                         SEQUENCE LISTING

<110>  Tets, Viktor Veniaminovich
       Tets, Georgy Viktorovich
 
<120>  TETZ-PROTEINS AND PRION-LIKE PROTEINS AND ASSOCIATED METHODS

<130>  244008.000108

<150>  US 62/664,670
<151>  2018-04-30

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  920
<212>  PRT
<213>  Human herpes virus 8

<400>  1

Met Arg Val Lys Glu Met Arg Lys His Trp Gln His Leu Trp Thr Gly 
1               5                   10                  15      


Gly Ile Leu Leu Leu Gly Met Leu Met Ile Cys Ser Thr Ala Gln Asp 
            20                  25                  30          


Ala Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Glu Leu Ile Val Thr Asn Ser Thr Asn Gly Asn Asn 
    130                 135                 140                 


Thr Asn Ser His Ser Thr Arg Gly Asn Asp Thr Ile Gly Asn Ser Thr 
145                 150                 155                 160 


Ser Trp Lys Glu Met Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Pro Thr Ser Val Lys Asp Lys Met Gln Lys Gln Tyr Ala Leu Phe Tyr 
            180                 185                 190         


Lys Leu Asp Val Val Ala Ile Asn Asp Asp Asn Asn Lys Asn Ser Ser 
        195                 200                 205             


Asn Tyr Asn Ser Ser Lys Leu Ser Ser Ser Asn Ser Asn Cys Gly Lys 
    210                 215                 220                 


Ser Asp Asn Asn Ser Ser Cys Asn Cys Ser Ser Ser Asn Asn Asn Cys 
225                 230                 235                 240 


Ser Ser Ser Asn His Ser Ser Asn Tyr Ser Ser Tyr Ile Leu Ile Ser 
                245                 250                 255     


Cys Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
            260                 265                 270         


Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys 
        275                 280                 285             


Cys Asn Asp Lys Arg Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser 
    290                 295                 300                 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
305                 310                 315                 320 


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
                325                 330                 335     


Asn Ile Ser Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser 
            340                 345                 350         


Val Ala Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile 
        355                 360                 365             


Arg Ile Gly Pro Gly Arg Thr Phe Tyr Ala Ala Glu Lys Ile Ile Gly 
    370                 375                 380                 


Asp Ile Arg Lys Ala Tyr Cys Ile Ile Asn Gly Thr Lys Trp Asn Glu 
385                 390                 395                 400 


Thr Leu Arg Leu Ile Val Ala Lys Leu Arg Glu Gln Glu Gln Ile Gly 
                405                 410                 415     


Glu Asn Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu 
            420                 425                 430         


Ile Glu Asn His Ile Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn 
        435                 440                 445             


Thr Thr Gln Leu Phe Asn Ser Thr Trp Tyr Ser Asn Gly Thr Trp Ile 
    450                 455                 460                 


Gly Lys Asn Phe Thr Gly Ser Asn Ile Thr Leu Pro Cys Arg Ile Lys 
465                 470                 475                 480 


Gln Ile Val Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
                485                 490                 495     


Pro Ile Arg Gly Gln Ile Asn Cys Ile Ser Asn Ile Thr Gly Leu Leu 
            500                 505                 510         


Leu Thr Ser Asp Gly Gly Phe Arg Lys Thr Asn Glu Thr Thr Asn Met 
        515                 520                 525             


Thr Glu Thr Leu Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    530                 535                 540                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Ile 
545                 550                 555                 560 


Ala Pro Thr Gln Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
                565                 570                 575     


Val Gly Ile Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
            580                 585                 590         


Ser Thr Met Gly Ala Ala Ala Leu Thr Leu Thr Val Gln Ala Arg Gln 
        595                 600                 605             


Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
    610                 615                 620                 


Glu Ala Gln His Gln Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
625                 630                 635                 640 


Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln 
                645                 650                 655     


Leu Leu Gly Ile Trp Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
            660                 665                 670         


Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Leu Thr Glu Ile Trp Asn 
        675                 680                 685             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Glu Asn Tyr Thr Gly 
    690                 695                 700                 


Leu Ile Tyr Asn Leu Leu Glu Lys Ser Gln Asn Gln Gln Glu Lys Asn 
705                 710                 715                 720 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp 
                725                 730                 735     


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile 
            740                 745                 750         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
        755                 760                 765             


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Ile Ser Leu Gln Thr His 
    770                 775                 780                 


Leu Pro Val Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Gly Glu 
785                 790                 795                 800 


Gly Gly Glu Arg Asp Gly Asp Thr Ser Arg Arg Leu Val Ile Gly Leu 
                805                 810                 815     


Leu Pro Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
            820                 825                 830         


His Arg Leu Arg Asp Leu Leu Leu Ile Val Ala Arg Ile Val Glu Leu 
        835                 840                 845             


Leu Gly Arg Arg Gly Trp Glu Ile Leu Lys Tyr Trp Trp Asn Leu Leu 
    850                 855                 860                 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
865                 870                 875                 880 


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile 
                885                 890                 895     


Ala Arg Thr Ile Phe Arg Ala Phe Tyr His Ile Pro Arg Arg Ile Arg 
            900                 905                 910         


Gln Gly Phe Glu Arg Ala Leu Leu 
        915                 920 


<210>  2
<211>  152
<212>  PRT
<213>  Human herpes virus 3

<400>  2

Met Gln Lys Gly Ser Ser Phe Lys Cys Tyr Met Cys Val Leu Phe Ser 
1               5                   10                  15      


Cys Phe Ile Ile Gly Ala Gly Ser Asn Asn Thr Ser Thr Gln Pro Pro 
            20                  25                  30          


Thr Thr Thr Asn Ser Met Ser Thr Thr Asn Gln Ala Thr Leu Gly Gln 
        35                  40                  45              


Thr Cys Phe Gln Cys Ala Phe Gln Ile Val Asn Asn Ser Thr Gln Asn 
    50                  55                  60                  


Phe Thr Val Thr Phe Ala Tyr His Glu Asn Cys His Leu Ser Phe Arg 
65                  70                  75                  80  


Thr His Thr Glu Ala Leu Ser Val Ser Thr Ile Ser His Tyr His His 
                85                  90                  95      


His Asp Cys Trp Val Ser Ala Leu Arg Ala Val Tyr Gln Gly Tyr Asn 
            100                 105                 110         


Val Thr Ile Asn Gln Thr His Tyr Cys Tyr Leu Pro Asn Val Glu Thr 
        115                 120                 125             


Gly Ile Asn Pro Ala Val Val Arg Leu Ala Cys Ala Val Val Leu Leu 
    130                 135                 140                 


Val Lys Leu Ala Gln Phe Trp Thr 
145                 150         


<210>  3
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide (heavy chain of Rituximab chimeric antibody)

<400>  3

Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
            20                  25                  30          


Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  4
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide (light chain of Rituximab chimeric antibody)

<400>  4

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  5
<211>  478
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide (Rituximab-Mod)

<400>  5

Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
            20                  25                  30          


Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn Gln Asn 
465                 470                 475             


