile Phe Asp Ile Thr Ser Leu 
            580                 585                 590         


Asp Leu Arg Asn Pro Val Asn Cys Ala Gly Lys Pro Glu Val Tyr His 
        595                 600                 605             


His Asn Asp Lys Arg His Thr Glu Ile Trp Lys Glu Phe Trp Ser Leu 
    610                 615                 620                 


Asp Asn Glu Arg Arg Asn Phe Asn Ile Arg Leu Asn Pro Glu Ile Thr 
625                 630                 635                 640 


Ile Thr Tyr Arg Lys Pro Lys Glu Ser Arg Ile Leu Lys Tyr Gly Lys 
                645                 650                 655     


Gly Thr Glu Lys Tyr Asn Ala Asp Met Lys Asn Arg Tyr Leu Tyr Pro 
            660                 665                 670         


Gln Tyr Thr Leu Leu Thr Thr Ile Ser Glu His Cys Asn Thr Pro Thr 
        675                 680                 685             


Lys Ile Leu Ser Phe Met Thr Asp Asn Glu Tyr Glu Glu Ser Ile Lys 
    690                 695                 700                 


Ala Phe Asn Ser Lys Leu Lys Lys Glu Asp Ile Lys Phe Ala Phe Gly 
705                 710                 715                 720 


Ile Asp Ser Gly Glu Thr Glu Leu Ser Thr Leu Gly Val Tyr Leu Pro 
                725                 730                 735     


Glu Phe Ser Ala Glu Ser Thr Glu Leu Lys Asp Ile Glu Lys Tyr Gly 
            740                 745                 750         


Phe Asn Val Leu Thr Ile Lys Asp Leu Asn Tyr Thr Glu Thr Asp Tyr 
        755                 760                 765             


Asn Gly Ser Asp Lys Lys Ile Val Lys Asn Pro Ser Tyr Phe Val Asp 
    770                 775                 780                 


Lys Ser Leu Tyr Met Arg Thr Phe Lys Lys Thr Glu Gln Glu Tyr Glu 
785                 790                 795                 800 


Lys Met Phe Ala Glu Gln Phe Glu Ala Lys Lys Arg Leu Ser Leu Asp 
                805                 810                 815     


Leu Ser Ala Ala Lys Val Ile Cys Gly His Ile Val Thr Asn Gly Gly 
            820                 825                 830         


Val Ser Glu His Phe Gly Leu Trp Leu Lys His Ala Gln Arg Thr Ile 
        835                 840                 845             


Phe Trp Met Asn Asp His Thr Glu Lys Lys Thr Ala Lys Asn Ile Lys 
    850                 855                 860                 


Leu Lys Asp Ser Ser Glu Leu Thr Tyr Asp Glu Arg Glu Lys Phe Ala 
865                 870                 875                 880 


Glu His Ile Ser Ser Asp Glu Lys Phe Lys Lys Leu Asp Val Glu Glu 
                885                 890                 895     


Lys Lys Arg Tyr Val Arg Trp Ile Phe Glu Asp Arg Glu Thr Leu Asn 
            900                 905                 910         


Phe Thr Glu Ala Glu Asn Lys Lys Phe Gly Gly Tyr Gln Lys Lys Lys 
        915                 920                 925             


Gly Asp Tyr Arg Leu Gly Ile Leu Phe Ala Ser Cys Phe Ile Gly Lys 
    930                 935                 940                 


Glu Leu Glu Ser Val Thr Gln Ile Leu Asp Cys Arg His Ile Phe Lys 
945                 950                 955                 960 


Lys Arg Glu Glu Phe Tyr Ser Leu Lys Ser Lys Glu Asp Ile Glu Ala 
                965                 970                 975     


Glu Ile Lys Arg Tyr Asn Thr Asp Tyr Thr Asn His Asn Ile Ser Thr 
            980                 985                 990         


Glu Gln Leu Asp Leu Lys Phe Val  Asn Val Lys Asn Ala  Leu Val Ala 
        995                 1000                 1005             


Asn Ala  Val Gly Val Ile Asp  Leu Leu Tyr Lys Gln  Tyr Lys Glu 
    1010                 1015                 1020             


Arg Leu  Gly Gly Glu Gly Leu  Ile Ala Lys Glu Gly  Phe Asp Thr 
    1025                 1030                 1035             


Lys Lys  Val Glu Glu Asp Met  Glu Lys Phe Ser Gly  Asn Ile Tyr 
    1040                 1045                 1050             


Arg Ile  Leu Glu Arg Lys Leu  Tyr Gln Lys Phe Gln  Asn Tyr Gly 
    1055                 1060                 1065             


Leu Val  Pro Pro Ile Lys Asn  Leu Met Ala Val Arg  Ala Asp Lys 
    1070                 1075                 1080             


Val Glu  Ile Ser Glu Ala Glu  Lys Ser Lys Ile Arg  Glu Asn Cys 
    1085                 1090                 1095             


Lys Ile  Ser Lys Ile Asp Pro  Glu Asn Glu Ile Ile  Lys Arg Asn 
    1100                 1105                 1110             


Lys Thr  Leu Ile Leu Arg Leu  Gly Ser Ile Ala Phe  Val Asn Asp 
    1115                 1120                 1125             


Ala Asp  Thr Ser Gln Glu Cys  Pro Ala Cys Gly Thr  Lys Ser Lys 
    1130                 1135                 1140             


Glu Lys  His Val Asp Asn Phe  Ile Cys Gly Cys Gly  Phe Asn Ser 
    1145                 1150                 1155             


Thr Gly  Ile Ile His Ser Asn  Asp Gly Val Ala Gly  Phe Asn Ile 
    1160                 1165                 1170             


Ala Lys  Arg Gly Phe Val Asn  Leu Met Glu His Glu  Leu Arg 
    1175                 1180                 1185         


<210>  18
<211>  1195
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.12İ

<400>  18

Met Glu Lys Tyr Lys Leu Thr Lys Thr Ile Arg Phe Lys Leu Lys Pro 
1               5                   10                  15      


Lys Asp Ile Ser Ala Ile Lys Arg Asp Val Glu Ala Leu Glu Gln Gln 
            20                  25                  30          


Lys Phe Asp Leu Val Leu Phe Val Tyr Asn Leu His Asn Phe Ile Gly 
        35                  40                  45              


Lys Leu Lys Glu Tyr Leu Phe Phe Gln Lys Glu Lys Asp Glu Phe Val 
    50                  55                  60                  


Ile Lys Asp Lys Leu Thr Ile Lys Lys Thr Trp Leu Lys Gln Tyr Ala 
65                  70                  75                  80  


Lys Gln Glu Ile Ala Gly Leu Glu Leu Asn Arg Glu Gln Thr Leu Gly 
                85                  90                  95      


Asn Ile Lys Gly Val Ser Ala Arg Ile Glu Arg Ala Val Asp Asp Val 
            100                 105                 110         


Asn Lys Ile Tyr Val Glu Leu Ala Met Glu Ala Lys Leu Asn Glu Arg 
        115                 120                 125             


Ala Lys Lys Ala Lys Thr Glu Gln Leu Ile Lys Arg Leu Asp Thr Arg 
    130                 135                 140                 


Asn Ala Leu Pro Leu Leu Val Ser Leu Ile Glu Gln Ser Ser Asp Lys 
145                 150                 155                 160 


Tyr Glu Thr Gly Asn Leu Ser Ile Gln Leu Lys Arg Leu Gly Lys Arg 
                165                 170                 175     


Leu Gln Thr Gln Leu Leu Ser Gly Ile Lys Lys Tyr Leu Ala Glu Gln 
            180                 185                 190         


Ser Asn Gly Leu Pro Ile Ala Lys Ala Ser Phe Asn Tyr Tyr Ala Ile 
        195                 200                 205             


Asn Lys Lys Pro Val Asp Tyr Ile Asp Lys Ile Lys Gln Leu Gln Lys 
    210                 215                 220                 


Asp Leu Glu Ile Lys Lys Asn Arg Arg Ser Glu Glu Arg Tyr Asp Lys 
225                 230                 235                 240 


Lys Lys Arg Lys Asn Ile Lys Ile Phe Asn Asp Ser Lys Leu Trp Ile 
                245                 250                 255     


Lys Ile Lys Lys Asp Ile Glu Lys Glu Arg Gly Asn Lys Thr Leu Ile 
            260                 265                 270         


Leu Gly Tyr Ala Pro Met Ile Glu Pro Gly Asn Tyr Val Tyr Leu Arg 
        275                 280                 285             


Gln Ile Leu Lys Asn Ile Lys Leu Glu Gln Lys Asn Lys Phe Ser Lys 
    290                 295                 300                 


Leu Met Gln Ser Lys Ser Leu Thr Phe His Asp Leu Asn Asn Asn Asn 
305                 310                 315                 320 


Gln Leu Tyr Leu Phe Lys Asp Ile Leu Glu Gly Glu Phe Asn Lys Tyr 
                325                 330                 335     


Lys Gln Lys Thr Asn Glu Ile Glu Thr Lys Ala Glu Lys Arg Asn Gln 
            340                 345                 350         


Cys Asn Asn Asp Glu Leu Lys Arg Lys Leu Asn Ser Glu Leu Gln Gln 
        355                 360                 365             


Leu Arg Lys Asp Arg Gly Ser Leu Ile Asn Ala Ala Asp Gly Arg Pro 
    370                 375                 380                 


Lys Gly Arg Phe Lys Thr Tyr Lys Tyr Phe Ala Asn Phe Tyr Arg Asn 
385                 390                 395                 400 


Val Ala Gln Lys His Gly Arg Ile Leu Ser Thr Leu Lys Gly Ile Glu 
                405                 410                 415     


Lys Glu Met Val Glu Ser Gln Leu Leu Lys Tyr Trp Thr Ile Ile Thr 
            420                 425                 430         


Glu Glu Asn Asn Gln His Ser Leu Val Leu Ile Pro Lys Glu Arg Ala 
        435                 440                 445             


Gly Glu Tyr Lys Lys Asp Leu Glu Asn Ser Ile Pro Ser Asp Pro Ser 
    450                 455                 460                 


Ser Lys Ile Lys Val Tyr Trp Phe Glu Ser Phe Thr Leu Arg Ser Leu 
465                 470                 475                 480 


Arg Lys Leu Cys Phe Gly Tyr Val Asn Asn Asn Thr Gly Ser Asn Thr 
                485                 490                 495     


Phe Tyr Pro Glu Leu Lys Lys Ser Asp Glu Leu Arg Lys Tyr His Asp 
            500                 505                 510         


Glu Arg Gly Asn Phe Ile Lys Gly Glu Phe Tyr Phe Lys Gly Asp Glu 
        515                 520                 525             


Gln Lys Ile Ile Gln Phe Tyr Lys Asp Val Leu Arg Ser Asn Tyr Ala 
    530                 535                 540                 


Gln Lys Val Leu Lys Phe Pro Lys Gln Gln Val Lys Asp Glu Leu Ile 
545                 550                 555                 560 


Gly Arg Glu Phe Ser Ser Leu Asp Glu Phe Gln Ile Ala Leu Glu Lys 
                565                 570                 575     


Ile Cys Tyr Gln Arg His Val Val Cys Ser Gln Lys Val Val Asp Ala 
            580                 585                 590         


Leu Ser Arg Tyr Asn Ala Gln Ile Phe Leu Ile Thr Ser Leu Asp Leu 
        595                 600                 605             


Gly Asn Pro Ala Asn Cys Val Asp Lys Pro Lys Gln Phe Ser His Phe 
    610                 615                 620                 


Asp Lys Lys His Thr Arg Ile Trp Lys Glu Phe Trp Ser Ser Lys Asn 
625                 630                 635                 640 


Glu Thr Ala Asn Phe Asp Ile Arg Leu Asn Pro Glu Ile Val Ile Thr 
                645                 650                 655     


Tyr Arg Gln Pro Lys Gln Ser Arg Ile Lys Lys Tyr Gly Pro Glu Ser 
            660                 665                 670         


Thr Arg Tyr Asp Asp Arg Lys His Asn Arg Tyr Leu Tyr Pro Gln Phe 
        675                 680                 685             


Thr Leu Ile Thr Thr Ile Ser Glu Tyr Ser Asn Ala Pro Thr Lys Ala 
    690                 695                 700                 


Leu Ser Phe Leu Thr Asp Glu Glu Phe Lys Gly Ala Val Asp Glu Phe 
705                 710                 715                 720 


Asn Lys Lys Phe Lys Lys Glu Asn Ile Arg Phe Ser Leu Gly Ile Asp 
                725                 730                 735     


Asn Gly Glu Thr Glu Leu Ser Thr Leu Gly Val Tyr Leu Pro Val Phe 
            740                 745                 750         


Lys Lys Asp Ser Asn Glu Lys Val Val Ala Glu Leu Lys Lys Val Asn 
        755                 760                 765             


Lys Tyr Gly Phe Asn Phe Leu Thr Ile Lys Asp Leu Ser His Val Glu 
    770                 775                 780                 


Lys Asp Lys Asn Gly Arg Val Arg Lys Ile Ile Gln Asn Pro Ser Tyr 
785                 790                 795                 800 


Phe Leu Ser Lys Glu Gln Tyr Met Arg Thr Phe Gly Arg Thr Glu Gln 
                805                 810                 815     


Glu Tyr Asn Asn Met Phe Ala Glu Gln Phe Glu Glu Lys Ala Phe Leu 
            820                 825                 830         


Ser Leu Asp Leu Thr Thr Ala Lys Val Ile Asn Gly His Ile Val Thr 
        835                 840                 845             


Asn Gly Asp Val Pro Thr Phe Leu Asn Leu Trp Met Arg His Ala Gln 
    850                 855                 860                 


Arg Asp Ile Trp Asp Met Asn Asp His Thr Lys Glu Lys Thr Ala Lys 
865                 870                 875                 880 


Lys Ile Val Ile Lys Asn Asn Asp Glu Leu Thr Asp Ala Glu Lys Val 
                885                 890                 895     


Lys Phe Val Glu Tyr Ile Ser Asp Glu Thr Asn Tyr Ala Lys Leu Asn 
            900                 905                 910         


Phe Asn Glu Lys Lys Arg Tyr Val Leu Trp Ile Phe Glu Asn Arg Lys 
        915                 920                 925             


Asn Ile Asn Phe Thr Asp Ala Glu Lys Lys Lys Phe Glu Pro Cys Gln 
    930                 935                 940                 


Lys Arg Lys Gly Asn Phe Ser Lys Asp Ile Leu Phe Ala Val Cys Tyr 
945                 950                 955                 960 


Ile Gly Ser Glu Ile His Ser Val Thr Asn Ile Phe Asp Val Arg Asn 
                965                 970                 975     


Ile Phe Lys Met Arg Lys Asp Phe Tyr Val Leu Lys Ser Glu Met Glu 
            980                 985                 990         


Ile Lys Lys Glu Ile Glu Ser Tyr  Asn Thr Thr Ala Gly  Ile Gln Glu 
        995                 1000                 1005             


Ile Ser  Asn Glu Glu Leu Asp  Leu Lys Ile Asn Arg  Leu Lys Gln 
    1010                 1015                 1020             


Ala Val  Val Ala Asn Ala Val  Gly Val Ile Asp Tyr  Leu Tyr Ile 
    1025                 1030                 1035             


Tyr Tyr  Lys Lys Lys Thr Gly  Gly Glu Gly Leu Ile  Ile Lys Glu 
    1040                 1045                 1050             


Gly Phe  Asp Thr Lys Lys Val  Ala Lys Ala Leu Glu  Lys Phe Ser 
    1055                 1060                 1065             


Gly Asn  Ile Tyr Arg Ile Leu  Glu Arg Lys Leu Tyr  Gln Lys Phe 
    1070                 1075                 1080             


Gln Asn  Tyr Gly Leu Val Pro  Pro Ile Lys Ser Leu  Met Ala Val 
    1085                 1090                 1095             


Arg Glu  Glu Gly Ile Glu Asn  Asn Lys Asp Ala Ile  Leu Arg Leu 
    1100                 1105                 1110             


Gly Asn  Val Gly Phe Ile Asp  Pro Thr Gly Thr Ser  Gln Gln Cys 
    1115                 1120                 1125             


Pro Val  Cys Ser Lys Gly Lys  Leu Asn His Thr Thr  Lys Cys Ser 
    1130                 1135                 1140             


Lys Asn  Cys Gly Phe Asn Ser  Lys Asn Ile Met His  Ser Asn Asp 
    1145                 1150                 1155             


Gly Ile  Ala Gly Tyr Asn Ile  Ala Lys Arg Gly Phe  Glu Asn Phe 
    1160                 1165                 1170             


Ile Ser  Gln Lys Lys Gly Tyr  Asp Val Ile Asn Asn  Gly Thr Lys 
    1175                 1180                 1185             


Tyr Asn  Asn Leu Lys Ser Gln  
    1190                 1195 


<210>  19
<211>  2649
<212>  DNA
<213>  ˹

<220>
<223>  Cas12g.1

<400>  19
atgctgtaca ccatgaacgt gaagaccatc aagctgaagg tggacgccac caaggaggtg       60

gagtccaggc tgaccaagat gctgctggtg cacaacaaca tcggcaggga gatcatcaac      120

ttcctgatcc tgtgctccgg caacgacaac atcaggaaga ccaagttcga cgagttcggc      180

aactcctacg acgagttctg caacctgaag ctggaccagt tcaacctgta cgacaggctg      240

accgagatcc acgacgaggt gaccctggag gacttccaga agaccctgaa cgacatctac      300

gacctggtgc tgaactccaa gtccttctcc aacgtgtcct ccaccatctt caacaagaac      360

aagaaggtga acttcgacga gaccaagaag ggcgacctgt ccaggaagtg cctgatgaac      420

gccagggact ggggcgtgct gccgctgatc tccgtggacg acgacatcgt gacctgcggc      480

accctgaagg gcatcctgtc cgagtgccag tccaggatcc tgtcctggaa cgagtgcaac      540

ctgtccacca aggagaccta ctccgagaag aagtccgagt accagtccat cctggacgac      600

tccatgacca aggacgccga cgtgaccacc gccatgatcc agttcatgga cgacgtgtcc      660

aacgtgtacg gctccaacaa cgagaaccag ctgaagtggt tcaacaacag gttcctgacc      720

tacgtgagga acaagatcag gccgttcctg ctgaccaact ccccgatcga caacttcgag      780

cagtccgaca cctcctacaa ctgctccatc gagatcgtga ggatcctgtc caagtacgag      840

atcctgtgga aggacgaggt gtccgtgaac aggtacaaga agacctgcga cgacggcatc      900

aacatcgaga agtacaggta cctggtgcac gccaagtccg acttcctgag gtacaaggag      960

accgcctcct tcaaggagat ccacgccgtg aagtccccga tctccctgtg cttcggcaac     1020

aactaccagc cgttctccct gtccgacgtg ggcgacaggc acaacatcaa cttcggctac     1080

aagttcggca agctgggcaa gcagaggaag gagtgctcct tcaacctgaa ctacaggagg     1140

aagaaggtga agtacgccaa caccccggtg aggtccgacg agaacaagtg ctacctggac     1200

aacctggaga tcgaggacgc caagaacggc tcctacaagc tgtcctacat ggtgaacaag     1260

aagtacaaga gggagtcctt catcaaggag ccgaagatga agatgtacaa cggcaagctg     1320

tacatgtact tcccgatgtc caacgagttc gaggaggaca gggactcctt cgccctgctg     1380

acctacttct ccaggtcctc caactccaag tcccagatcg acgaggcctc caacatcctg     1440

cagaacagga agatcagggt gtgcggcgtg gacctgggca tcaacccgac cttcgccctg     1500

tccgtgctgg agtactccga caacaagatc accgacacca acatcggcat gaagcacgag     1560

ggctcctaca acaacttctc cgagatcagg aagcagatca acgacgtgac cgacatgatc     1620

tcctacctga agtccaagta cgacaactgc gagaaggact actcctccaa gatcgacgac     1680

cacatcaagt ccaggctgaa cgaggagatc tccaacttct gcgacctggt gtcctacaag     1740

aggaacaaga acaccatcat caggaaggag atcaagaacg tggagaagga gatcaacaag     1800

atcaagaact gcaggaggca caccctgaag aaggacctga ccgagaactt cggctgggtg     1860

tccgccctga acgagttcat ctccctgaag cactccttca acgacatggg cgagtccttc     1920

gactccaaga ccaacccgtc ctactcctac ttcgagaagt ggaagaggta catcgacaac     1980

atcaaggacg actccctgaa gaccgtgtcc agggagatcc tgaacttctg catcgagaac     2040

tccgtggact tcatcgccct ggaggacctg cagaccttcg ccccgtccga cgacaggacc     2100

aagtcccaca acaagctgac ccagctgtgg tgcttcggca agctgaagaa gtgcctggag     2160

gacatcgcct ccatgtacgg catccacgtg tactcctcca ccgacccgag gaacacctcc     2220

gacacccact tcgagtccaa gaacttcggc tacagggacg agtccaacaa gcacaacctg     2280

tgggtgaacg tggacggcga gtacaccgtg gtggactccg acatcaacgc ctccaagaac     2340

atcgccaaca ggttcctgac ccaccacaag gacctgaagc agctgccgat gatcggcgac     2400

ggcaccctgt tcaagatcga ctcctcctcc aagaggaaca agtccttcgc cgtgaagctg     2460

aacatccaca agaacgtgta cgagctgatc gacggcgagt tcgtgaagtc caacaagaag     2520

ccgaacggca cctccaggaa gcagaccgcc tacatccacg gcgacatgtt catcgactcc     2580

atctcccaca agaacaagaa gatgttcctg agggagaacc tgatcaggaa cggcttcatc     2640

tccaagtga                                                             2649


<210>  20
<211>  2808
<212>  DNA
<213>  ˹

<220>
<223>  Cas12g.2

<400>  20
atgaacaaga ccgacaccca gaacaacgag cagatcaaca agccgaccca gctgctgaac       60

aacaaggaca tcgagctgac cgtgaagacc gtgaagtccg ccaccgtgaa ggtggacaac      120

aactccaaga aggagctgtt cggcctgttc aactacttca cctccgtggc ctccggcatc      180

aaggacaagg tgtacaacct gcagtccgac gagaagaccg ccccgatctt caacgactac      240

gtgaagcagc cgcagagggg caggtccgcc gccaccaccc tgttcaccaa gctggacgcc      300

gagaagacct acacctccca gcactccttc ccgggcaagt ggagggactc cggcatcttc      360

ccgctgtaca acaaggagtc cgagaagtac gacctgtcca cccacggcta ccactactcc      420

gccaacgccg agatccacac ccagctggac tcccacgacg agtgcaacaa ggagtgcgag      480

aaggagtacg ccgccctgag ggacgaggtg aacaactaca agtacgagtt caccctgcag      540

ttcaaggccg agaacgccga gaagttctac aacttcgtgg agaagctgac cctgatgggc      600

tggaggtacg acgccacctt caggtccttc ttcgagctgc acatgcaccc gaagctgaag      660

accggcgaga ccacctacag ggccacctac aagctgccgt ccggcaagtc caagaggtac      720

tccttcttca gggacgacat cgccgacgag atcgccaaga acccggagtt ctggccgatg      780

ctggagtcct ccaacgccat ctcctggatc aactccaaca acctgctgtc caggaagaag      840

gacaaggcca actactcctc cacctccctg atcaagtccc agatcaggct gtacctgggc      900

aacaacggcg tgccgttcac cgccagggag cacgacggca ggatctactt ctccttcagg      960

ctgccggcca tcaacggcga gaagggcagg atggtggaga tcccgtgctc ctacaagaag     1020

gtgttcaacg gcaaggccag gaagtcctgc tacctgggcg gcctgaccat cgagaagacc     1080

gacgccggca agcacatctt caagtactcc gtgaacaaca agaagccgca ggtggccgag     1140

ctgaacgagt gcttcctgag gctggtggtg aggaacaggg agtacttcaa caacgtggtg     1200

gccggcaaga tcaccgacat caacaccgac cacttcgact tctacgtgga cctgccgctg     1260

aacgtgaagg aggacccgat ccacgacctg tcctccaccg aggtgttcgg caagaacggc     1320

ctgaggtcct actactcctc cgcctacccg gagatcaaga acctgggctc ccagatcgag     1380

accggcaaga acctgacctg cccgatcacc aagacccaca acatcatggg catcgacctg     1440

ggccagagga acccgttcgc ctactgcatc aaggacaaca ccggcaagct gatcgcccag     1500

ggccacatgg acggctccaa gaacgagacc tacaagaagt acatcaactt cggcaaggag     1560

tccacctccg tgtcccacct gatcaaggag accaggtcct acctgcacgg cgacccggag     1620

gccatctcca aggagctgta caacgaggtg gccggcttct gcaacaaccc ggtgtcctac     1680

gaggagtacc tgaagtacct ggactccaag aagttcctga tcaacaagga ggacctgtcc     1740

aagaacgcca tgcacctgct gaggcagaag gaccacaact ggatcggcag ggactggctg     1800

tggtacatct ccaagcagta caagaagcac aacgagaaca ggatgcagga cgccgactgg     1860

aggcagaccc tgtactggat cgactccctg tacaggtaca tcgacgtgat gaagtccttc     1920

cacaacttcg gctccttcta cgacaagaac ctgaagaaga aggtgaacgg caccgtggtg     1980

ggcttctgca agaccgtgca cgaccagatc aacaacaaca acgacgacat gttcaagaag     2040

ttcaccaacg agctgatgtc cgtgatcagg gagcacaagg tgtccgtggt ggccctggag     2100

aagatggact ccatgctggg cgacaagtcc aggcacacct tcgagaacag gaactacaac     2160

ctgtggccgg tgggccagct gaagaccttc atggagggca agctggagtc cttcaacgtg     2220

gccctgatcg agatcgacga gaggaacacc tcccaggtgt gcaaggagaa ctggtcctac     2280

agggaggccg acgacctgta ctacgtgacc gacggcgagt cccacaaggt gcacgccgac     2340

gagaacgccg ccaacaacat cgtggacagg tgcatctcca ggcacaccaa catgttctcc     2400

ctgcacatgg tgaacccgaa ggacgactac tacgtgccga cctgcatctg ggacaccacc     2460

gaggagtccg gcaagagggt gaggggcttc ctgaccaagc tgtacaagaa ctccgacgtg     2520

gtgttcacca agaagggcga caagctggtg aagtccaaga cctccgtgaa ggagctgaag     2580

aagctggtgg gcaagaccaa ggagaagagg ggccagtact ggtacaggtt cgagggcaag     2640

tcctggatca acgaggccga cagggacacc atcatcctga acgccaagaa gatctccagg     2700

gagagggaca acggcgagca gtccaccgac accaggtccc agaacgtgac cgtgtccgtg     2760

ctggacgtgt gcgagaccgc cgagaagaag aagctggtgc tggtgtga                  2808


<210>  21
<211>  2664
<212>  DNA
<213>  ˹

<220>
<223>  Cas12h.1

<400>  21
atggccctga tccagagggc cggcgtgctg aagaccaagt ccgacttccc gaaggtgatc       60

aaggactggc acgactccct gctggccgac tacaggaagt tcttcccgat catcttctcc      120

tggtgcccgg agtacggcta caccaccatc caggacaaca agccggtgtt cgtgtccccg      180

gaggagagga tggagtccat caggaaggag gccaaggagc acctgaacga ggtgctggcc      240

ttcggcaaga tgatcggctc caagggcgtg ggcggctcct cctcctacgc catcttctac      300

aagcaccaca agaacaacga gaacggcgcc tacaccccgt ccagggccaa gttcatgaag      360

gagggcatcc acaacaggag ggtggagctg gtggacgtgc tgatgctgaa cgccatcccg      420

gacgaggagt gggtgaagat cgcccaggag gtggtgggct actccgagga gaggctgaag      480

ctgtactgga acaagttcat cgccaagagg gtggtgtccc acgacaggaa gctgggcaag      540

atcgtgaggg agaagtacct ggagccgaag ggcctggtgt gcgcccagcc ggagaactcc      600

acctactgca gggtgctgac cgagatcatc aagaggcagc tgcactccca gatcgagaag      660

tccaagttcc acgaggagga gctgaagtcc atcgagaaga ccgtgtccga gttcgactcc      720

ccgctgctgg acttcatctg ccagtacgcc gaggagctga accagatcaa ctccggcctg      780

tccaagtacg tgatcaagaa cgccgtgaag gaggtgatct ccccgccgga gaagcagtcc      840

gagatctacg tgcagtccca ggtgctgtcc caggagaagt acaagccgct ggtgaacgcc      900

accatcaagg agatcctgtc cggctacgag cagtggaagg tgaagtccag gtacgagaac      960

aggctgaaga acaggaagta cgtgctgtac ccgaagctgt ccgccaacta caagatcccg     1020

atcggccaga actccctggg caagttcaag atcaacgtgt ccgagaacgg cgagatcgtg     1080

atcaggctga acgacatggc cgacgtggtg tgcatgccgt ccaagtactt cttcaacctg     1140

aagtcctccc cggtggtgga caagaagaag cagctggtgg gctaccagat ctccttcaac     1200

cacaactcca ggaggaagga gccgaccgag aagccggact tcaacggcat cgtgaaggag     1260

atcggcctgc agctgaagga cgacggcagg ttctacatca ccctgccgta ctgcatggag     1320

tactccaacg acaacttcga cctgatcagg ccgctgctga cctcctcccc gaccgaggac     1380

cagatcaaga agatgccgtc cgagttcaac gtggtgggct tcgacctgaa cctgtccatg     1440

ccgctgccga tcaccagggc catcgtgggc aagtccgtga agggcgagat caacgtggag     1500

tacctgggcc aggccaaggt gatcgagtcc acccacctga tctacgacaa caacaggtgc     1560

aaggtgctga tcgcctacaa gaggcagtgc gacctgatca agagggccat cagggagtgg     1620

aagatctgca agggcaagaa catcgacatc tccgagaaga cctacgagtg gctggagtcc     1680

cacaccaaga ggtggaaccc gtccaggcag ccggagtcca tgcaggacag gttctccgtg     1740

tccaagatga ggatccagat cctggtgaac aaggccaagt ccaggatcgc caagtacaac     1800

gacaactcct ggaagaccgg ccacggcaac gagtccgagc tgatcaggct gatcgacgcc     1860

gacgacgcct acaactccct ggtgtccacc tacaacagga tccacctgaa gtccaaccag     1920

ttcatctacg ccctgccgtc caagaacaac tccaggtcca acaagaagga gtactgcctg     1980

aggaggatcg ccgccaagat cgccaggtac tgccacctgc acaacgtgaa catctgcatc     2040

ggcgagaacc tgtccttcca gcaggactcc gacaacatct ccaaggacaa ctccctggtg     2100

aggctgttct cctccaagtc catcgccaac tacatgaagc tggccatgga gaagttcggc     2160

atcgccttca tcgactccgc cgacccgtcc ggcacctcca agaccgaccc ggtgaccggc     2220

aacatcggct acaggaacaa gttcgacaag aggaagctgc acgtgatcag gaacggcaac     2280

tggggctggg tggactccga catcgccgcc tccctgaaca tcctgatcag gggcatcaac     2340

aggtccatcg tgccgtacaa gttcttcgtg ggcaagaaga agcaggagtc caagaggctg     2400

aaccacttcc tgaacaagat cttcggcacc accaaggtgt tcttctacga ggaccagttc     2460

ggcttcgcca acccgtccct gtccaagaag gagggcgaga acctgatcgc caaccagtac     2520

ctgtactaca gggagggcaa gttcgtgacc cagaagatcc acaggcagat cgaggacgac     2580

ttcaagaaga tcgacttctc caacaccccg gaggtgaacc tgatcccgtc cggcgtgaag     2640

ctgaagaact tccagttcga gtga                                            2664


<210>  22
<211>  2766
<212>  DNA
<213>  ˹

<220>
<223>  Cas12h.2

<400>  22
atggccacca ggtccttcat caggaccggc aacctgaagg ccaagaacac cgccgaggag       60

gtgatgcagt ggtacgccga cctgcagtcc gactacaggt ccttcctgaa cctgttcttc      120

ggctggatgg ccatcggcta cggcaccaac gccgaggacg aggtgttcta cacctccaag      180

gaggagtccg agaggctgag gtccctgacc atcggcgacg ccaagaagga gcagctggcc      240

gtgtccttca tcgagctgct gctgaagggc ggcgagaacg cctcctcctg ctacaacgtg      300

ttctacagga actacaagtc cctgggcaag gccaagctga cccagaagaa gaacgacttc      360

ctgtccgccc tgccgctgct ggacgagaac aagatcaagg agtacttcaa gaccgacgag      420

cagctgtccc agatctgcat cgaggagtgg ctggagtacg gcgtgaagaa cctgccgctg      480

ccggagatct gggccgaggt gtccccgagg ctggcctcca tcgagaggtc cctgggcgtg      540

gacctgaggc tggccttcgg cctgtcctgc atcaggtcca gggactgcaa ctactgcagg      600

atcctgatcg agatggtggg cagggacctg aggtccatct tcgagaagta caacaaccac      660

ctgctggaga ccgagaagat caagctgtcc atgaacgaca agcagggccc ggtgtacgac      720

tccatctgct gcttcgccgc cgagctggag tccaagaact ccggcctgac caagtacgtg      780

ctgaccaagg gcatcgacca cgtgaagaag ggcaccggcg agaagaccga catcaggctg      840

gccgtgaagg agctgaagaa gaacaagtac aggatcctga tcgagtcctc ctactccgag      900

atcatgtccg cctactcctg ctggaggacc aagaagcagc tggagaagag gaagctgtac      960

ccgtgcttcg acccgaacag gaacgactac aaggtgccgg tgggccaggg ctccctgggc     1020

aacttcaccg tgtccgtgga ggactccggc gacgtgctga tcgagatcgt gggcgtgggc     1080

gtgatcaggt gcgccgcctc ctgctacttc tccggcatcg tgttcgacga gatcaggaac     1140

aagaacggca ggaccggcta ctccctgaac ttctgccaca agtccatctc caagggcaag     1200

aaggccgtga aggccgcctc ccacaccggc gacaagatct ccggcgtgct gaaggagatc     1260

ggcctgagga acaccgactc cggcttcttc gtgtccctgc cgtactccat ccaccacgac     1320

gagaagaact tcaagatcgc cgagttcttc atgtccgcct gcccgaagaa ggagaacgtg     1380

gagaacctgc cggacaagat cgtggtgggc gccatcgacc tgaacgtgtc caacccggtg     1440

gccgccgtga aggccgtggt gtacagggac gacaagtccg gccagctgaa cgccctggac     1500

tacggctccg gcaacctgat caagaagccg ttcatgctgg tggccaacgg cccgaggatc     1560

aagaacctga tcgagatcag ggacgacgcc aggagggtga tcggcgccat cagggagttc     1620

aaggtgtcca acgccgtgaa ggagcacgtg ggcgaggaca ccagggactt cctgatcctg     1680

tgcggcgaca ccaagtcctc ctccaccagg tacctgatcc agtcctgggt gaagaagatc     1740

aactccaggc tgaggaagat caagttcgag atgaggtccg gcggctacag ggactgcgcc     1800

gacaacatca ggctgatcga ggccatggac cagtgcgcct ccatggccga gtcctacaac     1860

aggatccacc tgaagtccgg cgagaagctg gtgaaggtgg ccaagttcga caagtccagg     1920

gccaacttca ggaacttcgt gctgaggcag ctggcctcca agatcgccaa cgagatgaag     1980

gactgcaacg tggtgttcgg cgaggacctg gacttcatct tcgactccga caagaacaac     2040

aacgccctgc tgaggctgtt ctccgccgcc accctgctga agtacatcat cgaggccctg     2100

gagaagatcg gcgtgggctt cgtgaaggtg gccaagaacg gcacctccca gtccgacccg     2160

gtgacctcca acccgggctg gagggacgac aagaacaagt ccaggctgta cgtggtgagg     2220

gacaagcagc tgggctggat cgactccgac ctggccgcca ccatgaacat cctgatccag     2280

ggcctgaacc actccgtgtg cccgtacaag ttctacgtga aggagtacga gaacaagccg     2340

aactccaccc aggactccat caacgccatc aagaagccgg aggaggccat cggcaagagg     2400

atcaagaggt tcttcaacct gaagtacggc tcctccgtgc cgaagttcgt gtccgacgac     2460

aggggcaggg tgaccttcgc caagaagatc gactccaccc agaccaggct gatcaaccag     2520

ttcgtgtacg cccactcctc ctgcatcgtg acctgcgagc tgcacaacga gatggtgaac     2580

aagatcaagc agctggccgt ggagaagccg aactgccagg agttcgacgt gacctgcgac     2640

ccggacggca ggtacaacaa cttcgccctg ccggaggtgc acgactcctc caaggacgtg     2700

ggcgccaagg ccctgaccac caaggacgtg gacttcaaga ccatcctgaa ggaccacacc     2760

gcctga                                                                2766


<210>  23
<211>  3894
<212>  DNA
<213>  ˹

<220>
<223>  Cas12w.1

<400>  23
atgggcaaga acgagaacaa gtaccagctg tccaagaccc tgaggttcgg cctgaccctg       60

aaggagaaga tctccaacaa cgagaagacc ccgtaccagt cccactccca gttcagggac      120

ctgatcatcc tgtccgagaa caggatcagg gagggcatct ccaccccgca gaacagggac      180

ctgccgtcct tcatccacag gatccagaac tgcaccgact tcatcaacga cttcatccac      240

gactggtgga tgatcctgat gcacaccggc cagatcgagc tggacaagga ctactacaag      300

tccctgacca agaaggtggg cttcgtgggc ttctggtaca aggagaacaa gaagaagggc      360

ggcaagacca agcagccgca ggccaggaac atcccgatgg gcgagctgag gcacctgtgc      420

ccgcagaaca ccaaggagtg cgccacctac atcaccgact actggaagga cctgctgatc      480

accgccacca acaagctgta cgagtcctcc gagcagcaga agaagttcat caaggccatg      540

gagcagaaca ggaccgacaa caagccgaac gagatcgacc tgaagaagtc cttcctgtcc      600

ctggtgtccg tgaccatgga gctgctgaac ccgatcctga acggccagat cctgttcaac      660

aagatggaca ggctggacat gtccaagaag tccgacaacg acttcatcga cttcgtgaac      720

gaccacgaga ccgtgaggga gctgaacaac gacatcgagg agatcatcgc cgacttcaag      780

gagaacggca acaacgtgaa ctactgcaag gccaccctga acccggacac cgccctgaag      840

cagcacaaca acaacatccc gaacgacatc gccaccgacc tggaggagct gatgatggac      900

tccatcgtgg gcaactacga cgacgtgaac tccttcatgg acaactacgt gtccaacctg      960

tccgccaagg acaagatcaa gaagatcaag gactccaaca tctccctgat ctacagggcc     1020

atcctgttca agtacaagat gatcccggcc aacgtgagga gggacatcgc ccagggcatg     1080

gccaagaagc tgaacaagga cgaggagaac atctactcct tcctgtgcga gttcggcacc     1140

ctgaggaccc cgcagaagga ctacgccgac ctgaaggaca aggactcctt caacctggac     1200

aactacccgc tgaaggtggc cttcgacttc gcctgggagg gcctggccaa ggcctggtac     1260

cacgaccagt ccgacttccc gatcgacccg tgcagggact tcctgcagga gaacttcgac     1320

gtgaacctgg aggaggacca ggaggacgag tacttcctgc tgtacgccga cctgatcgag     1380

ctgaacgccc tgctgtccac cctggacaag ggcaacccgg ccgacccgga ctccatcaag     1440

aacgaggccc tggagatggt ggagtacatc aactggaact ccctggacaa gaagaacggc     1500

aactactaca agaagatcat caagaacagg ctgaagtcct ccaagggcaa cgagacctac     1560

gagaggatca agaaggagat ctccatgtcc aggggcaggc tgaagaacaa gatcgagaag     1620

tacgacgacc tgacctccca gtacaagagg atcgccatgg acctgggcaa gaagttcgcc     1680

tccctgaggg acaagatcat cgccgccaac gaggacaaca aggtgaccca ctacgccatg     1740

atcctggagg actccaactg cgacaagtac ctgctgctgc agaaggtgtc caacaacatc     1800

taccactgca tgtcctacga ctcctccgac ccgaaggcct actacgtgga ctccatcacc     1860

tcctccgcca tcgccaagat gatcaggaag gagaccaacc cgtccaagat cagggagtac     1920

gccgagctgg aggagaagga gagggagagg aggaacgtgg acgactggtg caggttcatc     1980

tccaagaagg agtacgacag gaggtaccag ctgaacatca acaacggcct gtccttcgag     2040

gccctgaaga aggagatcga ctccaagtcc tacatcctgg tgaagaagaa catctccgtg     2100

gactccatca gggagctggt ggagaacgag ggctgcctgc tgttcccgat cgtgaacaag     2160

gacctgacca aggagaggaa gaccaccgag gacaaccagt tcaccaagga ctggaacatg     2220

atcttctccg gctccgagac caactggagg ctgaccccgg agttcagggt gacctacagg     2280

aacccggtgc cgggctaccc gaacgacaag ttcggctcca agaggtactc caggttccag     2340

atgaacgccc acttcgtgtg cgacttcatc ccgtcctcca actcctacac ctccaacagg     2400

gagcagatcg ccatcttcaa ggacgagggc gagcagaaga agagggtgga ggagttcaac     2460

aggaccctgt ccaacatcaa ccagaagttc tacgtgatcg gcatcgacag gggccagaag     2520

gagctggcca ccctgtgcgt ggtggaccag gacaagaaga tccacggcga cttcaagatc     2580

tacaccagga agttcaactc cgagaggaag cagtgggagc actactccct ggagggcgag     2640

aagggcacca ggaacatcct ggacctgtcc aacctgaggg tggagaccac catcatcatc     2700

gacggcaagc cggagaggag gcaggtgctg gtggacctgt ccgaggtgct ggtgaaggac     2760

aaggagggca actacaccaa gccgaacaag atgcagatca agatgcagca gatggcctac     2820

gtgaggaagc tgcagttcca gatgcaggcc aacccgaccg aggtgctgga gtggtacgag     2880

cagaacccga ccgaggagct gatcatcaag aacctggtgg acaaggagaa cggcgagaag     2940

ggcctgatct ccttctacgg caccgccctg gtggagctgg accagaccct gccggtgtcc     3000

aagatcaagg agatgctgga ggagttcaag atcctgaagc agagggagtc caagaaggag     3060

aacgtgcaga aggagctgaa caacctgacc cagctggagg ccgtggactc cctgaaggcc     3120

ggcatcgtgg ccaacatggt gggcgtgatc tcctacatcc tgaagaccct ggactacaac     3180

gcctacatct ccctggagga cctgtccacc gtgcagtcct ccaccgagtt cgcctccggc     3240

atctccggcg ccatcaccaa gatgtccagg gaggagggca ggaggatcga cgtggagaag     3300

tacgccggcc tgggcctgta caacttcttc gagatgcagc tgctgaggaa gctgcacagg     3360

atccagaccg acaacggcaa catcctgcac ctggtgccgg ccttcagggc ccagaagaac     3420

tacgaccaca tcatggtggg caaggagaag atcaagaacc agttcggcat cgtgttcttc     3480

gtggacgccg ccgccacctc catcaagtgc ccgaggtgcg gcgccgtgaa cgaggacaag     3540

ttcaacccgg acaagcagaa gtacccggac gccgagaagg gcccgaagct gaggaacagg     3600

aaggagcagt ccggcaagaa ggtgtgggtg accagggaca aggaggacga cgacaggatc     3660

aagtgctact gctgcggctt cgacaccaag gagaagaacg agggcaaccc gttcatgtac     3720

atcaagtccg gcgacgacaa cgccgcctac ctgatctccg acctgggcgt ggagtcctac     3780

aggaaggcct acgagctggc cgccaccgtg gtggaggaca ggaagaagac cctgaccaac     3840

aacctgaacc agtccaacta caagatcagg ttcctgtggc acaccatgta ctga           3894


<210>  24
<211>  3774
<212>  DNA
<213>  ˹

<220>
<223>  Cas12w.2

<400>  24
atggacgccg acaagaccac caaggccatc aacgagtacc agacccagaa gaccatcagg       60

ttcggcctga ccgccaccaa ccagaacctg tactccgagg agatcatgaa gctgctgaac      120

atctccgagg agaggatcat caaggagaag gtgaaggtga acaacgacac cgacaagacc      180

aaccagctga ggggctgcct ggtgcagatc aagaagtacc tgaagacctg ggagaacatc      240

tacgcccaga tcgacttcct ggccatcacc aaggactact acaaggtgat ctccaagaag      300

gccaggttcg acttcgacaa gggcaacggc tccgagatca agctgtcctc cctgcagtcc      360

acccacaaca agaagaagag gtaccagtac atcatcgact tctggaagga gaacctgagg      420

aagaccgaga acctgtacag gaagtccgac gacctgctga agatcttcga ggaggccaag      480

aaccagaaca gggacgacaa gaagctgaac aaggtggagc tgaggaagac cttcctgaac      540

ctgttcaccc tggtgaacga gtccctgaag ccgctgatcg agggcaacct gttcatcgtg      600

aacgacgaca agatcgacga gaagaactcc aagcacaact acgtgttcta cttcatctcc      660

aagaccgagg agaggaggct gctgtacgac aacatctgca ccctgcagga ctacttcaag      720

aacaacggcg gctacgtgcc gttcggcagg gtgaccctga acaagtggac cgccctgcag      780

aagttcaaca acagggacat cgagatcaac aggatcatca aggagctgaa gatcaacaac      840

atctccaccc agaagaccga ctacaagtac aacgacttca ccgagaactt caaggagaag      900

aaggacgaga acggcaaggt ggtgaagaac tccgccggca acatcatctg ggacctgaag      960

gccaacgcca agtccgtgat cgagatctgc cagttcttca agtacaagaa ggtgccgatc     1020

aacgccaggc tgaacctggc caagaggctg atcaaggaca acaagctgaa gaaggagcag     1080

gagaacacct tcctgtccga gttcggcgtg ctgaagaccc cggccttcga ctacgccagg     1140

gacaaggaga acttcaacct gaccaactac ccgctgaagg tggccttcga ctacgcctgg     1200

gagaactgcg ccaaggacaa gtacgagaag atcccgttcc cgaaggagca gtgcgagagg     1260

tacctgcaga ccgccttcga gatcgacgcc accaaggacg agaacaagaa gctgatcgac     1320

acccacctga acaagtacgc cgacctgctg cagttcaaga tcctgctgga gaggttcaag     1380

gccgagttcc acaagaccaa cgaggagacc aacaagaaca acatccagaa gctgaggaac     1440

gtgttctccg gcctggacta ccacggcgac aacaggctga acaagaacca gatccagaag     1500

gccatcgagg cctggttcga caacaaggag cagaacatcg gcaagaagaa ggagaacgag     1560

aagctgctga ccgagaacga gaagaacaac ttctccctgt ccatgcagat catcggccag     1620

gagaggggcg gcctgaagaa cggcatcccg aagtacaagg agctgaccga gatgttcaag     1680

gtgtgcgcct ccaagttcgg caagcagttc gccgacctga gggactactt caacgaggcc     1740

tacgaggtgg acaagatcaa gtacagggcc tggatcatcg aggacgacaa gaagaacagg     1800

ttcgtgctgt tcgtgaacaa ggagaaggcc ttcgacctga cctccgagga gggcgacctg     1860

tggttctacg aggtgaagtc cctgacctcc aagtccctgg tgaagttcat caagaacagg     1920

ggcgcctacc cggacttcca cgacgtgaag aactccttcc actactcctc catcaagaag     1980

gactggcaga actacaagaa cgacccggag ttcctggaca agctgaagga gtgcctgaag     2040

aactccaaga tcgccaagga ccagaagtgg gccaagttct gctgggactt caagcagtgc     2100

gacacctacg agaagctgga gaaggaggtg gacaggaagg gctacaagct ggagggctgc     2160

aagtccgagc cgaagaccat ctccctgacc cagctgaccg actgggtgga gaacaaggac     2220

tgcttcctgc tgccgatcgt gaaccaggac atcaacaagg gcgacaagag gaccaagaac     2280

cagaaccagt tcaccaagga ctggttcgac atcttcgaga acaagaagag gctgcacccg     2340

gagttcaaca tcttctacag gttcccgacc aaggactacc cgaacaccaa gttcaagaac     2400

ggcaccgaga agaccaagag gtactccagg ttccagatgc tggcctactt cggctgcgag     2460

gtgatcccgt ccggcaacca cctgtccaag aaggagcaga tcgccatctt caacaacgac     2520

aagaagcaga aggaggaggt ggagaagtac aacaagtcca tctcctccga ctgcgactac     2580

gtgatcggca tcgacagggg catcaagcag ctggccaccc tgtgcgtgct ggacaagaac     2640

ggcgtgatcc agggcgactt ccagatcttc accaggacct tcaacaagca gaccaagcag     2700

tgggagcaca aggagctgga gcagaggaac atcctggacc tgtccaacct gagggtggag     2760

accaccatca ccggcaagaa ggtgctggtg gacctgtcca agatcaagga cgacgagggc     2820

aactacacca acctgaagca gaccatcaag ctgaagcagc tggcctacat cagggagctg     2880

cagtacgcca tgcagaccag gccggacgac ctgctggact tcgtgaagtc catcaactcc     2940

gccaacgaca tcaccgccga gaacatcaag cacttcatct ccccgtacaa ggagggcaag     3000

aactacgacg acctgccgaa ggtggagatg ttcaacctgc tgaaggagtg gggcaacgcc     3060

gacgagaacg gcaagaggaa gatcgccgag ctggacccgg ccgacaacct gaagtccggc     3120

atcgtggcca acatggtggg cgtggtggcc ttcctgtgcg agaactacaa ctacaaggtg     3180

aggatcgccc tggaggacct gaccagggcc tacggcatcc agaaggacgc cctgaacggc     3240

accgccatct accagaacga cgaggacttc aaggagcagg agaacaggag gctggccggc     3300

gtgggcacca tgcagttctt cgaggtgcag ctgctgagga agctgttcaa gatccaggtg     3360

gacaagaacc tgcacctgat cccggccttc aggtccgtgg acaactacga gaagatcgtg     3420

aggagggaca agcagaactc cggcgacgag ttcgtgaact acccgttcgg catcgtgtgc     3480

ttcgtggacc cgaagtacac ctcccagcag tgcccgtact gcaacaacac ccacaagcac     3540

aagaagaacg acaccgagac cggcaagaag gccttctaca ggaacaaggg cgagaacaag     3600

aactccctgc tgtgcgagaa gtgcggcgtg tccaccatcg agggcgagga gaccctgtcc     3660

tccaagaacg acaacaagaa gcagttcaac atccactaca tcaccgacgg cgaccagaac     3720

ggcgcctacc acatcgccaa caaggtggtg atcaacttcc agaaggactc ctga           3774


<210>  25
<211>  3036
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.1

<400>  25
atggactacc agcagtacga gttcaccagg accatcaggt tcaacctgtc cggcgacgac       60

aagagggccc tgatgctgga cctgctggac gacacccagg agggcatgct ggccgccttc      120

caggagacct acaagaacct gctgttcgcc ttccaggagg ccatcctgag ggccgacggc      180

tccggcaacc tgagggtggg caggctggag atcaagaagt cctggctgag gcagtacgcc      240

agggagtact tctacgccct gtccgaggac gagaggaggt gcaagaacaa gttccaggcc      300

aagctgttcg acagggtgct gtccgactgg ctggagagga acaacgagct gctgcagagg      360

ctgaacaaca tcctgtccct gccgcaggag tccaagaccg gcgcctccga cctgtccctg      420

ctggtgaggc agctgaaggg cgccgagtac ttctacttca tcagggactt cacccagtcc      480

ggcatcatca acgacaagga ctccgacgag cacatcaaga acctggccgg catcgtggag      540

aagttcgaga ccctgctgga caaggtgctg ttcctgaccg ccccgaactc ctcccagggc      600

gtggagacca ccagggcctc cttcaactac tacaccgtga acaagatctc caagaacttc      660

gacgagaaca tcaagaaggc caacggcagg ctgtgctcct cctaccagaa ctccatgaac      720

gaggagctgc tgaggaaggt gggcttcctg aagtacctga aggacgagta cagggccgag      780

ctgcagaacg tgtccctgaa ggacctgtac gaggccctga agaagttcaa gtcccagcag      840

aagaccgcct tcatccaggc cgtgcagaag aacaagtccg agaaggagct gatgagggag      900

ttcccgctgt tcaacggcaa gcagccggac accctgcaga agttcatcct ggagaccgac      960

aagatcaaga ggggcgccta cttccagaag tggggcttcg acaactacat ctccttctgc     1020

aacaagatct tcaagccggt ggccatggag accggcacca ggaaggccaa gatcagggcc     1080

ctggagcagg agaagatcga ggccaggctg ctgcagtact gggcccacat cctggtgaag     1140

gacggcaagt acttcctgct gctgatcccg aaggagaaga tgggcgaggc caaggtgttc     1200

ttcgccaggc tgtccgacca ggagggcggc gagtacaccc tgtacgcctt caactccctg     1260

accctgaggg ccctgaagaa gctgatcagg aggaacctgg gcaaggagca ggtgaggctg     1320

tccgccggcg acgccgacgc catcgccctg tgccaggagg tgctgagggg caggtaccac     1380

cagctgaagg acctggacct gtccggcttc gagaaggaga tcgccgagat cgccaacacc     1440

cagtacgaga acgaggagga gttcaggatc gccctggagc aggtggccta ctacctgtcc     1500

gagaggaaga tgaacgagga gtccatcgag tacctgaaga agaacctggg cgccatcctg     1560

ctggagatct cctcctacga cctggagagg aacatcaccg gcgagtccaa ggagcacacc     1620

aggctgtggt ccgacttctg gaacccgaac aacaagaagg agtgcttctc caccaggctg     1680

aacccggagc tgaggatctt ctacaggccg ccgagggagc agaaggaccc gaagaagcag     1740

aagaacaggt tctccaagga ccacctggcc gtggccttca ccatcgccca gaacgccgcc     1800

aggaagagga tggagacctc cttcgccgag gagaaggacc tggtggagca ggtgaagaag     1860

ttcaacgagg aggtggtggg caagttcatc gacgagaagt ccgacaacct gtactactac     1920

ggcatcgaca ggggccagca ggagctggcc accctgtgcg tggtgaggtt ctccaaggag     1980

cactacgagg ccatgctgga ggacaacttc atcaagaagt tctccaagcc gatcccggcc     2040

cagatcaccg cctacaggat caaggacgag cacatgtcct acaggaagaa catcaccagg     2100

gacctgaagg gcaacgagac cgaggagatc ctgttcaaga acccgtccca cttcatcgac     2160

gaggtggaga acttcgagga ggtgtccacc ccgtgcatcg acctgaccac cgccaagctg     2220

atcaagggca agatcatcct gaacggcgac atccagacct acctggccct gaagaaggcc     2280

aacggcaaga ggcagctgtt cgagaagttc gccaagatcg acgactccgc caagatcgag     2340

ttcgacgact ccgagggcag gttccaggtg aagtccaagg ccaccgagag ggaggagtac     2400

cagttcctgc cgtactacgg cccggagcag gagaacatct ccccgaggga ggacatgagg     2460

agggagctgc aggcctacct ggacaagctg aggtcctccg agtccttcga ggaggacatc     2520

tccatcgaga agatcaacca cctgagggac gccatcacct ccaacatggt gggcatcatc     2580

gccttcctgt tcaccgagta cccgggcatc atcaacctgg agaacctgca ctccagggag     2640

aacatcgaga agaactggag gaagaacaac gaggacatct ccaggaggct ggagtggggc     2700

ctgtacaaga agttccagaa gatcggcctg gtgccgccga ggctgaggca gaccgtgctg     2760

ctgagggaga acgagaccga gaggcaggag aagctgaacc agttcggcat catccacttc     2820

atcccgaccg agaagacctc cgccaggtgc ccgtactgcg gcgagaacac cccgatgaag     2880

cagaggaacg aggacaagtt caagctgcac gcctacatct gcaggtccaa cgaggagaac     2940

tgcggcttcg acaccaggga gccgaagtcc ccgctggagt tcatcaagaa ctccgacgac     3000

gtggccgcct acaacatcgc caagaagagg ctgtga                               3036


<210>  26
<211>  3204
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.2

<400>  26
atgaagaacg gcatcaacct gttcaagacc aagaccacca agaccaaggg cgtggacatg       60

gagaagtacc agatcaccaa gaccatcagg ttcaagctgc tgccggacaa cgcccacgag      120

atcgtggaga aggtgaagtc cctgaagacc tccaacgtgg acgagctgat ggacgaggtg      180

aagaacgtgc acctgaaggg cctggagctg ctgttcgccc tgaagaagta cttctacttc      240

gacggcaacc agtgcaagtc cttcaagtcc accctggaga tcaaggccag gtggctgagg      300

ctgtacaccc cggaccagta ctacctgaag aagtcctcca agaactccta ccagctgaag      360

tccctgtcct acttcaagga cgtgttcaac gactggctgt tcaactggga ggagtccgtg      420

tccgagctgg ccatcatcta cgagaagtac aagatctgcc agcaccagag ggactccagg      480

gccgacatcg ccctgctgat caagaagctg tccatgaagg agtacttccc gttcatctcc      540

gacctgatcg actgcgtgaa cgacaagaac tccaacaaga ccttcctgat gaagctgtcc      600

gaggagctgt ccgtgctgct ggagaagtgc aactccaggg ccctgccgta ccagtccaac      660

ggcatcgtgg tgggcaaggc ctccctgaac tactacaccg tgtccaagtc cgagaagatg      720

ctgcagaacg agtacgagga cgtgtgccag tccctggaca agaactacga catcaccgag      780

atgaaggtga tcctgtacaa ggagaagctg gacaacctga acttcaagga cgtgaccatc      840

gccaacgcct acaacctgct gaaggagaac aaggccctgc agaagaggct gttctccgag      900

tacgtgtccc agggcaaggt gctgtccctg atcaagaccg agctgccgct gttctccaac      960

atcaacgaca acgacttcga gaagtacaag gagtggtcca acgagatcaa gaagctggcc     1020

gacaagaaga acaccttctg caagaagacc cagcaggaca agatcaagga catccagaac     1080

aagatctccg agctgaagaa gaagaggggc gccctgttcc agtacaagtt cacctccttc     1140

cagaagcact gcgacaacta caagaaggtg gccgtgcagt acggcaagct gaaggccagg     1200

aagaaggcca tcgagaagga cgagatcgag gccaacctgc tgaggtactg gtccgtgatc     1260

ctggagcagg aggacaagca ctccctggtg ctgatcccga agaacaacgc caaggacgcc     1320

aagcagtaca tcgagaccat caacaccaag ggcggcaagt acatcatcca ccacctggac     1380

tccctgaccc tgagggccct gaacaagctg tgcttcaacg ccgtggacat cgagaagggc     1440

cagatggtga gggagaacac cttctaccag ggcatcaagg aggagttcga gaggaacaag     1500

atcaactgcg acaaccaggg cgtgctgaag atccagggcc tgtactcctt caagaccgag     1560

ggcggccaga tcaacgagaa ggaggccgtg gagttcttca aggaggtgct gaagtccaac     1620

tacgccaggg aggtgctgaa cctgccgtac gacctggagt ccaacatctt ccagaaggag     1680

tacaccaacc tggaccagtt caggcaggac ctggagaagt gctgctacgc cctgcactcc     1740

aagatcggca aggacgacct ggacgagttc accaggaggt tcgaggccca ggtgttcgac     1800

atcacctcca tcgacctgaa gtccaagaag gagaagacca agaccaccgg cgagatgaag     1860

aagcacaccc agctgtggct ggagttctgg aagggcgcca tcgagcagaa cttcgccacc     1920

agggtgaacc cggagctgtc catcttctgg agggccccga agtcctccag ggagaagaag     1980

tacggcaagg gctccgacct gtacgacccg aacaagaaca acaggtacct gtacgagcag     2040

tacaccctgg ccctgaccat caccgagaac gccggctccc acttcaagga catcgccttc     2100

aaggacacct ccaagatcaa ggaggccatc aaggagttca acatgtccct gtcccagtcc     2160

aagtactgct tcggcatcga caggggcaac gccgagctgg tgtccctgtg cctgatcaag     2220

aacgagaagg acttcccgtt cgagaagttc ccggtgtaca ggctgaggga cctgacctac     2280

cagggcgact tcaaggacaa gcacgaccag atgaggtacg gcgtggccat caagaacatc     2340

tcctacttca tcgaccagga ggacctgttc gagaagaaca acctgtccgc catcgacatg     2400

accaccgcca agctgatcaa gaacaagatc gtgctgaacg gcgacgtgct gacctacctg     2460

aagctgaagg aggagaccgc caagcacaag ctgacccagt tcttccaggg ctcctccatc     2520

aacaagaact ccagggtgta cttcgacgag gacgagaacg tgttcaagat caccaccaac     2580

aggaaccaca acccggagga gatcatctac ttctacaggg gcgagtacgg cgccatcaag     2640

aacaagaacg acctggagga catcctgaac gagtacctgt gcaagatgga gaccggcgag     2700

tccgagatcg tgctgctgaa cagggtgaac cacctgaggg acgccatctc cgccaacatc     2760

gtgggcatcc tgtcctacct gatcgacctg ttcccggaga ccatcgtggc cctggagaac     2820

ctggccaagg gcaccatcga caggcacgtg tcccagtcct acgagaacat caccaggagg     2880

ttcgagtggg ccctgtacag gaagctgctg aacaagcagc tggccccgcc ggagctgaag     2940

gagaacatcc tgctgaggga gggcgacgac aagatcgacc agttcggcat catccacttc     3000

gtggaggaga agaacacctc caaggactgc ccgaactgca ggaagaccac ccagcagacc     3060

aacgacaaca agttcaagga gaagaagttc gtgtgcaagt cctgcggctt cgacacctcc     3120

aaggacagga agggcatgga ctccctgaac tccccggaca ccgtggccgc ctacaacgtg     3180

gccaggaaga agttcgagtc ctga                                            3204


<210>  27
<211>  3276
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.3

<400>  27
atggccggca ccccgtacac cggccacgtg gcctgcaagt actgcaagat cacctcctgg       60

gccacctacg acaggatcaa gatcaacaag atcaacatga accagtcctt catcaacggc      120

cagaacttct acgagctgag gaagaccatc aggttcgtgc tggacccgaa gaccctgaag      180

aggccgtaca ccccgtcctc cgacgaggtg aacctggagg agcagctgaa caacttcatc      240

gagaagtacc agcagggcat caacgacttc aagtacatcg tgtacttcgg cccgaagacc      300

gccgagacca aggagctgaa caagaagatc tccatcaagc actcctggct gaggaactac      360

accaagtccg agttctactc catcaaggac aagctgatcc agctggacta caacggcaac      420

aaggcctcca tcggcaactc caacctgaag ttcctgaacg agtacttcga gaactggatc      480

tccgagaacc aggagtgcgc cgacgccctg aagaactgca tcaacgcccc ggccgagaag      540

cagaagagga agtccgaggc cgcccactgg gtgaggaagc tgaccaagag gtccaacttc      600

gagtgcatct tcgagctgtt caacggcaac atcgaccaca agaactccaa cgacgacatc      660

gagaagatca agcactgcct gaacgagtgc aagaccctgc tgacctccct ggagaagatg      720

ctgctgccgt cccagtccct gggcatggag atcgagaggg cctccctgaa ctactacacc      780

atcaacaaga agccgaagaa ctacgacgag gacatcgccc agaaggcctc cgccctgaac      840

gaggcctacc agttcaaggc cgacgacaag gccttcctga acagggtggg cttctccgac      900

gacggcgtgc cgatcaacga gctgaaggag gccatgaaga agttcaaggc cgaccagaag      960

tccaagttct acgagttcgt gaaccagaag aagtcctact ccgacctgaa gaagaacgac     1020

gacctgaagc tgctgaacga catctccgag gaggacttca acaagttcaa ggagacccag     1080

gacaagatga ccaggggcaa gcacttccag ttctccttcc cgaactacaa gaagtccgag     1140

aagaacttct gcgacctgta caagaacgtg gccgtggcct tcggcaagat cagggccgac     1200

atcaaggccc tggagaagga gaggatggac gccgagaagc tgcagtgctg ggccgtgatc     1260

ctggagaagg acaaccagag gtacgtggtg accatcccga gggacgccaa caacaacctg     1320

accaacacca agcagtacat cgacaacctg cagaacgagg agaacgacca gtggatcctg     1380

tacgccttcg agtccctgac cctgaggtcc ctggacaagc tgtgcttcgg cctggacaag     1440

aacaccttca tcccggccat caccggcgag ctgtaccaga agaacaactc cttcttcgag     1500

aagggcctgc tgaagaggaa ggaccagttc tcccagaacg gcaccgacct ggccgccttc     1560

tacaagaccg tgctggagct ggactccacc aagaagatgc tgggcatcaa caagtacgcc     1620

gacttcaagg ccttcatctc caaggagtac accgccctgg aggacttcga gaagaccctg     1680

aaggagacct gctacttcaa gaagagggtg ttcatctccg aggacaccaa gaacaagctg     1740

atcaacgact accagggcaa cctgtacaag atcacctcct acgacctgga gaaggacgac     1800

tccgaggccc tgggcaccct gatcaacaag aagcagttca acagggcctc cccggagatc     1860

cacaccaaga cctggctgga cttctggacc gccgacaacg agaccgacaa gtacccgatc     1920

aggctgaacc cggagttcaa gatctccttc gtggagaagc aggacaagga cctgaacatg     1980

aggaacctgg gcctgctgaa caagaacagg aggctgaagt cccagttcct gctgtccacc     2040

accatcaccc tgctggccca cgagaagaac gccgacctgc acttcaagaa gaccgacgag     2100

atccagacct tcatcaactc ctacaaccag gagttcaaca agaagatcaa gccgttcgac     2160

atctactact acggcctgga caggggccag aaggagctgc tgaccctggg cctgttcaag     2220

ttctccgaga acgagaaggt gtccttcacc aagcaggacg gcaccgtggg cgagtactcc     2280

aagccgaagt tcatcccgct ggacgtgtac cagatcaggg agggccagta cctgaccaag     2340

aacaagaagg gcaggctggc ctacaagtcc atcgaccagt tcatcgacga cgagaaggtg     2400

atcgagaagc tgccggtgaa ctcctgcctg gacctgtcct gcgccaagct ggtgaagggc     2460

aagatcatcc agaacggcga cgtggccacc tacctggagc tgaagagggt gtccgccctg     2520

aggaagatct acgagaacac caccaggggc cagttcaaga ccgacaggat cggcttcaac     2580

aaggacaagg gctgcctgtt cctggacatc gagaacaggg gcaagctgga gaacaacaac     2640

ctgtacttct acgacaacag gttcgccgag atcctgtccc tggactccat catcaaggag     2700

ctgcaggact actacaacga ggtgaagaac aagcagaaca tcgagttcat ctccatcgac     2760

aagatcaacc acctgaggga cgccctgtgc gccaacgccg tgggcatcct ggcccacctg     2820

cagaagaccc acttcggcgt gatcgtgttc gagggcctgg acgccaggca caagaacaag     2880

gagaccaccg agttcgccgg caacctggcc tccaggatcg agaggaagat cctgcagaag     2940

ctggagaccc tgtccctgat cccgccgcag cacaggcaga tcatcgacct gcagaactcc     3000

aagcagatca agcagaccgg cgccgtgctg tacatcgagg agaagggcac ctccgccaac     3060

tgcccgcact gcgagaccgc caacccggac aagtccgaga agtggctggc ccacaactac     3120

aagtgcaaga actccaactg caacttcgac gcctccgaga tctccaagag gaaggacctg     3180

atcggcctgg acaactccga ctccgtggcc acctacaaca tcgccaagag gggcctgctg     3240

gagatgaacc agaagatcga gcagtccaag gtgtga                               3276


<210>  28
<211>  3174
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.4

<400>  28
atggagatcc aggagctgaa gaacctgtac gaggtgaaga agaccgtgag gttcgagctg       60

aagccgtcca agaagaagat cttcgagggc ggcgacgtga tcaagctgca gaaggacttc      120

gagaaggtgc agaagttctt cctggacatc ttcgtgtaca agaacgagca caccaagctg      180

gagttcaaga agaagaggga gatcaagtac acctggctga ggaccaacac caagaacgag      240

ttctacaact ggaggggcaa gtccgacacc ggcaagaact acgccctgaa caagatcggc      300

ttcctggccg aggagatcct gaggtggctg aacgagtggc aggagctgac caagtccctg      360

aaggacctga cccagaggga ggagcacaag caggagagga agtccgacat cgccttcgtg      420

ctgaggaact tcctgaagag gcagaacctg ccgttcatca aggacttctt caacgccgtg      480

atcgacatcc agggcaagca gggcaaggag tccgacgaca agatcaggaa gttcagggag      540

gagatcaagg agatcgagaa gaacctgaac gcctgctcca gggagtacct gccgacccag      600

tccaacggcg tgctgctgta caaggcctcc ttctcctact acaccctgaa caagaccccg      660

aaggagtacg aggacctgaa gaaggagaag gagtccgagc tgtcctccgt gctgctgaag      720

gagatctaca ggaggaagag gttcaacagg accaccaacc agaaggacac cctgttcgag      780

tgcacctccg actggctggt gaagatcaag ctgggcaagg acatctacga gtggaccctg      840

gacgaggcct accagaagat gaagatctgg aaggccaacc agaagtccaa cttcatcgag      900

gccgtggccg gcgacaagct gacccaccag aacttcagga agcagttccc gctgttcgac      960

gcctccgacg aggacttcga gaccttctac aggctgacca aggccctgga caagaacccg     1020

gagaacgcca agaagatcgc ccagaagagg ggcaagttct tcaacgcccc gaacgagacc     1080

gtgcagacca agaactacca cgagctgtgc gagctgtaca agaggatcgc cgtgaagagg     1140

ggcaagatca tcgccgagat caagggcatc gagaacgagg aggtgcagtc ccagctgctg     1200

acccactggg ccgtgatcgc cgaggagagg gacaagaagt tcatcgtgct gatcccgagg     1260

aagaacggcg gcaagctgga gaaccacaag aacgcccacg ccttcctgca ggagaaggac     1320

aggaaggagc cgaacgacat caaggtgtac cacttcaagt ccctgaccct gaggtccctg     1380

gagaagctgt gcttcaagga ggccaagaac accttcgccc cggagatcaa gaaggagacc     1440

aacccgaaga tctggttccc gacctacaag caggagtgga actccacccc ggagaggctg     1500

atcaagttct acaagcaggt gctgcagtcc aactacgccc agacctacct ggacctggtg     1560

gacttcggca acctgaacac cttcctggag acccacttca ccaccctgga ggagttcgag     1620

tccgacctgg agaagacctg ctacaccaag gtgccggtgt acttcgccaa gaaggagctg     1680

gagaccttcg ccgacgagtt cgaggccgag gtgttcgaga tcaccaccag gtccatctcc     1740

accgagtcca agaggaagga gaacgcccac gccgagatct ggagggactt ctggtccagg     1800

gagaacgagg aggagaacca catcaccagg ctgaacccgg aggtgtccgt gctgtacagg     1860

gacgagatca aggagaagtc caacacctcc aggaagaaca ggaagtccaa cgccaacaac     1920

aggttctccg acccgaggtt caccctggcc accaccatca ccctgaacgc cgacaagaag     1980

aagtccaacc tggccttcaa gaccgtggag gacatcaaca tccacatcga caacttcaac     2040

aagaagttct ccaagaactt ctccggcgag tgggtgtacg gcatcgacag gggcctgaag     2100

gagctggcca ccctgaacgt ggtgaagttc tccgacgtga agaacgtgtt cggcgtgtcc     2160

cagccgaagg agttcgccaa gatcccgatc tacaagctga gggacgagaa ggccatcctg     2220

aaggacgaga acggcctgtc cctgaagaac gccaagggcg aggccaggaa ggtgatcgac     2280

aacatctccg acgtgctgga ggagggcaag gagccggact ccaccctgtt cgagaagagg     2340

gaggtgtcct ccatcgacct gaccagggcc aagctgatca agggccacat catctccaac     2400

ggcgaccaga agacctacct gaagctgaag gagacctccg ccaagaggag gatcttcgag     2460

ctgttctcca ccgccaagat cgacaagtcc tcccagttcc acgtgaggaa gaccatcgag     2520

ctgtccggca ccaagatcta ctggctgtgc gagtggcaga ggcaggactc ctggaggacc     2580

gagaaggtgt ccctgaggaa caccctgaag ggctacctgc agaacctgga cctgaagaac     2640

aggttcgaga acatcgagac catcgagaag atcaaccacc tgagggacgc catcaccgcc     2700

aacatggtgg gcatcctgtc ccacctgcag aacaagctgg agatgcaggg cgtgatcgcc     2760

ctggagaacc tggacaccgt gagggagcag tccaacaaga agatgatcga cgagcacttc     2820

gagcagtcca acgagcacgt gtccaggagg ctggagtggg ccctgtactg caagttcgcc     2880

aacaccggcg aggtgccgcc gcagatcaag gagtccatct tcctgaggga cgagttcaag     2940

gtgtgccaga tcggcatcct gaacttcatc gacgtgaagg gcacctcctc caactgcccg     3000

aactgcgacc aggagtccag gaagaccggc tcccacttca tctgcaactt ccagaacaac     3060

tgcatcttct cctccaagga gaacaggaac ctgctggagc agaacctgca caactccgac     3120

gacgtggccg ccttcaacat cgccaagagg ggcctggaga tcgtgaaggt gtga           3174


<210>  29
<211>  3477
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.5

<400>  29
atggagaact tcaagaacct gtacgaggtg aggaagaccg tgaggttcga gctgaagccg       60

tccaggaaga agaccttcgc cggcggcgac atcttcgagc tgcagaagga cttcgaggag      120

gtgcagaagt tcttcctgga catcttcgtg ttcgccatcg agcaggagaa gctgtaccag      180

gaggaggagg aggagggcaa gctgtccagg tacaccaaga tcgagttcaa gaagaagagg      240

gagatcaagt acacctggct gaggatctac accaagaacg agttctacga ctggaacggc      300

aagaacgaca aggagaagaa ctacgccctg tccaagatcg acttcctgga gaaggagatc      360

ctgaggtggt tcaacgagtg gcaggagctg accgtgaacc tgaagaacct gacccagacc      420

aaggagcacg agaaggagag gaagtccgac atcgccttcg tgctgaggaa cttcctgaag      480

aggcagaact tcccgttcat caaggacttc ttcaacgccg tgatcgacat ccaggagaag      540

cagggcaacg agtccgacga gaagatcagg aagttcaggg aggagctgag ggagatgaag      600

aagaacctga acacctgcgc caaggagtac ctgtcctccc agtccaaggg cgtgctgctg      660

cacaaggcct ccttcaacta ctacaccctg aacaagaccc cgaaggagta cgagaacctg      720

aagctgcaga aggagctgga gatcgacaac atcctgccga agaagatctg caagagggtg      780

aggtggaaca aggagaagaa gcaggaggac atcctgttcg agtgcaactc cgactggctg      840

gtggagatca agctgggcta cgacatccag aagtggaccc tggacgaggc ctaccagaag      900

atgaagacct ggaaggccga ccagaagtcc gacttcaacg agaagatcgg caacttcatc      960

gaccagtacc tgaagaaggg cttcatcgag gacctgatga acgagaacga gaagaagaac     1020

gccgaggcca tcctgaggga gttctccgtg ttcaagccga tcgagaactt ctacttctac     1080

gacttcctgg agaggaccaa ggagatcaag atcctgtcca accagaagaa caacatcctg     1140

cagaagtaca acaagaacgc caagtacttc gagaagatca tcacctacaa gatcaaggac     1200

aaggaggacc tgaccgagga cgagaaggag taccaggagc tggagaagtc catcgagaag     1260

aaggccaagg agaggggcaa gttcttcaac gccccgaagg agaaggtgca gacccagcac     1320

tacttcgagc tgtgcgagct gtacaagagg atcgccatga agaggggcaa gatcatcgcc     1380

gagatcaagg gcatcgagaa cgaggaggtg cagtcccagc tgctgaccca ctgggccctg     1440

atcgccgagg agggcgagaa gaagtccgtg gtgttcatcc cgaggaagaa cggcgaggag     1500

ctggagaacc acaagaaggc ccacgagttc ctgcagaagc aggagaagaa ggagttcggc     1560

gacatcaagt cctaccactt caagtccctg accctgaggg ccctggagaa gctgtgcttc     1620

aaggagaccg agaacacctt caccccggag atcaagaagg agaccaaccc gaaggtgtgg     1680

ttcccgaagt acaagcagga gtggaacgac gagccgcaga agctgatcaa cttctacaag     1740

caggtgctgc agtccaagta ctcccagaag tacctggacc tggtggcctt cggcgacctg     1800

aagtccttcc tggagacctc cttcgacgac ctgcagatct tcgagtccgg cctggagaag     1860

acctgctaca tcaaggtgcc gatctacttc tccaaggagg gcttcgagac cttcaccaac     1920

aggttcgacg ccgaggtgtt cgagatcacc accaggtcca tctcctccga gtccaagagg     1980

aaggagaacg cccacgccga gatctggaag gacttctggt ccaaggagaa cgaggagaag     2040

aaccacatca ccaggctgaa cccggaggtg tccgtgttct acagggacga gatcgagaag     2100

aagtccaacg ccctgagggg caacaacaag tccaacatca acaacaggtt ctccgcctcc     2160

aggttcaccc tggtgaccac catcaccatc agggccaccc acaagaagtc caacctggcc     2220

ttcaagaccg aggaggacat caagtcccac atcgacaagt tcaacgaggc cttccagaac     2280

ttctccggcg agtgggtgta cggcatcgac aggggcctga aggagctggc caccctgaac     2340

gtggtgaagt tctccgacga gaagaacgag ttcggcgtga tcaagccgaa ggagttcgcc     2400

aagatcccgg tgtacaagct gaaggacgag aaggccatcc tgaaggacga gaacggcaag     2460

gacctgaaga acgccaaggg cgaggccagg aaggtgatcg acaacatctc cgaggtgctg     2520

gaggagaaga aggagccgga ctccaacctg ttcgagaagc agggcgtgct gtcccagggc     2580

atctcctgca tcgacctgac ccaggccaag ctgatcaagg gccacatcat cctgaacggc     2640

gaccagaaga cctacctgaa gctgaaggag atctccgcca agaggaggat cttcgagctg     2700

ttctccacct ccaagatcga caagaactcc gagctgaggg tggagaagac caccatctcc     2760

atcaactccg aggacggcaa gagggacttc tactggctga ccaagaacca gatcgtgaac     2820

tccgagacca agaaggagat ccagaaggag cagcaggaga agctggacaa cctgaaggtg     2880

atcttcatcg actacctgga gggcctgtgc gtgaagaaca agttcgagga catcgagacc     2940

atcgagaaga tcaaccacct gagggacgcc atcaccgcca acatggtggg catcctgttc     3000

cacctgcaga aggagttcaa gggcatcatc gccctggaga acctggacac cgtgagggag     3060

cagtccaaca agaagatgat cgacgagcac ttcgagcagt ccaacgagga catctccagg     3120

aggctggagt gggccctgta caggaagttc gccaacatgg gcgaggtgcc gtcccagatc     3180

aaggagtcca tcttcctgag ggacgagttc aaggtgtacc agatgggcct gctgaagttc     3240

gtggaggtgt ccggcacctc ctccaactgc ccgaactgcg acaaggaggt gggcaagacc     3300

aactcccact tcgtgtgcaa gggcgagaac aactgcggct tctcctccaa ggagaacagg     3360

aacctgctgg agcagaacct gaacaactcc gacgaggtgg ccgcctacaa catcgccaag     3420

aggggcctga agctgatcaa ccagaagtgg aacaacacct ccaagtccca gaactga        3477


<210>  30
<211>  3195
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.6

<400>  30
atggagaagt acaagatcac caagaccatc aggttcaagc tgctgccgga caagatccag       60

gacatctcca ggcaggtggc cgtgctgcag aactccacca acgccgagaa gaagaacaac      120

ctgctgaggc tggtgcagag gggccaggag ctgccgaagc tgctgaacga gtacatcagg      180

tactccgaca accacaagct gaagtccaac gtgaccgtgc acttcaggtg gctgaggctg      240

ttcaccaagg acctgttcta caactggaag aaggacaaca ccgagaagaa gatcaagatc      300

tccgacgtgg tgtacctgtc ccacgtgttc gaggccttcc tgaaggagtg ggagtccacc      360

atcgagaggg tgaacgccga ctgcaacaag ccggaggagt ccaagaccag ggacgccgag      420

atcgccctgt ccatcaggaa gctgggcatc aagcaccagc tgccgttcat caagggcttc      480

gtggacaact ccaacgacaa gaactccgag gacaccaagt ccaagctgac cgccctgctg      540

tccgagttcg aggccgtgct gaagatctgc gagcagaact acctgccgtc ccagtcctcc      600

ggcatcgcca tcgccaaggc ctccttcaac tactacacca tcaacaagaa gcagaaggac      660

ttcgaggccg agatcgtggc cctgaagaag cagctgcacg ccaggtacgg caacaagaag      720

tacgaccagc tgctgaggga gctgaacctg atcccgctga aggagctgcc gctgaaggag      780

ctgccgctga tcgagttcta ctccgagatc aagaagagga agtccaccaa gaagtccgag      840

ttcctggagg ccgtgtccaa cggcctggtg ttcgacgacc tgaagtccaa gttcccgctg      900

ttccagaccg agtccaacaa gtacgacgag tacctgaagc tgtccaacaa gatcacccag      960

aagtccaccg ccaagtccct gctgtccaag gactccccgg aggcccagaa gctgcagacc     1020

gagatcacca agctgaagaa gaacaggggc gagtacttca agaaggcctt cggcaagtac     1080

gtgcagctgt gcgagctgta caaggagatc gccggcaaga ggggcaagct gaagggccag     1140

atcaagggca tcgagaacga gaggatcgac tcccagaggc tgcagtactg ggccctggtg     1200

ctggaggaca acctgaagca ctccctgatc ctgatcccga aggagaagac caacgagctg     1260

tacaggaagg tgtggggcgc caaggacgac ggcgcctcct cctcctcctc ctccaccctg     1320

tactacttcg agtccatgac ctacagggcc ctgaggaagc tgtgcttcgg catcaacggc     1380

aacaccttcc tgccggagat ccagaaggag ctgccgcagt acaaccagaa ggagttcggc     1440

gagttctgct tccacaagtc caacgacgac aaggagatcg acgagccgaa gctgatctcc     1500

ttctaccagt ccgtgctgaa gaccgacttc gtgaagaaca ccctggccct gccgcagtcc     1560

gtgttcaacg aggtggccat ccagtccttc gagaccaggc aggacttcca gatcgccctg     1620

gagaagtgct gctacgccaa gaagcagatc atctccgagt ccctgaagaa ggagatcctg     1680

gagaactaca acacccagat cttcaagatc acctccctgg acctgcagag gtccgagcag     1740

aagaacctga agggccacac caggatctgg aacaggttct ggaccaagca gaacgaggag     1800

atcaactaca acctgaggct gaacccggag atcgccatcg tgtggaggaa ggccaagaag     1860

accaggatcg agaagtacgg cgagaggtcc gtgctgtacg agccggagaa gaggaacagg     1920

tacctgcacg agcagtacac cctgtgcacc accgtgaccg acaacgccct gaacaacgag     1980

atcaccttcg ccttcgagga caccaagaag aagggcaccg agatcgtgaa gtacaacgag     2040

aagatcaacc agaccctgaa gaaggagttc aacaagaacc agctgtggtt ctacggcatc     2100

gacgccggcg agatcgagct ggccaccctg gccctgatga acaaggacaa ggagccgcag     2160

ctgttcaccg tgtacgagct gaagaagctg gacttcttca agcacggcta catctacaac     2220

aaggagaggg agctggtgat cagggagaag ccgtacaagg ccatccagaa cctgtcctac     2280

ttcctgaacg aggagctgta cgagaagacc ttcagggacg gcaagttcaa cgagacctac     2340

aacgagctgt tcaaggagaa gcacgtgtcc gccatcgacc tgaccaccgc caaggtgatc     2400

aacggcaaga tcatcctgaa cggcgacatg atcaccttcc tgaacctgag gatcctgcac     2460

gcccagagga agatctacga ggagctgatc gagaacccgc acgccgagct gaaggagaag     2520

gactacaagc tgtacttcga gatcgagggc aaggacaagg acatctacat ctccaggctg     2580

gacttcgagt acatcaagcc gtaccaggag atctccaact acctgttcgc ctacttcgcc     2640

tcccagcaga tcaacgaggc cagggaggag gagcagatca accagaccaa gagggccctg     2700

gccggcaaca tgatcggcgt gatctactac ctgtaccaga agtacagggg catcatctcc     2760

atcgaggacc tgaagcagac caaggtggag tccgacagga acaagttcga gggcaacatc     2820

gagaggccgc tggagtgggc cctgtacagg aagttccagc aggagggcta cgtgccgccg     2880

atctccgagc tgatcaagct gagggagctg gagaagttcc cgctgaagga cgtgaagcag     2940

ccgaagtacg agaacatcca gcagttcggc atcatcaagt tcgtgtcccc ggaggagacc     3000

tccaccacct gcccgaagtg cctgaggagg ttcaaggact acgacaagaa caagcaggag     3060

ggcttctgca agtgccagtg cggcttcgac accaggaacg acctgaaggg cttcgagggc     3120

ctgaacgacc cggacaaggt ggccgccttc aacatcgcca agaggggctt cgaggacctg     3180

cagaagtaca agtga                                                      3195


<210>  31
<211>  3321
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.7

<400>  31
atgctgatcc agttcaagaa ccactactcc tacaacaagt ccatcaggtt caagctggag       60

cacaagaacg gcaagctgcc gaagctggag tccgacaacg tggacctgaa caagctggtg      120

gacatcggca actccctgaa ggacatcttc gaggagctgg tgtacaccaa gaacaactac      180

aacaagctga actccctggt gtccatcaag aagcagtggc tgaagatcta cttcaagaac      240

gagttctact ccaacggcaa gatccagaac tactccctgt ccaacttctc ctacctgccg      300

aacaagctga tcgagtggct gaacaactgg cagaacaacc tgaaggccct gatcgagctg      360

accaagcagc aggacttcaa caagaccaag aagtccgaga tcgcctacat cctgtccctg      420

ttcaacggca agtactcctt ctccttcgtg aaggacttct ccacctgcat caaccacaag      480

aactcccagg agcagatcct gaagctgcag ggcgtggtgg agaacttcga gaaggtgctg      540

aacctgtgca tccaggagta cctgccgtcc aagtccgccg gcgtggtgat cgcccagggc      600

tccatgaact actacgccat caacaaggag ccgaagaggt acgacaacat cctggccgac      660

ctgaaccaga agttcgagga gctggacaag gagtacatcg ccatgaagca gtacaagtcc      720

tcccagaagt ccaggctgtt cgagttcatc aggaagggct tctccaagga ccagatcctg      780

tccgagttca agaagaagga gaacaacgag gtgtccttcg tgtacaacaa ccagatcatc      840

atcaggatct acacccagga gctgttcaag gactcctact gcctgggcga ggtgatcaag      900

ctgaccaaga agatcgagga gctgaacgag tccaaggact ccaacaacaa cctgccggag      960

gagaccaaga aggagatcac caagctgaag aaggagatcg gcttctactt catcaggagg     1020

accaggggca agtcccacaa caactacttc aagtcctact acggcttctg caacgacaag     1080

ttcaagaaga aggcccagga gaggggcagg ctgctgacca agatcaaggc catcaggaag     1140

gagaagatcg agtcccagaa cctgaggtac tggtccctga tcctggacga cggcaaggac     1200

aagttcctgt ggctggtgcc gaaggagaac atgcaggagt tcaggaggga gctgtccaag     1260

atccacccgt ccggcgagtc ctccctgttc ctgttccact ccctgaccat gagggccctg     1320

cacaagctgt gcttcgccca ggagtccgac ttcgtgaagg agatgccgaa ggtgctgaag     1380

gaggagcagc tgaactgcga gaaggcctcc aacgacaccg agaccaacaa gaggatcaag     1440

aggaacttcg gcctgaacta catcaagacc aaggacgagc tgaccctgtc cttcctgaag     1500

aagctgatca tctccgagta cgcccacgag aggctggacc tgaaccactt cgacctgtcc     1560

aagctgcagg tggccaccac cctgaacgag ttcgaggagt acctggagga cgcctgctac     1620

tacctggaga agatctccat ctcctcctcc atgatcaagg agctgctgga ggagtacaac     1680

atcctgaact tcaggatcac ctcctacgac ctggagaaga ggaacaagaa cacctaccag     1740

accccggagt ccgacatcaa gaggcacacc aaggagatct ggaacaagtt ctgggagggc     1800

gacaggttca tcaggctgaa cccggagatc aagatcaggt acaggcagaa gaaccagaac     1860

atcgaggact acctgaagga gaagggcttc gacctgacca agatcaagaa caggttcctg     1920

caggagcagt actccgtgtc cttcaccttc gccctgaacg ccggcaagaa gtacccgaag     1980

ctggccttcg tgaagaccga ggagatcctg gagaagatcg aggagttcaa cgacgagttc     2040

aacaagcagt acttcgacaa ctcctacaag tacggcatcg acaggggcaa catcgagctg     2100

gccaccctgt gcatcaccaa gttcaacaag aacgacacct acgagtacaa gggcaagaag     2160

tacctgaagc cgaacttccc gacctcccag gaggacatca agacctacga gctgaagaac     2220

gagtggtaca agaggaccgc catctccaac atcgagacca agccgaagaa caagaagacc     2280

ccgaagagga tcatcgccaa catctcctac ttcatcgaca acgtggagaa cgaggagtgg     2340

ttcaacaaga agacctgcac ctccatcgac ctgaccaccg ccaaggtgat caagggcaag     2400

ctgatcctga acggcgacgt gctgaccttc ctgaagctga agaaggaggc cgccaagagg     2460

atcctgttcg agctggtggc ccagaacaag ctgaccgcca agaacaagga gctgaagtgg     2520

aagtccgacg acggcaacaa ctccgactcc gtgaggctga tctgcgacgt gctggacaac     2580

gagaccaact ccatctactt ctacgaggac tccaagtacg gcaggggctt cgagggcctg     2640

ctgaccaccg acaagaccgc ctactccaag gagggcatca ggatcaacct gcagaactac     2700

ctgaaccacc tgatctccga gaaggagaac aagtccaaca aggcctactc ccacgtgccg     2760

tccatcgaga agatcaacca cctgagggac gccctggtgg ccaacatggt gggcgtgatc     2820

tcctacctgc aggcctacta cccgggcatc gtggtgctgg aggacctgaa ccacaagctg     2880

ctgatcaagc acttcgagga cctgaacatc aacatctcca acaggttcga gcacgccctg     2940

atcgagaagt tccagaccct gggcatggtg ccgccgcaca tcaaggacta cctggagatc     3000

aggtcctcct tcaggatgtc caggaacgac tcctcccagt tcggcgccct gatcttcgtg     3060

tccaaggagg gcacctccaa ggagtgcccg tactgcgaga agaagtggaa ctggggcaag     3120

gagaaggaga tcgagctgaa gttctccaag aagcagtaca tctgcggcaa ggagaactcc     3180

tgcggcttcg acaccaagca catccagaac accttcgagt tcctgtccga gatcaacgac     3240

ccggacaaga tcgccgccta caacatcgcc aagaggggct tcaagtcctt catcaacaag     3300

tcctccatca agaagcagtg a                                               3321


<210>  32
<211>  3258
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.8

<400>  32
atggagaagt acaagatcac caagaccatc aggttcaagc tgctgccgga caagatccag       60

gacatctcca ggcaggtggc cgtgctgcag aactccacca acgccgagaa gaagaacaac      120

ctgctgaggc tgatccagag gggccaggag ctgccgaagc tgctgaacga gtacatcagg      180

tactccgaca accacaagct gaagtccaac gtgaccgtgc acttcaggtg gctgaggctg      240

ttcaccaagg acctgttcta caactggaag aaggacaaca ccgagaagaa gatcaagatc      300

tccgacgtgg actacctgtc cagggtgttc gaggacttct tcaacgagtg ggagaccgtg      360

atcgagagga tcaacaccga ctgcaacagg ccggaggagt ccaagaccag ggacgccgag      420

atcgccttct ccatcaagaa gatcgccacc aagcagatgt tcccgttcat caagtccttc      480

gtgtacaact ccaactacaa gaactccgag gagaccaagt ccaagctgac cgccctgctg      540

aacgagttcg agaccgtgct gaagatctgc gagcagaact acctgccgtc ccagtccgcc      600

ggcatcgtga tcgccaaggc ctccttcaac tactacacca tcaacaagaa gcagaaggac      660

tacaagggct acaccgacga catcgagaag atcgagaagg gcatgaactc caagttccac      720

tacgagagga agtacgacca gctgctggag gagctgaacc tgatcgccct gaaggagctg      780

ccgctgatcg agttctactc caagatcaag tcctacaagt ccaccaggaa gatcgagttc      840

tccgaggccg tgtccaaggg cctggccttc gccgacctga agtccaagtt cccgctgttc      900

cagaccgagt ccaacaagta cgccgagttc ctggagctga ccggcaggat cacccagatc      960

tccaccgcca agtccctgct gtccaaggac aacccggagg cccagaagct gagggacgag     1020

atcaagaagc tgaggatcaa caggggcgag tacttcaaga acaacttcca caagtacatc     1080

tccctgtgca acctgtacaa gaagatcgcc gacaagaagg gcaggctgaa gggccaggtg     1140

aagggcatcg agaacgagag gatcgactcc cagaggatcc agcactgggc cctggtgctg     1200

gaggacaacc tgaagcactc cctgatcctg atcccgaagg agaaggtgac cgaggtgtac     1260

aggaaggtga gggcctccaa ggccgactcc acctcctcct cctcctccct gtactacttc     1320

gagtccatga cctacagggc cctgcacaag ctgtgcttcg gcgtgaacgg caacaccttc     1380

ctgccggaga tccagaagga gctgccggag tacaacccga acaagcagtc cgacttcggc     1440

gagttctgct tccacaagtc caacaccgac aaggagatcg acgagccgaa gctgatctcc     1500

ttctaccagt ccgtgctgaa gaccaactac gtgaaggaca acctgaacct gccgcagtcc     1560

gtgttcgacg aggccaccgt gcagaccttc gagaccaggc aggacttcca gatcgccctg     1620

gagaagtgct gctacgccaa gaagaccatc atctccgaga ccctgaagaa ggagatcctg     1680

gaggacaaca acgtgcagat cttccagatc acctccctgg acctgcagag gtccgagcag     1740

aagaacctga aggcccacac caagatctgg aacaggttct ggaccaagca gaacgagacc     1800

gccaactacg acctgaggct gaacccggag accgccatcg tgtggaggaa gccgaagaag     1860

accaggatcg acaagtacgg cgccggcacc tccctgtacg acccgaagaa gaggaacagg     1920

tacctgcacg agcagtacac cctgtgcacc accgtgaccg acaacgccct gaacaacgag     1980

atcaccttcg ccttcgagga caccaagaag aagggcaccg agatcgtgaa gtacaacgag     2040

aagatcaacc agaccctgaa gaaggagttc aacaagaacc agctgtggtt ctacggcatc     2100

gacgccggcg agatcgagct ggccaccctg gccctgatga acaaggacaa ggagccgcag     2160

ctgttcaccg tgtacgagct gaagaagtcc gacttcttca agcacggcta catctacaac     2220

aaggagaggg agctggtgat cagggagaag ccgtacaagg ccatccagaa cctgtcctac     2280

ttcctgaacg aggagctgta cgagaagacc ttcagggacg gcaagttcca ggagaccttc     2340

aacgagctgt tcaaggagaa gcacgtgtcc gccatcgacc tgaccaccgc caaggtgatc     2400

aacggcaaga tcatcctgaa cggcgacatg atcaccttcc tgaacctgag gatcctgcac     2460

gccaagagga agatctacga ggagctgatc atcaacccgc aggccgagct gaaggagaac     2520

gagaaggagt actacctgta cttcgacaag gagggcaccg agaaggtgga gaagatctac     2580

aggtccaggc tggacttcga gcacatcaag ccgtaccagg agatcaggaa cgacctgaac     2640

gcctacttca agaacgtgca gaagaacgag gccaaggtgg aggaccagat caaccagacc     2700

aggagggccc tggtgggcaa catgatcggc gtgatctact acctgtacca gaagtacagg     2760

ggcatcatct ccatcgagga cctgaagcag accaaggtgg agtccgacag gaacaagttc     2820

gagggcaaca tcgagaggcc gctggagtgg gccctgtaca ggaagttcca gcaggagggc     2880

tacgtgccgc cgatctccga gctgatcaag ctgagggagc tggagaagtt cccgctgaag     2940

gacgtgaagc agccgaagta cgagaacatc cagcagttcg gcatcatcaa gttcgtgtcc     3000

ccggaggaga cctccaccac ctgcccgtcc tgcgagaaga aggcctacga gctgcagaag     3060

gagaagaagg gcgaggagaa gccggccgag aacaagaggt acgaggccga caagaaggcc     3120

ggcgtgttct gctgcccgaa gtgcggcttc cacaacagga ccaacccgat gggctacgag     3180

tccctggact ccaacgacaa ggtggccgcc ttcaacatcg ccaagagggg cttcgaggac     3240

ctgcagaagc acaagtga                                                   3258


<210>  33
<211>  3102
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.9

<400>  33
atggagaact ccaacctgta ccaggtggtg aagaccatca ggttcaagct ggagccggtg       60

ggcaagatgg acaccccgaa gttcggcgac aagaacgccg agtccaaggc caacctgacc      120

ccgttcatcg agctggtgaa gaagaccatg accaacgtga aggccctggt gttctccaag      180

caggacggcg aggacggcga gaagtggagg aagatcctgg aggtgaacta caggttcctg      240

aggtcctacc tgaagaactc cttctacgag aacaggggcg actcccagga gaagtccaag      300

aagcacaaga tctccgacct ggagtacctg cagaaggccc tggagaacct gttcgccgag      360

ttcgacgaga tcctggacgg cctggaggac ttcgagaaga ggaacaccaa gaaccagtac      420

gagaagcaga ggcacgccca ggccggcctg ctgctgaaca ggctgtgcaa gaggtccaac      480

ttcggcttcc tgaaggcctt cgtgggcgcc ctggcccaga ccaacaagcc gttcttcgac      540

gacaagaccg acaagctgaa gaagcagatc gacaagttcg agaccgagct ggagaagcag      600

aaggagttct tcctgccgta ccagtccaac ggcgtgctgt tcgccggcgg ctccttcaac      660

aggtacgcca tcaacaagac cccgaagatg ctggacaagg agctgaggga ggagcagacc      720

aacctgaaga agtccctgtg cgagcacaag atcaagatcg acaccctgaa caccctgggc      780

ctgaagaacg actgcccgtg cacctccctg gacaactcct acaccttcat caaggactac      840

aaggccaagc agaagtccaa gttcatcgag ctggtgcaga agggcgagtt cgacgaggcc      900

aagaaggtga acctgttcga gtgctccgag accgacttcg agaccttcaa gaccaggacc      960

aagcagatcc agaacgagaa ggacaaggac gagaggacca agctgaagca gaagaggggc     1020

gagttcttca agtcccagaa gaggggcaag ttcttcaagt cccagaccca gaactacgag     1080

aacctgtgcg acctgtacaa gaagatcgcc cagaagaggg gccagatcgt ggccaagatc     1140

tgcgccatca agaaggagaa ggagatgtgc gagcaggtga agtactggtg cgtggccctg     1200

gagaagggcg gcgagttcta cctgtacatg ttcctgaggg acgagaacga caacatcaag     1260

aacgcctacg acttcgtgtc caagctgcag acccagaagt ccggcgagac caagctgcac     1320

tacttcgact ccctgaccct gaaggccgtg aggaagctgt gcttcaagga gaccgacggc     1380

tccttcaaga aggccctgaa gaacgtgaag ttcccggagt gcgagcagaa cctggacgag     1440

aaggtgaaga tctccttcta ccagaacgtg ctgaagaacg ccaagaccct gaacctgtcc     1500

aagttcgaga acctgcagtc cgtgaccgag ggcaagttcg agtccctgtc cgagttcgag     1560

gtggccctga acatggtgtg ctacaccaag accgtgtgcg tgtccgagtc cgtggagaag     1620

gagctgaaga agttcaagcc gctggtgttc cacatcacct cccaggacct ggccgccaag     1680

agggagaaga aggcccacac ccagatctgg cacgagttct ggagggagtc caacgagaag     1740

tccaagttcc cgctgaggct gaacccggag ctgaaggtga tgtggaggga ggccaggccg     1800

tccagggtgg agaagtacgc cgagcagtcc gacaagttcg acccgaacaa gaagaacagg     1860

tacctgcacc cgcagttcac cctggccctg aacttcaccc agaacgccca caacgaggcc     1920

atcaacctgg ccttcaagga cgtgcagaac aagggcgagg ccgtgaagaa gttcaacgag     1980

aacttcaagt cctccgagta cgccttcggc atcgacgtgg gcaccaagga cctggccctg     2040

ctgtgcctga tcgacaagaa caagaagccg gtgaacttcg acgtgtacga gatctgcaac     2100

gagaacgaga tctgcaacga gaagctgggc ttcgagaagt tcggcttcta caaggacggc     2160

accaggaggg acgagccgta caagctgatc aagaacccgt cctacttcct gaacgagtcc     2220

ctgtacaaga agaccttcaa cgccaccaag gaggagttcg agaggtcctt ctccgagctg     2280

ttcaagagga agtccgtgtg cgccctggac ctgaccaccg ccaaggtgat ctgcggcaag     2340

atcatcctga acggcgactt ctccacccac ctgaacctga agatcctgaa cgccaagagg     2400

aagatctccg ccaagctgaa gaaggacccg accctgaaga tcgagtacga caacgacgac     2460

aacatcctgt tcggctccaa cgtgatcttc tactacaaca acaagtacga gatcgtgagg     2520

ccgtacgacg agatcaagaa cgagatcttc gagttccacg agaagcagag gctggacgac     2580

gccaggctgg aggacaacat caacaagacc agggccaacc tggtggccaa catggtgggc     2640

gtgatctcct tcctgcacaa ggagttctcc ggcttcgtgg tgctggagaa cctgaagcag     2700

tccgagatcg agggcaacca caggctgaag ttcgagggcg acatcaccag gccgctggag     2760

ctggccctgt acaggaagtt ccagtccaag tgcctgaccc cgccgatctc cgagctgatc     2820

aagctgaggg agggcgagaa gaacgagaac gtggagtccg acctgatcct gcagttcggc     2880

atcatcaagt tcgtggacaa ggacaagacc tccaggctgt gcccggcctg cggcaaggac     2940

gcctacgaga acaacaactc caagtacaag accgacaaga aggacggcgt gttcgagtgc     3000

gccggctgcg gcttcaacaa caagaacaac gccggcgact tcgccgccct ggacaccaac     3060

gacaagatcg ccaccttcaa catcgccaag aggggcctgt ga                        3102


<210>  34
<211>  3507
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.10

<400>  34
atggagacct acaagatcac caagaccatc aggttcaagc tggaggccga cgaggagaac       60

tccatccaca tcaaggagga catcatcaac atcgagacca acgacaacga gttcaccatg      120

gtggacttcg tgtccaacct gggcaactac atcaaggacc tgaagaacta cctgttctac      180

gagaagaagg acggctccct gtccttcaag gacaagatca tcatcaagaa cgagtggctg      240

aggcagtacg ccaagcagga cttcgtggag ctgaagtcca agaagaggat caacctgagg      300

aacaacagga tggagcagat caagatcggc gacatcccga ggctgtcctc caagatcgag      360

gaggccctgg acatcgccaa ggagatctac tccaagctgt ccgacgacgc caccctggag      420

cagcacgaga ggaccaagaa ggcccagatc ggcctgctgc tgaagaggct ggaggccaag      480

aacgtgctgc cgctgctgat ggacctggtg aaggagaccc tggacaagga cgagaccgac      540

gacctgtcca tcaggctgaa gaggcagtcc cagaagatca actcccagct gaagatcgcc      600

atcaggtcct tcctgccgga gcagtccaac ggcctgcaga tcgccaaggc ctccttcaac      660

tactacacca tcaacaagaa gccgatcgac ttcgagaaga agatcgagga cctgaagaag      720

aacctgaacg tgaaggacct ggagaagctg aacgtgtact tcgacaagaa ggagaagaag      780

cagaagaact acctgggcaa gaagatcttc tccctgttcg agaccgacat ccagaaggcc      840

ctgtccaaga accagccgct gtacctgggc gacgccccga tgatcgactc cgcctacgtg      900

tccctgaggc agatcttcaa gaagatcaag tccgagcaga agaagcagtt ctccgagctg      960

atgcagaaca agtgctccta cgacgagctg aagaactcca acctgtacct gctgaacgac     1020

atcggcctgg agcagttcaa cacctacagg gagaagacca aggagctgga ggagctggcc     1080

accaagctgt ccaaccagaa cctgctggag aacgccaagg agaggctgag gtcccagaag     1140

gagaagatcg ccaaggagag gggcaacatc atgaaggaca ggttccagac ctggaagtcc     1200

ttcgccaact tctacaggac cgtgtcccag aagcacggca agatcctggc ccagctgaag     1260

ggcatcgaga aggagcaggc cgagtcccag ctgctgaagt actgggccct gatctgcgag     1320

aaggagaacc agcaccagct gtggctgatc ccgagggaga aggcctggga gtgcaagagg     1380

tggctggaga ccgtgaacga cacctccatc gacaacgaga actccatcaa gctgtactgg     1440

ttcgagtccc tgacctacag gtccctgcag aagctgtgct tcggcttcct ggagaacggc     1500

aacaacgagt tcaaccagaa catcaaggac ctgctgccga aggacaggat cggcaacacc     1560

atcaacggcg agttcgcctt cgagggcgac gaggagagga agatcgagtt ctacaagacc     1620

gtgctgaact ccaagtacgc caagcaggtg ctgaacatcc cgttcaagca ggtggaggag     1680

gagatcatct cccagtcctt cgagaacctg tccgacttcc agatcgccct ggagaagatc     1740

tgctacagga ggttcgccat ctactccaac tacatcatct ccttcgacgc ccagatcttc     1800

gacatcacct ccctggacct gaagaacaac gagaagaaca acctgaacac ccacacccac     1860

atctggaggg acttctggaa ggacgagaac gagaagaaca acttcgacat caggctgaac     1920

ccggagatca ccatctccta caggaccccg aagcagtcca ggatcgagaa gtacggcgag     1980

aagaccaagg agtacgaccc gaacaagaac aacaggtacc tgcacccgca gttcaccctg     2040

atcaccacca tctccgagag gtccaactcc cagaccaaga ccctgtcctt catcgaggac     2100

gaggacttca agaagtccat caacgagttc aacaagaagc tgaagaagga caacatcaag     2160

ttcgccttcg gcatcgacaa cggcgaggtg gagctgtcca ccctgggcgt gtacctgccg     2220

accttcgaga aggagaccca cgaggagaag atctacgagc tgaagcagat caagaagtac     2280

ggcttcgagg tgctgaccat caccgacctg aagtacaagg agaccgacta caacggcaac     2340

gtgaggaaga tcatccagaa cccgtcctac ttcctgaaga aggagaacta catcaggacc     2400

ttctccaagt ccgagcagga gtacgaggag atgttcgcca agctgttcaa gaaggagcac     2460

gtgctgtccc tggacctgac caccgccaag atgatctgcg gccacatcgt gaccaacggc     2520

gacgtgccgg ccctgttcaa cctgtggctg aagcacgccc agaggaacgt gttcgagatg     2580

aacgaccaca ccgtgaagga gaccgccaag accatcaggc tgaggaacaa cgaggagctg     2640

accgacaacg agaaggagaa gttcgccgag ttcatctccg acggcaagaa gttcgccaag     2700

ctgaccaagg agggcaagaa gtccaggtac ctgaagtgga tcttcgagga caggaaggag     2760

aactccttca ccgaggacga gaacaagaag ttcaacgact gccagaagaa gaagggcaag     2820

tacaactccc acatcatctt cgcctccagg ttcgagggcg acgagctgaa gtccgtgacc     2880

ccgatcttcg actgcaggca cgtgttcaag aagaggaagg agttcgagac catcaggccg     2940

atcaaggaga tcgagaacga gatctccagg ttcaacacca acaggacctc ccacaacatc     3000

tccaacgagg agctggacct gaagatcacc gacgccaaga aggccctggt ggccaacgcc     3060

atcggcgtga tcgacttcct gtacaagcag tacaagcaga ggttcaacga cgagggcctg     3120

atcatcaagg agggcttcga cacccagaag gtggaggagg acatcgagaa gttctccggc     3180

aacatctaca ggatcctgga gaggaagctg taccagaagt tccagaacta cggcctggtg     3240

ccgccgatca agaacctgat ggccgtgagg aacgagggca tcaaggacaa gaacgccatc     3300

ctgaggctgg gcaacatcgc cttcatcgac ccgtccggca cctcccagga gtgcccggtg     3360

tgcaaggaga agtccaagga gaagcacacc aacaacttca tctgcgagtg cggcttcaac     3420

tccaccaaca tcatgcactc caacgacggc atcgccggct tcaacatcgc caagaggggc     3480

ttcgagaact tcatcaacga gaagtga                                         3507


<210>  35
<211>  3564
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.11

<400>  35
atggagaagt acaagatcac caagaccatc aggttcaggc tggacgccga caacaccgcc       60

atctccgcca tcgtgaagga caccgaggcc ctggaggcca ggggccaggg cttcaagatc      120

aagaagttcg tgaacgccct gggcaggttc ctgtccggcg acggcgtgca gaagtacctg      180

tacgacatgt ccaacgagga gaactgcgtg ttcaagagga acctggtgat caagaacacc      240

tggctgaaga acaacgccaa gcaggagatc gccggcatgg acctgaagag gggcctgatc      300

atcaaggaca tcaagggcct gcaggacaag atcgaggaga tctacgacaa gctgtgggag      360

atctacgaga tcctgtacga gtccgcctac ctgccgctgc aggacctggc caggagggag      420

ggcatcggcc tgctgctgaa gaagctgtcc gtgaagaacg ccctgccgtt catcatctcc      480

ttcgtggagg agtccaacga caagaacgag gccgacgacc tgtccctgag gctgaagaag      540

cagggcaagg agatcctgac ccagctggag atcggcatca acgagtacct gccggcccag      600

tcctccggcc tgccggtggc caaggcctcc ttcaactact acaccatcaa caagaccccg      660

gtggacttcg gcgagaagat ccaggagctg gagaagaggc tgtccgtgga catcaagaag      720

gagatctcct ccttcaccgg cggcatcaag accgccatca agaacaagat cgccggcaag      780

aagatcctgc tgggcgacac cccgatgttc gagtccgaga actccgtgtc cctgaggcag      840

atcctgaaga acatcaagtc cgagcagaag gcccagttca acaagttcat gaccacccag      900

aacaacccgc agctggagga gatgaagacc atgggctggt acctgttcgg cgacatcacc      960

gagggcgagt tcaacgacta caaggagcag accaaggaga tcgagagggt gggcgccaag     1020

atcaaccagt gcggcaacat caaggagaag aaggagctga ggtcccagct gcagaagctg     1080

aagaagaaga ggggcgagct gatctccgag gcccacaaga agggcggcaa cgacaagaac     1140

ttcaagacct acaaggagtt cgccaagttc tacaggaaga tcgcccagag gcacggcaag     1200

atcctggccc agatcaaggg catcgagaag gagaagatcg actccgccat gctgaactac     1260

tgggccgccg tgatcgagct gtccggcagg cacaagctgg tgctgatccc gaagaaggac     1320

gagaacgcca agaagtgcat cgagtggctg gaggacgagt ccaagcacaa gaacggctcc     1380

tgcaagatct tctggttcga gtccttcacc ttcaggtccc tgcagaagct gtgcttcggc     1440

aacctggact ccggcaccaa caccttcaac cagaagatcc agaacctgct gccgtgcgac     1500

gagaggggca acctgatgaa cggcgagttc gccttcaagg gcgacgagca ggagaagatc     1560

aagttctaca agaaggtgct gcagtcccag aaggacatca acctgccgca gaaggaggtg     1620

gtggacaacg tggtgggcag gaagttcgag accatggacg agttcaagat cgccctggag     1680

gagatctgct acatcaggag ggagaggctg tccgccaacg ccgagtccga gctgaagtcc     1740

aagttcaacg cccagatctt cgacatcacc tccctggacc tgaggaaccc ggtgaactgc     1800

gccggcaagc cggaggtgta ccaccacaac gacaagaggc acaccgagat ctggaaggag     1860

ttctggtccc tggacaacga gaggaggaac ttcaacatca ggctgaaccc ggagatcacc     1920

atcacctaca ggaagccgaa ggagtccagg atcctgaagt acggcaaggg caccgagaag     1980

tacaacgccg acatgaagaa caggtacctg tacccgcagt acaccctgct gaccaccatc     2040

tccgagcact gcaacacccc gaccaagatc ctgtccttca tgaccgacaa cgagtacgag     2100

gagtccatca aggccttcaa ctccaagctg aagaaggagg acatcaagtt cgccttcggc     2160

atcgactccg gcgagaccga gctgtccacc ctgggcgtgt acctgccgga gttctccgcc     2220

gagtccaccg agctgaagga catcgagaag tacggcttca acgtgctgac catcaaggac     2280

ctgaactaca ccgagaccga ctacaacggc tccgacaaga agatcgtgaa gaacccgtcc     2340

tacttcgtgg acaagtccct gtacatgagg accttcaaga agaccgagca ggagtacgag     2400

aagatgttcg ccgagcagtt cgaggccaag aagaggctgt ccctggacct gtccgccgcc     2460

aaggtgatct gcggccacat cgtgaccaac ggcggcgtgt ccgagcactt cggcctgtgg     2520

ctgaagcacg cccagaggac catcttctgg atgaacgacc acaccgagaa gaagaccgcc     2580

aagaacatca agctgaagga ctcctccgag ctgacctacg acgagaggga gaagttcgcc     2640

gagcacatct cctccgacga gaagttcaag aagctggacg tggaggagaa gaagaggtac     2700

gtgaggtgga tcttcgagga cagggagacc ctgaacttca ccgaggccga gaacaagaag     2760

ttcggcggct accagaagaa gaagggcgac tacaggctgg gcatcctgtt cgcctcctgc     2820

ttcatcggca aggagctgga gtccgtgacc cagatcctgg actgcaggca catcttcaag     2880

aagagggagg agttctactc cctgaagtcc aaggaggaca tcgaggccga gatcaagagg     2940

tacaacaccg actacaccaa ccacaacatc tccaccgagc agctggacct gaagttcgtg     3000

aacgtgaaga acgccctggt ggccaacgcc gtgggcgtga tcgacctgct gtacaagcag     3060

tacaaggaga ggctgggcgg cgagggcctg atcgccaagg agggcttcga caccaagaag     3120

gtggaggagg acatggagaa gttctccggc aacatctaca ggatcctgga gaggaagctg     3180

taccagaagt tccagaacta cggcctggtg ccgccgatca agaacctgat ggccgtgagg     3240

gccgacaagg tggagatctc cgaggccgag aagtccaaga tcagggagaa ctgcaagatc     3300

tccaagatcg acccggagaa cgagatcatc aagaggaaca agaccctgat cctgaggctg     3360

ggctccatcg ccttcgtgaa cgacgccgac acctcccagg agtgcccggc ctgcggcacc     3420

aagtccaagg agaagcacgt ggacaacttc atctgcggct gcggcttcaa ctccaccggc     3480

atcatccact ccaacgacgg cgtggccggc ttcaacatcg ccaagagggg cttcgtgaac     3540

ctgatggagc acgagctgag gtga                                            3564


<210>  36
<211>  3588
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.12

<400>  36
atggagaagt acaagctgac caagaccatc aggttcaagc tgaagccgaa ggacatctcc       60

gccatcaaga gggacgtgga ggccctggag cagcagaagt tcgacctggt gctgttcgtg      120

tacaacctgc acaacttcat cggcaagctg aaggagtacc tgttcttcca gaaggagaag      180

gacgagttcg tgatcaagga caagctgacc atcaagaaga cctggctgaa gcagtacgcc      240

aagcaggaga tcgccggcct ggagctgaac agggagcaga ccctgggcaa catcaagggc      300

gtgtccgcca ggatcgagag ggccgtggac gacgtgaaca agatctacgt ggagctggcc      360

atggaggcca agctgaacga gagggccaag aaggccaaga ccgagcagct gatcaagagg      420

ctggacacca ggaacgccct gccgctgctg gtgtccctga tcgagcagtc ctccgacaag      480

tacgagaccg gcaacctgtc catccagctg aagaggctgg gcaagaggct gcagacccag      540

ctgctgtccg gcatcaagaa gtacctggcc gagcagtcca acggcctgcc gatcgccaag      600

gcctccttca actactacgc catcaacaag aagccggtgg actacatcga caagatcaag      660

cagctgcaga aggacctgga gatcaagaag aacaggaggt ccgaggagag gtacgacaag      720

aagaagagga agaacatcaa gatcttcaac gactccaagc tgtggatcaa gatcaagaag      780

gacatcgaga aggagagggg caacaagacc ctgatcctgg gctacgcccc gatgatcgag      840

ccgggcaact acgtgtacct gaggcagatc ctgaagaaca tcaagctgga gcagaagaac      900

aagttctcca agctgatgca gtccaagtcc ctgaccttcc acgacctgaa caacaacaac      960

cagctgtacc tgttcaagga catcctggag ggcgagttca acaagtacaa gcagaagacc     1020

aacgagatcg agaccaaggc cgagaagagg aaccagtgca acaacgacga gctgaagagg     1080

aagctgaact ccgagctgca gcagctgagg aaggacaggg gctccctgat caacgccgcc     1140

gacggcaggc cgaagggcag gttcaagacc tacaagtact tcgccaactt ctacaggaac     1200

gtggcccaga agcacggcag gatcctgtcc accctgaagg gcatcgagaa ggagatggtg     1260

gagtcccagc tgctgaagta ctggaccatc atcaccgagg agaacaacca gcactccctg     1320

gtgctgatcc cgaaggagag ggccggcgag tacaagaagg acctggagaa ctccatcccg     1380

tccgacccgt cctccaagat caaggtgtac tggttcgagt ccttcaccct gaggtccctg     1440

aggaagctgt gcttcggcta cgtgaacaac aacaccggct ccaacacctt ctacccggag     1500

ctgaagaagt ccgacgagct gaggaagtac cacgacgaga ggggcaactt catcaagggc     1560

gagttctact tcaagggcga cgagcagaag atcatccagt tctacaagga cgtgctgagg     1620

tccaactacg cccagaaggt gctgaagttc ccgaagcagc aggtgaagga cgagctgatc     1680

ggcagggagt tctcctccct ggacgagttc cagatcgccc tggagaagat ctgctaccag     1740

aggcacgtgg tgtgctccca gaaggtggtg gacgccctgt ccaggtacaa cgcccagatc     1800

ttcctgatca cctccctgga cctgggcaac ccggccaact gcgtggacaa gccgaagcag     1860

ttctcccact tcgacaagaa gcacaccagg atctggaagg agttctggtc ctccaagaac     1920

gagaccgcca acttcgacat caggctgaac ccggagatcg tgatcaccta caggcagccg     1980

aagcagtcca ggatcaagaa gtacggcccg gagtccacca ggtacgacga caggaagcac     2040

aacaggtacc tgtacccgca gttcaccctg atcaccacca tctccgagta ctccaacgcc     2100

ccgaccaagg ccctgtcctt cctgaccgac gaggagttca agggcgccgt ggacgagttc     2160

aacaagaagt tcaagaagga gaacatcagg ttctccctgg gcatcgacaa cggcgagacc     2220

gagctgtcca ccctgggcgt gtacctgccg gtgttcaaga aggactccaa cgagaaggtg     2280

gtggccgagc tgaagaaggt gaacaagtac ggcttcaact tcctgaccat caaggacctg     2340

tcccacgtgg agaaggacaa gaacggcagg gtgaggaaga tcatccagaa cccgtcctac     2400

ttcctgtcca aggagcagta catgaggacc ttcggcagga ccgagcagga gtacaacaac     2460

atgttcgccg agcagttcga ggagaaggcc ttcctgtccc tggacctgac caccgccaag     2520

gtgatcaacg gccacatcgt gaccaacggc gacgtgccga ccttcctgaa cctgtggatg     2580

aggcacgccc agagggacat ctgggacatg aacgaccaca ccaaggagaa gaccgccaag     2640

aagatcgtga tcaagaacaa cgacgagctg accgacgccg agaaggtgaa gttcgtggag     2700

tacatctccg acgagaccaa ctacgccaag ctgaacttca acgagaagaa gaggtacgtg     2760

ctgtggatct tcgagaacag gaagaacatc aacttcaccg acgccgagaa gaagaagttc     2820

gagccgtgcc agaagaggaa gggcaacttc tccaaggaca tcctgttcgc cgtgtgctac     2880

atcggctccg agatccactc cgtgaccaac atcttcgacg tgaggaacat cttcaagatg     2940

aggaaggact tctacgtgct gaagtccgag atggagatca agaaggagat cgagtcctac     3000

aacaccaccg ccggcatcca ggagatctcc aacgaggagc tggacctgaa gatcaacagg     3060

ctgaagcagg ccgtggtggc caacgccgtg ggcgtgatcg actacctgta catctactac     3120

aagaagaaga ccggcggcga gggcctgatc atcaaggagg gcttcgacac caagaaggtg     3180

gccaaggccc tggagaagtt ctccggcaac atctacagga tcctggagag gaagctgtac     3240

cagaagttcc agaactacgg cctggtgccg ccgatcaagt ccctgatggc cgtgagggag     3300

gagggcatcg agaacaacaa ggacgccatc ctgaggctgg gcaacgtggg cttcatcgac     3360

ccgaccggca cctcccagca gtgcccggtg tgctccaagg gcaagctgaa ccacaccacc     3420

aagtgctcca agaactgcgg cttcaactcc aagaacatca tgcactccaa cgacggcatc     3480

gccggctaca acatcgccaa gaggggcttc gagaacttca tctcccagaa gaagggctac     3540

gacgtgatca acaacggcac caagtacaac aacctgaagt cccagtga                  3588


<210>  37
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12g.1ԭͬظ

<400>  37
gucuaauaug auaguaaaau auuauauagu uuagac                                 36


<210>  38
<211>  37
<212>  RNA
<213>  ˹

<220>
<223>  Cas12g.2ԭͬظ

<400>  38
uguguuggua ucuaguaaaa ucuagagccg uugacac                                37


<210>  39
<211>  40
<212>  RNA
<213>  ˹

<220>
<223>  Cas12h.1ԭͬظ

<400>  39
augugcugca uggcaacgcu agaugccaug uguucgcaac                             40


<210>  40
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12h.2ԭͬظ

<400>  40
gugcugaugc uauucaauag gauagaauca aggcac                                 36


<210>  41
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12w.1ԭͬظ

<400>  41
gucuaaaccg acccaauaau uucuacuguu guagau                                 36


<210>  42
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12w.2ԭͬظ

<400>  42
gccuacaaag gcacacaaau uucuacuauu guagau                                 36


<210>  43
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.1ԭͬظ

<400>  43
cucuaauacc uauacacaau uucuacuuuu guagau                                 36


<210>  44
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.2ԭͬظ

<400>  44
aucgaacaga cucauaaaau uucuacuguu guagau                                 36


<210>  45
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.3ԭͬظ

<400>  45
ggcuaauauc ccuaucagau uucuacuuuu guagau                                 36


<210>  46
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.4ԭͬظ

<400>  46
cucuacaacu gauaaagaau uucuacuuuu guagau                                 36


<210>  47
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.5ԭͬظ

<400>  47
guuuaauucg uauauuuaau uucuacuuuu guagau                                 36


<210>  48
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.6ԭͬظ

<400>  48
guccaaagga cggauuaaau uucuacuauu guagau                                 36


<210>  49
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.7ԭͬظ

<400>  49
gucuagaagc augcucuaau uucuacuguu guagau                                 36


<210>  50
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.8ԭͬظ

<400>  50
guccaaagga cggauuaaau uucuacuacu guagau                                 36


<210>  51
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.9ԭͬظ

<400>  51
gucuagacca caaauuuaau uucuacuauu guagau                                 36


<210>  52
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.10ԭͬظ

<400>  52
guuuaggagu uaaauagaau uucuacuauu guagau                                 36


<210>  53
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.11ԭͬظ

<400>  53
gucuauaggc ggguuuuaau uucuacuauu guagau                                 36


<210>  54
<211>  36
<212>  RNA
<213>  ˹

<220>
<223>  Cas12j.12ԭͬظ

<400>  54
gucuaauagu uaaucaaaau uucuacuauu guagau                                 36


<210>  55
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12g.1ԭͬظеı

<400>  55
gtctaatatg atagtaaaat attatatagt ttagac                                 36


<210>  56
<211>  37
<212>  DNA
<213>  ˹

<220>
<223>  Cas12g.2ԭͬظеı

<400>  56
tgtgttggta tctagtaaaa tctagagccg ttgacac                                37


<210>  57
<211>  40
<212>  DNA
<213>  ˹

<220>
<223>  Cas12h.1ԭͬظеı

<400>  57
atgtgctgca tggcaacgct agatgccatg tgttcgcaac                             40


<210>  58
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12h.2ԭͬظеı

<400>  58
gtgctgatgc tattcaatag gatagaatca aggcac                                 36


<210>  59
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12w.1ԭͬظеı

<400>  59
gtctaaaccg acccaataat ttctactgtt gtagat                                 36


<210>  60
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12w.2ԭͬظеı

<400>  60
gcctacaaag gcacacaaat ttctactatt gtagat                                 36


<210>  61
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.1ԭͬظеı

<400>  61
ctctaatacc tatacacaat ttctactttt gtagat                                 36


<210>  62
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.2ԭͬظеı

<400>  62
atcgaacaga ctcataaaat ttctactgtt gtagat                                 36


<210>  63
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.3ԭͬظеı

<400>  63
ggctaatatc cctatcagat ttctactttt gtagat                                 36


<210>  64
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.4ԭͬظеı

<400>  64
ctctacaact gataaagaat ttctactttt gtagat                                 36


<210>  65
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.5ԭͬظеı

<400>  65
gtttaattcg tatatttaat ttctactttt gtagat                                 36


<210>  66
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.6ԭͬظеı

<400>  66
gtccaaagga cggattaaat ttctactatt gtagat                                 36


<210>  67
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.7ԭͬظеı

<400>  67
gtctagaagc atgctctaat ttctactgtt gtagat                                 36


<210>  68
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.8ԭͬظеı

<400>  68
gtccaaagga cggattaaat ttctactact gtagat                                 36


<210>  69
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.9ԭͬظеı

<400>  69
gtctagacca caaatttaat ttctactatt gtagat                                 36


<210>  70
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.10ԭͬظеı

<400>  70
gtttaggagt taaatagaat ttctactatt gtagat                                 36


<210>  71
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.11ԭͬظеı

<400>  71
gtctataggc gggttttaat ttctactatt gtagat                                 36


<210>  72
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  Cas12j.12ԭͬظеı

<400>  72
gtctaatagt taatcaaaat ttctactatt gtagat                                 36


<210>  73
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  NLS

<400>  73

Ser Arg Ala Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10      


<210>  74
<211>  893
<212>  PRT
<213>  ˹

<220>
<223>  Cas12g.1-NLSںϵ׵İ

<400>  74

Met Leu Tyr Thr Met Asn Val Lys Thr Ile Lys Leu Lys Val Asp Ala 
1               5                   10                  15      


Thr Lys Glu Val Glu Ser Arg Leu Thr Lys Met Leu Leu Val His Asn 
            20                  25                  30          


Asn Ile Gly Arg Glu Ile Ile Asn Phe Leu Ile Leu Cys Ser Gly Asn 
        35                  40                  45              


Asp Asn Ile Arg Lys Thr Lys Phe Asp Glu Phe Gly Asn Ser Tyr Asp 
    50                  55                  60                  


Glu Phe Cys Asn Leu Lys Leu Asp Gln Phe Asn Leu Tyr Asp Arg Leu 
65                  70                  75                  80  


Thr Glu Ile His Asp Glu Val Thr Leu Glu Asp Phe Gln Lys Thr Leu 
                85                  90                  95      


Asn Asp Ile Tyr Asp Leu Val Leu Asn Ser Lys Ser Phe Ser Asn Val 
            100                 105                 110         


Ser Ser Thr Ile Phe Asn Lys Asn Lys Lys Val Asn Phe Asp Glu Thr 
        115                 120                 125             


Lys Lys Gly Asp Leu Ser Arg Lys Cys Leu Met Asn Ala Arg Asp Trp 
    130                 135                 140                 


Gly Val Leu Pro Leu Ile Ser Val Asp Asp Asp Ile Val Thr Cys Gly 
145                 150                 155                 160 


Thr Leu Lys Gly Ile Leu Ser Glu Cys Gln Ser Arg Ile Leu Ser Trp 
                165                 170                 175     


Asn Glu Cys Asn Leu Ser Thr Lys Glu Thr Tyr Ser Glu Lys Lys Ser 
            180                 185                 190         


Glu Tyr Gln Ser Ile Leu Asp Asp Ser Met Thr Lys Asp Ala Asp Val 
        195                 200                 205             


Thr Thr Ala Met Ile Gln Phe Met Asp Asp Val Ser Asn Val Tyr Gly 
    210                 215                 220                 


Ser Asn Asn Glu Asn Gln Leu Lys Trp Phe Asn Asn Arg Phe Leu Thr 
225                 230                 235                 240 


Tyr Val Arg Asn Lys Ile Arg Pro Phe Leu Leu Thr Asn Ser Pro Ile 
                245                 250                 255     


Asp Asn Phe Glu Gln Ser Asp Thr Ser Tyr Asn Cys Ser Ile Glu Ile 
            260                 265                 270         


Val Arg Ile Leu Ser Lys Tyr Glu Ile Leu Trp Lys Asp Glu Val Ser 
        275                 280                 285             


Val Asn Arg Tyr Lys Lys Thr Cys Asp Asp Gly Ile Asn Ile Glu Lys 
    290                 295                 300                 


Tyr Arg Tyr Leu Val His Ala Lys Ser Asp Phe Leu Arg Tyr Lys Glu 
305                 310                 315                 320 


Thr Ala Ser Phe Lys Glu Ile His Ala Val Lys Ser Pro Ile Ser Leu 
                325                 330                 335     


Cys Phe Gly Asn Asn Tyr Gln Pro Phe Ser Leu Ser Asp Val Gly Asp 
            340                 345                 350         


Arg His Asn Ile Asn Phe Gly Tyr Lys Phe Gly Lys Leu Gly Lys Gln 
        355                 360                 365             


Arg Lys Glu Cys Ser Phe Asn Leu Asn Tyr Arg Arg Lys Lys Val Lys 
    370                 375                 380                 


Tyr Ala Asn Thr Pro Val Arg Ser Asp Glu Asn Lys Cys Tyr Leu Asp 
385                 390                 395                 400 


Asn Leu Glu Ile Glu Asp Ala Lys Asn Gly Ser Tyr Lys Leu Ser Tyr 
                405                 410                 415     


Met Val Asn Lys Lys Tyr Lys Arg Glu Ser Phe Ile Lys Glu Pro Lys 
            420                 425                 430         


Met Lys Met Tyr Asn Gly Lys Leu Tyr Met Tyr Phe Pro Met Ser Asn 
        435                 440                 445             


Glu Phe Glu Glu Asp Arg Asp Ser Phe Ala Leu Leu Thr Tyr Phe Ser 
    450                 455                 460                 


Arg Ser Ser Asn Ser Lys Ser Gln Ile Asp Glu Ala Ser Asn Ile Leu 
465                 470                 475                 480 


Gln Asn Arg Lys Ile Arg Val Cys Gly Val Asp Leu Gly Ile Asn Pro 
                485                 490                 495     


Thr Phe Ala Leu Ser Val Leu Glu Tyr Ser Asp Asn Lys Ile Thr Asp 
            500                 505                 510         


Thr Asn Ile Gly Met Lys His Glu Gly Ser Tyr Asn Asn Phe Ser Glu 
        515                 520                 525             


Ile Arg Lys Gln Ile Asn Asp Val Thr Asp Met Ile Ser Tyr Leu Lys 
    530                 535                 540                 


Ser Lys Tyr Asp Asn Cys Glu Lys Asp Tyr Ser Ser Lys Ile Asp Asp 
545                 550                 555                 560 


His Ile Lys Ser Arg Leu Asn Glu Glu Ile Ser Asn Phe Cys Asp Leu 
                565                 570                 575     


Val Ser Tyr Lys Arg Asn Lys Asn Thr Ile Ile Arg Lys Glu Ile Lys 
            580                 585                 590         


Asn Val Glu Lys Glu Ile Asn Lys Ile Lys Asn Cys Arg Arg His Thr 
        595                 600                 605             


Leu Lys Lys Asp Leu Thr Glu Asn Phe Gly Trp Val Ser Ala Leu Asn 
    610                 615                 620                 


Glu Phe Ile Ser Leu Lys His Ser Phe Asn Asp Met Gly Glu Ser Phe 
625                 630                 635                 640 


Asp Ser Lys Thr Asn Pro Ser Tyr Ser Tyr Phe Glu Lys Trp Lys Arg 
                645                 650                 655     


Tyr Ile Asp Asn Ile Lys Asp Asp Ser Leu Lys Thr Val Ser Arg Glu 
            660                 665                 670         


Ile Leu Asn Phe Cys Ile Glu Asn Ser Val Asp Phe Ile Ala Leu Glu 
        675                 680                 685             


Asp Leu Gln Thr Phe Ala Pro Ser Asp Asp Arg Thr Lys Ser His Asn 
    690                 695                 700                 


Lys Leu Thr Gln Leu Trp Cys Phe Gly Lys Leu Lys Lys Cys Leu Glu 
705                 710                 715                 720 


Asp Ile Ala Ser Met Tyr Gly Ile His Val Tyr Ser Ser Thr Asp Pro 
                725                 730                 735     


Arg Asn Thr Ser Asp Thr His Phe Glu Ser Lys Asn Phe Gly Tyr Arg 
            740                 745                 750         


Asp Glu Ser Asn Lys His Asn Leu Trp Val Asn Val Asp Gly Glu Tyr 
        755                 760                 765             


Thr Val Val Asp Ser Asp Ile Asn Ala Ser Lys Asn Ile Ala Asn Arg 
    770                 775                 780                 


Phe Leu Thr His His Lys Asp Leu Lys Gln Leu Pro Met Ile Gly Asp 
785                 790                 795                 800 


Gly Thr Leu Phe Lys Ile Asp Ser Ser Ser Lys Arg Asn Lys Ser Phe 
                805                 810                 815     


Ala Val Lys Leu Asn Ile His Lys Asn Val Tyr Glu Leu Ile Asp Gly 
            820                 825                 830         


Glu Phe Val Lys Ser Asn Lys Lys Pro Asn Gly Thr Ser Arg Lys Gln 
        835                 840                 845             


Thr Ala Tyr Ile His Gly Asp Met Phe Ile Asp Ser Ile Ser His Lys 
    850                 855                 860                 


Asn Lys Lys Met Phe Leu Arg Glu Asn Leu Ile Arg Asn Gly Phe Ile 
865                 870                 875                 880 


Ser Lys Ser Arg Ala Asp Pro Lys Lys Lys Arg Lys Val 
                885                 890             


<210>  75
<211>  946
<212>  PRT
<213>  ˹

<220>
<223>  Cas12g.2-NLSںϵ׵İ

<400>  75

Met Asn Lys Thr Asp Thr Gln Asn Asn Glu Gln Ile Asn Lys Pro Thr 
1               5                   10                  15      


Gln Leu Leu Asn Asn Lys Asp Ile Glu Leu Thr Val Lys Thr Val Lys 
            20                  25                  30          


Ser Ala Thr Val Lys Val Asp Asn Asn Ser Lys Lys Glu Leu Phe Gly 
        35                  40                  45              


Leu Phe Asn Tyr Phe Thr Ser Val Ala Ser Gly Ile Lys Asp Lys Val 
    50                  55                  60                  


Tyr Asn Leu Gln Ser Asp Glu Lys Thr Ala Pro Ile Phe Asn Asp Tyr 
65                  70                  75                  80  


Val Lys Gln Pro Gln Arg Gly Arg Ser Ala Ala Thr Thr Leu Phe Thr 
                85                  90                  95      


Lys Leu Asp Ala Glu Lys Thr Tyr Thr Ser Gln His Ser Phe Pro Gly 
            100                 105                 110         


Lys Trp Arg Asp Ser Gly Ile Phe Pro Leu Tyr Asn Lys Glu Ser Glu 
        115                 120                 125             


Lys Tyr Asp Leu Ser Thr His Gly Tyr His Tyr Ser Ala Asn Ala Glu 
    130                 135                 140                 


Ile His Thr Gln Leu Asp Ser His Asp Glu Cys Asn Lys Glu Cys Glu 
145                 150                 155                 160 


Lys Glu Tyr Ala Ala Leu Arg Asp Glu Val Asn Asn Tyr Lys Tyr Glu 
                165                 170                 175     


Phe Thr Leu Gln Phe Lys Ala Glu Asn Ala Glu Lys Phe Tyr Asn Phe 
            180                 185                 190         


Val Glu Lys Leu Thr Leu Met Gly Trp Arg Tyr Asp Ala Thr Phe Arg 
        195                 200                 205             


Ser Phe Phe Glu Leu His Met His Pro Lys Leu Lys Thr Gly Glu Thr 
    210                 215                 220                 


Thr Tyr Arg Ala Thr Tyr Lys Leu Pro Ser Gly Lys Ser Lys Arg Tyr 
225                 230                 235                 240 


Ser Phe Phe Arg Asp Asp Ile Ala Asp Glu Ile Ala Lys Asn Pro Glu 
                245                 250                 255     


Phe Trp Pro Met Leu Glu Ser Ser Asn Ala Ile Ser Trp Ile Asn Ser 
            260                 265                 270         


Asn Asn Leu Leu Ser Arg Lys Lys Asp Lys Ala Asn Tyr Ser Ser Thr 
        275                 280                 285             


Ser Leu Ile Lys Ser Gln Ile Arg Leu Tyr Leu Gly Asn Asn Gly Val 
    290                 295                 300                 


Pro Phe Thr Ala Arg Glu His Asp Gly Arg Ile Tyr Phe Ser Phe Arg 
305                 310                 315                 320 


Leu Pro Ala Ile Asn Gly Glu Lys Gly Arg Met Val Glu Ile Pro Cys 
                325                 330                 335     


Ser Tyr Lys Lys Val Phe Asn Gly Lys Ala Arg Lys Ser Cys Tyr Leu 
            340                 345                 350         


Gly Gly Leu Thr Ile Glu Lys Thr Asp Ala Gly Lys His Ile Phe Lys 
        355                 360                 365             


Tyr Ser Val Asn Asn Lys Lys Pro Gln Val Ala Glu Leu Asn Glu Cys 
    370                 375                 380                 


Phe Leu Arg Leu Val Val Arg Asn Arg Glu Tyr Phe Asn Asn Val Val 
385                 390                 395                 400 


Ala Gly Lys Ile Thr Asp Ile Asn Thr Asp His Phe Asp Phe Tyr Val 
                405                 410                 415     


Asp Leu Pro Leu Asn Val Lys Glu Asp Pro Ile His Asp Leu Ser Ser 
            420                 425                 430         


Thr Glu Val Phe Gly Lys Asn Gly Leu Arg Ser Tyr Tyr Ser Ser Ala 
        435                 440                 445             


Tyr Pro Glu Ile Lys Asn Leu Gly Ser Gln Ile Glu Thr Gly Lys Asn 
    450                 455                 460                 


Leu Thr Cys Pro Ile Thr Lys Thr His Asn Ile Met Gly Ile Asp Leu 
465                 470                 475                 480 


Gly Gln Arg Asn Pro Phe Ala Tyr Cys Ile Lys Asp Asn Thr Gly Lys 
                485                 490                 495     


Leu Ile Ala Gln Gly His Met Asp Gly Ser Lys Asn Glu Thr Tyr Lys 
            500                 505                 510         


Lys Tyr Ile Asn Phe Gly Lys Glu Ser Thr Ser Val Ser His Leu Ile 
        515                 520                 525             


Lys Glu Thr Arg Ser Tyr Leu His Gly Asp Pro Glu Ala Ile Ser Lys 
    530                 535                 540                 


Glu Leu Tyr Asn Glu Val Ala Gly Phe Cys Asn Asn Pro Val Ser Tyr 
545                 550                 555                 560 


Glu Glu Tyr Leu Lys Tyr Leu Asp Ser Lys Lys Phe Leu Ile Asn Lys 
                565                 570                 575     


Glu Asp Leu Ser Lys Asn Ala Met His Leu Leu Arg Gln Lys Asp His 
            580                 585                 590         


Asn Trp Ile Gly Arg Asp Trp Leu Trp Tyr Ile Ser Lys Gln Tyr Lys 
        595                 600                 605             


Lys His Asn Glu Asn Arg Met Gln Asp Ala Asp Trp Arg Gln Thr Leu 
    610                 615                 620                 


Tyr Trp Ile Asp Ser Leu Tyr Arg Tyr Ile Asp Val Met Lys Ser Phe 
625                 630                 635                 640 


His Asn Phe Gly Ser Phe Tyr Asp Lys Asn Leu Lys Lys Lys Val Asn 
                645                 650                 655     


Gly Thr Val Val Gly Phe Cys Lys Thr Val His Asp Gln Ile Asn Asn 
            660                 665                 670         


Asn Asn Asp Asp Met Phe Lys Lys Phe Thr Asn Glu Leu Met Ser Val 
        675                 680                 685             


Ile Arg Glu His Lys Val Ser Val Val Ala Leu Glu Lys Met Asp Ser 
    690                 695                 700                 


Met Leu Gly Asp Lys Ser Arg His Thr Phe Glu Asn Arg Asn Tyr Asn 
705                 710                 715                 720 


Leu Trp Pro Val Gly Gln Leu Lys Thr Phe Met Glu Gly Lys Leu Glu 
                725                 730                 735     


Ser Phe Asn Val Ala Leu Ile Glu Ile Asp Glu Arg Asn Thr Ser Gln 
            740                 745                 750         


Val Cys Lys Glu Asn Trp Ser Tyr Arg Glu Ala Asp Asp Leu Tyr Tyr 
        755                 760                 765             


Val Thr Asp Gly Glu Ser His Lys Val His Ala Asp Glu Asn Ala Ala 
    770                 775                 780                 


Asn Asn Ile Val Asp Arg Cys Ile Ser Arg His Thr Asn Met Phe Ser 
785                 790                 795                 800 


Leu His Met Val Asn Pro Lys Asp Asp Tyr Tyr Val Pro Thr Cys Ile 
                805                 810                 815     


Trp Asp Thr Thr Glu Glu Ser Gly Lys Arg Val Arg Gly Phe Leu Thr 
            820                 825                 830         


Lys Leu Tyr Lys Asn Ser Asp Val Val Phe Thr Lys Lys Gly Asp Lys 
        835                 840                 845             


Leu Val Lys Ser Lys Thr Ser Val Lys Glu Leu Lys Lys Leu Val Gly 
    850                 855                 860                 


Lys Thr Lys Glu Lys Arg Gly Gln Tyr Trp Tyr Arg Phe Glu Gly Lys 
865                 870                 875                 880 


Ser Trp Ile Asn Glu Ala Asp Arg Asp Thr Ile Ile Leu Asn Ala Lys 
                885                 890                 895     


Lys Ile Ser Arg Glu Arg Asp Asn Gly Glu Gln Ser Thr Asp Thr Arg 
            900                 905                 910         


Ser Gln Asn Val Thr Val Ser Val Leu Asp Val Cys Glu Thr Ala Glu 
        915                 920                 925             


Lys Lys Lys Leu Val Leu Val Ser Arg Ala Asp Pro Lys Lys Lys Arg 
    930                 935                 940                 


Lys Val 
945     


<210>  76
<211>  898
<212>  PRT
<213>  ˹

<220>
<223>  Cas12h.1-NLSںϵ׵İ

<400>  76

Met Ala Leu Ile Gln Arg Ala Gly Val Leu Lys Thr Lys Ser Asp Phe 
1               5                   10                  15      


Pro Lys Val Ile Lys Asp Trp His Asp Ser Leu Leu Ala Asp Tyr Arg 
            20                  25                  30          


Lys Phe Phe Pro Ile Ile Phe Ser Trp Cys Pro Glu Tyr Gly Tyr Thr 
        35                  40                  45              


Thr Ile Gln Asp Asn Lys Pro Val Phe Val Ser Pro Glu Glu Arg Met 
    50                  55                  60                  


Glu Ser Ile Arg Lys Glu Ala Lys Glu His Leu Asn Glu Val Leu Ala 
65                  70                  75                  80  


Phe Gly Lys Met Ile Gly Ser Lys Gly Val Gly Gly Ser Ser Ser Tyr 
                85                  90                  95      


Ala Ile Phe Tyr Lys His His Lys Asn Asn Glu Asn Gly Ala Tyr Thr 
            100                 105                 110         


Pro Ser Arg Ala Lys Phe Met Lys Glu Gly Ile His Asn Arg Arg Val 
        115                 120                 125             


Glu Leu Val Asp Val Leu Met Leu Asn Ala Ile Pro Asp Glu Glu Trp 
    130                 135                 140                 


Val Lys Ile Ala Gln Glu Val Val Gly Tyr Ser Glu Glu Arg Leu Lys 
145                 150                 155                 160 


Leu Tyr Trp Asn Lys Phe Ile Ala Lys Arg Val Val Ser His Asp Arg 
                165                 170                 175     


Lys Leu Gly Lys Ile Val Arg Glu Lys Tyr Leu Glu Pro Lys Gly Leu 
            180                 185                 190         


Val Cys Ala Gln Pro Glu Asn Ser Thr Tyr Cys Arg Val Leu Thr Glu 
        195                 200                 205             


Ile Ile Lys Arg Gln Leu His Ser Gln Ile Glu Lys Ser Lys Phe His 
    210                 215                 220                 


Glu Glu Glu Leu Lys Ser Ile Glu Lys Thr Val Ser Glu Phe Asp Ser 
225                 230                 235                 240 


Pro Leu Leu Asp Phe Ile Cys Gln Tyr Ala Glu Glu Leu Asn Gln Ile 
                245                 250                 255     


Asn Ser Gly Leu Ser Lys Tyr Val Ile Lys Asn Ala Val Lys Glu Val 
            260                 265                 270         


Ile Ser Pro Pro Glu Lys Gln Ser Glu Ile Tyr Val Gln Ser Gln Val 
        275                 280                 285             


Leu Ser Gln Glu Lys Tyr Lys Pro Leu Val Asn Ala Thr Ile Lys Glu 
    290                 295                 300                 


Ile Leu Ser Gly Tyr Glu Gln Trp Lys Val Lys Ser Arg Tyr Glu Asn 
305                 310                 315                 320 


Arg Leu Lys Asn Arg Lys Tyr Val Leu Tyr Pro Lys Leu Ser Ala Asn 
                325                 330                 335     


Tyr Lys Ile Pro Ile Gly Gln Asn Ser Leu Gly Lys Phe Lys Ile Asn 
            340                 345                 350         


Val Ser Glu Asn Gly Glu Ile Val Ile Arg Leu Asn Asp Met Ala Asp 
        355                 360                 365             


Val Val Cys Met Pro Ser Lys Tyr Phe Phe Asn Leu Lys Ser Ser Pro 
    370                 375                 380                 


Val Val Asp Lys Lys Lys Gln Leu Val Gly Tyr Gln Ile Ser Phe Asn 
385                 390                 395                 400 


His Asn Ser Arg Arg Lys Glu Pro Thr Glu Lys Pro Asp Phe Asn Gly 
                405                 410                 415     


Ile Val Lys Glu Ile Gly Leu Gln Leu Lys Asp Asp Gly Arg Phe Tyr 
            420                 425                 430         


Ile Thr Leu Pro Tyr Cys Met Glu Tyr Ser Asn Asp Asn Phe Asp Leu 
        435                 440                 445             


Ile Arg Pro Leu Leu Thr Ser Ser Pro Thr Glu Asp Gln Ile Lys Lys 
    450                 455                 460                 


Met Pro Ser Glu Phe Asn Val Val Gly Phe Asp Leu Asn Leu Ser Met 
465                 470                 475                 480 


Pro Leu Pro Ile Thr Arg Ala Ile Val Gly Lys Ser Val Lys Gly Glu 
                485                 490                 495     


Ile Asn Val Glu Tyr Leu Gly Gln Ala Lys Val Ile Glu Ser Thr His 
            500                 505                 510         


Leu Ile Tyr Asp Asn Asn Arg Cys Lys Val Leu Ile Ala Tyr Lys Arg 
        515                 520                 525             


Gln Cys Asp Leu Ile Lys Arg Ala Ile Arg Glu Trp Lys Ile Cys Lys 
    530                 535                 540                 


Gly Lys Asn Ile Asp Ile Ser Glu Lys Thr Tyr Glu Trp Leu Glu Ser 
545                 550                 555                 560 


His Thr Lys Arg Trp Asn Pro Ser Arg Gln Pro Glu Ser Met Gln Asp 
                565                 570                 575     


Arg Phe Ser Val Ser Lys Met Arg Ile Gln Ile Leu Val Asn Lys Ala 
            580                 585                 590         


Lys Ser Arg Ile Ala Lys Tyr Asn Asp Asn Ser Trp Lys Thr Gly His 
        595                 600                 605             


Gly Asn Glu Ser Glu Leu Ile Arg Leu Ile Asp Ala Asp Asp Ala Tyr 
    610                 615                 620                 


Asn Ser Leu Val Ser Thr Tyr Asn Arg Ile His Leu Lys Ser Asn Gln 
625                 630                 635                 640 


Phe Ile Tyr Ala Leu Pro Ser Lys Asn Asn Ser Arg Ser Asn Lys Lys 
                645                 650                 655     


Glu Tyr Cys Leu Arg Arg Ile Ala Ala Lys Ile Ala Arg Tyr Cys His 
            660                 665                 670         


Leu His Asn Val Asn Ile Cys Ile Gly Glu Asn Leu Ser Phe Gln Gln 
        675                 680                 685             


Asp Ser Asp Asn Ile Ser Lys Asp Asn Ser Leu Val Arg Leu Phe Ser 
    690                 695                 700                 


Ser Lys Ser Ile Ala Asn Tyr Met Lys Leu Ala Met Glu Lys Phe Gly 
705                 710                 715                 720 


Ile Ala Phe Ile Asp Ser Ala Asp Pro Ser Gly Thr Ser Lys Thr Asp 
                725                 730                 735     


Pro Val Thr Gly Asn Ile Gly Tyr Arg Asn Lys Phe Asp Lys Arg Lys 
            740                 745                 750         


Leu His Val Ile Arg Asn Gly Asn Trp Gly Trp Val Asp Ser Asp Ile 
        755                 760                 765             


Ala Ala Ser Leu Asn Ile Leu Ile Arg Gly Ile Asn Arg Ser Ile Val 
    770                 775                 780                 


Pro Tyr Lys Phe Phe Val Gly Lys Lys Lys Gln Glu Ser Lys Arg Leu 
785                 790                 795                 800 


Asn His Phe Leu Asn Lys Ile Phe Gly Thr Thr Lys Val Phe Phe Tyr 
                805                 810                 815     


Glu Asp Gln Phe Gly Phe Ala Asn Pro Ser Leu Ser Lys Lys Glu Gly 
            820                 825                 830         


Glu Asn Leu Ile Ala Asn Gln Tyr Leu Tyr Tyr Arg Glu Gly Lys Phe 
        835                 840                 845             


Val Thr Gln Lys Ile His Arg Gln Ile Glu Asp Asp Phe Lys Lys Ile 
    850                 855                 860                 


Asp Phe Ser Asn Thr Pro Glu Val Asn Leu Ile Pro Ser Gly Val Lys 
865                 870                 875                 880 


Leu Lys Asn Phe Gln Phe Glu Ser Arg Ala Asp Pro Lys Lys Lys Arg 
                885                 890                 895     


Lys Val 
        


<210>  77
<211>  932
<212>  PRT
<213>  ˹

<220>
<223>  Cas12h.2-NLSںϵ׵İ

<400>  77

Met Ala Thr Arg Ser Phe Ile Arg Thr Gly Asn Leu Lys Ala Lys Asn 
1               5                   10                  15      


Thr Ala Glu Glu Val Met Gln Trp Tyr Ala Asp Leu Gln Ser Asp Tyr 
            20                  25                  30          


Arg Ser Phe Leu Asn Leu Phe Phe Gly Trp Met Ala Ile Gly Tyr Gly 
        35                  40                  45              


Thr Asn Ala Glu Asp Glu Val Phe Tyr Thr Ser Lys Glu Glu Ser Glu 
    50                  55                  60                  


Arg Leu Arg Ser Leu Thr Ile Gly Asp Ala Lys Lys Glu Gln Leu Ala 
65                  70                  75                  80  


Val Ser Phe Ile Glu Leu Leu Leu Lys Gly Gly Glu Asn Ala Ser Ser 
                85                  90                  95      


Cys Tyr Asn Val Phe Tyr Arg Asn Tyr Lys Ser Leu Gly Lys Ala Lys 
            100                 105                 110         


Leu Thr Gln Lys Lys Asn Asp Phe Leu Ser Ala Leu Pro Leu Leu Asp 
        115                 120                 125             


Glu Asn Lys Ile Lys Glu Tyr Phe Lys Thr Asp Glu Gln Leu Ser Gln 
    130                 135                 140                 


Ile Cys Ile Glu Glu Trp Leu Glu Tyr Gly Val Lys Asn Leu Pro Leu 
145                 150                 155                 160 


Pro Glu Ile Trp Ala Glu Val Ser Pro Arg Leu Ala Ser Ile Glu Arg 
                165                 170                 175     


Ser Leu Gly Val Asp Leu Arg Leu Ala Phe Gly Leu Ser Cys Ile Arg 
            180                 185                 190         


Ser Arg Asp Cys Asn Tyr Cys Arg Ile Leu Ile Glu Met Val Gly Arg 
        195                 200                 205             


Asp Leu Arg Ser Ile Phe Glu Lys Tyr Asn Asn His Leu Leu Glu Thr 
    210                 215                 220                 


Glu Lys Ile Lys Leu Ser Met Asn Asp Lys Gln Gly Pro Val Tyr Asp 
225                 230                 235                 240 


Ser Ile Cys Cys Phe Ala Ala Glu Leu Glu Ser Lys Asn Ser Gly Leu 
                245                 250                 255     


Thr Lys Tyr Val Leu Thr Lys Gly Ile Asp His Val Lys Lys Gly Thr 
            260                 265                 270         


Gly Glu Lys Thr Asp Ile Arg Leu Ala Val Lys Glu Leu Lys Lys Asn 
        275                 280                 285             


Lys Tyr Arg Ile Leu Ile Glu Ser Ser Tyr Ser Glu Ile Met Ser Ala 
    290                 295                 300                 


Tyr Ser Cys Trp Arg Thr Lys Lys Gln Leu Glu Lys Arg Lys Leu Tyr 
305                 310                 315                 320 


Pro Cys Phe Asp Pro Asn Arg Asn Asp Tyr Lys Val Pro Val Gly Gln 
                325                 330                 335     


Gly Ser Leu Gly Asn Phe Thr Val Ser Val Glu Asp Ser Gly Asp Val 
            340                 345                 350         


Leu Ile Glu Ile Val Gly Val Gly Val Ile Arg Cys Ala Ala Ser Cys 
        355                 360                 365             


Tyr Phe Ser Gly Ile Val Phe Asp Glu Ile Arg Asn Lys Asn Gly Arg 
    370                 375                 380                 


Thr Gly Tyr Ser Leu Asn Phe Cys His Lys Ser Ile Ser Lys Gly Lys 
385                 390                 395                 400 


Lys Ala Val Lys Ala Ala Ser His Thr Gly Asp Lys Ile Ser Gly Val 
                405                 410                 415     


Leu Lys Glu Ile Gly Leu Arg Asn Thr Asp Ser Gly Phe Phe Val Ser 
            420                 425                 430         


Leu Pro Tyr Ser Ile His His Asp Glu Lys Asn Phe Lys Ile Ala Glu 
        435                 440                 445             


Phe Phe Met Ser Ala Cys Pro Lys Lys Glu Asn Val Glu Asn Leu Pro 
    450                 455                 460                 


Asp Lys Ile Val Val Gly Ala Ile Asp Leu Asn Val Ser Asn Pro Val 
465                 470                 475                 480 


Ala Ala Val Lys Ala Val Val Tyr Arg Asp Asp Lys Ser Gly Gln Leu 
                485                 490                 495     


Asn Ala Leu Asp Tyr Gly Ser Gly Asn Leu Ile Lys Lys Pro Phe Met 
            500                 505                 510         


Leu Val Ala Asn Gly Pro Arg Ile Lys Asn Leu Ile Glu Ile Arg Asp 
        515                 520                 525             


Asp Ala Arg Arg Val Ile Gly Ala Ile Arg Glu Phe Lys Val Ser Asn 
    530                 535                 540                 


Ala Val Lys Glu His Val Gly Glu Asp Thr Arg Asp Phe Leu Ile Leu 
545                 550                 555                 560 


Cys Gly Asp Thr Lys Ser Ser Ser Thr Arg Tyr Leu Ile Gln Ser Trp 
                565                 570                 575     


Val Lys Lys Ile Asn Ser Arg Leu Arg Lys Ile Lys Phe Glu Met Arg 
            580                 585                 590         


Ser Gly Gly Tyr Arg Asp Cys Ala Asp Asn Ile Arg Leu Ile Glu Ala 
        595                 600                 605             


Met Asp Gln Cys Ala Ser Met Ala Glu Ser Tyr Asn Arg Ile His Leu 
    610                 615                 620                 


Lys Ser Gly Glu Lys Leu Val Lys Val Ala Lys Phe Asp Lys Ser Arg 
625                 630                 635                 640 


Ala Asn Phe Arg Asn Phe Val Leu Arg Gln Leu Ala Ser Lys Ile Ala 
                645                 650                 655     


Asn Glu Met Lys Asp Cys Asn Val Val Phe Gly Glu Asp Leu Asp Phe 
            660                 665                 670         


Ile Phe Asp Ser Asp Lys Asn Asn Asn Ala Leu Leu Arg Leu Phe Ser 
        675                 680                 685             


Ala Ala Thr Leu Leu Lys Tyr Ile Ile Glu Ala Leu Glu Lys Ile Gly 
    690                 695                 700                 


Val Gly Phe Val Lys Val Ala Lys Asn Gly Thr Ser Gln Ser Asp Pro 
705                 710                 715                 720 


Val Thr Ser Asn Pro Gly Trp Arg Asp Asp Lys Asn Lys Ser Arg Leu 
                725                 730                 735     


Tyr Val Val Arg Asp Lys Gln Leu Gly Trp Ile Asp Ser Asp Leu Ala 
            740                 745                 750         


Ala Thr Met Asn Ile Leu Ile Gln Gly Leu Asn His Ser Val Cys Pro 
        755                 760                 765             


Tyr Lys Phe Tyr Val Lys Glu Tyr Glu Asn Lys Pro Asn Ser Thr Gln 
    770                 775                 780                 


Asp Ser Ile Asn Ala Ile Lys Lys Pro Glu Glu Ala Ile Gly Lys Arg 
785                 790                 795                 800 


Ile Lys Arg Phe Phe Asn Leu Lys Tyr Gly Ser Ser Val Pro Lys Phe 
                805                 810                 815     


Val Ser Asp Asp Arg Gly Arg Val Thr Phe Ala Lys Lys Ile Asp Ser 
            820                 825                 830         


Thr Gln Thr Arg Leu Ile Asn Gln Phe Val Tyr Ala His Ser Ser Cys 
        835                 840                 845             


Ile Val Thr Cys Glu Leu His Asn Glu Met Val Asn Lys Ile Lys Gln 
    850                 855                 860                 


Leu Ala Val Glu Lys Pro Asn Cys Gln Glu Phe Asp Val Thr Cys Asp 
865                 870                 875                 880 


Pro Asp Gly Arg Tyr Asn Asn Phe Ala Leu Pro Glu Val His Asp Ser 
                885                 890                 895     


Ser Lys Asp Val Gly Ala Lys Ala Leu Thr Thr Lys Asp Val Asp Phe 
            900                 905                 910         


Lys Thr Ile Leu Lys Asp His Thr Ala Ser Arg Ala Asp Pro Lys Lys 
        915                 920                 925             


Lys Arg Lys Val 
    930         


<210>  78
<211>  1308
<212>  PRT
<213>  ˹

<220>
<223>  Cas12w.1-NLSںϵ׵İ

<400>  78

Met Gly Lys Asn Glu Asn Lys Tyr Gln Leu Ser Lys Thr Leu Arg Phe 
1               5                   10                  15      


Gly Leu Thr Leu Lys Glu Lys Ile Ser Asn Asn Glu Lys Thr Pro Tyr 
            20                  25                  30          


Gln Ser His Ser Gln Phe Arg Asp Leu Ile Ile Leu Ser Glu Asn Arg 
        35                  40                  45              


Ile Arg Glu Gly Ile Ser Thr Pro Gln Asn Arg Asp Leu Pro Ser Phe 
    50                  55                  60                  


Ile His Arg Ile Gln Asn Cys Thr Asp Phe Ile Asn Asp Phe Ile His 
65                  70                  75                  80  


Asp Trp Trp Met Ile Leu Met His Thr Gly Gln Ile Glu Leu Asp Lys 
                85                  90                  95      


Asp Tyr Tyr Lys Ser Leu Thr Lys Lys Val Gly Phe Val Gly Phe Trp 
            100                 105                 110         


Tyr Lys Glu Asn Lys Lys Lys Gly Gly Lys Thr Lys Gln Pro Gln Ala 
        115                 120                 125             


Arg Asn Ile Pro Met Gly Glu Leu Arg His Leu Cys Pro Gln Asn Thr 
    130                 135                 140                 


Lys Glu Cys Ala Thr Tyr Ile Thr Asp Tyr Trp Lys Asp Leu Leu Ile 
145                 150                 155                 160 


Thr Ala Thr Asn Lys Leu Tyr Glu Ser Ser Glu Gln Gln Lys Lys Phe 
                165                 170                 175     


Ile Lys Ala Met Glu Gln Asn Arg Thr Asp Asn Lys Pro Asn Glu Ile 
            180                 185                 190         


Asp Leu Lys Lys Ser Phe Leu Ser Leu Val Ser Val Thr Met Glu Leu 
        195                 200                 205             


Leu Asn Pro Ile Leu Asn Gly Gln Ile Leu Phe Asn Lys Met Asp Arg 
    210                 215                 220                 


Leu Asp Met Ser Lys Lys Ser Asp Asn Asp Phe Ile Asp Phe Val Asn 
225                 230                 235                 240 


Asp His Glu Thr Val Arg Glu Leu Asn Asn Asp Ile Glu Glu Ile Ile 
                245                 250                 255     


Ala Asp Phe Lys Glu Asn Gly Asn Asn Val Asn Tyr Cys Lys Ala Thr 
            260                 265                 270         


Leu Asn Pro Asp Thr Ala Leu Lys Gln His Asn Asn Asn Ile Pro Asn 
        275                 280                 285             


Asp Ile Ala Thr Asp Leu Glu Glu Leu Met Met Asp Ser Ile Val Gly 
    290                 295                 300                 


Asn Tyr Asp Asp Val Asn Ser Phe Met Asp Asn Tyr Val Ser Asn Leu 
305                 310                 315                 320 


Ser Ala Lys Asp Lys Ile Lys Lys Ile Lys Asp Ser Asn Ile Ser Leu 
                325                 330                 335     


Ile Tyr Arg Ala Ile Leu Phe Lys Tyr Lys Met Ile Pro Ala Asn Val 
            340                 345                 350         


Arg Arg Asp Ile Ala Gln Gly Met Ala Lys Lys Leu Asn Lys Asp Glu 
        355                 360                 365             


Glu Asn Ile Tyr Ser Phe Leu Cys Glu Phe Gly Thr Leu Arg Thr Pro 
    370                 375                 380                 


Gln Lys Asp Tyr Ala Asp Leu Lys Asp Lys Asp Ser Phe Asn Leu Asp 
385                 390                 395                 400 


Asn Tyr Pro Leu Lys Val Ala Phe Asp Phe Ala Trp Glu Gly Leu Ala 
                405                 410                 415     


Lys Ala Trp Tyr His Asp Gln Ser Asp Phe Pro Ile Asp Pro Cys Arg 
            420                 425                 430         


Asp Phe Leu Gln Glu Asn Phe Asp Val Asn Leu Glu Glu Asp Gln Glu 
        435                 440                 445             


Asp Glu Tyr Phe Leu Leu Tyr Ala Asp Leu Ile Glu Leu Asn Ala Leu 
    450                 455                 460                 


Leu Ser Thr Leu Asp Lys Gly Asn Pro Ala Asp Pro Asp Ser Ile Lys 
465                 470                 475                 480 


Asn Glu Ala Leu Glu Met Val Glu Tyr Ile Asn Trp Asn Ser Leu Asp 
                485                 490                 495     


Lys Lys Asn Gly Asn Tyr Tyr Lys Lys Ile Ile Lys Asn Arg Leu Lys 
            500                 505                 510         


Ser Ser Lys Gly Asn Glu Thr Tyr Glu Arg Ile Lys Lys Glu Ile Ser 
        515                 520                 525             


Met Ser Arg Gly Arg Leu Lys Asn Lys Ile Glu Lys Tyr Asp Asp Leu 
    530                 535                 540                 


Thr Ser Gln Tyr Lys Arg Ile Ala Met Asp Leu Gly Lys Lys Phe Ala 
545                 550                 555                 560 


Ser Leu Arg Asp Lys Ile Ile Ala Ala Asn Glu Asp Asn Lys Val Thr 
                565                 570                 575     


His Tyr Ala Met Ile Leu Glu Asp Ser Asn Cys Asp Lys Tyr Leu Leu 
            580                 585                 590         


Leu Gln Lys Val Ser Asn Asn Ile Tyr His Cys Met Ser Tyr Asp Ser 
        595                 600                 605             


Ser Asp Pro Lys Ala Tyr Tyr Val Asp Ser Ile Thr Ser Ser Ala Ile 
    610                 615                 620                 


Ala Lys Met Ile Arg Lys Glu Thr Asn Pro Ser Lys Ile Arg Glu Tyr 
625                 630                 635                 640 


Ala Glu Leu Glu Glu Lys Glu Arg Glu Arg Arg Asn Val Asp Asp Trp 
                645                 650                 655     


Cys Arg Phe Ile Ser Lys Lys Glu Tyr Asp Arg Arg Tyr Gln Leu Asn 
            660                 665                 670         


Ile Asn Asn Gly Leu Ser Phe Glu Ala Leu Lys Lys Glu Ile Asp Ser 
        675                 680                 685             


Lys Ser Tyr Ile Leu Val Lys Lys Asn Ile Ser Val Asp Ser Ile Arg 
    690                 695                 700                 


Glu Leu Val Glu Asn Glu Gly Cys Leu Leu Phe Pro Ile Val Asn Lys 
705                 710                 715                 720 


Asp Leu Thr Lys Glu Arg Lys Thr Thr Glu Asp Asn Gln Phe Thr Lys 
                725                 730                 735     


Asp Trp Asn Met Ile Phe Ser Gly Ser Glu Thr Asn Trp Arg Leu Thr 
            740                 745                 750         


Pro Glu Phe Arg Val Thr Tyr Arg Asn Pro Val Pro Gly Tyr Pro Asn 
        755                 760                 765             


Asp Lys Phe Gly Ser Lys Arg Tyr Ser Arg Phe Gln Met Asn Ala His 
    770                 775                 780                 


Phe Val Cys Asp Phe Ile Pro Ser Ser Asn Ser Tyr Thr Ser Asn Arg 
785                 790                 795                 800 


Glu Gln Ile Ala Ile Phe Lys Asp Glu Gly Glu Gln Lys Lys Arg Val 
                805                 810                 815     


Glu Glu Phe Asn Arg Thr Leu Ser Asn Ile Asn Gln Lys Phe Tyr Val 
            820                 825                 830         


Ile Gly Ile Asp Arg Gly Gln Lys Glu Leu Ala Thr Leu Cys Val Val 
        835                 840                 845             


Asp Gln Asp Lys Lys Ile His Gly Asp Phe Lys Ile Tyr Thr Arg Lys 
    850                 855                 860                 


Phe Asn Ser Glu Arg Lys Gln Trp Glu His Tyr Ser Leu Glu Gly Glu 
865                 870                 875                 880 


Lys Gly Thr Arg Asn Ile Leu Asp Leu Ser Asn Leu Arg Val Glu Thr 
                885                 890                 895     


Thr Ile Ile Ile Asp Gly Lys Pro Glu Arg Arg Gln Val Leu Val Asp 
            900                 905                 910         


Leu Ser Glu Val Leu Val Lys Asp Lys Glu Gly Asn Tyr Thr Lys Pro 
        915                 920                 925             


Asn Lys Met Gln Ile Lys Met Gln Gln Met Ala Tyr Val Arg Lys Leu 
    930                 935                 940                 


Gln Phe Gln Met Gln Ala Asn Pro Thr Glu Val Leu Glu Trp Tyr Glu 
945                 950                 955                 960 


Gln Asn Pro Thr Glu Glu Leu Ile Ile Lys Asn Leu Val Asp Lys Glu 
                965                 970                 975     


Asn Gly Glu Lys Gly Leu Ile Ser Phe Tyr Gly Thr Ala Leu Val Glu 
            980                 985                 990         


Leu Asp Gln Thr Leu Pro Val Ser  Lys Ile Lys Glu Met  Leu Glu Glu 
        995                 1000                 1005             


Phe Lys  Ile Leu Lys Gln Arg  Glu Ser Lys Lys Glu  Asn Val Gln 
    1010                 1015                 1020             


Lys Glu  Leu Asn Asn Leu Thr  Gln Leu Glu Ala Val  Asp Ser Leu 
    1025                 1030                 1035             


Lys Ala  Gly Ile Val Ala Asn  Met Val Gly Val Ile  Ser Tyr Ile 
    1040                 1045                 1050             


Leu Lys  Thr Leu Asp Tyr Asn  Ala Tyr Ile Ser Leu  Glu Asp Leu 
    1055                 1060                 1065             


Ser Thr  Val Gln Ser Ser Thr  Glu Phe Ala Ser Gly  Ile Ser Gly 
    1070                 1075                 1080             


Ala Ile  Thr Lys Met Ser Arg  Glu Glu Gly Arg Arg  Ile Asp Val 
    1085                 1090                 1095             


Glu Lys  Tyr Ala Gly Leu Gly  Leu Tyr Asn Phe Phe  Glu Met Gln 
    1100                 1105                 1110             


Leu Leu  Arg Lys Leu His Arg  Ile Gln Thr Asp Asn  Gly Asn Ile 
    1115                 1120                 1125             


Leu His  Leu Val Pro Ala Phe  Arg Ala Gln Lys Asn  Tyr Asp His 
    1130                 1135                 1140             


Ile Met  Val Gly Lys Glu Lys  Ile Lys Asn Gln Phe  Gly Ile Val 
    1145                 1150                 1155             


Phe Phe  Val Asp Ala Ala Ala  Thr Ser Ile Lys Cys  Pro Arg Cys 
    1160                 1165                 1170             


Gly Ala  Val Asn Glu Asp Lys  Phe Asn Pro Asp Lys  Gln Lys Tyr 
    1175                 1180                 1185             


Pro Asp  Ala Glu Lys Gly Pro  Lys Leu Arg Asn Arg  Lys Glu Gln 
    1190                 1195                 1200             


Ser Gly  Lys Lys Val Trp Val  Thr Arg Asp Lys Glu  Asp Asp Asp 
    1205                 1210                 1215             


Arg Ile  Lys Cys Tyr Cys Cys  Gly Phe Asp Thr Lys  Glu Lys Asn 
    1220                 1225                 1230             


Glu Gly  Asn Pro Phe Met Tyr  Ile Lys Ser Gly Asp  Asp Asn Ala 
    1235                 1240                 1245             


Ala Tyr  Leu Ile Ser Asp Leu  Gly Val Glu Ser Tyr  Arg Lys Ala 
    1250                 1255                 1260             


Tyr Glu  Leu Ala Ala Thr Val  Val Glu Asp Arg Lys  Lys Thr Leu 
    1265                 1270                 1275             


Thr Asn  Asn Leu Asn Gln Ser  Asn Tyr Lys Ile Arg  Phe Leu Trp 
    1280                 1285                 1290             


His Thr  Met Tyr Ser Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val 
    1295                 1300                 1305             


<210>  79
<211>  1268
<212>  PRT
<213>  ˹

<220>
<223>  Cas12w.2-NLSںϵ׵İ

<400>  79

Met Asp Ala Asp Lys Thr Thr Lys Ala Ile Asn Glu Tyr Gln Thr Gln 
1               5                   10                  15      


Lys Thr Ile Arg Phe Gly Leu Thr Ala Thr Asn Gln Asn Leu Tyr Ser 
            20                  25                  30          


Glu Glu Ile Met Lys Leu Leu Asn Ile Ser Glu Glu Arg Ile Ile Lys 
        35                  40                  45              


Glu Lys Val Lys Val Asn Asn Asp Thr Asp Lys Thr Asn Gln Leu Arg 
    50                  55                  60                  


Gly Cys Leu Val Gln Ile Lys Lys Tyr Leu Lys Thr Trp Glu Asn Ile 
65                  70                  75                  80  


Tyr Ala Gln Ile Asp Phe Leu Ala Ile Thr Lys Asp Tyr Tyr Lys Val 
                85                  90                  95      


Ile Ser Lys Lys Ala Arg Phe Asp Phe Asp Lys Gly Asn Gly Ser Glu 
            100                 105                 110         


Ile Lys Leu Ser Ser Leu Gln Ser Thr His Asn Lys Lys Lys Arg Tyr 
        115                 120                 125             


Gln Tyr Ile Ile Asp Phe Trp Lys Glu Asn Leu Arg Lys Thr Glu Asn 
    130                 135                 140                 


Leu Tyr Arg Lys Ser Asp Asp Leu Leu Lys Ile Phe Glu Glu Ala Lys 
145                 150                 155                 160 


Asn Gln Asn Arg Asp Asp Lys Lys Leu Asn Lys Val Glu Leu Arg Lys 
                165                 170                 175     


Thr Phe Leu Asn Leu Phe Thr Leu Val Asn Glu Ser Leu Lys Pro Leu 
            180                 185                 190         


Ile Glu Gly Asn Leu Phe Ile Val Asn Asp Asp Lys Ile Asp Glu Lys 
        195                 200                 205             


Asn Ser Lys His Asn Tyr Val Phe Tyr Phe Ile Ser Lys Thr Glu Glu 
    210                 215                 220                 


Arg Arg Leu Leu Tyr Asp Asn Ile Cys Thr Leu Gln Asp Tyr Phe Lys 
225                 230                 235                 240 


Asn Asn Gly Gly Tyr Val Pro Phe Gly Arg Val Thr Leu Asn Lys Trp 
                245                 250                 255     


Thr Ala Leu Gln Lys Phe Asn Asn Arg Asp Ile Glu Ile Asn Arg Ile 
            260                 265                 270         


Ile Lys Glu Leu Lys Ile Asn Asn Ile Ser Thr Gln Lys Thr Asp Tyr 
        275                 280                 285             


Lys Tyr Asn Asp Phe Thr Glu Asn Phe Lys Glu Lys Lys Asp Glu Asn 
    290                 295                 300                 


Gly Lys Val Val Lys Asn Ser Ala Gly Asn Ile Ile Trp Asp Leu Lys 
305                 310                 315                 320 


Ala Asn Ala Lys Ser Val Ile Glu Ile Cys Gln Phe Phe Lys Tyr Lys 
                325                 330                 335     


Lys Val Pro Ile Asn Ala Arg Leu Asn Leu Ala Lys Arg Leu Ile Lys 
            340                 345                 350         


Asp Asn Lys Leu Lys Lys Glu Gln Glu Asn Thr Phe Leu Ser Glu Phe 
        355                 360                 365             


Gly Val Leu Lys Thr Pro Ala Phe Asp Tyr Ala Arg Asp Lys Glu Asn 
    370                 375                 380                 


Phe Asn Leu Thr Asn Tyr Pro Leu Lys Val Ala Phe Asp Tyr Ala Trp 
385                 390                 395                 400 


Glu Asn Cys Ala Lys Asp Lys Tyr Glu Lys Ile Pro Phe Pro Lys Glu 
                405                 410                 415     


Gln Cys Glu Arg Tyr Leu Gln Thr Ala Phe Glu Ile Asp Ala Thr Lys 
            420                 425                 430         


Asp Glu Asn Lys Lys Leu Ile Asp Thr His Leu Asn Lys Tyr Ala Asp 
        435                 440                 445             


Leu Leu Gln Phe Lys Ile Leu Leu Glu Arg Phe Lys Ala Glu Phe His 
    450                 455                 460                 


Lys Thr Asn Glu Glu Thr Asn Lys Asn Asn Ile Gln Lys Leu Arg Asn 
465                 470                 475                 480 


Val Phe Ser Gly Leu Asp Tyr His Gly Asp Asn Arg Leu Asn Lys Asn 
                485                 490                 495     


Gln Ile Gln Lys Ala Ile Glu Ala Trp Phe Asp Asn Lys Glu Gln Asn 
            500                 505                 510         


Ile Gly Lys Lys Lys Glu Asn Glu Lys Leu Leu Thr Glu Asn Glu Lys 
        515                 520                 525             


Asn Asn Phe Ser Leu Ser Met Gln Ile Ile Gly Gln Glu Arg Gly Gly 
    530                 535                 540                 


Leu Lys Asn Gly Ile Pro Lys Tyr Lys Glu Leu Thr Glu Met Phe Lys 
545                 550                 555                 560 


Val Cys Ala Ser Lys Phe Gly Lys Gln Phe Ala Asp Leu Arg Asp Tyr 
                565                 570                 575     


Phe Asn Glu Ala Tyr Glu Val Asp Lys Ile Lys Tyr Arg Ala Trp Ile 
            580                 585                 590         


Ile Glu Asp Asp Lys Lys Asn Arg Phe Val Leu Phe Val Asn Lys Glu 
        595                 600                 605             


Lys Ala Phe Asp Leu Thr Ser Glu Glu Gly Asp Leu Trp Phe Tyr Glu 
    610                 615                 620                 


Val Lys Ser Leu Thr Ser Lys Ser Leu Val Lys Phe Ile Lys Asn Arg 
625                 630                 635                 640 


Gly Ala Tyr Pro Asp Phe His Asp Val Lys Asn Ser Phe His Tyr Ser 
                645                 650                 655     


Ser Ile Lys Lys Asp Trp Gln Asn Tyr Lys Asn Asp Pro Glu Phe Leu 
            660                 665                 670         


Asp Lys Leu Lys Glu Cys Leu Lys Asn Ser Lys Ile Ala Lys Asp Gln 
        675                 680                 685             


Lys Trp Ala Lys Phe Cys Trp Asp Phe Lys Gln Cys Asp Thr Tyr Glu 
    690                 695                 700                 


Lys Leu Glu Lys Glu Val Asp Arg Lys Gly Tyr Lys Leu Glu Gly Cys 
705                 710                 715                 720 


Lys Ser Glu Pro Lys Thr Ile Ser Leu Thr Gln Leu Thr Asp Trp Val 
                725                 730                 735     


Glu Asn Lys Asp Cys Phe Leu Leu Pro Ile Val Asn Gln Asp Ile Asn 
            740                 745                 750         


Lys Gly Asp Lys Arg Thr Lys Asn Gln Asn Gln Phe Thr Lys Asp Trp 
        755                 760                 765             


Phe Asp Ile Phe Glu Asn Lys Lys Arg Leu His Pro Glu Phe Asn Ile 
    770                 775                 780                 


Phe Tyr Arg Phe Pro Thr Lys Asp Tyr Pro Asn Thr Lys Phe Lys Asn 
785                 790                 795                 800 


Gly Thr Glu Lys Thr Lys Arg Tyr Ser Arg Phe Gln Met Leu Ala Tyr 
                805                 810                 815     


Phe Gly Cys Glu Val Ile Pro Ser Gly Asn His Leu Ser Lys Lys Glu 
            820                 825                 830         


Gln Ile Ala Ile Phe Asn Asn Asp Lys Lys Gln Lys Glu Glu Val Glu 
        835                 840                 845             


Lys Tyr Asn Lys Ser Ile Ser Ser Asp Cys Asp Tyr Val Ile Gly Ile 
    850                 855                 860                 


Asp Arg Gly Ile Lys Gln Leu Ala Thr Leu Cys Val Leu Asp Lys Asn 
865                 870                 875                 880 


Gly Val Ile Gln Gly Asp Phe Gln Ile Phe Thr Arg Thr Phe Asn Lys 
                885                 890                 895     


Gln Thr Lys Gln Trp Glu His Lys Glu Leu Glu Gln Arg Asn Ile Leu 
            900                 905                 910         


Asp Leu Ser Asn Leu Arg Val Glu Thr Thr Ile Thr Gly Lys Lys Val 
        915                 920                 925             


Leu Val Asp Leu Ser Lys Ile Lys Asp Asp Glu Gly Asn Tyr Thr Asn 
    930                 935                 940                 


Leu Lys Gln Thr Ile Lys Leu Lys Gln Leu Ala Tyr Ile Arg Glu Leu 
945                 950                 955                 960 


Gln Tyr Ala Met Gln Thr Arg Pro Asp Asp Leu Leu Asp Phe Val Lys 
                965                 970                 975     


Ser Ile Asn Ser Ala Asn Asp Ile Thr Ala Glu Asn Ile Lys His Phe 
            980                 985                 990         


Ile Ser Pro Tyr Lys Glu Gly Lys  Asn Tyr Asp Asp Leu  Pro Lys Val 
        995                 1000                 1005             


Glu Met  Phe Asn Leu Leu Lys  Glu Trp Gly Asn Ala  Asp Glu Asn 
    1010                 1015                 1020             


Gly Lys  Arg Lys Ile Ala Glu  Leu Asp Pro Ala Asp  Asn Leu Lys 
    1025                 1030                 1035             


Ser Gly  Ile Val Ala Asn Met  Val Gly Val Val Ala  Phe Leu Cys 
    1040                 1045                 1050             


Glu Asn  Tyr Asn Tyr Lys Val  Arg Ile Ala Leu Glu  Asp Leu Thr 
    1055                 1060                 1065             


Arg Ala  Tyr Gly Ile Gln Lys  Asp Ala Leu Asn Gly  Thr Ala Ile 
    1070                 1075                 1080             


Tyr Gln  Asn Asp Glu Asp Phe  Lys Glu Gln Glu Asn  Arg Arg Leu 
    1085                 1090                 1095             


Ala Gly  Val Gly Thr Met Gln  Phe Phe Glu Val Gln  Leu Leu Arg 
    1100                 1105                 1110             


Lys Leu  Phe Lys Ile Gln Val  Asp Lys Asn Leu His  Leu Ile Pro 
    1115                 1120                 1125             


Ala Phe  Arg Ser Val Asp Asn  Tyr Glu Lys Ile Val  Arg Arg Asp 
    1130                 1135                 1140             


Lys Gln  Asn Ser Gly Asp Glu  Phe Val Asn Tyr Pro  Phe Gly Ile 
    1145                 1150                 1155             


Val Cys  Phe Val Asp Pro Lys  Tyr Thr Ser Gln Gln  Cys Pro Tyr 
    1160                 1165                 1170             


Cys Asn  Asn Thr His Lys His  Lys Lys Asn Asp Thr  Glu Thr Gly 
    1175                 1180                 1185             


Lys Lys  Ala Phe Tyr Arg Asn  Lys Gly Glu Asn Lys  Asn Ser Leu 
    1190                 1195                 1200             


Leu Cys  Glu Lys Cys Gly Val  Ser Thr Ile Glu Gly  Glu Glu Thr 
    1205                 1210                 1215             


Leu Ser  Ser Lys Asn Asp Asn  Lys Lys Gln Phe Asn  Ile His Tyr 
    1220                 1225                 1230             


Ile Thr  Asp Gly Asp Gln Asn  Gly Ala Tyr His Ile  Ala Asn Lys 
    1235                 1240                 1245             


Val Val  Ile Asn Phe Gln Lys  Asp Ser Ser Arg Ala  Asp Pro Lys 
    1250                 1255                 1260             


Lys Lys  Arg Lys Val 
    1265             


<210>  80
<211>  1022
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.1-NLSںϵ׵İ

<400>  80

Met Asp Tyr Gln Gln Tyr Glu Phe Thr Arg Thr Ile Arg Phe Asn Leu 
1               5                   10                  15      


Ser Gly Asp Asp Lys Arg Ala Leu Met Leu Asp Leu Leu Asp Asp Thr 
            20                  25                  30          


Gln Glu Gly Met Leu Ala Ala Phe Gln Glu Thr Tyr Lys Asn Leu Leu 
        35                  40                  45              


Phe Ala Phe Gln Glu Ala Ile Leu Arg Ala Asp Gly Ser Gly Asn Leu 
    50                  55                  60                  


Arg Val Gly Arg Leu Glu Ile Lys Lys Ser Trp Leu Arg Gln Tyr Ala 
65                  70                  75                  80  


Arg Glu Tyr Phe Tyr Ala Leu Ser Glu Asp Glu Arg Arg Cys Lys Asn 
                85                  90                  95      


Lys Phe Gln Ala Lys Leu Phe Asp Arg Val Leu Ser Asp Trp Leu Glu 
            100                 105                 110         


Arg Asn Asn Glu Leu Leu Gln Arg Leu Asn Asn Ile Leu Ser Leu Pro 
        115                 120                 125             


Gln Glu Ser Lys Thr Gly Ala Ser Asp Leu Ser Leu Leu Val Arg Gln 
    130                 135                 140                 


Leu Lys Gly Ala Glu Tyr Phe Tyr Phe Ile Arg Asp Phe Thr Gln Ser 
145                 150                 155                 160 


Gly Ile Ile Asn Asp Lys Asp Ser Asp Glu His Ile Lys Asn Leu Ala 
                165                 170                 175     


Gly Ile Val Glu Lys Phe Glu Thr Leu Leu Asp Lys Val Leu Phe Leu 
            180                 185                 190         


Thr Ala Pro Asn Ser Ser Gln Gly Val Glu Thr Thr Arg Ala Ser Phe 
        195                 200                 205             


Asn Tyr Tyr Thr Val Asn Lys Ile Ser Lys Asn Phe Asp Glu Asn Ile 
    210                 215                 220                 


Lys Lys Ala Asn Gly Arg Leu Cys Ser Ser Tyr Gln Asn Ser Met Asn 
225                 230                 235                 240 


Glu Glu Leu Leu Arg Lys Val Gly Phe Leu Lys Tyr Leu Lys Asp Glu 
                245                 250                 255     


Tyr Arg Ala Glu Leu Gln Asn Val Ser Leu Lys Asp Leu Tyr Glu Ala 
            260                 265                 270         


Leu Lys Lys Phe Lys Ser Gln Gln Lys Thr Ala Phe Ile Gln Ala Val 
        275                 280                 285             


Gln Lys Asn Lys Ser Glu Lys Glu Leu Met Arg Glu Phe Pro Leu Phe 
    290                 295                 300                 


Asn Gly Lys Gln Pro Asp Thr Leu Gln Lys Phe Ile Leu Glu Thr Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Gly Ala Tyr Phe Gln Lys Trp Gly Phe Asp Asn Tyr 
                325                 330                 335     


Ile Ser Phe Cys Asn Lys Ile Phe Lys Pro Val Ala Met Glu Thr Gly 
            340                 345                 350         


Thr Arg Lys Ala Lys Ile Arg Ala Leu Glu Gln Glu Lys Ile Glu Ala 
        355                 360                 365             


Arg Leu Leu Gln Tyr Trp Ala His Ile Leu Val Lys Asp Gly Lys Tyr 
    370                 375                 380                 


Phe Leu Leu Leu Ile Pro Lys Glu Lys Met Gly Glu Ala Lys Val Phe 
385                 390                 395                 400 


Phe Ala Arg Leu Ser Asp Gln Glu Gly Gly Glu Tyr Thr Leu Tyr Ala 
                405                 410                 415     


Phe Asn Ser Leu Thr Leu Arg Ala Leu Lys Lys Leu Ile Arg Arg Asn 
            420                 425                 430         


Leu Gly Lys Glu Gln Val Arg Leu Ser Ala Gly Asp Ala Asp Ala Ile 
        435                 440                 445             


Ala Leu Cys Gln Glu Val Leu Arg Gly Arg Tyr His Gln Leu Lys Asp 
    450                 455                 460                 


Leu Asp Leu Ser Gly Phe Glu Lys Glu Ile Ala Glu Ile Ala Asn Thr 
465                 470                 475                 480 


Gln Tyr Glu Asn Glu Glu Glu Phe Arg Ile Ala Leu Glu Gln Val Ala 
                485                 490                 495     


Tyr Tyr Leu Ser Glu Arg Lys Met Asn Glu Glu Ser Ile Glu Tyr Leu 
            500                 505                 510         


Lys Lys Asn Leu Gly Ala Ile Leu Leu Glu Ile Ser Ser Tyr Asp Leu 
        515                 520                 525             


Glu Arg Asn Ile Thr Gly Glu Ser Lys Glu His Thr Arg Leu Trp Ser 
    530                 535                 540                 


Asp Phe Trp Asn Pro Asn Asn Lys Lys Glu Cys Phe Ser Thr Arg Leu 
545                 550                 555                 560 


Asn Pro Glu Leu Arg Ile Phe Tyr Arg Pro Pro Arg Glu Gln Lys Asp 
                565                 570                 575     


Pro Lys Lys Gln Lys Asn Arg Phe Ser Lys Asp His Leu Ala Val Ala 
            580                 585                 590         


Phe Thr Ile Ala Gln Asn Ala Ala Arg Lys Arg Met Glu Thr Ser Phe 
        595                 600                 605             


Ala Glu Glu Lys Asp Leu Val Glu Gln Val Lys Lys Phe Asn Glu Glu 
    610                 615                 620                 


Val Val Gly Lys Phe Ile Asp Glu Lys Ser Asp Asn Leu Tyr Tyr Tyr 
625                 630                 635                 640 


Gly Ile Asp Arg Gly Gln Gln Glu Leu Ala Thr Leu Cys Val Val Arg 
                645                 650                 655     


Phe Ser Lys Glu His Tyr Glu Ala Met Leu Glu Asp Asn Phe Ile Lys 
            660                 665                 670         


Lys Phe Ser Lys Pro Ile Pro Ala Gln Ile Thr Ala Tyr Arg Ile Lys 
        675                 680                 685             


Asp Glu His Met Ser Tyr Arg Lys Asn Ile Thr Arg Asp Leu Lys Gly 
    690                 695                 700                 


Asn Glu Thr Glu Glu Ile Leu Phe Lys Asn Pro Ser His Phe Ile Asp 
705                 710                 715                 720 


Glu Val Glu Asn Phe Glu Glu Val Ser Thr Pro Cys Ile Asp Leu Thr 
                725                 730                 735     


Thr Ala Lys Leu Ile Lys Gly Lys Ile Ile Leu Asn Gly Asp Ile Gln 
            740                 745                 750         


Thr Tyr Leu Ala Leu Lys Lys Ala Asn Gly Lys Arg Gln Leu Phe Glu 
        755                 760                 765             


Lys Phe Ala Lys Ile Asp Asp Ser Ala Lys Ile Glu Phe Asp Asp Ser 
    770                 775                 780                 


Glu Gly Arg Phe Gln Val Lys Ser Lys Ala Thr Glu Arg Glu Glu Tyr 
785                 790                 795                 800 


Gln Phe Leu Pro Tyr Tyr Gly Pro Glu Gln Glu Asn Ile Ser Pro Arg 
                805                 810                 815     


Glu Asp Met Arg Arg Glu Leu Gln Ala Tyr Leu Asp Lys Leu Arg Ser 
            820                 825                 830         


Ser Glu Ser Phe Glu Glu Asp Ile Ser Ile Glu Lys Ile Asn His Leu 
        835                 840                 845             


Arg Asp Ala Ile Thr Ser Asn Met Val Gly Ile Ile Ala Phe Leu Phe 
    850                 855                 860                 


Thr Glu Tyr Pro Gly Ile Ile Asn Leu Glu Asn Leu His Ser Arg Glu 
865                 870                 875                 880 


Asn Ile Glu Lys Asn Trp Arg Lys Asn Asn Glu Asp Ile Ser Arg Arg 
                885                 890                 895     


Leu Glu Trp Gly Leu Tyr Lys Lys Phe Gln Lys Ile Gly Leu Val Pro 
            900                 905                 910         


Pro Arg Leu Arg Gln Thr Val Leu Leu Arg Glu Asn Glu Thr Glu Arg 
        915                 920                 925             


Gln Glu Lys Leu Asn Gln Phe Gly Ile Ile His Phe Ile Pro Thr Glu 
    930                 935                 940                 


Lys Thr Ser Ala Arg Cys Pro Tyr Cys Gly Glu Asn Thr Pro Met Lys 
945                 950                 955                 960 


Gln Arg Asn Glu Asp Lys Phe Lys Leu His Ala Tyr Ile Cys Arg Ser 
                965                 970                 975     


Asn Glu Glu Asn Cys Gly Phe Asp Thr Arg Glu Pro Lys Ser Pro Leu 
            980                 985                 990         


Glu Phe Ile Lys Asn Ser Asp Asp  Val Ala Ala Tyr Asn  Ile Ala Lys 
        995                 1000                 1005             


Lys Arg  Leu Ser Arg Ala Asp  Pro Lys Lys Lys Arg  Lys Val 
    1010                 1015                 1020         


<210>  81
<211>  1078
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.2-NLSںϵ׵İ

<400>  81

Met Lys Asn Gly Ile Asn Leu Phe Lys Thr Lys Thr Thr Lys Thr Lys 
1               5                   10                  15      


Gly Val Asp Met Glu Lys Tyr Gln Ile Thr Lys Thr Ile Arg Phe Lys 
            20                  25                  30          


Leu Leu Pro Asp Asn Ala His Glu Ile Val Glu Lys Val Lys Ser Leu 
        35                  40                  45              


Lys Thr Ser Asn Val Asp Glu Leu Met Asp Glu Val Lys Asn Val His 
    50                  55                  60                  


Leu Lys Gly Leu Glu Leu Leu Phe Ala Leu Lys Lys Tyr Phe Tyr Phe 
65                  70                  75                  80  


Asp Gly Asn Gln Cys Lys Ser Phe Lys Ser Thr Leu Glu Ile Lys Ala 
                85                  90                  95      


Arg Trp Leu Arg Leu Tyr Thr Pro Asp Gln Tyr Tyr Leu Lys Lys Ser 
            100                 105                 110         


Ser Lys Asn Ser Tyr Gln Leu Lys Ser Leu Ser Tyr Phe Lys Asp Val 
        115                 120                 125             


Phe Asn Asp Trp Leu Phe Asn Trp Glu Glu Ser Val Ser Glu Leu Ala 
    130                 135                 140                 


Ile Ile Tyr Glu Lys Tyr Lys Ile Cys Gln His Gln Arg Asp Ser Arg 
145                 150                 155                 160 


Ala Asp Ile Ala Leu Leu Ile Lys Lys Leu Ser Met Lys Glu Tyr Phe 
                165                 170                 175     


Pro Phe Ile Ser Asp Leu Ile Asp Cys Val Asn Asp Lys Asn Ser Asn 
            180                 185                 190         


Lys Thr Phe Leu Met Lys Leu Ser Glu Glu Leu Ser Val Leu Leu Glu 
        195                 200                 205             


Lys Cys Asn Ser Arg Ala Leu Pro Tyr Gln Ser Asn Gly Ile Val Val 
    210                 215                 220                 


Gly Lys Ala Ser Leu Asn Tyr Tyr Thr Val Ser Lys Ser Glu Lys Met 
225                 230                 235                 240 


Leu Gln Asn Glu Tyr Glu Asp Val Cys Gln Ser Leu Asp Lys Asn Tyr 
                245                 250                 255     


Asp Ile Thr Glu Met Lys Val Ile Leu Tyr Lys Glu Lys Leu Asp Asn 
            260                 265                 270         


Leu Asn Phe Lys Asp Val Thr Ile Ala Asn Ala Tyr Asn Leu Leu Lys 
        275                 280                 285             


Glu Asn Lys Ala Leu Gln Lys Arg Leu Phe Ser Glu Tyr Val Ser Gln 
    290                 295                 300                 


Gly Lys Val Leu Ser Leu Ile Lys Thr Glu Leu Pro Leu Phe Ser Asn 
305                 310                 315                 320 


Ile Asn Asp Asn Asp Phe Glu Lys Tyr Lys Glu Trp Ser Asn Glu Ile 
                325                 330                 335     


Lys Lys Leu Ala Asp Lys Lys Asn Thr Phe Cys Lys Lys Thr Gln Gln 
            340                 345                 350         


Asp Lys Ile Lys Asp Ile Gln Asn Lys Ile Ser Glu Leu Lys Lys Lys 
        355                 360                 365             


Arg Gly Ala Leu Phe Gln Tyr Lys Phe Thr Ser Phe Gln Lys His Cys 
    370                 375                 380                 


Asp Asn Tyr Lys Lys Val Ala Val Gln Tyr Gly Lys Leu Lys Ala Arg 
385                 390                 395                 400 


Lys Lys Ala Ile Glu Lys Asp Glu Ile Glu Ala Asn Leu Leu Arg Tyr 
                405                 410                 415     


Trp Ser Val Ile Leu Glu Gln Glu Asp Lys His Ser Leu Val Leu Ile 
            420                 425                 430         


Pro Lys Asn Asn Ala Lys Asp Ala Lys Gln Tyr Ile Glu Thr Ile Asn 
        435                 440                 445             


Thr Lys Gly Gly Lys Tyr Ile Ile His His Leu Asp Ser Leu Thr Leu 
    450                 455                 460                 


Arg Ala Leu Asn Lys Leu Cys Phe Asn Ala Val Asp Ile Glu Lys Gly 
465                 470                 475                 480 


Gln Met Val Arg Glu Asn Thr Phe Tyr Gln Gly Ile Lys Glu Glu Phe 
                485                 490                 495     


Glu Arg Asn Lys Ile Asn Cys Asp Asn Gln Gly Val Leu Lys Ile Gln 
            500                 505                 510         


Gly Leu Tyr Ser Phe Lys Thr Glu Gly Gly Gln Ile Asn Glu Lys Glu 
        515                 520                 525             


Ala Val Glu Phe Phe Lys Glu Val Leu Lys Ser Asn Tyr Ala Arg Glu 
    530                 535                 540                 


Val Leu Asn Leu Pro Tyr Asp Leu Glu Ser Asn Ile Phe Gln Lys Glu 
545                 550                 555                 560 


Tyr Thr Asn Leu Asp Gln Phe Arg Gln Asp Leu Glu Lys Cys Cys Tyr 
                565                 570                 575     


Ala Leu His Ser Lys Ile Gly Lys Asp Asp Leu Asp Glu Phe Thr Arg 
            580                 585                 590         


Arg Phe Glu Ala Gln Val Phe Asp Ile Thr Ser Ile Asp Leu Lys Ser 
        595                 600                 605             


Lys Lys Glu Lys Thr Lys Thr Thr Gly Glu Met Lys Lys His Thr Gln 
    610                 615                 620                 


Leu Trp Leu Glu Phe Trp Lys Gly Ala Ile Glu Gln Asn Phe Ala Thr 
625                 630                 635                 640 


Arg Val Asn Pro Glu Leu Ser Ile Phe Trp Arg Ala Pro Lys Ser Ser 
                645                 650                 655     


Arg Glu Lys Lys Tyr Gly Lys Gly Ser Asp Leu Tyr Asp Pro Asn Lys 
            660                 665                 670         


Asn Asn Arg Tyr Leu Tyr Glu Gln Tyr Thr Leu Ala Leu Thr Ile Thr 
        675                 680                 685             


Glu Asn Ala Gly Ser His Phe Lys Asp Ile Ala Phe Lys Asp Thr Ser 
    690                 695                 700                 


Lys Ile Lys Glu Ala Ile Lys Glu Phe Asn Met Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Lys Tyr Cys Phe Gly Ile Asp Arg Gly Asn Ala Glu Leu Val Ser Leu 
                725                 730                 735     


Cys Leu Ile Lys Asn Glu Lys Asp Phe Pro Phe Glu Lys Phe Pro Val 
            740                 745                 750         


Tyr Arg Leu Arg Asp Leu Thr Tyr Gln Gly Asp Phe Lys Asp Lys His 
        755                 760                 765             


Asp Gln Met Arg Tyr Gly Val Ala Ile Lys Asn Ile Ser Tyr Phe Ile 
    770                 775                 780                 


Asp Gln Glu Asp Leu Phe Glu Lys Asn Asn Leu Ser Ala Ile Asp Met 
785                 790                 795                 800 


Thr Thr Ala Lys Leu Ile Lys Asn Lys Ile Val Leu Asn Gly Asp Val 
                805                 810                 815     


Leu Thr Tyr Leu Lys Leu Lys Glu Glu Thr Ala Lys His Lys Leu Thr 
            820                 825                 830         


Gln Phe Phe Gln Gly Ser Ser Ile Asn Lys Asn Ser Arg Val Tyr Phe 
        835                 840                 845             


Asp Glu Asp Glu Asn Val Phe Lys Ile Thr Thr Asn Arg Asn His Asn 
    850                 855                 860                 


Pro Glu Glu Ile Ile Tyr Phe Tyr Arg Gly Glu Tyr Gly Ala Ile Lys 
865                 870                 875                 880 


Asn Lys Asn Asp Leu Glu Asp Ile Leu Asn Glu Tyr Leu Cys Lys Met 
                885                 890                 895     


Glu Thr Gly Glu Ser Glu Ile Val Leu Leu Asn Arg Val Asn His Leu 
            900                 905                 910         


Arg Asp Ala Ile Ser Ala Asn Ile Val Gly Ile Leu Ser Tyr Leu Ile 
        915                 920                 925             


Asp Leu Phe Pro Glu Thr Ile Val Ala Leu Glu Asn Leu Ala Lys Gly 
    930                 935                 940                 


Thr Ile Asp Arg His Val Ser Gln Ser Tyr Glu Asn Ile Thr Arg Arg 
945                 950                 955                 960 


Phe Glu Trp Ala Leu Tyr Arg Lys Leu Leu Asn Lys Gln Leu Ala Pro 
                965                 970                 975     


Pro Glu Leu Lys Glu Asn Ile Leu Leu Arg Glu Gly Asp Asp Lys Ile 
            980                 985                 990         


Asp Gln Phe Gly Ile Ile His Phe  Val Glu Glu Lys Asn  Thr Ser Lys 
        995                 1000                 1005             


Asp Cys  Pro Asn Cys Arg Lys  Thr Thr Gln Gln Thr  Asn Asp Asn 
    1010                 1015                 1020             


Lys Phe  Lys Glu Lys Lys Phe  Val Cys Lys Ser Cys  Gly Phe Asp 
    1025                 1030                 1035             


Thr Ser  Lys Asp Arg Lys Gly  Met Asp Ser Leu Asn  Ser Pro Asp 
    1040                 1045                 1050             


Thr Val  Ala Ala Tyr Asn Val  Ala Arg Lys Lys Phe  Glu Ser Ser 
    1055                 1060                 1065             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val 
    1070                 1075             


<210>  82
<211>  1102
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.3-NLSںϵ׵İ

<400>  82

Met Ala Gly Thr Pro Tyr Thr Gly His Val Ala Cys Lys Tyr Cys Lys 
1               5                   10                  15      


Ile Thr Ser Trp Ala Thr Tyr Asp Arg Ile Lys Ile Asn Lys Ile Asn 
            20                  25                  30          


Met Asn Gln Ser Phe Ile Asn Gly Gln Asn Phe Tyr Glu Leu Arg Lys 
        35                  40                  45              


Thr Ile Arg Phe Val Leu Asp Pro Lys Thr Leu Lys Arg Pro Tyr Thr 
    50                  55                  60                  


Pro Ser Ser Asp Glu Val Asn Leu Glu Glu Gln Leu Asn Asn Phe Ile 
65                  70                  75                  80  


Glu Lys Tyr Gln Gln Gly Ile Asn Asp Phe Lys Tyr Ile Val Tyr Phe 
                85                  90                  95      


Gly Pro Lys Thr Ala Glu Thr Lys Glu Leu Asn Lys Lys Ile Ser Ile 
            100                 105                 110         


Lys His Ser Trp Leu Arg Asn Tyr Thr Lys Ser Glu Phe Tyr Ser Ile 
        115                 120                 125             


Lys Asp Lys Leu Ile Gln Leu Asp Tyr Asn Gly Asn Lys Ala Ser Ile 
    130                 135                 140                 


Gly Asn Ser Asn Leu Lys Phe Leu Asn Glu Tyr Phe Glu Asn Trp Ile 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Cys Ala Asp Ala Leu Lys Asn Cys Ile Asn Ala 
                165                 170                 175     


Pro Ala Glu Lys Gln Lys Arg Lys Ser Glu Ala Ala His Trp Val Arg 
            180                 185                 190         


Lys Leu Thr Lys Arg Ser Asn Phe Glu Cys Ile Phe Glu Leu Phe Asn 
        195                 200                 205             


Gly Asn Ile Asp His Lys Asn Ser Asn Asp Asp Ile Glu Lys Ile Lys 
    210                 215                 220                 


His Cys Leu Asn Glu Cys Lys Thr Leu Leu Thr Ser Leu Glu Lys Met 
225                 230                 235                 240 


Leu Leu Pro Ser Gln Ser Leu Gly Met Glu Ile Glu Arg Ala Ser Leu 
                245                 250                 255     


Asn Tyr Tyr Thr Ile Asn Lys Lys Pro Lys Asn Tyr Asp Glu Asp Ile 
            260                 265                 270         


Ala Gln Lys Ala Ser Ala Leu Asn Glu Ala Tyr Gln Phe Lys Ala Asp 
        275                 280                 285             


Asp Lys Ala Phe Leu Asn Arg Val Gly Phe Ser Asp Asp Gly Val Pro 
    290                 295                 300                 


Ile Asn Glu Leu Lys Glu Ala Met Lys Lys Phe Lys Ala Asp Gln Lys 
305                 310                 315                 320 


Ser Lys Phe Tyr Glu Phe Val Asn Gln Lys Lys Ser Tyr Ser Asp Leu 
                325                 330                 335     


Lys Lys Asn Asp Asp Leu Lys Leu Leu Asn Asp Ile Ser Glu Glu Asp 
            340                 345                 350         


Phe Asn Lys Phe Lys Glu Thr Gln Asp Lys Met Thr Arg Gly Lys His 
        355                 360                 365             


Phe Gln Phe Ser Phe Pro Asn Tyr Lys Lys Ser Glu Lys Asn Phe Cys 
    370                 375                 380                 


Asp Leu Tyr Lys Asn Val Ala Val Ala Phe Gly Lys Ile Arg Ala Asp 
385                 390                 395                 400 


Ile Lys Ala Leu Glu Lys Glu Arg Met Asp Ala Glu Lys Leu Gln Cys 
                405                 410                 415     


Trp Ala Val Ile Leu Glu Lys Asp Asn Gln Arg Tyr Val Val Thr Ile 
            420                 425                 430         


Pro Arg Asp Ala Asn Asn Asn Leu Thr Asn Thr Lys Gln Tyr Ile Asp 
        435                 440                 445             


Asn Leu Gln Asn Glu Glu Asn Asp Gln Trp Ile Leu Tyr Ala Phe Glu 
    450                 455                 460                 


Ser Leu Thr Leu Arg Ser Leu Asp Lys Leu Cys Phe Gly Leu Asp Lys 
465                 470                 475                 480 


Asn Thr Phe Ile Pro Ala Ile Thr Gly Glu Leu Tyr Gln Lys Asn Asn 
                485                 490                 495     


Ser Phe Phe Glu Lys Gly Leu Leu Lys Arg Lys Asp Gln Phe Ser Gln 
            500                 505                 510         


Asn Gly Thr Asp Leu Ala Ala Phe Tyr Lys Thr Val Leu Glu Leu Asp 
        515                 520                 525             


Ser Thr Lys Lys Met Leu Gly Ile Asn Lys Tyr Ala Asp Phe Lys Ala 
    530                 535                 540                 


Phe Ile Ser Lys Glu Tyr Thr Ala Leu Glu Asp Phe Glu Lys Thr Leu 
545                 550                 555                 560 


Lys Glu Thr Cys Tyr Phe Lys Lys Arg Val Phe Ile Ser Glu Asp Thr 
                565                 570                 575     


Lys Asn Lys Leu Ile Asn Asp Tyr Gln Gly Asn Leu Tyr Lys Ile Thr 
            580                 585                 590         


Ser Tyr Asp Leu Glu Lys Asp Asp Ser Glu Ala Leu Gly Thr Leu Ile 
        595                 600                 605             


Asn Lys Lys Gln Phe Asn Arg Ala Ser Pro Glu Ile His Thr Lys Thr 
    610                 615                 620                 


Trp Leu Asp Phe Trp Thr Ala Asp Asn Glu Thr Asp Lys Tyr Pro Ile 
625                 630                 635                 640 


Arg Leu Asn Pro Glu Phe Lys Ile Ser Phe Val Glu Lys Gln Asp Lys 
                645                 650                 655     


Asp Leu Asn Met Arg Asn Leu Gly Leu Leu Asn Lys Asn Arg Arg Leu 
            660                 665                 670         


Lys Ser Gln Phe Leu Leu Ser Thr Thr Ile Thr Leu Leu Ala His Glu 
        675                 680                 685             


Lys Asn Ala Asp Leu His Phe Lys Lys Thr Asp Glu Ile Gln Thr Phe 
    690                 695                 700                 


Ile Asn Ser Tyr Asn Gln Glu Phe Asn Lys Lys Ile Lys Pro Phe Asp 
705                 710                 715                 720 


Ile Tyr Tyr Tyr Gly Leu Asp Arg Gly Gln Lys Glu Leu Leu Thr Leu 
                725                 730                 735     


Gly Leu Phe Lys Phe Ser Glu Asn Glu Lys Val Ser Phe Thr Lys Gln 
            740                 745                 750         


Asp Gly Thr Val Gly Glu Tyr Ser Lys Pro Lys Phe Ile Pro Leu Asp 
        755                 760                 765             


Val Tyr Gln Ile Arg Glu Gly Gln Tyr Leu Thr Lys Asn Lys Lys Gly 
    770                 775                 780                 


Arg Leu Ala Tyr Lys Ser Ile Asp Gln Phe Ile Asp Asp Glu Lys Val 
785                 790                 795                 800 


Ile Glu Lys Leu Pro Val Asn Ser Cys Leu Asp Leu Ser Cys Ala Lys 
                805                 810                 815     


Leu Val Lys Gly Lys Ile Ile Gln Asn Gly Asp Val Ala Thr Tyr Leu 
            820                 825                 830         


Glu Leu Lys Arg Val Ser Ala Leu Arg Lys Ile Tyr Glu Asn Thr Thr 
        835                 840                 845             


Arg Gly Gln Phe Lys Thr Asp Arg Ile Gly Phe Asn Lys Asp Lys Gly 
    850                 855                 860                 


Cys Leu Phe Leu Asp Ile Glu Asn Arg Gly Lys Leu Glu Asn Asn Asn 
865                 870                 875                 880 


Leu Tyr Phe Tyr Asp Asn Arg Phe Ala Glu Ile Leu Ser Leu Asp Ser 
                885                 890                 895     


Ile Ile Lys Glu Leu Gln Asp Tyr Tyr Asn Glu Val Lys Asn Lys Gln 
            900                 905                 910         


Asn Ile Glu Phe Ile Ser Ile Asp Lys Ile Asn His Leu Arg Asp Ala 
        915                 920                 925             


Leu Cys Ala Asn Ala Val Gly Ile Leu Ala His Leu Gln Lys Thr His 
    930                 935                 940                 


Phe Gly Val Ile Val Phe Glu Gly Leu Asp Ala Arg His Lys Asn Lys 
945                 950                 955                 960 


Glu Thr Thr Glu Phe Ala Gly Asn Leu Ala Ser Arg Ile Glu Arg Lys 
                965                 970                 975     


Ile Leu Gln Lys Leu Glu Thr Leu Ser Leu Ile Pro Pro Gln His Arg 
            980                 985                 990         


Gln Ile Ile Asp Leu Gln Asn Ser  Lys Gln Ile Lys Gln  Thr Gly Ala 
        995                 1000                 1005             


Val Leu  Tyr Ile Glu Glu Lys  Gly Thr Ser Ala Asn  Cys Pro His 
    1010                 1015                 1020             


Cys Glu  Thr Ala Asn Pro Asp  Lys Ser Glu Lys Trp  Leu Ala His 
    1025                 1030                 1035             


Asn Tyr  Lys Cys Lys Asn Ser  Asn Cys Asn Phe Asp  Ala Ser Glu 
    1040                 1045                 1050             


Ile Ser  Lys Arg Lys Asp Leu  Ile Gly Leu Asp Asn  Ser Asp Ser 
    1055                 1060                 1065             


Val Ala  Thr Tyr Asn Ile Ala  Lys Arg Gly Leu Leu  Glu Met Asn 
    1070                 1075                 1080             


Gln Lys  Ile Glu Gln Ser Lys  Val Ser Arg Ala Asp  Pro Lys Lys 
    1085                 1090                 1095             


Lys Arg  Lys Val 
    1100         


<210>  83
<211>  1068
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.4-NLSںϵ׵İ

<400>  83

Met Glu Ile Gln Glu Leu Lys Asn Leu Tyr Glu Val Lys Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ser Lys Lys Lys Ile Phe Glu Gly Gly Asp 
            20                  25                  30          


Val Ile Lys Leu Gln Lys Asp Phe Glu Lys Val Gln Lys Phe Phe Leu 
        35                  40                  45              


Asp Ile Phe Val Tyr Lys Asn Glu His Thr Lys Leu Glu Phe Lys Lys 
    50                  55                  60                  


Lys Arg Glu Ile Lys Tyr Thr Trp Leu Arg Thr Asn Thr Lys Asn Glu 
65                  70                  75                  80  


Phe Tyr Asn Trp Arg Gly Lys Ser Asp Thr Gly Lys Asn Tyr Ala Leu 
                85                  90                  95      


Asn Lys Ile Gly Phe Leu Ala Glu Glu Ile Leu Arg Trp Leu Asn Glu 
            100                 105                 110         


Trp Gln Glu Leu Thr Lys Ser Leu Lys Asp Leu Thr Gln Arg Glu Glu 
        115                 120                 125             


His Lys Gln Glu Arg Lys Ser Asp Ile Ala Phe Val Leu Arg Asn Phe 
    130                 135                 140                 


Leu Lys Arg Gln Asn Leu Pro Phe Ile Lys Asp Phe Phe Asn Ala Val 
145                 150                 155                 160 


Ile Asp Ile Gln Gly Lys Gln Gly Lys Glu Ser Asp Asp Lys Ile Arg 
                165                 170                 175     


Lys Phe Arg Glu Glu Ile Lys Glu Ile Glu Lys Asn Leu Asn Ala Cys 
            180                 185                 190         


Ser Arg Glu Tyr Leu Pro Thr Gln Ser Asn Gly Val Leu Leu Tyr Lys 
        195                 200                 205             


Ala Ser Phe Ser Tyr Tyr Thr Leu Asn Lys Thr Pro Lys Glu Tyr Glu 
    210                 215                 220                 


Asp Leu Lys Lys Glu Lys Glu Ser Glu Leu Ser Ser Val Leu Leu Lys 
225                 230                 235                 240 


Glu Ile Tyr Arg Arg Lys Arg Phe Asn Arg Thr Thr Asn Gln Lys Asp 
                245                 250                 255     


Thr Leu Phe Glu Cys Thr Ser Asp Trp Leu Val Lys Ile Lys Leu Gly 
            260                 265                 270         


Lys Asp Ile Tyr Glu Trp Thr Leu Asp Glu Ala Tyr Gln Lys Met Lys 
        275                 280                 285             


Ile Trp Lys Ala Asn Gln Lys Ser Asn Phe Ile Glu Ala Val Ala Gly 
    290                 295                 300                 


Asp Lys Leu Thr His Gln Asn Phe Arg Lys Gln Phe Pro Leu Phe Asp 
305                 310                 315                 320 


Ala Ser Asp Glu Asp Phe Glu Thr Phe Tyr Arg Leu Thr Lys Ala Leu 
                325                 330                 335     


Asp Lys Asn Pro Glu Asn Ala Lys Lys Ile Ala Gln Lys Arg Gly Lys 
            340                 345                 350         


Phe Phe Asn Ala Pro Asn Glu Thr Val Gln Thr Lys Asn Tyr His Glu 
        355                 360                 365             


Leu Cys Glu Leu Tyr Lys Arg Ile Ala Val Lys Arg Gly Lys Ile Ile 
    370                 375                 380                 


Ala Glu Ile Lys Gly Ile Glu Asn Glu Glu Val Gln Ser Gln Leu Leu 
385                 390                 395                 400 


Thr His Trp Ala Val Ile Ala Glu Glu Arg Asp Lys Lys Phe Ile Val 
                405                 410                 415     


Leu Ile Pro Arg Lys Asn Gly Gly Lys Leu Glu Asn His Lys Asn Ala 
            420                 425                 430         


His Ala Phe Leu Gln Glu Lys Asp Arg Lys Glu Pro Asn Asp Ile Lys 
        435                 440                 445             


Val Tyr His Phe Lys Ser Leu Thr Leu Arg Ser Leu Glu Lys Leu Cys 
    450                 455                 460                 


Phe Lys Glu Ala Lys Asn Thr Phe Ala Pro Glu Ile Lys Lys Glu Thr 
465                 470                 475                 480 


Asn Pro Lys Ile Trp Phe Pro Thr Tyr Lys Gln Glu Trp Asn Ser Thr 
                485                 490                 495     


Pro Glu Arg Leu Ile Lys Phe Tyr Lys Gln Val Leu Gln Ser Asn Tyr 
            500                 505                 510         


Ala Gln Thr Tyr Leu Asp Leu Val Asp Phe Gly Asn Leu Asn Thr Phe 
        515                 520                 525             


Leu Glu Thr His Phe Thr Thr Leu Glu Glu Phe Glu Ser Asp Leu Glu 
    530                 535                 540                 


Lys Thr Cys Tyr Thr Lys Val Pro Val Tyr Phe Ala Lys Lys Glu Leu 
545                 550                 555                 560 


Glu Thr Phe Ala Asp Glu Phe Glu Ala Glu Val Phe Glu Ile Thr Thr 
                565                 570                 575     


Arg Ser Ile Ser Thr Glu Ser Lys Arg Lys Glu Asn Ala His Ala Glu 
            580                 585                 590         


Ile Trp Arg Asp Phe Trp Ser Arg Glu Asn Glu Glu Glu Asn His Ile 
        595                 600                 605             


Thr Arg Leu Asn Pro Glu Val Ser Val Leu Tyr Arg Asp Glu Ile Lys 
    610                 615                 620                 


Glu Lys Ser Asn Thr Ser Arg Lys Asn Arg Lys Ser Asn Ala Asn Asn 
625                 630                 635                 640 


Arg Phe Ser Asp Pro Arg Phe Thr Leu Ala Thr Thr Ile Thr Leu Asn 
                645                 650                 655     


Ala Asp Lys Lys Lys Ser Asn Leu Ala Phe Lys Thr Val Glu Asp Ile 
            660                 665                 670         


Asn Ile His Ile Asp Asn Phe Asn Lys Lys Phe Ser Lys Asn Phe Ser 
        675                 680                 685             


Gly Glu Trp Val Tyr Gly Ile Asp Arg Gly Leu Lys Glu Leu Ala Thr 
    690                 695                 700                 


Leu Asn Val Val Lys Phe Ser Asp Val Lys Asn Val Phe Gly Val Ser 
705                 710                 715                 720 


Gln Pro Lys Glu Phe Ala Lys Ile Pro Ile Tyr Lys Leu Arg Asp Glu 
                725                 730                 735     


Lys Ala Ile Leu Lys Asp Glu Asn Gly Leu Ser Leu Lys Asn Ala Lys 
            740                 745                 750         


Gly Glu Ala Arg Lys Val Ile Asp Asn Ile Ser Asp Val Leu Glu Glu 
        755                 760                 765             


Gly Lys Glu Pro Asp Ser Thr Leu Phe Glu Lys Arg Glu Val Ser Ser 
    770                 775                 780                 


Ile Asp Leu Thr Arg Ala Lys Leu Ile Lys Gly His Ile Ile Ser Asn 
785                 790                 795                 800 


Gly Asp Gln Lys Thr Tyr Leu Lys Leu Lys Glu Thr Ser Ala Lys Arg 
                805                 810                 815     


Arg Ile Phe Glu Leu Phe Ser Thr Ala Lys Ile Asp Lys Ser Ser Gln 
            820                 825                 830         


Phe His Val Arg Lys Thr Ile Glu Leu Ser Gly Thr Lys Ile Tyr Trp 
        835                 840                 845             


Leu Cys Glu Trp Gln Arg Gln Asp Ser Trp Arg Thr Glu Lys Val Ser 
    850                 855                 860                 


Leu Arg Asn Thr Leu Lys Gly Tyr Leu Gln Asn Leu Asp Leu Lys Asn 
865                 870                 875                 880 


Arg Phe Glu Asn Ile Glu Thr Ile Glu Lys Ile Asn His Leu Arg Asp 
                885                 890                 895     


Ala Ile Thr Ala Asn Met Val Gly Ile Leu Ser His Leu Gln Asn Lys 
            900                 905                 910         


Leu Glu Met Gln Gly Val Ile Ala Leu Glu Asn Leu Asp Thr Val Arg 
        915                 920                 925             


Glu Gln Ser Asn Lys Lys Met Ile Asp Glu His Phe Glu Gln Ser Asn 
    930                 935                 940                 


Glu His Val Ser Arg Arg Leu Glu Trp Ala Leu Tyr Cys Lys Phe Ala 
945                 950                 955                 960 


Asn Thr Gly Glu Val Pro Pro Gln Ile Lys Glu Ser Ile Phe Leu Arg 
                965                 970                 975     


Asp Glu Phe Lys Val Cys Gln Ile Gly Ile Leu Asn Phe Ile Asp Val 
            980                 985                 990         


Lys Gly Thr Ser Ser Asn Cys Pro  Asn Cys Asp Gln Glu  Ser Arg Lys 
        995                 1000                 1005             


Thr Gly  Ser His Phe Ile Cys  Asn Phe Gln Asn Asn  Cys Ile Phe 
    1010                 1015                 1020             


Ser Ser  Lys Glu Asn Arg Asn  Leu Leu Glu Gln Asn  Leu His Asn 
    1025                 1030                 1035             


Ser Asp  Asp Val Ala Ala Phe  Asn Ile Ala Lys Arg  Gly Leu Glu 
    1040                 1045                 1050             


Ile Val  Lys Val Ser Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val 
    1055                 1060                 1065             


<210>  84
<211>  1169
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.5-NLSںϵ׵İ

<400>  84

Met Glu Asn Phe Lys Asn Leu Tyr Glu Val Arg Lys Thr Val Arg Phe 
1               5                   10                  15      


Glu Leu Lys Pro Ser Arg Lys Lys Thr Phe Ala Gly Gly Asp Ile Phe 
            20                  25                  30          


Glu Leu Gln Lys Asp Phe Glu Glu Val Gln Lys Phe Phe Leu Asp Ile 
        35                  40                  45              


Phe Val Phe Ala Ile Glu Gln Glu Lys Leu Tyr Gln Glu Glu Glu Glu 
    50                  55                  60                  


Glu Gly Lys Leu Ser Arg Tyr Thr Lys Ile Glu Phe Lys Lys Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Tyr Thr Trp Leu Arg Ile Tyr Thr Lys Asn Glu Phe Tyr 
                85                  90                  95      


Asp Trp Asn Gly Lys Asn Asp Lys Glu Lys Asn Tyr Ala Leu Ser Lys 
            100                 105                 110         


Ile Asp Phe Leu Glu Lys Glu Ile Leu Arg Trp Phe Asn Glu Trp Gln 
        115                 120                 125             


Glu Leu Thr Val Asn Leu Lys Asn Leu Thr Gln Thr Lys Glu His Glu 
    130                 135                 140                 


Lys Glu Arg Lys Ser Asp Ile Ala Phe Val Leu Arg Asn Phe Leu Lys 
145                 150                 155                 160 


Arg Gln Asn Phe Pro Phe Ile Lys Asp Phe Phe Asn Ala Val Ile Asp 
                165                 170                 175     


Ile Gln Glu Lys Gln Gly Asn Glu Ser Asp Glu Lys Ile Arg Lys Phe 
            180                 185                 190         


Arg Glu Glu Leu Arg Glu Met Lys Lys Asn Leu Asn Thr Cys Ala Lys 
        195                 200                 205             


Glu Tyr Leu Ser Ser Gln Ser Lys Gly Val Leu Leu His Lys Ala Ser 
    210                 215                 220                 


Phe Asn Tyr Tyr Thr Leu Asn Lys Thr Pro Lys Glu Tyr Glu Asn Leu 
225                 230                 235                 240 


Lys Leu Gln Lys Glu Leu Glu Ile Asp Asn Ile Leu Pro Lys Lys Ile 
                245                 250                 255     


Cys Lys Arg Val Arg Trp Asn Lys Glu Lys Lys Gln Glu Asp Ile Leu 
            260                 265                 270         


Phe Glu Cys Asn Ser Asp Trp Leu Val Glu Ile Lys Leu Gly Tyr Asp 
        275                 280                 285             


Ile Gln Lys Trp Thr Leu Asp Glu Ala Tyr Gln Lys Met Lys Thr Trp 
    290                 295                 300                 


Lys Ala Asp Gln Lys Ser Asp Phe Asn Glu Lys Ile Gly Asn Phe Ile 
305                 310                 315                 320 


Asp Gln Tyr Leu Lys Lys Gly Phe Ile Glu Asp Leu Met Asn Glu Asn 
                325                 330                 335     


Glu Lys Lys Asn Ala Glu Ala Ile Leu Arg Glu Phe Ser Val Phe Lys 
            340                 345                 350         


Pro Ile Glu Asn Phe Tyr Phe Tyr Asp Phe Leu Glu Arg Thr Lys Glu 
        355                 360                 365             


Ile Lys Ile Leu Ser Asn Gln Lys Asn Asn Ile Leu Gln Lys Tyr Asn 
    370                 375                 380                 


Lys Asn Ala Lys Tyr Phe Glu Lys Ile Ile Thr Tyr Lys Ile Lys Asp 
385                 390                 395                 400 


Lys Glu Asp Leu Thr Glu Asp Glu Lys Glu Tyr Gln Glu Leu Glu Lys 
                405                 410                 415     


Ser Ile Glu Lys Lys Ala Lys Glu Arg Gly Lys Phe Phe Asn Ala Pro 
            420                 425                 430         


Lys Glu Lys Val Gln Thr Gln His Tyr Phe Glu Leu Cys Glu Leu Tyr 
        435                 440                 445             


Lys Arg Ile Ala Met Lys Arg Gly Lys Ile Ile Ala Glu Ile Lys Gly 
    450                 455                 460                 


Ile Glu Asn Glu Glu Val Gln Ser Gln Leu Leu Thr His Trp Ala Leu 
465                 470                 475                 480 


Ile Ala Glu Glu Gly Glu Lys Lys Ser Val Val Phe Ile Pro Arg Lys 
                485                 490                 495     


Asn Gly Glu Glu Leu Glu Asn His Lys Lys Ala His Glu Phe Leu Gln 
            500                 505                 510         


Lys Gln Glu Lys Lys Glu Phe Gly Asp Ile Lys Ser Tyr His Phe Lys 
        515                 520                 525             


Ser Leu Thr Leu Arg Ala Leu Glu Lys Leu Cys Phe Lys Glu Thr Glu 
    530                 535                 540                 


Asn Thr Phe Thr Pro Glu Ile Lys Lys Glu Thr Asn Pro Lys Val Trp 
545                 550                 555                 560 


Phe Pro Lys Tyr Lys Gln Glu Trp Asn Asp Glu Pro Gln Lys Leu Ile 
                565                 570                 575     


Asn Phe Tyr Lys Gln Val Leu Gln Ser Lys Tyr Ser Gln Lys Tyr Leu 
            580                 585                 590         


Asp Leu Val Ala Phe Gly Asp Leu Lys Ser Phe Leu Glu Thr Ser Phe 
        595                 600                 605             


Asp Asp Leu Gln Ile Phe Glu Ser Gly Leu Glu Lys Thr Cys Tyr Ile 
    610                 615                 620                 


Lys Val Pro Ile Tyr Phe Ser Lys Glu Gly Phe Glu Thr Phe Thr Asn 
625                 630                 635                 640 


Arg Phe Asp Ala Glu Val Phe Glu Ile Thr Thr Arg Ser Ile Ser Ser 
                645                 650                 655     


Glu Ser Lys Arg Lys Glu Asn Ala His Ala Glu Ile Trp Lys Asp Phe 
            660                 665                 670         


Trp Ser Lys Glu Asn Glu Glu Lys Asn His Ile Thr Arg Leu Asn Pro 
        675                 680                 685             


Glu Val Ser Val Phe Tyr Arg Asp Glu Ile Glu Lys Lys Ser Asn Ala 
    690                 695                 700                 


Leu Arg Gly Asn Asn Lys Ser Asn Ile Asn Asn Arg Phe Ser Ala Ser 
705                 710                 715                 720 


Arg Phe Thr Leu Val Thr Thr Ile Thr Ile Arg Ala Thr His Lys Lys 
                725                 730                 735     


Ser Asn Leu Ala Phe Lys Thr Glu Glu Asp Ile Lys Ser His Ile Asp 
            740                 745                 750         


Lys Phe Asn Glu Ala Phe Gln Asn Phe Ser Gly Glu Trp Val Tyr Gly 
        755                 760                 765             


Ile Asp Arg Gly Leu Lys Glu Leu Ala Thr Leu Asn Val Val Lys Phe 
    770                 775                 780                 


Ser Asp Glu Lys Asn Glu Phe Gly Val Ile Lys Pro Lys Glu Phe Ala 
785                 790                 795                 800 


Lys Ile Pro Val Tyr Lys Leu Lys Asp Glu Lys Ala Ile Leu Lys Asp 
                805                 810                 815     


Glu Asn Gly Lys Asp Leu Lys Asn Ala Lys Gly Glu Ala Arg Lys Val 
            820                 825                 830         


Ile Asp Asn Ile Ser Glu Val Leu Glu Glu Lys Lys Glu Pro Asp Ser 
        835                 840                 845             


Asn Leu Phe Glu Lys Gln Gly Val Leu Ser Gln Gly Ile Ser Cys Ile 
    850                 855                 860                 


Asp Leu Thr Gln Ala Lys Leu Ile Lys Gly His Ile Ile Leu Asn Gly 
865                 870                 875                 880 


Asp Gln Lys Thr Tyr Leu Lys Leu Lys Glu Ile Ser Ala Lys Arg Arg 
                885                 890                 895     


Ile Phe Glu Leu Phe Ser Thr Ser Lys Ile Asp Lys Asn Ser Glu Leu 
            900                 905                 910         


Arg Val Glu Lys Thr Thr Ile Ser Ile Asn Ser Glu Asp Gly Lys Arg 
        915                 920                 925             


Asp Phe Tyr Trp Leu Thr Lys Asn Gln Ile Val Asn Ser Glu Thr Lys 
    930                 935                 940                 


Lys Glu Ile Gln Lys Glu Gln Gln Glu Lys Leu Asp Asn Leu Lys Val 
945                 950                 955                 960 


Ile Phe Ile Asp Tyr Leu Glu Gly Leu Cys Val Lys Asn Lys Phe Glu 
                965                 970                 975     


Asp Ile Glu Thr Ile Glu Lys Ile Asn His Leu Arg Asp Ala Ile Thr 
            980                 985                 990         


Ala Asn Met Val Gly Ile Leu Phe  His Leu Gln Lys Glu  Phe Lys Gly 
        995                 1000                 1005             


Ile Ile  Ala Leu Glu Asn Leu  Asp Thr Val Arg Glu  Gln Ser Asn 
    1010                 1015                 1020             


Lys Lys  Met Ile Asp Glu His  Phe Glu Gln Ser Asn  Glu Asp Ile 
    1025                 1030                 1035             


Ser Arg  Arg Leu Glu Trp Ala  Leu Tyr Arg Lys Phe  Ala Asn Met 
    1040                 1045                 1050             


Gly Glu  Val Pro Ser Gln Ile  Lys Glu Ser Ile Phe  Leu Arg Asp 
    1055                 1060                 1065             


Glu Phe  Lys Val Tyr Gln Met  Gly Leu Leu Lys Phe  Val Glu Val 
    1070                 1075                 1080             


Ser Gly  Thr Ser Ser Asn Cys  Pro Asn Cys Asp Lys  Glu Val Gly 
    1085                 1090                 1095             


Lys Thr  Asn Ser His Phe Val  Cys Lys Gly Glu Asn  Asn Cys Gly 
    1100                 1105                 1110             


Phe Ser  Ser Lys Glu Asn Arg  Asn Leu Leu Glu Gln  Asn Leu Asn 
    1115                 1120                 1125             


Asn Ser  Asp Glu Val Ala Ala  Tyr Asn Ile Ala Lys  Arg Gly Leu 
    1130                 1135                 1140             


Lys Leu  Ile Asn Gln Lys Trp  Asn Asn Thr Ser Lys  Ser Gln Asn 
    1145                 1150                 1155             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1160                 1165                 


<210>  85
<211>  1075
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.6-NLSںϵ׵İ

<400>  85

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Leu Pro 
1               5                   10                  15      


Asp Lys Ile Gln Asp Ile Ser Arg Gln Val Ala Val Leu Gln Asn Ser 
            20                  25                  30          


Thr Asn Ala Glu Lys Lys Asn Asn Leu Leu Arg Leu Val Gln Arg Gly 
        35                  40                  45              


Gln Glu Leu Pro Lys Leu Leu Asn Glu Tyr Ile Arg Tyr Ser Asp Asn 
    50                  55                  60                  


His Lys Leu Lys Ser Asn Val Thr Val His Phe Arg Trp Leu Arg Leu 
65                  70                  75                  80  


Phe Thr Lys Asp Leu Phe Tyr Asn Trp Lys Lys Asp Asn Thr Glu Lys 
                85                  90                  95      


Lys Ile Lys Ile Ser Asp Val Val Tyr Leu Ser His Val Phe Glu Ala 
            100                 105                 110         


Phe Leu Lys Glu Trp Glu Ser Thr Ile Glu Arg Val Asn Ala Asp Cys 
        115                 120                 125             


Asn Lys Pro Glu Glu Ser Lys Thr Arg Asp Ala Glu Ile Ala Leu Ser 
    130                 135                 140                 


Ile Arg Lys Leu Gly Ile Lys His Gln Leu Pro Phe Ile Lys Gly Phe 
145                 150                 155                 160 


Val Asp Asn Ser Asn Asp Lys Asn Ser Glu Asp Thr Lys Ser Lys Leu 
                165                 170                 175     


Thr Ala Leu Leu Ser Glu Phe Glu Ala Val Leu Lys Ile Cys Glu Gln 
            180                 185                 190         


Asn Tyr Leu Pro Ser Gln Ser Ser Gly Ile Ala Ile Ala Lys Ala Ser 
        195                 200                 205             


Phe Asn Tyr Tyr Thr Ile Asn Lys Lys Gln Lys Asp Phe Glu Ala Glu 
    210                 215                 220                 


Ile Val Ala Leu Lys Lys Gln Leu His Ala Arg Tyr Gly Asn Lys Lys 
225                 230                 235                 240 


Tyr Asp Gln Leu Leu Arg Glu Leu Asn Leu Ile Pro Leu Lys Glu Leu 
                245                 250                 255     


Pro Leu Lys Glu Leu Pro Leu Ile Glu Phe Tyr Ser Glu Ile Lys Lys 
            260                 265                 270         


Arg Lys Ser Thr Lys Lys Ser Glu Phe Leu Glu Ala Val Ser Asn Gly 
        275                 280                 285             


Leu Val Phe Asp Asp Leu Lys Ser Lys Phe Pro Leu Phe Gln Thr Glu 
    290                 295                 300                 


Ser Asn Lys Tyr Asp Glu Tyr Leu Lys Leu Ser Asn Lys Ile Thr Gln 
305                 310                 315                 320 


Lys Ser Thr Ala Lys Ser Leu Leu Ser Lys Asp Ser Pro Glu Ala Gln 
                325                 330                 335     


Lys Leu Gln Thr Glu Ile Thr Lys Leu Lys Lys Asn Arg Gly Glu Tyr 
            340                 345                 350         


Phe Lys Lys Ala Phe Gly Lys Tyr Val Gln Leu Cys Glu Leu Tyr Lys 
        355                 360                 365             


Glu Ile Ala Gly Lys Arg Gly Lys Leu Lys Gly Gln Ile Lys Gly Ile 
    370                 375                 380                 


Glu Asn Glu Arg Ile Asp Ser Gln Arg Leu Gln Tyr Trp Ala Leu Val 
385                 390                 395                 400 


Leu Glu Asp Asn Leu Lys His Ser Leu Ile Leu Ile Pro Lys Glu Lys 
                405                 410                 415     


Thr Asn Glu Leu Tyr Arg Lys Val Trp Gly Ala Lys Asp Asp Gly Ala 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Thr Leu Tyr Tyr Phe Glu Ser Met Thr Tyr 
        435                 440                 445             


Arg Ala Leu Arg Lys Leu Cys Phe Gly Ile Asn Gly Asn Thr Phe Leu 
    450                 455                 460                 


Pro Glu Ile Gln Lys Glu Leu Pro Gln Tyr Asn Gln Lys Glu Phe Gly 
465                 470                 475                 480 


Glu Phe Cys Phe His Lys Ser Asn Asp Asp Lys Glu Ile Asp Glu Pro 
                485                 490                 495     


Lys Leu Ile Ser Phe Tyr Gln Ser Val Leu Lys Thr Asp Phe Val Lys 
            500                 505                 510         


Asn Thr Leu Ala Leu Pro Gln Ser Val Phe Asn Glu Val Ala Ile Gln 
        515                 520                 525             


Ser Phe Glu Thr Arg Gln Asp Phe Gln Ile Ala Leu Glu Lys Cys Cys 
    530                 535                 540                 


Tyr Ala Lys Lys Gln Ile Ile Ser Glu Ser Leu Lys Lys Glu Ile Leu 
545                 550                 555                 560 


Glu Asn Tyr Asn Thr Gln Ile Phe Lys Ile Thr Ser Leu Asp Leu Gln 
                565                 570                 575     


Arg Ser Glu Gln Lys Asn Leu Lys Gly His Thr Arg Ile Trp Asn Arg 
            580                 585                 590         


Phe Trp Thr Lys Gln Asn Glu Glu Ile Asn Tyr Asn Leu Arg Leu Asn 
        595                 600                 605             


Pro Glu Ile Ala Ile Val Trp Arg Lys Ala Lys Lys Thr Arg Ile Glu 
    610                 615                 620                 


Lys Tyr Gly Glu Arg Ser Val Leu Tyr Glu Pro Glu Lys Arg Asn Arg 
625                 630                 635                 640 


Tyr Leu His Glu Gln Tyr Thr Leu Cys Thr Thr Val Thr Asp Asn Ala 
                645                 650                 655     


Leu Asn Asn Glu Ile Thr Phe Ala Phe Glu Asp Thr Lys Lys Lys Gly 
            660                 665                 670         


Thr Glu Ile Val Lys Tyr Asn Glu Lys Ile Asn Gln Thr Leu Lys Lys 
        675                 680                 685             


Glu Phe Asn Lys Asn Gln Leu Trp Phe Tyr Gly Ile Asp Ala Gly Glu 
    690                 695                 700                 


Ile Glu Leu Ala Thr Leu Ala Leu Met Asn Lys Asp Lys Glu Pro Gln 
705                 710                 715                 720 


Leu Phe Thr Val Tyr Glu Leu Lys Lys Leu Asp Phe Phe Lys His Gly 
                725                 730                 735     


Tyr Ile Tyr Asn Lys Glu Arg Glu Leu Val Ile Arg Glu Lys Pro Tyr 
            740                 745                 750         


Lys Ala Ile Gln Asn Leu Ser Tyr Phe Leu Asn Glu Glu Leu Tyr Glu 
        755                 760                 765             


Lys Thr Phe Arg Asp Gly Lys Phe Asn Glu Thr Tyr Asn Glu Leu Phe 
    770                 775                 780                 


Lys Glu Lys His Val Ser Ala Ile Asp Leu Thr Thr Ala Lys Val Ile 
785                 790                 795                 800 


Asn Gly Lys Ile Ile Leu Asn Gly Asp Met Ile Thr Phe Leu Asn Leu 
                805                 810                 815     


Arg Ile Leu His Ala Gln Arg Lys Ile Tyr Glu Glu Leu Ile Glu Asn 
            820                 825                 830         


Pro His Ala Glu Leu Lys Glu Lys Asp Tyr Lys Leu Tyr Phe Glu Ile 
        835                 840                 845             


Glu Gly Lys Asp Lys Asp Ile Tyr Ile Ser Arg Leu Asp Phe Glu Tyr 
    850                 855                 860                 


Ile Lys Pro Tyr Gln Glu Ile Ser Asn Tyr Leu Phe Ala Tyr Phe Ala 
865                 870                 875                 880 


Ser Gln Gln Ile Asn Glu Ala Arg Glu Glu Glu Gln Ile Asn Gln Thr 
                885                 890                 895     


Lys Arg Ala Leu Ala Gly Asn Met Ile Gly Val Ile Tyr Tyr Leu Tyr 
            900                 905                 910         


Gln Lys Tyr Arg Gly Ile Ile Ser Ile Glu Asp Leu Lys Gln Thr Lys 
        915                 920                 925             


Val Glu Ser Asp Arg Asn Lys Phe Glu Gly Asn Ile Glu Arg Pro Leu 
    930                 935                 940                 


Glu Trp Ala Leu Tyr Arg Lys Phe Gln Gln Glu Gly Tyr Val Pro Pro 
945                 950                 955                 960 


Ile Ser Glu Leu Ile Lys Leu Arg Glu Leu Glu Lys Phe Pro Leu Lys 
                965                 970                 975     


Asp Val Lys Gln Pro Lys Tyr Glu Asn Ile Gln Gln Phe Gly Ile Ile 
            980                 985                 990         


Lys Phe Val Ser Pro Glu Glu Thr  Ser Thr Thr Cys Pro  Lys Cys Leu 
        995                 1000                 1005             


Arg Arg  Phe Lys Asp Tyr Asp  Lys Asn Lys Gln Glu  Gly Phe Cys 
    1010                 1015                 1020             


Lys Cys  Gln Cys Gly Phe Asp  Thr Arg Asn Asp Leu  Lys Gly Phe 
    1025                 1030                 1035             


Glu Gly  Leu Asn Asp Pro Asp  Lys Val Ala Ala Phe  Asn Ile Ala 
    1040                 1045                 1050             


Lys Arg  Gly Phe Glu Asp Leu  Gln Lys Tyr Lys Ser  Arg Ala Asp 
    1055                 1060                 1065             


Pro Lys  Lys Lys Arg Lys Val  
    1070                 1075 


<210>  86
<211>  1117
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.7-NLSںϵ׵İ

<400>  86

Met Leu Ile Gln Phe Lys Asn His Tyr Ser Tyr Asn Lys Ser Ile Arg 
1               5                   10                  15      


Phe Lys Leu Glu His Lys Asn Gly Lys Leu Pro Lys Leu Glu Ser Asp 
            20                  25                  30          


Asn Val Asp Leu Asn Lys Leu Val Asp Ile Gly Asn Ser Leu Lys Asp 
        35                  40                  45              


Ile Phe Glu Glu Leu Val Tyr Thr Lys Asn Asn Tyr Asn Lys Leu Asn 
    50                  55                  60                  


Ser Leu Val Ser Ile Lys Lys Gln Trp Leu Lys Ile Tyr Phe Lys Asn 
65                  70                  75                  80  


Glu Phe Tyr Ser Asn Gly Lys Ile Gln Asn Tyr Ser Leu Ser Asn Phe 
                85                  90                  95      


Ser Tyr Leu Pro Asn Lys Leu Ile Glu Trp Leu Asn Asn Trp Gln Asn 
            100                 105                 110         


Asn Leu Lys Ala Leu Ile Glu Leu Thr Lys Gln Gln Asp Phe Asn Lys 
        115                 120                 125             


Thr Lys Lys Ser Glu Ile Ala Tyr Ile Leu Ser Leu Phe Asn Gly Lys 
    130                 135                 140                 


Tyr Ser Phe Ser Phe Val Lys Asp Phe Ser Thr Cys Ile Asn His Lys 
145                 150                 155                 160 


Asn Ser Gln Glu Gln Ile Leu Lys Leu Gln Gly Val Val Glu Asn Phe 
                165                 170                 175     


Glu Lys Val Leu Asn Leu Cys Ile Gln Glu Tyr Leu Pro Ser Lys Ser 
            180                 185                 190         


Ala Gly Val Val Ile Ala Gln Gly Ser Met Asn Tyr Tyr Ala Ile Asn 
        195                 200                 205             


Lys Glu Pro Lys Arg Tyr Asp Asn Ile Leu Ala Asp Leu Asn Gln Lys 
    210                 215                 220                 


Phe Glu Glu Leu Asp Lys Glu Tyr Ile Ala Met Lys Gln Tyr Lys Ser 
225                 230                 235                 240 


Ser Gln Lys Ser Arg Leu Phe Glu Phe Ile Arg Lys Gly Phe Ser Lys 
                245                 250                 255     


Asp Gln Ile Leu Ser Glu Phe Lys Lys Lys Glu Asn Asn Glu Val Ser 
            260                 265                 270         


Phe Val Tyr Asn Asn Gln Ile Ile Ile Arg Ile Tyr Thr Gln Glu Leu 
        275                 280                 285             


Phe Lys Asp Ser Tyr Cys Leu Gly Glu Val Ile Lys Leu Thr Lys Lys 
    290                 295                 300                 


Ile Glu Glu Leu Asn Glu Ser Lys Asp Ser Asn Asn Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Thr Lys Lys Glu Ile Thr Lys Leu Lys Lys Glu Ile Gly Phe Tyr 
                325                 330                 335     


Phe Ile Arg Arg Thr Arg Gly Lys Ser His Asn Asn Tyr Phe Lys Ser 
            340                 345                 350         


Tyr Tyr Gly Phe Cys Asn Asp Lys Phe Lys Lys Lys Ala Gln Glu Arg 
        355                 360                 365             


Gly Arg Leu Leu Thr Lys Ile Lys Ala Ile Arg Lys Glu Lys Ile Glu 
    370                 375                 380                 


Ser Gln Asn Leu Arg Tyr Trp Ser Leu Ile Leu Asp Asp Gly Lys Asp 
385                 390                 395                 400 


Lys Phe Leu Trp Leu Val Pro Lys Glu Asn Met Gln Glu Phe Arg Arg 
                405                 410                 415     


Glu Leu Ser Lys Ile His Pro Ser Gly Glu Ser Ser Leu Phe Leu Phe 
            420                 425                 430         


His Ser Leu Thr Met Arg Ala Leu His Lys Leu Cys Phe Ala Gln Glu 
        435                 440                 445             


Ser Asp Phe Val Lys Glu Met Pro Lys Val Leu Lys Glu Glu Gln Leu 
    450                 455                 460                 


Asn Cys Glu Lys Ala Ser Asn Asp Thr Glu Thr Asn Lys Arg Ile Lys 
465                 470                 475                 480 


Arg Asn Phe Gly Leu Asn Tyr Ile Lys Thr Lys Asp Glu Leu Thr Leu 
                485                 490                 495     


Ser Phe Leu Lys Lys Leu Ile Ile Ser Glu Tyr Ala His Glu Arg Leu 
            500                 505                 510         


Asp Leu Asn His Phe Asp Leu Ser Lys Leu Gln Val Ala Thr Thr Leu 
        515                 520                 525             


Asn Glu Phe Glu Glu Tyr Leu Glu Asp Ala Cys Tyr Tyr Leu Glu Lys 
    530                 535                 540                 


Ile Ser Ile Ser Ser Ser Met Ile Lys Glu Leu Leu Glu Glu Tyr Asn 
545                 550                 555                 560 


Ile Leu Asn Phe Arg Ile Thr Ser Tyr Asp Leu Glu Lys Arg Asn Lys 
                565                 570                 575     


Asn Thr Tyr Gln Thr Pro Glu Ser Asp Ile Lys Arg His Thr Lys Glu 
            580                 585                 590         


Ile Trp Asn Lys Phe Trp Glu Gly Asp Arg Phe Ile Arg Leu Asn Pro 
        595                 600                 605             


Glu Ile Lys Ile Arg Tyr Arg Gln Lys Asn Gln Asn Ile Glu Asp Tyr 
    610                 615                 620                 


Leu Lys Glu Lys Gly Phe Asp Leu Thr Lys Ile Lys Asn Arg Phe Leu 
625                 630                 635                 640 


Gln Glu Gln Tyr Ser Val Ser Phe Thr Phe Ala Leu Asn Ala Gly Lys 
                645                 650                 655     


Lys Tyr Pro Lys Leu Ala Phe Val Lys Thr Glu Glu Ile Leu Glu Lys 
            660                 665                 670         


Ile Glu Glu Phe Asn Asp Glu Phe Asn Lys Gln Tyr Phe Asp Asn Ser 
        675                 680                 685             


Tyr Lys Tyr Gly Ile Asp Arg Gly Asn Ile Glu Leu Ala Thr Leu Cys 
    690                 695                 700                 


Ile Thr Lys Phe Asn Lys Asn Asp Thr Tyr Glu Tyr Lys Gly Lys Lys 
705                 710                 715                 720 


Tyr Leu Lys Pro Asn Phe Pro Thr Ser Gln Glu Asp Ile Lys Thr Tyr 
                725                 730                 735     


Glu Leu Lys Asn Glu Trp Tyr Lys Arg Thr Ala Ile Ser Asn Ile Glu 
            740                 745                 750         


Thr Lys Pro Lys Asn Lys Lys Thr Pro Lys Arg Ile Ile Ala Asn Ile 
        755                 760                 765             


Ser Tyr Phe Ile Asp Asn Val Glu Asn Glu Glu Trp Phe Asn Lys Lys 
    770                 775                 780                 


Thr Cys Thr Ser Ile Asp Leu Thr Thr Ala Lys Val Ile Lys Gly Lys 
785                 790                 795                 800 


Leu Ile Leu Asn Gly Asp Val Leu Thr Phe Leu Lys Leu Lys Lys Glu 
                805                 810                 815     


Ala Ala Lys Arg Ile Leu Phe Glu Leu Val Ala Gln Asn Lys Leu Thr 
            820                 825                 830         


Ala Lys Asn Lys Glu Leu Lys Trp Lys Ser Asp Asp Gly Asn Asn Ser 
        835                 840                 845             


Asp Ser Val Arg Leu Ile Cys Asp Val Leu Asp Asn Glu Thr Asn Ser 
    850                 855                 860                 


Ile Tyr Phe Tyr Glu Asp Ser Lys Tyr Gly Arg Gly Phe Glu Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Asp Lys Thr Ala Tyr Ser Lys Glu Gly Ile Arg Ile Asn 
                885                 890                 895     


Leu Gln Asn Tyr Leu Asn His Leu Ile Ser Glu Lys Glu Asn Lys Ser 
            900                 905                 910         


Asn Lys Ala Tyr Ser His Val Pro Ser Ile Glu Lys Ile Asn His Leu 
        915                 920                 925             


Arg Asp Ala Leu Val Ala Asn Met Val Gly Val Ile Ser Tyr Leu Gln 
    930                 935                 940                 


Ala Tyr Tyr Pro Gly Ile Val Val Leu Glu Asp Leu Asn His Lys Leu 
945                 950                 955                 960 


Leu Ile Lys His Phe Glu Asp Leu Asn Ile Asn Ile Ser Asn Arg Phe 
                965                 970                 975     


Glu His Ala Leu Ile Glu Lys Phe Gln Thr Leu Gly Met Val Pro Pro 
            980                 985                 990         


His Ile Lys Asp Tyr Leu Glu Ile  Arg Ser Ser Phe Arg  Met Ser Arg 
        995                 1000                 1005             


Asn Asp  Ser Ser Gln Phe Gly  Ala Leu Ile Phe Val  Ser Lys Glu 
    1010                 1015                 1020             


Gly Thr  Ser Lys Glu Cys Pro  Tyr Cys Glu Lys Lys  Trp Asn Trp 
    1025                 1030                 1035             


Gly Lys  Glu Lys Glu Ile Glu  Leu Lys Phe Ser Lys  Lys Gln Tyr 
    1040                 1045                 1050             


Ile Cys  Gly Lys Glu Asn Ser  Cys Gly Phe Asp Thr  Lys His Ile 
    1055                 1060                 1065             


Gln Asn  Thr Phe Glu Phe Leu  Ser Glu Ile Asn Asp  Pro Asp Lys 
    1070                 1075                 1080             


Ile Ala  Ala Tyr Asn Ile Ala  Lys Arg Gly Phe Lys  Ser Phe Ile 
    1085                 1090                 1095             


Asn Lys  Ser Ser Ile Lys Lys  Gln Ser Arg Ala Asp  Pro Lys Lys 
    1100                 1105                 1110             


Lys Arg  Lys Val 
    1115         


<210>  87
<211>  1096
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.8-NLSںϵ׵İ

<400>  87

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Leu Pro 
1               5                   10                  15      


Asp Lys Ile Gln Asp Ile Ser Arg Gln Val Ala Val Leu Gln Asn Ser 
            20                  25                  30          


Thr Asn Ala Glu Lys Lys Asn Asn Leu Leu Arg Leu Ile Gln Arg Gly 
        35                  40                  45              


Gln Glu Leu Pro Lys Leu Leu Asn Glu Tyr Ile Arg Tyr Ser Asp Asn 
    50                  55                  60                  


His Lys Leu Lys Ser Asn Val Thr Val His Phe Arg Trp Leu Arg Leu 
65                  70                  75                  80  


Phe Thr Lys Asp Leu Phe Tyr Asn Trp Lys Lys Asp Asn Thr Glu Lys 
                85                  90                  95      


Lys Ile Lys Ile Ser Asp Val Asp Tyr Leu Ser Arg Val Phe Glu Asp 
            100                 105                 110         


Phe Phe Asn Glu Trp Glu Thr Val Ile Glu Arg Ile Asn Thr Asp Cys 
        115                 120                 125             


Asn Arg Pro Glu Glu Ser Lys Thr Arg Asp Ala Glu Ile Ala Phe Ser 
    130                 135                 140                 


Ile Lys Lys Ile Ala Thr Lys Gln Met Phe Pro Phe Ile Lys Ser Phe 
145                 150                 155                 160 


Val Tyr Asn Ser Asn Tyr Lys Asn Ser Glu Glu Thr Lys Ser Lys Leu 
                165                 170                 175     


Thr Ala Leu Leu Asn Glu Phe Glu Thr Val Leu Lys Ile Cys Glu Gln 
            180                 185                 190         


Asn Tyr Leu Pro Ser Gln Ser Ala Gly Ile Val Ile Ala Lys Ala Ser 
        195                 200                 205             


Phe Asn Tyr Tyr Thr Ile Asn Lys Lys Gln Lys Asp Tyr Lys Gly Tyr 
    210                 215                 220                 


Thr Asp Asp Ile Glu Lys Ile Glu Lys Gly Met Asn Ser Lys Phe His 
225                 230                 235                 240 


Tyr Glu Arg Lys Tyr Asp Gln Leu Leu Glu Glu Leu Asn Leu Ile Ala 
                245                 250                 255     


Leu Lys Glu Leu Pro Leu Ile Glu Phe Tyr Ser Lys Ile Lys Ser Tyr 
            260                 265                 270         


Lys Ser Thr Arg Lys Ile Glu Phe Ser Glu Ala Val Ser Lys Gly Leu 
        275                 280                 285             


Ala Phe Ala Asp Leu Lys Ser Lys Phe Pro Leu Phe Gln Thr Glu Ser 
    290                 295                 300                 


Asn Lys Tyr Ala Glu Phe Leu Glu Leu Thr Gly Arg Ile Thr Gln Ile 
305                 310                 315                 320 


Ser Thr Ala Lys Ser Leu Leu Ser Lys Asp Asn Pro Glu Ala Gln Lys 
                325                 330                 335     


Leu Arg Asp Glu Ile Lys Lys Leu Arg Ile Asn Arg Gly Glu Tyr Phe 
            340                 345                 350         


Lys Asn Asn Phe His Lys Tyr Ile Ser Leu Cys Asn Leu Tyr Lys Lys 
        355                 360                 365             


Ile Ala Asp Lys Lys Gly Arg Leu Lys Gly Gln Val Lys Gly Ile Glu 
    370                 375                 380                 


Asn Glu Arg Ile Asp Ser Gln Arg Ile Gln His Trp Ala Leu Val Leu 
385                 390                 395                 400 


Glu Asp Asn Leu Lys His Ser Leu Ile Leu Ile Pro Lys Glu Lys Val 
                405                 410                 415     


Thr Glu Val Tyr Arg Lys Val Arg Ala Ser Lys Ala Asp Ser Thr Ser 
            420                 425                 430         


Ser Ser Ser Ser Leu Tyr Tyr Phe Glu Ser Met Thr Tyr Arg Ala Leu 
        435                 440                 445             


His Lys Leu Cys Phe Gly Val Asn Gly Asn Thr Phe Leu Pro Glu Ile 
    450                 455                 460                 


Gln Lys Glu Leu Pro Glu Tyr Asn Pro Asn Lys Gln Ser Asp Phe Gly 
465                 470                 475                 480 


Glu Phe Cys Phe His Lys Ser Asn Thr Asp Lys Glu Ile Asp Glu Pro 
                485                 490                 495     


Lys Leu Ile Ser Phe Tyr Gln Ser Val Leu Lys Thr Asn Tyr Val Lys 
            500                 505                 510         


Asp Asn Leu Asn Leu Pro Gln Ser Val Phe Asp Glu Ala Thr Val Gln 
        515                 520                 525             


Thr Phe Glu Thr Arg Gln Asp Phe Gln Ile Ala Leu Glu Lys Cys Cys 
    530                 535                 540                 


Tyr Ala Lys Lys Thr Ile Ile Ser Glu Thr Leu Lys Lys Glu Ile Leu 
545                 550                 555                 560 


Glu Asp Asn Asn Val Gln Ile Phe Gln Ile Thr Ser Leu Asp Leu Gln 
                565                 570                 575     


Arg Ser Glu Gln Lys Asn Leu Lys Ala His Thr Lys Ile Trp Asn Arg 
            580                 585                 590         


Phe Trp Thr Lys Gln Asn Glu Thr Ala Asn Tyr Asp Leu Arg Leu Asn 
        595                 600                 605             


Pro Glu Thr Ala Ile Val Trp Arg Lys Pro Lys Lys Thr Arg Ile Asp 
    610                 615                 620                 


Lys Tyr Gly Ala Gly Thr Ser Leu Tyr Asp Pro Lys Lys Arg Asn Arg 
625                 630                 635                 640 


Tyr Leu His Glu Gln Tyr Thr Leu Cys Thr Thr Val Thr Asp Asn Ala 
                645                 650                 655     


Leu Asn Asn Glu Ile Thr Phe Ala Phe Glu Asp Thr Lys Lys Lys Gly 
            660                 665                 670         


Thr Glu Ile Val Lys Tyr Asn Glu Lys Ile Asn Gln Thr Leu Lys Lys 
        675                 680                 685             


Glu Phe Asn Lys Asn Gln Leu Trp Phe Tyr Gly Ile Asp Ala Gly Glu 
    690                 695                 700                 


Ile Glu Leu Ala Thr Leu Ala Leu Met Asn Lys Asp Lys Glu Pro Gln 
705                 710                 715                 720 


Leu Phe Thr Val Tyr Glu Leu Lys Lys Ser Asp Phe Phe Lys His Gly 
                725                 730                 735     


Tyr Ile Tyr Asn Lys Glu Arg Glu Leu Val Ile Arg Glu Lys Pro Tyr 
            740                 745                 750         


Lys Ala Ile Gln Asn Leu Ser Tyr Phe Leu Asn Glu Glu Leu Tyr Glu 
        755                 760                 765             


Lys Thr Phe Arg Asp Gly Lys Phe Gln Glu Thr Phe Asn Glu Leu Phe 
    770                 775                 780                 


Lys Glu Lys His Val Ser Ala Ile Asp Leu Thr Thr Ala Lys Val Ile 
785                 790                 795                 800 


Asn Gly Lys Ile Ile Leu Asn Gly Asp Met Ile Thr Phe Leu Asn Leu 
                805                 810                 815     


Arg Ile Leu His Ala Lys Arg Lys Ile Tyr Glu Glu Leu Ile Ile Asn 
            820                 825                 830         


Pro Gln Ala Glu Leu Lys Glu Asn Glu Lys Glu Tyr Tyr Leu Tyr Phe 
        835                 840                 845             


Asp Lys Glu Gly Thr Glu Lys Val Glu Lys Ile Tyr Arg Ser Arg Leu 
    850                 855                 860                 


Asp Phe Glu His Ile Lys Pro Tyr Gln Glu Ile Arg Asn Asp Leu Asn 
865                 870                 875                 880 


Ala Tyr Phe Lys Asn Val Gln Lys Asn Glu Ala Lys Val Glu Asp Gln 
                885                 890                 895     


Ile Asn Gln Thr Arg Arg Ala Leu Val Gly Asn Met Ile Gly Val Ile 
            900                 905                 910         


Tyr Tyr Leu Tyr Gln Lys Tyr Arg Gly Ile Ile Ser Ile Glu Asp Leu 
        915                 920                 925             


Lys Gln Thr Lys Val Glu Ser Asp Arg Asn Lys Phe Glu Gly Asn Ile 
    930                 935                 940                 


Glu Arg Pro Leu Glu Trp Ala Leu Tyr Arg Lys Phe Gln Gln Glu Gly 
945                 950                 955                 960 


Tyr Val Pro Pro Ile Ser Glu Leu Ile Lys Leu Arg Glu Leu Glu Lys 
                965                 970                 975     


Phe Pro Leu Lys Asp Val Lys Gln Pro Lys Tyr Glu Asn Ile Gln Gln 
            980                 985                 990         


Phe Gly Ile Ile Lys Phe Val Ser  Pro Glu Glu Thr Ser  Thr Thr Cys 
        995                 1000                 1005             


Pro Ser  Cys Glu Lys Lys Ala  Tyr Glu Leu Gln Lys  Glu Lys Lys 
    1010                 1015                 1020             


Gly Glu  Glu Lys Pro Ala Glu  Asn Lys Arg Tyr Glu  Ala Asp Lys 
    1025                 1030                 1035             


Lys Ala  Gly Val Phe Cys Cys  Pro Lys Cys Gly Phe  His Asn Arg 
    1040                 1045                 1050             


Thr Asn  Pro Met Gly Tyr Glu  Ser Leu Asp Ser Asn  Asp Lys Val 
    1055                 1060                 1065             


Ala Ala  Phe Asn Ile Ala Lys  Arg Gly Phe Glu Asp  Leu Gln Lys 
    1070                 1075                 1080             


His Lys  Ser Arg Ala Asp Pro  Lys Lys Lys Arg Lys  Val 
    1085                 1090                 1095     


<210>  88
<211>  1044
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.9-NLSںϵ׵İ

<400>  88

Met Glu Asn Ser Asn Leu Tyr Gln Val Val Lys Thr Ile Arg Phe Lys 
1               5                   10                  15      


Leu Glu Pro Val Gly Lys Met Asp Thr Pro Lys Phe Gly Asp Lys Asn 
            20                  25                  30          


Ala Glu Ser Lys Ala Asn Leu Thr Pro Phe Ile Glu Leu Val Lys Lys 
        35                  40                  45              


Thr Met Thr Asn Val Lys Ala Leu Val Phe Ser Lys Gln Asp Gly Glu 
    50                  55                  60                  


Asp Gly Glu Lys Trp Arg Lys Ile Leu Glu Val Asn Tyr Arg Phe Leu 
65                  70                  75                  80  


Arg Ser Tyr Leu Lys Asn Ser Phe Tyr Glu Asn Arg Gly Asp Ser Gln 
                85                  90                  95      


Glu Lys Ser Lys Lys His Lys Ile Ser Asp Leu Glu Tyr Leu Gln Lys 
            100                 105                 110         


Ala Leu Glu Asn Leu Phe Ala Glu Phe Asp Glu Ile Leu Asp Gly Leu 
        115                 120                 125             


Glu Asp Phe Glu Lys Arg Asn Thr Lys Asn Gln Tyr Glu Lys Gln Arg 
    130                 135                 140                 


His Ala Gln Ala Gly Leu Leu Leu Asn Arg Leu Cys Lys Arg Ser Asn 
145                 150                 155                 160 


Phe Gly Phe Leu Lys Ala Phe Val Gly Ala Leu Ala Gln Thr Asn Lys 
                165                 170                 175     


Pro Phe Phe Asp Asp Lys Thr Asp Lys Leu Lys Lys Gln Ile Asp Lys 
            180                 185                 190         


Phe Glu Thr Glu Leu Glu Lys Gln Lys Glu Phe Phe Leu Pro Tyr Gln 
        195                 200                 205             


Ser Asn Gly Val Leu Phe Ala Gly Gly Ser Phe Asn Arg Tyr Ala Ile 
    210                 215                 220                 


Asn Lys Thr Pro Lys Met Leu Asp Lys Glu Leu Arg Glu Glu Gln Thr 
225                 230                 235                 240 


Asn Leu Lys Lys Ser Leu Cys Glu His Lys Ile Lys Ile Asp Thr Leu 
                245                 250                 255     


Asn Thr Leu Gly Leu Lys Asn Asp Cys Pro Cys Thr Ser Leu Asp Asn 
            260                 265                 270         


Ser Tyr Thr Phe Ile Lys Asp Tyr Lys Ala Lys Gln Lys Ser Lys Phe 
        275                 280                 285             


Ile Glu Leu Val Gln Lys Gly Glu Phe Asp Glu Ala Lys Lys Val Asn 
    290                 295                 300                 


Leu Phe Glu Cys Ser Glu Thr Asp Phe Glu Thr Phe Lys Thr Arg Thr 
305                 310                 315                 320 


Lys Gln Ile Gln Asn Glu Lys Asp Lys Asp Glu Arg Thr Lys Leu Lys 
                325                 330                 335     


Gln Lys Arg Gly Glu Phe Phe Lys Ser Gln Lys Arg Gly Lys Phe Phe 
            340                 345                 350         


Lys Ser Gln Thr Gln Asn Tyr Glu Asn Leu Cys Asp Leu Tyr Lys Lys 
        355                 360                 365             


Ile Ala Gln Lys Arg Gly Gln Ile Val Ala Lys Ile Cys Ala Ile Lys 
    370                 375                 380                 


Lys Glu Lys Glu Met Cys Glu Gln Val Lys Tyr Trp Cys Val Ala Leu 
385                 390                 395                 400 


Glu Lys Gly Gly Glu Phe Tyr Leu Tyr Met Phe Leu Arg Asp Glu Asn 
                405                 410                 415     


Asp Asn Ile Lys Asn Ala Tyr Asp Phe Val Ser Lys Leu Gln Thr Gln 
            420                 425                 430         


Lys Ser Gly Glu Thr Lys Leu His Tyr Phe Asp Ser Leu Thr Leu Lys 
        435                 440                 445             


Ala Val Arg Lys Leu Cys Phe Lys Glu Thr Asp Gly Ser Phe Lys Lys 
    450                 455                 460                 


Ala Leu Lys Asn Val Lys Phe Pro Glu Cys Glu Gln Asn Leu Asp Glu 
465                 470                 475                 480 


Lys Val Lys Ile Ser Phe Tyr Gln Asn Val Leu Lys Asn Ala Lys Thr 
                485                 490                 495     


Leu Asn Leu Ser Lys Phe Glu Asn Leu Gln Ser Val Thr Glu Gly Lys 
            500                 505                 510         


Phe Glu Ser Leu Ser Glu Phe Glu Val Ala Leu Asn Met Val Cys Tyr 
        515                 520                 525             


Thr Lys Thr Val Cys Val Ser Glu Ser Val Glu Lys Glu Leu Lys Lys 
    530                 535                 540                 


Phe Lys Pro Leu Val Phe His Ile Thr Ser Gln Asp Leu Ala Ala Lys 
545                 550                 555                 560 


Arg Glu Lys Lys Ala His Thr Gln Ile Trp His Glu Phe Trp Arg Glu 
                565                 570                 575     


Ser Asn Glu Lys Ser Lys Phe Pro Leu Arg Leu Asn Pro Glu Leu Lys 
            580                 585                 590         


Val Met Trp Arg Glu Ala Arg Pro Ser Arg Val Glu Lys Tyr Ala Glu 
        595                 600                 605             


Gln Ser Asp Lys Phe Asp Pro Asn Lys Lys Asn Arg Tyr Leu His Pro 
    610                 615                 620                 


Gln Phe Thr Leu Ala Leu Asn Phe Thr Gln Asn Ala His Asn Glu Ala 
625                 630                 635                 640 


Ile Asn Leu Ala Phe Lys Asp Val Gln Asn Lys Gly Glu Ala Val Lys 
                645                 650                 655     


Lys Phe Asn Glu Asn Phe Lys Ser Ser Glu Tyr Ala Phe Gly Ile Asp 
            660                 665                 670         


Val Gly Thr Lys Asp Leu Ala Leu Leu Cys Leu Ile Asp Lys Asn Lys 
        675                 680                 685             


Lys Pro Val Asn Phe Asp Val Tyr Glu Ile Cys Asn Glu Asn Glu Ile 
    690                 695                 700                 


Cys Asn Glu Lys Leu Gly Phe Glu Lys Phe Gly Phe Tyr Lys Asp Gly 
705                 710                 715                 720 


Thr Arg Arg Asp Glu Pro Tyr Lys Leu Ile Lys Asn Pro Ser Tyr Phe 
                725                 730                 735     


Leu Asn Glu Ser Leu Tyr Lys Lys Thr Phe Asn Ala Thr Lys Glu Glu 
            740                 745                 750         


Phe Glu Arg Ser Phe Ser Glu Leu Phe Lys Arg Lys Ser Val Cys Ala 
        755                 760                 765             


Leu Asp Leu Thr Thr Ala Lys Val Ile Cys Gly Lys Ile Ile Leu Asn 
    770                 775                 780                 


Gly Asp Phe Ser Thr His Leu Asn Leu Lys Ile Leu Asn Ala Lys Arg 
785                 790                 795                 800 


Lys Ile Ser Ala Lys Leu Lys Lys Asp Pro Thr Leu Lys Ile Glu Tyr 
                805                 810                 815     


Asp Asn Asp Asp Asn Ile Leu Phe Gly Ser Asn Val Ile Phe Tyr Tyr 
            820                 825                 830         


Asn Asn Lys Tyr Glu Ile Val Arg Pro Tyr Asp Glu Ile Lys Asn Glu 
        835                 840                 845             


Ile Phe Glu Phe His Glu Lys Gln Arg Leu Asp Asp Ala Arg Leu Glu 
    850                 855                 860                 


Asp Asn Ile Asn Lys Thr Arg Ala Asn Leu Val Ala Asn Met Val Gly 
865                 870                 875                 880 


Val Ile Ser Phe Leu His Lys Glu Phe Ser Gly Phe Val Val Leu Glu 
                885                 890                 895     


Asn Leu Lys Gln Ser Glu Ile Glu Gly Asn His Arg Leu Lys Phe Glu 
            900                 905                 910         


Gly Asp Ile Thr Arg Pro Leu Glu Leu Ala Leu Tyr Arg Lys Phe Gln 
        915                 920                 925             


Ser Lys Cys Leu Thr Pro Pro Ile Ser Glu Leu Ile Lys Leu Arg Glu 
    930                 935                 940                 


Gly Glu Lys Asn Glu Asn Val Glu Ser Asp Leu Ile Leu Gln Phe Gly 
945                 950                 955                 960 


Ile Ile Lys Phe Val Asp Lys Asp Lys Thr Ser Arg Leu Cys Pro Ala 
                965                 970                 975     


Cys Gly Lys Asp Ala Tyr Glu Asn Asn Asn Ser Lys Tyr Lys Thr Asp 
            980                 985                 990         


Lys Lys Asp Gly Val Phe Glu Cys  Ala Gly Cys Gly Phe  Asn Asn Lys 
        995                 1000                 1005             


Asn Asn  Ala Gly Asp Phe Ala  Ala Leu Asp Thr Asn  Asp Lys Ile 
    1010                 1015                 1020             


Ala Thr  Phe Asn Ile Ala Lys  Arg Gly Leu Ser Arg  Ala Asp Pro 
    1025                 1030                 1035             


Lys Lys  Lys Arg Lys Val 
    1040                 


<210>  89
<211>  1179
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.10-NLSںϵ׵İ

<400>  89

Met Glu Thr Tyr Lys Ile Thr Lys Thr Ile Arg Phe Lys Leu Glu Ala 
1               5                   10                  15      


Asp Glu Glu Asn Ser Ile His Ile Lys Glu Asp Ile Ile Asn Ile Glu 
            20                  25                  30          


Thr Asn Asp Asn Glu Phe Thr Met Val Asp Phe Val Ser Asn Leu Gly 
        35                  40                  45              


Asn Tyr Ile Lys Asp Leu Lys Asn Tyr Leu Phe Tyr Glu Lys Lys Asp 
    50                  55                  60                  


Gly Ser Leu Ser Phe Lys Asp Lys Ile Ile Ile Lys Asn Glu Trp Leu 
65                  70                  75                  80  


Arg Gln Tyr Ala Lys Gln Asp Phe Val Glu Leu Lys Ser Lys Lys Arg 
                85                  90                  95      


Ile Asn Leu Arg Asn Asn Arg Met Glu Gln Ile Lys Ile Gly Asp Ile 
            100                 105                 110         


Pro Arg Leu Ser Ser Lys Ile Glu Glu Ala Leu Asp Ile Ala Lys Glu 
        115                 120                 125             


Ile Tyr Ser Lys Leu Ser Asp Asp Ala Thr Leu Glu Gln His Glu Arg 
    130                 135                 140                 


Thr Lys Lys Ala Gln Ile Gly Leu Leu Leu Lys Arg Leu Glu Ala Lys 
145                 150                 155                 160 


Asn Val Leu Pro Leu Leu Met Asp Leu Val Lys Glu Thr Leu Asp Lys 
                165                 170                 175     


Asp Glu Thr Asp Asp Leu Ser Ile Arg Leu Lys Arg Gln Ser Gln Lys 
            180                 185                 190         


Ile Asn Ser Gln Leu Lys Ile Ala Ile Arg Ser Phe Leu Pro Glu Gln 
        195                 200                 205             


Ser Asn Gly Leu Gln Ile Ala Lys Ala Ser Phe Asn Tyr Tyr Thr Ile 
    210                 215                 220                 


Asn Lys Lys Pro Ile Asp Phe Glu Lys Lys Ile Glu Asp Leu Lys Lys 
225                 230                 235                 240 


Asn Leu Asn Val Lys Asp Leu Glu Lys Leu Asn Val Tyr Phe Asp Lys 
                245                 250                 255     


Lys Glu Lys Lys Gln Lys Asn Tyr Leu Gly Lys Lys Ile Phe Ser Leu 
            260                 265                 270         


Phe Glu Thr Asp Ile Gln Lys Ala Leu Ser Lys Asn Gln Pro Leu Tyr 
        275                 280                 285             


Leu Gly Asp Ala Pro Met Ile Asp Ser Ala Tyr Val Ser Leu Arg Gln 
    290                 295                 300                 


Ile Phe Lys Lys Ile Lys Ser Glu Gln Lys Lys Gln Phe Ser Glu Leu 
305                 310                 315                 320 


Met Gln Asn Lys Cys Ser Tyr Asp Glu Leu Lys Asn Ser Asn Leu Tyr 
                325                 330                 335     


Leu Leu Asn Asp Ile Gly Leu Glu Gln Phe Asn Thr Tyr Arg Glu Lys 
            340                 345                 350         


Thr Lys Glu Leu Glu Glu Leu Ala Thr Lys Leu Ser Asn Gln Asn Leu 
        355                 360                 365             


Leu Glu Asn Ala Lys Glu Arg Leu Arg Ser Gln Lys Glu Lys Ile Ala 
    370                 375                 380                 


Lys Glu Arg Gly Asn Ile Met Lys Asp Arg Phe Gln Thr Trp Lys Ser 
385                 390                 395                 400 


Phe Ala Asn Phe Tyr Arg Thr Val Ser Gln Lys His Gly Lys Ile Leu 
                405                 410                 415     


Ala Gln Leu Lys Gly Ile Glu Lys Glu Gln Ala Glu Ser Gln Leu Leu 
            420                 425                 430         


Lys Tyr Trp Ala Leu Ile Cys Glu Lys Glu Asn Gln His Gln Leu Trp 
        435                 440                 445             


Leu Ile Pro Arg Glu Lys Ala Trp Glu Cys Lys Arg Trp Leu Glu Thr 
    450                 455                 460                 


Val Asn Asp Thr Ser Ile Asp Asn Glu Asn Ser Ile Lys Leu Tyr Trp 
465                 470                 475                 480 


Phe Glu Ser Leu Thr Tyr Arg Ser Leu Gln Lys Leu Cys Phe Gly Phe 
                485                 490                 495     


Leu Glu Asn Gly Asn Asn Glu Phe Asn Gln Asn Ile Lys Asp Leu Leu 
            500                 505                 510         


Pro Lys Asp Arg Ile Gly Asn Thr Ile Asn Gly Glu Phe Ala Phe Glu 
        515                 520                 525             


Gly Asp Glu Glu Arg Lys Ile Glu Phe Tyr Lys Thr Val Leu Asn Ser 
    530                 535                 540                 


Lys Tyr Ala Lys Gln Val Leu Asn Ile Pro Phe Lys Gln Val Glu Glu 
545                 550                 555                 560 


Glu Ile Ile Ser Gln Ser Phe Glu Asn Leu Ser Asp Phe Gln Ile Ala 
                565                 570                 575     


Leu Glu Lys Ile Cys Tyr Arg Arg Phe Ala Ile Tyr Ser Asn Tyr Ile 
            580                 585                 590         


Ile Ser Phe Asp Ala Gln Ile Phe Asp Ile Thr Ser Leu Asp Leu Lys 
        595                 600                 605             


Asn Asn Glu Lys Asn Asn Leu Asn Thr His Thr His Ile Trp Arg Asp 
    610                 615                 620                 


Phe Trp Lys Asp Glu Asn Glu Lys Asn Asn Phe Asp Ile Arg Leu Asn 
625                 630                 635                 640 


Pro Glu Ile Thr Ile Ser Tyr Arg Thr Pro Lys Gln Ser Arg Ile Glu 
                645                 650                 655     


Lys Tyr Gly Glu Lys Thr Lys Glu Tyr Asp Pro Asn Lys Asn Asn Arg 
            660                 665                 670         


Tyr Leu His Pro Gln Phe Thr Leu Ile Thr Thr Ile Ser Glu Arg Ser 
        675                 680                 685             


Asn Ser Gln Thr Lys Thr Leu Ser Phe Ile Glu Asp Glu Asp Phe Lys 
    690                 695                 700                 


Lys Ser Ile Asn Glu Phe Asn Lys Lys Leu Lys Lys Asp Asn Ile Lys 
705                 710                 715                 720 


Phe Ala Phe Gly Ile Asp Asn Gly Glu Val Glu Leu Ser Thr Leu Gly 
                725                 730                 735     


Val Tyr Leu Pro Thr Phe Glu Lys Glu Thr His Glu Glu Lys Ile Tyr 
            740                 745                 750         


Glu Leu Lys Gln Ile Lys Lys Tyr Gly Phe Glu Val Leu Thr Ile Thr 
        755                 760                 765             


Asp Leu Lys Tyr Lys Glu Thr Asp Tyr Asn Gly Asn Val Arg Lys Ile 
    770                 775                 780                 


Ile Gln Asn Pro Ser Tyr Phe Leu Lys Lys Glu Asn Tyr Ile Arg Thr 
785                 790                 795                 800 


Phe Ser Lys Ser Glu Gln Glu Tyr Glu Glu Met Phe Ala Lys Leu Phe 
                805                 810                 815     


Lys Lys Glu His Val Leu Ser Leu Asp Leu Thr Thr Ala Lys Met Ile 
            820                 825                 830         


Cys Gly His Ile Val Thr Asn Gly Asp Val Pro Ala Leu Phe Asn Leu 
        835                 840                 845             


Trp Leu Lys His Ala Gln Arg Asn Val Phe Glu Met Asn Asp His Thr 
    850                 855                 860                 


Val Lys Glu Thr Ala Lys Thr Ile Arg Leu Arg Asn Asn Glu Glu Leu 
865                 870                 875                 880 


Thr Asp Asn Glu Lys Glu Lys Phe Ala Glu Phe Ile Ser Asp Gly Lys 
                885                 890                 895     


Lys Phe Ala Lys Leu Thr Lys Glu Gly Lys Lys Ser Arg Tyr Leu Lys 
            900                 905                 910         


Trp Ile Phe Glu Asp Arg Lys Glu Asn Ser Phe Thr Glu Asp Glu Asn 
        915                 920                 925             


Lys Lys Phe Asn Asp Cys Gln Lys Lys Lys Gly Lys Tyr Asn Ser His 
    930                 935                 940                 


Ile Ile Phe Ala Ser Arg Phe Glu Gly Asp Glu Leu Lys Ser Val Thr 
945                 950                 955                 960 


Pro Ile Phe Asp Cys Arg His Val Phe Lys Lys Arg Lys Glu Phe Glu 
                965                 970                 975     


Thr Ile Arg Pro Ile Lys Glu Ile Glu Asn Glu Ile Ser Arg Phe Asn 
            980                 985                 990         


Thr Asn Arg Thr Ser His Asn Ile  Ser Asn Glu Glu Leu  Asp Leu Lys 
        995                 1000                 1005             


Ile Thr  Asp Ala Lys Lys Ala  Leu Val Ala Asn Ala  Ile Gly Val 
    1010                 1015                 1020             


Ile Asp  Phe Leu Tyr Lys Gln  Tyr Lys Gln Arg Phe  Asn Asp Glu 
    1025                 1030                 1035             


Gly Leu  Ile Ile Lys Glu Gly  Phe Asp Thr Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Asp Ile  Glu Lys Phe Ser Gly  Asn Ile Tyr Arg Ile  Leu Glu Arg 
    1055                 1060                 1065             


Lys Leu  Tyr Gln Lys Phe Gln  Asn Tyr Gly Leu Val  Pro Pro Ile 
    1070                 1075                 1080             


Lys Asn  Leu Met Ala Val Arg  Asn Glu Gly Ile Lys  Asp Lys Asn 
    1085                 1090                 1095             


Ala Ile  Leu Arg Leu Gly Asn  Ile Ala Phe Ile Asp  Pro Ser Gly 
    1100                 1105                 1110             


Thr Ser  Gln Glu Cys Pro Val  Cys Lys Glu Lys Ser  Lys Glu Lys 
    1115                 1120                 1125             


His Thr  Asn Asn Phe Ile Cys  Glu Cys Gly Phe Asn  Ser Thr Asn 
    1130                 1135                 1140             


Ile Met  His Ser Asn Asp Gly  Ile Ala Gly Phe Asn  Ile Ala Lys 
    1145                 1150                 1155             


Arg Gly  Phe Glu Asn Phe Ile  Asn Glu Lys Ser Arg  Ala Asp Pro 
    1160                 1165                 1170             


Lys Lys  Lys Arg Lys Val 
    1175                 


<210>  90
<211>  1198
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.11-NLSںϵ׵İ

<400>  90

Met Glu Lys Tyr Lys Ile Thr Lys Thr Ile Arg Phe Arg Leu Asp Ala 
1               5                   10                  15      


Asp Asn Thr Ala Ile Ser Ala Ile Val Lys Asp Thr Glu Ala Leu Glu 
            20                  25                  30          


Ala Arg Gly Gln Gly Phe Lys Ile Lys Lys Phe Val Asn Ala Leu Gly 
        35                  40                  45              


Arg Phe Leu Ser Gly Asp Gly Val Gln Lys Tyr Leu Tyr Asp Met Ser 
    50                  55                  60                  


Asn Glu Glu Asn Cys Val Phe Lys Arg Asn Leu Val Ile Lys Asn Thr 
65                  70                  75                  80  


Trp Leu Lys Asn Asn Ala Lys Gln Glu Ile Ala Gly Met Asp Leu Lys 
                85                  90                  95      


Arg Gly Leu Ile Ile Lys Asp Ile Lys Gly Leu Gln Asp Lys Ile Glu 
            100                 105                 110         


Glu Ile Tyr Asp Lys Leu Trp Glu Ile Tyr Glu Ile Leu Tyr Glu Ser 
        115                 120                 125             


Ala Tyr Leu Pro Leu Gln Asp Leu Ala Arg Arg Glu Gly Ile Gly Leu 
    130                 135                 140                 


Leu Leu Lys Lys Leu Ser Val Lys Asn Ala Leu Pro Phe Ile Ile Ser 
145                 150                 155                 160 


Phe Val Glu Glu Ser Asn Asp Lys Asn Glu Ala Asp Asp Leu Ser Leu 
                165                 170                 175     


Arg Leu Lys Lys Gln Gly Lys Glu Ile Leu Thr Gln Leu Glu Ile Gly 
            180                 185                 190         


Ile Asn Glu Tyr Leu Pro Ala Gln Ser Ser Gly Leu Pro Val Ala Lys 
        195                 200                 205             


Ala Ser Phe Asn Tyr Tyr Thr Ile Asn Lys Thr Pro Val Asp Phe Gly 
    210                 215                 220                 


Glu Lys Ile Gln Glu Leu Glu Lys Arg Leu Ser Val Asp Ile Lys Lys 
225                 230                 235                 240 


Glu Ile Ser Ser Phe Thr Gly Gly Ile Lys Thr Ala Ile Lys Asn Lys 
                245                 250                 255     


Ile Ala Gly Lys Lys Ile Leu Leu Gly Asp Thr Pro Met Phe Glu Ser 
            260                 265                 270         


Glu Asn Ser Val Ser Leu Arg Gln Ile Leu Lys Asn Ile Lys Ser Glu 
        275                 280                 285             


Gln Lys Ala Gln Phe Asn Lys Phe Met Thr Thr Gln Asn Asn Pro Gln 
    290                 295                 300                 


Leu Glu Glu Met Lys Thr Met Gly Trp Tyr Leu Phe Gly Asp Ile Thr 
305                 310                 315                 320 


Glu Gly Glu Phe Asn Asp Tyr Lys Glu Gln Thr Lys Glu Ile Glu Arg 
                325                 330                 335     


Val Gly Ala Lys Ile Asn Gln Cys Gly Asn Ile Lys Glu Lys Lys Glu 
            340                 345                 350         


Leu Arg Ser Gln Leu Gln Lys Leu Lys Lys Lys Arg Gly Glu Leu Ile 
        355                 360                 365             


Ser Glu Ala His Lys Lys Gly Gly Asn Asp Lys Asn Phe Lys Thr Tyr 
    370                 375                 380                 


Lys Glu Phe Ala Lys Phe Tyr Arg Lys Ile Ala Gln Arg His Gly Lys 
385                 390                 395                 400 


Ile Leu Ala Gln Ile Lys Gly Ile Glu Lys Glu Lys Ile Asp Ser Ala 
                405                 410                 415     


Met Leu Asn Tyr Trp Ala Ala Val Ile Glu Leu Ser Gly Arg His Lys 
            420                 425                 430         


Leu Val Leu Ile Pro Lys Lys Asp Glu Asn Ala Lys Lys Cys Ile Glu 
        435                 440                 445             


Trp Leu Glu Asp Glu Ser Lys His Lys Asn Gly Ser Cys Lys Ile Phe 
    450                 455                 460                 


Trp Phe Glu Ser Phe Thr Phe Arg Ser Leu Gln Lys Leu Cys Phe Gly 
465                 470                 475                 480 


Asn Leu Asp Ser Gly Thr Asn Thr Phe Asn Gln Lys Ile Gln Asn Leu 
                485                 490                 495     


Leu Pro Cys Asp Glu Arg Gly Asn Leu Met Asn Gly Glu Phe Ala Phe 
            500                 505                 510         


Lys Gly Asp Glu Gln Glu Lys Ile Lys Phe Tyr Lys Lys Val Leu Gln 
        515                 520                 525             


Ser Gln Lys Asp Ile Asn Leu Pro Gln Lys Glu Val Val Asp Asn Val 
    530                 535                 540                 


Val Gly Arg Lys Phe Glu Thr Met Asp Glu Phe Lys Ile Ala Leu Glu 
545                 550                 555                 560 


Glu Ile Cys Tyr Ile Arg Arg Glu Arg Leu Ser Ala Asn Ala Glu Ser 
                565                 570                 575     


Glu Leu Lys Ser Lys Phe Asn Ala Gln Ile Phe Asp Ile Thr Ser Leu 
            580                 585                 590         


Asp Leu Arg Asn Pro Val Asn Cys Ala Gly Lys Pro Glu Val Tyr His 
        595                 600                 605             


His Asn Asp Lys Arg His Thr Glu Ile Trp Lys Glu Phe Trp Ser Leu 
    610                 615                 620                 


Asp Asn Glu Arg Arg Asn Phe Asn Ile Arg Leu Asn Pro Glu Ile Thr 
625                 630                 635                 640 


Ile Thr Tyr Arg Lys Pro Lys Glu Ser Arg Ile Leu Lys Tyr Gly Lys 
                645                 650                 655     


Gly Thr Glu Lys Tyr Asn Ala Asp Met Lys Asn Arg Tyr Leu Tyr Pro 
            660                 665                 670         


Gln Tyr Thr Leu Leu Thr Thr Ile Ser Glu His Cys Asn Thr Pro Thr 
        675                 680                 685             


Lys Ile Leu Ser Phe Met Thr Asp Asn Glu Tyr Glu Glu Ser Ile Lys 
    690                 695                 700                 


Ala Phe Asn Ser Lys Leu Lys Lys Glu Asp Ile Lys Phe Ala Phe Gly 
705                 710                 715                 720 


Ile Asp Ser Gly Glu Thr Glu Leu Ser Thr Leu Gly Val Tyr Leu Pro 
                725                 730                 735     


Glu Phe Ser Ala Glu Ser Thr Glu Leu Lys Asp Ile Glu Lys Tyr Gly 
            740                 745                 750         


Phe Asn Val Leu Thr Ile Lys Asp Leu Asn Tyr Thr Glu Thr Asp Tyr 
        755                 760                 765             


Asn Gly Ser Asp Lys Lys Ile Val Lys Asn Pro Ser Tyr Phe Val Asp 
    770                 775                 780                 


Lys Ser Leu Tyr Met Arg Thr Phe Lys Lys Thr Glu Gln Glu Tyr Glu 
785                 790                 795                 800 


Lys Met Phe Ala Glu Gln Phe Glu Ala Lys Lys Arg Leu Ser Leu Asp 
                805                 810                 815     


Leu Ser Ala Ala Lys Val Ile Cys Gly His Ile Val Thr Asn Gly Gly 
            820                 825                 830         


Val Ser Glu His Phe Gly Leu Trp Leu Lys His Ala Gln Arg Thr Ile 
        835                 840                 845             


Phe Trp Met Asn Asp His Thr Glu Lys Lys Thr Ala Lys Asn Ile Lys 
    850                 855                 860                 


Leu Lys Asp Ser Ser Glu Leu Thr Tyr Asp Glu Arg Glu Lys Phe Ala 
865                 870                 875                 880 


Glu His Ile Ser Ser Asp Glu Lys Phe Lys Lys Leu Asp Val Glu Glu 
                885                 890                 895     


Lys Lys Arg Tyr Val Arg Trp Ile Phe Glu Asp Arg Glu Thr Leu Asn 
            900                 905                 910         


Phe Thr Glu Ala Glu Asn Lys Lys Phe Gly Gly Tyr Gln Lys Lys Lys 
        915                 920                 925             


Gly Asp Tyr Arg Leu Gly Ile Leu Phe Ala Ser Cys Phe Ile Gly Lys 
    930                 935                 940                 


Glu Leu Glu Ser Val Thr Gln Ile Leu Asp Cys Arg His Ile Phe Lys 
945                 950                 955                 960 


Lys Arg Glu Glu Phe Tyr Ser Leu Lys Ser Lys Glu Asp Ile Glu Ala 
                965                 970                 975     


Glu Ile Lys Arg Tyr Asn Thr Asp Tyr Thr Asn His Asn Ile Ser Thr 
            980                 985                 990         


Glu Gln Leu Asp Leu Lys Phe Val  Asn Val Lys Asn Ala  Leu Val Ala 
        995                 1000                 1005             


Asn Ala  Val Gly Val Ile Asp  Leu Leu Tyr Lys Gln  Tyr Lys Glu 
    1010                 1015                 1020             


Arg Leu  Gly Gly Glu Gly Leu  Ile Ala Lys Glu Gly  Phe Asp Thr 
    1025                 1030                 1035             


Lys Lys  Val Glu Glu Asp Met  Glu Lys Phe Ser Gly  Asn Ile Tyr 
    1040                 1045                 1050             


Arg Ile  Leu Glu Arg Lys Leu  Tyr Gln Lys Phe Gln  Asn Tyr Gly 
    1055                 1060                 1065             


Leu Val  Pro Pro Ile Lys Asn  Leu Met Ala Val Arg  Ala Asp Lys 
    1070                 1075                 1080             


Val Glu  Ile Ser Glu Ala Glu  Lys Ser Lys Ile Arg  Glu Asn Cys 
    1085                 1090                 1095             


Lys Ile  Ser Lys Ile Asp Pro  Glu Asn Glu Ile Ile  Lys Arg Asn 
    1100                 1105                 1110             


Lys Thr  Leu Ile Leu Arg Leu  Gly Ser Ile Ala Phe  Val Asn Asp 
    1115                 1120                 1125             


Ala Asp  Thr Ser Gln Glu Cys  Pro Ala Cys Gly Thr  Lys Ser Lys 
    1130                 1135                 1140             


Glu Lys  His Val Asp Asn Phe  Ile Cys Gly Cys Gly  Phe Asn Ser 
    1145                 1150                 1155             


Thr Gly  Ile Ile His Ser Asn  Asp Gly Val Ala Gly  Phe Asn Ile 
    1160                 1165                 1170             


Ala Lys  Arg Gly Phe Val Asn  Leu Met Glu His Glu  Leu Arg Ser 
    1175                 1180                 1185             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val 
    1190                 1195             


<210>  91
<211>  1206
<212>  PRT
<213>  ˹

<220>
<223>  Cas12j.12-NLSںϵ׵İ

<400>  91

Met Glu Lys Tyr Lys Leu Thr Lys Thr Ile Arg Phe Lys Leu Lys Pro 
1               5                   10                  15      


Lys Asp Ile Ser Ala Ile Lys Arg Asp Val Glu Ala Leu Glu Gln Gln 
            20                  25                  30          


Lys Phe Asp Leu Val Leu Phe Val Tyr Asn Leu His Asn Phe Ile Gly 
        35                  40                  45              


Lys Leu Lys Glu Tyr Leu Phe Phe Gln Lys Glu Lys Asp Glu Phe Val 
    50                  55                  60                  


Ile Lys Asp Lys Leu Thr Ile Lys Lys Thr Trp Leu Lys Gln Tyr Ala 
65                  70                  75                  80  


Lys Gln Glu Ile Ala Gly Leu Glu Leu Asn Arg Glu Gln Thr Leu Gly 
                85                  90                  95      


Asn Ile Lys Gly Val Ser Ala Arg Ile Glu Arg Ala Val Asp Asp Val 
            100                 105                 110         


Asn Lys Ile Tyr Val Glu Leu Ala Met Glu Ala Lys Leu Asn Glu Arg 
        115                 120                 125             


Ala Lys Lys Ala Lys Thr Glu Gln Leu Ile Lys Arg Leu Asp Thr Arg 
    130                 135                 140                 


Asn Ala Leu Pro Leu Leu Val Ser Leu Ile Glu Gln Ser Ser Asp Lys 
145                 150                 155                 160 


Tyr Glu Thr Gly Asn Leu Ser Ile Gln Leu Lys Arg Leu Gly Lys Arg 
                165                 170                 175     


Leu Gln Thr Gln Leu Leu Ser Gly Ile Lys Lys Tyr Leu Ala Glu Gln 
            180                 185                 190         


Ser Asn Gly Leu Pro Ile Ala Lys Ala Ser Phe Asn Tyr Tyr Ala Ile 
        195                 200                 205             


Asn Lys Lys Pro Val Asp Tyr Ile Asp Lys Ile Lys Gln Leu Gln Lys 
    210                 215                 220                 


Asp Leu Glu Ile Lys Lys Asn Arg Arg Ser Glu Glu Arg Tyr Asp Lys 
225                 230                 235                 240 


Lys Lys Arg Lys Asn Ile Lys Ile Phe Asn Asp Ser Lys Leu Trp Ile 
                245                 250                 255     


Lys Ile Lys Lys Asp Ile Glu Lys Glu Arg Gly Asn Lys Thr Leu Ile 
            260                 265                 270         


Leu Gly Tyr Ala Pro Met Ile Glu Pro Gly Asn Tyr Val Tyr Leu Arg 
        275                 280                 285             


Gln Ile Leu Lys Asn Ile Lys Leu Glu Gln Lys Asn Lys Phe Ser Lys 
    290                 295                 300                 


Leu Met Gln Ser Lys Ser Leu Thr Phe His Asp Leu Asn Asn Asn Asn 
305                 310                 315                 320 


Gln Leu Tyr Leu Phe Lys Asp Ile Leu Glu Gly Glu Phe Asn Lys Tyr 
                325                 330                 335     


Lys Gln Lys Thr Asn Glu Ile Glu Thr Lys Ala Glu Lys Arg Asn Gln 
            340                 345                 350         


Cys Asn Asn Asp Glu Leu Lys Arg Lys Leu Asn Ser Glu Leu Gln Gln 
        355                 360                 365             


Leu Arg Lys Asp Arg Gly Ser Leu Ile Asn Ala Ala Asp Gly Arg Pro 
    370                 375                 380                 


Lys Gly Arg Phe Lys Thr Tyr Lys Tyr Phe Ala Asn Phe Tyr Arg Asn 
385                 390                 395                 400 


Val Ala Gln Lys His Gly Arg Ile Leu Ser Thr Leu Lys Gly Ile Glu 
                405                 410                 415     


Lys Glu Met Val Glu Ser Gln Leu Leu Lys Tyr Trp Thr Ile Ile Thr 
            420                 425                 430         


Glu Glu Asn Asn Gln His Ser Leu Val Leu Ile Pro Lys Glu Arg Ala 
        435                 440                 445             


Gly Glu Tyr Lys Lys Asp Leu Glu Asn Ser Ile Pro Ser Asp Pro Ser 
    450                 455                 460                 


Ser Lys Ile Lys Val Tyr Trp Phe Glu Ser Phe Thr Leu Arg Ser Leu 
465                 470                 475                 480 


Arg Lys Leu Cys Phe Gly Tyr Val Asn Asn Asn Thr Gly Ser Asn Thr 
                485                 490                 495     


Phe Tyr Pro Glu Leu Lys Lys Ser Asp Glu Leu Arg Lys Tyr His Asp 
            500                 505                 510         


Glu Arg Gly Asn Phe Ile Lys Gly Glu Phe Tyr Phe Lys Gly Asp Glu 
        515                 520                 525             


Gln Lys Ile Ile Gln Phe Tyr Lys Asp Val Leu Arg Ser Asn Tyr Ala 
    530                 535                 540                 


Gln Lys Val Leu Lys Phe Pro Lys Gln Gln Val Lys Asp Glu Leu Ile 
545                 550                 555                 560 


Gly Arg Glu Phe Ser Ser Leu Asp Glu Phe Gln Ile Ala Leu Glu Lys 
                565                 570                 575     


Ile Cys Tyr Gln Arg His Val Val Cys Ser Gln Lys Val Val Asp Ala 
            580                 585                 590         


Leu Ser Arg Tyr Asn Ala Gln Ile Phe Leu Ile Thr Ser Leu Asp Leu 
        595                 600                 605             


Gly Asn Pro Ala Asn Cys Val Asp Lys Pro Lys Gln Phe Ser His Phe 
    610                 615                 620                 


Asp Lys Lys His Thr Arg Ile Trp Lys Glu Phe Trp Ser Ser Lys Asn 
625                 630                 635                 640 


Glu Thr Ala Asn Phe Asp Ile Arg Leu Asn Pro Glu Ile Val Ile Thr 
                645                 650                 655     


Tyr Arg Gln Pro Lys Gln Ser Arg Ile Lys Lys Tyr Gly Pro Glu Ser 
            660                 665                 670         


Thr Arg Tyr Asp Asp Arg Lys His Asn Arg Tyr Leu Tyr Pro Gln Phe 
        675                 680                 685             


Thr Leu Ile Thr Thr Ile Ser Glu Tyr Ser Asn Ala Pro Thr Lys Ala 
    690                 695                 700                 


Leu Ser Phe Leu Thr Asp Glu Glu Phe Lys Gly Ala Val Asp Glu Phe 
705                 710                 715                 720 


Asn Lys Lys Phe Lys Lys Glu Asn Ile Arg Phe Ser Leu Gly Ile Asp 
                725                 730                 735     


Asn Gly Glu Thr Glu Leu Ser Thr Leu Gly Val Tyr Leu Pro Val Phe 
            740                 745                 750         


Lys Lys Asp Ser Asn Glu Lys Val Val Ala Glu Leu Lys Lys Val Asn 
        755                 760                 765             


Lys Tyr Gly Phe Asn Phe Leu Thr Ile Lys Asp Leu Ser His Val Glu 
    770                 775                 780                 


Lys Asp Lys Asn Gly Arg Val Arg Lys Ile Ile Gln Asn Pro Ser Tyr 
785                 790                 795                 800 


Phe Leu Ser Lys Glu Gln Tyr Met Arg Thr Phe Gly Arg Thr Glu Gln 
                805                 810                 815     


Glu Tyr Asn Asn Met Phe Ala Glu Gln Phe Glu Glu Lys Ala Phe Leu 
            820                 825                 830         


Ser Leu Asp Leu Thr Thr Ala Lys Val Ile Asn Gly His Ile Val Thr 
        835                 840                 845             


Asn Gly Asp Val Pro Thr Phe Leu Asn Leu Trp Met Arg His Ala Gln 
    850                 855                 860                 


Arg Asp Ile Trp Asp Met Asn Asp His Thr Lys Glu Lys Thr Ala Lys 
865                 870                 875                 880 


Lys Ile Val Ile Lys Asn Asn Asp Glu Leu Thr Asp Ala Glu Lys Val 
                885                 890                 895     


Lys Phe Val Glu Tyr Ile Ser Asp Glu Thr Asn Tyr Ala Lys Leu Asn 
            900                 905                 910         


Phe Asn Glu Lys Lys Arg Tyr Val Leu Trp Ile Phe Glu Asn Arg Lys 
        915                 920                 925             


Asn Ile Asn Phe Thr Asp Ala Glu Lys Lys Lys Phe Glu Pro Cys Gln 
    930                 935                 940                 


Lys Arg Lys Gly Asn Phe Ser Lys Asp Ile Leu Phe Ala Val Cys Tyr 
945                 950                 955                 960 


Ile Gly Ser Glu Ile His Ser Val Thr Asn Ile Phe Asp Val Arg Asn 
                965                 970                 975     


Ile Phe Lys Met Arg Lys Asp Phe Tyr Val Leu Lys Ser Glu Met Glu 
            980                 985                 990         


Ile Lys Lys Glu Ile Glu Ser Tyr  Asn Thr Thr Ala Gly  Ile Gln Glu 
        995                 1000                 1005             


Ile Ser  Asn Glu Glu Leu Asp  Leu Lys Ile Asn Arg  Leu Lys Gln 
    1010                 1015                 1020             


Ala Val  Val Ala Asn Ala Val  Gly Val Ile Asp Tyr  Leu Tyr Ile 
    1025                 1030                 1035             


Tyr Tyr  Lys Lys Lys Thr Gly  Gly Glu Gly Leu Ile  Ile Lys Glu 
    1040                 1045                 1050             


Gly Phe  Asp Thr Lys Lys Val  Ala Lys Ala Leu Glu  Lys Phe Ser 
    1055                 1060                 1065             


Gly Asn  Ile Tyr Arg Ile Leu  Glu Arg Lys Leu Tyr  Gln Lys Phe 
    1070                 1075                 1080             


Gln Asn  Tyr Gly Leu Val Pro  Pro Ile Lys Ser Leu  Met Ala Val 
    1085                 1090                 1095             


Arg Glu  Glu Gly Ile Glu Asn  Asn Lys Asp Ala Ile  Leu Arg Leu 
    1100                 1105                 1110             


Gly Asn  Val Gly Phe Ile Asp  Pro Thr Gly Thr Ser  Gln Gln Cys 
    1115                 1120                 1125             


Pro Val  Cys Ser Lys Gly Lys  Leu Asn His Thr Thr  Lys Cys Ser 
    1130                 1135                 1140             


Lys Asn  Cys Gly Phe Asn Ser  Lys Asn Ile Met His  Ser Asn Asp 
    1145                 1150                 1155             


Gly Ile  Ala Gly Tyr Asn Ile  Ala Lys Arg Gly Phe  Glu Asn Phe 
    1160                 1165                 1170             


Ile Ser  Gln Lys Lys Gly Tyr  Asp Val Ile Asn Asn  Gly Thr Lys 
    1175                 1180                 1185             


Tyr Asn  Asn Leu Lys Ser Gln  Ser Arg Ala Asp Pro  Lys Lys Lys 
    1190                 1195                 1200             


Arg Lys  Val 
    1205     


<210>  92
<211>  3069
<212>  DNA
<213>  ˹

<220>
<223>  Cas12g.1ϵͳеĺ

<400>  92
tttacacttt atgcttccgg ctcgtatgtt aggaggtctt tatcatgtta tataccatga       60

acgtaaaaac tataaaacta aaggtagacg ctacaaaaga agtagaatca agactgacaa      120

aaatgttgtt agtacacaat aacattggtc gtgaaattat taattttttg attttatgta      180

gtggaaatga taatatcaga aaaaccaaat ttgatgagtt tggaaattca tacgatgaat      240

tttgtaattt aaaattagat caatttaatt tatacgatag attgacagaa attcacgatg      300

aagtaacact tgaggatttt caaaaaacat taaatgatat ttacgatctg gtattaaatt      360

caaagtcatt ttctaatgta tcttctacaa tattcaataa aaataagaaa gttaattttg      420

atgaaaccaa aaaaggagat ttgtcacgta aatgtttgat gaatgctcga gattggggtg      480

ttttaccatt aatttctgtt gatgatgata ttgttacatg tggaacttta aagggaatac      540

tatcggaatg tcaatctcgt atattatctt ggaatgaatg taatctttct acgaaagaaa      600

catatagtga aaagaaaagt gaatatcaat ctattttaga tgattctatg accaaagatg      660

ctgatgttac tactgctatg atacaattca tggatgatgt ttcaaatgtg tatggttcaa      720

ataatgaaaa tcaattgaaa tggtttaaca atcgatttct aacatatgtt agaaataaaa      780

ttagaccatt tttattgaca aactcgccaa ttgacaattt tgaacaatcg gatacttctt      840

ataattgttc tattgaaatc gttagaattt taagtaaata tgaaatttta tggaaagatg      900

aagtttctgt taatagatat aagaaaacat gtgacgatgg aataaacatt gaaaaatata      960

gatatttggt acatgcaaaa tctgactttt tgaggtataa ggaaacagca tcttttaaag     1020

aaattcatgc tgtaaaaagt ccaatatcat tgtgttttgg aaacaattat caaccatttt     1080

cattgagtga tgttggtgac agacataata ttaactttgg ttataaattt ggtaaattag     1140

gaaaacagcg aaaggaatgt tcatttaatt taaattatag aaggaaaaaa gtaaaatatg     1200

caaacactcc cgttcggtct gacgaaaaca agtgttattt agataatctt gaaatcgaag     1260

atgcaaagaa tggttcttac aaactttcat atatggttaa taaaaaatat aaacgtgagt     1320

cgtttatcaa agaacctaaa atgaaaatgt ataatggtaa attgtatatg tattttccaa     1380

tgtcaaatga atttgaagaa gacagagatt catttgcgtt actaacttat tttagcagat     1440

catccaactc aaaatctcaa attgatgaag ctagtaacat attgcaaaat agaaagattc     1500

gtgtgtgtgg tgtggatttg ggaataaacc caacgtttgc tttatctgta ttagagtata     1560

gtgataacaa gataaccgac actaacatcg gcatgaagca tgaagggtct tataataact     1620

tcagtgaaat cagaaaacaa ataaatgatg taactgacat gatttcctat ttaaagtcaa     1680

aatatgataa ttgtgaaaaa gactattctt ctaaaataga cgatcatatc aaaagtagat     1740

tgaatgaaga aatttcaaat ttttgtgatt tggtttctta taaaagaaat aaaaatacga     1800

ttatacgaaa agaaataaag aatgtagaaa aggaaattaa taagattaaa aattgtcgcc     1860

gtcacactct taaaaaagat ttaactgaaa attttggatg ggtttctgca ttaaatgagt     1920

ttatatcatt aaaacattca ttcaatgata tgggagaatc gtttgattca aaaacaaatc     1980

caagttatag ttattttgaa aagtggaaac gttatattga caatataaag gatgattcgc     2040

tgaaaacagt ttcacgggaa attttaaatt tctgtataga aaactcagtt gatttcattg     2100

cgttggaaga cttacaaact ttcgctccgt cggatgatag aacgaaaagt cacaataaac     2160

taactcagtt atggtgtttt ggaaaattaa aaaaatgttt agaagatatt gcttctatgt     2220

atggtattca tgtgtattca agcacagacc ctagaaacac atctgacacg cattttgaat     2280

ccaaaaattt tggatatcgt gatgagtcaa ataaacataa tttatgggtt aatgtagatg     2340

gtgaatatac tgtggttgat tccgatatta atgcttctaa aaatattgca aatcggtttt     2400

taacgcatca taaagattta aaacaattgc caatgattgg tgatgggact ttatttaaaa     2460

ttgatagttc ttcaaaacga aataaatctt ttgcggtaaa attaaatata cacaaaaacg     2520

tatacgagtt aatagatggt gaatttgtaa aatcaaacaa aaaaccaaac ggaacttcac     2580

gtaaacaaac tgcttatata catggtgata tgtttatcga ttcaatatca cataaaaata     2640

aaaaaatgtt cttgagagaa aatctaataa gaaacgggtt tatatcaaaa taaaaataaa     2700

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     2760

tctcctgagt aggacaaatt tgacagctag ctcagtccta ggtataatgc tagcgctgag     2820

tctaatatga tagtaaaata ttatatagtt tagacggtat aacaacttcg acgagctcta     2880

cagtctaata tgatagtaaa atattatata gtttagacgt gtcagaggtg agtgttaact     2940

atgtgaagtc taatatgata gtaaaatatt atatagttta gacaaataaa acgaaaggct     3000

cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt     3060

aggacaaat                                                             3069


<210>  93
<211>  35
<212>  DNA
<213>  ˹

<220>
<223>  PAMĿ


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n = agct

<400>  93
nnnnnnnngg tataacaact tcgacgagct ctaca                                  35


<210>  94
<211>  3093
<212>  DNA
<213>  ˹

<220>
<223>  Cas12h.1ϵͳеĺ

<400>  94
tttacacttt atgcttccgg ctcgtatgtt aggaggtctt tatcatggcc ctgatccaga       60

gggccggcgt gctgaagacc aagtccgact tcccgaaggt gatcaaggac tggcacgact      120

ccctgctggc cgactacagg aagttcttcc cgatcatctt ctcctggtgc ccggagtacg      180

gctacaccac catccaggac aacaagccgg tgttcgtgtc cccggaggag aggatggagt      240

ccatcaggaa ggaggccaag gagcacctga acgaggtgct ggccttcggc aagatgatcg      300

gctccaaggg cgtgggcggc tcctcctcct acgccatctt ctacaagcac cacaagaaca      360

acgagaacgg cgcctacacc ccgtccaggg ccaagttcat gaaggagggc atccacaaca      420

ggagggtgga gctggtggac gtgctgatgc tgaacgccat cccggacgag gagtgggtga      480

agatcgccca ggaggtggtg ggctactccg aggagaggct gaagctgtac tggaacaagt      540

tcatcgccaa gagggtggtg tcccacgaca ggaagctggg caagatcgtg agggagaagt      600

acctggagcc gaagggcctg gtgtgcgccc agccggagaa ctccacctac tgcagggtgc      660

tgaccgagat catcaagagg cagctgcact cccagatcga gaagtccaag ttccacgagg      720

aggagctgaa gtccatcgag aagaccgtgt ccgagttcga ctccccgctg ctggacttca      780

tctgccagta cgccgaggag ctgaaccaga tcaactccgg cctgtccaag tacgtgatca      840

agaacgccgt gaaggaggtg atctccccgc cggagaagca gtccgagatc tacgtgcagt      900

cccaggtgct gtcccaggag aagtacaagc cgctggtgaa cgccaccatc aaggagatcc      960

tgtccggcta cgagcagtgg aaggtgaagt ccaggtacga gaacaggctg aagaacagga     1020

agtacgtgct gtacccgaag ctgtccgcca actacaagat cccgatcggc cagaactccc     1080

tgggcaagtt caagatcaac gtgtccgaga acggcgagat cgtgatcagg ctgaacgaca     1140

tggccgacgt ggtgtgcatg ccgtccaagt acttcttcaa cctgaagtcc tccccggtgg     1200

tggacaagaa gaagcagctg gtgggctacc agatctcctt caaccacaac tccaggagga     1260

aggagccgac cgagaagccg gacttcaacg gcatcgtgaa ggagatcggc ctgcagctga     1320

aggacgacgg caggttctac atcaccctgc cgtactgcat ggagtactcc aacgacaact     1380

tcgacctgat caggccgctg ctgacctcct ccccgaccga ggaccagatc aagaagatgc     1440

cgtccgagtt caacgtggtg ggcttcgacc tgaacctgtc catgccgctg ccgatcacca     1500

gggccatcgt gggcaagtcc gtgaagggcg agatcaacgt ggagtacctg ggccaggcca     1560

aggtgatcga gtccacccac ctgatctacg acaacaacag gtgcaaggtg ctgatcgcct     1620

acaagaggca gtgcgacctg atcaagaggg ccatcaggga gtggaagatc tgcaagggca     1680

agaacatcga catctccgag aagacctacg agtggctgga gtcccacacc aagaggtgga     1740

acccgtccag gcagccggag tccatgcagg acaggttctc cgtgtccaag atgaggatcc     1800

agatcctggt gaacaaggcc aagtccagga tcgccaagta caacgacaac tcctggaaga     1860

ccggccacgg caacgagtcc gagctgatca ggctgatcga cgccgacgac gcctacaact     1920

ccctggtgtc cacctacaac aggatccacc tgaagtccaa ccagttcatc tacgccctgc     1980

cgtccaagaa caactccagg tccaacaaga aggagtactg cctgaggagg atcgccgcca     2040

agatcgccag gtactgccac ctgcacaacg tgaacatctg catcggcgag aacctgtcct     2100

tccagcagga ctccgacaac atctccaagg acaactccct ggtgaggctg ttctcctcca     2160

agtccatcgc caactacatg aagctggcca tggagaagtt cggcatcgcc ttcatcgact     2220

ccgccgaccc gtccggcacc tccaagaccg acccggtgac cggcaacatc ggctacagga     2280

acaagttcga caagaggaag ctgcacgtga tcaggaacgg caactggggc tgggtggact     2340

ccgacatcgc cgcctccctg aacatcctga tcaggggcat caacaggtcc atcgtgccgt     2400

acaagttctt cgtgggcaag aagaagcagg agtccaagag gctgaaccac ttcctgaaca     2460

agatcttcgg caccaccaag gtgttcttct acgaggacca gttcggcttc gccaacccgt     2520

ccctgtccaa gaaggagggc gagaacctga tcgccaacca gtacctgtac tacagggagg     2580

gcaagttcgt gacccagaag atccacaggc agatcgagga cgacttcaag aagatcgact     2640

tctccaacac cccggaggtg aacctgatcc cgtccggcgt gaagctgaag aacttccagt     2700

tcgagtgaaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttatctgttg     2760

tttgtcggtg aacgctctcc tgagtaggac aaatttgaca gctagctcag tcctaggtat     2820

aatgctagcg ctgaatgtgc tgcatggcaa cgctagatgc catgtgttcg caacggtata     2880

acaacttcga cgagctctac aatgtgctgc atggcaacgc tagatgccat gtgttcgcaa     2940

ctatttcagc ccaattgggt ttatatcatg tgctgcatgg caacgctaga tgccatgtgt     3000

tcgcaacaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgt     3060

ttgtcggtga acgctctcct gagtaggaca aat                                  3093


<210>  95
<211>  2682
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 74ʾںϵ׵ı

<400>  95
atgctgtaca ccatgaacgt gaagaccatc aagctgaagg tggacgccac caaggaggtg       60

gagtccaggc tgaccaagat gctgctggtg cacaacaaca tcggcaggga gatcatcaac      120

ttcctgatcc tgtgctccgg caacgacaac atcaggaaga ccaagttcga cgagttcggc      180

aactcctacg acgagttctg caacctgaag ctggaccagt tcaacctgta cgacaggctg      240

accgagatcc acgacgaggt gaccctggag gacttccaga agaccctgaa cgacatctac      300

gacctggtgc tgaactccaa gtccttctcc aacgtgtcct ccaccatctt caacaagaac      360

aagaaggtga acttcgacga gaccaagaag ggcgacctgt ccaggaagtg cctgatgaac      420

gccagggact ggggcgtgct gccgctgatc tccgtggacg acgacatcgt gacctgcggc      480

accctgaagg gcatcctgtc cgagtgccag tccaggatcc tgtcctggaa cgagtgcaac      540

ctgtccacca aggagaccta ctccgagaag aagtccgagt accagtccat cctggacgac      600

tccatgacca aggacgccga cgtgaccacc gccatgatcc agttcatgga cgacgtgtcc      660

aacgtgtacg gctccaacaa cgagaaccag ctgaagtggt tcaacaacag gttcctgacc      720

tacgtgagga acaagatcag gccgttcctg ctgaccaact ccccgatcga caacttcgag      780

cagtccgaca cctcctacaa ctgctccatc gagatcgtga ggatcctgtc caagtacgag      840

atcctgtgga aggacgaggt gtccgtgaac aggtacaaga agacctgcga cgacggcatc      900

aacatcgaga agtacaggta cctggtgcac gccaagtccg acttcctgag gtacaaggag      960

accgcctcct tcaaggagat ccacgccgtg aagtccccga tctccctgtg cttcggcaac     1020

aactaccagc cgttctccct gtccgacgtg ggcgacaggc acaacatcaa cttcggctac     1080

aagttcggca agctgggcaa gcagaggaag gagtgctcct tcaacctgaa ctacaggagg     1140

aagaaggtga agtacgccaa caccccggtg aggtccgacg agaacaagtg ctacctggac     1200

aacctggaga tcgaggacgc caagaacggc tcctacaagc tgtcctacat ggtgaacaag     1260

aagtacaaga gggagtcctt catcaaggag ccgaagatga agatgtacaa cggcaagctg     1320

tacatgtact tcccgatgtc caacgagttc gaggaggaca gggactcctt cgccctgctg     1380

acctacttct ccaggtcctc caactccaag tcccagatcg acgaggcctc caacatcctg     1440

cagaacagga agatcagggt gtgcggcgtg gacctgggca tcaacccgac cttcgccctg     1500

tccgtgctgg agtactccga caacaagatc accgacacca acatcggcat gaagcacgag     1560

ggctcctaca acaacttctc cgagatcagg aagcagatca acgacgtgac cgacatgatc     1620

tcctacctga agtccaagta cgacaactgc gagaaggact actcctccaa gatcgacgac     1680

cacatcaagt ccaggctgaa cgaggagatc tccaacttct gcgacctggt gtcctacaag     1740

aggaacaaga acaccatcat caggaaggag atcaagaacg tggagaagga gatcaacaag     1800

atcaagaact gcaggaggca caccctgaag aaggacctga ccgagaactt cggctgggtg     1860

tccgccctga acgagttcat ctccctgaag cactccttca acgacatggg cgagtccttc     1920

gactccaaga ccaacccgtc ctactcctac ttcgagaagt ggaagaggta catcgacaac     1980

atcaaggacg actccctgaa gaccgtgtcc agggagatcc tgaacttctg catcgagaac     2040

tccgtggact tcatcgccct ggaggacctg cagaccttcg ccccgtccga cgacaggacc     2100

aagtcccaca acaagctgac ccagctgtgg tgcttcggca agctgaagaa gtgcctggag     2160

gacatcgcct ccatgtacgg catccacgtg tactcctcca ccgacccgag gaacacctcc     2220

gacacccact tcgagtccaa gaacttcggc tacagggacg agtccaacaa gcacaacctg     2280

tgggtgaacg tggacggcga gtacaccgtg gtggactccg acatcaacgc ctccaagaac     2340

atcgccaaca ggttcctgac ccaccacaag gacctgaagc agctgccgat gatcggcgac     2400

ggcaccctgt tcaagatcga ctcctcctcc aagaggaaca agtccttcgc cgtgaagctg     2460

aacatccaca agaacgtgta cgagctgatc gacggcgagt tcgtgaagtc caacaagaag     2520

ccgaacggca cctccaggaa gcagaccgcc tacatccacg gcgacatgtt catcgactcc     2580

atctcccaca agaacaagaa gatgttcctg agggagaacc tgatcaggaa cggcttcatc     2640

tccaagtcca gggccgaccc gaagaagaag aggaaggtgt ga                        2682


<210>  96
<211>  2841
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 75ʾںϵ׵ı

<400>  96
atgaacaaga ccgacaccca gaacaacgag cagatcaaca agccgaccca gctgctgaac       60

aacaaggaca tcgagctgac cgtgaagacc gtgaagtccg ccaccgtgaa ggtggacaac      120

aactccaaga aggagctgtt cggcctgttc aactacttca cctccgtggc ctccggcatc      180

aaggacaagg tgtacaacct gcagtccgac gagaagaccg ccccgatctt caacgactac      240

gtgaagcagc cgcagagggg caggtccgcc gccaccaccc tgttcaccaa gctggacgcc      300

gagaagacct acacctccca gcactccttc ccgggcaagt ggagggactc cggcatcttc      360

ccgctgtaca acaaggagtc cgagaagtac gacctgtcca cccacggcta ccactactcc      420

gccaacgccg agatccacac ccagctggac tcccacgacg agtgcaacaa ggagtgcgag      480

aaggagtacg ccgccctgag ggacgaggtg aacaactaca agtacgagtt caccctgcag      540

ttcaaggccg agaacgccga gaagttctac aacttcgtgg agaagctgac cctgatgggc      600

tggaggtacg acgccacctt caggtccttc ttcgagctgc acatgcaccc gaagctgaag      660

accggcgaga ccacctacag ggccacctac aagctgccgt ccggcaagtc caagaggtac      720

tccttcttca gggacgacat cgccgacgag atcgccaaga acccggagtt ctggccgatg      780

ctggagtcct ccaacgccat ctcctggatc aactccaaca acctgctgtc caggaagaag      840

gacaaggcca actactcctc cacctccctg atcaagtccc agatcaggct gtacctgggc      900

aacaacggcg tgccgttcac cgccagggag cacgacggca ggatctactt ctccttcagg      960

ctgccggcca tcaacggcga gaagggcagg atggtggaga tcccgtgctc ctacaagaag     1020

gtgttcaacg gcaaggccag gaagtcctgc tacctgggcg gcctgaccat cgagaagacc     1080

gacgccggca agcacatctt caagtactcc gtgaacaaca agaagccgca ggtggccgag     1140

ctgaacgagt gcttcctgag gctggtggtg aggaacaggg agtacttcaa caacgtggtg     1200

gccggcaaga tcaccgacat caacaccgac cacttcgact tctacgtgga cctgccgctg     1260

aacgtgaagg aggacccgat ccacgacctg tcctccaccg aggtgttcgg caagaacggc     1320

ctgaggtcct actactcctc cgcctacccg gagatcaaga acctgggctc ccagatcgag     1380

accggcaaga acctgacctg cccgatcacc aagacccaca acatcatggg catcgacctg     1440

ggccagagga acccgttcgc ctactgcatc aaggacaaca ccggcaagct gatcgcccag     1500

ggccacatgg acggctccaa gaacgagacc tacaagaagt acatcaactt cggcaaggag     1560

tccacctccg tgtcccacct gatcaaggag accaggtcct acctgcacgg cgacccggag     1620

gccatctcca aggagctgta caacgaggtg gccggcttct gcaacaaccc ggtgtcctac     1680

gaggagtacc tgaagtacct ggactccaag aagttcctga tcaacaagga ggacctgtcc     1740

aagaacgcca tgcacctgct gaggcagaag gaccacaact ggatcggcag ggactggctg     1800

tggtacatct ccaagcagta caagaagcac aacgagaaca ggatgcagga cgccgactgg     1860

aggcagaccc tgtactggat cgactccctg tacaggtaca tcgacgtgat gaagtccttc     1920

cacaacttcg gctccttcta cgacaagaac ctgaagaaga aggtgaacgg caccgtggtg     1980

ggcttctgca agaccgtgca cgaccagatc aacaacaaca acgacgacat gttcaagaag     2040

ttcaccaacg agctgatgtc cgtgatcagg gagcacaagg tgtccgtggt ggccctggag     2100

aagatggact ccatgctggg cgacaagtcc aggcacacct tcgagaacag gaactacaac     2160

ctgtggccgg tgggccagct gaagaccttc atggagggca agctggagtc cttcaacgtg     2220

gccctgatcg agatcgacga gaggaacacc tcccaggtgt gcaaggagaa ctggtcctac     2280

agggaggccg acgacctgta ctacgtgacc gacggcgagt cccacaaggt gcacgccgac     2340

gagaacgccg ccaacaacat cgtggacagg tgcatctcca ggcacaccaa catgttctcc     2400

ctgcacatgg tgaacccgaa ggacgactac tacgtgccga cctgcatctg ggacaccacc     2460

gaggagtccg gcaagagggt gaggggcttc ctgaccaagc tgtacaagaa ctccgacgtg     2520

gtgttcacca agaagggcga caagctggtg aagtccaaga cctccgtgaa ggagctgaag     2580

aagctggtgg gcaagaccaa ggagaagagg ggccagtact ggtacaggtt cgagggcaag     2640

tcctggatca acgaggccga cagggacacc atcatcctga acgccaagaa gatctccagg     2700

gagagggaca acggcgagca gtccaccgac accaggtccc agaacgtgac cgtgtccgtg     2760

ctggacgtgt gcgagaccgc cgagaagaag aagctggtgc tggtgtccag ggccgacccg     2820

aagaagaaga ggaaggtgtg a                                               2841


<210>  97
<211>  2697
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 76ʾںϵ׵ı

<400>  97
atggccctga tccagagggc cggcgtgctg aagaccaagt ccgacttccc gaaggtgatc       60

aaggactggc acgactccct gctggccgac tacaggaagt tcttcccgat catcttctcc      120

tggtgcccgg agtacggcta caccaccatc caggacaaca agccggtgtt cgtgtccccg      180

gaggagagga tggagtccat caggaaggag gccaaggagc acctgaacga ggtgctggcc      240

ttcggcaaga tgatcggctc caagggcgtg ggcggctcct cctcctacgc catcttctac      300

aagcaccaca agaacaacga gaacggcgcc tacaccccgt ccagggccaa gttcatgaag      360

gagggcatcc acaacaggag ggtggagctg gtggacgtgc tgatgctgaa cgccatcccg      420

gacgaggagt gggtgaagat cgcccaggag gtggtgggct actccgagga gaggctgaag      480

ctgtactgga acaagttcat cgccaagagg gtggtgtccc acgacaggaa gctgggcaag      540

atcgtgaggg agaagtacct ggagccgaag ggcctggtgt gcgcccagcc ggagaactcc      600

acctactgca gggtgctgac cgagatcatc aagaggcagc tgcactccca gatcgagaag      660

tccaagttcc acgaggagga gctgaagtcc atcgagaaga ccgtgtccga gttcgactcc      720

ccgctgctgg acttcatctg ccagtacgcc gaggagctga accagatcaa ctccggcctg      780

tccaagtacg tgatcaagaa cgccgtgaag gaggtgatct ccccgccgga gaagcagtcc      840

gagatctacg tgcagtccca ggtgctgtcc caggagaagt acaagccgct ggtgaacgcc      900

accatcaagg agatcctgtc cggctacgag cagtggaagg tgaagtccag gtacgagaac      960

aggctgaaga acaggaagta cgtgctgtac ccgaagctgt ccgccaacta caagatcccg     1020

atcggccaga actccctggg caagttcaag atcaacgtgt ccgagaacgg cgagatcgtg     1080

atcaggctga acgacatggc cgacgtggtg tgcatgccgt ccaagtactt cttcaacctg     1140

aagtcctccc cggtggtgga caagaagaag cagctggtgg gctaccagat ctccttcaac     1200

cacaactcca ggaggaagga gccgaccgag aagccggact tcaacggcat cgtgaaggag     1260

atcggcctgc agctgaagga cgacggcagg ttctacatca ccctgccgta ctgcatggag     1320

tactccaacg acaacttcga cctgatcagg ccgctgctga cctcctcccc gaccgaggac     1380

cagatcaaga agatgccgtc cgagttcaac gtggtgggct tcgacctgaa cctgtccatg     1440

ccgctgccga tcaccagggc catcgtgggc aagtccgtga agggcgagat caacgtggag     1500

tacctgggcc aggccaaggt gatcgagtcc acccacctga tctacgacaa caacaggtgc     1560

aaggtgctga tcgcctacaa gaggcagtgc gacctgatca agagggccat cagggagtgg     1620

aagatctgca agggcaagaa catcgacatc tccgagaaga cctacgagtg gctggagtcc     1680

cacaccaaga ggtggaaccc gtccaggcag ccggagtcca tgcaggacag gttctccgtg     1740

tccaagatga ggatccagat cctggtgaac aaggccaagt ccaggatcgc caagtacaac     1800

gacaactcct ggaagaccgg ccacggcaac gagtccgagc tgatcaggct gatcgacgcc     1860

gacgacgcct acaactccct ggtgtccacc tacaacagga tccacctgaa gtccaaccag     1920

ttcatctacg ccctgccgtc caagaacaac tccaggtcca acaagaagga gtactgcctg     1980

aggaggatcg ccgccaagat cgccaggtac tgccacctgc acaacgtgaa catctgcatc     2040

ggcgagaacc tgtccttcca gcaggactcc gacaacatct ccaaggacaa ctccctggtg     2100

aggctgttct cctccaagtc catcgccaac tacatgaagc tggccatgga gaagttcggc     2160

atcgccttca tcgactccgc cgacccgtcc ggcacctcca agaccgaccc ggtgaccggc     2220

aacatcggct acaggaacaa gttcgacaag aggaagctgc acgtgatcag gaacggcaac     2280

tggggctggg tggactccga catcgccgcc tccctgaaca tcctgatcag gggcatcaac     2340

aggtccatcg tgccgtacaa gttcttcgtg ggcaagaaga agcaggagtc caagaggctg     2400

aaccacttcc tgaacaagat cttcggcacc accaaggtgt tcttctacga ggaccagttc     2460

ggcttcgcca acccgtccct gtccaagaag gagggcgaga acctgatcgc caaccagtac     2520

ctgtactaca gggagggcaa gttcgtgacc cagaagatcc acaggcagat cgaggacgac     2580

ttcaagaaga tcgacttctc caacaccccg gaggtgaacc tgatcccgtc cggcgtgaag     2640

ctgaagaact tccagttcga gtccagggcc gacccgaaga agaagaggaa ggtgtga        2697


<210>  98
<211>  2799
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 77ʾںϵ׵ı

<400>  98
atggccacca ggtccttcat caggaccggc aacctgaagg ccaagaacac cgccgaggag       60

gtgatgcagt ggtacgccga cctgcagtcc gactacaggt ccttcctgaa cctgttcttc      120

ggctggatgg ccatcggcta cggcaccaac gccgaggacg aggtgttcta cacctccaag      180

gaggagtccg agaggctgag gtccctgacc atcggcgacg ccaagaagga gcagctggcc      240

gtgtccttca tcgagctgct gctgaagggc ggcgagaacg cctcctcctg ctacaacgtg      300

ttctacagga actacaagtc cctgggcaag gccaagctga cccagaagaa gaacgacttc      360

ctgtccgccc tgccgctgct ggacgagaac aagatcaagg agtacttcaa gaccgacgag      420

cagctgtccc agatctgcat cgaggagtgg ctggagtacg gcgtgaagaa cctgccgctg      480

ccggagatct gggccgaggt gtccccgagg ctggcctcca tcgagaggtc cctgggcgtg      540

gacctgaggc tggccttcgg cctgtcctgc atcaggtcca gggactgcaa ctactgcagg      600

atcctgatcg agatggtggg cagggacctg aggtccatct tcgagaagta caacaaccac      660

ctgctggaga ccgagaagat caagctgtcc atgaacgaca agcagggccc ggtgtacgac      720

tccatctgct gcttcgccgc cgagctggag tccaagaact ccggcctgac caagtacgtg      780

ctgaccaagg gcatcgacca cgtgaagaag ggcaccggcg agaagaccga catcaggctg      840

gccgtgaagg agctgaagaa gaacaagtac aggatcctga tcgagtcctc ctactccgag      900

atcatgtccg cctactcctg ctggaggacc aagaagcagc tggagaagag gaagctgtac      960

ccgtgcttcg acccgaacag gaacgactac aaggtgccgg tgggccaggg ctccctgggc     1020

aacttcaccg tgtccgtgga ggactccggc gacgtgctga tcgagatcgt gggcgtgggc     1080

gtgatcaggt gcgccgcctc ctgctacttc tccggcatcg tgttcgacga gatcaggaac     1140

aagaacggca ggaccggcta ctccctgaac ttctgccaca agtccatctc caagggcaag     1200

aaggccgtga aggccgcctc ccacaccggc gacaagatct ccggcgtgct gaaggagatc     1260

ggcctgagga acaccgactc cggcttcttc gtgtccctgc cgtactccat ccaccacgac     1320

gagaagaact tcaagatcgc cgagttcttc atgtccgcct gcccgaagaa ggagaacgtg     1380

gagaacctgc cggacaagat cgtggtgggc gccatcgacc tgaacgtgtc caacccggtg     1440

gccgccgtga aggccgtggt gtacagggac gacaagtccg gccagctgaa cgccctggac     1500

tacggctccg gcaacctgat caagaagccg ttcatgctgg tggccaacgg cccgaggatc     1560

aagaacctga tcgagatcag ggacgacgcc aggagggtga tcggcgccat cagggagttc     1620

aaggtgtcca acgccgtgaa ggagcacgtg ggcgaggaca ccagggactt cctgatcctg     1680

tgcggcgaca ccaagtcctc ctccaccagg tacctgatcc agtcctgggt gaagaagatc     1740

aactccaggc tgaggaagat caagttcgag atgaggtccg gcggctacag ggactgcgcc     1800

gacaacatca ggctgatcga ggccatggac cagtgcgcct ccatggccga gtcctacaac     1860

aggatccacc tgaagtccgg cgagaagctg gtgaaggtgg ccaagttcga caagtccagg     1920

gccaacttca ggaacttcgt gctgaggcag ctggcctcca agatcgccaa cgagatgaag     1980

gactgcaacg tggtgttcgg cgaggacctg gacttcatct tcgactccga caagaacaac     2040

aacgccctgc tgaggctgtt ctccgccgcc accctgctga agtacatcat cgaggccctg     2100

gagaagatcg gcgtgggctt cgtgaaggtg gccaagaacg gcacctccca gtccgacccg     2160

gtgacctcca acccgggctg gagggacgac aagaacaagt ccaggctgta cgtggtgagg     2220

gacaagcagc tgggctggat cgactccgac ctggccgcca ccatgaacat cctgatccag     2280

ggcctgaacc actccgtgtg cccgtacaag ttctacgtga aggagtacga gaacaagccg     2340

aactccaccc aggactccat caacgccatc aagaagccgg aggaggccat cggcaagagg     2400

atcaagaggt tcttcaacct gaagtacggc tcctccgtgc cgaagttcgt gtccgacgac     2460

aggggcaggg tgaccttcgc caagaagatc gactccaccc agaccaggct gatcaaccag     2520

ttcgtgtacg cccactcctc ctgcatcgtg acctgcgagc tgcacaacga gatggtgaac     2580

aagatcaagc agctggccgt ggagaagccg aactgccagg agttcgacgt gacctgcgac     2640

ccggacggca ggtacaacaa cttcgccctg ccggaggtgc acgactcctc caaggacgtg     2700

ggcgccaagg ccctgaccac caaggacgtg gacttcaaga ccatcctgaa ggaccacacc     2760

gcctccaggg ccgacccgaa gaagaagagg aaggtgtga                            2799


<210>  99
<211>  3927
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 78ʾںϵ׵ı

<400>  99
atgggcaaga acgagaacaa gtaccagctg tccaagaccc tgaggttcgg cctgaccctg       60

aaggagaaga tctccaacaa cgagaagacc ccgtaccagt cccactccca gttcagggac      120

ctgatcatcc tgtccgagaa caggatcagg gagggcatct ccaccccgca gaacagggac      180

ctgccgtcct tcatccacag gatccagaac tgcaccgact tcatcaacga cttcatccac      240

gactggtgga tgatcctgat gcacaccggc cagatcgagc tggacaagga ctactacaag      300

tccctgacca agaaggtggg cttcgtgggc ttctggtaca aggagaacaa gaagaagggc      360

ggcaagacca agcagccgca ggccaggaac atcccgatgg gcgagctgag gcacctgtgc      420

ccgcagaaca ccaaggagtg cgccacctac atcaccgact actggaagga cctgctgatc      480

accgccacca acaagctgta cgagtcctcc gagcagcaga agaagttcat caaggccatg      540

gagcagaaca ggaccgacaa caagccgaac gagatcgacc tgaagaagtc cttcctgtcc      600

ctggtgtccg tgaccatgga gctgctgaac ccgatcctga acggccagat cctgttcaac      660

aagatggaca ggctggacat gtccaagaag tccgacaacg acttcatcga cttcgtgaac      720

gaccacgaga ccgtgaggga gctgaacaac gacatcgagg agatcatcgc cgacttcaag      780

gagaacggca acaacgtgaa ctactgcaag gccaccctga acccggacac cgccctgaag      840

cagcacaaca acaacatccc gaacgacatc gccaccgacc tggaggagct gatgatggac      900

tccatcgtgg gcaactacga cgacgtgaac tccttcatgg acaactacgt gtccaacctg      960

tccgccaagg acaagatcaa gaagatcaag gactccaaca tctccctgat ctacagggcc     1020

atcctgttca agtacaagat gatcccggcc aacgtgagga gggacatcgc ccagggcatg     1080

gccaagaagc tgaacaagga cgaggagaac atctactcct tcctgtgcga gttcggcacc     1140

ctgaggaccc cgcagaagga ctacgccgac ctgaaggaca aggactcctt caacctggac     1200

aactacccgc tgaaggtggc cttcgacttc gcctgggagg gcctggccaa ggcctggtac     1260

cacgaccagt ccgacttccc gatcgacccg tgcagggact tcctgcagga gaacttcgac     1320

gtgaacctgg aggaggacca ggaggacgag tacttcctgc tgtacgccga cctgatcgag     1380

ctgaacgccc tgctgtccac cctggacaag ggcaacccgg ccgacccgga ctccatcaag     1440

aacgaggccc tggagatggt ggagtacatc aactggaact ccctggacaa gaagaacggc     1500

aactactaca agaagatcat caagaacagg ctgaagtcct ccaagggcaa cgagacctac     1560

gagaggatca agaaggagat ctccatgtcc aggggcaggc tgaagaacaa gatcgagaag     1620

tacgacgacc tgacctccca gtacaagagg atcgccatgg acctgggcaa gaagttcgcc     1680

tccctgaggg acaagatcat cgccgccaac gaggacaaca aggtgaccca ctacgccatg     1740

atcctggagg actccaactg cgacaagtac ctgctgctgc agaaggtgtc caacaacatc     1800

taccactgca tgtcctacga ctcctccgac ccgaaggcct actacgtgga ctccatcacc     1860

tcctccgcca tcgccaagat gatcaggaag gagaccaacc cgtccaagat cagggagtac     1920

gccgagctgg aggagaagga gagggagagg aggaacgtgg acgactggtg caggttcatc     1980

tccaagaagg agtacgacag gaggtaccag ctgaacatca acaacggcct gtccttcgag     2040

gccctgaaga aggagatcga ctccaagtcc tacatcctgg tgaagaagaa catctccgtg     2100

gactccatca gggagctggt ggagaacgag ggctgcctgc tgttcccgat cgtgaacaag     2160

gacctgacca aggagaggaa gaccaccgag gacaaccagt tcaccaagga ctggaacatg     2220

atcttctccg gctccgagac caactggagg ctgaccccgg agttcagggt gacctacagg     2280

aacccggtgc cgggctaccc gaacgacaag ttcggctcca agaggtactc caggttccag     2340

atgaacgccc acttcgtgtg cgacttcatc ccgtcctcca actcctacac ctccaacagg     2400

gagcagatcg ccatcttcaa ggacgagggc gagcagaaga agagggtgga ggagttcaac     2460

aggaccctgt ccaacatcaa ccagaagttc tacgtgatcg gcatcgacag gggccagaag     2520

gagctggcca ccctgtgcgt ggtggaccag gacaagaaga tccacggcga cttcaagatc     2580

tacaccagga agttcaactc cgagaggaag cagtgggagc actactccct ggagggcgag     2640

aagggcacca ggaacatcct ggacctgtcc aacctgaggg tggagaccac catcatcatc     2700

gacggcaagc cggagaggag gcaggtgctg gtggacctgt ccgaggtgct ggtgaaggac     2760

aaggagggca actacaccaa gccgaacaag atgcagatca agatgcagca gatggcctac     2820

gtgaggaagc tgcagttcca gatgcaggcc aacccgaccg aggtgctgga gtggtacgag     2880

cagaacccga ccgaggagct gatcatcaag aacctggtgg acaaggagaa cggcgagaag     2940

ggcctgatct ccttctacgg caccgccctg gtggagctgg accagaccct gccggtgtcc     3000

aagatcaagg agatgctgga ggagttcaag atcctgaagc agagggagtc caagaaggag     3060

aacgtgcaga aggagctgaa caacctgacc cagctggagg ccgtggactc cctgaaggcc     3120

ggcatcgtgg ccaacatggt gggcgtgatc tcctacatcc tgaagaccct ggactacaac     3180

gcctacatct ccctggagga cctgtccacc gtgcagtcct ccaccgagtt cgcctccggc     3240

atctccggcg ccatcaccaa gatgtccagg gaggagggca ggaggatcga cgtggagaag     3300

tacgccggcc tgggcctgta caacttcttc gagatgcagc tgctgaggaa gctgcacagg     3360

atccagaccg acaacggcaa catcctgcac ctggtgccgg ccttcagggc ccagaagaac     3420

tacgaccaca tcatggtggg caaggagaag atcaagaacc agttcggcat cgtgttcttc     3480

gtggacgccg ccgccacctc catcaagtgc ccgaggtgcg gcgccgtgaa cgaggacaag     3540

ttcaacccgg acaagcagaa gtacccggac gccgagaagg gcccgaagct gaggaacagg     3600

aaggagcagt ccggcaagaa ggtgtgggtg accagggaca aggaggacga cgacaggatc     3660

aagtgctact gctgcggctt cgacaccaag gagaagaacg agggcaaccc gttcatgtac     3720

atcaagtccg gcgacgacaa cgccgcctac ctgatctccg acctgggcgt ggagtcctac     3780

aggaaggcct acgagctggc cgccaccgtg gtggaggaca ggaagaagac cctgaccaac     3840

aacctgaacc agtccaacta caagatcagg ttcctgtggc acaccatgta ctccagggcc     3900

gacccgaaga agaagaggaa ggtgtga                                         3927


<210>  100
<211>  3807
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 79ʾںϵ׵ı

<400>  100
atggacgccg acaagaccac caaggccatc aacgagtacc agacccagaa gaccatcagg       60

ttcggcctga ccgccaccaa ccagaacctg tactccgagg agatcatgaa gctgctgaac      120

atctccgagg agaggatcat caaggagaag gtgaaggtga acaacgacac cgacaagacc      180

aaccagctga ggggctgcct ggtgcagatc aagaagtacc tgaagacctg ggagaacatc      240

tacgcccaga tcgacttcct ggccatcacc aaggactact acaaggtgat ctccaagaag      300

gccaggttcg acttcgacaa gggcaacggc tccgagatca agctgtcctc cctgcagtcc      360

acccacaaca agaagaagag gtaccagtac atcatcgact tctggaagga gaacctgagg      420

aagaccgaga acctgtacag gaagtccgac gacctgctga agatcttcga ggaggccaag      480

aaccagaaca gggacgacaa gaagctgaac aaggtggagc tgaggaagac cttcctgaac      540

ctgttcaccc tggtgaacga gtccctgaag ccgctgatcg agggcaacct gttcatcgtg      600

aacgacgaca agatcgacga gaagaactcc aagcacaact acgtgttcta cttcatctcc      660

aagaccgagg agaggaggct gctgtacgac aacatctgca ccctgcagga ctacttcaag      720

aacaacggcg gctacgtgcc gttcggcagg gtgaccctga acaagtggac cgccctgcag      780

aagttcaaca acagggacat cgagatcaac aggatcatca aggagctgaa gatcaacaac      840

atctccaccc agaagaccga ctacaagtac aacgacttca ccgagaactt caaggagaag      900

aaggacgaga acggcaaggt ggtgaagaac tccgccggca acatcatctg ggacctgaag      960

gccaacgcca agtccgtgat cgagatctgc cagttcttca agtacaagaa ggtgccgatc     1020

aacgccaggc tgaacctggc caagaggctg atcaaggaca acaagctgaa gaaggagcag     1080

gagaacacct tcctgtccga gttcggcgtg ctgaagaccc cggccttcga ctacgccagg     1140

gacaaggaga acttcaacct gaccaactac ccgctgaagg tggccttcga ctacgcctgg     1200

gagaactgcg ccaaggacaa gtacgagaag atcccgttcc cgaaggagca gtgcgagagg     1260

tacctgcaga ccgccttcga gatcgacgcc accaaggacg agaacaagaa gctgatcgac     1320

acccacctga acaagtacgc cgacctgctg cagttcaaga tcctgctgga gaggttcaag     1380

gccgagttcc acaagaccaa cgaggagacc aacaagaaca acatccagaa gctgaggaac     1440

gtgttctccg gcctggacta ccacggcgac aacaggctga acaagaacca gatccagaag     1500

gccatcgagg cctggttcga caacaaggag cagaacatcg gcaagaagaa ggagaacgag     1560

aagctgctga ccgagaacga gaagaacaac ttctccctgt ccatgcagat catcggccag     1620

gagaggggcg gcctgaagaa cggcatcccg aagtacaagg agctgaccga gatgttcaag     1680

gtgtgcgcct ccaagttcgg caagcagttc gccgacctga gggactactt caacgaggcc     1740

tacgaggtgg acaagatcaa gtacagggcc tggatcatcg aggacgacaa gaagaacagg     1800

ttcgtgctgt tcgtgaacaa ggagaaggcc ttcgacctga cctccgagga gggcgacctg     1860

tggttctacg aggtgaagtc cctgacctcc aagtccctgg tgaagttcat caagaacagg     1920

ggcgcctacc cggacttcca cgacgtgaag aactccttcc actactcctc catcaagaag     1980

gactggcaga actacaagaa cgacccggag ttcctggaca agctgaagga gtgcctgaag     2040

aactccaaga tcgccaagga ccagaagtgg gccaagttct gctgggactt caagcagtgc     2100

gacacctacg agaagctgga gaaggaggtg gacaggaagg gctacaagct ggagggctgc     2160

aagtccgagc cgaagaccat ctccctgacc cagctgaccg actgggtgga gaacaaggac     2220

tgcttcctgc tgccgatcgt gaaccaggac atcaacaagg gcgacaagag gaccaagaac     2280

cagaaccagt tcaccaagga ctggttcgac atcttcgaga acaagaagag gctgcacccg     2340

gagttcaaca tcttctacag gttcccgacc aaggactacc cgaacaccaa gttcaagaac     2400

ggcaccgaga agaccaagag gtactccagg ttccagatgc tggcctactt cggctgcgag     2460

gtgatcccgt ccggcaacca cctgtccaag aaggagcaga tcgccatctt caacaacgac     2520

aagaagcaga aggaggaggt ggagaagtac aacaagtcca tctcctccga ctgcgactac     2580

gtgatcggca tcgacagggg catcaagcag ctggccaccc tgtgcgtgct ggacaagaac     2640

ggcgtgatcc agggcgactt ccagatcttc accaggacct tcaacaagca gaccaagcag     2700

tgggagcaca aggagctgga gcagaggaac atcctggacc tgtccaacct gagggtggag     2760

accaccatca ccggcaagaa ggtgctggtg gacctgtcca agatcaagga cgacgagggc     2820

aactacacca acctgaagca gaccatcaag ctgaagcagc tggcctacat cagggagctg     2880

cagtacgcca tgcagaccag gccggacgac ctgctggact tcgtgaagtc catcaactcc     2940

gccaacgaca tcaccgccga gaacatcaag cacttcatct ccccgtacaa ggagggcaag     3000

aactacgacg acctgccgaa ggtggagatg ttcaacctgc tgaaggagtg gggcaacgcc     3060

gacgagaacg gcaagaggaa gatcgccgag ctggacccgg ccgacaacct gaagtccggc     3120

atcgtggcca acatggtggg cgtggtggcc ttcctgtgcg agaactacaa ctacaaggtg     3180

aggatcgccc tggaggacct gaccagggcc tacggcatcc agaaggacgc cctgaacggc     3240

accgccatct accagaacga cgaggacttc aaggagcagg agaacaggag gctggccggc     3300

gtgggcacca tgcagttctt cgaggtgcag ctgctgagga agctgttcaa gatccaggtg     3360

gacaagaacc tgcacctgat cccggccttc aggtccgtgg acaactacga gaagatcgtg     3420

aggagggaca agcagaactc cggcgacgag ttcgtgaact acccgttcgg catcgtgtgc     3480

ttcgtggacc cgaagtacac ctcccagcag tgcccgtact gcaacaacac ccacaagcac     3540

aagaagaacg acaccgagac cggcaagaag gccttctaca ggaacaaggg cgagaacaag     3600

aactccctgc tgtgcgagaa gtgcggcgtg tccaccatcg agggcgagga gaccctgtcc     3660

tccaagaacg acaacaagaa gcagttcaac atccactaca tcaccgacgg cgaccagaac     3720

ggcgcctacc acatcgccaa caaggtggtg atcaacttcc agaaggactc ctccagggcc     3780

gacccgaaga agaagaggaa ggtgtga                                         3807


<210>  101
<211>  3069
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 80ʾںϵ׵ı

<400>  101
atggactacc agcagtacga gttcaccagg accatcaggt tcaacctgtc cggcgacgac       60

aagagggccc tgatgctgga cctgctggac gacacccagg agggcatgct ggccgccttc      120

caggagacct acaagaacct gctgttcgcc ttccaggagg ccatcctgag ggccgacggc      180

tccggcaacc tgagggtggg caggctggag atcaagaagt cctggctgag gcagtacgcc      240

agggagtact tctacgccct gtccgaggac gagaggaggt gcaagaacaa gttccaggcc      300

aagctgttcg acagggtgct gtccgactgg ctggagagga acaacgagct gctgcagagg      360

ctgaacaaca tcctgtccct gccgcaggag tccaagaccg gcgcctccga cctgtccctg      420

ctggtgaggc agctgaaggg cgccgagtac ttctacttca tcagggactt cacccagtcc      480

ggcatcatca acgacaagga ctccgacgag cacatcaaga acctggccgg catcgtggag      540

aagttcgaga ccctgctgga caaggtgctg ttcctgaccg ccccgaactc ctcccagggc      600

gtggagacca ccagggcctc cttcaactac tacaccgtga acaagatctc caagaacttc      660

gacgagaaca tcaagaaggc caacggcagg ctgtgctcct cctaccagaa ctccatgaac      720

gaggagctgc tgaggaaggt gggcttcctg aagtacctga aggacgagta cagggccgag      780

ctgcagaacg tgtccctgaa ggacctgtac gaggccctga agaagttcaa gtcccagcag      840

aagaccgcct tcatccaggc cgtgcagaag aacaagtccg agaaggagct gatgagggag      900

ttcccgctgt tcaacggcaa gcagccggac accctgcaga agttcatcct ggagaccgac      960

aagatcaaga ggggcgccta cttccagaag tggggcttcg acaactacat ctccttctgc     1020

aacaagatct tcaagccggt ggccatggag accggcacca ggaaggccaa gatcagggcc     1080

ctggagcagg agaagatcga ggccaggctg ctgcagtact gggcccacat cctggtgaag     1140

gacggcaagt acttcctgct gctgatcccg aaggagaaga tgggcgaggc caaggtgttc     1200

ttcgccaggc tgtccgacca ggagggcggc gagtacaccc tgtacgcctt caactccctg     1260

accctgaggg ccctgaagaa gctgatcagg aggaacctgg gcaaggagca ggtgaggctg     1320

tccgccggcg acgccgacgc catcgccctg tgccaggagg tgctgagggg caggtaccac     1380

cagctgaagg acctggacct gtccggcttc gagaaggaga tcgccgagat cgccaacacc     1440

cagtacgaga acgaggagga gttcaggatc gccctggagc aggtggccta ctacctgtcc     1500

gagaggaaga tgaacgagga gtccatcgag tacctgaaga agaacctggg cgccatcctg     1560

ctggagatct cctcctacga cctggagagg aacatcaccg gcgagtccaa ggagcacacc     1620

aggctgtggt ccgacttctg gaacccgaac aacaagaagg agtgcttctc caccaggctg     1680

aacccggagc tgaggatctt ctacaggccg ccgagggagc agaaggaccc gaagaagcag     1740

aagaacaggt tctccaagga ccacctggcc gtggccttca ccatcgccca gaacgccgcc     1800

aggaagagga tggagacctc cttcgccgag gagaaggacc tggtggagca ggtgaagaag     1860

ttcaacgagg aggtggtggg caagttcatc gacgagaagt ccgacaacct gtactactac     1920

ggcatcgaca ggggccagca ggagctggcc accctgtgcg tggtgaggtt ctccaaggag     1980

cactacgagg ccatgctgga ggacaacttc atcaagaagt tctccaagcc gatcccggcc     2040

cagatcaccg cctacaggat caaggacgag cacatgtcct acaggaagaa catcaccagg     2100

gacctgaagg gcaacgagac cgaggagatc ctgttcaaga acccgtccca cttcatcgac     2160

gaggtggaga acttcgagga ggtgtccacc ccgtgcatcg acctgaccac cgccaagctg     2220

atcaagggca agatcatcct gaacggcgac atccagacct acctggccct gaagaaggcc     2280

aacggcaaga ggcagctgtt cgagaagttc gccaagatcg acgactccgc caagatcgag     2340

ttcgacgact ccgagggcag gttccaggtg aagtccaagg ccaccgagag ggaggagtac     2400

cagttcctgc cgtactacgg cccggagcag gagaacatct ccccgaggga ggacatgagg     2460

agggagctgc aggcctacct ggacaagctg aggtcctccg agtccttcga ggaggacatc     2520

tccatcgaga agatcaacca cctgagggac gccatcacct ccaacatggt gggcatcatc     2580

gccttcctgt tcaccgagta cccgggcatc atcaacctgg agaacctgca ctccagggag     2640

aacatcgaga agaactggag gaagaacaac gaggacatct ccaggaggct ggagtggggc     2700

ctgtacaaga agttccagaa gatcggcctg gtgccgccga ggctgaggca gaccgtgctg     2760

ctgagggaga acgagaccga gaggcaggag aagctgaacc agttcggcat catccacttc     2820

atcccgaccg agaagacctc cgccaggtgc ccgtactgcg gcgagaacac cccgatgaag     2880

cagaggaacg aggacaagtt caagctgcac gcctacatct gcaggtccaa cgaggagaac     2940

tgcggcttcg acaccaggga gccgaagtcc ccgctggagt tcatcaagaa ctccgacgac     3000

gtggccgcct acaacatcgc caagaagagg ctgtccaggg ccgacccgaa gaagaagagg     3060

aaggtgtga                                                             3069


<210>  102
<211>  3237
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 81ʾںϵ׵ı

<400>  102
atgaagaacg gcatcaacct gttcaagacc aagaccacca agaccaaggg cgtggacatg       60

gagaagtacc agatcaccaa gaccatcagg ttcaagctgc tgccggacaa cgcccacgag      120

atcgtggaga aggtgaagtc cctgaagacc tccaacgtgg acgagctgat ggacgaggtg      180

aagaacgtgc acctgaaggg cctggagctg ctgttcgccc tgaagaagta cttctacttc      240

gacggcaacc agtgcaagtc cttcaagtcc accctggaga tcaaggccag gtggctgagg      300

ctgtacaccc cggaccagta ctacctgaag aagtcctcca agaactccta ccagctgaag      360

tccctgtcct acttcaagga cgtgttcaac gactggctgt tcaactggga ggagtccgtg      420

tccgagctgg ccatcatcta cgagaagtac aagatctgcc agcaccagag ggactccagg      480

gccgacatcg ccctgctgat caagaagctg tccatgaagg agtacttccc gttcatctcc      540

gacctgatcg actgcgtgaa cgacaagaac tccaacaaga ccttcctgat gaagctgtcc      600

gaggagctgt ccgtgctgct ggagaagtgc aactccaggg ccctgccgta ccagtccaac      660

ggcatcgtgg tgggcaaggc ctccctgaac tactacaccg tgtccaagtc cgagaagatg      720

ctgcagaacg agtacgagga cgtgtgccag tccctggaca agaactacga catcaccgag      780

atgaaggtga tcctgtacaa ggagaagctg gacaacctga acttcaagga cgtgaccatc      840

gccaacgcct acaacctgct gaaggagaac aaggccctgc agaagaggct gttctccgag      900

tacgtgtccc agggcaaggt gctgtccctg atcaagaccg agctgccgct gttctccaac      960

atcaacgaca acgacttcga gaagtacaag gagtggtcca acgagatcaa gaagctggcc     1020

gacaagaaga acaccttctg caagaagacc cagcaggaca agatcaagga catccagaac     1080

aagatctccg agctgaagaa gaagaggggc gccctgttcc agtacaagtt cacctccttc     1140

cagaagcact gcgacaacta caagaaggtg gccgtgcagt acggcaagct gaaggccagg     1200

aagaaggcca tcgagaagga cgagatcgag gccaacctgc tgaggtactg gtccgtgatc     1260

ctggagcagg aggacaagca ctccctggtg ctgatcccga agaacaacgc caaggacgcc     1320

aagcagtaca tcgagaccat caacaccaag ggcggcaagt acatcatcca ccacctggac     1380

tccctgaccc tgagggccct gaacaagctg tgcttcaacg ccgtggacat cgagaagggc     1440

cagatggtga gggagaacac cttctaccag ggcatcaagg aggagttcga gaggaacaag     1500

atcaactgcg acaaccaggg cgtgctgaag atccagggcc tgtactcctt caagaccgag     1560

ggcggccaga tcaacgagaa ggaggccgtg gagttcttca aggaggtgct gaagtccaac     1620

tacgccaggg aggtgctgaa cctgccgtac gacctggagt ccaacatctt ccagaaggag     1680

tacaccaacc tggaccagtt caggcaggac ctggagaagt gctgctacgc cctgcactcc     1740

aagatcggca aggacgacct ggacgagttc accaggaggt tcgaggccca ggtgttcgac     1800

atcacctcca tcgacctgaa gtccaagaag gagaagacca agaccaccgg cgagatgaag     1860

aagcacaccc agctgtggct ggagttctgg aagggcgcca tcgagcagaa cttcgccacc     1920

agggtgaacc cggagctgtc catcttctgg agggccccga agtcctccag ggagaagaag     1980

tacggcaagg gctccgacct gtacgacccg aacaagaaca acaggtacct gtacgagcag     2040

tacaccctgg ccctgaccat caccgagaac gccggctccc acttcaagga catcgccttc     2100

aaggacacct ccaagatcaa ggaggccatc aaggagttca acatgtccct gtcccagtcc     2160

aagtactgct tcggcatcga caggggcaac gccgagctgg tgtccctgtg cctgatcaag     2220

aacgagaagg acttcccgtt cgagaagttc ccggtgtaca ggctgaggga cctgacctac     2280

cagggcgact tcaaggacaa gcacgaccag atgaggtacg gcgtggccat caagaacatc     2340

tcctacttca tcgaccagga ggacctgttc gagaagaaca acctgtccgc catcgacatg     2400

accaccgcca agctgatcaa gaacaagatc gtgctgaacg gcgacgtgct gacctacctg     2460

aagctgaagg aggagaccgc caagcacaag ctgacccagt tcttccaggg ctcctccatc     2520

aacaagaact ccagggtgta cttcgacgag gacgagaacg tgttcaagat caccaccaac     2580

aggaaccaca acccggagga gatcatctac ttctacaggg gcgagtacgg cgccatcaag     2640

aacaagaacg acctggagga catcctgaac gagtacctgt gcaagatgga gaccggcgag     2700

tccgagatcg tgctgctgaa cagggtgaac cacctgaggg acgccatctc cgccaacatc     2760

gtgggcatcc tgtcctacct gatcgacctg ttcccggaga ccatcgtggc cctggagaac     2820

ctggccaagg gcaccatcga caggcacgtg tcccagtcct acgagaacat caccaggagg     2880

ttcgagtggg ccctgtacag gaagctgctg aacaagcagc tggccccgcc ggagctgaag     2940

gagaacatcc tgctgaggga gggcgacgac aagatcgacc agttcggcat catccacttc     3000

gtggaggaga agaacacctc caaggactgc ccgaactgca ggaagaccac ccagcagacc     3060

aacgacaaca agttcaagga gaagaagttc gtgtgcaagt cctgcggctt cgacacctcc     3120

aaggacagga agggcatgga ctccctgaac tccccggaca ccgtggccgc ctacaacgtg     3180

gccaggaaga agttcgagtc ctccagggcc gacccgaaga agaagaggaa ggtgtga        3237


<210>  103
<211>  3309
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 82ʾںϵ׵ı

<400>  103
atggccggca ccccgtacac cggccacgtg gcctgcaagt actgcaagat cacctcctgg       60

gccacctacg acaggatcaa gatcaacaag atcaacatga accagtcctt catcaacggc      120

cagaacttct acgagctgag gaagaccatc aggttcgtgc tggacccgaa gaccctgaag      180

aggccgtaca ccccgtcctc cgacgaggtg aacctggagg agcagctgaa caacttcatc      240

gagaagtacc agcagggcat caacgacttc aagtacatcg tgtacttcgg cccgaagacc      300

gccgagacca aggagctgaa caagaagatc tccatcaagc actcctggct gaggaactac      360

accaagtccg agttctactc catcaaggac aagctgatcc agctggacta caacggcaac      420

aaggcctcca tcggcaactc caacctgaag ttcctgaacg agtacttcga gaactggatc      480

tccgagaacc aggagtgcgc cgacgccctg aagaactgca tcaacgcccc ggccgagaag      540

cagaagagga agtccgaggc cgcccactgg gtgaggaagc tgaccaagag gtccaacttc      600

gagtgcatct tcgagctgtt caacggcaac atcgaccaca agaactccaa cgacgacatc      660

gagaagatca agcactgcct gaacgagtgc aagaccctgc tgacctccct ggagaagatg      720

ctgctgccgt cccagtccct gggcatggag atcgagaggg cctccctgaa ctactacacc      780

atcaacaaga agccgaagaa ctacgacgag gacatcgccc agaaggcctc cgccctgaac      840

gaggcctacc agttcaaggc cgacgacaag gccttcctga acagggtggg cttctccgac      900

gacggcgtgc cgatcaacga gctgaaggag gccatgaaga agttcaaggc cgaccagaag      960

tccaagttct acgagttcgt gaaccagaag aagtcctact ccgacctgaa gaagaacgac     1020

gacctgaagc tgctgaacga catctccgag gaggacttca acaagttcaa ggagacccag     1080

gacaagatga ccaggggcaa gcacttccag ttctccttcc cgaactacaa gaagtccgag     1140

aagaacttct gcgacctgta caagaacgtg gccgtggcct tcggcaagat cagggccgac     1200

atcaaggccc tggagaagga gaggatggac gccgagaagc tgcagtgctg ggccgtgatc     1260

ctggagaagg acaaccagag gtacgtggtg accatcccga gggacgccaa caacaacctg     1320

accaacacca agcagtacat cgacaacctg cagaacgagg agaacgacca gtggatcctg     1380

tacgccttcg agtccctgac cctgaggtcc ctggacaagc tgtgcttcgg cctggacaag     1440

aacaccttca tcccggccat caccggcgag ctgtaccaga agaacaactc cttcttcgag     1500

aagggcctgc tgaagaggaa ggaccagttc tcccagaacg gcaccgacct ggccgccttc     1560

tacaagaccg tgctggagct ggactccacc aagaagatgc tgggcatcaa caagtacgcc     1620

gacttcaagg ccttcatctc caaggagtac accgccctgg aggacttcga gaagaccctg     1680

aaggagacct gctacttcaa gaagagggtg ttcatctccg aggacaccaa gaacaagctg     1740

atcaacgact accagggcaa cctgtacaag atcacctcct acgacctgga gaaggacgac     1800

tccgaggccc tgggcaccct gatcaacaag aagcagttca acagggcctc cccggagatc     1860

cacaccaaga cctggctgga cttctggacc gccgacaacg agaccgacaa gtacccgatc     1920

aggctgaacc cggagttcaa gatctccttc gtggagaagc aggacaagga cctgaacatg     1980

aggaacctgg gcctgctgaa caagaacagg aggctgaagt cccagttcct gctgtccacc     2040

accatcaccc tgctggccca cgagaagaac gccgacctgc acttcaagaa gaccgacgag     2100

atccagacct tcatcaactc ctacaaccag gagttcaaca agaagatcaa gccgttcgac     2160

atctactact acggcctgga caggggccag aaggagctgc tgaccctggg cctgttcaag     2220

ttctccgaga acgagaaggt gtccttcacc aagcaggacg gcaccgtggg cgagtactcc     2280

aagccgaagt tcatcccgct ggacgtgtac cagatcaggg agggccagta cctgaccaag     2340

aacaagaagg gcaggctggc ctacaagtcc atcgaccagt tcatcgacga cgagaaggtg     2400

atcgagaagc tgccggtgaa ctcctgcctg gacctgtcct gcgccaagct ggtgaagggc     2460

aagatcatcc agaacggcga cgtggccacc tacctggagc tgaagagggt gtccgccctg     2520

aggaagatct acgagaacac caccaggggc cagttcaaga ccgacaggat cggcttcaac     2580

aaggacaagg gctgcctgtt cctggacatc gagaacaggg gcaagctgga gaacaacaac     2640

ctgtacttct acgacaacag gttcgccgag atcctgtccc tggactccat catcaaggag     2700

ctgcaggact actacaacga ggtgaagaac aagcagaaca tcgagttcat ctccatcgac     2760

aagatcaacc acctgaggga cgccctgtgc gccaacgccg tgggcatcct ggcccacctg     2820

cagaagaccc acttcggcgt gatcgtgttc gagggcctgg acgccaggca caagaacaag     2880

gagaccaccg agttcgccgg caacctggcc tccaggatcg agaggaagat cctgcagaag     2940

ctggagaccc tgtccctgat cccgccgcag cacaggcaga tcatcgacct gcagaactcc     3000

aagcagatca agcagaccgg cgccgtgctg tacatcgagg agaagggcac ctccgccaac     3060

tgcccgcact gcgagaccgc caacccggac aagtccgaga agtggctggc ccacaactac     3120

aagtgcaaga actccaactg caacttcgac gcctccgaga tctccaagag gaaggacctg     3180

atcggcctgg acaactccga ctccgtggcc acctacaaca tcgccaagag gggcctgctg     3240

gagatgaacc agaagatcga gcagtccaag gtgtccaggg ccgacccgaa gaagaagagg     3300

aaggtgtga                                                             3309


<210>  104
<211>  3207
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 83ʾںϵ׵ı

<400>  104
atggagatcc aggagctgaa gaacctgtac gaggtgaaga agaccgtgag gttcgagctg       60

aagccgtcca agaagaagat cttcgagggc ggcgacgtga tcaagctgca gaaggacttc      120

gagaaggtgc agaagttctt cctggacatc ttcgtgtaca agaacgagca caccaagctg      180

gagttcaaga agaagaggga gatcaagtac acctggctga ggaccaacac caagaacgag      240

ttctacaact ggaggggcaa gtccgacacc ggcaagaact acgccctgaa caagatcggc      300

ttcctggccg aggagatcct gaggtggctg aacgagtggc aggagctgac caagtccctg      360

aaggacctga cccagaggga ggagcacaag caggagagga agtccgacat cgccttcgtg      420

ctgaggaact tcctgaagag gcagaacctg ccgttcatca aggacttctt caacgccgtg      480

atcgacatcc agggcaagca gggcaaggag tccgacgaca agatcaggaa gttcagggag      540

gagatcaagg agatcgagaa gaacctgaac gcctgctcca gggagtacct gccgacccag      600

tccaacggcg tgctgctgta caaggcctcc ttctcctact acaccctgaa caagaccccg      660

aaggagtacg aggacctgaa gaaggagaag gagtccgagc tgtcctccgt gctgctgaag      720

gagatctaca ggaggaagag gttcaacagg accaccaacc agaaggacac cctgttcgag      780

tgcacctccg actggctggt gaagatcaag ctgggcaagg acatctacga gtggaccctg      840

gacgaggcct accagaagat gaagatctgg aaggccaacc agaagtccaa cttcatcgag      900

gccgtggccg gcgacaagct gacccaccag aacttcagga agcagttccc gctgttcgac      960

gcctccgacg aggacttcga gaccttctac aggctgacca aggccctgga caagaacccg     1020

gagaacgcca agaagatcgc ccagaagagg ggcaagttct tcaacgcccc gaacgagacc     1080

gtgcagacca agaactacca cgagctgtgc gagctgtaca agaggatcgc cgtgaagagg     1140

ggcaagatca tcgccgagat caagggcatc gagaacgagg aggtgcagtc ccagctgctg     1200

acccactggg ccgtgatcgc cgaggagagg gacaagaagt tcatcgtgct gatcccgagg     1260

aagaacggcg gcaagctgga gaaccacaag aacgcccacg ccttcctgca ggagaaggac     1320

aggaaggagc cgaacgacat caaggtgtac cacttcaagt ccctgaccct gaggtccctg     1380

gagaagctgt gcttcaagga ggccaagaac accttcgccc cggagatcaa gaaggagacc     1440

aacccgaaga tctggttccc gacctacaag caggagtgga actccacccc ggagaggctg     1500

atcaagttct acaagcaggt gctgcagtcc aactacgccc agacctacct ggacctggtg     1560

gacttcggca acctgaacac cttcctggag acccacttca ccaccctgga ggagttcgag     1620

tccgacctgg agaagacctg ctacaccaag gtgccggtgt acttcgccaa gaaggagctg     1680

gagaccttcg ccgacgagtt cgaggccgag gtgttcgaga tcaccaccag gtccatctcc     1740

accgagtcca agaggaagga gaacgcccac gccgagatct ggagggactt ctggtccagg     1800

gagaacgagg aggagaacca catcaccagg ctgaacccgg aggtgtccgt gctgtacagg     1860

gacgagatca aggagaagtc caacacctcc aggaagaaca ggaagtccaa cgccaacaac     1920

aggttctccg acccgaggtt caccctggcc accaccatca ccctgaacgc cgacaagaag     1980

aagtccaacc tggccttcaa gaccgtggag gacatcaaca tccacatcga caacttcaac     2040

aagaagttct ccaagaactt ctccggcgag tgggtgtacg gcatcgacag gggcctgaag     2100

gagctggcca ccctgaacgt ggtgaagttc tccgacgtga agaacgtgtt cggcgtgtcc     2160

cagccgaagg agttcgccaa gatcccgatc tacaagctga gggacgagaa ggccatcctg     2220

aaggacgaga acggcctgtc cctgaagaac gccaagggcg aggccaggaa ggtgatcgac     2280

aacatctccg acgtgctgga ggagggcaag gagccggact ccaccctgtt cgagaagagg     2340

gaggtgtcct ccatcgacct gaccagggcc aagctgatca agggccacat catctccaac     2400

ggcgaccaga agacctacct gaagctgaag gagacctccg ccaagaggag gatcttcgag     2460

ctgttctcca ccgccaagat cgacaagtcc tcccagttcc acgtgaggaa gaccatcgag     2520

ctgtccggca ccaagatcta ctggctgtgc gagtggcaga ggcaggactc ctggaggacc     2580

gagaaggtgt ccctgaggaa caccctgaag ggctacctgc agaacctgga cctgaagaac     2640

aggttcgaga acatcgagac catcgagaag atcaaccacc tgagggacgc catcaccgcc     2700

aacatggtgg gcatcctgtc ccacctgcag aacaagctgg agatgcaggg cgtgatcgcc     2760

ctggagaacc tggacaccgt gagggagcag tccaacaaga agatgatcga cgagcacttc     2820

gagcagtcca acgagcacgt gtccaggagg ctggagtggg ccctgtactg caagttcgcc     2880

aacaccggcg aggtgccgcc gcagatcaag gagtccatct tcctgaggga cgagttcaag     2940

gtgtgccaga tcggcatcct gaacttcatc gacgtgaagg gcacctcctc caactgcccg     3000

aactgcgacc aggagtccag gaagaccggc tcccacttca tctgcaactt ccagaacaac     3060

tgcatcttct cctccaagga gaacaggaac ctgctggagc agaacctgca caactccgac     3120

gacgtggccg ccttcaacat cgccaagagg ggcctggaga tcgtgaaggt gtccagggcc     3180

gacccgaaga agaagaggaa ggtgtga                                         3207


<210>  105
<211>  3510
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 84ʾںϵ׵ı

<400>  105
atggagaact tcaagaacct gtacgaggtg aggaagaccg tgaggttcga gctgaagccg       60

tccaggaaga agaccttcgc cggcggcgac atcttcgagc tgcagaagga cttcgaggag      120

gtgcagaagt tcttcctgga catcttcgtg ttcgccatcg agcaggagaa gctgtaccag      180

gaggaggagg aggagggcaa gctgtccagg tacaccaaga tcgagttcaa gaagaagagg      240

gagatcaagt acacctggct gaggatctac accaagaacg agttctacga ctggaacggc      300

aagaacgaca aggagaagaa ctacgccctg tccaagatcg acttcctgga gaaggagatc      360

ctgaggtggt tcaacgagtg gcaggagctg accgtgaacc tgaagaacct gacccagacc      420

aaggagcacg agaaggagag gaagtccgac atcgccttcg tgctgaggaa cttcctgaag      480

aggcagaact tcccgttcat caaggacttc ttcaacgccg tgatcgacat ccaggagaag      540

cagggcaacg agtccgacga gaagatcagg aagttcaggg aggagctgag ggagatgaag      600

aagaacctga acacctgcgc caaggagtac ctgtcctccc agtccaaggg cgtgctgctg      660

cacaaggcct ccttcaacta ctacaccctg aacaagaccc cgaaggagta cgagaacctg      720

aagctgcaga aggagctgga gatcgacaac atcctgccga agaagatctg caagagggtg      780

aggtggaaca aggagaagaa gcaggaggac atcctgttcg agtgcaactc cgactggctg      840

gtggagatca agctgggcta cgacatccag aagtggaccc tggacgaggc ctaccagaag      900

atgaagacct ggaaggccga ccagaagtcc gacttcaacg agaagatcgg caacttcatc      960

gaccagtacc tgaagaaggg cttcatcgag gacctgatga acgagaacga gaagaagaac     1020

gccgaggcca tcctgaggga gttctccgtg ttcaagccga tcgagaactt ctacttctac     1080

gacttcctgg agaggaccaa ggagatcaag atcctgtcca accagaagaa caacatcctg     1140

cagaagtaca acaagaacgc caagtacttc gagaagatca tcacctacaa gatcaaggac     1200

aaggaggacc tgaccgagga cgagaaggag taccaggagc tggagaagtc catcgagaag     1260

aaggccaagg agaggggcaa gttcttcaac gccccgaagg agaaggtgca gacccagcac     1320

tacttcgagc tgtgcgagct gtacaagagg atcgccatga agaggggcaa gatcatcgcc     1380

gagatcaagg gcatcgagaa cgaggaggtg cagtcccagc tgctgaccca ctgggccctg     1440

atcgccgagg agggcgagaa gaagtccgtg gtgttcatcc cgaggaagaa cggcgaggag     1500

ctggagaacc acaagaaggc ccacgagttc ctgcagaagc aggagaagaa ggagttcggc     1560

gacatcaagt cctaccactt caagtccctg accctgaggg ccctggagaa gctgtgcttc     1620

aaggagaccg agaacacctt caccccggag atcaagaagg agaccaaccc gaaggtgtgg     1680

ttcccgaagt acaagcagga gtggaacgac gagccgcaga agctgatcaa cttctacaag     1740

caggtgctgc agtccaagta ctcccagaag tacctggacc tggtggcctt cggcgacctg     1800

aagtccttcc tggagacctc cttcgacgac ctgcagatct tcgagtccgg cctggagaag     1860

acctgctaca tcaaggtgcc gatctacttc tccaaggagg gcttcgagac cttcaccaac     1920

aggttcgacg ccgaggtgtt cgagatcacc accaggtcca tctcctccga gtccaagagg     1980

aaggagaacg cccacgccga gatctggaag gacttctggt ccaaggagaa cgaggagaag     2040

aaccacatca ccaggctgaa cccggaggtg tccgtgttct acagggacga gatcgagaag     2100

aagtccaacg ccctgagggg caacaacaag tccaacatca acaacaggtt ctccgcctcc     2160

aggttcaccc tggtgaccac catcaccatc agggccaccc acaagaagtc caacctggcc     2220

ttcaagaccg aggaggacat caagtcccac atcgacaagt tcaacgaggc cttccagaac     2280

ttctccggcg agtgggtgta cggcatcgac aggggcctga aggagctggc caccctgaac     2340

gtggtgaagt tctccgacga gaagaacgag ttcggcgtga tcaagccgaa ggagttcgcc     2400

aagatcccgg tgtacaagct gaaggacgag aaggccatcc tgaaggacga gaacggcaag     2460

gacctgaaga acgccaaggg cgaggccagg aaggtgatcg acaacatctc cgaggtgctg     2520

gaggagaaga aggagccgga ctccaacctg ttcgagaagc agggcgtgct gtcccagggc     2580

atctcctgca tcgacctgac ccaggccaag ctgatcaagg gccacatcat cctgaacggc     2640

gaccagaaga cctacctgaa gctgaaggag atctccgcca agaggaggat cttcgagctg     2700

ttctccacct ccaagatcga caagaactcc gagctgaggg tggagaagac caccatctcc     2760

atcaactccg aggacggcaa gagggacttc tactggctga ccaagaacca gatcgtgaac     2820

tccgagacca agaaggagat ccagaaggag cagcaggaga agctggacaa cctgaaggtg     2880

atcttcatcg actacctgga gggcctgtgc gtgaagaaca agttcgagga catcgagacc     2940

atcgagaaga tcaaccacct gagggacgcc atcaccgcca acatggtggg catcctgttc     3000

cacctgcaga aggagttcaa gggcatcatc gccctggaga acctggacac cgtgagggag     3060

cagtccaaca agaagatgat cgacgagcac ttcgagcagt ccaacgagga catctccagg     3120

aggctggagt gggccctgta caggaagttc gccaacatgg gcgaggtgcc gtcccagatc     3180

aaggagtcca tcttcctgag ggacgagttc aaggtgtacc agatgggcct gctgaagttc     3240

gtggaggtgt ccggcacctc ctccaactgc ccgaactgcg acaaggaggt gggcaagacc     3300

aactcccact tcgtgtgcaa gggcgagaac aactgcggct tctcctccaa ggagaacagg     3360

aacctgctgg agcagaacct gaacaactcc gacgaggtgg ccgcctacaa catcgccaag     3420

aggggcctga agctgatcaa ccagaagtgg aacaacacct ccaagtccca gaactccagg     3480

gccgacccga agaagaagag gaaggtgtga                                      3510


<210>  106
<211>  3228
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 85ʾںϵ׵ı

<400>  106
atggagaagt acaagatcac caagaccatc aggttcaagc tgctgccgga caagatccag       60

gacatctcca ggcaggtggc cgtgctgcag aactccacca acgccgagaa gaagaacaac      120

ctgctgaggc tggtgcagag gggccaggag ctgccgaagc tgctgaacga gtacatcagg      180

tactccgaca accacaagct gaagtccaac gtgaccgtgc acttcaggtg gctgaggctg      240

ttcaccaagg acctgttcta caactggaag aaggacaaca ccgagaagaa gatcaagatc      300

tccgacgtgg tgtacctgtc ccacgtgttc gaggccttcc tgaaggagtg ggagtccacc      360

atcgagaggg tgaacgccga ctgcaacaag ccggaggagt ccaagaccag ggacgccgag      420

atcgccctgt ccatcaggaa gctgggcatc aagcaccagc tgccgttcat caagggcttc      480

gtggacaact ccaacgacaa gaactccgag gacaccaagt ccaagctgac cgccctgctg      540

tccgagttcg aggccgtgct gaagatctgc gagcagaact acctgccgtc ccagtcctcc      600

ggcatcgcca tcgccaaggc ctccttcaac tactacacca tcaacaagaa gcagaaggac      660

ttcgaggccg agatcgtggc cctgaagaag cagctgcacg ccaggtacgg caacaagaag      720

tacgaccagc tgctgaggga gctgaacctg atcccgctga aggagctgcc gctgaaggag      780

ctgccgctga tcgagttcta ctccgagatc aagaagagga agtccaccaa gaagtccgag      840

ttcctggagg ccgtgtccaa cggcctggtg ttcgacgacc tgaagtccaa gttcccgctg      900

ttccagaccg agtccaacaa gtacgacgag tacctgaagc tgtccaacaa gatcacccag      960

aagtccaccg ccaagtccct gctgtccaag gactccccgg aggcccagaa gctgcagacc     1020

gagatcacca agctgaagaa gaacaggggc gagtacttca agaaggcctt cggcaagtac     1080

gtgcagctgt gcgagctgta caaggagatc gccggcaaga ggggcaagct gaagggccag     1140

atcaagggca tcgagaacga gaggatcgac tcccagaggc tgcagtactg ggccctggtg     1200

ctggaggaca acctgaagca ctccctgatc ctgatcccga aggagaagac caacgagctg     1260

tacaggaagg tgtggggcgc caaggacgac ggcgcctcct cctcctcctc ctccaccctg     1320

tactacttcg agtccatgac ctacagggcc ctgaggaagc tgtgcttcgg catcaacggc     1380

aacaccttcc tgccggagat ccagaaggag ctgccgcagt acaaccagaa ggagttcggc     1440

gagttctgct tccacaagtc caacgacgac aaggagatcg acgagccgaa gctgatctcc     1500

ttctaccagt ccgtgctgaa gaccgacttc gtgaagaaca ccctggccct gccgcagtcc     1560

gtgttcaacg aggtggccat ccagtccttc gagaccaggc aggacttcca gatcgccctg     1620

gagaagtgct gctacgccaa gaagcagatc atctccgagt ccctgaagaa ggagatcctg     1680

gagaactaca acacccagat cttcaagatc acctccctgg acctgcagag gtccgagcag     1740

aagaacctga agggccacac caggatctgg aacaggttct ggaccaagca gaacgaggag     1800

atcaactaca acctgaggct gaacccggag atcgccatcg tgtggaggaa ggccaagaag     1860

accaggatcg agaagtacgg cgagaggtcc gtgctgtacg agccggagaa gaggaacagg     1920

tacctgcacg agcagtacac cctgtgcacc accgtgaccg acaacgccct gaacaacgag     1980

atcaccttcg ccttcgagga caccaagaag aagggcaccg agatcgtgaa gtacaacgag     2040

aagatcaacc agaccctgaa gaaggagttc aacaagaacc agctgtggtt ctacggcatc     2100

gacgccggcg agatcgagct ggccaccctg gccctgatga acaaggacaa ggagccgcag     2160

ctgttcaccg tgtacgagct gaagaagctg gacttcttca agcacggcta catctacaac     2220

aaggagaggg agctggtgat cagggagaag ccgtacaagg ccatccagaa cctgtcctac     2280

ttcctgaacg aggagctgta cgagaagacc ttcagggacg gcaagttcaa cgagacctac     2340

aacgagctgt tcaaggagaa gcacgtgtcc gccatcgacc tgaccaccgc caaggtgatc     2400

aacggcaaga tcatcctgaa cggcgacatg atcaccttcc tgaacctgag gatcctgcac     2460

gcccagagga agatctacga ggagctgatc gagaacccgc acgccgagct gaaggagaag     2520

gactacaagc tgtacttcga gatcgagggc aaggacaagg acatctacat ctccaggctg     2580

gacttcgagt acatcaagcc gtaccaggag atctccaact acctgttcgc ctacttcgcc     2640

tcccagcaga tcaacgaggc cagggaggag gagcagatca accagaccaa gagggccctg     2700

gccggcaaca tgatcggcgt gatctactac ctgtaccaga agtacagggg catcatctcc     2760

atcgaggacc tgaagcagac caaggtggag tccgacagga acaagttcga gggcaacatc     2820

gagaggccgc tggagtgggc cctgtacagg aagttccagc aggagggcta cgtgccgccg     2880

atctccgagc tgatcaagct gagggagctg gagaagttcc cgctgaagga cgtgaagcag     2940

ccgaagtacg agaacatcca gcagttcggc atcatcaagt tcgtgtcccc ggaggagacc     3000

tccaccacct gcccgaagtg cctgaggagg ttcaaggact acgacaagaa caagcaggag     3060

ggcttctgca agtgccagtg cggcttcgac accaggaacg acctgaaggg cttcgagggc     3120

ctgaacgacc cggacaaggt ggccgccttc aacatcgcca agaggggctt cgaggacctg     3180

cagaagtaca agtccagggc cgacccgaag aagaagagga aggtgtga                  3228


<210>  107
<211>  3354
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 86ʾںϵ׵ı

<400>  107
atgctgatcc agttcaagaa ccactactcc tacaacaagt ccatcaggtt caagctggag       60

cacaagaacg gcaagctgcc gaagctggag tccgacaacg tggacctgaa caagctggtg      120

gacatcggca actccctgaa ggacatcttc gaggagctgg tgtacaccaa gaacaactac      180

aacaagctga actccctggt gtccatcaag aagcagtggc tgaagatcta cttcaagaac      240

gagttctact ccaacggcaa gatccagaac tactccctgt ccaacttctc ctacctgccg      300

aacaagctga tcgagtggct gaacaactgg cagaacaacc tgaaggccct gatcgagctg      360

accaagcagc aggacttcaa caagaccaag aagtccgaga tcgcctacat cctgtccctg      420

ttcaacggca agtactcctt ctccttcgtg aaggacttct ccacctgcat caaccacaag      480

aactcccagg agcagatcct gaagctgcag ggcgtggtgg agaacttcga gaaggtgctg      540

aacctgtgca tccaggagta cctgccgtcc aagtccgccg gcgtggtgat cgcccagggc      600

tccatgaact actacgccat caacaaggag ccgaagaggt acgacaacat cctggccgac      660

ctgaaccaga agttcgagga gctggacaag gagtacatcg ccatgaagca gtacaagtcc      720

tcccagaagt ccaggctgtt cgagttcatc aggaagggct tctccaagga ccagatcctg      780

tccgagttca agaagaagga gaacaacgag gtgtccttcg tgtacaacaa ccagatcatc      840

atcaggatct acacccagga gctgttcaag gactcctact gcctgggcga ggtgatcaag      900

ctgaccaaga agatcgagga gctgaacgag tccaaggact ccaacaacaa cctgccggag      960

gagaccaaga aggagatcac caagctgaag aaggagatcg gcttctactt catcaggagg     1020

accaggggca agtcccacaa caactacttc aagtcctact acggcttctg caacgacaag     1080

ttcaagaaga aggcccagga gaggggcagg ctgctgacca agatcaaggc catcaggaag     1140

gagaagatcg agtcccagaa cctgaggtac tggtccctga tcctggacga cggcaaggac     1200

aagttcctgt ggctggtgcc gaaggagaac atgcaggagt tcaggaggga gctgtccaag     1260

atccacccgt ccggcgagtc ctccctgttc ctgttccact ccctgaccat gagggccctg     1320

cacaagctgt gcttcgccca ggagtccgac ttcgtgaagg agatgccgaa ggtgctgaag     1380

gaggagcagc tgaactgcga gaaggcctcc aacgacaccg agaccaacaa gaggatcaag     1440

aggaacttcg gcctgaacta catcaagacc aaggacgagc tgaccctgtc cttcctgaag     1500

aagctgatca tctccgagta cgcccacgag aggctggacc tgaaccactt cgacctgtcc     1560

aagctgcagg tggccaccac cctgaacgag ttcgaggagt acctggagga cgcctgctac     1620

tacctggaga agatctccat ctcctcctcc atgatcaagg agctgctgga ggagtacaac     1680

atcctgaact tcaggatcac ctcctacgac ctggagaaga ggaacaagaa cacctaccag     1740

accccggagt ccgacatcaa gaggcacacc aaggagatct ggaacaagtt ctgggagggc     1800

gacaggttca tcaggctgaa cccggagatc aagatcaggt acaggcagaa gaaccagaac     1860

atcgaggact acctgaagga gaagggcttc gacctgacca agatcaagaa caggttcctg     1920

caggagcagt actccgtgtc cttcaccttc gccctgaacg ccggcaagaa gtacccgaag     1980

ctggccttcg tgaagaccga ggagatcctg gagaagatcg aggagttcaa cgacgagttc     2040

aacaagcagt acttcgacaa ctcctacaag tacggcatcg acaggggcaa catcgagctg     2100

gccaccctgt gcatcaccaa gttcaacaag aacgacacct acgagtacaa gggcaagaag     2160

tacctgaagc cgaacttccc gacctcccag gaggacatca agacctacga gctgaagaac     2220

gagtggtaca agaggaccgc catctccaac atcgagacca agccgaagaa caagaagacc     2280

ccgaagagga tcatcgccaa catctcctac ttcatcgaca acgtggagaa cgaggagtgg     2340

ttcaacaaga agacctgcac ctccatcgac ctgaccaccg ccaaggtgat caagggcaag     2400

ctgatcctga acggcgacgt gctgaccttc ctgaagctga agaaggaggc cgccaagagg     2460

atcctgttcg agctggtggc ccagaacaag ctgaccgcca agaacaagga gctgaagtgg     2520

aagtccgacg acggcaacaa ctccgactcc gtgaggctga tctgcgacgt gctggacaac     2580

gagaccaact ccatctactt ctacgaggac tccaagtacg gcaggggctt cgagggcctg     2640

ctgaccaccg acaagaccgc ctactccaag gagggcatca ggatcaacct gcagaactac     2700

ctgaaccacc tgatctccga gaaggagaac aagtccaaca aggcctactc ccacgtgccg     2760

tccatcgaga agatcaacca cctgagggac gccctggtgg ccaacatggt gggcgtgatc     2820

tcctacctgc aggcctacta cccgggcatc gtggtgctgg aggacctgaa ccacaagctg     2880

ctgatcaagc acttcgagga cctgaacatc aacatctcca acaggttcga gcacgccctg     2940

atcgagaagt tccagaccct gggcatggtg ccgccgcaca tcaaggacta cctggagatc     3000

aggtcctcct tcaggatgtc caggaacgac tcctcccagt tcggcgccct gatcttcgtg     3060

tccaaggagg gcacctccaa ggagtgcccg tactgcgaga agaagtggaa ctggggcaag     3120

gagaaggaga tcgagctgaa gttctccaag aagcagtaca tctgcggcaa ggagaactcc     3180

tgcggcttcg acaccaagca catccagaac accttcgagt tcctgtccga gatcaacgac     3240

ccggacaaga tcgccgccta caacatcgcc aagaggggct tcaagtcctt catcaacaag     3300

tcctccatca agaagcagtc cagggccgac ccgaagaaga agaggaaggt gtga           3354


<210>  108
<211>  3291
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 87ʾںϵ׵ı

<400>  108
atggagaagt acaagatcac caagaccatc aggttcaagc tgctgccgga caagatccag       60

gacatctcca ggcaggtggc cgtgctgcag aactccacca acgccgagaa gaagaacaac      120

ctgctgaggc tgatccagag gggccaggag ctgccgaagc tgctgaacga gtacatcagg      180

tactccgaca accacaagct gaagtccaac gtgaccgtgc acttcaggtg gctgaggctg      240

ttcaccaagg acctgttcta caactggaag aaggacaaca ccgagaagaa gatcaagatc      300

tccgacgtgg actacctgtc cagggtgttc gaggacttct tcaacgagtg ggagaccgtg      360

atcgagagga tcaacaccga ctgcaacagg ccggaggagt ccaagaccag ggacgccgag      420

atcgccttct ccatcaagaa gatcgccacc aagcagatgt tcccgttcat caagtccttc      480

gtgtacaact ccaactacaa gaactccgag gagaccaagt ccaagctgac cgccctgctg      540

aacgagttcg agaccgtgct gaagatctgc gagcagaact acctgccgtc ccagtccgcc      600

ggcatcgtga tcgccaaggc ctccttcaac tactacacca tcaacaagaa gcagaaggac      660

tacaagggct acaccgacga catcgagaag atcgagaagg gcatgaactc caagttccac      720

tacgagagga agtacgacca gctgctggag gagctgaacc tgatcgccct gaaggagctg      780

ccgctgatcg agttctactc caagatcaag tcctacaagt ccaccaggaa gatcgagttc      840

tccgaggccg tgtccaaggg cctggccttc gccgacctga agtccaagtt cccgctgttc      900

cagaccgagt ccaacaagta cgccgagttc ctggagctga ccggcaggat cacccagatc      960

tccaccgcca agtccctgct gtccaaggac aacccggagg cccagaagct gagggacgag     1020

atcaagaagc tgaggatcaa caggggcgag tacttcaaga acaacttcca caagtacatc     1080

tccctgtgca acctgtacaa gaagatcgcc gacaagaagg gcaggctgaa gggccaggtg     1140

aagggcatcg agaacgagag gatcgactcc cagaggatcc agcactgggc cctggtgctg     1200

gaggacaacc tgaagcactc cctgatcctg atcccgaagg agaaggtgac cgaggtgtac     1260

aggaaggtga gggcctccaa ggccgactcc acctcctcct cctcctccct gtactacttc     1320

gagtccatga cctacagggc cctgcacaag ctgtgcttcg gcgtgaacgg caacaccttc     1380

ctgccggaga tccagaagga gctgccggag tacaacccga acaagcagtc cgacttcggc     1440

gagttctgct tccacaagtc caacaccgac aaggagatcg acgagccgaa gctgatctcc     1500

ttctaccagt ccgtgctgaa gaccaactac gtgaaggaca acctgaacct gccgcagtcc     1560

gtgttcgacg aggccaccgt gcagaccttc gagaccaggc aggacttcca gatcgccctg     1620

gagaagtgct gctacgccaa gaagaccatc atctccgaga ccctgaagaa ggagatcctg     1680

gaggacaaca acgtgcagat cttccagatc acctccctgg acctgcagag gtccgagcag     1740

aagaacctga aggcccacac caagatctgg aacaggttct ggaccaagca gaacgagacc     1800

gccaactacg acctgaggct gaacccggag accgccatcg tgtggaggaa gccgaagaag     1860

accaggatcg acaagtacgg cgccggcacc tccctgtacg acccgaagaa gaggaacagg     1920

tacctgcacg agcagtacac cctgtgcacc accgtgaccg acaacgccct gaacaacgag     1980

atcaccttcg ccttcgagga caccaagaag aagggcaccg agatcgtgaa gtacaacgag     2040

aagatcaacc agaccctgaa gaaggagttc aacaagaacc agctgtggtt ctacggcatc     2100

gacgccggcg agatcgagct ggccaccctg gccctgatga acaaggacaa ggagccgcag     2160

ctgttcaccg tgtacgagct gaagaagtcc gacttcttca agcacggcta catctacaac     2220

aaggagaggg agctggtgat cagggagaag ccgtacaagg ccatccagaa cctgtcctac     2280

ttcctgaacg aggagctgta cgagaagacc ttcagggacg gcaagttcca ggagaccttc     2340

aacgagctgt tcaaggagaa gcacgtgtcc gccatcgacc tgaccaccgc caaggtgatc     2400

aacggcaaga tcatcctgaa cggcgacatg atcaccttcc tgaacctgag gatcctgcac     2460

gccaagagga agatctacga ggagctgatc atcaacccgc aggccgagct gaaggagaac     2520

gagaaggagt actacctgta cttcgacaag gagggcaccg agaaggtgga gaagatctac     2580

aggtccaggc tggacttcga gcacatcaag ccgtaccagg agatcaggaa cgacctgaac     2640

gcctacttca agaacgtgca gaagaacgag gccaaggtgg aggaccagat caaccagacc     2700

aggagggccc tggtgggcaa catgatcggc gtgatctact acctgtacca gaagtacagg     2760

ggcatcatct ccatcgagga cctgaagcag accaaggtgg agtccgacag gaacaagttc     2820

gagggcaaca tcgagaggcc gctggagtgg gccctgtaca ggaagttcca gcaggagggc     2880

tacgtgccgc cgatctccga gctgatcaag ctgagggagc tggagaagtt cccgctgaag     2940

gacgtgaagc agccgaagta cgagaacatc cagcagttcg gcatcatcaa gttcgtgtcc     3000

ccggaggaga cctccaccac ctgcccgtcc tgcgagaaga aggcctacga gctgcagaag     3060

gagaagaagg gcgaggagaa gccggccgag aacaagaggt acgaggccga caagaaggcc     3120

ggcgtgttct gctgcccgaa gtgcggcttc cacaacagga ccaacccgat gggctacgag     3180

tccctggact ccaacgacaa ggtggccgcc ttcaacatcg ccaagagggg cttcgaggac     3240

ctgcagaagc acaagtccag ggccgacccg aagaagaaga ggaaggtgtg a              3291


<210>  109
<211>  3135
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 88ʾںϵ׵ı

<400>  109
atggagaact ccaacctgta ccaggtggtg aagaccatca ggttcaagct ggagccggtg       60

ggcaagatgg acaccccgaa gttcggcgac aagaacgccg agtccaaggc caacctgacc      120

ccgttcatcg agctggtgaa gaagaccatg accaacgtga aggccctggt gttctccaag      180

caggacggcg aggacggcga gaagtggagg aagatcctgg aggtgaacta caggttcctg      240

aggtcctacc tgaagaactc cttctacgag aacaggggcg actcccagga gaagtccaag      300

aagcacaaga tctccgacct ggagtacctg cagaaggccc tggagaacct gttcgccgag      360

ttcgacgaga tcctggacgg cctggaggac ttcgagaaga ggaacaccaa gaaccagtac      420

gagaagcaga ggcacgccca ggccggcctg ctgctgaaca ggctgtgcaa gaggtccaac      480

ttcggcttcc tgaaggcctt cgtgggcgcc ctggcccaga ccaacaagcc gttcttcgac      540

gacaagaccg acaagctgaa gaagcagatc gacaagttcg agaccgagct ggagaagcag      600

aaggagttct tcctgccgta ccagtccaac ggcgtgctgt tcgccggcgg ctccttcaac      660

aggtacgcca tcaacaagac cccgaagatg ctggacaagg agctgaggga ggagcagacc      720

aacctgaaga agtccctgtg cgagcacaag atcaagatcg acaccctgaa caccctgggc      780

ctgaagaacg actgcccgtg cacctccctg gacaactcct acaccttcat caaggactac      840

aaggccaagc agaagtccaa gttcatcgag ctggtgcaga agggcgagtt cgacgaggcc      900

aagaaggtga acctgttcga gtgctccgag accgacttcg agaccttcaa gaccaggacc      960

aagcagatcc agaacgagaa ggacaaggac gagaggacca agctgaagca gaagaggggc     1020

gagttcttca agtcccagaa gaggggcaag ttcttcaagt cccagaccca gaactacgag     1080

aacctgtgcg acctgtacaa gaagatcgcc cagaagaggg gccagatcgt ggccaagatc     1140

tgcgccatca agaaggagaa ggagatgtgc gagcaggtga agtactggtg cgtggccctg     1200

gagaagggcg gcgagttcta cctgtacatg ttcctgaggg acgagaacga caacatcaag     1260

aacgcctacg acttcgtgtc caagctgcag acccagaagt ccggcgagac caagctgcac     1320

tacttcgact ccctgaccct gaaggccgtg aggaagctgt gcttcaagga gaccgacggc     1380

tccttcaaga aggccctgaa gaacgtgaag ttcccggagt gcgagcagaa cctggacgag     1440

aaggtgaaga tctccttcta ccagaacgtg ctgaagaacg ccaagaccct gaacctgtcc     1500

aagttcgaga acctgcagtc cgtgaccgag ggcaagttcg agtccctgtc cgagttcgag     1560

gtggccctga acatggtgtg ctacaccaag accgtgtgcg tgtccgagtc cgtggagaag     1620

gagctgaaga agttcaagcc gctggtgttc cacatcacct cccaggacct ggccgccaag     1680

agggagaaga aggcccacac ccagatctgg cacgagttct ggagggagtc caacgagaag     1740

tccaagttcc cgctgaggct gaacccggag ctgaaggtga tgtggaggga ggccaggccg     1800

tccagggtgg agaagtacgc cgagcagtcc gacaagttcg acccgaacaa gaagaacagg     1860

tacctgcacc cgcagttcac cctggccctg aacttcaccc agaacgccca caacgaggcc     1920

atcaacctgg ccttcaagga cgtgcagaac aagggcgagg ccgtgaagaa gttcaacgag     1980

aacttcaagt cctccgagta cgccttcggc atcgacgtgg gcaccaagga cctggccctg     2040

ctgtgcctga tcgacaagaa caagaagccg gtgaacttcg acgtgtacga gatctgcaac     2100

gagaacgaga tctgcaacga gaagctgggc ttcgagaagt tcggcttcta caaggacggc     2160

accaggaggg acgagccgta caagctgatc aagaacccgt cctacttcct gaacgagtcc     2220

ctgtacaaga agaccttcaa cgccaccaag gaggagttcg agaggtcctt ctccgagctg     2280

ttcaagagga agtccgtgtg cgccctggac ctgaccaccg ccaaggtgat ctgcggcaag     2340

atcatcctga acggcgactt ctccacccac ctgaacctga agatcctgaa cgccaagagg     2400

aagatctccg ccaagctgaa gaaggacccg accctgaaga tcgagtacga caacgacgac     2460

aacatcctgt tcggctccaa cgtgatcttc tactacaaca acaagtacga gatcgtgagg     2520

ccgtacgacg agatcaagaa cgagatcttc gagttccacg agaagcagag gctggacgac     2580

gccaggctgg aggacaacat caacaagacc agggccaacc tggtggccaa catggtgggc     2640

gtgatctcct tcctgcacaa ggagttctcc ggcttcgtgg tgctggagaa cctgaagcag     2700

tccgagatcg agggcaacca caggctgaag ttcgagggcg acatcaccag gccgctggag     2760

ctggccctgt acaggaagtt ccagtccaag tgcctgaccc cgccgatctc cgagctgatc     2820

aagctgaggg agggcgagaa gaacgagaac gtggagtccg acctgatcct gcagttcggc     2880

atcatcaagt tcgtggacaa ggacaagacc tccaggctgt gcccggcctg cggcaaggac     2940

gcctacgaga acaacaactc caagtacaag accgacaaga aggacggcgt gttcgagtgc     3000

gccggctgcg gcttcaacaa caagaacaac gccggcgact tcgccgccct ggacaccaac     3060

gacaagatcg ccaccttcaa catcgccaag aggggcctgt ccagggccga cccgaagaag     3120

aagaggaagg tgtga                                                      3135


<210>  110
<211>  3540
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 89ʾںϵ׵ı

<400>  110
atggagacct acaagatcac caagaccatc aggttcaagc tggaggccga cgaggagaac       60

tccatccaca tcaaggagga catcatcaac atcgagacca acgacaacga gttcaccatg      120

gtggacttcg tgtccaacct gggcaactac atcaaggacc tgaagaacta cctgttctac      180

gagaagaagg acggctccct gtccttcaag gacaagatca tcatcaagaa cgagtggctg      240

aggcagtacg ccaagcagga cttcgtggag ctgaagtcca agaagaggat caacctgagg      300

aacaacagga tggagcagat caagatcggc gacatcccga ggctgtcctc caagatcgag      360

gaggccctgg acatcgccaa ggagatctac tccaagctgt ccgacgacgc caccctggag      420

cagcacgaga ggaccaagaa ggcccagatc ggcctgctgc tgaagaggct ggaggccaag      480

aacgtgctgc cgctgctgat ggacctggtg aaggagaccc tggacaagga cgagaccgac      540

gacctgtcca tcaggctgaa gaggcagtcc cagaagatca actcccagct gaagatcgcc      600

atcaggtcct tcctgccgga gcagtccaac ggcctgcaga tcgccaaggc ctccttcaac      660

tactacacca tcaacaagaa gccgatcgac ttcgagaaga agatcgagga cctgaagaag      720

aacctgaacg tgaaggacct ggagaagctg aacgtgtact tcgacaagaa ggagaagaag      780

cagaagaact acctgggcaa gaagatcttc tccctgttcg agaccgacat ccagaaggcc      840

ctgtccaaga accagccgct gtacctgggc gacgccccga tgatcgactc cgcctacgtg      900

tccctgaggc agatcttcaa gaagatcaag tccgagcaga agaagcagtt ctccgagctg      960

atgcagaaca agtgctccta cgacgagctg aagaactcca acctgtacct gctgaacgac     1020

atcggcctgg agcagttcaa cacctacagg gagaagacca aggagctgga ggagctggcc     1080

accaagctgt ccaaccagaa cctgctggag aacgccaagg agaggctgag gtcccagaag     1140

gagaagatcg ccaaggagag gggcaacatc atgaaggaca ggttccagac ctggaagtcc     1200

ttcgccaact tctacaggac cgtgtcccag aagcacggca agatcctggc ccagctgaag     1260

ggcatcgaga aggagcaggc cgagtcccag ctgctgaagt actgggccct gatctgcgag     1320

aaggagaacc agcaccagct gtggctgatc ccgagggaga aggcctggga gtgcaagagg     1380

tggctggaga ccgtgaacga cacctccatc gacaacgaga actccatcaa gctgtactgg     1440

ttcgagtccc tgacctacag gtccctgcag aagctgtgct tcggcttcct ggagaacggc     1500

aacaacgagt tcaaccagaa catcaaggac ctgctgccga aggacaggat cggcaacacc     1560

atcaacggcg agttcgcctt cgagggcgac gaggagagga agatcgagtt ctacaagacc     1620

gtgctgaact ccaagtacgc caagcaggtg ctgaacatcc cgttcaagca ggtggaggag     1680

gagatcatct cccagtcctt cgagaacctg tccgacttcc agatcgccct ggagaagatc     1740

tgctacagga ggttcgccat ctactccaac tacatcatct ccttcgacgc ccagatcttc     1800

gacatcacct ccctggacct gaagaacaac gagaagaaca acctgaacac ccacacccac     1860

atctggaggg acttctggaa ggacgagaac gagaagaaca acttcgacat caggctgaac     1920

ccggagatca ccatctccta caggaccccg aagcagtcca ggatcgagaa gtacggcgag     1980

aagaccaagg agtacgaccc gaacaagaac aacaggtacc tgcacccgca gttcaccctg     2040

atcaccacca tctccgagag gtccaactcc cagaccaaga ccctgtcctt catcgaggac     2100

gaggacttca agaagtccat caacgagttc aacaagaagc tgaagaagga caacatcaag     2160

ttcgccttcg gcatcgacaa cggcgaggtg gagctgtcca ccctgggcgt gtacctgccg     2220

accttcgaga aggagaccca cgaggagaag atctacgagc tgaagcagat caagaagtac     2280

ggcttcgagg tgctgaccat caccgacctg aagtacaagg agaccgacta caacggcaac     2340

gtgaggaaga tcatccagaa cccgtcctac ttcctgaaga aggagaacta catcaggacc     2400

ttctccaagt ccgagcagga gtacgaggag atgttcgcca agctgttcaa gaaggagcac     2460

gtgctgtccc tggacctgac caccgccaag atgatctgcg gccacatcgt gaccaacggc     2520

gacgtgccgg ccctgttcaa cctgtggctg aagcacgccc agaggaacgt gttcgagatg     2580

aacgaccaca ccgtgaagga gaccgccaag accatcaggc tgaggaacaa cgaggagctg     2640

accgacaacg agaaggagaa gttcgccgag ttcatctccg acggcaagaa gttcgccaag     2700

ctgaccaagg agggcaagaa gtccaggtac ctgaagtgga tcttcgagga caggaaggag     2760

aactccttca ccgaggacga gaacaagaag ttcaacgact gccagaagaa gaagggcaag     2820

tacaactccc acatcatctt cgcctccagg ttcgagggcg acgagctgaa gtccgtgacc     2880

ccgatcttcg actgcaggca cgtgttcaag aagaggaagg agttcgagac catcaggccg     2940

atcaaggaga tcgagaacga gatctccagg ttcaacacca acaggacctc ccacaacatc     3000

tccaacgagg agctggacct gaagatcacc gacgccaaga aggccctggt ggccaacgcc     3060

atcggcgtga tcgacttcct gtacaagcag tacaagcaga ggttcaacga cgagggcctg     3120

atcatcaagg agggcttcga cacccagaag gtggaggagg acatcgagaa gttctccggc     3180

aacatctaca ggatcctgga gaggaagctg taccagaagt tccagaacta cggcctggtg     3240

ccgccgatca agaacctgat ggccgtgagg aacgagggca tcaaggacaa gaacgccatc     3300

ctgaggctgg gcaacatcgc cttcatcgac ccgtccggca cctcccagga gtgcccggtg     3360

tgcaaggaga agtccaagga gaagcacacc aacaacttca tctgcgagtg cggcttcaac     3420

tccaccaaca tcatgcactc caacgacggc atcgccggct tcaacatcgc caagaggggc     3480

ttcgagaact tcatcaacga gaagtccagg gccgacccga agaagaagag gaaggtgtga     3540


<210>  111
<211>  3597
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 90ʾںϵ׵ı

<400>  111
atggagaagt acaagatcac caagaccatc aggttcaggc tggacgccga caacaccgcc       60

atctccgcca tcgtgaagga caccgaggcc ctggaggcca ggggccaggg cttcaagatc      120

aagaagttcg tgaacgccct gggcaggttc ctgtccggcg acggcgtgca gaagtacctg      180

tacgacatgt ccaacgagga gaactgcgtg ttcaagagga acctggtgat caagaacacc      240

tggctgaaga acaacgccaa gcaggagatc gccggcatgg acctgaagag gggcctgatc      300

atcaaggaca tcaagggcct gcaggacaag atcgaggaga tctacgacaa gctgtgggag      360

atctacgaga tcctgtacga gtccgcctac ctgccgctgc aggacctggc caggagggag      420

ggcatcggcc tgctgctgaa gaagctgtcc gtgaagaacg ccctgccgtt catcatctcc      480

ttcgtggagg agtccaacga caagaacgag gccgacgacc tgtccctgag gctgaagaag      540

cagggcaagg agatcctgac ccagctggag atcggcatca acgagtacct gccggcccag      600

tcctccggcc tgccggtggc caaggcctcc ttcaactact acaccatcaa caagaccccg      660

gtggacttcg gcgagaagat ccaggagctg gagaagaggc tgtccgtgga catcaagaag      720

gagatctcct ccttcaccgg cggcatcaag accgccatca agaacaagat cgccggcaag      780

aagatcctgc tgggcgacac cccgatgttc gagtccgaga actccgtgtc cctgaggcag      840

atcctgaaga acatcaagtc cgagcagaag gcccagttca acaagttcat gaccacccag      900

aacaacccgc agctggagga gatgaagacc atgggctggt acctgttcgg cgacatcacc      960

gagggcgagt tcaacgacta caaggagcag accaaggaga tcgagagggt gggcgccaag     1020

atcaaccagt gcggcaacat caaggagaag aaggagctga ggtcccagct gcagaagctg     1080

aagaagaaga ggggcgagct gatctccgag gcccacaaga agggcggcaa cgacaagaac     1140

ttcaagacct acaaggagtt cgccaagttc tacaggaaga tcgcccagag gcacggcaag     1200

atcctggccc agatcaaggg catcgagaag gagaagatcg actccgccat gctgaactac     1260

tgggccgccg tgatcgagct gtccggcagg cacaagctgg tgctgatccc gaagaaggac     1320

gagaacgcca agaagtgcat cgagtggctg gaggacgagt ccaagcacaa gaacggctcc     1380

tgcaagatct tctggttcga gtccttcacc ttcaggtccc tgcagaagct gtgcttcggc     1440

aacctggact ccggcaccaa caccttcaac cagaagatcc agaacctgct gccgtgcgac     1500

gagaggggca acctgatgaa cggcgagttc gccttcaagg gcgacgagca ggagaagatc     1560

aagttctaca agaaggtgct gcagtcccag aaggacatca acctgccgca gaaggaggtg     1620

gtggacaacg tggtgggcag gaagttcgag accatggacg agttcaagat cgccctggag     1680

gagatctgct acatcaggag ggagaggctg tccgccaacg ccgagtccga gctgaagtcc     1740

aagttcaacg cccagatctt cgacatcacc tccctggacc tgaggaaccc ggtgaactgc     1800

gccggcaagc cggaggtgta ccaccacaac gacaagaggc acaccgagat ctggaaggag     1860

ttctggtccc tggacaacga gaggaggaac ttcaacatca ggctgaaccc ggagatcacc     1920

atcacctaca ggaagccgaa ggagtccagg atcctgaagt acggcaaggg caccgagaag     1980

tacaacgccg acatgaagaa caggtacctg tacccgcagt acaccctgct gaccaccatc     2040

tccgagcact gcaacacccc gaccaagatc ctgtccttca tgaccgacaa cgagtacgag     2100

gagtccatca aggccttcaa ctccaagctg aagaaggagg acatcaagtt cgccttcggc     2160

atcgactccg gcgagaccga gctgtccacc ctgggcgtgt acctgccgga gttctccgcc     2220

gagtccaccg agctgaagga catcgagaag tacggcttca acgtgctgac catcaaggac     2280

ctgaactaca ccgagaccga ctacaacggc tccgacaaga agatcgtgaa gaacccgtcc     2340

tacttcgtgg acaagtccct gtacatgagg accttcaaga agaccgagca ggagtacgag     2400

aagatgttcg ccgagcagtt cgaggccaag aagaggctgt ccctggacct gtccgccgcc     2460

aaggtgatct gcggccacat cgtgaccaac ggcggcgtgt ccgagcactt cggcctgtgg     2520

ctgaagcacg cccagaggac catcttctgg atgaacgacc acaccgagaa gaagaccgcc     2580

aagaacatca agctgaagga ctcctccgag ctgacctacg acgagaggga gaagttcgcc     2640

gagcacatct cctccgacga gaagttcaag aagctggacg tggaggagaa gaagaggtac     2700

gtgaggtgga tcttcgagga cagggagacc ctgaacttca ccgaggccga gaacaagaag     2760

ttcggcggct accagaagaa gaagggcgac tacaggctgg gcatcctgtt cgcctcctgc     2820

ttcatcggca aggagctgga gtccgtgacc cagatcctgg actgcaggca catcttcaag     2880

aagagggagg agttctactc cctgaagtcc aaggaggaca tcgaggccga gatcaagagg     2940

tacaacaccg actacaccaa ccacaacatc tccaccgagc agctggacct gaagttcgtg     3000

aacgtgaaga acgccctggt ggccaacgcc gtgggcgtga tcgacctgct gtacaagcag     3060

tacaaggaga ggctgggcgg cgagggcctg atcgccaagg agggcttcga caccaagaag     3120

gtggaggagg acatggagaa gttctccggc aacatctaca ggatcctgga gaggaagctg     3180

taccagaagt tccagaacta cggcctggtg ccgccgatca agaacctgat ggccgtgagg     3240

gccgacaagg tggagatctc cgaggccgag aagtccaaga tcagggagaa ctgcaagatc     3300

tccaagatcg acccggagaa cgagatcatc aagaggaaca agaccctgat cctgaggctg     3360

ggctccatcg ccttcgtgaa cgacgccgac acctcccagg agtgcccggc ctgcggcacc     3420

aagtccaagg agaagcacgt ggacaacttc atctgcggct gcggcttcaa ctccaccggc     3480

atcatccact ccaacgacgg cgtggccggc ttcaacatcg ccaagagggg cttcgtgaac     3540

ctgatggagc acgagctgag gtccagggcc gacccgaaga agaagaggaa ggtgtga        3597


<210>  112
<211>  3621
<212>  DNA
<213>  ˹

<220>
<223>  SEQ ID NO: 91ʾںϵ׵ı

<400>  112
atggagaagt acaagctgac caagaccatc aggttcaagc tgaagccgaa ggacatctcc       60

gccatcaaga gggacgtgga ggccctggag cagcagaagt tcgacctggt gctgttcgtg      120

tacaacctgc acaacttcat cggcaagctg aaggagtacc tgttcttcca gaaggagaag      180

gacgagttcg tgatcaagga caagctgacc atcaagaaga cctggctgaa gcagtacgcc      240

aagcaggaga tcgccggcct ggagctgaac agggagcaga ccctgggcaa catcaagggc      300

gtgtccgcca ggatcgagag ggccgtggac gacgtgaaca agatctacgt ggagctggcc      360

atggaggcca agctgaacga gagggccaag aaggccaaga ccgagcagct gatcaagagg      420

ctggacacca ggaacgccct gccgctgctg gtgtccctga tcgagcagtc ctccgacaag      480

tacgagaccg gcaacctgtc catccagctg aagaggctgg gcaagaggct gcagacccag      540

ctgctgtccg gcatcaagaa gtacctggcc gagcagtcca acggcctgcc gatcgccaag      600

gcctccttca actactacgc catcaacaag aagccggtgg actacatcga caagatcaag      660

cagctgcaga aggacctgga gatcaagaag aacaggaggt ccgaggagag gtacgacaag      720

aagaagagga agaacatcaa gatcttcaac gactccaagc tgtggatcaa gatcaagaag      780

gacatcgaga aggagagggg caacaagacc ctgatcctgg gctacgcccc gatgatcgag      840

ccgggcaact acgtgtacct gaggcagatc ctgaagaaca tcaagctgga gcagaagaac      900

aagttctcca agctgatgca gtccaagtcc ctgaccttcc acgacctgaa caacaacaac      960

cagctgtacc tgttcaagga catcctggag ggcgagttca acaagtacaa gcagaagacc     1020

aacgagatcg agaccaaggc cgagaagagg aaccagtgca acaacgacga gctgaagagg     1080

aagctgaact ccgagctgca gcagctgagg aaggacaggg gctccctgat caacgccgcc     1140

gacggcaggc cgaagggcag gttcaagacc tacaagtact tcgccaactt ctacaggaac     1200

gtggcccaga agcacggcag gatcctgtcc accctgaagg gcatcgagaa ggagatggtg     1260

gagtcccagc tgctgaagta ctggaccatc atcaccgagg agaacaacca gcactccctg     1320

gtgctgatcc cgaaggagag ggccggcgag tacaagaagg acctggagaa ctccatcccg     1380

tccgacccgt cctccaagat caaggtgtac tggttcgagt ccttcaccct gaggtccctg     1440

aggaagctgt gcttcggcta cgtgaacaac aacaccggct ccaacacctt ctacccggag     1500

ctgaagaagt ccgacgagct gaggaagtac cacgacgaga ggggcaactt catcaagggc     1560

gagttctact tcaagggcga cgagcagaag atcatccagt tctacaagga cgtgctgagg     1620

tccaactacg cccagaaggt gctgaagttc ccgaagcagc aggtgaagga cgagctgatc     1680

ggcagggagt tctcctccct ggacgagttc cagatcgccc tggagaagat ctgctaccag     1740

aggcacgtgg tgtgctccca gaaggtggtg gacgccctgt ccaggtacaa cgcccagatc     1800

ttcctgatca cctccctgga cctgggcaac ccggccaact gcgtggacaa gccgaagcag     1860

ttctcccact tcgacaagaa gcacaccagg atctggaagg agttctggtc ctccaagaac     1920

gagaccgcca acttcgacat caggctgaac ccggagatcg tgatcaccta caggcagccg     1980

aagcagtcca ggatcaagaa gtacggcccg gagtccacca ggtacgacga caggaagcac     2040

aacaggtacc tgtacccgca gttcaccctg atcaccacca tctccgagta ctccaacgcc     2100

ccgaccaagg ccctgtcctt cctgaccgac gaggagttca agggcgccgt ggacgagttc     2160

aacaagaagt tcaagaagga gaacatcagg ttctccctgg gcatcgacaa cggcgagacc     2220

gagctgtcca ccctgggcgt gtacctgccg gtgttcaaga aggactccaa cgagaaggtg     2280

gtggccgagc tgaagaaggt gaacaagtac ggcttcaact tcctgaccat caaggacctg     2340

tcccacgtgg agaaggacaa gaacggcagg gtgaggaaga tcatccagaa cccgtcctac     2400

ttcctgtcca aggagcagta catgaggacc ttcggcagga ccgagcagga gtacaacaac     2460

atgttcgccg agcagttcga ggagaaggcc ttcctgtccc tggacctgac caccgccaag     2520

gtgatcaacg gccacatcgt gaccaacggc gacgtgccga ccttcctgaa cctgtggatg     2580

aggcacgccc agagggacat ctgggacatg aacgaccaca ccaaggagaa gaccgccaag     2640

aagatcgtga tcaagaacaa cgacgagctg accgacgccg agaaggtgaa gttcgtggag     2700

tacatctccg acgagaccaa ctacgccaag ctgaacttca acgagaagaa gaggtacgtg     2760

ctgtggatct tcgagaacag gaagaacatc aacttcaccg acgccgagaa gaagaagttc     2820

gagccgtgcc agaagaggaa gggcaacttc tccaaggaca tcctgttcgc cgtgtgctac     2880

atcggctccg agatccactc cgtgaccaac atcttcgacg tgaggaacat cttcaagatg     2940

aggaaggact tctacgtgct gaagtccgag atggagatca agaaggagat cgagtcctac     3000

aacaccaccg ccggcatcca ggagatctcc aacgaggagc tggacctgaa gatcaacagg     3060

ctgaagcagg ccgtggtggc caacgccgtg ggcgtgatcg actacctgta catctactac     3120

aagaagaaga ccggcggcga gggcctgatc atcaaggagg gcttcgacac caagaaggtg     3180

gccaaggccc tggagaagtt ctccggcaac atctacagga tcctggagag gaagctgtac     3240

cagaagttcc agaactacgg cctggtgccg ccgatcaagt ccctgatggc cgtgagggag     3300

gagggcatcg agaacaacaa ggacgccatc ctgaggctgg gcaacgtggg cttcatcgac     3360

ccgaccggca cctcccagca gtgcccggtg tgctccaagg gcaagctgaa ccacaccacc     3420

aagtgctcca agaactgcgg cttcaactcc aagaacatca tgcactccaa cgacggcatc     3480

gccggctaca acatcgccaa gaggggcttc gagaacttca tctcccagaa gaagggctac     3540

gacgtgatca acaacggcac caagtacaac aacctgaagt cccagtccag ggccgacccg     3600

aagaagaaga ggaaggtgtg a                                               3621


