                         SEQUENCE LISTING

<110>  Invista S.a.r.l.
       Foster, Alexander
       Kennedy, Jonathan
 
<120>  MATERIALS AND METHODS FOR CONTROLLING REGULATION IN BIOSYNTHESIS 
       IN SPECIES OF THE GENERA RALSTONIA OR CUPRIAVIDUS AND ORGANISMS 
       RELATED THERETO

<130>  INV0187WO

<150>  US 62/665,790
<151>  2018-05-02

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  C. necator


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  1
aatngwacga ycgtkcknwt                                                   20


<210>  2
<211>  97
<212>  DNA
<213>  C. necator

<400>  2
ttgtttgcga tccgctaacc ggtcaagccg tgtcgcggaa ggttgaataa cccgctgaac       60

tccggcattc ccggagaata gtgagcgtcc catgatg                                97


<210>  3
<211>  339
<212>  DNA
<213>  C. necator

<400>  3
atgaaactca tcatcgcagt catcaagccg ttcaagctcg acgaagtgcg cgaagcgctg       60

tcggacgtgg gcgtgtccgg cattaccgtg accgaagtga aaggcttcgg ccgccagaag      120

ggccacaccg agctgtaccg cggcgccgaa tacatcgtcg acttcctgcc caaggtgaag      180

atcgaggtgg cggtgcccga cgacgtggtc gagcgcgcca tcgaggcggt cgagaaatcg      240

gcccgcaccg gcaagatcgg cgacggcaag atcttcgtgg caccgatcga gcaggtcatc      300

cgcatccgca ccggcgagac cggcggcgat gccctgtga                             339


<210>  4
<211>  112
<212>  PRT
<213>  C. necator

<400>  4

Met Lys Leu Ile Ile Ala Val Ile Lys Pro Phe Lys Leu Asp Glu Val 
1               5                   10                  15      


Arg Glu Ala Leu Ser Asp Val Gly Val Ser Gly Ile Thr Val Thr Glu 
            20                  25                  30          


Val Lys Gly Phe Gly Arg Gln Lys Gly His Thr Glu Leu Tyr Arg Gly 
        35                  40                  45              


Ala Glu Tyr Ile Val Asp Phe Leu Pro Lys Val Lys Ile Glu Val Ala 
    50                  55                  60                  


Val Pro Asp Asp Val Val Glu Arg Ala Ile Glu Ala Val Glu Lys Ser 
65                  70                  75                  80  


Ala Arg Thr Gly Lys Ile Gly Asp Gly Lys Ile Phe Val Ala Pro Ile 
                85                  90                  95      


Glu Gln Val Ile Arg Ile Arg Thr Gly Glu Thr Gly Gly Asp Ala Leu 
            100                 105                 110         


<210>  5
<211>  456
<212>  DNA
<213>  C. necator

<400>  5
atggcaggca ttctgatcat cgcgcacacc ccgctggctt cggcgctgcg cgattgcgcc       60

gcccacgtct actgcggcca gccgcagcgg ctggaatcca tcgacgtcct tcccgatgcc      120

gaccccgccg tcgtgctggc cgaggccagg cgccggctgg cggccatctg cgaggacaac      180

ggcgcgctgg tcctcaccga tatcttcggc gccacccccg ccaatattgc cgcacgcctg      240

gccgagccgg gccgcgtgcg ggtgctggcc ggcgtcaacc ttcccatgct cgtgcgcgcg      300

atctgctacc gcggcgaaaa gctcgaccag cttgccacca aggccctggc cggcggctcg      360

cagggtgtgc tgcaggtcgg caccacgact gtccagaacc aaaccgcaaa ccatcccgac      420

aaatatgctg cagagggaca ccaccatcat caataa                                456


<210>  6
<211>  151
<212>  PRT
<213>  C. necator

<400>  6

Met Ala Gly Ile Leu Ile Ile Ala His Thr Pro Leu Ala Ser Ala Leu 
1               5                   10                  15      


Arg Asp Cys Ala Ala His Val Tyr Cys Gly Gln Pro Gln Arg Leu Glu 
            20                  25                  30          


Ser Ile Asp Val Leu Pro Asp Ala Asp Pro Ala Val Val Leu Ala Glu 
        35                  40                  45              


Ala Arg Arg Arg Leu Ala Ala Ile Cys Glu Asp Asn Gly Ala Leu Val 
    50                  55                  60                  


Leu Thr Asp Ile Phe Gly Ala Thr Pro Ala Asn Ile Ala Ala Arg Leu 
65                  70                  75                  80  


Ala Glu Pro Gly Arg Val Arg Val Leu Ala Gly Val Asn Leu Pro Met 
                85                  90                  95      


Leu Val Arg Ala Ile Cys Tyr Arg Gly Glu Lys Leu Asp Gln Leu Ala 
            100                 105                 110         


Thr Lys Ala Leu Ala Gly Gly Ser Gln Gly Val Leu Gln Val Gly Thr 
        115                 120                 125             


Thr Thr Val Gln Asn Gln Thr Ala Asn His Pro Asp Lys Tyr Ala Ala 
    130                 135                 140                 


Glu Gly His His His His Gln 
145                 150     


<210>  7
<211>  270
<212>  DNA
<213>  C. necator

<400>  7
atgctgcaga gggacaccac catcatcaat aaactcggcc tgcatgcgcg cgcgtccgcc       60

aagctgaccc agctcgccgg caactttgtc agccaggtca agatgtcccg caatggtcgc      120

caggtcgacg ccaagagcat catgggcgtc atgatgctgg ccgccgggat cggctcgacg      180

gtgaccctcg agaccgacgg ccccgacgag caggaggcga tggacgcgct gctggcgctg      240

atcgccaacc gctttggtga gggagagtga                                       270


<210>  8
<211>  89
<212>  PRT
<213>  C. necator

<400>  8

Met Leu Gln Arg Asp Thr Thr Ile Ile Asn Lys Leu Gly Leu His Ala 
1               5                   10                  15      


Arg Ala Ser Ala Lys Leu Thr Gln Leu Ala Gly Asn Phe Val Ser Gln 
            20                  25                  30          


Val Lys Met Ser Arg Asn Gly Arg Gln Val Asp Ala Lys Ser Ile Met 
        35                  40                  45              


Gly Val Met Met Leu Ala Ala Gly Ile Gly Ser Thr Val Thr Leu Glu 
    50                  55                  60                  


Thr Asp Gly Pro Asp Glu Gln Glu Ala Met Asp Ala Leu Leu Ala Leu 
65                  70                  75                  80  


Ile Ala Asn Arg Phe Gly Glu Gly Glu 
                85                  


<210>  9
<211>  1761
<212>  DNA
<213>  C. necator

<400>  9
atgcctttcg ccctgcacgg catcccggtc tcgcgcggcg tcgccatcgg gcgcgcgcac       60

ctgcttgcgc ccgcggcgct ggacgtgtcg cactacctgg tcgatgaaga ccagctcgac      120

gccgaggtcg aacggctgcg cgcagcgcgc gccgcggtgc gggcggagct ggccgcgctc      180

aagcgcgacc tgccgcgcga tgcgcccgag gagctgggcg cattcctgga cgtgcacgcg      240

atgatcctcg acgacgaggc gctggcgcgc gagcccgagg ccctgatccg gggccgccgc      300

tacaacgcag agtgggcact taccacgcgc ctcgaagagc tgatgcgcca gttcgacgag      360

atcgaggatg aatacctgcg cgagcgcaag accgatatcc ggcaggtggt cgagcgcatc      420

ctgaaggcgc tcgccggggc tccggtgctg gtgcccgcgc cggtgccggc gctggccgcc      480

gacggcgagg ccgcgaccgg ggtgatcgtg gtggcccacg atatcgcccc ggccgacatg      540

ctgcagttcc gccataccgt cttccacggc ttcgtcaccg acatgggcgg acgcacctcg      600

cataccgcca tcgtcgcgcg cagcctggac atcccggccg cggtcggcgt gcagagcgcg      660

agcgagctga tccgccagga cgactggatc atcatcgacg gcgatgccgg gctggtgatc      720

gtcgacccga ccgccatcat cctggaagag taccgccacc ggcagagcga gcgcgcgctg      780

gaaaagaagc gcctgcagcg gctgcggcat accccggcgg tgacgctgga cgggctggaa      840

atcgacctgc tggccaatat cgagatggcc gaggacgccg gcgcggcgct ggcggccggc      900

gcggtcggcg tgggcctgtt ccgttccgaa ttcctgttca tgaaccggcg cgacgagttg      960

ccgggcgagg acgagcagtt ccaggcctac cgcggcgcgg tcgatgccat gcacgggctg     1020

ccggtgacta tccgcaccat cgacatcggc gccgacaagc cgctcgatgc ccgcggcgat     1080

gaattcgaga ccgcgctgaa cccggcgctg ggcctgcgcg cgatccgctg gtcgctgtcc     1140

gagccgggca tgttcctgac ccagctgcgc gcgctgctgc gggcttcggc cttcggcccg     1200

gtgcggctgc tggtgccgat gctggcgcat gccagcgaga tcgaccagac cctggcgctg     1260

atcgccaagg ccaagcgcca gctcgacgag cgcggcgagg cctatgaccc gggcatgaag     1320

gtcggcgcca tgatcgagat cccggcggcg gtgctgctgc tgccgctgtt cctgcgcaag     1380

atggacttcc tgtccatcgg caccaacgac ctgatccagt acacgctggc catcgatcgc     1440

gccgacaacg cggtggcgca cctgttcgac ccgctgcacc cggcggtgct gcagctggtg     1500

gcgcgcacca tccgcgaggc caaccgcgcc ggcgtgccgg tggccgtgtg cggcgaaatg     1560

gcgggcgacc cgtccatgac ccggctgctg ctgggcatgg ggctgcgcga gttctcgatg     1620

cacccggcgc agctgctgcg ggtcaagcag gagatcctgc atgcccactg cgaacggctc     1680

gagccgctgg tcgaccaggt cctgcaggcc ttcgatcccg aggagcaggc ggccgccctg     1740

cggcagctgg cacgaccctg a                                               1761


<210>  10
<211>  586
<212>  PRT
<213>  C. necator

<400>  10

Met Pro Phe Ala Leu His Gly Ile Pro Val Ser Arg Gly Val Ala Ile 
1               5                   10                  15      


Gly Arg Ala His Leu Leu Ala Pro Ala Ala Leu Asp Val Ser His Tyr 
            20                  25                  30          


Leu Val Asp Glu Asp Gln Leu Asp Ala Glu Val Glu Arg Leu Arg Ala 
        35                  40                  45              


Ala Arg Ala Ala Val Arg Ala Glu Leu Ala Ala Leu Lys Arg Asp Leu 
    50                  55                  60                  


Pro Arg Asp Ala Pro Glu Glu Leu Gly Ala Phe Leu Asp Val His Ala 
65                  70                  75                  80  


Met Ile Leu Asp Asp Glu Ala Leu Ala Arg Glu Pro Glu Ala Leu Ile 
                85                  90                  95      


Arg Gly Arg Arg Tyr Asn Ala Glu Trp Ala Leu Thr Thr Arg Leu Glu 
            100                 105                 110         


Glu Leu Met Arg Gln Phe Asp Glu Ile Glu Asp Glu Tyr Leu Arg Glu 
        115                 120                 125             


Arg Lys Thr Asp Ile Arg Gln Val Val Glu Arg Ile Leu Lys Ala Leu 
    130                 135                 140                 


Ala Gly Ala Pro Val Leu Val Pro Ala Pro Val Pro Ala Leu Ala Ala 
145                 150                 155                 160 


Asp Gly Glu Ala Ala Thr Gly Val Ile Val Val Ala His Asp Ile Ala 
                165                 170                 175     


Pro Ala Asp Met Leu Gln Phe Arg His Thr Val Phe His Gly Phe Val 
            180                 185                 190         


Thr Asp Met Gly Gly Arg Thr Ser His Thr Ala Ile Val Ala Arg Ser 
        195                 200                 205             


Leu Asp Ile Pro Ala Ala Val Gly Val Gln Ser Ala Ser Glu Leu Ile 
    210                 215                 220                 


Arg Gln Asp Asp Trp Ile Ile Ile Asp Gly Asp Ala Gly Leu Val Ile 
225                 230                 235                 240 


Val Asp Pro Thr Ala Ile Ile Leu Glu Glu Tyr Arg His Arg Gln Ser 
                245                 250                 255     


Glu Arg Ala Leu Glu Lys Lys Arg Leu Gln Arg Leu Arg His Thr Pro 
            260                 265                 270         


Ala Val Thr Leu Asp Gly Leu Glu Ile Asp Leu Leu Ala Asn Ile Glu 
        275                 280                 285             


Met Ala Glu Asp Ala Gly Ala Ala Leu Ala Ala Gly Ala Val Gly Val 
    290                 295                 300                 


Gly Leu Phe Arg Ser Glu Phe Leu Phe Met Asn Arg Arg Asp Glu Leu 
305                 310                 315                 320 


Pro Gly Glu Asp Glu Gln Phe Gln Ala Tyr Arg Gly Ala Val Asp Ala 
                325                 330                 335     


Met His Gly Leu Pro Val Thr Ile Arg Thr Ile Asp Ile Gly Ala Asp 
            340                 345                 350         


Lys Pro Leu Asp Ala Arg Gly Asp Glu Phe Glu Thr Ala Leu Asn Pro 
        355                 360                 365             


Ala Leu Gly Leu Arg Ala Ile Arg Trp Ser Leu Ser Glu Pro Gly Met 
    370                 375                 380                 


Phe Leu Thr Gln Leu Arg Ala Leu Leu Arg Ala Ser Ala Phe Gly Pro 
385                 390                 395                 400 


Val Arg Leu Leu Val Pro Met Leu Ala His Ala Ser Glu Ile Asp Gln 
                405                 410                 415     


Thr Leu Ala Leu Ile Ala Lys Ala Lys Arg Gln Leu Asp Glu Arg Gly 
            420                 425                 430         


Glu Ala Tyr Asp Pro Gly Met Lys Val Gly Ala Met Ile Glu Ile Pro 
        435                 440                 445             


Ala Ala Val Leu Leu Leu Pro Leu Phe Leu Arg Lys Met Asp Phe Leu 
    450                 455                 460                 


Ser Ile Gly Thr Asn Asp Leu Ile Gln Tyr Thr Leu Ala Ile Asp Arg 
465                 470                 475                 480 


Ala Asp Asn Ala Val Ala His Leu Phe Asp Pro Leu His Pro Ala Val 
                485                 490                 495     


Leu Gln Leu Val Ala Arg Thr Ile Arg Glu Ala Asn Arg Ala Gly Val 
            500                 505                 510         


Pro Val Ala Val Cys Gly Glu Met Ala Gly Asp Pro Ser Met Thr Arg 
        515                 520                 525             


Leu Leu Leu Gly Met Gly Leu Arg Glu Phe Ser Met His Pro Ala Gln 
    530                 535                 540                 


Leu Leu Arg Val Lys Gln Glu Ile Leu His Ala His Cys Glu Arg Leu 
545                 550                 555                 560 


Glu Pro Leu Val Asp Gln Val Leu Gln Ala Phe Asp Pro Glu Glu Gln 
                565                 570                 575     


Ala Ala Ala Leu Arg Gln Leu Ala Arg Pro 
            580                 585     


<210>  11
<211>  972
<212>  DNA
<213>  C. necator

<400>  11
atggaactca ccggcgtcac ctcccagtcc atcttcgacg acaacgcagc cgacatcaaa       60

ctctcgtggg tggccggcct ggaaggtgcg gatcgcgcct tcgatgtgga gttcgcccgc      120

gaagccacct ccgccgccga cctggtgggc cacctgaacc tgatccaccc caaccgcatc      180

caggtgctcg gcaagcccga gatcacttat taccagcgac tggacgacga gacccgcaag      240

cgccagatgg gcgagctgat cctgctggag ccgcccttcc tggtgatcgc cgacggcatg      300

gagccgccgc ccgacctgga actgcgctgc acgcgctcgt ccacgccgct gttcaccacg      360

ccggtgtcgt cggccgcggt gatcgaccac ctgcgcctgt acctgtcgcg tatctccgcg      420

ccgcgcgtga ccatgcacgg ggtattcctc gacatcctgg gcatgggcgt gctgatcatg      480

ggcgaatcgg gcctgggcaa gagcgaactg ggcctggaac tgatctcgcg cggccacggg      540

ctggtggccg atgatgccgt ggacttcgtg cgcctggggc cggatttcat tgaaggccgc      600

tgcccgccgc tgctgcagaa cctgcttgaa gtacgcggtc tgggcctgct cgacatcaag      660

accatcttcg gtgagaccgc ggtgcgccgg aagatgaaga tcaagctggt ggtgcagttg      720

gtgcgtcgca atgacggcga gttcgagcgg ctgccgctcg attcgcaata cctcgacgtg      780

ctgggcctgc cgatccacat ggtcaagatc caggtggcgg ccgggcgcaa cctggccgtg      840

ctggtcgagg ccgcggtgcg caacaccatc ctgcgcctgc gcggcatcga tacgctgcgc      900

gacttcatgg accggcagcg cgccgcgatg caggccgatg cagtatcgcg cggccagggc      960

cgcttgctct ga                                                          972


<210>  12
<211>  323
<212>  PRT
<213>  C. necator

<400>  12

Met Glu Leu Thr Gly Val Thr Ser Gln Ser Ile Phe Asp Asp Asn Ala 
1               5                   10                  15      


Ala Asp Ile Lys Leu Ser Trp Val Ala Gly Leu Glu Gly Ala Asp Arg 
            20                  25                  30          


Ala Phe Asp Val Glu Phe Ala Arg Glu Ala Thr Ser Ala Ala Asp Leu 
        35                  40                  45              


Val Gly His Leu Asn Leu Ile His Pro Asn Arg Ile Gln Val Leu Gly 
    50                  55                  60                  


Lys Pro Glu Ile Thr Tyr Tyr Gln Arg Leu Asp Asp Glu Thr Arg Lys 
65                  70                  75                  80  


Arg Gln Met Gly Glu Leu Ile Leu Leu Glu Pro Pro Phe Leu Val Ile 
                85                  90                  95      


Ala Asp Gly Met Glu Pro Pro Pro Asp Leu Glu Leu Arg Cys Thr Arg 
            100                 105                 110         


Ser Ser Thr Pro Leu Phe Thr Thr Pro Val Ser Ser Ala Ala Val Ile 
        115                 120                 125             


Asp His Leu Arg Leu Tyr Leu Ser Arg Ile Ser Ala Pro Arg Val Thr 
    130                 135                 140                 


Met His Gly Val Phe Leu Asp Ile Leu Gly Met Gly Val Leu Ile Met 
145                 150                 155                 160 


Gly Glu Ser Gly Leu Gly Lys Ser Glu Leu Gly Leu Glu Leu Ile Ser 
                165                 170                 175     


Arg Gly His Gly Leu Val Ala Asp Asp Ala Val Asp Phe Val Arg Leu 
            180                 185                 190         


Gly Pro Asp Phe Ile Glu Gly Arg Cys Pro Pro Leu Leu Gln Asn Leu 
        195                 200                 205             


Leu Glu Val Arg Gly Leu Gly Leu Leu Asp Ile Lys Thr Ile Phe Gly 
    210                 215                 220                 


Glu Thr Ala Val Arg Arg Lys Met Lys Ile Lys Leu Val Val Gln Leu 
225                 230                 235                 240 


Val Arg Arg Asn Asp Gly Glu Phe Glu Arg Leu Pro Leu Asp Ser Gln 
                245                 250                 255     


Tyr Leu Asp Val Leu Gly Leu Pro Ile His Met Val Lys Ile Gln Val 
            260                 265                 270         


Ala Ala Gly Arg Asn Leu Ala Val Leu Val Glu Ala Ala Val Arg Asn 
        275                 280                 285             


Thr Ile Leu Arg Leu Arg Gly Ile Asp Thr Leu Arg Asp Phe Met Asp 
    290                 295                 300                 


Arg Gln Arg Ala Ala Met Gln Ala Asp Ala Val Ser Arg Gly Gln Gly 
305                 310                 315                 320 


Arg Leu Leu 
            


<210>  13
<211>  456
<212>  DNA
<213>  C. necator

<400>  13
atgaatcgtt tggccaaatt gctgccaccc ggcaacatca ccctcgacgt cagcgtcacc       60

agcaagaagc gtgtgttcga gcaggccggg ctcctcttcg agaacaacca tggtgtggcg      120

cgcgccatcg tgacggacaa cctgttcgcg cgcgagtcgc ttggatccac cggcctgggc      180

gccggcgtgg caatcccgca cggccgcatc aagggcctga agcagccgct ggccgcgttc      240

atgcgcctgg ccgaaccaat tccgttcgaa tcgcccgatg gcaagccggt atcgctgctg      300

atcttcctgc tggtgcccga acaggctacg cagcagcacc tggaaatcct gtccgaaatc      360

gcgcaactgc tttccgaccg cgacatgcgt gaagggctgg ccacgctgcc cacgcccgat      420

gccgtccatc agttgctgat cgcatggcat ccctga                                456


<210>  14
<211>  151
<212>  PRT
<213>  C. necator

<400>  14

Met Asn Arg Leu Ala Lys Leu Leu Pro Pro Gly Asn Ile Thr Leu Asp 
1               5                   10                  15      


Val Ser Val Thr Ser Lys Lys Arg Val Phe Glu Gln Ala Gly Leu Leu 
            20                  25                  30          


Phe Glu Asn Asn His Gly Val Ala Arg Ala Ile Val Thr Asp Asn Leu 
        35                  40                  45              


Phe Ala Arg Glu Ser Leu Gly Ser Thr Gly Leu Gly Ala Gly Val Ala 
    50                  55                  60                  


Ile Pro His Gly Arg Ile Lys Gly Leu Lys Gln Pro Leu Ala Ala Phe 
65                  70                  75                  80  


Met Arg Leu Ala Glu Pro Ile Pro Phe Glu Ser Pro Asp Gly Lys Pro 
                85                  90                  95      


Val Ser Leu Leu Ile Phe Leu Leu Val Pro Glu Gln Ala Thr Gln Gln 
            100                 105                 110         


His Leu Glu Ile Leu Ser Glu Ile Ala Gln Leu Leu Ser Asp Arg Asp 
        115                 120                 125             


Met Arg Glu Gly Leu Ala Thr Leu Pro Thr Pro Asp Ala Val His Gln 
    130                 135                 140                 


Leu Leu Ile Ala Trp His Pro 
145                 150     


<210>  15
<211>  351
<212>  DNA
<213>  C. necator

<400>  15
atgaacttca agatcagtgg acaccacctg gacatcacgc cccctctgcg tgagtacgtg       60

gaaacgaagc tggagcgaat cgtcaggcat ttcgatcaag tcattggcgt tagtgtgctg      120

ctctctgtcg acaaccacaa ggaaaaggac cggcgtcagt acgcggaaat caatctacat      180

ctcaagggca aggacatctt tgtcgaagcg catcacgaag acctgtatgc agcgatcgac      240

gcactcgtcg acaagctgga ccgtcaggtg atccgctaca aggatcgcgt gcaaggccac      300

gaccgcgaag cggtcaagta ccagatggcc gcagcgcaaa tgcagcaatg a               351


<210>  16
<211>  116
<212>  PRT
<213>  C. necator

<400>  16

Met Asn Phe Lys Ile Ser Gly His His Leu Asp Ile Thr Pro Pro Leu 
1               5                   10                  15      


Arg Glu Tyr Val Glu Thr Lys Leu Glu Arg Ile Val Arg His Phe Asp 
            20                  25                  30          


Gln Val Ile Gly Val Ser Val Leu Leu Ser Val Asp Asn His Lys Glu 
        35                  40                  45              


Lys Asp Arg Arg Gln Tyr Ala Glu Ile Asn Leu His Leu Lys Gly Lys 
    50                  55                  60                  


Asp Ile Phe Val Glu Ala His His Glu Asp Leu Tyr Ala Ala Ile Asp 
65                  70                  75                  80  


Ala Leu Val Asp Lys Leu Asp Arg Gln Val Ile Arg Tyr Lys Asp Arg 
                85                  90                  95      


Val Gln Gly His Asp Arg Glu Ala Val Lys Tyr Gln Met Ala Ala Ala 
            100                 105                 110         


Gln Met Gln Gln 
        115     


<210>  17
<211>  1482
<212>  DNA
<213>  C. necator

<400>  17
atgaaaccgt cgctacagct ccgcctttcc cagcatctgg ccctgacccc gcaactgcag       60

cagtcgatcc ggctgctgca gctttccacg ctggaactgc agcaagaggt cgaacaggca      120

ctgacggaaa accctctgct cgaacgcgag aacgactgga tcgaaagccc gctgcgcgtg      180

gcggccgacg gctcggtcaa cctgcagagc gcaccggcgc ccgcgccggc agagccgcag      240

ggcaatggcg aggcccgcgc cgacggcgcg gctgacgacg acagctatgg cgacagcggc      300

aacggcgacg actatggcag cagcgactgg agcctggacg actttgcccg ccgcccccag      360

ggcgacgagg acgaaaaaac gccgatgcag ctgcgcgaag ccgagcccac gctgcgcgag      420

tacctgatgg aacagctcac gccgctgaag atctcggcgc gcgacaaggg cctggccatc      480

ttcctgatcg aatcgctcga cgacgatggc tacctgagcg catcgcttga ggagatctgc      540

acggagttgc cggaagaact cgagttcgag atcgaggagg tccacgccat cctcacgctg      600

ctgcagagct tcgacccgcc cggcgtgggc gcgcgcaacg ccgccgagtg cctggccctg      660

cagttgcggc gcctgacgca cccgcagcgc gaactggccc tgaacatcgt gaccaaccac      720

ctggagttgc tcgcagtacg cgactacacg cggctgaaga aggcgctgca ggtggatgaa      780

gcggcgctga agtccgcaca cgaactgatc cgctcgctgg cgccctaccc cggccatgca      840

tacagccgcc cggaggcgga cttcgtggtg ccggacgtgt tcgtgcgcaa gggtggcggc      900

ggctggatcg cgcagctcaa tccggatgtg atgccgaggc tgcgcatcaa tgacatgtat      960

gcgcaaatcc tacgtggcgc aaagggtgag tccggcaccg ccgggctgca gcagaagctg     1020

caagaggcgc gctggctgat caagaacatc cagcagaggt tcgacaaaat cctgcgtgtc     1080

tcgcaggcca ttgtcgagcg tcaaaagaac tttttcagcc acggcgaaat cgccatgcgc     1140

cccttggttt tgcgggagat tgccgataca ctgggtttac acgagtcaac catctcccgg     1200

gtgacgacca ataaatatat ggcaacgccg atgggtactt tcgaactgaa gtacttcttc     1260

ggcagccacg tgtccaccga aaccggtggc gcggcttcgt caacggccat ccgcgccttg     1320

atcaagcaac tgataggagc cgaagacccg aggaatcccc tttccgacag tcgcattgcc     1380

gaactgctgg gcgaacaagg cttcgttgtc gcacgccgca ccgttgccaa gtatcgcgaa     1440

gccctgaaga tccccgcagt caatctccgc aagtctttgt ag                        1482


<210>  18
<211>  493
<212>  PRT
<213>  C. necator

<400>  18

Met Lys Pro Ser Leu Gln Leu Arg Leu Ser Gln His Leu Ala Leu Thr 
1               5                   10                  15      


Pro Gln Leu Gln Gln Ser Ile Arg Leu Leu Gln Leu Ser Thr Leu Glu 
            20                  25                  30          


Leu Gln Gln Glu Val Glu Gln Ala Leu Thr Glu Asn Pro Leu Leu Glu 
        35                  40                  45              


Arg Glu Asn Asp Trp Ile Glu Ser Pro Leu Arg Val Ala Ala Asp Gly 
    50                  55                  60                  


Ser Val Asn Leu Gln Ser Ala Pro Ala Pro Ala Pro Ala Glu Pro Gln 
65                  70                  75                  80  


Gly Asn Gly Glu Ala Arg Ala Asp Gly Ala Ala Asp Asp Asp Ser Tyr 
                85                  90                  95      


Gly Asp Ser Gly Asn Gly Asp Asp Tyr Gly Ser Ser Asp Trp Ser Leu 
            100                 105                 110         


Asp Asp Phe Ala Arg Arg Pro Gln Gly Asp Glu Asp Glu Lys Thr Pro 
        115                 120                 125             


Met Gln Leu Arg Glu Ala Glu Pro Thr Leu Arg Glu Tyr Leu Met Glu 
    130                 135                 140                 


Gln Leu Thr Pro Leu Lys Ile Ser Ala Arg Asp Lys Gly Leu Ala Ile 
145                 150                 155                 160 


Phe Leu Ile Glu Ser Leu Asp Asp Asp Gly Tyr Leu Ser Ala Ser Leu 
                165                 170                 175     


Glu Glu Ile Cys Thr Glu Leu Pro Glu Glu Leu Glu Phe Glu Ile Glu 
            180                 185                 190         


Glu Val His Ala Ile Leu Thr Leu Leu Gln Ser Phe Asp Pro Pro Gly 
        195                 200                 205             


Val Gly Ala Arg Asn Ala Ala Glu Cys Leu Ala Leu Gln Leu Arg Arg 
    210                 215                 220                 


Leu Thr His Pro Gln Arg Glu Leu Ala Leu Asn Ile Val Thr Asn His 
225                 230                 235                 240 


Leu Glu Leu Leu Ala Val Arg Asp Tyr Thr Arg Leu Lys Lys Ala Leu 
                245                 250                 255     


Gln Val Asp Glu Ala Ala Leu Lys Ser Ala His Glu Leu Ile Arg Ser 
            260                 265                 270         


Leu Ala Pro Tyr Pro Gly His Ala Tyr Ser Arg Pro Glu Ala Asp Phe 
        275                 280                 285             


Val Val Pro Asp Val Phe Val Arg Lys Gly Gly Gly Gly Trp Ile Ala 
    290                 295                 300                 


Gln Leu Asn Pro Asp Val Met Pro Arg Leu Arg Ile Asn Asp Met Tyr 
305                 310                 315                 320 


Ala Gln Ile Leu Arg Gly Ala Lys Gly Glu Ser Gly Thr Ala Gly Leu 
                325                 330                 335     


Gln Gln Lys Leu Gln Glu Ala Arg Trp Leu Ile Lys Asn Ile Gln Gln 
            340                 345                 350         


Arg Phe Asp Lys Ile Leu Arg Val Ser Gln Ala Ile Val Glu Arg Gln 
        355                 360                 365             


Lys Asn Phe Phe Ser His Gly Glu Ile Ala Met Arg Pro Leu Val Leu 
    370                 375                 380                 


Arg Glu Ile Ala Asp Thr Leu Gly Leu His Glu Ser Thr Ile Ser Arg 
385                 390                 395                 400 


Val Thr Thr Asn Lys Tyr Met Ala Thr Pro Met Gly Thr Phe Glu Leu 
                405                 410                 415     


Lys Tyr Phe Phe Gly Ser His Val Ser Thr Glu Thr Gly Gly Ala Ala 
            420                 425                 430         


Ser Ser Thr Ala Ile Arg Ala Leu Ile Lys Gln Leu Ile Gly Ala Glu 
        435                 440                 445             


Asp Pro Arg Asn Pro Leu Ser Asp Ser Arg Ile Ala Glu Leu Leu Gly 
    450                 455                 460                 


Glu Gln Gly Phe Val Val Ala Arg Arg Thr Val Ala Lys Tyr Arg Glu 
465                 470                 475                 480 


Ala Leu Lys Ile Pro Ala Val Asn Leu Arg Lys Ser Leu 
                485                 490             


<210>  19
<211>  591
<212>  DNA
<213>  C. necator

<400>  19
atgcgcaagg gtgaaatgac gcgcgtggcg attctggatg ccgcactgga attgtcgtcc       60

cgcgacgggc tcgaaggtct gaccatcggg ctgctcgcgg aacgcatgca gatgagcaag      120

agcggtgtct tcgcgcattt cggttcgcgc gaagacctgc aggtggaggt ggtgcgggag      180

tatcaccgcc ggttcgagca ggaggtgttc tatccctcgc tgcaggagcc gcgcggcctg      240

ccccggctat ggtcgatggt gcggcgctgg atggagaagc gcatccagga agtgacgact      300

ggatgcatct acatcagcgg cgccgtggag tacgacgacc gtgccggcag cctggtgcgt      360

gacgagctgg tcaagagcgt caccatctgg cgggcagcgc tcacgcgcgc catcaaccag      420

gcgcgggagg aagggcacct gcgcgcggac tgcgatccgc gcctgatgct gttcgagatg      480

tacagccttg aactaggctt gcatcatgac gcccgtttcc tgcgcctgcc tgacagtgcc      540

gagcttgcca tggtcgcgct caacaagctg attcagtctt accgtacctg a               591


<210>  20
<211>  196
<212>  PRT
<213>  C. necator

<400>  20

Met Arg Lys Gly Glu Met Thr Arg Val Ala Ile Leu Asp Ala Ala Leu 
1               5                   10                  15      


Glu Leu Ser Ser Arg Asp Gly Leu Glu Gly Leu Thr Ile Gly Leu Leu 
            20                  25                  30          


Ala Glu Arg Met Gln Met Ser Lys Ser Gly Val Phe Ala His Phe Gly 
        35                  40                  45              


Ser Arg Glu Asp Leu Gln Val Glu Val Val Arg Glu Tyr His Arg Arg 
    50                  55                  60                  


Phe Glu Gln Glu Val Phe Tyr Pro Ser Leu Gln Glu Pro Arg Gly Leu 
65                  70                  75                  80  


Pro Arg Leu Trp Ser Met Val Arg Arg Trp Met Glu Lys Arg Ile Gln 
                85                  90                  95      


Glu Val Thr Thr Gly Cys Ile Tyr Ile Ser Gly Ala Val Glu Tyr Asp 
            100                 105                 110         


Asp Arg Ala Gly Ser Leu Val Arg Asp Glu Leu Val Lys Ser Val Thr 
        115                 120                 125             


Ile Trp Arg Ala Ala Leu Thr Arg Ala Ile Asn Gln Ala Arg Glu Glu 
    130                 135                 140                 


Gly His Leu Arg Ala Asp Cys Asp Pro Arg Leu Met Leu Phe Glu Met 
145                 150                 155                 160 


Tyr Ser Leu Glu Leu Gly Leu His His Asp Ala Arg Phe Leu Arg Leu 
                165                 170                 175     


Pro Asp Ser Ala Glu Leu Ala Met Val Ala Leu Asn Lys Leu Ile Gln 
            180                 185                 190         


Ser Tyr Arg Thr 
        195     


<210>  21
<211>  1308
<212>  DNA
<213>  C. necator

<400>  21
atgtcttccg cagcaccgac caatattgct ggccaaaagc acgcactccc gtcttacctc       60

aatgccgacc atctcggccc ctggggcatc tacctgcagc aggtcgaccg tgtcacgcct      120

tacctgggct cgctggcacg ctgggtcgaa accctcaagc gccccaagcg cgcgatgatc      180

gtcgacgttc ccatcgaact ggataacggc accattgccc atttcgaggg ctatcgggtg      240

cagcacaacc tgtcgcgcgg cccgggcaag ggcggcgtgc gcttccacca ggacgtgacc      300

ctgtccgagg tgatggcgct gtcggcctgg atgtcggtga agaatgccgc ggtcaacgtg      360

ccctacggcg gtgccaaggg cggcatccgc gtcgatccgc gcacgctctc gcacgccgag      420

ctggaacgcc tgacgcgccg ctacaccagc gaaatcaaca tcatcatcgg gccgagcaag      480

gatattccgg cgccggacgt gaacaccaac gcccaggtca tggcctggat gatggacacg      540

tactcgatga actccggcag cacggccacc ggcgtggtga ccggcaagcc gatctcgctg      600

ggcggctcgc tcggccgcca cgaagccacc ggccgcggcg tgttcgtggt cggctccgag      660

gccgcgcgca atatcggcct ggagatcaag ggcgcgcgcg tggcggtgca gggcttcggc      720

aacgtgggcg cggtggcggc caagctgttc catgaggccg gcgccaaggt ggtggcggtg      780

caggaccacc gcaccacgct gttcgacccg gccggcctgg acgtgccggc gatgatggaa      840

tacgcctcgc acagcggcac catcgaaggc ttccgcggcg aagtcctgcg caccgagcag      900

ttctgggaag tcgactgcga catcctgatc ccggccgcgc tggaaggcca gatcacggtg      960

cagaacgcgc ccaagatcac ggcaaagctg gtgattgaag gcgccaacgg cccgaccacg     1020

ccgcaagccg acgatatcct gcgcgagcgc aatatcctgg tctgtcccga cgtgatcgcc     1080

aacgccggcg gcgtgaccgt gtcctacttc gaatgggtgc aggatttctc cagctttttc     1140

tggaccgagg aagaaatcaa ccagcgcctg gtacggatca tgcaagaagc cttccgggca     1200

atctggcaag tggcacagga caacaaggtg acgctgcgca cggcggcgtt tatcgtggcc     1260

tgtacgcgga tcctgcaggc gcgcgagatg cgcggcctgt atccctga                  1308


<210>  22
<211>  435
<212>  PRT
<213>  C. necator

<400>  22

Met Ser Ser Ala Ala Pro Thr Asn Ile Ala Gly Gln Lys His Ala Leu 
1               5                   10                  15      


Pro Ser Tyr Leu Asn Ala Asp His Leu Gly Pro Trp Gly Ile Tyr Leu 
            20                  25                  30          


Gln Gln Val Asp Arg Val Thr Pro Tyr Leu Gly Ser Leu Ala Arg Trp 
        35                  40                  45              


Val Glu Thr Leu Lys Arg Pro Lys Arg Ala Met Ile Val Asp Val Pro 
    50                  55                  60                  


Ile Glu Leu Asp Asn Gly Thr Ile Ala His Phe Glu Gly Tyr Arg Val 
65                  70                  75                  80  


Gln His Asn Leu Ser Arg Gly Pro Gly Lys Gly Gly Val Arg Phe His 
                85                  90                  95      


Gln Asp Val Thr Leu Ser Glu Val Met Ala Leu Ser Ala Trp Met Ser 
            100                 105                 110         


Val Lys Asn Ala Ala Val Asn Val Pro Tyr Gly Gly Ala Lys Gly Gly 
        115                 120                 125             


Ile Arg Val Asp Pro Arg Thr Leu Ser His Ala Glu Leu Glu Arg Leu 
    130                 135                 140                 


Thr Arg Arg Tyr Thr Ser Glu Ile Asn Ile Ile Ile Gly Pro Ser Lys 
145                 150                 155                 160 


Asp Ile Pro Ala Pro Asp Val Asn Thr Asn Ala Gln Val Met Ala Trp 
                165                 170                 175     


Met Met Asp Thr Tyr Ser Met Asn Ser Gly Ser Thr Ala Thr Gly Val 
            180                 185                 190         


Val Thr Gly Lys Pro Ile Ser Leu Gly Gly Ser Leu Gly Arg His Glu 
        195                 200                 205             


Ala Thr Gly Arg Gly Val Phe Val Val Gly Ser Glu Ala Ala Arg Asn 
    210                 215                 220                 


Ile Gly Leu Glu Ile Lys Gly Ala Arg Val Ala Val Gln Gly Phe Gly 
225                 230                 235                 240 


Asn Val Gly Ala Val Ala Ala Lys Leu Phe His Glu Ala Gly Ala Lys 
                245                 250                 255     


Val Val Ala Val Gln Asp His Arg Thr Thr Leu Phe Asp Pro Ala Gly 
            260                 265                 270         


Leu Asp Val Pro Ala Met Met Glu Tyr Ala Ser His Ser Gly Thr Ile 
        275                 280                 285             


Glu Gly Phe Arg Gly Glu Val Leu Arg Thr Glu Gln Phe Trp Glu Val 
    290                 295                 300                 


Asp Cys Asp Ile Leu Ile Pro Ala Ala Leu Glu Gly Gln Ile Thr Val 
305                 310                 315                 320 


Gln Asn Ala Pro Lys Ile Thr Ala Lys Leu Val Ile Glu Gly Ala Asn 
                325                 330                 335     


Gly Pro Thr Thr Pro Gln Ala Asp Asp Ile Leu Arg Glu Arg Asn Ile 
            340                 345                 350         


Leu Val Cys Pro Asp Val Ile Ala Asn Ala Gly Gly Val Thr Val Ser 
        355                 360                 365             


Tyr Phe Glu Trp Val Gln Asp Phe Ser Ser Phe Phe Trp Thr Glu Glu 
    370                 375                 380                 


Glu Ile Asn Gln Arg Leu Val Arg Ile Met Gln Glu Ala Phe Arg Ala 
385                 390                 395                 400 


Ile Trp Gln Val Ala Gln Asp Asn Lys Val Thr Leu Arg Thr Ala Ala 
                405                 410                 415     


Phe Ile Val Ala Cys Thr Arg Ile Leu Gln Ala Arg Glu Met Arg Gly 
            420                 425                 430         


Leu Tyr Pro 
        435 


<210>  23
<211>  339
<212>  DNA
<213>  C. necator

<400>  23
atgaagcaga ttaccgccat catcaaaccg ttcaagctcg acgaggtgcg tgaagccctg       60

gccgacgtcg gcgtgaccgg tctgacggtg accgaagtga agggatttgg ccgccagaaa      120

gggcataccg agctctaccg tggcgccgag tacgtggtcg acttcctgcc caagatcaag      180

atcgaagtgg tggtggccga gaaccagctg gacaccgtgc tggacgccat cgtcaaggcc      240

gcccacaccg gcaagatcgg cgacggcaag atcttcgtca ccgagatcga gcgtgtgatc      300

cgcatccgca ccggcgagca ggacgaagcc gcggtctga                             339


<210>  24
<211>  112
<212>  PRT
<213>  C. necator

<400>  24

Met Lys Gln Ile Thr Ala Ile Ile Lys Pro Phe Lys Leu Asp Glu Val 
1               5                   10                  15      


Arg Glu Ala Leu Ala Asp Val Gly Val Thr Gly Leu Thr Val Thr Glu 
            20                  25                  30          


Val Lys Gly Phe Gly Arg Gln Lys Gly His Thr Glu Leu Tyr Arg Gly 
        35                  40                  45              


Ala Glu Tyr Val Val Asp Phe Leu Pro Lys Ile Lys Ile Glu Val Val 
    50                  55                  60                  


Val Ala Glu Asn Gln Leu Asp Thr Val Leu Asp Ala Ile Val Lys Ala 
65                  70                  75                  80  


Ala His Thr Gly Lys Ile Gly Asp Gly Lys Ile Phe Val Thr Glu Ile 
                85                  90                  95      


Glu Arg Val Ile Arg Ile Arg Thr Gly Glu Gln Asp Glu Ala Ala Val 
            100                 105                 110         


<210>  25
<211>  2412
<212>  DNA
<213>  C. necator

<400>  25
gtgaacgcgc gcaccggcgc tcccaatctt cccgatccgc tcggcgacga tgtcgtcggc       60

gagcgtgccg tcgcgcccgc gctggcgccg ggcaagtcca ggggcgcggc gctgcaggac      120

gagctggccg cgatgcagga tgtggcgccg gcggctgaca gcctgtttat cgacgcagtg      180

ctggcgcagt cataccggca cttcttcggc ccgacctcgc agccggcggt gccgccgcgc      240

cagcaggtca tctccatcac ccggctgatg gagaaactcg cgtacctgaa ggcgcccgac      300

ctggcgcgcg tgcgcgaggc cttccagttt tccgacgaag cccacctggg ccagtaccgc      360

cagagcggtg agccctacat cacccatccg gtggcggtgg ccgagctgtg cgcggactgg      420

aagctggatg tgcagtccat catggcggcg ctgctgcacg acgtgatgga agaccagggc      480

atcaccaaga gcgagctggt cgagaaattc ggccccaagg tcgccgaact ggtcgacggc      540

ctgaccaaat tggacaagct cgaattccag agccgcgagc aggcgcaggc ggagagcttc      600

cgcaagatgc tgctggcgat ggcgcgcgac gtgcgcgtga tcctggtgaa gctggccgac      660

cgtacgcaca acatgcgcac gctcgacttc gtcccgccgg agaagcgccg ccgcatcgcg      720

ctggagacca tggagatcta tgcgccgatc gcgcaccgtc tcggtctcaa cacgatctac      780

cgcgagctgc aggagctgtc cttcaaggtc ggctcgccgt tccgctacgc cacgctggaa      840

aaagccgtca aggccgcgcg cggcaaccgc cgcgaggtgg tcaagcgtat cctggaagcc      900

gcgcagaagg ggctggccga cgccggcatc gtggccgaac tgtccgggcg cgagaaaacg      960

ctctacagca tctaccgcaa gatgcacgac aagcagctgt cgttctcgca ggtgctggac     1020

gtatatggtt tccgcgtggt ggtggaaacg cagatgcact gctacatggc gatgggcgcg     1080

ctgcatgggc tgtacaagcc catgcccggc aagttcaagg actacatcgc catccccaag     1140

atcaacggct accagtcgct gcacaccacg ctggtgggtc cgttcggcac gccggtggag     1200

ttccagatcc gcacgcgcga catgcaccag atcgccgagg ccggcgtggc cgcgcactgg     1260

atgtacaagc accaggccga tcacgccaac gatatccagc agcaggcgca ccagtggctg     1320

cagtcgctgc tcgatatcca gagccagacc ggcgattcgc aggaattcct cgagcacgtc     1380

aagatcgacc tgttcccgga tgcggtctac gtgttcacgc ccaagggcca tatccgcgcg     1440

ctgccgcgcg gcgccaccgc gctggacttt gcctacgcgg tgcacagcga cctgggcaac     1500

cagtgcgtcg cggtcaagat caacaacgag atgttgccgc tgcgcaccga gctcaagagc     1560

ggcgatatcg tcgaggtggt gacggcgccg tactccaagc ccaatccggc gtggctgtcg     1620

ttcgtgcgca ccggcaaggc gcgcgcggcg atccgccact acctgaagac caccaagctc     1680

gacgaagcca tccagcttgg cgagcgcctg ctggaacagt cggcgcgcca gctcggcttc     1740

gagctcaagg cggtgccgca gtcggtgtgg gaccgcatgg tgcagtggac cggcaacaag     1800

cagcgcgaag acatctttgc cgacctggca ctgggccggc gcgtgccggc ggtggtggcc     1860

aagcgcatgg agatcctgct ccaggagctg tccggcgatg tcgacagcgc gctgctggcg     1920

gcggtgcaga ccttcgccgg cgaagaagcg cccgcggtgc cgatcaccgg cgacgaaggc     1980

atgtcgatga tcttctcggc gtgctgccgc ccgatcccgg gcgactccat cgttggctac     2040

ctgggcaagg gcgaagggct gcagatccac gtgcaggact gcaagatcgc caagcgcctg     2100

cacagcaagg atccggagca ctggatcgac gtgatgtggg ccaagaagac cacgcgcgcc     2160

ttcgacgtgt cgatcaaggt gatggtgcgc aacgtcaagg gcatcgttgc gcgcgtggct     2220

gccgacctga ccgccgccga cgccaacgtc gcgcacgtgg ccatggagca gcaggacgcc     2280

ggccaccagg aagccaccta tatgcagttt atcatccagg tgcagaaccg cctgcacctg     2340

gccaacgtga tgcgcgggct gcgccgcaac ccggacgtca tccggatatt ccgcgaccgc     2400

aacgacggct ag                                                         2412


<210>  26
<211>  803
<212>  PRT
<213>  C. necator

<400>  26

Met Asn Ala Arg Thr Gly Ala Pro Asn Leu Pro Asp Pro Leu Gly Asp 
1               5                   10                  15      


Asp Val Val Gly Glu Arg Ala Val Ala Pro Ala Leu Ala Pro Gly Lys 
            20                  25                  30          


Ser Arg Gly Ala Ala Leu Gln Asp Glu Leu Ala Ala Met Gln Asp Val 
        35                  40                  45              


Ala Pro Ala Ala Asp Ser Leu Phe Ile Asp Ala Val Leu Ala Gln Ser 
    50                  55                  60                  


Tyr Arg His Phe Phe Gly Pro Thr Ser Gln Pro Ala Val Pro Pro Arg 
65                  70                  75                  80  


Gln Gln Val Ile Ser Ile Thr Arg Leu Met Glu Lys Leu Ala Tyr Leu 
                85                  90                  95      


Lys Ala Pro Asp Leu Ala Arg Val Arg Glu Ala Phe Gln Phe Ser Asp 
            100                 105                 110         


Glu Ala His Leu Gly Gln Tyr Arg Gln Ser Gly Glu Pro Tyr Ile Thr 
        115                 120                 125             


His Pro Val Ala Val Ala Glu Leu Cys Ala Asp Trp Lys Leu Asp Val 
    130                 135                 140                 


Gln Ser Ile Met Ala Ala Leu Leu His Asp Val Met Glu Asp Gln Gly 
145                 150                 155                 160 


Ile Thr Lys Ser Glu Leu Val Glu Lys Phe Gly Pro Lys Val Ala Glu 
                165                 170                 175     


Leu Val Asp Gly Leu Thr Lys Leu Asp Lys Leu Glu Phe Gln Ser Arg 
            180                 185                 190         


Glu Gln Ala Gln Ala Glu Ser Phe Arg Lys Met Leu Leu Ala Met Ala 
        195                 200                 205             


Arg Asp Val Arg Val Ile Leu Val Lys Leu Ala Asp Arg Thr His Asn 
    210                 215                 220                 


Met Arg Thr Leu Asp Phe Val Pro Pro Glu Lys Arg Arg Arg Ile Ala 
225                 230                 235                 240 


Leu Glu Thr Met Glu Ile Tyr Ala Pro Ile Ala His Arg Leu Gly Leu 
                245                 250                 255     


Asn Thr Ile Tyr Arg Glu Leu Gln Glu Leu Ser Phe Lys Val Gly Ser 
            260                 265                 270         


Pro Phe Arg Tyr Ala Thr Leu Glu Lys Ala Val Lys Ala Ala Arg Gly 
        275                 280                 285             


Asn Arg Arg Glu Val Val Lys Arg Ile Leu Glu Ala Ala Gln Lys Gly 
    290                 295                 300                 


Leu Ala Asp Ala Gly Ile Val Ala Glu Leu Ser Gly Arg Glu Lys Thr 
305                 310                 315                 320 


Leu Tyr Ser Ile Tyr Arg Lys Met His Asp Lys Gln Leu Ser Phe Ser 
                325                 330                 335     


Gln Val Leu Asp Val Tyr Gly Phe Arg Val Val Val Glu Thr Gln Met 
            340                 345                 350         


His Cys Tyr Met Ala Met Gly Ala Leu His Gly Leu Tyr Lys Pro Met 
        355                 360                 365             


Pro Gly Lys Phe Lys Asp Tyr Ile Ala Ile Pro Lys Ile Asn Gly Tyr 
    370                 375                 380                 


Gln Ser Leu His Thr Thr Leu Val Gly Pro Phe Gly Thr Pro Val Glu 
385                 390                 395                 400 


Phe Gln Ile Arg Thr Arg Asp Met His Gln Ile Ala Glu Ala Gly Val 
                405                 410                 415     


Ala Ala His Trp Met Tyr Lys His Gln Ala Asp His Ala Asn Asp Ile 
            420                 425                 430         


Gln Gln Gln Ala His Gln Trp Leu Gln Ser Leu Leu Asp Ile Gln Ser 
        435                 440                 445             


Gln Thr Gly Asp Ser Gln Glu Phe Leu Glu His Val Lys Ile Asp Leu 
    450                 455                 460                 


Phe Pro Asp Ala Val Tyr Val Phe Thr Pro Lys Gly His Ile Arg Ala 
465                 470                 475                 480 


Leu Pro Arg Gly Ala Thr Ala Leu Asp Phe Ala Tyr Ala Val His Ser 
                485                 490                 495     


Asp Leu Gly Asn Gln Cys Val Ala Val Lys Ile Asn Asn Glu Met Leu 
            500                 505                 510         


Pro Leu Arg Thr Glu Leu Lys Ser Gly Asp Ile Val Glu Val Val Thr 
        515                 520                 525             


Ala Pro Tyr Ser Lys Pro Asn Pro Ala Trp Leu Ser Phe Val Arg Thr 
    530                 535                 540                 


Gly Lys Ala Arg Ala Ala Ile Arg His Tyr Leu Lys Thr Thr Lys Leu 
545                 550                 555                 560 


Asp Glu Ala Ile Gln Leu Gly Glu Arg Leu Leu Glu Gln Ser Ala Arg 
                565                 570                 575     


Gln Leu Gly Phe Glu Leu Lys Ala Val Pro Gln Ser Val Trp Asp Arg 
            580                 585                 590         


Met Val Gln Trp Thr Gly Asn Lys Gln Arg Glu Asp Ile Phe Ala Asp 
        595                 600                 605             


Leu Ala Leu Gly Arg Arg Val Pro Ala Val Val Ala Lys Arg Met Glu 
    610                 615                 620                 


Ile Leu Leu Gln Glu Leu Ser Gly Asp Val Asp Ser Ala Leu Leu Ala 
625                 630                 635                 640 


Ala Val Gln Thr Phe Ala Gly Glu Glu Ala Pro Ala Val Pro Ile Thr 
                645                 650                 655     


Gly Asp Glu Gly Met Ser Met Ile Phe Ser Ala Cys Cys Arg Pro Ile 
            660                 665                 670         


Pro Gly Asp Ser Ile Val Gly Tyr Leu Gly Lys Gly Glu Gly Leu Gln 
        675                 680                 685             


Ile His Val Gln Asp Cys Lys Ile Ala Lys Arg Leu His Ser Lys Asp 
    690                 695                 700                 


Pro Glu His Trp Ile Asp Val Met Trp Ala Lys Lys Thr Thr Arg Ala 
705                 710                 715                 720 


Phe Asp Val Ser Ile Lys Val Met Val Arg Asn Val Lys Gly Ile Val 
                725                 730                 735     


Ala Arg Val Ala Ala Asp Leu Thr Ala Ala Asp Ala Asn Val Ala His 
            740                 745                 750         


Val Ala Met Glu Gln Gln Asp Ala Gly His Gln Glu Ala Thr Tyr Met 
        755                 760                 765             


Gln Phe Ile Ile Gln Val Gln Asn Arg Leu His Leu Ala Asn Val Met 
    770                 775                 780                 


Arg Gly Leu Arg Arg Asn Pro Asp Val Ile Arg Ile Phe Arg Asp Arg 
785                 790                 795                 800 


Asn Asp Gly 
            


<210>  27
<211>  948
<212>  DNA
<213>  C. necator

<400>  27
atgcgcgacc gaatcctagc cgtctacgac acgctccgcc cttctgaacg ccgcctggcc       60

gactatgtcg cccggcatgg cgccgccgtg atccggctgt cgatgcccga gctggccgag      120

cgcgccggcg tgtcgcagcc caccatcgcg cgcttctgcg cggcgctggg ctacgacggc      180

ttccgcgaat tcaagctgca gttcgcgcag aacgttggcg gcggcacgcc cttcgtgcac      240

caggacgtcg cggccgacga ccgccccgcg gacatcgccg gcaaggtctt cgaccgcacc      300

attgccacgc tgatgagcgt gcgcaatgcg ctgtcggccg accagatcga gcatggcatc      360

cagctgctcg ccggcgcgcg ccgcatcgag ttctacggct gcggcaactc cggcatcgtc      420

gcgctggata tccagcacaa gttcttccgc ctgggcatgc cgacggttgc gtattccgac      480

ccgcacgtgt tcagcatgtc ggccgcgctg ctcgcccgtg gcgacgtggc cgtgctggtc      540

tccaacagcg gccgcacctg ggacatgctg accgctgcca cgctggcgcg cagcagcggc      600

gccagcgtgc tggcaatcac gcacagcggc tcgccgctgg cgcggctggc tgacgtctgc      660

gtgttttccg acgtcgagga agacagcgag gtctacacgc cgatgacctc gcgcatcagc      720

cacctggtgc tgggcgacgt cctggccgcc ggcgtggcgc ttgcgcgcgc cgacaccgtc      780

gccccccgcc tgcagcgcgc caaggcgcat ctgcgcgaac gacgcattgc cggtgcggag      840

ccggcccggc cagtaccgcc ggcacgaaac cgcgccaggc ccgccgcagc cgagccagcc      900

acgcccgcgc tgcccgccac ccgcacgcgt cgccgcaagg ccagttga                   948


<210>  28
<211>  315
<212>  PRT
<213>  C. necator

<400>  28

Met Arg Asp Arg Ile Leu Ala Val Tyr Asp Thr Leu Arg Pro Ser Glu 
1               5                   10                  15      


Arg Arg Leu Ala Asp Tyr Val Ala Arg His Gly Ala Ala Val Ile Arg 
            20                  25                  30          


Leu Ser Met Pro Glu Leu Ala Glu Arg Ala Gly Val Ser Gln Pro Thr 
        35                  40                  45              


Ile Ala Arg Phe Cys Ala Ala Leu Gly Tyr Asp Gly Phe Arg Glu Phe 
    50                  55                  60                  


Lys Leu Gln Phe Ala Gln Asn Val Gly Gly Gly Thr Pro Phe Val His 
65                  70                  75                  80  


Gln Asp Val Ala Ala Asp Asp Arg Pro Ala Asp Ile Ala Gly Lys Val 
                85                  90                  95      


Phe Asp Arg Thr Ile Ala Thr Leu Met Ser Val Arg Asn Ala Leu Ser 
            100                 105                 110         


Ala Asp Gln Ile Glu His Gly Ile Gln Leu Leu Ala Gly Ala Arg Arg 
        115                 120                 125             


Ile Glu Phe Tyr Gly Cys Gly Asn Ser Gly Ile Val Ala Leu Asp Ile 
    130                 135                 140                 


Gln His Lys Phe Phe Arg Leu Gly Met Pro Thr Val Ala Tyr Ser Asp 
145                 150                 155                 160 


Pro His Val Phe Ser Met Ser Ala Ala Leu Leu Ala Arg Gly Asp Val 
                165                 170                 175     


Ala Val Leu Val Ser Asn Ser Gly Arg Thr Trp Asp Met Leu Thr Ala 
            180                 185                 190         


Ala Thr Leu Ala Arg Ser Ser Gly Ala Ser Val Leu Ala Ile Thr His 
        195                 200                 205             


Ser Gly Ser Pro Leu Ala Arg Leu Ala Asp Val Cys Val Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asp Ser Glu Val Tyr Thr Pro Met Thr Ser Arg Ile Ser 
225                 230                 235                 240 


His Leu Val Leu Gly Asp Val Leu Ala Ala Gly Val Ala Leu Ala Arg 
                245                 250                 255     


Ala Asp Thr Val Ala Pro Arg Leu Gln Arg Ala Lys Ala His Leu Arg 
            260                 265                 270         


Glu Arg Arg Ile Ala Gly Ala Glu Pro Ala Arg Pro Val Pro Pro Ala 
        275                 280                 285             


Arg Asn Arg Ala Arg Pro Ala Ala Ala Glu Pro Ala Thr Pro Ala Leu 
    290                 295                 300                 


Pro Ala Thr Arg Thr Arg Arg Arg Lys Ala Ser 
305                 310                 315 


<210>  29
<211>  2229
<212>  DNA
<213>  C. necator

<400>  29
atggtgacgt ccaccgacct gaccggtcgg gtcgcgggca ttccggatgc cgaactggtc       60

gaacgcgcac tggcctacgt gcgcgagcat ggtgccgagg tagcgctgcc caccggcgag      120

accgtgctgt cgcacgcgca gggcatgctg cgcattctcg acggcctgcg cgtcgacgac      180

gccgcgcgtg ccgccgcctg cctgttcggg ctggtggcct tcgtgcccgg taccgaggcc      240

gagatcgcac cgcgctttgg agacgaggtg gcacggctgg tcgacggtgt gcggcagctg      300

ctgcgcatcg gtgccatcgc cggcagccgc cccgaggccg agccggccgc gccgtccaag      360

aacgaagcgc aggcgcgcca cgaacaggtc gaggcgctgc gcaagatgct gctggcgttt      420

gcgcaggaca tccgcgtggt gctggtgcgc ctggcctcgc ggctgcagac cctgcgctgg      480

ctggccgaga ccaagcaggc gccgcagccg ggcgtggcgc gcgaaacgct ggacatctac      540

gcgccgctgg ccaatcgcct tggtatctgg cagatgaagt gggaactgga ggacctggcg      600

ttccgcttcg agcagcccga tacctacaag cgcatcgcca aactgctgga cgagaagcgc      660

atcgagcgcg aaggctatat cggcggcgcc atcgaacggc tgcagtccga gctggcgact      720

gccggcatcc gtgccgaggt cagcgggcgg cccaagcata tctacagcat ctggaagaag      780

atgcgcggca aggagctgga ttttgccgac ctgtacgatg tgcgcgcctt ccgcgtgatc      840

gtcgacgata tcaaggactg ctacacggtg ctgggtatcg tccaccatat ctggcagccg      900

atcccgcgcg agttcgacga ctatatctcg cggcccaagg ccaatggcta caaatcgctg      960

catacggtgg tgatcggcga tgacgggcgc gccttcgagg tgcagatccg cacgcatgag     1020

atgcaccact ttgccgaata cggcgtggcc gcgcactggc gctacaagga agcgggcagc     1080

cgcggctatg ccgggcagtt ctccgccagc gagcgctatg acgagaagat tgcctggctg     1140

cgccagctgc tggcgtggaa ggacgatgcc gaccacagcg tggcgcacga tgaatcgtgg     1200

gagcagatca agcacgccgc gatcgacgac cacatctacg tgctgacgcc gcaggcgcgc     1260

gtggtggcgc tgccgcaggg cgccaccgcg gtggactttg cctactacct gcacagcgat     1320

ctcggccacc gctgccgcgg cgcgcgcgtg gacggcacca tggtgccgct gaacacgccg     1380

ctgaagaacg gccagaccgt ggagatcatc gcggtcaagc agggcggacc gtcgcgcgac     1440

tggctcaacg cggacctggg ctacctggcc agcagccgcg cgcgggccaa ggtgcgggcc     1500

tggttcaatg cgctcgattc gcaggagacc atcgcccagg gccgcgtgct gatcgacaag     1560

accctgcagc gcgaaggcaa gaccgcggtc aagctggaag acctggccac gcggctgggc     1620

ttcaagacgc cggaggacct gtttgcggca gtggccaagg acgagttcag tctgcgccac     1680

gtggagcacg cgctgcgaca cccggagggc gaggtccagg cgccgctgag cgaggaagac     1740

gctgtcacca agaagagccg cgccaccagc gtggcgcgcg gcgccaagag cggcgtgctg     1800

gtggtggggg tggattcgct gatgacgcag atgtcgcgct gctgcaagcc ggcgccgccg     1860

gacgacatcg tcggctttgt cacgcgcggg cgcggggtgt cgatccatcg gcgcagctgc     1920

cacaccttcc agcaactggc cgggcgcgcg ccggagcggg tgatccagac cgagtggggc     1980

cagaagagcc acgccgcggt ctatccggtc gatatccatg tcgaggcgat cgatcgccag     2040

gggctgctgc gcgatatctc cgaagtgctg tcgcgcgaga agatcaatgt caccggcgtc     2100

aagacgctct ccagcaaggg cgttgcgcgc atgcagttca ctgccgaagt gtccgaggct     2160

acgcagctgc agcgcgcgct gcagttgatc gaagacgtcc agggggtgtt gcaggcgaaa     2220

agaaagtga                                                             2229


<210>  30
<211>  742
<212>  PRT
<213>  C. necator

<400>  30

Met Val Thr Ser Thr Asp Leu Thr Gly Arg Val Ala Gly Ile Pro Asp 
1               5                   10                  15      


Ala Glu Leu Val Glu Arg Ala Leu Ala Tyr Val Arg Glu His Gly Ala 
            20                  25                  30          


Glu Val Ala Leu Pro Thr Gly Glu Thr Val Leu Ser His Ala Gln Gly 
        35                  40                  45              


Met Leu Arg Ile Leu Asp Gly Leu Arg Val Asp Asp Ala Ala Arg Ala 
    50                  55                  60                  


Ala Ala Cys Leu Phe Gly Leu Val Ala Phe Val Pro Gly Thr Glu Ala 
65                  70                  75                  80  


Glu Ile Ala Pro Arg Phe Gly Asp Glu Val Ala Arg Leu Val Asp Gly 
                85                  90                  95      


Val Arg Gln Leu Leu Arg Ile Gly Ala Ile Ala Gly Ser Arg Pro Glu 
            100                 105                 110         


Ala Glu Pro Ala Ala Pro Ser Lys Asn Glu Ala Gln Ala Arg His Glu 
        115                 120                 125             


Gln Val Glu Ala Leu Arg Lys Met Leu Leu Ala Phe Ala Gln Asp Ile 
    130                 135                 140                 


Arg Val Val Leu Val Arg Leu Ala Ser Arg Leu Gln Thr Leu Arg Trp 
145                 150                 155                 160 


Leu Ala Glu Thr Lys Gln Ala Pro Gln Pro Gly Val Ala Arg Glu Thr 
                165                 170                 175     


Leu Asp Ile Tyr Ala Pro Leu Ala Asn Arg Leu Gly Ile Trp Gln Met 
            180                 185                 190         


Lys Trp Glu Leu Glu Asp Leu Ala Phe Arg Phe Glu Gln Pro Asp Thr 
        195                 200                 205             


Tyr Lys Arg Ile Ala Lys Leu Leu Asp Glu Lys Arg Ile Glu Arg Glu 
    210                 215                 220                 


Gly Tyr Ile Gly Gly Ala Ile Glu Arg Leu Gln Ser Glu Leu Ala Thr 
225                 230                 235                 240 


Ala Gly Ile Arg Ala Glu Val Ser Gly Arg Pro Lys His Ile Tyr Ser 
                245                 250                 255     


Ile Trp Lys Lys Met Arg Gly Lys Glu Leu Asp Phe Ala Asp Leu Tyr 
            260                 265                 270         


Asp Val Arg Ala Phe Arg Val Ile Val Asp Asp Ile Lys Asp Cys Tyr 
        275                 280                 285             


Thr Val Leu Gly Ile Val His His Ile Trp Gln Pro Ile Pro Arg Glu 
    290                 295                 300                 


Phe Asp Asp Tyr Ile Ser Arg Pro Lys Ala Asn Gly Tyr Lys Ser Leu 
305                 310                 315                 320 


His Thr Val Val Ile Gly Asp Asp Gly Arg Ala Phe Glu Val Gln Ile 
                325                 330                 335     


Arg Thr His Glu Met His His Phe Ala Glu Tyr Gly Val Ala Ala His 
            340                 345                 350         


Trp Arg Tyr Lys Glu Ala Gly Ser Arg Gly Tyr Ala Gly Gln Phe Ser 
        355                 360                 365             


Ala Ser Glu Arg Tyr Asp Glu Lys Ile Ala Trp Leu Arg Gln Leu Leu 
    370                 375                 380                 


Ala Trp Lys Asp Asp Ala Asp His Ser Val Ala His Asp Glu Ser Trp 
385                 390                 395                 400 


Glu Gln Ile Lys His Ala Ala Ile Asp Asp His Ile Tyr Val Leu Thr 
                405                 410                 415     


Pro Gln Ala Arg Val Val Ala Leu Pro Gln Gly Ala Thr Ala Val Asp 
            420                 425                 430         


Phe Ala Tyr Tyr Leu His Ser Asp Leu Gly His Arg Cys Arg Gly Ala 
        435                 440                 445             


Arg Val Asp Gly Thr Met Val Pro Leu Asn Thr Pro Leu Lys Asn Gly 
    450                 455                 460                 


Gln Thr Val Glu Ile Ile Ala Val Lys Gln Gly Gly Pro Ser Arg Asp 
465                 470                 475                 480 


Trp Leu Asn Ala Asp Leu Gly Tyr Leu Ala Ser Ser Arg Ala Arg Ala 
                485                 490                 495     


Lys Val Arg Ala Trp Phe Asn Ala Leu Asp Ser Gln Glu Thr Ile Ala 
            500                 505                 510         


Gln Gly Arg Val Leu Ile Asp Lys Thr Leu Gln Arg Glu Gly Lys Thr 
        515                 520                 525             


Ala Val Lys Leu Glu Asp Leu Ala Thr Arg Leu Gly Phe Lys Thr Pro 
    530                 535                 540                 


Glu Asp Leu Phe Ala Ala Val Ala Lys Asp Glu Phe Ser Leu Arg His 
545                 550                 555                 560 


Val Glu His Ala Leu Arg His Pro Glu Gly Glu Val Gln Ala Pro Leu 
                565                 570                 575     


Ser Glu Glu Asp Ala Val Thr Lys Lys Ser Arg Ala Thr Ser Val Ala 
            580                 585                 590         


Arg Gly Ala Lys Ser Gly Val Leu Val Val Gly Val Asp Ser Leu Met 
        595                 600                 605             


Thr Gln Met Ser Arg Cys Cys Lys Pro Ala Pro Pro Asp Asp Ile Val 
    610                 615                 620                 


Gly Phe Val Thr Arg Gly Arg Gly Val Ser Ile His Arg Arg Ser Cys 
625                 630                 635                 640 


His Thr Phe Gln Gln Leu Ala Gly Arg Ala Pro Glu Arg Val Ile Gln 
                645                 650                 655     


Thr Glu Trp Gly Gln Lys Ser His Ala Ala Val Tyr Pro Val Asp Ile 
            660                 665                 670         


His Val Glu Ala Ile Asp Arg Gln Gly Leu Leu Arg Asp Ile Ser Glu 
        675                 680                 685             


Val Leu Ser Arg Glu Lys Ile Asn Val Thr Gly Val Lys Thr Leu Ser 
    690                 695                 700                 


Ser Lys Gly Val Ala Arg Met Gln Phe Thr Ala Glu Val Ser Glu Ala 
705                 710                 715                 720 


Thr Gln Leu Gln Arg Ala Leu Gln Leu Ile Glu Asp Val Gln Gly Val 
                725                 730                 735     


Leu Gln Ala Lys Arg Lys 
            740         


<210>  31
<211>  4857
<212>  DNA
<213>  C. necator

<400>  31
atgccgcagg agaacgaaga caaggtcgcg cacctgctgg acgaactggc cagcttcgcg       60

cgcgagcggc tgccggcggc gatgttcgcc gtggtcgagc ccttcctgct gcactactac      120

gatcaggccg acgccgagga cttgctccag cgcgacgtcg acgatctcta cggcgccgtg      180

atggcgcact ggcagaccgc acagaaattc acccccggca atgcgcgcat ccgcgtctac      240

aatcccaacc tggaagagca cggctggcac tcggaccaca ccgtggtcga gatcgtcaat      300

gacgacatgc ccttcctggt cgactcggtg acgatggaga tcaaccggca gggactggcg      360

ctgcactcgg ccatccatcc cgtgttccgg gtctggcgcg acgcgcgcgg cggcatcgag      420

cggatcgccc cgggcggcgc cggcgaggcc ggggacagct cgcgcctgga atcctttatc      480

catttcgaga tcgaccgcag cggcgaggcc gcgcggctgg aggcgctgcg cagcggcatt      540

gcgcaggtgc tggtcgacgt gcgcgcggcg gtggaagact ggtcgaagat gtgcggcatc      600

acccaggcca ccatcgccgc catggcgcag gcgcccgacg cggccgcgcc ggagagcgtc      660

gaggcgcgcg ccttcctgga ctggatgatg gatgaccact tctccttcct cggccagcgt      720

gactaccagc tggtgtcgca ggacggccgc tacttcctgc gcggcgtgcc gggctcgggc      780

gcgggcatcc tgcgcgaaag cctgcgcgag cctgatgccg aagatctcac gctgctgccc      840

gccgcggcca ccgcgatcat cgaaggggcc tcgccgatct tcctgaccaa ggccaattcg      900

cgcgccaccg tgcaccgccc gggctatctc gactatgtcg gcgtcaagct gctcgatgaa      960

aaggggcagc tgttcggcga gcggcgcttt gtcggcctgt acacctcgac tgcctatacg     1020

gcgccgattg cggaaattcc gctggtgcgg ctcaagtgcg ccaatatcct ggcgcgcgcg     1080

ggcttcctgg ccaaggggca cctttacaag tcgctggtga ccatccttga gcaatatccg     1140

cgcgatgaac tgttccaggc caccgaggat gaactgttcg acatcaccac cggcatcctg     1200

cggctgcagg aacaccagcg cacccggctc tttgtacggc gcgaccgctt cgaccgcttt     1260

gtctcgtgcc tggtgttcgt gccgcgcgac aagtacaaca ccgacctgcg ccagaagatc     1320

cagaggctgc tgaccgcggc cttccacggc accagctgcg agttcacgcc gctgctgtcc     1380

gagtcgccgc tggcgcgcat ccagctgacc gtgcgcggcg agcccggcac catgccgcat     1440

gttgatacgc gtgagctgga ggcgcgcatc gtgcacgcca gccgccgctg gcaggacgat     1500

ctcgccgaag ccctgcatga aagccacggc gaagagcaag gcaaccggct gctgcagcgc     1560

tacggcggct cgttccccgc cggctaccgt gaggactacc cggcccgcac cgcggtgcgc     1620

gatatcgagc tgatggagca cgcgctgcgc ggcaacggca tggcgatgaa cctgtaccgg     1680

ccgatcgagg ccgcgccggg ggtgttccgc ttcaaggtgt accgtgccgg cgagccgatc     1740

gcgctgtcgc acagcctgcc catgctggaa cacctgggcg tgcgcgtgga tgaagagcgc     1800

ccctacctga tcgaacccga cagcggcgcg ccggtatggg tgcacgactt cgggctggag     1860

attgccgaca gcggcggcgc ggcggaattc gacatcgcgc gcgtcaaggc cttgttcgag     1920

gatgcgttcg cgcgcgcctg gcacggcgag atcgagaacg acgacttcaa ccgcctggtg     1980

ctgcgcgccg agctggccgc acgcgacgtc accatcctgc gcgcctatgc ccgctacctg     2040

cgccaggtag gctcgacctt cagcgacgcc tatatcgagc gcgcgctgac cggcaacgcg     2100

gccattgccg ccatgctggt cggcctgttc gtggcgcgct tcgacacctt cagcgaggtc     2160

gccaccgaca ccgcccgcca ggcgcgctgc gacaagctgc tggccgatat cggcgcggcg     2220

ctggacaagg tgcccaacct ggacgaggac cgcatcctgc ggcttttcct gggcgtgatc     2280

aacgccaccg tgcgcaccaa ctatttccac cgcggcgagg aaggccagcc gcgcccatat     2340

gtgtcgttca agttcaatcc cgcgctggtc cccggcctgc ccgagccgcg cccgatgttc     2400

gagatctggg tctactcgcc gcgcgttgag ggcgtgcacc tgcgcggcgg gcgcgtggcc     2460

cgcggcggac tgcgctggtc agaccggcgc gaggacttcc gcactgaagt gctgggcctg     2520

atgaaggcgc agatggtcaa gaacacggtg atcgtgccgg tgggctccaa gggcggcttc     2580

gtggtcaagc gcccgccccc gcccaccgac cgcgatgcgt tcctgcagga gggcatcgcc     2640

tgctaccaga ccttcctgcg cgggctgctg gacctcaccg acaacctcgt cggcggccag     2700

ctggtgccgc cacccgaggt ggtgcgccac gacgacaacg acccctacct ggtggtcgcc     2760

gccgacaagg gcaccgcgac gttctccgac ttcgccaacg cgatctcggc cgaatacggc     2820

ttctggctgg gcgatgcctt tgcgtccggg ggctcggtcg gctatgacca caagaagatg     2880

ggcattaccg cgcgcggtgc gtgggaatcg gtcaagcggc atttccgcga gatgggtgtc     2940

gatatccaga ccacggactt caccgtggcc ggcatcggcg acatgtcggg cgatgtgttc     3000

ggcaacggca tgctgctgtc gccgcatatc cggctggtgg cggctttcga ccaccggcat     3060

atcttcctcg atcccgaccc ggacacgaca aggagcctgc aggaacgcac gcggctgttc     3120

ggcctgcccc gctcaagctg ggccgactac gacgccacgc tgatttccgc cggcggcggc     3180

atctatccgc gcagcgccaa gaccatcgcg ctgtcgccgc aggtgcaggc ggtgctgggg     3240

gtcacggcag ccacgctgtc gccggccgag ctgatccacg ccatcctgat ggcgccggtc     3300

gacctgctct acaacggcgg catcggcact tacgtcaagt ccagccagga aacccacctg     3360

caggccggcg accgcaccaa cgacgcggtg cgtgtcaacg gcaatgacct gcgctgcaag     3420

gtggtcggcg aaggcggcaa cctcggcttc acccagctgg gccgcatcga gttcgcgcgc     3480

aagggcgggc gcatcaacac cgacgccatc gacaactcgg ccggggtgga ctgctcggac     3540

cacgaggtca atatcaagat cctgctcggg ctggtggttg ccgacggcga aatgaccgag     3600

aagcagcgca acaagctgct ggccgagatg accgacgagg tcggcctgct ggtgctgcag     3660

gacaactact accagaccca ggcactgtcc gtggccgggc gcagcagccc cgcgctgctc     3720

gacggcgagg cgcgcctggt gcgctggctg gagcgcgccg gacggctcaa ccggccgctg     3780

gagttcctgc cttcggagga agaaatcgcc gagcgcaagc tggccgatga aggcctggca     3840

tcgcccgagc gtgccgtgct gcttgcctac agcaagatgt ggctgtacga cgaactgctg     3900

gcctccgacg tgccggaaga cacgctggtc gccggactgc tgtcggacta tttcccggtg     3960

ccgctgcgcc agcgttacgc cgacgcgatg cagcgccacc cgctgcggcg cgagatcctg     4020

tcgacacacc tgaccaatat gctggtcaac cgtatcggcg ccaccttcgt gcaccggatc     4080

atggaagaga ccgacgcacg cccggccgat atcgtgcgcg cctgcctgat cgcacgcgat     4140

gtcttcggcc tgaccaccct gtggcaggag atcgatgcgc tggacaaccg tgtggccgat     4200

gccgagcagg cgcgcatgtt cggggccgtg gcgctgctgc tggagcgcgc gtgcctgtgg     4260

ttcatccgct atctgcgcag cggcagcaag gccgccgagg acctggcgcg ctttgcccag     4320

gccgcgcaat ggctggcccc gcaactgccg cggctgctgc cgccggccga tgcgacggca     4380

ctgtcagagc gcgcccgggc cttgacggat gcaggggtcg acgaagcgct ggctgtgcgc     4440

gtggccggca gcgagatctc cgccgccgcg ctcgatatcg ccgaagtggc cacggcgtgc     4500

aaacgcagcc tggacctggt ggcgggggtt tatttcgcgc tggacagcca cctgagcttc     4560

agctggctgc gcgagcgcgc gctggcgctg ccatcggaca cgcactggga cctgctggca     4620

cgcaccacca cgctggaaga cctggggcgg ctcaagcgcg cactgaccgt cagcgtgctg     4680

tcacaggagg gtgaactgga tacgcccgac gccatgatcg atgcctggcg ctccagccgt     4740

catggcgcgc tggaacgctt tacgcgcatg ctggccgacc agcgcgcctc gggggctgcg     4800

gggctgtcga tgctgtcggt cgcggtgcgc gagatcggca tgctggaacg cgcatag        4857


<210>  32
<211>  1618
<212>  PRT
<213>  C. necator

<400>  32

Met Pro Gln Glu Asn Glu Asp Lys Val Ala His Leu Leu Asp Glu Leu 
1               5                   10                  15      


Ala Ser Phe Ala Arg Glu Arg Leu Pro Ala Ala Met Phe Ala Val Val 
            20                  25                  30          


Glu Pro Phe Leu Leu His Tyr Tyr Asp Gln Ala Asp Ala Glu Asp Leu 
        35                  40                  45              


Leu Gln Arg Asp Val Asp Asp Leu Tyr Gly Ala Val Met Ala His Trp 
    50                  55                  60                  


Gln Thr Ala Gln Lys Phe Thr Pro Gly Asn Ala Arg Ile Arg Val Tyr 
65                  70                  75                  80  


Asn Pro Asn Leu Glu Glu His Gly Trp His Ser Asp His Thr Val Val 
                85                  90                  95      


Glu Ile Val Asn Asp Asp Met Pro Phe Leu Val Asp Ser Val Thr Met 
            100                 105                 110         


Glu Ile Asn Arg Gln Gly Leu Ala Leu His Ser Ala Ile His Pro Val 
        115                 120                 125             


Phe Arg Val Trp Arg Asp Ala Arg Gly Gly Ile Glu Arg Ile Ala Pro 
    130                 135                 140                 


Gly Gly Ala Gly Glu Ala Gly Asp Ser Ser Arg Leu Glu Ser Phe Ile 
145                 150                 155                 160 


His Phe Glu Ile Asp Arg Ser Gly Glu Ala Ala Arg Leu Glu Ala Leu 
                165                 170                 175     


Arg Ser Gly Ile Ala Gln Val Leu Val Asp Val Arg Ala Ala Val Glu 
            180                 185                 190         


Asp Trp Ser Lys Met Cys Gly Ile Thr Gln Ala Thr Ile Ala Ala Met 
        195                 200                 205             


Ala Gln Ala Pro Asp Ala Ala Ala Pro Glu Ser Val Glu Ala Arg Ala 
    210                 215                 220                 


Phe Leu Asp Trp Met Met Asp Asp His Phe Ser Phe Leu Gly Gln Arg 
225                 230                 235                 240 


Asp Tyr Gln Leu Val Ser Gln Asp Gly Arg Tyr Phe Leu Arg Gly Val 
                245                 250                 255     


Pro Gly Ser Gly Ala Gly Ile Leu Arg Glu Ser Leu Arg Glu Pro Asp 
            260                 265                 270         


Ala Glu Asp Leu Thr Leu Leu Pro Ala Ala Ala Thr Ala Ile Ile Glu 
        275                 280                 285             


Gly Ala Ser Pro Ile Phe Leu Thr Lys Ala Asn Ser Arg Ala Thr Val 
    290                 295                 300                 


His Arg Pro Gly Tyr Leu Asp Tyr Val Gly Val Lys Leu Leu Asp Glu 
305                 310                 315                 320 


Lys Gly Gln Leu Phe Gly Glu Arg Arg Phe Val Gly Leu Tyr Thr Ser 
                325                 330                 335     


Thr Ala Tyr Thr Ala Pro Ile Ala Glu Ile Pro Leu Val Arg Leu Lys 
            340                 345                 350         


Cys Ala Asn Ile Leu Ala Arg Ala Gly Phe Leu Ala Lys Gly His Leu 
        355                 360                 365             


Tyr Lys Ser Leu Val Thr Ile Leu Glu Gln Tyr Pro Arg Asp Glu Leu 
    370                 375                 380                 


Phe Gln Ala Thr Glu Asp Glu Leu Phe Asp Ile Thr Thr Gly Ile Leu 
385                 390                 395                 400 


Arg Leu Gln Glu His Gln Arg Thr Arg Leu Phe Val Arg Arg Asp Arg 
                405                 410                 415     


Phe Asp Arg Phe Val Ser Cys Leu Val Phe Val Pro Arg Asp Lys Tyr 
            420                 425                 430         


Asn Thr Asp Leu Arg Gln Lys Ile Gln Arg Leu Leu Thr Ala Ala Phe 
        435                 440                 445             


His Gly Thr Ser Cys Glu Phe Thr Pro Leu Leu Ser Glu Ser Pro Leu 
    450                 455                 460                 


Ala Arg Ile Gln Leu Thr Val Arg Gly Glu Pro Gly Thr Met Pro His 
465                 470                 475                 480 


Val Asp Thr Arg Glu Leu Glu Ala Arg Ile Val His Ala Ser Arg Arg 
                485                 490                 495     


Trp Gln Asp Asp Leu Ala Glu Ala Leu His Glu Ser His Gly Glu Glu 
            500                 505                 510         


Gln Gly Asn Arg Leu Leu Gln Arg Tyr Gly Gly Ser Phe Pro Ala Gly 
        515                 520                 525             


Tyr Arg Glu Asp Tyr Pro Ala Arg Thr Ala Val Arg Asp Ile Glu Leu 
    530                 535                 540                 


Met Glu His Ala Leu Arg Gly Asn Gly Met Ala Met Asn Leu Tyr Arg 
545                 550                 555                 560 


Pro Ile Glu Ala Ala Pro Gly Val Phe Arg Phe Lys Val Tyr Arg Ala 
                565                 570                 575     


Gly Glu Pro Ile Ala Leu Ser His Ser Leu Pro Met Leu Glu His Leu 
            580                 585                 590         


Gly Val Arg Val Asp Glu Glu Arg Pro Tyr Leu Ile Glu Pro Asp Ser 
        595                 600                 605             


Gly Ala Pro Val Trp Val His Asp Phe Gly Leu Glu Ile Ala Asp Ser 
    610                 615                 620                 


Gly Gly Ala Ala Glu Phe Asp Ile Ala Arg Val Lys Ala Leu Phe Glu 
625                 630                 635                 640 


Asp Ala Phe Ala Arg Ala Trp His Gly Glu Ile Glu Asn Asp Asp Phe 
                645                 650                 655     


Asn Arg Leu Val Leu Arg Ala Glu Leu Ala Ala Arg Asp Val Thr Ile 
            660                 665                 670         


Leu Arg Ala Tyr Ala Arg Tyr Leu Arg Gln Val Gly Ser Thr Phe Ser 
        675                 680                 685             


Asp Ala Tyr Ile Glu Arg Ala Leu Thr Gly Asn Ala Ala Ile Ala Ala 
    690                 695                 700                 


Met Leu Val Gly Leu Phe Val Ala Arg Phe Asp Thr Phe Ser Glu Val 
705                 710                 715                 720 


Ala Thr Asp Thr Ala Arg Gln Ala Arg Cys Asp Lys Leu Leu Ala Asp 
                725                 730                 735     


Ile Gly Ala Ala Leu Asp Lys Val Pro Asn Leu Asp Glu Asp Arg Ile 
            740                 745                 750         


Leu Arg Leu Phe Leu Gly Val Ile Asn Ala Thr Val Arg Thr Asn Tyr 
        755                 760                 765             


Phe His Arg Gly Glu Glu Gly Gln Pro Arg Pro Tyr Val Ser Phe Lys 
    770                 775                 780                 


Phe Asn Pro Ala Leu Val Pro Gly Leu Pro Glu Pro Arg Pro Met Phe 
785                 790                 795                 800 


Glu Ile Trp Val Tyr Ser Pro Arg Val Glu Gly Val His Leu Arg Gly 
                805                 810                 815     


Gly Arg Val Ala Arg Gly Gly Leu Arg Trp Ser Asp Arg Arg Glu Asp 
            820                 825                 830         


Phe Arg Thr Glu Val Leu Gly Leu Met Lys Ala Gln Met Val Lys Asn 
        835                 840                 845             


Thr Val Ile Val Pro Val Gly Ser Lys Gly Gly Phe Val Val Lys Arg 
    850                 855                 860                 


Pro Pro Pro Pro Thr Asp Arg Asp Ala Phe Leu Gln Glu Gly Ile Ala 
865                 870                 875                 880 


Cys Tyr Gln Thr Phe Leu Arg Gly Leu Leu Asp Leu Thr Asp Asn Leu 
                885                 890                 895     


Val Gly Gly Gln Leu Val Pro Pro Pro Glu Val Val Arg His Asp Asp 
            900                 905                 910         


Asn Asp Pro Tyr Leu Val Val Ala Ala Asp Lys Gly Thr Ala Thr Phe 
        915                 920                 925             


Ser Asp Phe Ala Asn Ala Ile Ser Ala Glu Tyr Gly Phe Trp Leu Gly 
    930                 935                 940                 


Asp Ala Phe Ala Ser Gly Gly Ser Val Gly Tyr Asp His Lys Lys Met 
945                 950                 955                 960 


Gly Ile Thr Ala Arg Gly Ala Trp Glu Ser Val Lys Arg His Phe Arg 
                965                 970                 975     


Glu Met Gly Val Asp Ile Gln Thr Thr Asp Phe Thr Val Ala Gly Ile 
            980                 985                 990         


Gly Asp Met Ser Gly Asp Val Phe  Gly Asn Gly Met Leu  Leu Ser Pro 
        995                 1000                 1005             


His Ile  Arg Leu Val Ala Ala  Phe Asp His Arg His  Ile Phe Leu 
    1010                 1015                 1020             


Asp Pro  Asp Pro Asp Thr Thr  Arg Ser Leu Gln Glu  Arg Thr Arg 
    1025                 1030                 1035             


Leu Phe  Gly Leu Pro Arg Ser  Ser Trp Ala Asp Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Leu Ile  Ser Ala Gly Gly Gly  Ile Tyr Pro Arg Ser  Ala Lys Thr 
    1055                 1060                 1065             


Ile Ala  Leu Ser Pro Gln Val  Gln Ala Val Leu Gly  Val Thr Ala 
    1070                 1075                 1080             


Ala Thr  Leu Ser Pro Ala Glu  Leu Ile His Ala Ile  Leu Met Ala 
    1085                 1090                 1095             


Pro Val  Asp Leu Leu Tyr Asn  Gly Gly Ile Gly Thr  Tyr Val Lys 
    1100                 1105                 1110             


Ser Ser  Gln Glu Thr His Leu  Gln Ala Gly Asp Arg  Thr Asn Asp 
    1115                 1120                 1125             


Ala Val  Arg Val Asn Gly Asn  Asp Leu Arg Cys Lys  Val Val Gly 
    1130                 1135                 1140             


Glu Gly  Gly Asn Leu Gly Phe  Thr Gln Leu Gly Arg  Ile Glu Phe 
    1145                 1150                 1155             


Ala Arg  Lys Gly Gly Arg Ile  Asn Thr Asp Ala Ile  Asp Asn Ser 
    1160                 1165                 1170             


Ala Gly  Val Asp Cys Ser Asp  His Glu Val Asn Ile  Lys Ile Leu 
    1175                 1180                 1185             


Leu Gly  Leu Val Val Ala Asp  Gly Glu Met Thr Glu  Lys Gln Arg 
    1190                 1195                 1200             


Asn Lys  Leu Leu Ala Glu Met  Thr Asp Glu Val Gly  Leu Leu Val 
    1205                 1210                 1215             


Leu Gln  Asp Asn Tyr Tyr Gln  Thr Gln Ala Leu Ser  Val Ala Gly 
    1220                 1225                 1230             


Arg Ser  Ser Pro Ala Leu Leu  Asp Gly Glu Ala Arg  Leu Val Arg 
    1235                 1240                 1245             


Trp Leu  Glu Arg Ala Gly Arg  Leu Asn Arg Pro Leu  Glu Phe Leu 
    1250                 1255                 1260             


Pro Ser  Glu Glu Glu Ile Ala  Glu Arg Lys Leu Ala  Asp Glu Gly 
    1265                 1270                 1275             


Leu Ala  Ser Pro Glu Arg Ala  Val Leu Leu Ala Tyr  Ser Lys Met 
    1280                 1285                 1290             


Trp Leu  Tyr Asp Glu Leu Leu  Ala Ser Asp Val Pro  Glu Asp Thr 
    1295                 1300                 1305             


Leu Val  Ala Gly Leu Leu Ser  Asp Tyr Phe Pro Val  Pro Leu Arg 
    1310                 1315                 1320             


Gln Arg  Tyr Ala Asp Ala Met  Gln Arg His Pro Leu  Arg Arg Glu 
    1325                 1330                 1335             


Ile Leu  Ser Thr His Leu Thr  Asn Met Leu Val Asn  Arg Ile Gly 
    1340                 1345                 1350             


Ala Thr  Phe Val His Arg Ile  Met Glu Glu Thr Asp  Ala Arg Pro 
    1355                 1360                 1365             


Ala Asp  Ile Val Arg Ala Cys  Leu Ile Ala Arg Asp  Val Phe Gly 
    1370                 1375                 1380             


Leu Thr  Thr Leu Trp Gln Glu  Ile Asp Ala Leu Asp  Asn Arg Val 
    1385                 1390                 1395             


Ala Asp  Ala Glu Gln Ala Arg  Met Phe Gly Ala Val  Ala Leu Leu 
    1400                 1405                 1410             


Leu Glu  Arg Ala Cys Leu Trp  Phe Ile Arg Tyr Leu  Arg Ser Gly 
    1415                 1420                 1425             


Ser Lys  Ala Ala Glu Asp Leu  Ala Arg Phe Ala Gln  Ala Ala Gln 
    1430                 1435                 1440             


Trp Leu  Ala Pro Gln Leu Pro  Arg Leu Leu Pro Pro  Ala Asp Ala 
    1445                 1450                 1455             


Thr Ala  Leu Ser Glu Arg Ala  Arg Ala Leu Thr Asp  Ala Gly Val 
    1460                 1465                 1470             


Asp Glu  Ala Leu Ala Val Arg  Val Ala Gly Ser Glu  Ile Ser Ala 
    1475                 1480                 1485             


Ala Ala  Leu Asp Ile Ala Glu  Val Ala Thr Ala Cys  Lys Arg Ser 
    1490                 1495                 1500             


Leu Asp  Leu Val Ala Gly Val  Tyr Phe Ala Leu Asp  Ser His Leu 
    1505                 1510                 1515             


Ser Phe  Ser Trp Leu Arg Glu  Arg Ala Leu Ala Leu  Pro Ser Asp 
    1520                 1525                 1530             


Thr His  Trp Asp Leu Leu Ala  Arg Thr Thr Thr Leu  Glu Asp Leu 
    1535                 1540                 1545             


Gly Arg  Leu Lys Arg Ala Leu  Thr Val Ser Val Leu  Ser Gln Glu 
    1550                 1555                 1560             


Gly Glu  Leu Asp Thr Pro Asp  Ala Met Ile Asp Ala  Trp Arg Ser 
    1565                 1570                 1575             


Ser Arg  His Gly Ala Leu Glu  Arg Phe Thr Arg Met  Leu Ala Asp 
    1580                 1585                 1590             


Gln Arg  Ala Ser Gly Ala Ala  Gly Leu Ser Met Leu  Ser Val Ala 
    1595                 1600                 1605             


Val Arg  Glu Ile Gly Met Leu  Glu Arg Ala 
    1610                 1615             


<210>  33
<211>  633
<212>  DNA
<213>  C. necator

<400>  33
atgaccgcaa cgccaaaccc cacgccccac cgcggcgaga ccgtgttcat cgtcgacgac       60

gatgaagcca tgcgcgactc gctgacctgg ctgctggagg gcaatggcta ccaggtgcgc      120

agcttcacca gcgccgagca gttcctcgcc gcctacgatg ccagccaggt gtcgtgcctg      180

atcctcgacg tgcgcatgcc cggcatgagc ggcccggaac tgcaggagcg catgctggcc      240

gagcagatcg acattcccat cgtctttatc accggccacg gcgacgtgcc gatggcggta      300

tcgacgatga agcgcggcgc catcgacttc atcgaaaagc ccttcgatga gtccgagctg      360

cgcgcactgg tcgagcgcat gctgaccaag gcccgcaccg accattccgc cgcacgcgag      420

cagcgcgccg ccaaggacct gctgggcaag ctgaccacgc gcgagcagca ggtgctcgag      480

cgcatcgttg ccggccgcct gaacaagcag atcgccgacg acctgggcat ttccatcaag      540

accgtggagg cgcaccgcgc caacatcatg gaaaagctca acgtcaacac cgtcgccgac      600

ctgctgcgcc tggcgctgtc acgcaacagc tga                                   633


<210>  34
<211>  210
<212>  PRT
<213>  C. necator

<400>  34

Met Thr Ala Thr Pro Asn Pro Thr Pro His Arg Gly Glu Thr Val Phe 
1               5                   10                  15      


Ile Val Asp Asp Asp Glu Ala Met Arg Asp Ser Leu Thr Trp Leu Leu 
            20                  25                  30          


Glu Gly Asn Gly Tyr Gln Val Arg Ser Phe Thr Ser Ala Glu Gln Phe 
        35                  40                  45              


Leu Ala Ala Tyr Asp Ala Ser Gln Val Ser Cys Leu Ile Leu Asp Val 
    50                  55                  60                  


Arg Met Pro Gly Met Ser Gly Pro Glu Leu Gln Glu Arg Met Leu Ala 
65                  70                  75                  80  


Glu Gln Ile Asp Ile Pro Ile Val Phe Ile Thr Gly His Gly Asp Val 
                85                  90                  95      


Pro Met Ala Val Ser Thr Met Lys Arg Gly Ala Ile Asp Phe Ile Glu 
            100                 105                 110         


Lys Pro Phe Asp Glu Ser Glu Leu Arg Ala Leu Val Glu Arg Met Leu 
        115                 120                 125             


Thr Lys Ala Arg Thr Asp His Ser Ala Ala Arg Glu Gln Arg Ala Ala 
    130                 135                 140                 


Lys Asp Leu Leu Gly Lys Leu Thr Thr Arg Glu Gln Gln Val Leu Glu 
145                 150                 155                 160 


Arg Ile Val Ala Gly Arg Leu Asn Lys Gln Ile Ala Asp Asp Leu Gly 
                165                 170                 175     


Ile Ser Ile Lys Thr Val Glu Ala His Arg Ala Asn Ile Met Glu Lys 
            180                 185                 190         


Leu Asn Val Asn Thr Val Ala Asp Leu Leu Arg Leu Ala Leu Ser Arg 
        195                 200                 205             


Asn Ser 
    210 


<210>  35
<211>  2586
<212>  DNA
<213>  C. necator

<400>  35
atgccgtttt tcgaccgact cctttccagc ctgcgtgcag ccatgcttcc tcccgacgcg       60

tcggggtcag ccaaggcggc cggaggcgat cccgcgcacg ccccttcgcc ggctgccgga      120

ctggggccga tcgaggcgct gggccccgac gacggcgccc ccgtggccgc accgcgcggg      180

ctgtggtggc tgcgctggcg caacctggtg gccaccagct ggttcatgtt catcccgctg      240

gttgccatcg tgctgttcac ggtggccatg ggcgtgatcc tgtggtccct gcacgagacc      300

gagcgccagc agcagcgcga cgccctgtac cgcgacgccg cctgggcgca gcagcgcgtg      360

cgcctgtccc tgctgagcaa ccaggaccag ctggcctcgc tggcgcgcga catcgccgcc      420

gcgcagcttg agcaaggcgc ctaccgcacc gcggcgcagg aaatcctgcg cgaaaacccc      480

gagatcgttt tcatcaactg gctcgatgcc accaagcgcg gccgctggtc gttgccatcg      540

acctcggaat tcgccagccg cctgcgcgag aaccaggacc agccgctcga accggaagtg      600

ctcgacacct tcgacgccgc gcgcgagacc cagcgagtgg tctattcgcg cccgctggtc      660

aacgagcgcg gcgacagctt catgctgatg gaagtgccga tcgtgcgcga caacgagttc      720

ctcggcacgc tcggcgcgct gtactcgatc aacggcatcc tgacgcacct gctgccgcct      780

gagctgaccg agcgctaccg cttctcgctg atcgacaaga acaaccagac ccgcgccagc      840

acctcgttgc ggccggtgcc gggcaacgcg ctgtcgtacg aggtgctgct ggatccgccg      900

ggtcactccc tgtcgctgcg cgccgatgcc tacccgccgg cgtcgaacct gcccaacaac      960

atgctgctgt ggctggtggt ggggctgtcg tgcttcctgc tgtggagcct gtggagcatg     1020

tggcgccaca ccagccgccg ctccgaggcg cagcgcgcgc tgctggccga gacctcgttc     1080

cggcgcgcga tggaaaactc gatgctgatc ggcctgcgcg cgctcgacct gaacggccgc     1140

atcacctatg tcaacccggc cttctgccgc atgactggct ggcaggagaa cgacctggtc     1200

gggcgcctgc cgcccttccc ctactggccg cccaacgacc agcaggagat gcagaagcag     1260

atcgacctga cgctgcaggg caagtcgccc gccggcggct acgagatgcg cgtgatgcgc     1320

cgcgacggca gcagcttcta cgcgcgcatg tacgtgtcgc cgctggtgga cagccgcggc     1380

cgccatactg gctggatgag ctcgatgacg gacatcaccg agcccaagcg cgcgcgcgag     1440

gaactggccg cggcgcatga ccgcttcacc acggtgctgg aaagcctgga tgccgcggtg     1500

tcggtgctgg ccaccgacaa ggcggagctg ctctttgcca accgctatta ccgccagctg     1560

ttcggctggg aggccgaggg ccacctcaag ctggccggcg acgacctcga caaggaccag     1620

gtctccagcg acaacaccga ctatgtcgac gcctatgccg gcctgccggc gtccgagctg     1680

atgccgtacg catcggacgc gcgcgaagtg ttcgtgccgg acatgcagaa atggttcgaa     1740

gtgcgccgcc gctatatcca gtgggtcgac ggccacctgg cgcagatgca gatcgccacc     1800

gatatcacgg tgcgcaaggc cgccgaggaa atggcgcgcc agcatgaaga gcgcctgcag     1860

ttcaccagcc gcctgaccac catgggcgag atggcctcgt cgctggcgca tgaactgaac     1920

cagccgctgg cggccatcaa caactactgc atgggcgcgg tggcgcggct gcactcgggc     1980

cgcagcacgc cggaggacct gatcccggtg ctggagaaga cctcggccca ggcggtgcgc     2040

gccggcacca tcatcagccg catccgcggc ttcgtgaagc gcagccagcc gcagcggcgc     2100

gaggccgcgc tgcacgacat cgtcgccgac gcggtaggcc tggccgacct ggaggccacg     2160

cgccgccgcg tcaccatcct gacccgcctg ccgaccccgc cgctgacggt ctatgtcgac     2220

ccggtgctga tcgagcaggt gctggtgaac ctgctcaaga acgcggtcga ggccatggcc     2280

ggcctgcccg ccctgcacgc cggcggcgtg gtgcgcctgc acgcgcgggt ggagccgggc     2340

gagattggcg acagcgtcca tatcgacgtg atcgaccagg gcccgggcgt ggacgaagcc     2400

accaaggagc gcctgttcga gcccttcttc agcaccaagt ccgacggcat gggcatgggg     2460

ctgaacatct gccgctcgat catcgagtcg caccagggcc gcctgtgggt ggagaacaat     2520

gccgacggca tcggctgtac atttaaaatc atgctgccgc tgcaatcggc gctggccgag     2580

cattaa                                                                2586


<210>  36
<211>  861
<212>  PRT
<213>  C. necator

<400>  36

Met Pro Phe Phe Asp Arg Leu Leu Ser Ser Leu Arg Ala Ala Met Leu 
1               5                   10                  15      


Pro Pro Asp Ala Ser Gly Ser Ala Lys Ala Ala Gly Gly Asp Pro Ala 
            20                  25                  30          


His Ala Pro Ser Pro Ala Ala Gly Leu Gly Pro Ile Glu Ala Leu Gly 
        35                  40                  45              


Pro Asp Asp Gly Ala Pro Val Ala Ala Pro Arg Gly Leu Trp Trp Leu 
    50                  55                  60                  


Arg Trp Arg Asn Leu Val Ala Thr Ser Trp Phe Met Phe Ile Pro Leu 
65                  70                  75                  80  


Val Ala Ile Val Leu Phe Thr Val Ala Met Gly Val Ile Leu Trp Ser 
                85                  90                  95      


Leu His Glu Thr Glu Arg Gln Gln Gln Arg Asp Ala Leu Tyr Arg Asp 
            100                 105                 110         


Ala Ala Trp Ala Gln Gln Arg Val Arg Leu Ser Leu Leu Ser Asn Gln 
        115                 120                 125             


Asp Gln Leu Ala Ser Leu Ala Arg Asp Ile Ala Ala Ala Gln Leu Glu 
    130                 135                 140                 


Gln Gly Ala Tyr Arg Thr Ala Ala Gln Glu Ile Leu Arg Glu Asn Pro 
145                 150                 155                 160 


Glu Ile Val Phe Ile Asn Trp Leu Asp Ala Thr Lys Arg Gly Arg Trp 
                165                 170                 175     


Ser Leu Pro Ser Thr Ser Glu Phe Ala Ser Arg Leu Arg Glu Asn Gln 
            180                 185                 190         


Asp Gln Pro Leu Glu Pro Glu Val Leu Asp Thr Phe Asp Ala Ala Arg 
        195                 200                 205             


Glu Thr Gln Arg Val Val Tyr Ser Arg Pro Leu Val Asn Glu Arg Gly 
    210                 215                 220                 


Asp Ser Phe Met Leu Met Glu Val Pro Ile Val Arg Asp Asn Glu Phe 
225                 230                 235                 240 


Leu Gly Thr Leu Gly Ala Leu Tyr Ser Ile Asn Gly Ile Leu Thr His 
                245                 250                 255     


Leu Leu Pro Pro Glu Leu Thr Glu Arg Tyr Arg Phe Ser Leu Ile Asp 
            260                 265                 270         


Lys Asn Asn Gln Thr Arg Ala Ser Thr Ser Leu Arg Pro Val Pro Gly 
        275                 280                 285             


Asn Ala Leu Ser Tyr Glu Val Leu Leu Asp Pro Pro Gly His Ser Leu 
    290                 295                 300                 


Ser Leu Arg Ala Asp Ala Tyr Pro Pro Ala Ser Asn Leu Pro Asn Asn 
305                 310                 315                 320 


Met Leu Leu Trp Leu Val Val Gly Leu Ser Cys Phe Leu Leu Trp Ser 
                325                 330                 335     


Leu Trp Ser Met Trp Arg His Thr Ser Arg Arg Ser Glu Ala Gln Arg 
            340                 345                 350         


Ala Leu Leu Ala Glu Thr Ser Phe Arg Arg Ala Met Glu Asn Ser Met 
        355                 360                 365             


Leu Ile Gly Leu Arg Ala Leu Asp Leu Asn Gly Arg Ile Thr Tyr Val 
    370                 375                 380                 


Asn Pro Ala Phe Cys Arg Met Thr Gly Trp Gln Glu Asn Asp Leu Val 
385                 390                 395                 400 


Gly Arg Leu Pro Pro Phe Pro Tyr Trp Pro Pro Asn Asp Gln Gln Glu 
                405                 410                 415     


Met Gln Lys Gln Ile Asp Leu Thr Leu Gln Gly Lys Ser Pro Ala Gly 
            420                 425                 430         


Gly Tyr Glu Met Arg Val Met Arg Arg Asp Gly Ser Ser Phe Tyr Ala 
        435                 440                 445             


Arg Met Tyr Val Ser Pro Leu Val Asp Ser Arg Gly Arg His Thr Gly 
    450                 455                 460                 


Trp Met Ser Ser Met Thr Asp Ile Thr Glu Pro Lys Arg Ala Arg Glu 
465                 470                 475                 480 


Glu Leu Ala Ala Ala His Asp Arg Phe Thr Thr Val Leu Glu Ser Leu 
                485                 490                 495     


Asp Ala Ala Val Ser Val Leu Ala Thr Asp Lys Ala Glu Leu Leu Phe 
            500                 505                 510         


Ala Asn Arg Tyr Tyr Arg Gln Leu Phe Gly Trp Glu Ala Glu Gly His 
        515                 520                 525             


Leu Lys Leu Ala Gly Asp Asp Leu Asp Lys Asp Gln Val Ser Ser Asp 
    530                 535                 540                 


Asn Thr Asp Tyr Val Asp Ala Tyr Ala Gly Leu Pro Ala Ser Glu Leu 
545                 550                 555                 560 


Met Pro Tyr Ala Ser Asp Ala Arg Glu Val Phe Val Pro Asp Met Gln 
                565                 570                 575     


Lys Trp Phe Glu Val Arg Arg Arg Tyr Ile Gln Trp Val Asp Gly His 
            580                 585                 590         


Leu Ala Gln Met Gln Ile Ala Thr Asp Ile Thr Val Arg Lys Ala Ala 
        595                 600                 605             


Glu Glu Met Ala Arg Gln His Glu Glu Arg Leu Gln Phe Thr Ser Arg 
    610                 615                 620                 


Leu Thr Thr Met Gly Glu Met Ala Ser Ser Leu Ala His Glu Leu Asn 
625                 630                 635                 640 


Gln Pro Leu Ala Ala Ile Asn Asn Tyr Cys Met Gly Ala Val Ala Arg 
                645                 650                 655     


Leu His Ser Gly Arg Ser Thr Pro Glu Asp Leu Ile Pro Val Leu Glu 
            660                 665                 670         


Lys Thr Ser Ala Gln Ala Val Arg Ala Gly Thr Ile Ile Ser Arg Ile 
        675                 680                 685             


Arg Gly Phe Val Lys Arg Ser Gln Pro Gln Arg Arg Glu Ala Ala Leu 
    690                 695                 700                 


His Asp Ile Val Ala Asp Ala Val Gly Leu Ala Asp Leu Glu Ala Thr 
705                 710                 715                 720 


Arg Arg Arg Val Thr Ile Leu Thr Arg Leu Pro Thr Pro Pro Leu Thr 
                725                 730                 735     


Val Tyr Val Asp Pro Val Leu Ile Glu Gln Val Leu Val Asn Leu Leu 
            740                 745                 750         


Lys Asn Ala Val Glu Ala Met Ala Gly Leu Pro Ala Leu His Ala Gly 
        755                 760                 765             


Gly Val Val Arg Leu His Ala Arg Val Glu Pro Gly Glu Ile Gly Asp 
    770                 775                 780                 


Ser Val His Ile Asp Val Ile Asp Gln Gly Pro Gly Val Asp Glu Ala 
785                 790                 795                 800 


Thr Lys Glu Arg Leu Phe Glu Pro Phe Phe Ser Thr Lys Ser Asp Gly 
                805                 810                 815     


Met Gly Met Gly Leu Asn Ile Cys Arg Ser Ile Ile Glu Ser His Gln 
            820                 825                 830         


Gly Arg Leu Trp Val Glu Asn Asn Ala Asp Gly Ile Gly Cys Thr Phe 
        835                 840                 845             


Lys Ile Met Leu Pro Leu Gln Ser Ala Leu Ala Glu His 
    850                 855                 860     


<210>  37
<211>  2583
<212>  DNA
<213>  C. necator

<400>  37
atggacacca cgccggaact gctgcttgcc gcgcgcgtgc gcgaccagct caaagccgac       60

aagcaggcac tgtttgccga cttcaacatc agcgccaatg tcggcacgct gatcacgcgg      120

ctgcgccgcg ccgtcgacgc cgggctggtg gaagcctggc gcggcctggg gatgcccgcg      180

ggcgcggcgc tggtggcggt gggcggctat ggccgcggcg agctgctgcc ttactccgac      240

gtcgacgtgc tgctgttgct gcccgccgag ccagaccagg acaccaccgg gcgcctggag      300

cgctttatcg gcctgtgctg ggacctcggg ctggagatcg gctcttcggt gcgcaccgtg      360

gacgattgca tccgcgagtc gcgccaggac gtcaccatcc agacctcgct gctggaagcg      420

cggctgctga ccggcagccg caagctgttc gagtcgatgc gtacgcgcta cctcgccgac      480

ctggacccgg ccgcgttctt ccaggccaag ctgctggaaa tgcgccagcg ccacgccaag      540

taccaggaca cgccctactc gctcgagccc aactgcaagg aaagccccgg cggcctgcgc      600

gatctgcagg tgatcctgtg gatgaccaag gcggcgggcc tgggcgacag ctggaaagaa      660

cttttcgagc gcggcctgct gacgcagcgc gaagcgcagg agctcgcgcg caacgagcgc      720

ctgctcaaga ccatccgcgc gcgcctgcac ctggtggccg gccggcgcca ggacgtgctg      780

gtattcgacc tgcagaccgc gctggcggag tccttcggct atcgccagac caccagcaag      840

cgcgccagcg aacaactgat gcgccgctac tactgggcgg ccaaggcagt cacgcagctc      900

aacagcgtgc tgctgctgaa catcgaggcg atgctgttcc cgagcgagtc tcaggtgacg      960

cgcgtgctca acgagcgctt tgtcgagcgc cagggcatgc tggaaatcac cagcgacgac     1020

atctatgaac gcgacccgca cgcgatcctg gaaaccttcc tgctgtacca gcgcacgccc     1080

ggcgtgaaag gcctgtcgcc gcgcacgctg cgcgggctgt acaacgcgcg caccgtgatg     1140

aatgcgggct ggcgcaacga tccggaaaac cgccgcctgt tcctggccat catgcaggag     1200

ccgcagggca tcacccacgc gctgcgcctg atgaaccaga ccagcgtgct gggccgctac     1260

ctgatcaact tccggcgcat cgtcggccag atgcagcacg acctgttcca cgtctacacc     1320

gtggaccagc acatcctgat ggtggtgcgc aacatgcgcc gcttcgccat cgtcgagcac     1380

acccacgagt tcccgttctg cagccagctg atggccagct tcgacaagcc gtgggtgctg     1440

tgggtggcag cgctgttcca cgacatcgcc aagggccgcg gcggcgacca ctcgaagctt     1500

ggcaccgtgg atgcgcgccg cttctgcaag cagcacggca ttgcgcgcga agacgccgac     1560

ctggtctgct ggctggtcga gcaccacctg accatgagcc acgtggcgca gaagcaggac     1620

ctgaccgatc ccgatgtgat ccacgccttt gcccgcgtgg tcggcagcga acgctacctg     1680

accgcgctct acctgctgac cgtggccgac atccgcggca ccagtcccaa ggtatggaac     1740

gcgtggaagg gcaagctgct ggaagacctg taccacatca cgctgcgcgt gctcggcggc     1800

gcgcgcgtgg attcgcattc gctgtggtcg cagcgcaagg aagacaccat ctccgagctg     1860

cgcctgaagg ccttcgaccc ggcgctgggc aagtccctgt gggcgcagct cgacgtggct     1920

ttcttcctgc gccacgattc gcacgatatc gcctggctca cgcgccacct gtacaacaag     1980

gtggacagcc ccacgccggt ggtcaaggca cgcgtctccc ccgccggcga aggcctgcag     2040

gtggcggtct acgtcaagga ccagcccgac ctgttcgcgc gcatctgcgg ctacttcgag     2100

cgcaaggcat tctcgatcca ggacgccaag atccacacca cgcgccacgg ctacgcgctg     2160

gacacgttcc aggtcaccga ccccggcatg gccggcgacg gcggcagcta ccgcgacatc     2220

atcgcgctgg tcgagcacga actgtgcgag cggctgcgcc tgcaaggcgc actgcccgaa     2280

cccacgcagg ggcggctgtc gcgccagtcg cgcagcttcc cgatcaagcc gcgcgtggac     2340

ctgcgccccg acgagcgcgg ccagtattac ctgctgtcgc tgtccgccaa cgaccgcacc     2400

ggcctgctgt acgccatcgc ccgcgtactg gcacggcatc gcgtatccgt ccacacggca     2460

cgcatcaaca ccctgggcga acgcgtcgaa gacgtgttcc tggtcgacgg cagccgcctg     2520

gctgccgaca accgattgca gattcagctt gaacaggact tgctcgccgc cctcgccatc     2580

tga                                                                   2583


<210>  38
<211>  860
<212>  PRT
<213>  C. necator

<400>  38

Met Asp Thr Thr Pro Glu Leu Leu Leu Ala Ala Arg Val Arg Asp Gln 
1               5                   10                  15      


Leu Lys Ala Asp Lys Gln Ala Leu Phe Ala Asp Phe Asn Ile Ser Ala 
            20                  25                  30          


Asn Val Gly Thr Leu Ile Thr Arg Leu Arg Arg Ala Val Asp Ala Gly 
        35                  40                  45              


Leu Val Glu Ala Trp Arg Gly Leu Gly Met Pro Ala Gly Ala Ala Leu 
    50                  55                  60                  


Val Ala Val Gly Gly Tyr Gly Arg Gly Glu Leu Leu Pro Tyr Ser Asp 
65                  70                  75                  80  


Val Asp Val Leu Leu Leu Leu Pro Ala Glu Pro Asp Gln Asp Thr Thr 
                85                  90                  95      


Gly Arg Leu Glu Arg Phe Ile Gly Leu Cys Trp Asp Leu Gly Leu Glu 
            100                 105                 110         


Ile Gly Ser Ser Val Arg Thr Val Asp Asp Cys Ile Arg Glu Ser Arg 
        115                 120                 125             


Gln Asp Val Thr Ile Gln Thr Ser Leu Leu Glu Ala Arg Leu Leu Thr 
    130                 135                 140                 


Gly Ser Arg Lys Leu Phe Glu Ser Met Arg Thr Arg Tyr Leu Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Ala Ala Phe Phe Gln Ala Lys Leu Leu Glu Met Arg Gln 
                165                 170                 175     


Arg His Ala Lys Tyr Gln Asp Thr Pro Tyr Ser Leu Glu Pro Asn Cys 
            180                 185                 190         


Lys Glu Ser Pro Gly Gly Leu Arg Asp Leu Gln Val Ile Leu Trp Met 
        195                 200                 205             


Thr Lys Ala Ala Gly Leu Gly Asp Ser Trp Lys Glu Leu Phe Glu Arg 
    210                 215                 220                 


Gly Leu Leu Thr Gln Arg Glu Ala Gln Glu Leu Ala Arg Asn Glu Arg 
225                 230                 235                 240 


Leu Leu Lys Thr Ile Arg Ala Arg Leu His Leu Val Ala Gly Arg Arg 
                245                 250                 255     


Gln Asp Val Leu Val Phe Asp Leu Gln Thr Ala Leu Ala Glu Ser Phe 
            260                 265                 270         


Gly Tyr Arg Gln Thr Thr Ser Lys Arg Ala Ser Glu Gln Leu Met Arg 
        275                 280                 285             


Arg Tyr Tyr Trp Ala Ala Lys Ala Val Thr Gln Leu Asn Ser Val Leu 
    290                 295                 300                 


Leu Leu Asn Ile Glu Ala Met Leu Phe Pro Ser Glu Ser Gln Val Thr 
305                 310                 315                 320 


Arg Val Leu Asn Glu Arg Phe Val Glu Arg Gln Gly Met Leu Glu Ile 
                325                 330                 335     


Thr Ser Asp Asp Ile Tyr Glu Arg Asp Pro His Ala Ile Leu Glu Thr 
            340                 345                 350         


Phe Leu Leu Tyr Gln Arg Thr Pro Gly Val Lys Gly Leu Ser Pro Arg 
        355                 360                 365             


Thr Leu Arg Gly Leu Tyr Asn Ala Arg Thr Val Met Asn Ala Gly Trp 
    370                 375                 380                 


Arg Asn Asp Pro Glu Asn Arg Arg Leu Phe Leu Ala Ile Met Gln Glu 
385                 390                 395                 400 


Pro Gln Gly Ile Thr His Ala Leu Arg Leu Met Asn Gln Thr Ser Val 
                405                 410                 415     


Leu Gly Arg Tyr Leu Ile Asn Phe Arg Arg Ile Val Gly Gln Met Gln 
            420                 425                 430         


His Asp Leu Phe His Val Tyr Thr Val Asp Gln His Ile Leu Met Val 
        435                 440                 445             


Val Arg Asn Met Arg Arg Phe Ala Ile Val Glu His Thr His Glu Phe 
    450                 455                 460                 


Pro Phe Cys Ser Gln Leu Met Ala Ser Phe Asp Lys Pro Trp Val Leu 
465                 470                 475                 480 


Trp Val Ala Ala Leu Phe His Asp Ile Ala Lys Gly Arg Gly Gly Asp 
                485                 490                 495     


His Ser Lys Leu Gly Thr Val Asp Ala Arg Arg Phe Cys Lys Gln His 
            500                 505                 510         


Gly Ile Ala Arg Glu Asp Ala Asp Leu Val Cys Trp Leu Val Glu His 
        515                 520                 525             


His Leu Thr Met Ser His Val Ala Gln Lys Gln Asp Leu Thr Asp Pro 
    530                 535                 540                 


Asp Val Ile His Ala Phe Ala Arg Val Val Gly Ser Glu Arg Tyr Leu 
545                 550                 555                 560 


Thr Ala Leu Tyr Leu Leu Thr Val Ala Asp Ile Arg Gly Thr Ser Pro 
                565                 570                 575     


Lys Val Trp Asn Ala Trp Lys Gly Lys Leu Leu Glu Asp Leu Tyr His 
            580                 585                 590         


Ile Thr Leu Arg Val Leu Gly Gly Ala Arg Val Asp Ser His Ser Leu 
        595                 600                 605             


Trp Ser Gln Arg Lys Glu Asp Thr Ile Ser Glu Leu Arg Leu Lys Ala 
    610                 615                 620                 


Phe Asp Pro Ala Leu Gly Lys Ser Leu Trp Ala Gln Leu Asp Val Ala 
625                 630                 635                 640 


Phe Phe Leu Arg His Asp Ser His Asp Ile Ala Trp Leu Thr Arg His 
                645                 650                 655     


Leu Tyr Asn Lys Val Asp Ser Pro Thr Pro Val Val Lys Ala Arg Val 
            660                 665                 670         


Ser Pro Ala Gly Glu Gly Leu Gln Val Ala Val Tyr Val Lys Asp Gln 
        675                 680                 685             


Pro Asp Leu Phe Ala Arg Ile Cys Gly Tyr Phe Glu Arg Lys Ala Phe 
    690                 695                 700                 


Ser Ile Gln Asp Ala Lys Ile His Thr Thr Arg His Gly Tyr Ala Leu 
705                 710                 715                 720 


Asp Thr Phe Gln Val Thr Asp Pro Gly Met Ala Gly Asp Gly Gly Ser 
                725                 730                 735     


Tyr Arg Asp Ile Ile Ala Leu Val Glu His Glu Leu Cys Glu Arg Leu 
            740                 745                 750         


Arg Leu Gln Gly Ala Leu Pro Glu Pro Thr Gln Gly Arg Leu Ser Arg 
        755                 760                 765             


Gln Ser Arg Ser Phe Pro Ile Lys Pro Arg Val Asp Leu Arg Pro Asp 
    770                 775                 780                 


Glu Arg Gly Gln Tyr Tyr Leu Leu Ser Leu Ser Ala Asn Asp Arg Thr 
785                 790                 795                 800 


Gly Leu Leu Tyr Ala Ile Ala Arg Val Leu Ala Arg His Arg Val Ser 
                805                 810                 815     


Val His Thr Ala Arg Ile Asn Thr Leu Gly Glu Arg Val Glu Asp Val 
            820                 825                 830         


Phe Leu Val Asp Gly Ser Arg Leu Ala Ala Asp Asn Arg Leu Gln Ile 
        835                 840                 845             


Gln Leu Glu Gln Asp Leu Leu Ala Ala Leu Ala Ile 
    850                 855                 860 


<210>  39
<211>  1548
<212>  DNA
<213>  C. necator

<400>  39
atgaagccga tctggatagt cgacgacgat caatcaatcc gctgggtcct ggaaaaggcc       60

ctggcccgtg aaagcctgct ctcgcgcagc ttcaccaatg tgcgggatgc gctggccgcg      120

ctggaagaag accagcccca ggtgctgata tcggatatcc gcatgcccgg cggatcgggc      180

ctggacctgc tgcaggccat caaggcgcgg catccgggcc tgccggtcat cgtgatgacg      240

gcctactctg acctggacag cgccgtggcc gcgttccagg gcggtgcctt cgaatacctg      300

gccaagccct tcgatgtcga caaggcggtt gagctgatcc gccgcgcgct ggaagaaagc      360

ctgcgcgagg aagaactgga cgaccgcctc gtcgatgcgc ccgagatcct cggccaggcg      420

ccggcgatgc aggacgtgtt ccgcgccatc ggccggctct cgcagtccaa cgtgacggtg      480

atgatcaccg gcgagtctgg caccggcaag gagctggtcg cacgcgcgct gcacaagcac      540

agcccgcgtg ccaacggtcc ctttatcgcg ctcaataccg cggccatccc caaggacctg      600

ctcgaatccg aactgttcgg ccatgagcgc ggcgccttca ccggtgcgca gaccatgcgg      660

cgcggccgct tcgagcaggc cgagggcggc acgctgttcc tcgacgaaat cggcgatatg      720

ccgttcgacc tgcagacgcg cctgctgcgc gtgctgtccg atggcaactt ctatcgtgtc      780

ggcggccaca accccttgcg cgccaatgtg cgcgtgattg ccgccaccca ccagaacctg      840

gagctgcgcg tcaaggaagg gctgttccgc gaggacttgt tccaccgcct gaacgtgatc      900

cggttgcgcc tgccgccgct gcgcgaacgc ccggaggaca tcacgctgct ggcgcgtcat      960

ttcctgcaga agagcgccaa ggaactgggc gtcgagccca agcgcatgtc cgacgaagcg     1020

ctggcctatg tcagcacgct gccattcccc ggcaacgtgc gccagctgga gaacctgtgc     1080

aactggctga ccgtgatggc gccggcccag accatcgagg tcaaggacct gccgcgcgag     1140

atgctggaag ccggcaccag cgagccggtc aatgcgccgc ggcccgagcg cgttgccgaa     1200

gcgcgcgcgc ccgagtatga aagcgcgcct gacctggccg actacggcgg ctacgcgacg     1260

acggtggcag aggccgacac ggccaccgca gtccggcccg cgtccgtggc gacggtggtc     1320

ccggccctgg cctcggccgg ctgggaaagc ctgctcgccg gcgaagcacg ggcaatgctc     1380

gaagccggcc agccggaggt catggatgtg ctgacgcgcc gcttcgagaa ggccgtgctg     1440

gaggccgcgc tgggtgtcac gcgcgggcgc cgcgtcgagg cggcgacccg gctcgggatc     1500

gggcgcaata ccatcacgcg caagctgcag gagcttgggt tcgactga                  1548


<210>  40
<211>  515
<212>  PRT
<213>  C. necator

<400>  40

Met Lys Pro Ile Trp Ile Val Asp Asp Asp Gln Ser Ile Arg Trp Val 
1               5                   10                  15      


Leu Glu Lys Ala Leu Ala Arg Glu Ser Leu Leu Ser Arg Ser Phe Thr 
            20                  25                  30          


Asn Val Arg Asp Ala Leu Ala Ala Leu Glu Glu Asp Gln Pro Gln Val 
        35                  40                  45              


Leu Ile Ser Asp Ile Arg Met Pro Gly Gly Ser Gly Leu Asp Leu Leu 
    50                  55                  60                  


Gln Ala Ile Lys Ala Arg His Pro Gly Leu Pro Val Ile Val Met Thr 
65                  70                  75                  80  


Ala Tyr Ser Asp Leu Asp Ser Ala Val Ala Ala Phe Gln Gly Gly Ala 
                85                  90                  95      


Phe Glu Tyr Leu Ala Lys Pro Phe Asp Val Asp Lys Ala Val Glu Leu 
            100                 105                 110         


Ile Arg Arg Ala Leu Glu Glu Ser Leu Arg Glu Glu Glu Leu Asp Asp 
        115                 120                 125             


Arg Leu Val Asp Ala Pro Glu Ile Leu Gly Gln Ala Pro Ala Met Gln 
    130                 135                 140                 


Asp Val Phe Arg Ala Ile Gly Arg Leu Ser Gln Ser Asn Val Thr Val 
145                 150                 155                 160 


Met Ile Thr Gly Glu Ser Gly Thr Gly Lys Glu Leu Val Ala Arg Ala 
                165                 170                 175     


Leu His Lys His Ser Pro Arg Ala Asn Gly Pro Phe Ile Ala Leu Asn 
            180                 185                 190         


Thr Ala Ala Ile Pro Lys Asp Leu Leu Glu Ser Glu Leu Phe Gly His 
        195                 200                 205             


Glu Arg Gly Ala Phe Thr Gly Ala Gln Thr Met Arg Arg Gly Arg Phe 
    210                 215                 220                 


Glu Gln Ala Glu Gly Gly Thr Leu Phe Leu Asp Glu Ile Gly Asp Met 
225                 230                 235                 240 


Pro Phe Asp Leu Gln Thr Arg Leu Leu Arg Val Leu Ser Asp Gly Asn 
                245                 250                 255     


Phe Tyr Arg Val Gly Gly His Asn Pro Leu Arg Ala Asn Val Arg Val 
            260                 265                 270         


Ile Ala Ala Thr His Gln Asn Leu Glu Leu Arg Val Lys Glu Gly Leu 
        275                 280                 285             


Phe Arg Glu Asp Leu Phe His Arg Leu Asn Val Ile Arg Leu Arg Leu 
    290                 295                 300                 


Pro Pro Leu Arg Glu Arg Pro Glu Asp Ile Thr Leu Leu Ala Arg His 
305                 310                 315                 320 


Phe Leu Gln Lys Ser Ala Lys Glu Leu Gly Val Glu Pro Lys Arg Met 
                325                 330                 335     


Ser Asp Glu Ala Leu Ala Tyr Val Ser Thr Leu Pro Phe Pro Gly Asn 
            340                 345                 350         


Val Arg Gln Leu Glu Asn Leu Cys Asn Trp Leu Thr Val Met Ala Pro 
        355                 360                 365             


Ala Gln Thr Ile Glu Val Lys Asp Leu Pro Arg Glu Met Leu Glu Ala 
    370                 375                 380                 


Gly Thr Ser Glu Pro Val Asn Ala Pro Arg Pro Glu Arg Val Ala Glu 
385                 390                 395                 400 


Ala Arg Ala Pro Glu Tyr Glu Ser Ala Pro Asp Leu Ala Asp Tyr Gly 
                405                 410                 415     


Gly Tyr Ala Thr Thr Val Ala Glu Ala Asp Thr Ala Thr Ala Val Arg 
            420                 425                 430         


Pro Ala Ser Val Ala Thr Val Val Pro Ala Leu Ala Ser Ala Gly Trp 
        435                 440                 445             


Glu Ser Leu Leu Ala Gly Glu Ala Arg Ala Met Leu Glu Ala Gly Gln 
    450                 455                 460                 


Pro Glu Val Met Asp Val Leu Thr Arg Arg Phe Glu Lys Ala Val Leu 
465                 470                 475                 480 


Glu Ala Ala Leu Gly Val Thr Arg Gly Arg Arg Val Glu Ala Ala Thr 
                485                 490                 495     


Arg Leu Gly Ile Gly Arg Asn Thr Ile Thr Arg Lys Leu Gln Glu Leu 
            500                 505                 510         


Gly Phe Asp 
        515 


<210>  41
<211>  1179
<212>  DNA
<213>  C. necator

<400>  41
atgcgtcgcc tgattcgcgg agtgtcgcgc aaggccagcg gtgccgacgg cgcccgtggc       60

gaatcgccgg cggctgatgc ggcgccggcc gaaggcagcg cccaggtgct gaccatgggc      120

gccgtggcgt tccatgccgg cctggacgta gtggccaacc cggtgctgct ggtgcagcag      180

ccggggctgc gcgtcgtctt tgcgaacccg gccgctgaag ccaccttcgg cgtgtcgcgc      240

aagggcatgg tggagctgac gctgcctgac ctgttcgggc gttccgatga gctgcacagc      300

atgatcgaca ccgtggtcac gcggcagttc gacgtgcgcc ggcaggacct gatcctgcac      360

ccgccgctgc aggagccggc ccatgtgcac gtggtgatct ccgcgctgga agcggtcggc      420

gacaccgtgg tggtggaaat cctgcccaat gaacagaagg tgcgcagcga acgcgaagaa      480

cgcatcctgg acctgacctc ggccaacaag gaactgatcc gcaacctggc ccacgaaatc      540

aagaacccgc tgggcggcat tcgcggcgcg gcgcagctgc tggagttcga gctgccggag      600

cgctcgctgc gcgaatacac gcaggtcatc atcaaggaat cggaccggct gcagacgctg      660

gtggaccggc tgctggagcc gcaccggcat ccgcatatcg tgtccagcct gaatatccac      720

gaagtgctgg agcgcgtgcg ctcggtggtg ctggcggagt tccccaacgg gctggagatc      780

gtgcgcgact acgacgccag cctgcccgag ctgcagggcg acatggagca actgatccag      840

gccgtgctca acatcgtgca caacgccgcg caggcgctgg ccgaccgcat ggcgcgcggc      900

gatgcacaga tcgtgctgcg cacgcgcgtg gcgcgccagg tcacgattgc caagcgcttg      960

ttcaagctgg cattggactt gcatgtcatc gacaacggcc cgggaatttc cgaagacatc     1020

cgcgaacgca tcttctatcc gctggtatcg ggcagggatg gcggcagcgg actcggtctc     1080

acactcgctc aaaccttcgt gcagcagcac gagggcttga tcgaatgcga gagcaggccg     1140

ggctgtaccg acttccgcat cctgctgccg ctgcactag                            1179


<210>  42
<211>  392
<212>  PRT
<213>  C. necator

<400>  42

Met Arg Arg Leu Ile Arg Gly Val Ser Arg Lys Ala Ser Gly Ala Asp 
1               5                   10                  15      


Gly Ala Arg Gly Glu Ser Pro Ala Ala Asp Ala Ala Pro Ala Glu Gly 
            20                  25                  30          


Ser Ala Gln Val Leu Thr Met Gly Ala Val Ala Phe His Ala Gly Leu 
        35                  40                  45              


Asp Val Val Ala Asn Pro Val Leu Leu Val Gln Gln Pro Gly Leu Arg 
    50                  55                  60                  


Val Val Phe Ala Asn Pro Ala Ala Glu Ala Thr Phe Gly Val Ser Arg 
65                  70                  75                  80  


Lys Gly Met Val Glu Leu Thr Leu Pro Asp Leu Phe Gly Arg Ser Asp 
                85                  90                  95      


Glu Leu His Ser Met Ile Asp Thr Val Val Thr Arg Gln Phe Asp Val 
            100                 105                 110         


Arg Arg Gln Asp Leu Ile Leu His Pro Pro Leu Gln Glu Pro Ala His 
        115                 120                 125             


Val His Val Val Ile Ser Ala Leu Glu Ala Val Gly Asp Thr Val Val 
    130                 135                 140                 


Val Glu Ile Leu Pro Asn Glu Gln Lys Val Arg Ser Glu Arg Glu Glu 
145                 150                 155                 160 


Arg Ile Leu Asp Leu Thr Ser Ala Asn Lys Glu Leu Ile Arg Asn Leu 
                165                 170                 175     


Ala His Glu Ile Lys Asn Pro Leu Gly Gly Ile Arg Gly Ala Ala Gln 
            180                 185                 190         


Leu Leu Glu Phe Glu Leu Pro Glu Arg Ser Leu Arg Glu Tyr Thr Gln 
        195                 200                 205             


Val Ile Ile Lys Glu Ser Asp Arg Leu Gln Thr Leu Val Asp Arg Leu 
    210                 215                 220                 


Leu Glu Pro His Arg His Pro His Ile Val Ser Ser Leu Asn Ile His 
225                 230                 235                 240 


Glu Val Leu Glu Arg Val Arg Ser Val Val Leu Ala Glu Phe Pro Asn 
                245                 250                 255     


Gly Leu Glu Ile Val Arg Asp Tyr Asp Ala Ser Leu Pro Glu Leu Gln 
            260                 265                 270         


Gly Asp Met Glu Gln Leu Ile Gln Ala Val Leu Asn Ile Val His Asn 
        275                 280                 285             


Ala Ala Gln Ala Leu Ala Asp Arg Met Ala Arg Gly Asp Ala Gln Ile 
    290                 295                 300                 


Val Leu Arg Thr Arg Val Ala Arg Gln Val Thr Ile Ala Lys Arg Leu 
305                 310                 315                 320 


Phe Lys Leu Ala Leu Asp Leu His Val Ile Asp Asn Gly Pro Gly Ile 
                325                 330                 335     


Ser Glu Asp Ile Arg Glu Arg Ile Phe Tyr Pro Leu Val Ser Gly Arg 
            340                 345                 350         


Asp Gly Gly Ser Gly Leu Gly Leu Thr Leu Ala Gln Thr Phe Val Gln 
        355                 360                 365             


Gln His Glu Gly Leu Ile Glu Cys Glu Ser Arg Pro Gly Cys Thr Asp 
    370                 375                 380                 


Phe Arg Ile Leu Leu Pro Leu His 
385                 390         


<210>  43
<211>  1416
<212>  DNA
<213>  C. necator

<400>  43
atggcccaca gcgttgcaga cgtgatgaag ctggtgaagg aaaacgacgt caagttcgtc       60

gatttccgtt tcaccgatac caaaggcaag gagcaacacg tgtccgtgcc cgtgtcgcac      120

ttcgatgaag acaagttcga aagcggccac gccttcgacg gttcgtcgat cgccggctgg      180

aagggtatcg aagcttcaga catgctgctg atgccggatt cgaacaccgc ccacatcgac      240

ccgttctacg aagagccgac gctggtgctg tcctgcgacg tggtcgagcc gtcggacggc      300

aagggctatg accgcgaccc gcgttccatc gccaagcgcg ccgaagccta cctgaagagc      360

accggcctgg gcgacaccgc tttctttggt ccggagcccg agttcttcat cttcgacggc      420

gtgacctgga acgtcgacat gcaaggctgc ttcgtgaaga tccattccga agaagccccg      480

tggtcgtcgg ccaaggaatt cgagcacggc aacagcggcc accgtccggg caagaagggc      540

ggctacttcc cggtcgcccc gatcgacacc ttccaggaca tgcgttcgga aatgtgcctg      600

atcctggaat cgctgggcat ccccgttgaa gtccaccacc acgaagtggc tggccagggc      660

cagaacgaaa tcggcacccg cttcagcacg ctggtgcagc gcgccgactg gacccagatg      720

cagaagtacg tgatccagaa cgtcgcccac acctacggca agaccgccac cttcatgccg      780

aagccgatcg ttggcgacaa cggttcgggc atgcacgtgc accagtccgt gtggaaggac      840

ggccagaacc tgttcgcggg caacggctac gccggcctgt cggaattcgc gctgtactac      900

atcggcggca tcatcaagca cgcccgtgcc ctgaatgcca tcaccaaccc gggcacgaac      960

tcgtacaagc gcctggtgcc gggcttcgaa gctccggtga agctggccta ctcggcccgc     1020

aaccgctcgg cttcgatccg catcccgtat gtggccaacc cgaagggccg ccgcatcgag     1080

acccgcttcc cggatccgct gatgaacccg tacctgggct tctcggcgct gctgatggcc     1140

ggcctggatg gcgtgatgaa caagatccac ccgggcgaag ctgccgacaa gaacctgtac     1200

gacctgccgc cggaagagga tgcaaagatc ccgaccgtgt gctcgagcct ggaccaggcg     1260

ctggagtacc tggacaacga ccgcgagttc ctgacccgcg gcggcgtgtt ctcgaactcg     1320

atgatcgatg cctacatcga actgaagatg gaagaagtca cgcgtttccg catgaccacg     1380

cacccggtcg agttcgaaat gtactactcg ctgtaa                               1416


<210>  44
<211>  471
<212>  PRT
<213>  C. necator

<400>  44

Met Ala His Ser Val Ala Asp Val Met Lys Leu Val Lys Glu Asn Asp 
1               5                   10                  15      


Val Lys Phe Val Asp Phe Arg Phe Thr Asp Thr Lys Gly Lys Glu Gln 
            20                  25                  30          


His Val Ser Val Pro Val Ser His Phe Asp Glu Asp Lys Phe Glu Ser 
        35                  40                  45              


Gly His Ala Phe Asp Gly Ser Ser Ile Ala Gly Trp Lys Gly Ile Glu 
    50                  55                  60                  


Ala Ser Asp Met Leu Leu Met Pro Asp Ser Asn Thr Ala His Ile Asp 
65                  70                  75                  80  


Pro Phe Tyr Glu Glu Pro Thr Leu Val Leu Ser Cys Asp Val Val Glu 
                85                  90                  95      


Pro Ser Asp Gly Lys Gly Tyr Asp Arg Asp Pro Arg Ser Ile Ala Lys 
            100                 105                 110         


Arg Ala Glu Ala Tyr Leu Lys Ser Thr Gly Leu Gly Asp Thr Ala Phe 
        115                 120                 125             


Phe Gly Pro Glu Pro Glu Phe Phe Ile Phe Asp Gly Val Thr Trp Asn 
    130                 135                 140                 


Val Asp Met Gln Gly Cys Phe Val Lys Ile His Ser Glu Glu Ala Pro 
145                 150                 155                 160 


Trp Ser Ser Ala Lys Glu Phe Glu His Gly Asn Ser Gly His Arg Pro 
                165                 170                 175     


Gly Lys Lys Gly Gly Tyr Phe Pro Val Ala Pro Ile Asp Thr Phe Gln 
            180                 185                 190         


Asp Met Arg Ser Glu Met Cys Leu Ile Leu Glu Ser Leu Gly Ile Pro 
        195                 200                 205             


Val Glu Val His His His Glu Val Ala Gly Gln Gly Gln Asn Glu Ile 
    210                 215                 220                 


Gly Thr Arg Phe Ser Thr Leu Val Gln Arg Ala Asp Trp Thr Gln Met 
225                 230                 235                 240 


Gln Lys Tyr Val Ile Gln Asn Val Ala His Thr Tyr Gly Lys Thr Ala 
                245                 250                 255     


Thr Phe Met Pro Lys Pro Ile Val Gly Asp Asn Gly Ser Gly Met His 
            260                 265                 270         


Val His Gln Ser Val Trp Lys Asp Gly Gln Asn Leu Phe Ala Gly Asn 
        275                 280                 285             


Gly Tyr Ala Gly Leu Ser Glu Phe Ala Leu Tyr Tyr Ile Gly Gly Ile 
    290                 295                 300                 


Ile Lys His Ala Arg Ala Leu Asn Ala Ile Thr Asn Pro Gly Thr Asn 
305                 310                 315                 320 


Ser Tyr Lys Arg Leu Val Pro Gly Phe Glu Ala Pro Val Lys Leu Ala 
                325                 330                 335     


Tyr Ser Ala Arg Asn Arg Ser Ala Ser Ile Arg Ile Pro Tyr Val Ala 
            340                 345                 350         


Asn Pro Lys Gly Arg Arg Ile Glu Thr Arg Phe Pro Asp Pro Leu Met 
        355                 360                 365             


Asn Pro Tyr Leu Gly Phe Ser Ala Leu Leu Met Ala Gly Leu Asp Gly 
    370                 375                 380                 


Val Met Asn Lys Ile His Pro Gly Glu Ala Ala Asp Lys Asn Leu Tyr 
385                 390                 395                 400 


Asp Leu Pro Pro Glu Glu Asp Ala Lys Ile Pro Thr Val Cys Ser Ser 
                405                 410                 415     


Leu Asp Gln Ala Leu Glu Tyr Leu Asp Asn Asp Arg Glu Phe Leu Thr 
            420                 425                 430         


Arg Gly Gly Val Phe Ser Asn Ser Met Ile Asp Ala Tyr Ile Glu Leu 
        435                 440                 445             


Lys Met Glu Glu Val Thr Arg Phe Arg Met Thr Thr His Pro Val Glu 
    450                 455                 460                 


Phe Glu Met Tyr Tyr Ser Leu 
465                 470     


<210>  45
<211>  771
<212>  DNA
<213>  C. necator

<400>  45
atgaccctga atccccgcca gacggccctg ctcgaagaag tccgcaccca gggctttgcc       60

tccatcgacg aacttgcgcg caaattcggc gtcacgctcc agacggtgcg ccgcgatgtc      120

aacctgctgg ccgggaacgg catgctggcg cgcttccatg gcggggtgcg ggtggagggc      180

tccaccaccg agaacatcgc ctaccggcag cggcaggtgc tcaacgccga gggcaaggcg      240

cgcatcgcgc gcgcggtggc cgctgcggtg cccgagggct gctcgctgat cctgaacatc      300

ggcaccacgg tggaagagat agcgcgcgaa ctgatgcacc accgcgggct gcgcgtgatc      360

accaacaacc tgaatgtggc caatatcctt gccgacaacc ccgattgcga ggtcatcgtc      420

gccggcggcg tgctgcgctc acgcgaccgc ggcatcgtgg gcgaggccac ggtggagttc      480

atccgccagt tcaaggtgga tatcgggctg atcggcatct cgggcatcga gaccgacggc      540

acgctgcgcg actacgattt ccgcgaggtc aaggtggcgc ggaccatcat cgagcattca      600

cgcgaggtgt ggctggcggc ggacgccagc aagttcaatc gccaggcgat ggtggagctg      660

gcgcatgtgt cgcaggtcga ccggctcttt accgacgagc cgctggcagc gccgttcgac      720

cagatcgtgg ccgacagtgg ggtgaagtgt gtggtggcgg agcgggagtg a               771


<210>  46
<211>  256
<212>  PRT
<213>  C. necator

<400>  46

Met Thr Leu Asn Pro Arg Gln Thr Ala Leu Leu Glu Glu Val Arg Thr 
1               5                   10                  15      


Gln Gly Phe Ala Ser Ile Asp Glu Leu Ala Arg Lys Phe Gly Val Thr 
            20                  25                  30          


Leu Gln Thr Val Arg Arg Asp Val Asn Leu Leu Ala Gly Asn Gly Met 
        35                  40                  45              


Leu Ala Arg Phe His Gly Gly Val Arg Val Glu Gly Ser Thr Thr Glu 
    50                  55                  60                  


Asn Ile Ala Tyr Arg Gln Arg Gln Val Leu Asn Ala Glu Gly Lys Ala 
65                  70                  75                  80  


Arg Ile Ala Arg Ala Val Ala Ala Ala Val Pro Glu Gly Cys Ser Leu 
                85                  90                  95      


Ile Leu Asn Ile Gly Thr Thr Val Glu Glu Ile Ala Arg Glu Leu Met 
            100                 105                 110         


His His Arg Gly Leu Arg Val Ile Thr Asn Asn Leu Asn Val Ala Asn 
        115                 120                 125             


Ile Leu Ala Asp Asn Pro Asp Cys Glu Val Ile Val Ala Gly Gly Val 
    130                 135                 140                 


Leu Arg Ser Arg Asp Arg Gly Ile Val Gly Glu Ala Thr Val Glu Phe 
145                 150                 155                 160 


Ile Arg Gln Phe Lys Val Asp Ile Gly Leu Ile Gly Ile Ser Gly Ile 
                165                 170                 175     


Glu Thr Asp Gly Thr Leu Arg Asp Tyr Asp Phe Arg Glu Val Lys Val 
            180                 185                 190         


Ala Arg Thr Ile Ile Glu His Ser Arg Glu Val Trp Leu Ala Ala Asp 
        195                 200                 205             


Ala Ser Lys Phe Asn Arg Gln Ala Met Val Glu Leu Ala His Val Ser 
    210                 215                 220                 


Gln Val Asp Arg Leu Phe Thr Asp Glu Pro Leu Ala Ala Pro Phe Asp 
225                 230                 235                 240 


Gln Ile Val Ala Asp Ser Gly Val Lys Cys Val Val Ala Glu Arg Glu 
                245                 250                 255     


<210>  47
<211>  1464
<212>  DNA
<213>  C. necator

<400>  47
atgggtaagg cgactggctt tctcgaattt ccgcgccaga acgaaggcta cgaaccggta       60

gtcaagcgcg tgaagcacta caaggaattc gtgttcgcgc tgtccgacag cgaagcgaag      120

atccagggtg cgcgctgcat ggactgcggc atcccgttct gcaacaacgg ctgcccggtc      180

aacaacatca tccccgactt caacgacctg gtgtaccgcc aggactggaa gtcggcgatc      240

gaggtgctgc accagaccaa caacttcccc gagttcaccg gccgcatctg ccccgcaccg      300

tgcgaggccg cctgcacgct gggcatcaat gaactgccgg tgggcatcaa gtcgatcgag      360

cacgccatca tcgacaaggc ctgggaagag ggctgggtca ggccgcagct gccgcgccac      420

aagaccggca agaccgtggc cgtggtcggc tccggtcccg ccggcatggc tgccgcgcag      480

cagctggcac gcgccggcca tgacgtgacc gtgttcgaga agaacgaccg catcggcggc      540

ctgctgcgct acggcatccc cgacttcaag atggagaaga cgctgatcga ccgccgcatc      600

gagcagatgc aggccgaagg cgtgaccttc cgtccgggcg tgatggtgac cgacggcgaa      660

ctgccggccg gcatcaagaa ctacgcccgt gaaaccatct cggcccaggc cctgatggac      720

cagttcgacg ccgtggtgct ggcgggcggc tcggaagtgc cgcgcgacct gccggtgccg      780

ggccgcgacc tggccggcat ccacttcgcg ctggaattcc tgatcccgca gaacaaggaa      840

gtggcaggcg acggcgaaaa cgagatccgc gccgaaggca agaacgtgat tgtgatcggt      900

ggcggcgata ccggctccga ctgcgtgggt acgtccaacc gccatggcgc cacctcggtg      960

acgcagtttg aactgctgcc gcagccgccg gaagaagagg acaagccgct ggtgtggccg     1020

tactggccga tcaagctgcg cacctcgtcg tcgcacgatg aaggctgcga gcgagactgg     1080

tcggtcgcca ccaaggaatt catcggcgag aacggcaagg tcaccgcact gaaggcctgc     1140

cgtgtcgaat ggaaggatgg ccgcatgcag gaagtcgaag gcagcgagtt catcctgccg     1200

gccgacctgg tgctgctggc gatgggcttt accaacccgg tgggttcgat gctggaagcg     1260

tttggcgtgg ataccgatgc gcgcaagaac gccaaggcct cgaccgaggg cgagcgtgcc     1320

taccacacca acgtgcccaa ggtgttcgcc gctggcgacg tgcgccgtgg ccagtcgctg     1380

gtggtgtggg cgatccgcga aggccgccag gccgcgcgtt cggtcgatgc cttcctgatg     1440

ggtcacaccg aactgccgcg ctga                                            1464


<210>  48
<211>  487
<212>  PRT
<213>  C. necator

<400>  48

Met Gly Lys Ala Thr Gly Phe Leu Glu Phe Pro Arg Gln Asn Glu Gly 
1               5                   10                  15      


Tyr Glu Pro Val Val Lys Arg Val Lys His Tyr Lys Glu Phe Val Phe 
            20                  25                  30          


Ala Leu Ser Asp Ser Glu Ala Lys Ile Gln Gly Ala Arg Cys Met Asp 
        35                  40                  45              


Cys Gly Ile Pro Phe Cys Asn Asn Gly Cys Pro Val Asn Asn Ile Ile 
    50                  55                  60                  


Pro Asp Phe Asn Asp Leu Val Tyr Arg Gln Asp Trp Lys Ser Ala Ile 
65                  70                  75                  80  


Glu Val Leu His Gln Thr Asn Asn Phe Pro Glu Phe Thr Gly Arg Ile 
                85                  90                  95      


Cys Pro Ala Pro Cys Glu Ala Ala Cys Thr Leu Gly Ile Asn Glu Leu 
            100                 105                 110         


Pro Val Gly Ile Lys Ser Ile Glu His Ala Ile Ile Asp Lys Ala Trp 
        115                 120                 125             


Glu Glu Gly Trp Val Arg Pro Gln Leu Pro Arg His Lys Thr Gly Lys 
    130                 135                 140                 


Thr Val Ala Val Val Gly Ser Gly Pro Ala Gly Met Ala Ala Ala Gln 
145                 150                 155                 160 


Gln Leu Ala Arg Ala Gly His Asp Val Thr Val Phe Glu Lys Asn Asp 
                165                 170                 175     


Arg Ile Gly Gly Leu Leu Arg Tyr Gly Ile Pro Asp Phe Lys Met Glu 
            180                 185                 190         


Lys Thr Leu Ile Asp Arg Arg Ile Glu Gln Met Gln Ala Glu Gly Val 
        195                 200                 205             


Thr Phe Arg Pro Gly Val Met Val Thr Asp Gly Glu Leu Pro Ala Gly 
    210                 215                 220                 


Ile Lys Asn Tyr Ala Arg Glu Thr Ile Ser Ala Gln Ala Leu Met Asp 
225                 230                 235                 240 


Gln Phe Asp Ala Val Val Leu Ala Gly Gly Ser Glu Val Pro Arg Asp 
                245                 250                 255     


Leu Pro Val Pro Gly Arg Asp Leu Ala Gly Ile His Phe Ala Leu Glu 
            260                 265                 270         


Phe Leu Ile Pro Gln Asn Lys Glu Val Ala Gly Asp Gly Glu Asn Glu 
        275                 280                 285             


Ile Arg Ala Glu Gly Lys Asn Val Ile Val Ile Gly Gly Gly Asp Thr 
    290                 295                 300                 


Gly Ser Asp Cys Val Gly Thr Ser Asn Arg His Gly Ala Thr Ser Val 
305                 310                 315                 320 


Thr Gln Phe Glu Leu Leu Pro Gln Pro Pro Glu Glu Glu Asp Lys Pro 
                325                 330                 335     


Leu Val Trp Pro Tyr Trp Pro Ile Lys Leu Arg Thr Ser Ser Ser His 
            340                 345                 350         


Asp Glu Gly Cys Glu Arg Asp Trp Ser Val Ala Thr Lys Glu Phe Ile 
        355                 360                 365             


Gly Glu Asn Gly Lys Val Thr Ala Leu Lys Ala Cys Arg Val Glu Trp 
    370                 375                 380                 


Lys Asp Gly Arg Met Gln Glu Val Glu Gly Ser Glu Phe Ile Leu Pro 
385                 390                 395                 400 


Ala Asp Leu Val Leu Leu Ala Met Gly Phe Thr Asn Pro Val Gly Ser 
                405                 410                 415     


Met Leu Glu Ala Phe Gly Val Asp Thr Asp Ala Arg Lys Asn Ala Lys 
            420                 425                 430         


Ala Ser Thr Glu Gly Glu Arg Ala Tyr His Thr Asn Val Pro Lys Val 
        435                 440                 445             


Phe Ala Ala Gly Asp Val Arg Arg Gly Gln Ser Leu Val Val Trp Ala 
    450                 455                 460                 


Ile Arg Glu Gly Arg Gln Ala Ala Arg Ser Val Asp Ala Phe Leu Met 
465                 470                 475                 480 


Gly His Thr Glu Leu Pro Arg 
                485         


<210>  49
<211>  4806
<212>  DNA
<213>  C. necator

<400>  49
gtggaccaaa cgaaaaatct ttcggcccaa gctcaggcac aagcgcagac cagcgagtct       60

tcccacgcca ttgacctgcg cccgcaagcg cagggcatgt acgatcccag caacgagcat      120

gacgcctgcg gcgtcggcat ggtcgcgcat atcaagggca agaagtccca cgagatcatc      180

tcgcagggcc tgaagatcct ggagaacctg gaccaccggg gtgcggtcgg cgccgatgcg      240

ctgatgggcg acggtgccgg catcctgatc cagatcccgg accagttcta ccgcgaggaa      300

atggccgcgc agggcgtgag cctgccgccc gccggcgaat acggcgtggg catgatcttc      360

ctgccgaagg aacacgcctc gcgcctggcc tgcgagcagg aactggagcg cacggtccgc      420

ctggaaggcc aggtcgtgct gggctggcgc gacgtgccgg tcgacgccaa gatgccgatg      480

tcgccgacgg tgcgcaccac cgagccggtg atccgccaga tcttcatcgg gcgcggccgc      540

gacatcatga ccacggacgc gctggaacgt aagctctacg tcatccgcaa gaccgccagc      600

catgccatcc aggcgctcaa gctcaagcac ggcaaggaat acttcgtgcc gtcaatgtcg      660

gcccgtaccg tggtgtacaa gggcctgctg ctggccaacc aggttggcga gtactacctg      720

gacctgctgg accagcgcgc cgtctcggcc ctggccctgg tgcaccagcg cttctcgacc      780

aacaccttcc cggcctggga actggcccac ccgtaccgca tggtcgccca caacggcgaa      840

atcaacacgg tcaagggcaa tgtcaactgg atcaacgcgc gcaccggcgc gatctcgtcg      900

ccggtgctcg gcgacgacct gcccaagctg tggccgctga tctacccggg ccagtccgac      960

accgcatcgt tcgacaactg cctcgaactg ctgacgatgg ccggctaccc gctcgtccac     1020

gcgatgatga tgatgatccc ggaagcctgg gaacagcaca cgctgatgga cgacaaccgc     1080

cgcgccttct acgagtacca cgccgccatg atggagccgt gggacggccc ggccgcgatc     1140

tgcttcaccg atggccgcca gatcggcgcc acgctggacc gcaacggcct gcgcccggca     1200

cgtttctacg tgaccgagga cgacatcgtg gtgctggctt cggaagccgg cgtgctgccg     1260

ttccccgagt cgcgcatcgt tgagaagtgg cgcctgcagc cgggcaagat gttcctgatc     1320

gacatggaac agggccgcat catcgacgac aaggaactca aggacaacct ggccaacgcc     1380

aagccgtaca agagctggat cgacgccgtg cgcatcaagc tcgacgagct cgacgccaag     1440

cctgaagacg ttgccgccga gaagaagccc gtggccaagc tgctggaccg ccagcaggcc     1500

tttggctaca cccaggaaga cgtcaagttc ctgatggcgc cgatggcgct ggccggcgag     1560

gaagccaccg gctcgatggg caacgattcg ccgctggcca tcctgtcgtc caagaacaag     1620

acgctgtacc actacttcaa gcagctgttc gcccaggtca ccaacccgcc gatcgacccg     1680

atccgcgaga acatggtgat gtcgctggtg tcgttcatcg gcccgaagcc gaacctgctc     1740

gagctgaaca acatcaaccc gccgatgcgc ctcgaagtgt cccagccggt gctggacttc     1800

aaggacatcg ccaagatccg caatatcgag cactacaccg gcggcaagtt ccgttcgtac     1860

gagctgaaca tctgctaccc gaaggcctgg ggcaaggagg gcatcgaagc gcgcctggcc     1920

tcgctgtgcg ccgaagccgt ggatgcggtg cgttcgggct tcaacatcct gatcgtgtcg     1980

gaccgccgcg tggatgccga gcatgttgcg attcccgcgc tgctggccac gtccgccatc     2040

caccaccacc tggtggagaa gggcctgcgc acgtccaccg gcctggtggt cgagaccggc     2100

accgcccgtg aagtgcacca cttcgcgctg ctggccggct atggcgccga agccgtgcat     2160

ccgtacctgg cgatggaaac gctggccgaa atggcccagg gcctgtccgg cgacctgtcg     2220

cccgagaagg cggtcaagaa cttcgtcaag gcgatcggca agggcctgtt caaagtgatg     2280

tccaagatgg gcatctccac ctacatgtcg tacaccggcg cgcagatctt cgaagccatc     2340

ggcctgtcgc gcgaactggt gcagaagtac ttccatggca ccccgtcgaa tgtcgagggc     2400

atcggcatct tcgaagtggc cgaggaagcc ctgcgcctgc accgcgacgc ctttggcgac     2460

aacccggtgc tggaaagcat gctggacgcc ggcggcgaat acgccttccg catccgcggc     2520

gaagagcata tgtggacccc ggactcggtc gccaagctgc agcactcggt gcgcgccgac     2580

gacggcaagg gcgcctacca gacgtacaag gaatacgcca acatcatcaa cgaccagagc     2640

aagcgccaca tgacgctgcg tggcctgttc gagttcaagg tcgatccggc caaggcgatt     2700

ccgctggaag aggtggagtc ggccaaggag atcgtcaagc gcttcgccac cggtgcgatg     2760

tcgctcggct cgatctcgac cgaagcccac accacgctgg cgctggcgat gaaccgcatc     2820

ggcggcaagt ccaacaccgg cgaaggcggc gaggacgaga agcgctaccg caacgagctg     2880

cgcggcattc ccatcaagca gggcgatacc ctcaagggcc tgctgggcga caacgtgatc     2940

gaacgcgacc tggaactgca ggaaggcgat tcgctgcgct cgaagatcaa gcaggtggcg     3000

tcgggccgtt tcggcgtgac cgccgaatac ctggcttcgg ccgaccagat ccagatcaag     3060

atggcgcagg gtgccaagcc cggcgaaggc ggccagctgc ccggccacaa ggtctcggac     3120

tacatcggca agctgcgtta ctcggtgccg ggcgtgggcc tgatctcgcc gcccccgcac     3180

catgacatct attcgatcga ggatctggca cagctgatcc acgacctgaa gaacgtcaac     3240

ccggtgtcgg acatctcggt caagctggtg tccgaagtcg gcgtcggcac ggtggccgcg     3300

ggcgtggcca aggccaaggc cgaccacgtc gtgatcgccg gccatgatgg cggcaccggc     3360

gcttcgccgt ggtcgtcgat caagcatgcc ggcacgccgt gggagctggg cctggccgaa     3420

acgcagcaga cgctgctgct caacggcctg cgcaaccgca tccgcgtgca ggccgacggc     3480

cagatgaaga ccggccgcga cgtcgtcatc ggcgcgctgc tgggcgccga tgaattcggc     3540

ttcgccaccg cgccgctggt tgcggaaggc tgcatcatga tgcgcaagtg ccacctgaac     3600

acctgcccgg tgggcgtggc cacgcaggat ccgcagctgc gcaggaagtt ccagggcaag     3660

cctgagcacg tggtcaactt cttcttcttc gttgcggaag aagcccgcga aatcatggcc     3720

cagctgggca tccgcaagtt cgacgagctg atcggccgcg ccgacctgct cgacaccaag     3780

cccggcatcg agcactggaa ggcgcgcggc ctggacttcg gccgcatctt ccaccaggtc     3840

tcgctgggcg cggacgtgcc gctgtaccac accgacgtgc aggaccacgg cctgtcggcc     3900

gaggccggca aggcgctgga ccacgtgctg atcgccaagg cccgaccggc gatcgagaag     3960

ggcgagcggg tctcgttcat ccagccggtg aagaacgtca accgtaccgt cggcgcgatg     4020

ctgtcgggcg tggtggcgcg ccagcatggc cacgaaggcc tgcctgacga taccatccac     4080

atccagctgc aaggcaccgc cggccagtcg ttcggcgcgt tcctggcgca cggcatcacg     4140

ctggacctgg tgggcgacgg caacgactat gtcggcaagg gcctgtcggg cggccgcgtg     4200

atcgtgcgcg ctccgcatga gttccgcggc gacccgaccc gcaacatcat cgtcggcaac     4260

accgtgctgt acggtgctat cgccggggaa gcgttcttca acggcgtggc cggcgagcgc     4320

ttcgcggtgc gcaactcggg tgcggtggca gtggtggaag gcaccggcga ccacggttgc     4380

gagtacatga ccggcggcac ggtggtggtg ctgggcggca ccggacgcaa cttcgcggcc     4440

ggcatgtcgg gcggcgtggc ctacgtctac gacgaggacg gcctgttcga caagcgctgc     4500

aacacctcga tggtggcgct ggaagcagtg ctggcttcgg ccgaccagga gaagggccag     4560

cccgaggctt cgtggcacaa ggtcgacggc aagcgccagc tggatgaggt catcctgcgc     4620

aacctgatcg agcagcattt ccgctacacc ggttccgagc gcgccaaggc gctgctggcc     4680

gactggacca cggcacgccg caagttcgtc aaggtcttcc cgaccgagta caagcgcgcg     4740

ctgggcgaga tgtacgccaa ggaacaggcc gcccgcgaca gcgaccgcga agccatcgcg     4800

gcctga                                                                4806


<210>  50
<211>  1601
<212>  PRT
<213>  C. necator

<400>  50

Met Asp Gln Thr Lys Asn Leu Ser Ala Gln Ala Gln Ala Gln Ala Gln 
1               5                   10                  15      


Thr Ser Glu Ser Ser His Ala Ile Asp Leu Arg Pro Gln Ala Gln Gly 
            20                  25                  30          


Met Tyr Asp Pro Ser Asn Glu His Asp Ala Cys Gly Val Gly Met Val 
        35                  40                  45              


Ala His Ile Lys Gly Lys Lys Ser His Glu Ile Ile Ser Gln Gly Leu 
    50                  55                  60                  


Lys Ile Leu Glu Asn Leu Asp His Arg Gly Ala Val Gly Ala Asp Ala 
65                  70                  75                  80  


Leu Met Gly Asp Gly Ala Gly Ile Leu Ile Gln Ile Pro Asp Gln Phe 
                85                  90                  95      


Tyr Arg Glu Glu Met Ala Ala Gln Gly Val Ser Leu Pro Pro Ala Gly 
            100                 105                 110         


Glu Tyr Gly Val Gly Met Ile Phe Leu Pro Lys Glu His Ala Ser Arg 
        115                 120                 125             


Leu Ala Cys Glu Gln Glu Leu Glu Arg Thr Val Arg Leu Glu Gly Gln 
    130                 135                 140                 


Val Val Leu Gly Trp Arg Asp Val Pro Val Asp Ala Lys Met Pro Met 
145                 150                 155                 160 


Ser Pro Thr Val Arg Thr Thr Glu Pro Val Ile Arg Gln Ile Phe Ile 
                165                 170                 175     


Gly Arg Gly Arg Asp Ile Met Thr Thr Asp Ala Leu Glu Arg Lys Leu 
            180                 185                 190         


Tyr Val Ile Arg Lys Thr Ala Ser His Ala Ile Gln Ala Leu Lys Leu 
        195                 200                 205             


Lys His Gly Lys Glu Tyr Phe Val Pro Ser Met Ser Ala Arg Thr Val 
    210                 215                 220                 


Val Tyr Lys Gly Leu Leu Leu Ala Asn Gln Val Gly Glu Tyr Tyr Leu 
225                 230                 235                 240 


Asp Leu Leu Asp Gln Arg Ala Val Ser Ala Leu Ala Leu Val His Gln 
                245                 250                 255     


Arg Phe Ser Thr Asn Thr Phe Pro Ala Trp Glu Leu Ala His Pro Tyr 
            260                 265                 270         


Arg Met Val Ala His Asn Gly Glu Ile Asn Thr Val Lys Gly Asn Val 
        275                 280                 285             


Asn Trp Ile Asn Ala Arg Thr Gly Ala Ile Ser Ser Pro Val Leu Gly 
    290                 295                 300                 


Asp Asp Leu Pro Lys Leu Trp Pro Leu Ile Tyr Pro Gly Gln Ser Asp 
305                 310                 315                 320 


Thr Ala Ser Phe Asp Asn Cys Leu Glu Leu Leu Thr Met Ala Gly Tyr 
                325                 330                 335     


Pro Leu Val His Ala Met Met Met Met Ile Pro Glu Ala Trp Glu Gln 
            340                 345                 350         


His Thr Leu Met Asp Asp Asn Arg Arg Ala Phe Tyr Glu Tyr His Ala 
        355                 360                 365             


Ala Met Met Glu Pro Trp Asp Gly Pro Ala Ala Ile Cys Phe Thr Asp 
    370                 375                 380                 


Gly Arg Gln Ile Gly Ala Thr Leu Asp Arg Asn Gly Leu Arg Pro Ala 
385                 390                 395                 400 


Arg Phe Tyr Val Thr Glu Asp Asp Ile Val Val Leu Ala Ser Glu Ala 
                405                 410                 415     


Gly Val Leu Pro Phe Pro Glu Ser Arg Ile Val Glu Lys Trp Arg Leu 
            420                 425                 430         


Gln Pro Gly Lys Met Phe Leu Ile Asp Met Glu Gln Gly Arg Ile Ile 
        435                 440                 445             


Asp Asp Lys Glu Leu Lys Asp Asn Leu Ala Asn Ala Lys Pro Tyr Lys 
    450                 455                 460                 


Ser Trp Ile Asp Ala Val Arg Ile Lys Leu Asp Glu Leu Asp Ala Lys 
465                 470                 475                 480 


Pro Glu Asp Val Ala Ala Glu Lys Lys Pro Val Ala Lys Leu Leu Asp 
                485                 490                 495     


Arg Gln Gln Ala Phe Gly Tyr Thr Gln Glu Asp Val Lys Phe Leu Met 
            500                 505                 510         


Ala Pro Met Ala Leu Ala Gly Glu Glu Ala Thr Gly Ser Met Gly Asn 
        515                 520                 525             


Asp Ser Pro Leu Ala Ile Leu Ser Ser Lys Asn Lys Thr Leu Tyr His 
    530                 535                 540                 


Tyr Phe Lys Gln Leu Phe Ala Gln Val Thr Asn Pro Pro Ile Asp Pro 
545                 550                 555                 560 


Ile Arg Glu Asn Met Val Met Ser Leu Val Ser Phe Ile Gly Pro Lys 
                565                 570                 575     


Pro Asn Leu Leu Glu Leu Asn Asn Ile Asn Pro Pro Met Arg Leu Glu 
            580                 585                 590         


Val Ser Gln Pro Val Leu Asp Phe Lys Asp Ile Ala Lys Ile Arg Asn 
        595                 600                 605             


Ile Glu His Tyr Thr Gly Gly Lys Phe Arg Ser Tyr Glu Leu Asn Ile 
    610                 615                 620                 


Cys Tyr Pro Lys Ala Trp Gly Lys Glu Gly Ile Glu Ala Arg Leu Ala 
625                 630                 635                 640 


Ser Leu Cys Ala Glu Ala Val Asp Ala Val Arg Ser Gly Phe Asn Ile 
                645                 650                 655     


Leu Ile Val Ser Asp Arg Arg Val Asp Ala Glu His Val Ala Ile Pro 
            660                 665                 670         


Ala Leu Leu Ala Thr Ser Ala Ile His His His Leu Val Glu Lys Gly 
        675                 680                 685             


Leu Arg Thr Ser Thr Gly Leu Val Val Glu Thr Gly Thr Ala Arg Glu 
    690                 695                 700                 


Val His His Phe Ala Leu Leu Ala Gly Tyr Gly Ala Glu Ala Val His 
705                 710                 715                 720 


Pro Tyr Leu Ala Met Glu Thr Leu Ala Glu Met Ala Gln Gly Leu Ser 
                725                 730                 735     


Gly Asp Leu Ser Pro Glu Lys Ala Val Lys Asn Phe Val Lys Ala Ile 
            740                 745                 750         


Gly Lys Gly Leu Phe Lys Val Met Ser Lys Met Gly Ile Ser Thr Tyr 
        755                 760                 765             


Met Ser Tyr Thr Gly Ala Gln Ile Phe Glu Ala Ile Gly Leu Ser Arg 
    770                 775                 780                 


Glu Leu Val Gln Lys Tyr Phe His Gly Thr Pro Ser Asn Val Glu Gly 
785                 790                 795                 800 


Ile Gly Ile Phe Glu Val Ala Glu Glu Ala Leu Arg Leu His Arg Asp 
                805                 810                 815     


Ala Phe Gly Asp Asn Pro Val Leu Glu Ser Met Leu Asp Ala Gly Gly 
            820                 825                 830         


Glu Tyr Ala Phe Arg Ile Arg Gly Glu Glu His Met Trp Thr Pro Asp 
        835                 840                 845             


Ser Val Ala Lys Leu Gln His Ser Val Arg Ala Asp Asp Gly Lys Gly 
    850                 855                 860                 


Ala Tyr Gln Thr Tyr Lys Glu Tyr Ala Asn Ile Ile Asn Asp Gln Ser 
865                 870                 875                 880 


Lys Arg His Met Thr Leu Arg Gly Leu Phe Glu Phe Lys Val Asp Pro 
                885                 890                 895     


Ala Lys Ala Ile Pro Leu Glu Glu Val Glu Ser Ala Lys Glu Ile Val 
            900                 905                 910         


Lys Arg Phe Ala Thr Gly Ala Met Ser Leu Gly Ser Ile Ser Thr Glu 
        915                 920                 925             


Ala His Thr Thr Leu Ala Leu Ala Met Asn Arg Ile Gly Gly Lys Ser 
    930                 935                 940                 


Asn Thr Gly Glu Gly Gly Glu Asp Glu Lys Arg Tyr Arg Asn Glu Leu 
945                 950                 955                 960 


Arg Gly Ile Pro Ile Lys Gln Gly Asp Thr Leu Lys Gly Leu Leu Gly 
                965                 970                 975     


Asp Asn Val Ile Glu Arg Asp Leu Glu Leu Gln Glu Gly Asp Ser Leu 
            980                 985                 990         


Arg Ser Lys Ile Lys Gln Val Ala  Ser Gly Arg Phe Gly  Val Thr Ala 
        995                 1000                 1005             


Glu Tyr  Leu Ala Ser Ala Asp  Gln Ile Gln Ile Lys  Met Ala Gln 
    1010                 1015                 1020             


Gly Ala  Lys Pro Gly Glu Gly  Gly Gln Leu Pro Gly  His Lys Val 
    1025                 1030                 1035             


Ser Asp  Tyr Ile Gly Lys Leu  Arg Tyr Ser Val Pro  Gly Val Gly 
    1040                 1045                 1050             


Leu Ile  Ser Pro Pro Pro His  His Asp Ile Tyr Ser  Ile Glu Asp 
    1055                 1060                 1065             


Leu Ala  Gln Leu Ile His Asp  Leu Lys Asn Val Asn  Pro Val Ser 
    1070                 1075                 1080             


Asp Ile  Ser Val Lys Leu Val  Ser Glu Val Gly Val  Gly Thr Val 
    1085                 1090                 1095             


Ala Ala  Gly Val Ala Lys Ala  Lys Ala Asp His Val  Val Ile Ala 
    1100                 1105                 1110             


Gly His  Asp Gly Gly Thr Gly  Ala Ser Pro Trp Ser  Ser Ile Lys 
    1115                 1120                 1125             


His Ala  Gly Thr Pro Trp Glu  Leu Gly Leu Ala Glu  Thr Gln Gln 
    1130                 1135                 1140             


Thr Leu  Leu Leu Asn Gly Leu  Arg Asn Arg Ile Arg  Val Gln Ala 
    1145                 1150                 1155             


Asp Gly  Gln Met Lys Thr Gly  Arg Asp Val Val Ile  Gly Ala Leu 
    1160                 1165                 1170             


Leu Gly  Ala Asp Glu Phe Gly  Phe Ala Thr Ala Pro  Leu Val Ala 
    1175                 1180                 1185             


Glu Gly  Cys Ile Met Met Arg  Lys Cys His Leu Asn  Thr Cys Pro 
    1190                 1195                 1200             


Val Gly  Val Ala Thr Gln Asp  Pro Gln Leu Arg Arg  Lys Phe Gln 
    1205                 1210                 1215             


Gly Lys  Pro Glu His Val Val  Asn Phe Phe Phe Phe  Val Ala Glu 
    1220                 1225                 1230             


Glu Ala  Arg Glu Ile Met Ala  Gln Leu Gly Ile Arg  Lys Phe Asp 
    1235                 1240                 1245             


Glu Leu  Ile Gly Arg Ala Asp  Leu Leu Asp Thr Lys  Pro Gly Ile 
    1250                 1255                 1260             


Glu His  Trp Lys Ala Arg Gly  Leu Asp Phe Gly Arg  Ile Phe His 
    1265                 1270                 1275             


Gln Val  Ser Leu Gly Ala Asp  Val Pro Leu Tyr His  Thr Asp Val 
    1280                 1285                 1290             


Gln Asp  His Gly Leu Ser Ala  Glu Ala Gly Lys Ala  Leu Asp His 
    1295                 1300                 1305             


Val Leu  Ile Ala Lys Ala Arg  Pro Ala Ile Glu Lys  Gly Glu Arg 
    1310                 1315                 1320             


Val Ser  Phe Ile Gln Pro Val  Lys Asn Val Asn Arg  Thr Val Gly 
    1325                 1330                 1335             


Ala Met  Leu Ser Gly Val Val  Ala Arg Gln His Gly  His Glu Gly 
    1340                 1345                 1350             


Leu Pro  Asp Asp Thr Ile His  Ile Gln Leu Gln Gly  Thr Ala Gly 
    1355                 1360                 1365             


Gln Ser  Phe Gly Ala Phe Leu  Ala His Gly Ile Thr  Leu Asp Leu 
    1370                 1375                 1380             


Val Gly  Asp Gly Asn Asp Tyr  Val Gly Lys Gly Leu  Ser Gly Gly 
    1385                 1390                 1395             


Arg Val  Ile Val Arg Ala Pro  His Glu Phe Arg Gly  Asp Pro Thr 
    1400                 1405                 1410             


Arg Asn  Ile Ile Val Gly Asn  Thr Val Leu Tyr Gly  Ala Ile Ala 
    1415                 1420                 1425             


Gly Glu  Ala Phe Phe Asn Gly  Val Ala Gly Glu Arg  Phe Ala Val 
    1430                 1435                 1440             


Arg Asn  Ser Gly Ala Val Ala  Val Val Glu Gly Thr  Gly Asp His 
    1445                 1450                 1455             


Gly Cys  Glu Tyr Met Thr Gly  Gly Thr Val Val Val  Leu Gly Gly 
    1460                 1465                 1470             


Thr Gly  Arg Asn Phe Ala Ala  Gly Met Ser Gly Gly  Val Ala Tyr 
    1475                 1480                 1485             


Val Tyr  Asp Glu Asp Gly Leu  Phe Asp Lys Arg Cys  Asn Thr Ser 
    1490                 1495                 1500             


Met Val  Ala Leu Glu Ala Val  Leu Ala Ser Ala Asp  Gln Glu Lys 
    1505                 1510                 1515             


Gly Gln  Pro Glu Ala Ser Trp  His Lys Val Asp Gly  Lys Arg Gln 
    1520                 1525                 1530             


Leu Asp  Glu Val Ile Leu Arg  Asn Leu Ile Glu Gln  His Phe Arg 
    1535                 1540                 1545             


Tyr Thr  Gly Ser Glu Arg Ala  Lys Ala Leu Leu Ala  Asp Trp Thr 
    1550                 1555                 1560             


Thr Ala  Arg Arg Lys Phe Val  Lys Val Phe Pro Thr  Glu Tyr Lys 
    1565                 1570                 1575             


Arg Ala  Leu Gly Glu Met Tyr  Ala Lys Glu Gln Ala  Ala Arg Asp 
    1580                 1585                 1590             


Ser Asp  Arg Glu Ala Ile Ala  Ala 
    1595                 1600     


<210>  51
<211>  975
<212>  DNA
<213>  C. necator

<400>  51
atgaagaccg gcaaaagctc ggcaggagac accaaggccc ggattctcga cgccacggaa       60

aagttgttta ccgaggtcgg ctatgaagcc acctcgctca ggcaggtcac gtcgcgcgcc      120

atcgtcaacc tggccgccgt gaactaccac ttccgcagca aagatatcat gatgcacgcc      180

gtgctgagcc ggcggctgga tccgctcaac gcgcggcgcc tggcgctgct cgatgcgtgc      240

gaagcgcgct ggcccggcaa cagcatccgc tgcgagcacg tgatgggtgc gctgttcgtg      300

cccgcgctgc aaatggcacg cgacccgtcg gtgggcgggc cgtcgttcct gcggctgctc      360

gggcgcgtgt attcggatac ctcgcccttt atccagcaat acctgctgga gcactacgcc      420

ccggtgtacg ggcgcttctt cgacgccttc tcgcgcgcca ttccggcgct gccgcggcat      480

gagctcggct ggcgcctgca gtttgcgctc aaggcgctgg ccggcgtgct ggccggcgaa      540

gagctcacca acctgctgcc cgcgttcacg cagggccggc agatgagcga tgcgcacgtg      600

ctggcccagc tcaccgccat ggtggaagcc gtgctgaacg tggcgcaacc cagtgcggac      660

gacttctcgg ccctgcagtc ggtgttcgag cttggcgagc agcagcaggc cagggagcgc      720

gccagcaggc tggccgcggc gcggtctgcc gatgaactga gtgccagttg cgccgcgatg      780

gcggcaacca tgggcgatgc ggccagccag accgccgccg ccctcggcaa ggcccgcatc      840

agcgcacgca ccgtgcgcaa tgagggcacc aaacgctcag ccgtgaccag catgccggtc      900

cgcgcgcgcg agcaaaccgt gagcttcccc agcaacccgc tggatgactg gatgcgaatg      960

cgcaccagga catag                                                       975


<210>  52
<211>  324
<212>  PRT
<213>  C. necator

<400>  52

Met Lys Thr Gly Lys Ser Ser Ala Gly Asp Thr Lys Ala Arg Ile Leu 
1               5                   10                  15      


Asp Ala Thr Glu Lys Leu Phe Thr Glu Val Gly Tyr Glu Ala Thr Ser 
            20                  25                  30          


Leu Arg Gln Val Thr Ser Arg Ala Ile Val Asn Leu Ala Ala Val Asn 
        35                  40                  45              


Tyr His Phe Arg Ser Lys Asp Ile Met Met His Ala Val Leu Ser Arg 
    50                  55                  60                  


Arg Leu Asp Pro Leu Asn Ala Arg Arg Leu Ala Leu Leu Asp Ala Cys 
65                  70                  75                  80  


Glu Ala Arg Trp Pro Gly Asn Ser Ile Arg Cys Glu His Val Met Gly 
                85                  90                  95      


Ala Leu Phe Val Pro Ala Leu Gln Met Ala Arg Asp Pro Ser Val Gly 
            100                 105                 110         


Gly Pro Ser Phe Leu Arg Leu Leu Gly Arg Val Tyr Ser Asp Thr Ser 
        115                 120                 125             


Pro Phe Ile Gln Gln Tyr Leu Leu Glu His Tyr Ala Pro Val Tyr Gly 
    130                 135                 140                 


Arg Phe Phe Asp Ala Phe Ser Arg Ala Ile Pro Ala Leu Pro Arg His 
145                 150                 155                 160 


Glu Leu Gly Trp Arg Leu Gln Phe Ala Leu Lys Ala Leu Ala Gly Val 
                165                 170                 175     


Leu Ala Gly Glu Glu Leu Thr Asn Leu Leu Pro Ala Phe Thr Gln Gly 
            180                 185                 190         


Arg Gln Met Ser Asp Ala His Val Leu Ala Gln Leu Thr Ala Met Val 
        195                 200                 205             


Glu Ala Val Leu Asn Val Ala Gln Pro Ser Ala Asp Asp Phe Ser Ala 
    210                 215                 220                 


Leu Gln Ser Val Phe Glu Leu Gly Glu Gln Gln Gln Ala Arg Glu Arg 
225                 230                 235                 240 


Ala Ser Arg Leu Ala Ala Ala Arg Ser Ala Asp Glu Leu Ser Ala Ser 
                245                 250                 255     


Cys Ala Ala Met Ala Ala Thr Met Gly Asp Ala Ala Ser Gln Thr Ala 
            260                 265                 270         


Ala Ala Leu Gly Lys Ala Arg Ile Ser Ala Arg Thr Val Arg Asn Glu 
        275                 280                 285             


Gly Thr Lys Arg Ser Ala Val Thr Ser Met Pro Val Arg Ala Arg Glu 
    290                 295                 300                 


Gln Thr Val Ser Phe Pro Ser Asn Pro Leu Asp Asp Trp Met Arg Met 
305                 310                 315                 320 


Arg Thr Arg Thr 
                


<210>  53
<211>  672
<212>  DNA
<213>  C. necator

<400>  53
atgcgccgga tcgagaccgc gctgctcgac ggcacctggc cgcccggcac gcggctgccg       60

gccgagcggg tgctggccgg gcaatacgag gtggcgcgca acaccgtgcg cgaggcgatc      120

cagcgcctgg ccgcgcgcgg cctgctgcag agccggcgcg gtgccggggt ctacgccacc      180

gaccagctgc gcgccggcat tgcctcgccc tggggccagc tggtggccga ccaccccgcg      240

ctgcgcgacg acatcctgga gttccgccgc gtgctggagg gcgcgaccgc gtattttgcg      300

gcgctgcgcg cggatgccgc tgacgtgaag cggatccgcg ccctgatggc cgagctggaa      360

cgcgcgcgcg ccgccgacga caagcaggca gaggccgatg ccgatgcgca gctgcacgac      420

gccattgccc aggcctcgca caacaccatg ttcctgcacc tgcataccag cgtgatcggc      480

atgctgcgcg agcacatcac catcaatggc accggcctgc gcgaacagga cgacggcgcg      540

tcagacctgt tgctgctgca gcatcgcacg ctgtgcgatg cgatttgcgc gcgccgcccg      600

gaagaggcgc gcaccgccat gcagacccat atcgacttcg tgcgcagccg ggtggagcag      660

gacggcgcct ga                                                          672


<210>  54
<211>  223
<212>  PRT
<213>  C. necator

<400>  54

Met Arg Arg Ile Glu Thr Ala Leu Leu Asp Gly Thr Trp Pro Pro Gly 
1               5                   10                  15      


Thr Arg Leu Pro Ala Glu Arg Val Leu Ala Gly Gln Tyr Glu Val Ala 
            20                  25                  30          


Arg Asn Thr Val Arg Glu Ala Ile Gln Arg Leu Ala Ala Arg Gly Leu 
        35                  40                  45              


Leu Gln Ser Arg Arg Gly Ala Gly Val Tyr Ala Thr Asp Gln Leu Arg 
    50                  55                  60                  


Ala Gly Ile Ala Ser Pro Trp Gly Gln Leu Val Ala Asp His Pro Ala 
65                  70                  75                  80  


Leu Arg Asp Asp Ile Leu Glu Phe Arg Arg Val Leu Glu Gly Ala Thr 
                85                  90                  95      


Ala Tyr Phe Ala Ala Leu Arg Ala Asp Ala Ala Asp Val Lys Arg Ile 
            100                 105                 110         


Arg Ala Leu Met Ala Glu Leu Glu Arg Ala Arg Ala Ala Asp Asp Lys 
        115                 120                 125             


Gln Ala Glu Ala Asp Ala Asp Ala Gln Leu His Asp Ala Ile Ala Gln 
    130                 135                 140                 


Ala Ser His Asn Thr Met Phe Leu His Leu His Thr Ser Val Ile Gly 
145                 150                 155                 160 


Met Leu Arg Glu His Ile Thr Ile Asn Gly Thr Gly Leu Arg Glu Gln 
                165                 170                 175     


Asp Asp Gly Ala Ser Asp Leu Leu Leu Leu Gln His Arg Thr Leu Cys 
            180                 185                 190         


Asp Ala Ile Cys Ala Arg Arg Pro Glu Glu Ala Arg Thr Ala Met Gln 
        195                 200                 205             


Thr His Ile Asp Phe Val Arg Ser Arg Val Glu Gln Asp Gly Ala 
    210                 215                 220             


<210>  55
<211>  1476
<212>  DNA
<213>  C. necator

<400>  55
atgggcatgg tctcaataga acccggcagc tatcacgttg taccgccgca aaaccccggc       60

gaggtcatcg atctgatccg gacgcacgcg atccaggtgg ttgacctcag gttcaccgac      120

ttgcccggcg tgtggcagca cttctcgatc acgctgccgg aagtcaacga cgacttattc      180

tctgtcggca tcggcttcga cgggtcttcc attcgcgggt tccaggaaat ccacgagtcc      240

gacatgctgg tcaggcctga cccggccacg gcgttcatcg atccgtattg cgcagcacca      300

acgctggcgc tgatctgcga cgtgctggac cctgtcctgc accagccgta ctcgcgcgat      360

ccgcgccata tcgcacgcaa ggccgagctg tacctccggc aaaccggtct tgccacggtt      420

tgctaccttg gccccgaact ggaattcttt attttcgact ccatacgctt cgggcaggac      480

cagcactctg gctactacca tgtcgaatcc gccgaaggcg aatggacctc gggccgtgac      540

gaaggcgcct atggcggggg caatctcggc tacaaacagc gctacaaggg cgggtacttt      600

cccgtgccgc caagcgacac gctgcaggac atccgctccg aaatcgtgct cgcgctgatg      660

caggccggca tccaggtcga agtgcatcac catgaggtcg ccacggccgg ccagaatgaa      720

atcgacatgc gctttgcgcc actgatgcgc atggcagaca acgtgatgat gtacaagtac      780

atctgcaaga acgttgcgcg ccgccacggc aaggtcgcca ccttcatgcc caagccgctg      840

tttgccgaca acgcgagcgg catgcattgc caccagagcc tctggcgcga cgccgagaac      900

ctcttctatg acaagaacgg ttgggcgcag acgtcccaga tgtgccgttg gtatataggc      960

ggcttgctca gccacgcccc cgcgctgatg gcattctgcg caccgagcac gaactcctac     1020

aagcggctgg tgcccggata cgaggcgcct gtcaatctgg ccatgtcgca gcgcaaccgg     1080

tccgccgcgg cccggattcc aatggtttcg gattccccga gcgccaggcg cgttgaattt     1140

cgctgtcctg atccgtcggc caatgcctac ctcgccttct cggcaatgct gctcgccggc     1200

ctggacggca ttgaaaacca gacggacccc ggcgacccgc tcgacaagaa catctatgat     1260

ctgccaccgg aggaagccgc ccgcatccgg caggtaccag gctccctgga agagtcgctt     1320

tgcgcgctgg aagccgattc agcgttcctg cgcaaggggg atgtcttcac tgaagacctg     1380

atcacgacct ggattgatta caagcgcacg cgcgagatcg atacattgaa ggtgcggcca     1440

cacccgtggg aattccagct ctacttcgac atctga                               1476


<210>  56
<211>  491
<212>  PRT
<213>  C. necator

<400>  56

Met Gly Met Val Ser Ile Glu Pro Gly Ser Tyr His Val Val Pro Pro 
1               5                   10                  15      


Gln Asn Pro Gly Glu Val Ile Asp Leu Ile Arg Thr His Ala Ile Gln 
            20                  25                  30          


Val Val Asp Leu Arg Phe Thr Asp Leu Pro Gly Val Trp Gln His Phe 
        35                  40                  45              


Ser Ile Thr Leu Pro Glu Val Asn Asp Asp Leu Phe Ser Val Gly Ile 
    50                  55                  60                  


Gly Phe Asp Gly Ser Ser Ile Arg Gly Phe Gln Glu Ile His Glu Ser 
65                  70                  75                  80  


Asp Met Leu Val Arg Pro Asp Pro Ala Thr Ala Phe Ile Asp Pro Tyr 
                85                  90                  95      


Cys Ala Ala Pro Thr Leu Ala Leu Ile Cys Asp Val Leu Asp Pro Val 
            100                 105                 110         


Leu His Gln Pro Tyr Ser Arg Asp Pro Arg His Ile Ala Arg Lys Ala 
        115                 120                 125             


Glu Leu Tyr Leu Arg Gln Thr Gly Leu Ala Thr Val Cys Tyr Leu Gly 
    130                 135                 140                 


Pro Glu Leu Glu Phe Phe Ile Phe Asp Ser Ile Arg Phe Gly Gln Asp 
145                 150                 155                 160 


Gln His Ser Gly Tyr Tyr His Val Glu Ser Ala Glu Gly Glu Trp Thr 
                165                 170                 175     


Ser Gly Arg Asp Glu Gly Ala Tyr Gly Gly Gly Asn Leu Gly Tyr Lys 
            180                 185                 190         


Gln Arg Tyr Lys Gly Gly Tyr Phe Pro Val Pro Pro Ser Asp Thr Leu 
        195                 200                 205             


Gln Asp Ile Arg Ser Glu Ile Val Leu Ala Leu Met Gln Ala Gly Ile 
    210                 215                 220                 


Gln Val Glu Val His His His Glu Val Ala Thr Ala Gly Gln Asn Glu 
225                 230                 235                 240 


Ile Asp Met Arg Phe Ala Pro Leu Met Arg Met Ala Asp Asn Val Met 
                245                 250                 255     


Met Tyr Lys Tyr Ile Cys Lys Asn Val Ala Arg Arg His Gly Lys Val 
            260                 265                 270         


Ala Thr Phe Met Pro Lys Pro Leu Phe Ala Asp Asn Ala Ser Gly Met 
        275                 280                 285             


His Cys His Gln Ser Leu Trp Arg Asp Ala Glu Asn Leu Phe Tyr Asp 
    290                 295                 300                 


Lys Asn Gly Trp Ala Gln Thr Ser Gln Met Cys Arg Trp Tyr Ile Gly 
305                 310                 315                 320 


Gly Leu Leu Ser His Ala Pro Ala Leu Met Ala Phe Cys Ala Pro Ser 
                325                 330                 335     


Thr Asn Ser Tyr Lys Arg Leu Val Pro Gly Tyr Glu Ala Pro Val Asn 
            340                 345                 350         


Leu Ala Met Ser Gln Arg Asn Arg Ser Ala Ala Ala Arg Ile Pro Met 
        355                 360                 365             


Val Ser Asp Ser Pro Ser Ala Arg Arg Val Glu Phe Arg Cys Pro Asp 
    370                 375                 380                 


Pro Ser Ala Asn Ala Tyr Leu Ala Phe Ser Ala Met Leu Leu Ala Gly 
385                 390                 395                 400 


Leu Asp Gly Ile Glu Asn Gln Thr Asp Pro Gly Asp Pro Leu Asp Lys 
                405                 410                 415     


Asn Ile Tyr Asp Leu Pro Pro Glu Glu Ala Ala Arg Ile Arg Gln Val 
            420                 425                 430         


Pro Gly Ser Leu Glu Glu Ser Leu Cys Ala Leu Glu Ala Asp Ser Ala 
        435                 440                 445             


Phe Leu Arg Lys Gly Asp Val Phe Thr Glu Asp Leu Ile Thr Thr Trp 
    450                 455                 460                 


Ile Asp Tyr Lys Arg Thr Arg Glu Ile Asp Thr Leu Lys Val Arg Pro 
465                 470                 475                 480 


His Pro Trp Glu Phe Gln Leu Tyr Phe Asp Ile 
                485                 490     


<210>  57
<211>  906
<212>  DNA
<213>  C. necator

<400>  57
atgactgcgc ccttcgacat cctgacccgc atcgccgagc gcggccccgc gctgcgcctg       60

gccgagcaga aggtggcgca ggtggtactg gaagacctgg ccggcgcggc cgccgccagc      120

atcaatgagc tggcgcgcaa ggccggcgtc agcgaggcca gcgtgacgcg ctttgccaag      180

gccatcggct gccgcgacgt gcgcgacctg aagctgcgcc tggcgcaggc caccgcggtg      240

ggtgcgcgct tcctgcagcc cggcagcgtt cccgccggtg aagccacccc ggccacactc      300

gctgacagca tccacgccga catcctcacc gcgctcgaag tcaaccgcgg catgatggat      360

gcgcagcgca tcgaacaggc cgcgcgcctg ttgctcggcg cacgcatggt ctacgctttt      420

ggcatgggcg gcggctcgtc gttcatggcc gacgaggccc gccatcgcct ggcgcgcctg      480

ggccagccgg tggcgagcta ccaggacgcg ctgctacaga agatggtggc ggccacgctg      540

ggccgcgacg acgtggtgct ggccttctcg gccagcggcc gcgtgccgga gatgctggcc      600

agctgcgata tcgcgcgcga gtacggtgcc cgcctggtgg ccgtgaccgc gctgggctcg      660

ccactggccg cgcgcgccga cgtgctgctg ccggtgcgca cgctggagac ggatttcatt      720

ttcaaaccgt cggcatcgcg ctacgccatg ctgatggtgc tggacgtgct cgccacgcaa      780

tgcgcgctgt tgcagccgga ccagagcaaa gagcgcctgc gccggctcaa gtacgtgctg      840

gacagccacc gcggcgaaag cggccccgcc cggggccctg acagccgcca gccgctcgga      900

gactga                                                                 906


<210>  58
<211>  301
<212>  PRT
<213>  C. necator

<400>  58

Met Thr Ala Pro Phe Asp Ile Leu Thr Arg Ile Ala Glu Arg Gly Pro 
1               5                   10                  15      


Ala Leu Arg Leu Ala Glu Gln Lys Val Ala Gln Val Val Leu Glu Asp 
            20                  25                  30          


Leu Ala Gly Ala Ala Ala Ala Ser Ile Asn Glu Leu Ala Arg Lys Ala 
        35                  40                  45              


Gly Val Ser Glu Ala Ser Val Thr Arg Phe Ala Lys Ala Ile Gly Cys 
    50                  55                  60                  


Arg Asp Val Arg Asp Leu Lys Leu Arg Leu Ala Gln Ala Thr Ala Val 
65                  70                  75                  80  


Gly Ala Arg Phe Leu Gln Pro Gly Ser Val Pro Ala Gly Glu Ala Thr 
                85                  90                  95      


Pro Ala Thr Leu Ala Asp Ser Ile His Ala Asp Ile Leu Thr Ala Leu 
            100                 105                 110         


Glu Val Asn Arg Gly Met Met Asp Ala Gln Arg Ile Glu Gln Ala Ala 
        115                 120                 125             


Arg Leu Leu Leu Gly Ala Arg Met Val Tyr Ala Phe Gly Met Gly Gly 
    130                 135                 140                 


Gly Ser Ser Phe Met Ala Asp Glu Ala Arg His Arg Leu Ala Arg Leu 
145                 150                 155                 160 


Gly Gln Pro Val Ala Ser Tyr Gln Asp Ala Leu Leu Gln Lys Met Val 
                165                 170                 175     


Ala Ala Thr Leu Gly Arg Asp Asp Val Val Leu Ala Phe Ser Ala Ser 
            180                 185                 190         


Gly Arg Val Pro Glu Met Leu Ala Ser Cys Asp Ile Ala Arg Glu Tyr 
        195                 200                 205             


Gly Ala Arg Leu Val Ala Val Thr Ala Leu Gly Ser Pro Leu Ala Ala 
    210                 215                 220                 


Arg Ala Asp Val Leu Leu Pro Val Arg Thr Leu Glu Thr Asp Phe Ile 
225                 230                 235                 240 


Phe Lys Pro Ser Ala Ser Arg Tyr Ala Met Leu Met Val Leu Asp Val 
                245                 250                 255     


Leu Ala Thr Gln Cys Ala Leu Leu Gln Pro Asp Gln Ser Lys Glu Arg 
            260                 265                 270         


Leu Arg Arg Leu Lys Tyr Val Leu Asp Ser His Arg Gly Glu Ser Gly 
        275                 280                 285             


Pro Ala Arg Gly Pro Asp Ser Arg Gln Pro Leu Gly Asp 
    290                 295                 300     


<210>  59
<211>  1344
<212>  DNA
<213>  C. necator

<400>  59
gtgaattctc cctcccttga cgcattcctg gcgggggttg cccgccgcga ccccaatcaa       60

cctgaattcc tccaggccgt gaaggaagtg atgatgacgc tctggccctt tgtcgagcgc      120

aatccgcgct acgccgacca ggccctgctc gagcggctgg tggagcccga gcgcgtgatc      180

cagttccgcg tggcctggac cgacgaccag aaccgggtgc aggtcaaccg cgccttccgc      240

gtgcagcaca gctcggccat cggcccgttc aagggcggca tgcgcttcca cccgactgtg      300

aacctgtcgg tgctgaagtt cctgggcttc gagcagacct tcaagaacgc gctgaccacg      360

ctgcccatgg gcggcggcaa gggcggctcg gactttgatc ccaagggcaa gtccgatggc      420

gaagtgatgc gtttctgcca ggcgctggtg accgagctgt tccgccacct gggcccggat      480

accgacatcc cggccggcga catcggcgtg ggcgcacgtg aagtcggctt tatggccggc      540

atgatgaaga agctttccaa ccagtccgcc tgcgtcttca ccggcaaggg cctggcctac      600

ggcggcagcc tgatgcgccc ggaagcgacc ggctacggca cggtctactt tgcgcaggag      660

atgctgcacc ggcgcgggcg cgctttcgac ggcctgcgcg tgctgatctc gggctcgggc      720

aacgtggccc agtacgcggc cgagaaggcg atcgagctgg gcgccacggt gctgacgctg      780

tccgattcag gcggcgtgct gcactacccg cagggcatga ctaccgagca gctggccgaa      840

gtgatggcct tcaagaatga agagcgcggc cgcctgtctg actttgccgc ccgccacggc      900

atggccttcg aagccggccg caccccgtgg cacgtgcccg ccgacgtggc gctgccgtgc      960

gccacccaga acgagctgga cggcaacgac gccgagaccc tgctcggcaa tggcgtgatc     1020

tgcgtggccg aaggcgccaa catgccgtcg acgctggaag ccgtggaccg ctttgtcgat     1080

gcgaagatcc tctacgcccc gggcaaggcc agcaatgccg gcggcgttgc cacttccggc     1140

ctggaaatgt cgcagaacgc catgcgcctg tcctggcacc atgccgaggt cgacgagaag     1200

ctgcacgcga tcatgaagga catccaccag aactgcatcc accacgggca gaaggcggat     1260

ggctatatca actacgtgga aggcgcgaac atcgccggct tcgtcaaggt agccgacgcc     1320

atgctggcgc aaggcgtgat ctga                                            1344


<210>  60
<211>  447
<212>  PRT
<213>  C. necator

<400>  60

Met Asn Ser Pro Ser Leu Asp Ala Phe Leu Ala Gly Val Ala Arg Arg 
1               5                   10                  15      


Asp Pro Asn Gln Pro Glu Phe Leu Gln Ala Val Lys Glu Val Met Met 
            20                  25                  30          


Thr Leu Trp Pro Phe Val Glu Arg Asn Pro Arg Tyr Ala Asp Gln Ala 
        35                  40                  45              


Leu Leu Glu Arg Leu Val Glu Pro Glu Arg Val Ile Gln Phe Arg Val 
    50                  55                  60                  


Ala Trp Thr Asp Asp Gln Asn Arg Val Gln Val Asn Arg Ala Phe Arg 
65                  70                  75                  80  


Val Gln His Ser Ser Ala Ile Gly Pro Phe Lys Gly Gly Met Arg Phe 
                85                  90                  95      


His Pro Thr Val Asn Leu Ser Val Leu Lys Phe Leu Gly Phe Glu Gln 
            100                 105                 110         


Thr Phe Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys Gly 
        115                 120                 125             


Gly Ser Asp Phe Asp Pro Lys Gly Lys Ser Asp Gly Glu Val Met Arg 
    130                 135                 140                 


Phe Cys Gln Ala Leu Val Thr Glu Leu Phe Arg His Leu Gly Pro Asp 
145                 150                 155                 160 


Thr Asp Ile Pro Ala Gly Asp Ile Gly Val Gly Ala Arg Glu Val Gly 
                165                 170                 175     


Phe Met Ala Gly Met Met Lys Lys Leu Ser Asn Gln Ser Ala Cys Val 
            180                 185                 190         


Phe Thr Gly Lys Gly Leu Ala Tyr Gly Gly Ser Leu Met Arg Pro Glu 
        195                 200                 205             


Ala Thr Gly Tyr Gly Thr Val Tyr Phe Ala Gln Glu Met Leu His Arg 
    210                 215                 220                 


Arg Gly Arg Ala Phe Asp Gly Leu Arg Val Leu Ile Ser Gly Ser Gly 
225                 230                 235                 240 


Asn Val Ala Gln Tyr Ala Ala Glu Lys Ala Ile Glu Leu Gly Ala Thr 
                245                 250                 255     


Val Leu Thr Leu Ser Asp Ser Gly Gly Val Leu His Tyr Pro Gln Gly 
            260                 265                 270         


Met Thr Thr Glu Gln Leu Ala Glu Val Met Ala Phe Lys Asn Glu Glu 
        275                 280                 285             


Arg Gly Arg Leu Ser Asp Phe Ala Ala Arg His Gly Met Ala Phe Glu 
    290                 295                 300                 


Ala Gly Arg Thr Pro Trp His Val Pro Ala Asp Val Ala Leu Pro Cys 
305                 310                 315                 320 


Ala Thr Gln Asn Glu Leu Asp Gly Asn Asp Ala Glu Thr Leu Leu Gly 
                325                 330                 335     


Asn Gly Val Ile Cys Val Ala Glu Gly Ala Asn Met Pro Ser Thr Leu 
            340                 345                 350         


Glu Ala Val Asp Arg Phe Val Asp Ala Lys Ile Leu Tyr Ala Pro Gly 
        355                 360                 365             


Lys Ala Ser Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met Ser 
    370                 375                 380                 


Gln Asn Ala Met Arg Leu Ser Trp His His Ala Glu Val Asp Glu Lys 
385                 390                 395                 400 


Leu His Ala Ile Met Lys Asp Ile His Gln Asn Cys Ile His His Gly 
                405                 410                 415     


Gln Lys Ala Asp Gly Tyr Ile Asn Tyr Val Glu Gly Ala Asn Ile Ala 
            420                 425                 430         


Gly Phe Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Val Ile 
        435                 440                 445         


<210>  61
<211>  1395
<212>  DNA
<213>  C. necator

<400>  61
atgaagtcag agttgagtgc gcatcttgcg gcgccagccg gggcgctgac cccggctccg       60

cggttcaaca ccgtcgaaga cgctcaagac tatctgctgg cgcgcggcgt cagctacgtc      120

ctcgcgcagt tcgtcgatat ccacggcgtc gccaaggcca aatcggtgcc agtggcgcat      180

cttggctcgg tcctggcaga gggtgcgggc tttgccggct ttgccatctg gggcgtcggc      240

attgaaccgc atggcccgga cttcatggct cgcggggatc tcgataccat cgggctggtg      300

ccatggcagc cgggcctggc ccggatcgta tgcgaagggc atgtcgatgg tgcgccatgg      360

cagtacgaca gccgggtcgt cctgaagcgg cagatcgcca ggctctcgca aggtggctac      420

acgctttata ccggcctcga gcctgagttt tcgctgctgc gccgtgacga caaaggcggc      480

atcggtccgt gcgacccgag cgatacgctg gccaagcctt gctacgacta caaggggctg      540

tcgcgcacgc gtactttcct ggagcgtctg tccaacggac tgcgcgccgc gggaatcgat      600

gtctaccaga tcgaccatga agacgccaac gggcaattcg aactgaatta caccttcacc      660

gactgcctga cgtcttgcga ccatttcatc ttcttcaaga tggcggcatc ggaaatcgcc      720

aacgagctgg gcctggtgtg ctccttcatg ccgaagccgt ttgcaaaccg ccccggcaac      780

ggcatgcata tgcacatgtc gatcggcgat ggccagcgca acctgtttgc tgacaagagc      840

gacccgcgcg ggctggacct gtcccagctg gcctatcact tccttggcgg gctgctggcc      900

catgcgccgg cgctcacggc gctttgcgcg cccaccgtca attcctacaa gcggctcgtg      960

gtgggccgtt ccctcaccgg cgccacctgg gctcccgcgt atatcagcta tggcgacaac     1020

aatcgctcga gcatgatccg catccccaag ggccggctgg aactgcggct gcccgatggc     1080

gccgccaacc cgtatctcgc cacagcggcc gtgattgcgg cggggcttga cggcatcgac     1140

cggaagctcg atcccggcgc accgcgcaac accaatctct atgagtggag cgaggcgcag     1200

ctggccgaag ccggcatcgg cctgctaccc cagaaccttg gcagcgcgct ggatgccctc     1260

gaagccgatg cgctgataac cgaggcactg ggacccgttg cgcaagagtt cctgaagctc     1320

aagcgcatgg agtggctcga atatcaacgg catgtctcgg actgggaagt gaagcagtac     1380

ctggaattct tttga                                                      1395


<210>  62
<211>  464
<212>  PRT
<213>  C. necator

<400>  62

Met Lys Ser Glu Leu Ser Ala His Leu Ala Ala Pro Ala Gly Ala Leu 
1               5                   10                  15      


Thr Pro Ala Pro Arg Phe Asn Thr Val Glu Asp Ala Gln Asp Tyr Leu 
            20                  25                  30          


Leu Ala Arg Gly Val Ser Tyr Val Leu Ala Gln Phe Val Asp Ile His 
        35                  40                  45              


Gly Val Ala Lys Ala Lys Ser Val Pro Val Ala His Leu Gly Ser Val 
    50                  55                  60                  


Leu Ala Glu Gly Ala Gly Phe Ala Gly Phe Ala Ile Trp Gly Val Gly 
65                  70                  75                  80  


Ile Glu Pro His Gly Pro Asp Phe Met Ala Arg Gly Asp Leu Asp Thr 
                85                  90                  95      


Ile Gly Leu Val Pro Trp Gln Pro Gly Leu Ala Arg Ile Val Cys Glu 
            100                 105                 110         


Gly His Val Asp Gly Ala Pro Trp Gln Tyr Asp Ser Arg Val Val Leu 
        115                 120                 125             


Lys Arg Gln Ile Ala Arg Leu Ser Gln Gly Gly Tyr Thr Leu Tyr Thr 
    130                 135                 140                 


Gly Leu Glu Pro Glu Phe Ser Leu Leu Arg Arg Asp Asp Lys Gly Gly 
145                 150                 155                 160 


Ile Gly Pro Cys Asp Pro Ser Asp Thr Leu Ala Lys Pro Cys Tyr Asp 
                165                 170                 175     


Tyr Lys Gly Leu Ser Arg Thr Arg Thr Phe Leu Glu Arg Leu Ser Asn 
            180                 185                 190         


Gly Leu Arg Ala Ala Gly Ile Asp Val Tyr Gln Ile Asp His Glu Asp 
        195                 200                 205             


Ala Asn Gly Gln Phe Glu Leu Asn Tyr Thr Phe Thr Asp Cys Leu Thr 
    210                 215                 220                 


Ser Cys Asp His Phe Ile Phe Phe Lys Met Ala Ala Ser Glu Ile Ala 
225                 230                 235                 240 


Asn Glu Leu Gly Leu Val Cys Ser Phe Met Pro Lys Pro Phe Ala Asn 
                245                 250                 255     


Arg Pro Gly Asn Gly Met His Met His Met Ser Ile Gly Asp Gly Gln 
            260                 265                 270         


Arg Asn Leu Phe Ala Asp Lys Ser Asp Pro Arg Gly Leu Asp Leu Ser 
        275                 280                 285             


Gln Leu Ala Tyr His Phe Leu Gly Gly Leu Leu Ala His Ala Pro Ala 
    290                 295                 300                 


Leu Thr Ala Leu Cys Ala Pro Thr Val Asn Ser Tyr Lys Arg Leu Val 
305                 310                 315                 320 


Val Gly Arg Ser Leu Thr Gly Ala Thr Trp Ala Pro Ala Tyr Ile Ser 
                325                 330                 335     


Tyr Gly Asp Asn Asn Arg Ser Ser Met Ile Arg Ile Pro Lys Gly Arg 
            340                 345                 350         


Leu Glu Leu Arg Leu Pro Asp Gly Ala Ala Asn Pro Tyr Leu Ala Thr 
        355                 360                 365             


Ala Ala Val Ile Ala Ala Gly Leu Asp Gly Ile Asp Arg Lys Leu Asp 
    370                 375                 380                 


Pro Gly Ala Pro Arg Asn Thr Asn Leu Tyr Glu Trp Ser Glu Ala Gln 
385                 390                 395                 400 


Leu Ala Glu Ala Gly Ile Gly Leu Leu Pro Gln Asn Leu Gly Ser Ala 
                405                 410                 415     


Leu Asp Ala Leu Glu Ala Asp Ala Leu Ile Thr Glu Ala Leu Gly Pro 
            420                 425                 430         


Val Ala Gln Glu Phe Leu Lys Leu Lys Arg Met Glu Trp Leu Glu Tyr 
        435                 440                 445             


Gln Arg His Val Ser Asp Trp Glu Val Lys Gln Tyr Leu Glu Phe Phe 
    450                 455                 460                 


