                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Gill, Saar
       Payne, Aimee
       Hogan, Jonathan
       Wang, Baomei
 
<120>  COMPOSITIONS AND METHODS OF PHOSPHOLIPASE A2 RECEPTOR  CHIMERIC 
       AUTOANTIBODY RECEPTOR T CELLS

<130>  046483-7207WO1(02014)

<150>  62/665,863
<151>  2018-05-02

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR (Ricin B type lectin) domain

<400>  1
aagggcatct tcgtgatcca gagcgagagc ctgaagaagt gcatccaggc cggcaagagc       60

gtgctgaccc tggaaaattg caagcaggcc aacaagcaca tgctgtggaa atgggtgtcc      120

aaccacggcc tgttcaacat cggcggctct ggatgtctgg gcctgaattt ctctgcccct      180

gagcagcctc tgagcctgta cgagtgtgat agcaccctgg tgtccctgag atggcggtgc      240

aaccggaaga tgatcacagg ccctctgcag tactctgtgc aggtcgccca cgacaatacc      300

gtggtggcca gcagaaagta catccacaag tggatcagct acggcagcgg cggaggcgac      360

atctgtgaat ac                                                          372


<210>  2
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2
ctgcacaagg atctgcacac catcaagggc aac                                    33


<210>  3
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fibronectin type-2 domain

<400>  3
acccacggaa tgccctgcat gttcccgttt cagtacaacc accagtggca ccacgagtgc       60

accagagaag gcagagagga cgacctgctt tggtgcgcca caaccagcag atacgagcgg      120

gatgagaagt ggggcttctg ccctgat                                          147


<210>  4
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4
cctacctctg ccgaagtggg ctgcgatacc atctgggaga aagacctg                    48


<210>  5
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-type lectin domain 1

<400>  5
aacagccaca tctgctacca gttcaacctg ctgtccagcc tgtcttggag cgaggcccac       60

agcagctgtc aaatgcaagg cggcacactg ctgagcatca ccgacgagac agaggaaaac      120

ttcatccgcg agcacatgag cagcaagacc gtggaagtgt ggatgggact gaaccagctg      180

gatgagcatg ccggatggca gtggagtgat ggcacccctc tgaactacct gaactggtcc      240

cctgaagtga acttcgagcc cttcgtggaa gatcactgcg gcaccttcag cagcttcatg      300

cccagcgctt ggagaagcag agactgcgag agcaccctgc cttacatctg caag            354


<210>  6
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  6
aagtacctga accacatcga ccacgagatc gtggaaaagg acgcctggaa gtactacgcc       60

acacactgcg agcctggctg gaacccc                                           87


<210>  7
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-type lectin domain 2

<400>  7
tacaaccgga actgctacaa gctgcagaaa gaggaaaaga cctggcacga ggccctgaga       60

agctgccagg ccgataatag cgccctgatc gacatcacaa gcctggccga ggtggaattt      120

ctggtcactc tgctgggcga cgagaacgcc tctgagacat ggatcggcct gtccagcaac      180

aagatccccg tgtccttcga gtggtccaac gacagcagcg tgatcttcac caactggcac      240

accctggaac ctcacatctt ccccaacaga tcccagctgt gtgtgtccgc cgagcagtct      300

gaaggccact ggaaagtgaa gaactgcgag gaacggctgt tctacatctg taaa            354


<210>  8
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domains of Construct 4027.CF12

<400>  8
aagggcatct tcgtgatcca gagcgagagc ctgaagaagt gcatccaggc cggcaagagc       60

gtgctgaccc tggaaaattg caagcaggcc aacaagcaca tgctgtggaa atgggtgtcc      120

aaccacggcc tgttcaacat cggcggctct ggatgtctgg gcctgaattt ctctgcccct      180

gagcagcctc tgagcctgta cgagtgtgat agcaccctgg tgtccctgag atggcggtgc      240

aaccggaaga tgatcacagg ccctctgcag tactctgtgc aggtcgccca cgacaatacc      300

gtggtggcca gcagaaagta catccacaag tggatcagct acggcagcgg cggaggcgac      360

atctgtgaat acctgcacaa ggatctgcac accatcaagg gcaacaccca cggaatgccc      420

tgcatgttcc cgtttcagta caaccaccag tggcaccacg agtgcaccag agaaggcaga      480

gaggacgacc tgctttggtg cgccacaacc agcagatacg agcgggatga gaagtggggc      540

ttctgccctg atcctacctc tgccgaagtg ggctgcgata ccatctggga gaaagacctg      600

aacagccaca tctgctacca gttcaacctg ctgtccagcc tgtcttggag cgaggcccac      660

agcagctgtc aaatgcaagg cggcacactg ctgagcatca ccgacgagac agaggaaaac      720

ttcatccgcg agcacatgag cagcaagacc gtggaagtgt ggatgggact gaaccagctg      780

gatgagcatg ccggatggca gtggagtgat ggcacccctc tgaactacct gaactggtcc      840

cctgaagtga acttcgagcc cttcgtggaa gatcactgcg gcaccttcag cagcttcatg      900

cccagcgctt ggagaagcag agactgcgag agcaccctgc cttacatctg caagaagtac      960

ctgaaccaca tcgaccacga gatcgtggaa aaggacgcct ggaagtacta cgccacacac     1020

tgcgagcctg gctggaaccc ctacaaccgg aactgctaca agctgcagaa agaggaaaag     1080

acctggcacg aggccctgag aagctgccag gccgataata gcgccctgat cgacatcaca     1140

agcctggccg aggtggaatt tctggtcact ctgctgggcg acgagaacgc ctctgagaca     1200

tggatcggcc tgtccagcaa caagatcccc gtgtccttcg agtggtccaa cgacagcagc     1260

gtgatcttca ccaactggca caccctggaa cctcacatct tccccaacag atcccagctg     1320

tgtgtgtccg ccgagcagtc tgaaggccac tggaaagtga agaactgcga ggaacggctg     1380

ttctacatct gtaaa                                                      1395


<210>  9
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  9
aaggccggcc acgtgctgtc cgatgccgag agtggatgtc aatccgga                    48


<210>  10
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  10
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gt                                                          132


<210>  11
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4027.CF12

<400>  11
atgctgctga gccctagcct gctgctgctc ctgcttcttg gagcccctag aggatgtgcc       60

ggatctgaag gtgttgccgc cgctctgaca cccgagagac tgctggaatg gcaggacaag      120

ggcatcttcg tgatccagag cgagagcctg aagaagtgca tccaggccgg caagagcgtg      180

ctgaccctgg aaaattgcaa gcaggccaac aagcacatgc tgtggaaatg ggtgtccaac      240

cacggcctgt tcaacatcgg cggctctgga tgtctgggcc tgaatttctc tgcccctgag      300

cagcctctga gcctgtacga gtgtgatagc accctggtgt ccctgagatg gcggtgcaac      360

cggaagatga tcacaggccc tctgcagtac tctgtgcagg tcgcccacga caataccgtg      420

gtggccagca gaaagtacat ccacaagtgg atcagctacg gcagcggcgg aggcgacatc      480

tgtgaatacc tgcacaagga tctgcacacc atcaagggca acacccacgg aatgccctgc      540

atgttcccgt ttcagtacaa ccaccagtgg caccacgagt gcaccagaga aggcagagag      600

gacgacctgc tttggtgcgc cacaaccagc agatacgagc gggatgagaa gtggggcttc      660

tgccctgatc ctacctctgc cgaagtgggc tgcgatacca tctgggagaa agacctgaac      720

agccacatct gctaccagtt caacctgctg tccagcctgt cttggagcga ggcccacagc      780

agctgtcaaa tgcaaggcgg cacactgctg agcatcaccg acgagacaga ggaaaacttc      840

atccgcgagc acatgagcag caagaccgtg gaagtgtgga tgggactgaa ccagctggat      900

gagcatgccg gatggcagtg gagtgatggc acccctctga actacctgaa ctggtcccct      960

gaagtgaact tcgagccctt cgtggaagat cactgcggca ccttcagcag cttcatgccc     1020

agcgcttgga gaagcagaga ctgcgagagc accctgcctt acatctgcaa gaagtacctg     1080

aaccacatcg accacgagat cgtggaaaag gacgcctgga agtactacgc cacacactgc     1140

gagcctggct ggaaccccta caaccggaac tgctacaagc tgcagaaaga ggaaaagacc     1200

tggcacgagg ccctgagaag ctgccaggcc gataatagcg ccctgatcga catcacaagc     1260

ctggccgagg tggaatttct ggtcactctg ctgggcgacg agaacgcctc tgagacatgg     1320

atcggcctgt ccagcaacaa gatccccgtg tccttcgagt ggtccaacga cagcagcgtg     1380

atcttcacca actggcacac cctggaacct cacatcttcc ccaacagatc ccagctgtgt     1440

gtgtccgccg agcagtctga aggccactgg aaagtgaaga actgcgagga acggctgttc     1500

tacatctgta aaaaggccgg ccacgtgctg tccgatgccg agagtggatg tcaatccgga     1560

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     1620

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg     1680

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc     1740

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1800

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1860

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1920

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1980

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     2040

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     2100

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     2160

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     2220

ccccctcgct aa                                                         2232


<210>  12
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4027.CF12

<400>  12

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Gly Ser Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp 
    370                 375                 380                 


Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr 
385                 390                 395                 400 


Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile 
                405                 410                 415     


Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp 
            500                 505                 510         


Ala Glu Ser Gly Cys Gln Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
        515                 520                 525             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    530                 535                 540                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
545                 550                 555                 560 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                565                 570                 575     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            580                 585                 590         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        595                 600                 605             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    610                 615                 620                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
625                 630                 635                 640 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                645                 650                 655     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            660                 665                 670         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        675                 680                 685             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    690                 695                 700                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
705                 710                 715                 720 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                725                 730                 735     


Met Gln Ala Leu Pro Pro Arg 
            740             


<210>  13
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13
aaggccggcc acgtgctgtc cgatgccgag agtggatgtc aagaaggctg ggagaga          57


<210>  14
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CC-type lectin domain 3

<400>  14
cacggcggct tttgctacaa gatcgacacc gtgctgcgga gcttcgatca ggccagcagc       60

ggctactatt gccctcctgc tctggtcacc atcaccaaca gattcgagca ggccttcatc      120

accagcctga tcagcagcgt cgtgaagatg aaggacagct acttctggat cgccctgcag      180

gaccagaacg acaccggcga gtacacatgg aagcccgtgg gacagaaacc cgagcctgtg      240

cagtacaccc actggaacac acaccagcct agatactccg gcggctgcgt ggcaatgaga      300

ggcagacatc ctctcggcag atgggaagtg aagcactgtc ggcacttcaa ggccatgtct      360

ctgtgc                                                                 366


<210>  15
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domains of PLA2R Construct 4028.CF123

<400>  15
aagggcatct tcgtgatcca gagcgagagc ctgaagaagt gcatccaggc cggcaagagc       60

gtgctgaccc tggaaaattg caagcaggcc aacaagcaca tgctgtggaa atgggtgtcc      120

aaccacggcc tgttcaacat cggcggctct ggatgtctgg gcctgaattt ctctgcccct      180

gagcagcctc tgagcctgta cgagtgtgat agcaccctgg tgtccctgag atggcggtgc      240

aaccggaaga tgatcacagg ccctctgcag tactctgtgc aggtcgccca cgacaatacc      300

gtggtggcca gcagaaagta catccacaag tggatcagct acggcagcgg cggaggcgac      360

atctgtgaat acctgcacaa ggatctgcac accatcaagg gcaacaccca cggaatgccc      420

tgcatgttcc cgtttcagta caaccaccag tggcaccacg agtgcaccag agaaggcaga      480

gaggacgacc tgctttggtg cgccacaacc agcagatacg agcgggatga gaagtggggc      540

ttctgccctg atcctacctc tgccgaagtg ggctgcgata ccatctggga gaaagacctg      600

aacagccaca tctgctacca gttcaacctg ctgtccagcc tgtcttggag cgaggcccac      660

agcagctgtc aaatgcaagg cggcacactg ctgagcatca ccgacgagac agaggaaaac      720

ttcatccgcg agcacatgag cagcaagacc gtggaagtgt ggatgggact gaaccagctg      780

gatgagcatg ccggatggca gtggagtgat ggcacccctc tgaactacct gaactggtcc      840

cctgaagtga acttcgagcc cttcgtggaa gatcactgcg gcaccttcag cagcttcatg      900

cccagcgctt ggagaagcag agactgcgag agcaccctgc cttacatctg caagaagtac      960

ctgaaccaca tcgaccacga gatcgtggaa aaggacgcct ggaagtacta cgccacacac     1020

tgcgagcctg gctggaaccc ctacaaccgg aactgctaca agctgcagaa agaggaaaag     1080

acctggcacg aggccctgag aagctgccag gccgataata gcgccctgat cgacatcaca     1140

agcctggccg aggtggaatt tctggtcact ctgctgggcg acgagaacgc ctctgagaca     1200

tggatcggcc tgtccagcaa caagatcccc gtgtccttcg agtggtccaa cgacagcagc     1260

gtgatcttca ccaactggca caccctggaa cctcacatct tccccaacag atcccagctg     1320

tgtgtgtccg ccgagcagtc tgaaggccac tggaaagtga agaactgcga ggaacggctg     1380

ttctacatct gtaaaaaggc cggccacgtg ctgtccgatg ccgagagtgg atgtcaagaa     1440

ggctgggaga gacacggcgg cttttgctac aagatcgaca ccgtgctgcg gagcttcgat     1500

caggccagca gcggctacta ttgccctcct gctctggtca ccatcaccaa cagattcgag     1560

caggccttca tcaccagcct gatcagcagc gtcgtgaaga tgaaggacag ctacttctgg     1620

atcgccctgc aggaccagaa cgacaccggc gagtacacat ggaagcccgt gggacagaaa     1680

cccgagcctg tgcagtacac ccactggaac acacaccagc ctagatactc cggcggctgc     1740

gtggcaatga gaggcagaca tcctctcggc agatgggaag tgaagcactg tcggcacttc     1800

aaggccatgt ctctgtgc                                                   1818


<210>  16
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  16
aagcagcccg tggaaaatca agagaaggcc gagtacgagg aacgctggcc ttttcaccct       60

tgctacctgt ccgga                                                        75


<210>  17
<211>  2682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4028.CF123

<400>  17
atgctgctga gccctagcct gctgctgctc ctgcttcttg gagcccctag aggatgtgcc       60

ggatctgaag gtgttgccgc cgctctgaca cccgagagac tgctggaatg gcaggacaag      120

ggcatcttcg tgatccagag cgagagcctg aagaagtgca tccaggccgg caagagcgtg      180

ctgaccctgg aaaattgcaa gcaggccaac aagcacatgc tgtggaaatg ggtgtccaac      240

cacggcctgt tcaacatcgg cggctctgga tgtctgggcc tgaatttctc tgcccctgag      300

cagcctctga gcctgtacga gtgtgatagc accctggtgt ccctgagatg gcggtgcaac      360

cggaagatga tcacaggccc tctgcagtac tctgtgcagg tcgcccacga caataccgtg      420

gtggccagca gaaagtacat ccacaagtgg atcagctacg gcagcggcgg aggcgacatc      480

tgtgaatacc tgcacaagga tctgcacacc atcaagggca acacccacgg aatgccctgc      540

atgttcccgt ttcagtacaa ccaccagtgg caccacgagt gcaccagaga aggcagagag      600

gacgacctgc tttggtgcgc cacaaccagc agatacgagc gggatgagaa gtggggcttc      660

tgccctgatc ctacctctgc cgaagtgggc tgcgatacca tctgggagaa agacctgaac      720

agccacatct gctaccagtt caacctgctg tccagcctgt cttggagcga ggcccacagc      780

agctgtcaaa tgcaaggcgg cacactgctg agcatcaccg acgagacaga ggaaaacttc      840

atccgcgagc acatgagcag caagaccgtg gaagtgtgga tgggactgaa ccagctggat      900

gagcatgccg gatggcagtg gagtgatggc acccctctga actacctgaa ctggtcccct      960

gaagtgaact tcgagccctt cgtggaagat cactgcggca ccttcagcag cttcatgccc     1020

agcgcttgga gaagcagaga ctgcgagagc accctgcctt acatctgcaa gaagtacctg     1080

aaccacatcg accacgagat cgtggaaaag gacgcctgga agtactacgc cacacactgc     1140

gagcctggct ggaaccccta caaccggaac tgctacaagc tgcagaaaga ggaaaagacc     1200

tggcacgagg ccctgagaag ctgccaggcc gataatagcg ccctgatcga catcacaagc     1260

ctggccgagg tggaatttct ggtcactctg ctgggcgacg agaacgcctc tgagacatgg     1320

atcggcctgt ccagcaacaa gatccccgtg tccttcgagt ggtccaacga cagcagcgtg     1380

atcttcacca actggcacac cctggaacct cacatcttcc ccaacagatc ccagctgtgt     1440

gtgtccgccg agcagtctga aggccactgg aaagtgaaga actgcgagga acggctgttc     1500

tacatctgta aaaaggccgg ccacgtgctg tccgatgccg agagtggatg tcaagaaggc     1560

tgggagagac acggcggctt ttgctacaag atcgacaccg tgctgcggag cttcgatcag     1620

gccagcagcg gctactattg ccctcctgct ctggtcacca tcaccaacag attcgagcag     1680

gccttcatca ccagcctgat cagcagcgtc gtgaagatga aggacagcta cttctggatc     1740

gccctgcagg accagaacga caccggcgag tacacatgga agcccgtggg acagaaaccc     1800

gagcctgtgc agtacaccca ctggaacaca caccagccta gatactccgg cggctgcgtg     1860

gcaatgagag gcagacatcc tctcggcaga tgggaagtga agcactgtcg gcacttcaag     1920

gccatgtctc tgtgcaagca gcccgtggaa aatcaagaga aggccgagta cgaggaacgc     1980

tggccttttc acccttgcta cctgtccgga accacgacgc cagcgccgcg accaccaaca     2040

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     2100

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg     2160

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     2220

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     2280

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     2340

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     2400

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     2460

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     2520

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     2580

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     2640

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        2682


<210>  18
<211>  893
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4028.CF123

<400>  18

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Gly Ser Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp 
    370                 375                 380                 


Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr 
385                 390                 395                 400 


Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile 
                405                 410                 415     


Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp 
            500                 505                 510         


Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser 
                565                 570                 575     


Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr 
            580                 585                 590         


Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp 
        595                 600                 605             


Asn Thr His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly 
    610                 615                 620                 


Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys 
625                 630                 635                 640 


Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu 
                645                 650                 655     


Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Ser Gly Thr Thr 
            660                 665                 670         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        675                 680                 685             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    690                 695                 700                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
705                 710                 715                 720 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                725                 730                 735     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            740                 745                 750         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        755                 760                 765             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    770                 775                 780                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
785                 790                 795                 800 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                805                 810                 815     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            820                 825                 830         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        835                 840                 845             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    850                 855                 860                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
865                 870                 875                 880 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                885                 890             


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  19

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  20
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  20
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  21
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  21

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  22
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  22
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  23

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  24
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  24
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  25
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct C

<400>  25
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggaa tatttgtcat tcagtcagag tctttgaaaa agtgcataca ggctggaaaa      120

agcgtgctta ccctggagaa ctgcaagcaa gctaataagc atatgctttg gaaatgggtt      180

agcaaccacg gactctttaa tatcggaggc tccggctgtc tgggcctgaa cttcagtgca      240

ccggagcaac cgctttctct gtacgaatgt gatagcacac ttgttagtct tcggtggcgg      300

tgtaaccgaa aaatgattac aggccctctg caatatagtg ttcaagtggc ccacgacaat      360

acagttgtgg cgtctagaaa atatattcac aagtggattt cctacgggag cggcggaggg      420

gatatatgtg aatatcttca caaagacttg catacaatcg ctagcttcgt gccggtcttc      480

ctgccagcga agccaaccac gacgccagca ccgcgaccac caacacctgc gcccaccatc      540

gcgtcgcagc ccctgtccct gcgcccagag gcgtgcagac cagcagcggg gggcgcagtg      600

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      660

tgtggggtcc ttctcctgtc actggttatc accctttact gcaagcgcgg tcgcaagaaa      720

ctgctctata tttttaaaca gccattcatg agacctgtcc agaccactca agaggaggac      780

ggatgttcct gtagatttcc tgaagaggaa gagggggggt gcgagctgag agtgaagttc      840

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      900

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      960

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1020

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1080

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1140

cacatgcagg ccctgccccc tcgctaa                                         1167


<210>  26
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct C

<400>  26

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Ala Ser Phe Val Pro Val Phe 
145                 150                 155                 160 


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                165                 170                 175     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            180                 185                 190         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        195                 200                 205             


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
    210                 215                 220                 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                245                 250                 255     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            260                 265                 270         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        275                 280                 285             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    290                 295                 300                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
305                 310                 315                 320 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                325                 330                 335     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            340                 345                 350         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        355                 360                 365             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    370                 375                 380                 


Leu Pro Pro Arg 
385             


<210>  27
<211>  1761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR construct CF1

<400>  27
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggga tctttgttat acaaagtgag agcttgaaaa aatgtataca ggctggcaaa      120

agtgtactga ctcttgaaaa ttgcaaacaa gccaacaaac acatgctgtg gaaatgggtg      180

tctaatcacg gtctcttcaa tattggggga agtggatgcc tcggcctgaa tttctccgct      240

cccgaacagc ccctctcact ttatgagtgt gattcaactc tggtgtcctt gaggtggcga      300

tgtaaccgca agatgataac cggccccctc cagtattccg tccaagtagc acacgacaat      360

accgtggtgg catctaggaa atacattcat aagtggatat cttatggcag tggtggcggt      420

gacatatgcg agtacctgca caaggacctc cacacaataa aggggaacac gcacgggatg      480

ccgtgtatgt tcccgttcca atataatcat caatggcacc atgagtgtac gagagagggg      540

cgagaagacg acctcctgtg gtgtgcgacc acctcaagat atgaacggga tgagaagtgg      600

ggcttttgcc ccgacccaac ctccgccgag gttggttgcg acactatttg ggaaaaagat      660

ttgaacagtc atatatgcta tcaatttaat ttgttgagtt cactctcctg gagcgaagcg      720

cacagctctt gtcagatgca aggtggtaca ttgcttagca ttactgatga aactgaggag      780

aatttcatta gggagcatat gtcctcaaag acagtagagg tgtggatggg tctgaaccag      840

ctcgacgaac acgccggttg gcagtggtca gatggaacgc ctctgaatta tctcaactgg      900

tcccctgagg tcaactttga accgtttgtg gaagatcatt gtggtacttt ttccagtttt      960

atgccaagcg cctggcgaag ccgagactgc gagtctacgt tgccctatat ctgcaagaag     1020

tatttgaatc acatagatca tgaaattgtt gaagctagct tcgtgccggt cttcctgcca     1080

gcgaagccaa ccacgacgcc agcaccgcga ccaccaacac ctgcgcccac catcgcgtcg     1140

cagcccctgt ccctgcgccc agaggcgtgc agaccagcag cggggggcgc agtgcacacg     1200

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1260

gtccttctcc tgtcactggt tatcaccctt tactgcaagc gcggtcgcaa gaaactgctc     1320

tatattttta aacagccatt catgagacct gtccagacca ctcaagagga ggacggatgt     1380

tcctgtagat ttcctgaaga ggaagagggg gggtgcgagc tgagagtgaa gttcagcagg     1440

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1500

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1560

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1620

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1680

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1740

caggccctgc cccctcgcta a                                               1761


<210>  28
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR construct CF1

<400>  28

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
145                 150                 155                 160 


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
                165                 170                 175     


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
            180                 185                 190         


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
        195                 200                 205             


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
    210                 215                 220                 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
225                 230                 235                 240 


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
                245                 250                 255     


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
            260                 265                 270         


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
        275                 280                 285             


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
    290                 295                 300                 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
                325                 330                 335     


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Ala 
            340                 345                 350         


Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
        355                 360                 365             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    370                 375                 380                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
385                 390                 395                 400 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                405                 410                 415     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            420                 425                 430         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        435                 440                 445             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    450                 455                 460                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
465                 470                 475                 480 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                485                 490                 495     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            500                 505                 510         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        515                 520                 525             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    530                 535                 540                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
545                 550                 555                 560 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                565                 570                 575     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585     


<210>  29
<211>  2490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF123

<400>  29
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggga ttttcgtgat acagtccgag agtctcaaaa agtgtatcca ggcaggcaaa      120

agtgttctca ctctggaaaa ctgcaaacaa gcgaacaagc acatgttgtg gaagtgggtt      180

agtaaccatg gactgttcaa catcggaggt agtggatgcc ttggtctcaa tttctctgct      240

ccggaacagc ctttgtcact gtacgaatgc gactccactc tcgttagtct tagatggcga      300

tgcaatcgca aaatgattac gggaccactt caatattcag ttcaagtggc acatgataac      360

accgtagtgg cctcacggaa atacatccat aaatggattt cttatggtag cgggggcggc      420

gatatatgtg aatacctcca taaggatctc cacaccatta agggtaatac tcacggtatg      480

ccgtgtatgt ttccttttca gtacaatcat cagtggcatc atgaatgcac gagggaagga      540

cgcgaggacg atttgctctg gtgcgcaacc acctcacgct acgagagaga cgaaaaatgg      600

ggcttttgcc cggaccccac tagtgctgag gtaggatgtg atacgatttg ggaaaaggat      660

ttgaattctc atatttgcta ccagtttaat cttctttcat ccctgtcctg gtctgaggct      720

cattctagtt gccagatgca aggtgggact ttgctttcaa ttactgacga gactgaggaa      780

aattttatcc gagagcatat gtcttctaaa accgtagagg tatggatggg cctgaaccaa      840

ttggacgaac acgcgggctg gcagtggagc gacgggacac ctctcaacta ccttaattgg      900

agccctgagg taaactttga accgtttgtc gaggatcact gcggaacttt cagcagcttc      960

atgcctagtg catggcggtc ccgagactgt gagagcaccc ttccatacat atgtaaaaaa     1020

tacctcaatc acatagacca cgagatcgta gagaaggatg catggaaata ttatgctacg     1080

cactgtgagc cgggatggaa tccttataac cgcaactgtt acaagctgca aaaagaagag     1140

aagacatggc atgaggcgct gcgctcatgt caagcggaca attctgcact tatagatata     1200

actagtttgg cggaggtaga atttttggtt acgcttctcg gcgatgagaa tgcgtccgag     1260

acgtggatag ggttgtcaag caataaaatt cctgtaagtt ttgaatggtc aaatgactct     1320

tctgtcatct tcaccaattg gcacacactc gaaccccata tcttcccaaa ccgaagccag     1380

ttgtgtgtca gcgctgagca atcagaagga cattggaaag ttaaaaactg tgaagaaaga     1440

ctgttctaca tctgtaagaa ggcaggacat gtgctttcag atgcggaaag cggctgtcaa     1500

gaaggttggg agcgccatgg aggtttctgt tataaaatcg acacagtttt gcgatctttc     1560

gatcaggctt caagcgggta ctattgtcct cctgcactgg ttacaatcac gaaccggttt     1620

gaacaggctt ttataacttc tttgatttcc agcgtggtta aaatgaagga ctcttatttc     1680

tggatagccc tgcaagacca aaatgatacc ggtgagtaca catggaaacc ggtaggtcaa     1740

aagccagagc cagtccagta cactcattgg aatacccacc agcctaggta ctccggcggg     1800

tgtgtggcga tgcggggtcg ccaccctctc ggacgctggg aggtgaagca ttgccgccac     1860

ttcaaggcga tgagcttgtg taaacagccc gtcgaaaatc aggaaaaggc agctagcggt     1920

ggcggaggtt ctggaggtgg aggttcctcc ggaatctaca tctgggcgcc cttggccggg     1980

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaagcg cggtcgcaag     2040

aaactgctct atatttttaa acagccattc atgagacctg tccagaccac tcaagaggag     2100

gacggatgtt cctgtagatt tcctgaagag gaagaggggg ggtgcgagct gagagtgaag     2160

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     2220

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     2280

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     2340

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     2400

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     2460

cttcacatgc aggccctgcc ccctcgctaa                                      2490


<210>  30
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF123

<400>  30

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
145                 150                 155                 160 


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
                165                 170                 175     


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
            180                 185                 190         


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
        195                 200                 205             


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
    210                 215                 220                 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
225                 230                 235                 240 


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
                245                 250                 255     


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
            260                 265                 270         


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
        275                 280                 285             


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
    290                 295                 300                 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
                325                 330                 335     


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
            340                 345                 350         


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
        355                 360                 365             


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
    370                 375                 380                 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
385                 390                 395                 400 


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
                405                 410                 415     


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
            420                 425                 430         


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
        435                 440                 445             


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
    450                 455                 460                 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
465                 470                 475                 480 


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
                485                 490                 495     


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
            500                 505                 510         


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
        515                 520                 525             


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
    530                 535                 540                 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
545                 550                 555                 560 


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
                565                 570                 575     


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
            580                 585                 590         


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
        595                 600                 605             


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
    610                 615                 620                 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Ala Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala 
                645                 650                 655     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            660                 665                 670         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        675                 680                 685             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    690                 695                 700                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
705                 710                 715                 720 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                725                 730                 735     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            740                 745                 750         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        755                 760                 765             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    770                 775                 780                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
785                 790                 795                 800 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                805                 810                 815     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            820                 825                 


<210>  31
<211>  2910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF1237

<400>  31
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggga ttttcgtgat acagtccgag agtctcaaaa agtgtatcca ggcaggcaaa      120

agtgttctca ctctggaaaa ctgcaaacaa gcgaacaagc acatgttgtg gaagtgggtt      180

agtaaccatg gactgttcaa catcggaggt agtggatgcc ttggtctcaa tttctctgct      240

ccggaacagc ctttgtcact gtacgaatgc gactccactc tcgttagtct tagatggcga      300

tgcaatcgca aaatgattac gggaccactt caatattcag ttcaagtggc acatgataac      360

accgtagtgg cctcacggaa atacatccat aaatggattt cttatggtag cgggggcggc      420

gatatatgtg aatacctcca taaggatctc cacaccatta agggtaatac tcacggtatg      480

ccgtgtatgt ttccttttca gtacaatcat cagtggcatc atgaatgcac gagggaagga      540

cgcgaggacg atttgctctg gtgcgcaacc acctcacgct acgagagaga cgaaaaatgg      600

ggcttttgcc cggaccccac tagtgctgag gtaggatgtg atacgatttg ggaaaaggat      660

ttgaattctc atatttgcta ccagtttaat cttctttcat ccctgtcctg gtctgaggct      720

cattctagtt gccagatgca aggtgggact ttgctttcaa ttactgacga gactgaggaa      780

aattttatcc gagagcatat gtcttctaaa accgtagagg tatggatggg cctgaaccaa      840

ttggacgaac acgcgggctg gcagtggagc gacgggacac ctctcaacta ccttaattgg      900

agccctgagg taaactttga accgtttgtc gaggatcact gcggaacttt cagcagcttc      960

atgcctagtg catggcggtc ccgagactgt gagagcaccc ttccatacat atgtaaaaaa     1020

tacctcaatc acatagacca cgagatcgta gagaaggatg catggaaata ttatgctacg     1080

cactgtgagc cgggatggaa tccttataac cgcaactgtt acaagctgca aaaagaagag     1140

aagacatggc atgaggcgct gcgctcatgt caagcggaca attctgcact tatagatata     1200

actagtttgg cggaggtaga atttttggtt acgcttctcg gcgatgagaa tgcgtccgag     1260

acgtggatag ggttgtcaag caataaaatt cctgtaagtt ttgaatggtc aaatgactct     1320

tctgtcatct tcaccaattg gcacacactc gaaccccata tcttcccaaa ccgaagccag     1380

ttgtgtgtca gcgctgagca atcagaagga cattggaaag ttaaaaactg tgaagaaaga     1440

ctgttctaca tctgtaagaa ggcaggacat gtgctttcag atgcggaaag cggctgtcaa     1500

gaaggttggg agcgccatgg aggtttctgt tataaaatcg acacagtttt gcgatctttc     1560

gatcaggctt caagcgggta ctattgtcct cctgcactgg ttacaatcac gaaccggttt     1620

gaacaggctt ttataacttc tttgatttcc agcgtggtta aaatgaagga ctcttatttc     1680

tggatagccc tgcaagacca aaatgatacc ggtgagtaca catggaaacc ggtaggtcaa     1740

aagccagagc cagtccagta cactcattgg aatacccacc agcctaggta ctccggcggg     1800

tgtgtggcga tgcggggtcg ccaccctctc ggacgctggg aggtgaagca ttgccgccac     1860

ttcaaggcga tgagcttgtg taaacagccc gtcgaaaatc aggaaaaggc agttaacaca     1920

tctgatatgt accctatgcc taacacactc gaatatggga ataggacgta caagattata     1980

aacgcgaaca tgacgtggta tgctgcaatc aagacgtgcc tcatgcacaa agctcagctt     2040

gtgtctatta ctgaccaata ccaccaatca tttttgacag tcgtgttgaa tcgattgggg     2100

tacgcccatt ggatcggtct cttcacgacg gacaatgggc tcaattttga ctggagtgac     2160

ggtactaaat catcctttac tttttggaag gatgaagaaa gttctctgtt gggcgattgc     2220

gtgtttgctg actcaaatgg ccgatggcat tccacagcct gtgaaagttt tctgcaggga     2280

gctatttgcc acgtgcctcc cgaaacgcgg cagtccgaac acccggaatt ggctagcggt     2340

ggcggaggtt ctggaggtgg aggttcctcc ggaatctaca tctgggcgcc cttggccggg     2400

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaagcg cggtcgcaag     2460

aaactgctct atatttttaa acagccattc atgagacctg tccagaccac tcaagaggag     2520

gacggatgtt cctgtagatt tcctgaagag gaagaggggg ggtgcgagct gagagtgaag     2580

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     2640

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     2700

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     2760

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     2820

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     2880

cttcacatgc aggccctgcc ccctcgctaa                                      2910


<210>  32
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF1237

<400>  32

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
145                 150                 155                 160 


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
                165                 170                 175     


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
            180                 185                 190         


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
        195                 200                 205             


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
    210                 215                 220                 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
225                 230                 235                 240 


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
                245                 250                 255     


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
            260                 265                 270         


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
        275                 280                 285             


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
    290                 295                 300                 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
                325                 330                 335     


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
            340                 345                 350         


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
        355                 360                 365             


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
    370                 375                 380                 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
385                 390                 395                 400 


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
                405                 410                 415     


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
            420                 425                 430         


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
        435                 440                 445             


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
    450                 455                 460                 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
465                 470                 475                 480 


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
                485                 490                 495     


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
            500                 505                 510         


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
        515                 520                 525             


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
    530                 535                 540                 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
545                 550                 555                 560 


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
                565                 570                 575     


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
            580                 585                 590         


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
        595                 600                 605             


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
    610                 615                 620                 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Val Asn Thr 
625                 630                 635                 640 


Ser Asp Met Tyr Pro Met Pro Asn Thr Leu Glu Tyr Gly Asn Arg Thr 
                645                 650                 655     


Tyr Lys Ile Ile Asn Ala Asn Met Thr Trp Tyr Ala Ala Ile Lys Thr 
            660                 665                 670         


Cys Leu Met His Lys Ala Gln Leu Val Ser Ile Thr Asp Gln Tyr His 
        675                 680                 685             


Gln Ser Phe Leu Thr Val Val Leu Asn Arg Leu Gly Tyr Ala His Trp 
    690                 695                 700                 


Ile Gly Leu Phe Thr Thr Asp Asn Gly Leu Asn Phe Asp Trp Ser Asp 
705                 710                 715                 720 


Gly Thr Lys Ser Ser Phe Thr Phe Trp Lys Asp Glu Glu Ser Ser Leu 
                725                 730                 735     


Leu Gly Asp Cys Val Phe Ala Asp Ser Asn Gly Arg Trp His Ser Thr 
            740                 745                 750         


Ala Cys Glu Ser Phe Leu Gln Gly Ala Ile Cys His Val Pro Pro Glu 
        755                 760                 765             


Thr Arg Gln Ser Glu His Pro Glu Leu Ala Ser Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
785                 790                 795                 800 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                805                 810                 815     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            820                 825                 830         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        835                 840                 845             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    850                 855                 860                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
865                 870                 875                 880 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                885                 890                 895     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            900                 905                 910         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        915                 920                 925             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    930                 935                 940                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
945                 950                 955                 960 


Leu His Met Gln Ala Leu Pro Pro Arg 
                965                 


<210>  33
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF17

<400>  33
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggca tcttcgtaat ccagtcagaa agtttgaaaa aatgtatcca agctggcaaa      120

tcagtactta cccttgagaa ctgcaagcaa gccaataaac atatgctgtg gaaatgggtc      180

tcaaaccacg gcctcttcaa tattggtggg tcaggttgct tggggttgaa tttctccgcc      240

ccagagcaac cactcagcct ttacgagtgt gattccacac ttgtctcttt gcgatggcgc      300

tgcaatagga aaatgatcac aggccccctt cagtactctg tgcaagttgc tcatgataac      360

acagtcgtgg cgagtcggaa atatattcac aaatggattt cttatgggag tggtggagga      420

gatatatgcg agtatttgca taaggacttg cacaccatca agggaaacac tcacggtatg      480

ccatgtatgt ttccgttcca atataatcat caatggcacc acgaatgtac ccgagaggga      540

cgcgaggacg atcttctttg gtgcgccaca acctctcgat atgaacgaga tgagaagtgg      600

gggttttgtc ctgacccaac cagtgcagaa gtagggtgcg ataccatctg ggagaaagac      660

ttgaactcac acatatgcta tcagtttaat ttgttgtctt ctttgtcatg gagcgaagct      720

cattcatcat gccagatgca gggcgggaca ctgctttcta tcaccgacga gactgaggaa      780

aattttatcc gcgagcacat gtcaagcaag acagttgagg tttggatggg gctcaatcaa      840

ctggacgaac acgcagggtg gcagtggtcc gatggcactc cgctcaacta ccttaactgg      900

agcccagagg tgaactttga gccgtttgtc gaagatcact gtggtacttt tagctccttc      960

atgccgtccg catggagaag tcgcgactgc gagtcaaccc tcccttacat ctgtaagaaa     1020

tacctcaacc acatagatca cgaaatcgta gaggtcaata cgtccgacat gtacccaatg     1080

ccaaatacgt tggaatatgg gaataggaca tacaagataa ttaacgcaaa tatgacgtgg     1140

tatgccgcaa tcaaaacgtg cctcatgcac aaggcacagc tcgtgtcaat tacggaccag     1200

taccaccaat catttctcac agtcgttctt aatcgattgg gttatgcaca ctggataggc     1260

ttgttcacga cggacaatgg tttgaacttt gactggtccg atggaactaa aagttctttc     1320

actttttgga aggatgagga gtcctccttg ctcggggact gcgtcttcgc agattcaaac     1380

gggcgctggc actcaacggc atgtgagtcc ttcctgcagg gagctatatg ccatgtgcca     1440

ccagaaacac gccagtctga gcaccctgag ttggctagcg gtggcggagg ttctggaggt     1500

ggaggttcct ccggaatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc     1560

ctgtcactgg ttatcaccct ttactgcaag cgcggtcgca agaaactgct ctatattttt     1620

aaacagccat tcatgagacc tgtccagacc actcaagagg aggacggatg ttcctgtaga     1680

tttcctgaag aggaagaggg ggggtgcgag ctgagagtga agttcagcag gagcgcagac     1740

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1800

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1860

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1920

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1980

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     2040

ccccctcgct aa                                                         2052


<210>  34
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct CF17

<400>  34

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
145                 150                 155                 160 


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
                165                 170                 175     


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
            180                 185                 190         


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
        195                 200                 205             


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
    210                 215                 220                 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
225                 230                 235                 240 


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
                245                 250                 255     


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
            260                 265                 270         


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
        275                 280                 285             


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
    290                 295                 300                 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
                325                 330                 335     


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Val 
            340                 345                 350         


Asn Thr Ser Asp Met Tyr Pro Met Pro Asn Thr Leu Glu Tyr Gly Asn 
        355                 360                 365             


Arg Thr Tyr Lys Ile Ile Asn Ala Asn Met Thr Trp Tyr Ala Ala Ile 
    370                 375                 380                 


Lys Thr Cys Leu Met His Lys Ala Gln Leu Val Ser Ile Thr Asp Gln 
385                 390                 395                 400 


Tyr His Gln Ser Phe Leu Thr Val Val Leu Asn Arg Leu Gly Tyr Ala 
                405                 410                 415     


His Trp Ile Gly Leu Phe Thr Thr Asp Asn Gly Leu Asn Phe Asp Trp 
            420                 425                 430         


Ser Asp Gly Thr Lys Ser Ser Phe Thr Phe Trp Lys Asp Glu Glu Ser 
        435                 440                 445             


Ser Leu Leu Gly Asp Cys Val Phe Ala Asp Ser Asn Gly Arg Trp His 
    450                 455                 460                 


Ser Thr Ala Cys Glu Ser Phe Leu Gln Gly Ala Ile Cys His Val Pro 
465                 470                 475                 480 


Pro Glu Thr Arg Gln Ser Glu His Pro Glu Leu Ala Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro Leu 
            500                 505                 510         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        515                 520                 525             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    530                 535                 540                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
545                 550                 555                 560 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                565                 570                 575     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            580                 585                 590         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        595                 600                 605             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    610                 615                 620                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
625                 630                 635                 640 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                645                 650                 655     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            660                 665                 670         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680             


<210>  35
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct C17

<400>  35
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccaaaggaa tcttcgtaat tcaatctgag agtctgaaaa aatgtattca ggccggtaag      120

agcgtactca cgcttgaaaa ttgcaaacag gccaacaaac acatgctttg gaaatgggtt      180

tcaaatcacg ggttgtttaa cataggggga tcaggatgtc tgggccttaa cttttccgca      240

cctgaacaac ctcttagtct gtatgagtgt gactcaacgc tggtctcctt gcgctggaga      300

tgcaatcgga agatgataac cgggcccctc cagtattccg ttcaggtcgc ccacgataat      360

actgttgttg catcccgaaa atatattcat aagtggatct cctacgggag tggagggggc      420

gatatttgtg aatacctcca caaggatctg cacactatca cttctgcgga agtaggctgt      480

gacacaatct gggagaaaga tctgaattca cacatttgct atcagttcaa tcttctgagt      540

tctttgagct ggtccgaagc acattcatcc tgtcagatgc aaggtggaac actcttgtca      600

ataacagatg aaacggaaga gaactttatt agagaacata tgtcctcaaa gactgtggag      660

gtgtggatgg gacttaacca gctcgatgaa catgcaggat ggcagtggag tgacggaacg      720

ccactgaact acctgaattg gagcccagag gtgaatttcg agcctttcgt agaggaccat      780

tgcggtactt tttcatcttt tatgcccagc gcatggagat cccgagattg tgaaagcacg      840

ctgccctata tttgtaaaaa gtacctgaac cacatagatc atgagatagt tgaggtaaat      900

acaagtgata tgtaccccat gccgaacaca ctcgagtacg gaaatagaac ctacaagata      960

atcaacgcta acatgacctg gtacgcggcc attaagacct gcctcatgca caaggctcaa     1020

ctcgtcagta ttactgacca atatcaccag tcatttctca ccgtcgtgtt gaatcgcctc     1080

ggttacgccc actggatcgg tttgtttaca acggacaatg gactcaattt cgattggtca     1140

gacggaacca aatctagttt taccttctgg aaagacgagg aatcaagcct gcttggggac     1200

tgcgtatttg cggactctaa tggccgatgg catagtacag cgtgtgagag ctttttgcag     1260

ggggcgattt gtcatgttcc gccggaaacc cgccaaagcg agcatccaga attggctagc     1320

ggtggcggag gttctggagg tggaggttcc tccggaatct acatctgggc gcccttggcc     1380

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa gcgcggtcgc     1440

aagaaactgc tctatatttt taaacagcca ttcatgagac ctgtccagac cactcaagag     1500

gaggacggat gttcctgtag atttcctgaa gaggaagagg gggggtgcga gctgagagtg     1560

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1620

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1680

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1740

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1800

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1860

gcccttcaca tgcaggccct gccccctcgc taa                                  1893


<210>  36
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct C17

<400>  36

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
            20                  25                  30          


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
        35                  40                  45              


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
    50                  55                  60                  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
65                  70                  75                  80  


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
                85                  90                  95      


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
            100                 105                 110         


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
        115                 120                 125             


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
    130                 135                 140                 


Tyr Leu His Lys Asp Leu His Thr Ile Thr Ser Ala Glu Val Gly Cys 
145                 150                 155                 160 


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
                165                 170                 175     


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
            180                 185                 190         


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
        195                 200                 205             


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
    210                 215                 220                 


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
225                 230                 235                 240 


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
                245                 250                 255     


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
            260                 265                 270         


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
        275                 280                 285             


Leu Asn His Ile Asp His Glu Ile Val Glu Val Asn Thr Ser Asp Met 
    290                 295                 300                 


Tyr Pro Met Pro Asn Thr Leu Glu Tyr Gly Asn Arg Thr Tyr Lys Ile 
305                 310                 315                 320 


Ile Asn Ala Asn Met Thr Trp Tyr Ala Ala Ile Lys Thr Cys Leu Met 
                325                 330                 335     


His Lys Ala Gln Leu Val Ser Ile Thr Asp Gln Tyr His Gln Ser Phe 
            340                 345                 350         


Leu Thr Val Val Leu Asn Arg Leu Gly Tyr Ala His Trp Ile Gly Leu 
        355                 360                 365             


Phe Thr Thr Asp Asn Gly Leu Asn Phe Asp Trp Ser Asp Gly Thr Lys 
    370                 375                 380                 


Ser Ser Phe Thr Phe Trp Lys Asp Glu Glu Ser Ser Leu Leu Gly Asp 
385                 390                 395                 400 


Cys Val Phe Ala Asp Ser Asn Gly Arg Trp His Ser Thr Ala Cys Glu 
                405                 410                 415     


Ser Phe Leu Gln Gly Ala Ile Cys His Val Pro Pro Glu Thr Arg Gln 
            420                 425                 430         


Ser Glu His Pro Glu Leu Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    450                 455                 460                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                485                 490                 495     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            500                 505                 510         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        515                 520                 525             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    530                 535                 540                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
545                 550                 555                 560 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                565                 570                 575     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            580                 585                 590         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        595                 600                 605             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    610                 615                 620                 


Gln Ala Leu Pro Pro Arg 
625                 630 


<210>  37
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4025.C

<400>  37
atgctgctga gccctagcct gctgctgctc ctgcttcttg gagcccctag aggatgtgcc       60

ggatctgaag gtgttgccgc cgctctgaca cccgagagac tgctggaatg gcaggacaag      120

ggcatcttcg tgatccagag cgagagcctg aagaagtgca tccaggccgg caagagcgtg      180

ctgaccctgg aaaattgcaa gcaggccaac aagcacatgc tgtggaaatg ggtgtccaac      240

cacggcctgt tcaacatcgg cggctctgga tgtctgggcc tgaatttctc tgcccctgag      300

cagcctctga gcctgtacga gtgtgatagc accctggtgt ccctgagatg gcggtgcaac      360

cggaagatga tcacaggccc tctgcagtac tctgtgcagg tcgcccacga caataccgtg      420

gtggccagca gaaagtacat ccacaagtgg atcagctacg gcagcggcgg aggcgacatc      480

tgtgaatacc tgcacaagga tctgtccgga accacgacgc cagcgccgcg accaccaaca      540

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      600

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      660

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa      720

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact      780

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa      840

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag      900

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      960

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1020

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1080

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1140

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1182


<210>  38
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4025.C

<400>  38

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Gly Ser Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu Ser Gly Thr Thr Thr Pro Ala Pro 
                165                 170                 175     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            180                 185                 190         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        195                 200                 205             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    210                 215                 220                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
225                 230                 235                 240 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                245                 250                 255     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            260                 265                 270         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        275                 280                 285             


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    290                 295                 300                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
305                 310                 315                 320 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                325                 330                 335     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            340                 345                 350         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        355                 360                 365             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    370                 375                 380                 


Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390             


<210>  39
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4026.CF1

<400>  39
atgctgctga gccctagcct gctgctgctc ctgcttcttg gagcccctag aggatgtgcc       60

ggatctgaag gtgttgccgc cgctctgaca cccgagagac tgctggaatg gcaggacaag      120

ggcatcttcg tgatccagag cgagagcctg aagaagtgca tccaggccgg caagagcgtg      180

ctgaccctgg aaaattgcaa gcaggccaac aagcacatgc tgtggaaatg ggtgtccaac      240

cacggcctgt tcaacatcgg cggctctgga tgtctgggcc tgaatttctc tgcccctgag      300

cagcctctga gcctgtacga gtgtgatagc accctggtgt ccctgagatg gcggtgcaac      360

cggaagatga tcacaggccc tctgcagtac tctgtgcagg tcgcccacga caataccgtg      420

gtggccagca gaaagtacat ccacaagtgg atcagctacg gcagcggcgg aggcgacatc      480

tgtgaatacc tgcacaagga tctgcacacc atcaagggca acacccacgg aatgccctgc      540

atgttcccgt ttcagtacaa ccaccagtgg caccacgagt gcaccagaga aggcagagag      600

gacgacctgc tttggtgcgc cacaaccagc agatacgagc gggatgagaa gtggggcttc      660

tgccctgatc ctacctctgc cgaagtgggc tgcgatacca tctgggagaa agacctgaac      720

agccacatct gctaccagtt caacctgctg tccagcctgt cttggagcga ggcccacagc      780

agctgtcaaa tgcaaggcgg cacactgctg agcatcaccg acgagacaga ggaaaacttc      840

atccgcgagc acatgagcag caagaccgtg gaagtgtgga tgggactgaa ccagctggat      900

gagcatgccg gatggcagtg gagtgatggc acccctctga actacctgaa ctggtcccct      960

gaagtgaact tcgagccctt cgtggaagat cactgcggca ccttcagcag cttcatgccc     1020

agcgcttgga gaagcagaga ctgcgagagc accctgcctt acatctgcaa gaagtacctg     1080

aaccacatcg accacgagat cgtggaaaag gacgcctgga agtactacgc cacacactgc     1140

gagtccggaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1200

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg     1260

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1320

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1380

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1440

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1500

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1560

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1620

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1680

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1740

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1800

caggccctgc cccctcgcta a                                               1821


<210>  40
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLA2R-CAAR Construct 4026.CF1

<400>  40

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Gly Ser Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Ser Gly Thr 
    370                 375                 380                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
385                 390                 395                 400 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                405                 410                 415     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            420                 425                 430         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        435                 440                 445             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    450                 455                 460                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
465                 470                 475                 480 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                485                 490                 495     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            500                 505                 510         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        515                 520                 525             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    530                 535                 540                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
545                 550                 555                 560 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                565                 570                 575     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            580                 585                 590         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605     


<210>  41
<211>  4441
<212>  DNA
<213>  Homo sapiens

<400>  41
ccggagagcc cagtggttag cgatgctgct gtcgccgtcg ctgctgctgc tgctgctgct       60

gggggcgccg cggggctgcg ccgagggtgt ggcggcggcg cttacccccg agcggctcct      120

ggagtggcag gataaaggaa tatttgttat ccaaagtgag agtctcaaga aatgcattca      180

agcaggtaaa tcggttctga ccctggagaa ctgcaagcaa gcaaacaagc acatgctgtg      240

gaaatgggtt tcaaaccatg gcctctttaa cataggaggc agcggttgcc tgggcctgaa      300

tttctccgcc ccagagcagc cattaagctt atatgaatgt gactccaccc tcgtttcctt      360

acggtggcgc tgtaacagga agatgatcac aggcccgctg cagtactctg tccaggtggc      420

gcatgacaac acagtggtgg cctcacggaa gtatattcat aagtggattt cttatgggtc      480

aggtggtgga gacatttgtg aatatctaca caaagatttg catacaatca aagggaacac      540

ccacgggatg ccgtgtatgt ttcccttcca gtataaccat cagtggcatc atgaatgtac      600

ccgtgaaggt cgggaagatg acttactgtg gtgtgccacg acaagccgtt atgaaagaga      660

tgaaaagtgg ggattttgcc ctgatcccac ctctgcagaa gtaggttgtg atactatttg      720

ggagaaggac ctcaattcac acatttgcta ccagttcaac ctgctttcat ctctctcttg      780

gagtgaggca cattcttcat gccagatgca aggaggtacg ctgttaagta ttacagatga      840

aactgaagaa aatttcataa gggagcacat gagcagtaaa acagtggagg tgtggatggg      900

cctcaatcag ctggatgaac acgctggctg gcagtggtct gatggaacgc cgctcaacta      960

tctgaattgg agcccagagg taaattttga gccatttgtt gaagatcact gtggaacatt     1020

tagttcattt atgccaagtg cctggaggag tcgggattgt gagtccacct tgccatatat     1080

atgtaaaaaa tatctaaacc acattgatca tgaaatagtt gaaaaagatg cgtggaaata     1140

ttatgctacc cactgtgagc ctggctggaa tccctacaat cgtaattgct acaaacttca     1200

gaaagaagaa aagacctggc atgaggctct gcgttcttgt caggctgata acagtgcatt     1260

aatagacata acctcattag cagaggtgga gtttcttgta accctccttg gagatgaaaa     1320

tgcatcagaa acatggattg gtttgagcag caataaaatt ccagtttcct ttgaatggtc     1380

taatgactct tcagtcatct ttactaattg gcacacactt gagccccaca tttttccaaa     1440

tagaagccag ctgtgtgtct cagcagagca gtctgaggga cactggaaag tcaaaaattg     1500

tgaagaaaga cttttttaca tttgtaaaaa agcaggccat gtcctctctg atgctgaatc     1560

aggatgtcaa gagggatggg agagacatgg tggattctgt tacaaaattg acacagtcct     1620

tcgaagcttt gaccaagctt ccagcggtta ttactgtcct cctgcacttg taaccattac     1680

aaacaggttt gaacaggctt ttattaccag tttgatcagt agtgtggtaa aaatgaagga     1740

cagttatttt tggatagctc ttcaggacca aaatgatacg ggagaataca cttggaagcc     1800

agtagggcag aaacccgagc cggtgcagta cacacactgg aacacacacc agccgcgcta     1860

cagtggtggc tgtgttgcca tgcgaggaag gcatccactt ggtcgctggg aagtgaagca     1920

ctgtcggcac tttaaggcaa tgtccttgtg caagcagcca gttgaaaatc aggaaaaagc     1980

agagtatgaa gagagatggc cctttcaccc ctgctatttg gactgggagt cagagcctgg     2040

tctggccagt tgcttcaagg tatttcatag tgaaaaagtt ctgatgaaaa gaacatggag     2100

agaagctgaa gcattttgcg aagaatttgg agctcatctt gcaagctttg cccatattga     2160

ggaagagaat tttgtgaatg agctcttaca ttcaaaattt aattggacag aagaaaggca     2220

gttctggatt ggatttaata aaagaaaccc actgaatgcc ggctcatggg agtggtctga     2280

tagaactcct gttgtctctt cgtttttaga caacacttat tttggagaag atgcaagaaa     2340

ctgtgctgtt tataaggcaa acaaaacatt gctgccctta cactgtggtt ccaaacgtga     2400

atggatatgc aaaatcccaa gagatgtgaa acccaagatt ccgttctggt accagtacga     2460

tgtaccctgg ctcttttatc aggatgcaga ataccttttt catacctttg cctcagaatg     2520

gttgaacttt gagtttgtct gtagctggct gcacagtgat cttctcacaa ttcattctgc     2580

acatgagcaa gaattcatcc acagcaaaat aaaagcgcta tcaaagtatg gtgcaagttg     2640

gtggattgga cttcaagaag aaagagccaa tgatgaattt cgctggagag atggaacacc     2700

agtgatatac cagaactggg acacaggaag agaaagaact gtgaataatc agagccagag     2760

atgtggcttt atttcttcta taacaggact ctggggtagt gaagagtgtt cagtttctat     2820

gcctagtatc tgtaagcgaa aaaaggtttg gctcatagag aaaaagaaag atacaccaaa     2880

acaacatgga acgtgtccca aaggatggct atattttaac tataagtgcc ttctgctgaa     2940

tatccccaaa gacccaagca gttggaagaa ctggacgcat gctcaacatt tctgtgctga     3000

agaagggggg accctggtcg ccattgaaag tgaggtggag caagctttca ttactatgaa     3060

tctttttggc cagaccacca gtgtgtggat aggtttacaa aatgatgatt atgaaacatg     3120

gctaaatgga aagcctgtgg tatattctaa ctggtctcca tttgatataa taaatattcc     3180

aagtcacaat accactgaag ttcagaaaca cattcctctc tgtgccttac tctcaagtaa     3240

tcctaatttt catttcactg gaaaatggta ttttgaagac tgtggaaagg aaggctatgg     3300

gtttgtttgt gaaaaaatgc aagatacttc tggacacggt gtaaatacat ctgatatgta     3360

tccaatgccc aataccttag aatatggaaa cagaacttac aaaataatta atgcaaatat     3420

gacttggtat gcagcaataa aaacctgcct gatgcacaaa gcacaactgg tcagcatcac     3480

agaccagtat caccagtcct tcctcactgt tgtcctcaac cggctaggat atgcccactg     3540

gattggactg ttcaccacag ataatggtct taattttgac tggtctgatg gcaccaaatc     3600

ttctttcact ttttggaaag atgaggagtc ctccctcctt ggtgactgcg tttttgccga     3660

cagcaacgga cgctggcata gcacagcctg cgagtcattt ctgcaaggtg ccatttgtca     3720

tgtgccacct gaaacaagac aatctgaaca cccagagttg tgctcagaaa catctattcc     3780

ctggataaaa tttaaaagta attgctacag tttttctaca gtcctagaca gtatgagttt     3840

tgaggctgct catgaatttt gcaaaaagga aggttctaat cttttaacaa tcaaggatga     3900

ggctgaaaat gcatttctcc tagaagagct gtttgctttt ggttcttctg tccagatggt     3960

ttggttgaat gctcaatttg atgatgaaac cataaagtgg tttgatggaa ctcccacaga     4020

ccagtcaaac tggggcattc ggaagccaga cacagactac ttcaagcccc atcattgtgt     4080

tgccttgagg atccctgaag gattatggca gctatccccg tgtcaagaaa aaaaaggctt     4140

tatatgtaaa atggaggcag atattcacac tgcagaggcg ctgccagaaa aaggaccaag     4200

tcacagcatc attcctcttg cggttgtact gacactgata gtcattgtgg ccatttgcac     4260

actttccttc tgcatataca agcataacgg tggcttcttc aggagacttg cagggtttcg     4320

gaatccttac tatcctgcaa ccaactttag tacagtatat ttagaagaaa atattctcat     4380

ttctgatctt gagaagagtg accaataata atgaggtcag agaatgccac agacaccagg     4440

g                                                                     4441


<210>  42
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  42
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  43
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  43

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  44
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  44

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  45
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  45

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  46
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG Signal peptide

<400>  46
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgc          57


<210>  47
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR

<400>  47
aaaggaatat ttgtcattca gtcagagtct ttgaaaaagt gcatacaggc tggaaaaagc       60

gtgcttaccc tggagaactg caagcaagct aataagcata tgctttggaa atgggttagc      120

aaccacggac tctttaatat cggaggctcc ggctgtctgg gcctgaactt cagtgcaccg      180

gagcaaccgc tttctctgta cgaatgtgat agcacacttg ttagtcttcg gtggcggtgt      240

aaccgaaaaa tgattacagg ccctctgcaa tatagtgttc aagtggccca cgacaataca      300

gttgtggcgt ctagaaaata tattcacaag tggatttcct acgggagcgg cggaggggat      360

atatgtgaat atcttcacaa agacttgcat acaatc                                396


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Signal peptide

<400>  48

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  49
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR

<400>  49

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile 
    130         


<210>  50
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1

<400>  50
aaagggatct ttgttataca aagtgagagc ttgaaaaaat gtatacaggc tggcaaaagt       60

gtactgactc ttgaaaattg caaacaagcc aacaaacaca tgctgtggaa atgggtgtct      120

aatcacggtc tcttcaatat tgggggaagt ggatgcctcg gcctgaattt ctccgctccc      180

gaacagcccc tctcacttta tgagtgtgat tcaactctgg tgtccttgag gtggcgatgt      240

aaccgcaaga tgataaccgg ccccctccag tattccgtcc aagtagcaca cgacaatacc      300

gtggtggcat ctaggaaata cattcataag tggatatctt atggcagtgg tggcggtgac      360

atatgcgagt acctgcacaa ggacctccac acaataaagg ggaacacgca cgggatgccg      420

tgtatgttcc cgttccaata taatcatcaa tggcaccatg agtgtacgag agaggggcga      480

gaagacgacc tcctgtggtg tgcgaccacc tcaagatatg aacgggatga gaagtggggc      540

ttttgccccg acccaacctc cgccgaggtt ggttgcgaca ctatttggga aaaagatttg      600

aacagtcata tatgctatca atttaatttg ttgagttcac tctcctggag cgaagcgcac      660

agctcttgtc agatgcaagg tggtacattg cttagcatta ctgatgaaac tgaggagaat      720

ttcattaggg agcatatgtc ctcaaagaca gtagaggtgt ggatgggtct gaaccagctc      780

gacgaacacg ccggttggca gtggtcagat ggaacgcctc tgaattatct caactggtcc      840

cctgaggtca actttgaacc gtttgtggaa gatcattgtg gtactttttc cagttttatg      900

ccaagcgcct ggcgaagccg agactgcgag tctacgttgc cctatatctg caagaagtat      960

ttgaatcaca tagatcatga aattgttgaa                                       990


<210>  51
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1

<400>  51

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu 
                325                 330 


<210>  52
<211>  1848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1-3

<400>  52
aaagggattt tcgtgataca gtccgagagt ctcaaaaagt gtatccaggc aggcaaaagt       60

gttctcactc tggaaaactg caaacaagcg aacaagcaca tgttgtggaa gtgggttagt      120

aaccatggac tgttcaacat cggaggtagt ggatgccttg gtctcaattt ctctgctccg      180

gaacagcctt tgtcactgta cgaatgcgac tccactctcg ttagtcttag atggcgatgc      240

aatcgcaaaa tgattacggg accacttcaa tattcagttc aagtggcaca tgataacacc      300

gtagtggcct cacggaaata catccataaa tggatttctt atggtagcgg gggcggcgat      360

atatgtgaat acctccataa ggatctccac accattaagg gtaatactca cggtatgccg      420

tgtatgtttc cttttcagta caatcatcag tggcatcatg aatgcacgag ggaaggacgc      480

gaggacgatt tgctctggtg cgcaaccacc tcacgctacg agagagacga aaaatggggc      540

ttttgcccgg accccactag tgctgaggta ggatgtgata cgatttggga aaaggatttg      600

aattctcata tttgctacca gtttaatctt ctttcatccc tgtcctggtc tgaggctcat      660

tctagttgcc agatgcaagg tgggactttg ctttcaatta ctgacgagac tgaggaaaat      720

tttatccgag agcatatgtc ttctaaaacc gtagaggtat ggatgggcct gaaccaattg      780

gacgaacacg cgggctggca gtggagcgac gggacacctc tcaactacct taattggagc      840

cctgaggtaa actttgaacc gtttgtcgag gatcactgcg gaactttcag cagcttcatg      900

cctagtgcat ggcggtcccg agactgtgag agcacccttc catacatatg taaaaaatac      960

ctcaatcaca tagaccacga gatcgtagag aaggatgcat ggaaatatta tgctacgcac     1020

tgtgagccgg gatggaatcc ttataaccgc aactgttaca agctgcaaaa agaagagaag     1080

acatggcatg aggcgctgcg ctcatgtcaa gcggacaatt ctgcacttat agatataact     1140

agtttggcgg aggtagaatt tttggttacg cttctcggcg atgagaatgc gtccgagacg     1200

tggatagggt tgtcaagcaa taaaattcct gtaagttttg aatggtcaaa tgactcttct     1260

gtcatcttca ccaattggca cacactcgaa ccccatatct tcccaaaccg aagccagttg     1320

tgtgtcagcg ctgagcaatc agaaggacat tggaaagtta aaaactgtga agaaagactg     1380

ttctacatct gtaagaaggc aggacatgtg ctttcagatg cggaaagcgg ctgtcaagaa     1440

ggttgggagc gccatggagg tttctgttat aaaatcgaca cagttttgcg atctttcgat     1500

caggcttcaa gcgggtacta ttgtcctcct gcactggtta caatcacgaa ccggtttgaa     1560

caggctttta taacttcttt gatttccagc gtggttaaaa tgaaggactc ttatttctgg     1620

atagccctgc aagaccaaaa tgataccggt gagtacacat ggaaaccggt aggtcaaaag     1680

ccagagccag tccagtacac tcattggaat acccaccagc ctaggtactc cggcgggtgt     1740

gtggcgatgc ggggtcgcca ccctctcgga cgctgggagg tgaagcattg ccgccacttc     1800

aaggcgatga gcttgtgtaa acagcccgtc gaaaatcagg aaaaggca                  1848


<210>  53
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1-3

<400>  53

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Lys Asp Ala Trp Lys Tyr 
                325                 330                 335     


Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro Tyr Asn Arg Asn Cys 
            340                 345                 350         


Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His Glu Ala Leu Arg Ser 
        355                 360                 365             


Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile Thr Ser Leu Ala Glu 
    370                 375                 380                 


Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu Asn Ala Ser Glu Thr 
385                 390                 395                 400 


Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val Ser Phe Glu Trp Ser 
                405                 410                 415     


Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu Glu Pro His 
            420                 425                 430         


Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu Gln Ser Glu 
        435                 440                 445             


Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg Leu Phe Tyr Ile Cys 
    450                 455                 460                 


Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu Ser Gly Cys Gln Glu 
465                 470                 475                 480 


Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp Thr Val Leu 
                485                 490                 495     


Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr Cys Pro Pro Ala Leu 
            500                 505                 510         


Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile 
        515                 520                 525             


Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe Trp Ile Ala Leu Gln 
    530                 535                 540                 


Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Pro Val Gly Gln Lys 
545                 550                 555                 560 


Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr His Gln Pro Arg Tyr 
                565                 570                 575     


Ser Gly Gly Cys Val Ala Met Arg Gly Arg His Pro Leu Gly Arg Trp 
            580                 585                 590         


Glu Val Lys His Cys Arg His Phe Lys Ala Met Ser Leu Cys Lys Gln 
        595                 600                 605             


Pro Val Glu Asn Gln Glu Lys Ala 
    610                 615     


<210>  54
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1-3 7

<400>  54
aaagggattt tcgtgataca gtccgagagt ctcaaaaagt gtatccaggc aggcaaaagt       60

gttctcactc tggaaaactg caaacaagcg aacaagcaca tgttgtggaa gtgggttagt      120

aaccatggac tgttcaacat cggaggtagt ggatgccttg gtctcaattt ctctgctccg      180

gaacagcctt tgtcactgta cgaatgcgac tccactctcg ttagtcttag atggcgatgc      240

aatcgcaaaa tgattacggg accacttcaa tattcagttc aagtggcaca tgataacacc      300

gtagtggcct cacggaaata catccataaa tggatttctt atggtagcgg gggcggcgat      360

atatgtgaat acctccataa ggatctccac accattaagg gtaatactca cggtatgccg      420

tgtatgtttc cttttcagta caatcatcag tggcatcatg aatgcacgag ggaaggacgc      480

gaggacgatt tgctctggtg cgcaaccacc tcacgctacg agagagacga aaaatggggc      540

ttttgcccgg accccactag tgctgaggta ggatgtgata cgatttggga aaaggatttg      600

aattctcata tttgctacca gtttaatctt ctttcatccc tgtcctggtc tgaggctcat      660

tctagttgcc agatgcaagg tgggactttg ctttcaatta ctgacgagac tgaggaaaat      720

tttatccgag agcatatgtc ttctaaaacc gtagaggtat ggatgggcct gaaccaattg      780

gacgaacacg cgggctggca gtggagcgac gggacacctc tcaactacct taattggagc      840

cctgaggtaa actttgaacc gtttgtcgag gatcactgcg gaactttcag cagcttcatg      900

cctagtgcat ggcggtcccg agactgtgag agcacccttc catacatatg taaaaaatac      960

ctcaatcaca tagaccacga gatcgtagag aaggatgcat ggaaatatta tgctacgcac     1020

tgtgagccgg gatggaatcc ttataaccgc aactgttaca agctgcaaaa agaagagaag     1080

acatggcatg aggcgctgcg ctcatgtcaa gcggacaatt ctgcacttat agatataact     1140

agtttggcgg aggtagaatt tttggttacg cttctcggcg atgagaatgc gtccgagacg     1200

tggatagggt tgtcaagcaa taaaattcct gtaagttttg aatggtcaaa tgactcttct     1260

gtcatcttca ccaattggca cacactcgaa ccccatatct tcccaaaccg aagccagttg     1320

tgtgtcagcg ctgagcaatc agaaggacat tggaaagtta aaaactgtga agaaagactg     1380

ttctacatct gtaagaaggc aggacatgtg ctttcagatg cggaaagcgg ctgtcaagaa     1440

ggttgggagc gccatggagg tttctgttat aaaatcgaca cagttttgcg atctttcgat     1500

caggcttcaa gcgggtacta ttgtcctcct gcactggtta caatcacgaa ccggtttgaa     1560

caggctttta taacttcttt gatttccagc gtggttaaaa tgaaggactc ttatttctgg     1620

atagccctgc aagaccaaaa tgataccggt gagtacacat ggaaaccggt aggtcaaaag     1680

ccagagccag tccagtacac tcattggaat acccaccagc ctaggtactc cggcgggtgt     1740

gtggcgatgc ggggtcgcca ccctctcgga cgctgggagg tgaagcattg ccgccacttc     1800

aaggcgatga gcttgtgtaa acagcccgtc gaaaatcagg aaaaggcagt taacacatct     1860

gatatgtacc ctatgcctaa cacactcgaa tatgggaata ggacgtacaa gattataaac     1920

gcgaacatga cgtggtatgc tgcaatcaag acgtgcctca tgcacaaagc tcagcttgtg     1980

tctattactg accaatacca ccaatcattt ttgacagtcg tgttgaatcg attggggtac     2040

gcccattgga tcggtctctt cacgacggac aatgggctca attttgactg gagtgacggt     2100

actaaatcat cctttacttt ttggaaggat gaagaaagtt ctctgttggg cgattgcgtg     2160

tttgctgact caaatggccg atggcattcc acagcctgtg aaagttttct gcagggagct     2220

atttgccacg tgcctcccga aacgcggcag tccgaacacc cggaattg                  2268


<210>  55
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1-3 7

<400>  55

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Lys Asp Ala Trp Lys Tyr 
                325                 330                 335     


Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro Tyr Asn Arg Asn Cys 
            340                 345                 350         


Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His Glu Ala Leu Arg Ser 
        355                 360                 365             


Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile Thr Ser Leu Ala Glu 
    370                 375                 380                 


Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu Asn Ala Ser Glu Thr 
385                 390                 395                 400 


Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val Ser Phe Glu Trp Ser 
                405                 410                 415     


Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu Glu Pro His 
            420                 425                 430         


Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu Gln Ser Glu 
        435                 440                 445             


Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg Leu Phe Tyr Ile Cys 
    450                 455                 460                 


Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu Ser Gly Cys Gln Glu 
465                 470                 475                 480 


Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp Thr Val Leu 
                485                 490                 495     


Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr Cys Pro Pro Ala Leu 
            500                 505                 510         


Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile 
        515                 520                 525             


Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe Trp Ile Ala Leu Gln 
    530                 535                 540                 


Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Pro Val Gly Gln Lys 
545                 550                 555                 560 


Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr His Gln Pro Arg Tyr 
                565                 570                 575     


Ser Gly Gly Cys Val Ala Met Arg Gly Arg His Pro Leu Gly Arg Trp 
            580                 585                 590         


Glu Val Lys His Cys Arg His Phe Lys Ala Met Ser Leu Cys Lys Gln 
        595                 600                 605             


Pro Val Glu Asn Gln Glu Lys Ala Val Asn Thr Ser Asp Met Tyr Pro 
    610                 615                 620                 


Met Pro Asn Thr Leu Glu Tyr Gly Asn Arg Thr Tyr Lys Ile Ile Asn 
625                 630                 635                 640 


Ala Asn Met Thr Trp Tyr Ala Ala Ile Lys Thr Cys Leu Met His Lys 
                645                 650                 655     


Ala Gln Leu Val Ser Ile Thr Asp Gln Tyr His Gln Ser Phe Leu Thr 
            660                 665                 670         


Val Val Leu Asn Arg Leu Gly Tyr Ala His Trp Ile Gly Leu Phe Thr 
        675                 680                 685             


Thr Asp Asn Gly Leu Asn Phe Asp Trp Ser Asp Gly Thr Lys Ser Ser 
    690                 695                 700                 


Phe Thr Phe Trp Lys Asp Glu Glu Ser Ser Leu Leu Gly Asp Cys Val 
705                 710                 715                 720 


Phe Ala Asp Ser Asn Gly Arg Trp His Ser Thr Ala Cys Glu Ser Phe 
                725                 730                 735     


Leu Gln Gly Ala Ile Cys His Val Pro Pro Glu Thr Arg Gln Ser Glu 
            740                 745                 750         


His Pro Glu Leu 
        755     


<210>  56
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1 7

<400>  56
aaaggcatct tcgtaatcca gtcagaaagt ttgaaaaaat gtatccaagc tggcaaatca       60

gtacttaccc ttgagaactg caagcaagcc aataaacata tgctgtggaa atgggtctca      120

aaccacggcc tcttcaatat tggtgggtca ggttgcttgg ggttgaattt ctccgcccca      180

gagcaaccac tcagccttta cgagtgtgat tccacacttg tctctttgcg atggcgctgc      240

aataggaaaa tgatcacagg cccccttcag tactctgtgc aagttgctca tgataacaca      300

gtcgtggcga gtcggaaata tattcacaaa tggatttctt atgggagtgg tggaggagat      360

atatgcgagt atttgcataa ggacttgcac accatcaagg gaaacactca cggtatgcca      420

tgtatgtttc cgttccaata taatcatcaa tggcaccacg aatgtacccg agagggacgc      480

gaggacgatc ttctttggtg cgccacaacc tctcgatatg aacgagatga gaagtggggg      540

ttttgtcctg acccaaccag tgcagaagta gggtgcgata ccatctggga gaaagacttg      600

aactcacaca tatgctatca gtttaatttg ttgtcttctt tgtcatggag cgaagctcat      660

tcatcatgcc agatgcaggg cgggacactg ctttctatca ccgacgagac tgaggaaaat      720

tttatccgcg agcacatgtc aagcaagaca gttgaggttt ggatggggct caatcaactg      780

gacgaacacg cagggtggca gtggtccgat ggcactccgc tcaactacct taactggagc      840

ccagaggtga actttgagcc gtttgtcgaa gatcactgtg gtacttttag ctccttcatg      900

ccgtccgcat ggagaagtcg cgactgcgag tcaaccctcc cttacatctg taagaaatac      960

ctcaaccaca tagatcacga aatcgtagag gtcaatacgt ccgacatgta cccaatgcca     1020

aatacgttgg aatatgggaa taggacatac aagataatta acgcaaatat gacgtggtat     1080

gccgcaatca aaacgtgcct catgcacaag gcacagctcg tgtcaattac ggaccagtac     1140

caccaatcat ttctcacagt cgttcttaat cgattgggtt atgcacactg gataggcttg     1200

ttcacgacgg acaatggttt gaactttgac tggtccgatg gaactaaaag ttctttcact     1260

ttttggaagg atgaggagtc ctccttgctc ggggactgcg tcttcgcaga ttcaaacggg     1320

cgctggcact caacggcatg tgagtccttc ctgcagggag ctatatgcca tgtgccacca     1380

gaaacacgcc agtctgagca ccctgagttg                                      1410


<210>  57
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1 7

<400>  57

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Val Asn Thr Ser Asp Met 
                325                 330                 335     


Tyr Pro Met Pro Asn Thr Leu Glu Tyr Gly Asn Arg Thr Tyr Lys Ile 
            340                 345                 350         


Ile Asn Ala Asn Met Thr Trp Tyr Ala Ala Ile Lys Thr Cys Leu Met 
        355                 360                 365             


His Lys Ala Gln Leu Val Ser Ile Thr Asp Gln Tyr His Gln Ser Phe 
    370                 375                 380                 


Leu Thr Val Val Leu Asn Arg Leu Gly Tyr Ala His Trp Ile Gly Leu 
385                 390                 395                 400 


Phe Thr Thr Asp Asn Gly Leu Asn Phe Asp Trp Ser Asp Gly Thr Lys 
                405                 410                 415     


Ser Ser Phe Thr Phe Trp Lys Asp Glu Glu Ser Ser Leu Leu Gly Asp 
            420                 425                 430         


Cys Val Phe Ala Asp Ser Asn Gly Arg Trp His Ser Thr Ala Cys Glu 
        435                 440                 445             


Ser Phe Leu Gln Gly Ala Ile Cys His Val Pro Pro Glu Thr Arg Gln 
    450                 455                 460                 


Ser Glu His Pro Glu Leu 
465                 470 


<210>  58
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-CTLD1 7

<400>  58
aaaggaatct tcgtaattca atctgagagt ctgaaaaaat gtattcaggc cggtaagagc       60

gtactcacgc ttgaaaattg caaacaggcc aacaaacaca tgctttggaa atgggtttca      120

aatcacgggt tgtttaacat agggggatca ggatgtctgg gccttaactt ttccgcacct      180

gaacaacctc ttagtctgta tgagtgtgac tcaacgctgg tctccttgcg ctggagatgc      240

aatcggaaga tgataaccgg gcccctccag tattccgttc aggtcgccca cgataatact      300

gttgttgcat cccgaaaata tattcataag tggatctcct acgggagtgg agggggcgat      360

atttgtgaat acctccacaa ggatctgcac actatcactt ctgcggaagt aggctgtgac      420

acaatctggg agaaagatct gaattcacac atttgctatc agttcaatct tctgagttct      480

ttgagctggt ccgaagcaca ttcatcctgt cagatgcaag gtggaacact cttgtcaata      540

acagatgaaa cggaagagaa ctttattaga gaacatatgt cctcaaagac tgtggaggtg      600

tggatgggac ttaaccagct cgatgaacat gcaggatggc agtggagtga cggaacgcca      660

ctgaactacc tgaattggag cccagaggtg aatttcgagc ctttcgtaga ggaccattgc      720

ggtacttttt catcttttat gcccagcgca tggagatccc gagattgtga aagcacgctg      780

ccctatattt gtaaaaagta cctgaaccac atagatcatg agatagttga ggtaaataca      840

agtgatatgt accccatgcc gaacacactc gagtacggaa atagaaccta caagataatc      900

aacgctaaca tgacctggta cgcggccatt aagacctgcc tcatgcacaa ggctcaactc      960

gtcagtatta ctgaccaata tcaccagtca tttctcaccg tcgtgttgaa tcgcctcggt     1020

tacgcccact ggatcggttt gtttacaacg gacaatggac tcaatttcga ttggtcagac     1080

ggaaccaaat ctagttttac cttctggaaa gacgaggaat caagcctgct tggggactgc     1140

gtatttgcgg actctaatgg ccgatggcat agtacagcgt gtgagagctt tttgcagggg     1200

gcgatttgtc atgttccgcc ggaaacccgc caaagcgagc atccagaatt g              1251


<210>  59
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-CTLD1 7

<400>  59

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu 
    130                 135                 140                 


Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser 
145                 150                 155                 160 


Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr 
                165                 170                 175     


Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His 
            180                 185                 190         


Met Ser Ser Lys Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp 
        195                 200                 205             


Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu 
    210                 215                 220                 


Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys 
225                 230                 235                 240 


Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys 
                245                 250                 255     


Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp 
            260                 265                 270         


His Glu Ile Val Glu Val Asn Thr Ser Asp Met Tyr Pro Met Pro Asn 
        275                 280                 285             


Thr Leu Glu Tyr Gly Asn Arg Thr Tyr Lys Ile Ile Asn Ala Asn Met 
    290                 295                 300                 


Thr Trp Tyr Ala Ala Ile Lys Thr Cys Leu Met His Lys Ala Gln Leu 
305                 310                 315                 320 


Val Ser Ile Thr Asp Gln Tyr His Gln Ser Phe Leu Thr Val Val Leu 
                325                 330                 335     


Asn Arg Leu Gly Tyr Ala His Trp Ile Gly Leu Phe Thr Thr Asp Asn 
            340                 345                 350         


Gly Leu Asn Phe Asp Trp Ser Asp Gly Thr Lys Ser Ser Phe Thr Phe 
        355                 360                 365             


Trp Lys Asp Glu Glu Ser Ser Leu Leu Gly Asp Cys Val Phe Ala Asp 
    370                 375                 380                 


Ser Asn Gly Arg Trp His Ser Thr Ala Cys Glu Ser Phe Leu Gln Gly 
385                 390                 395                 400 


Ala Ile Cys His Val Pro Pro Glu Thr Arg Gln Ser Glu His Pro Glu 
                405                 410                 415     


Leu 
    


<210>  60
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR

<400>  60
aagggcatct tcgtgatcca gagcgagagc ctgaagaagt gcatccaggc cggcaagagc       60

gtgctgaccc tggaaaattg caagcaggcc aacaagcaca tgctgtggaa atgggtgtcc      120

aaccacggcc tgttcaacat cggcggctct ggatgtctgg gcctgaattt ctctgcccct      180

gagcagcctc tgagcctgta cgagtgtgat agcaccctgg tgtccctgag atggcggtgc      240

aaccggaaga tgatcacagg ccctctgcag tactctgtgc aggtcgccca cgacaatacc      300

gtggtggcca gcagaaagta catccacaag tggatcagct acggcagcgg cggaggcgac      360

atctgtgaat acctgcacaa ggatctg                                          387


<210>  61
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR

<400>  61

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu 
    


<210>  62
<211>  1026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1

<400>  62
aagggcatct tcgtgatcca gagcgagagc ctgaagaagt gcatccaggc cggcaagagc       60

gtgctgaccc tggaaaattg caagcaggcc aacaagcaca tgctgtggaa atgggtgtcc      120

aaccacggcc tgttcaacat cggcggctct ggatgtctgg gcctgaattt ctctgcccct      180

gagcagcctc tgagcctgta cgagtgtgat agcaccctgg tgtccctgag atggcggtgc      240

aaccggaaga tgatcacagg ccctctgcag tactctgtgc aggtcgccca cgacaatacc      300

gtggtggcca gcagaaagta catccacaag tggatcagct acggcagcgg cggaggcgac      360

atctgtgaat acctgcacaa ggatctgcac accatcaagg gcaacaccca cggaatgccc      420

tgcatgttcc cgtttcagta caaccaccag tggcaccacg agtgcaccag agaaggcaga      480

gaggacgacc tgctttggtg cgccacaacc agcagatacg agcgggatga gaagtggggc      540

ttctgccctg atcctacctc tgccgaagtg ggctgcgata ccatctggga gaaagacctg      600

aacagccaca tctgctacca gttcaacctg ctgtccagcc tgtcttggag cgaggcccac      660

agcagctgtc aaatgcaagg cggcacactg ctgagcatca ccgacgagac agaggaaaac      720

ttcatccgcg agcacatgag cagcaagacc gtggaagtgt ggatgggact gaaccagctg      780

gatgagcatg ccggatggca gtggagtgat ggcacccctc tgaactacct gaactggtcc      840

cctgaagtga acttcgagcc cttcgtggaa gatcactgcg gcaccttcag cagcttcatg      900

cccagcgctt ggagaagcag agactgcgag agcaccctgc cttacatctg caagaagtac      960

ctgaaccaca tcgaccacga gatcgtggaa aaggacgcct ggaagtacta cgccacacac     1020

tgcgag                                                                1026


<210>  63
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysR-FNII-CTLD1

<400>  63

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Lys Asp Ala Trp Lys Tyr 
                325                 330                 335     


Tyr Ala Thr His Cys Glu 
            340         


<210>  64
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  64
ttcgtgccgg tcttcctgcc agcgaagcca accacgacgc cagcaccgcg accaccaaca       60

cctgcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg cagaccagca      120

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgat                      165


<210>  65
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R Signal peptide

<400>  65
atgctgctga gccctagcct gctgctgctc ctgcttcttg gagcccctag aggatgtgcc       60


<210>  66
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  66
aagcgcggtc gcaagaaact gctctatatt tttaaacagc cattcatgag acctgtccag       60

accactcaag aggaggacgg atgttcctgt agatttcctg aagaggaaga gggggggtgc      120

gagctg                                                                 126


<210>  67
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLA2R pro-peptide

<400>  67
ggatctgaag gtgttgccgc cgctctgaca cccgagagac tgctggaatg gcaggac          57


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  68
ggtggcggag gttctggagg tggaggttcc                                        30


<210>  69
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  69
ggggsggggs                                                              10


<210>  70
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domains of Construct 4027.CF12

<400>  70

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Lys Asp Ala Trp Lys Tyr 
                325                 330                 335     


Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro Tyr Asn Arg Asn Cys 
            340                 345                 350         


Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His Glu Ala Leu Arg Ser 
        355                 360                 365             


Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile Thr Ser Leu Ala Glu 
    370                 375                 380                 


Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu Asn Ala Ser Glu Thr 
385                 390                 395                 400 


Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val Ser Phe Glu Trp Ser 
                405                 410                 415     


Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu Glu Pro His 
            420                 425                 430         


Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu Gln Ser Glu 
        435                 440                 445             


Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg Leu Phe Tyr Ile Cys 
    450                 455                 460                 


Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu Ser Gly Cys Gln 
465                 470                 475                 


<210>  71
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domains of Construct 4028.CF123

<400>  71

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys Gln Ala Asn Lys 
            20                  25                  30          


His Met Leu Trp Lys Trp Val Ser Asn His Gly Leu Phe Asn Ile Gly 
        35                  40                  45              


Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala Pro Glu Gln Pro Leu 
    50                  55                  60                  


Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg Cys 
65                  70                  75                  80  


Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val Ala 
                85                  90                  95      


His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp Ile 
            100                 105                 110         


Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu Tyr Leu His Lys Asp 
        115                 120                 125             


Leu His Thr Ile Lys Gly Asn Thr His Gly Met Pro Cys Met Phe Pro 
    130                 135                 140                 


Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg Glu Gly Arg 
145                 150                 155                 160 


Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser Arg Tyr Glu Arg Asp 
                165                 170                 175     


Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu Val Gly Cys 
            180                 185                 190         


Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe 
        195                 200                 205             


Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser Ser Cys Gln 
    210                 215                 220                 


Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp Glu Thr Glu Glu Asn 
225                 230                 235                 240 


Phe Ile Arg Glu His Met Ser Ser Lys Thr Val Glu Val Trp Met Gly 
                245                 250                 255     


Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln Trp Ser Asp Gly Thr 
            260                 265                 270         


Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val Asn Phe Glu Pro Phe 
        275                 280                 285             


Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe Met Pro Ser Ala Trp 
    290                 295                 300                 


Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr 
305                 310                 315                 320 


Leu Asn His Ile Asp His Glu Ile Val Glu Lys Asp Ala Trp Lys Tyr 
                325                 330                 335     


Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro Tyr Asn Arg Asn Cys 
            340                 345                 350         


Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His Glu Ala Leu Arg Ser 
        355                 360                 365             


Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile Thr Ser Leu Ala Glu 
    370                 375                 380                 


Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu Asn Ala Ser Glu Thr 
385                 390                 395                 400 


Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val Ser Phe Glu Trp Ser 
                405                 410                 415     


Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu Glu Pro His 
            420                 425                 430         


Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu Gln Ser Glu 
        435                 440                 445             


Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg Leu Phe Tyr Ile Cys 
    450                 455                 460                 


Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu Ser Gly Cys Gln Glu 
465                 470                 475                 480 


Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp Thr Val Leu 
                485                 490                 495     


Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr Cys Pro Pro Ala Leu 
            500                 505                 510         


Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile 
        515                 520                 525             


Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe Trp Ile Ala Leu Gln 
    530                 535                 540                 


Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Pro Val Gly Gln Lys 
545                 550                 555                 560 


Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr His Gln Pro Arg Tyr 
                565                 570                 575     


Ser Gly Gly Cys Val Ala Met Arg Gly Arg His Pro Leu Gly Arg Trp 
            580                 585                 590         


Glu Val Lys His Cys Arg His Phe Lys Ala Met Ser Leu Cys Lys Gln 
        595                 600                 605             


Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu Glu Arg Trp Pro Phe 
    610                 615                 620                 


His Pro Cys Tyr Leu 
625                 


<210>  72
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular domain

<400>  72
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


