                         SEQUENCE LISTING

<110>  UNIVERSITY OF ULSTER
 
<120>  A method of diagnosing or prognosing a neurological disorder in a
        subject

<130>  P122497PC00

<150>  GB1807178.7
<151>  2018-05-01

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  2
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  3
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  4
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro 
1               5                   10                  15      


Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser 
            20                  25                  30          


Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His 
        35                  40                  45              


Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met 
    50                  55                  60                  


Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val 
65                  70                  75                  80  


Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn 
                85                  90                  95      


Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn 
            100                 105                 110         


Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr 
        115                 120                 125             


Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu 
    130                 135                 140                 


Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu 
145                 150                 155                 160 


Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly 
                165                 170                 175     


Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu 
            180                 185                 190         


Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val 
        195                 200                 205             


Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser 
    210                 215                 220                 


Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn 
225                 230                 235                 240 


Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala 
                245                 250                 255     


Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile 
            260                 265                 270         


Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg 
        275                 280                 285             


Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu 
    290                 295                 300                 


Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser 
305                 310                 315                 320 


Lys Ala Asn Phe Ala Lys Ile Thr Thr Gly Ser Glu Asn Leu His Val 
                325                 330                 335     


Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr 
            340                 345                 350         


Lys Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro 
        355                 360                 365             


Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn 
    370                 375                 380                 


Pro Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro 
385                 390                 395             


<210>  5
<211>  4684
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr 
1               5                   10                  15      


Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg 
            20                  25                  30          


Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val 
        35                  40                  45              


Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr 
    50                  55                  60                  


Phe Ala Trp Cys His Phe Tyr Trp Tyr Leu Thr Asn Glu Gly Ile Ala 
65                  70                  75                  80  


His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Pro Ala Ser 
                85                  90                  95      


Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg 
            100                 105                 110         


Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys 
        115                 120                 125             


Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Val Tyr Arg Arg Lys Glu 
    130                 135                 140                 


Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln 
145                 150                 155                 160 


Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu 
                165                 170                 175     


Arg Asp Arg Val Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His 
            180                 185                 190         


Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg 
        195                 200                 205             


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser 
    210                 215                 220                 


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val 
225                 230                 235                 240 


Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn 
                245                 250                 255     


Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly 
            260                 265                 270         


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val 
        275                 280                 285             


Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp 
    290                 295                 300                 


Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe 
305                 310                 315                 320 


Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg 
                325                 330                 335     


His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn 
            340                 345                 350         


Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly 
        355                 360                 365             


Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp 
    370                 375                 380                 


Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro 
385                 390                 395                 400 


Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu 
                405                 410                 415     


Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met 
            420                 425                 430         


Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe 
        435                 440                 445             


Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met 
    450                 455                 460                 


Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr 
465                 470                 475                 480 


Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro 
                485                 490                 495     


Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val 
            500                 505                 510         


Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu 
        515                 520                 525             


Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu 
    530                 535                 540                 


Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp Val 
545                 550                 555                 560 


Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu 
                565                 570                 575     


Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp 
            580                 585                 590         


Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr 
        595                 600                 605             


Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu 
    610                 615                 620                 


Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val 
625                 630                 635                 640 


Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp 
                645                 650                 655     


Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn 
            660                 665                 670         


Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val 
        675                 680                 685             


Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu 
    690                 695                 700                 


Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser 
705                 710                 715                 720 


Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu 
                725                 730                 735     


Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu 
            740                 745                 750         


Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp 
        755                 760                 765             


Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg 
    770                 775                 780                 


Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg 
785                 790                 795                 800 


Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly 
                805                 810                 815     


Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser 
            820                 825                 830         


Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys 
        835                 840                 845             


Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe 
    850                 855                 860                 


Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu 
865                 870                 875                 880 


Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg 
                885                 890                 895     


Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn 
            900                 905                 910         


Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val 
        915                 920                 925             


Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu 
    930                 935                 940                 


Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His 
945                 950                 955                 960 


Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp 
                965                 970                 975     


Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys 
            980                 985                 990         


Phe Leu Val Pro Pro Pro Asn Gln  Glu Ala Gln Glu Ala  Val Thr Arg 
        995                 1000                 1005             


Leu Glu  Ala Gln His Gln Ala  Leu Val Thr Leu Trp  His Gln Leu 
    1010                 1015                 1020             


His Val  Asp Met Lys Ser Leu  Leu Ala Trp Gln Ser  Leu Arg Arg 
    1025                 1030                 1035             


Asp Val  Gln Leu Ile Arg Ser  Trp Ser Leu Ala Thr  Phe Arg Thr 
    1040                 1045                 1050             


Leu Lys  Pro Glu Glu Gln Arg  Gln Ala Leu His Ser  Leu Glu Leu 
    1055                 1060                 1065             


His Tyr  Gln Ala Phe Leu Arg  Asp Ser Gln Asp Ala  Gly Gly Phe 
    1070                 1075                 1080             


Gly Pro  Glu Asp Arg Leu Met  Ala Glu Arg Glu Tyr  Gly Ser Cys 
    1085                 1090                 1095             


Ser His  His Tyr Gln Gln Leu  Leu Gln Ser Leu Glu  Gln Gly Ala 
    1100                 1105                 1110             


Gln Glu  Glu Ser Arg Cys Gln  Arg Cys Ile Ser Glu  Leu Lys Asp 
    1115                 1120                 1125             


Ile Arg  Leu Gln Leu Glu Ala  Cys Glu Thr Arg Thr  Val His Arg 
    1130                 1135                 1140             


Leu Arg  Leu Pro Leu Asp Lys  Glu Pro Ala Arg Glu  Cys Ala Gln 
    1145                 1150                 1155             


Arg Ile  Ala Glu Gln Gln Lys  Ala Gln Ala Glu Val  Glu Gly Leu 
    1160                 1165                 1170             


Gly Lys  Gly Val Ala Arg Leu  Ser Ala Glu Ala Glu  Lys Val Leu 
    1175                 1180                 1185             


Ala Leu  Pro Glu Pro Ser Pro  Ala Ala Pro Thr Leu  Arg Ser Glu 
    1190                 1195                 1200             


Leu Glu  Leu Thr Leu Gly Lys  Leu Glu Gln Val Arg  Ser Leu Ser 
    1205                 1210                 1215             


Ala Ile  Tyr Leu Glu Lys Leu  Lys Thr Ile Ser Leu  Val Ile Arg 
    1220                 1225                 1230             


Gly Thr  Gln Gly Ala Glu Glu  Val Leu Arg Ala His  Glu Glu Gln 
    1235                 1240                 1245             


Leu Lys  Glu Ala Gln Ala Val  Pro Ala Thr Leu Pro  Glu Leu Glu 
    1250                 1255                 1260             


Ala Thr  Lys Ala Ser Leu Lys  Lys Leu Arg Ala Gln  Ala Glu Ala 
    1265                 1270                 1275             


Gln Gln  Pro Thr Phe Asp Ala  Leu Arg Asp Glu Leu  Arg Gly Ala 
    1280                 1285                 1290             


Gln Glu  Val Gly Glu Arg Leu  Gln Gln Arg His Gly  Glu Arg Asp 
    1295                 1300                 1305             


Val Glu  Val Glu Arg Trp Arg  Glu Arg Val Ala Gln  Leu Leu Glu 
    1310                 1315                 1320             


Arg Trp  Gln Ala Val Leu Ala  Gln Thr Asp Val Arg  Gln Arg Glu 
    1325                 1330                 1335             


Leu Glu  Gln Leu Gly Arg Gln  Leu Arg Tyr Tyr Arg  Glu Ser Ala 
    1340                 1345                 1350             


Asp Pro  Leu Gly Ala Trp Leu  Gln Asp Ala Arg Arg  Arg Gln Glu 
    1355                 1360                 1365             


Gln Ile  Gln Ala Met Pro Leu  Ala Asp Ser Gln Ala  Val Arg Glu 
    1370                 1375                 1380             


Gln Leu  Arg Gln Glu Gln Ala  Leu Leu Glu Glu Ile  Glu Arg His 
    1385                 1390                 1395             


Gly Glu  Lys Val Glu Glu Cys  Gln Arg Phe Ala Lys  Gln Tyr Ile 
    1400                 1405                 1410             


Asn Ala  Ile Lys Asp Tyr Glu  Leu Gln Leu Val Thr  Tyr Lys Ala 
    1415                 1420                 1425             


Gln Leu  Glu Pro Val Ala Ser  Pro Ala Lys Lys Pro  Lys Val Gln 
    1430                 1435                 1440             


Ser Gly  Ser Glu Ser Val Ile  Gln Glu Tyr Val Asp  Leu Arg Thr 
    1445                 1450                 1455             


His Tyr  Ser Glu Leu Thr Thr  Leu Thr Ser Gln Tyr  Ile Lys Phe 
    1460                 1465                 1470             


Ile Ser  Glu Thr Leu Arg Arg  Met Glu Glu Glu Glu  Arg Leu Ala 
    1475                 1480                 1485             


Glu Gln  Gln Arg Ala Glu Glu  Arg Glu Arg Leu Ala  Glu Val Glu 
    1490                 1495                 1500             


Ala Ala  Leu Glu Lys Gln Arg  Gln Leu Ala Glu Ala  His Ala Gln 
    1505                 1510                 1515             


Ala Lys  Ala Gln Ala Glu Arg  Glu Ala Lys Glu Leu  Gln Gln Arg 
    1520                 1525                 1530             


Met Gln  Glu Glu Val Val Arg  Arg Glu Glu Ala Ala  Val Asp Ala 
    1535                 1540                 1545             


Gln Gln  Gln Lys Arg Ser Ile  Gln Glu Glu Leu Gln  Gln Leu Arg 
    1550                 1555                 1560             


Gln Ser  Ser Glu Ala Glu Ile  Gln Ala Lys Ala Arg  Gln Ala Glu 
    1565                 1570                 1575             


Ala Ala  Glu Arg Ser Arg Leu  Arg Ile Glu Glu Glu  Ile Arg Val 
    1580                 1585                 1590             


Val Arg  Leu Gln Leu Glu Ala  Thr Glu Arg Gln Arg  Gly Gly Ala 
    1595                 1600                 1605             


Glu Gly  Glu Leu Gln Ala Leu  Arg Ala Arg Ala Glu  Glu Ala Glu 
    1610                 1615                 1620             


Ala Gln  Lys Arg Gln Ala Gln  Glu Glu Ala Glu Arg  Leu Arg Arg 
    1625                 1630                 1635             


Gln Val  Gln Asp Glu Ser Gln  Arg Lys Arg Gln Ala  Glu Val Glu 
    1640                 1645                 1650             


Leu Ala  Ser Arg Val Lys Ala  Glu Ala Glu Ala Ala  Arg Glu Lys 
    1655                 1660                 1665             


Gln Arg  Ala Leu Gln Ala Leu  Glu Glu Leu Arg Leu  Gln Ala Glu 
    1670                 1675                 1680             


Glu Ala  Glu Arg Arg Leu Arg  Gln Ala Glu Val Glu  Arg Ala Arg 
    1685                 1690                 1695             


Gln Val  Gln Val Ala Leu Glu  Thr Ala Gln Arg Ser  Ala Glu Ala 
    1700                 1705                 1710             


Glu Leu  Gln Ser Lys Arg Ala  Ser Phe Ala Glu Lys  Thr Ala Gln 
    1715                 1720                 1725             


Leu Glu  Arg Ser Leu Gln Glu  Glu His Val Ala Val  Ala Gln Leu 
    1730                 1735                 1740             


Arg Glu  Glu Ala Glu Arg Arg  Ala Gln Gln Gln Ala  Glu Ala Glu 
    1745                 1750                 1755             


Arg Ala  Arg Glu Glu Ala Glu  Arg Glu Leu Glu Arg  Trp Gln Leu 
    1760                 1765                 1770             


Lys Ala  Asn Glu Ala Leu Arg  Leu Arg Leu Gln Ala  Glu Glu Val 
    1775                 1780                 1785             


Ala Gln  Gln Lys Ser Leu Ala  Gln Ala Glu Ala Glu  Lys Gln Lys 
    1790                 1795                 1800             


Glu Glu  Ala Glu Arg Glu Ala  Arg Arg Arg Gly Lys  Ala Glu Glu 
    1805                 1810                 1815             


Gln Ala  Val Arg Gln Arg Glu  Leu Ala Glu Gln Glu  Leu Glu Lys 
    1820                 1825                 1830             


Gln Arg  Gln Leu Ala Glu Gly  Thr Ala Gln Gln Arg  Leu Ala Ala 
    1835                 1840                 1845             


Glu Gln  Glu Leu Ile Arg Leu  Arg Ala Glu Thr Glu  Gln Gly Glu 
    1850                 1855                 1860             


Gln Gln  Arg Gln Leu Leu Glu  Glu Glu Leu Ala Arg  Leu Gln Arg 
    1865                 1870                 1875             


Glu Ala  Ala Ala Ala Thr Gln  Lys Arg Gln Glu Leu  Glu Ala Glu 
    1880                 1885                 1890             


Leu Ala  Lys Val Arg Ala Glu  Met Glu Val Leu Leu  Ala Ser Lys 
    1895                 1900                 1905             


Ala Arg  Ala Glu Glu Glu Ser  Arg Ser Thr Ser Glu  Lys Ser Lys 
    1910                 1915                 1920             


Gln Arg  Leu Glu Ala Glu Ala  Gly Arg Phe Arg Glu  Leu Ala Glu 
    1925                 1930                 1935             


Glu Ala  Ala Arg Leu Arg Ala  Leu Ala Glu Glu Ala  Lys Arg Gln 
    1940                 1945                 1950             


Arg Gln  Leu Ala Glu Glu Asp  Ala Ala Arg Gln Arg  Ala Glu Ala 
    1955                 1960                 1965             


Glu Arg  Val Leu Ala Glu Lys  Leu Ala Ala Ile Gly  Glu Ala Thr 
    1970                 1975                 1980             


Arg Leu  Lys Thr Glu Ala Glu  Ile Ala Leu Lys Glu  Lys Glu Ala 
    1985                 1990                 1995             


Glu Asn  Glu Arg Leu Arg Arg  Leu Ala Glu Asp Glu  Ala Phe Gln 
    2000                 2005                 2010             


Arg Arg  Arg Leu Glu Glu Gln  Ala Ala Gln His Lys  Ala Asp Ile 
    2015                 2020                 2025             


Glu Glu  Arg Leu Ala Gln Leu  Arg Lys Ala Ser Asp  Ser Glu Leu 
    2030                 2035                 2040             


Glu Arg  Gln Lys Gly Leu Val  Glu Asp Thr Leu Arg  Gln Arg Arg 
    2045                 2050                 2055             


Gln Val  Glu Glu Glu Ile Leu  Ala Leu Lys Ala Ser  Phe Glu Lys 
    2060                 2065                 2070             


Ala Ala  Ala Gly Lys Ala Glu  Leu Glu Leu Glu Leu  Gly Arg Ile 
    2075                 2080                 2085             


Arg Ser  Asn Ala Glu Asp Thr  Leu Arg Ser Lys Glu  Gln Ala Glu 
    2090                 2095                 2100             


Leu Glu  Ala Ala Arg Gln Arg  Gln Leu Ala Ala Glu  Glu Glu Arg 
    2105                 2110                 2115             


Arg Arg  Arg Glu Ala Glu Glu  Arg Val Gln Lys Ser  Leu Ala Ala 
    2120                 2125                 2130             


Glu Glu  Glu Ala Ala Arg Gln  Arg Lys Ala Ala Leu  Glu Glu Val 
    2135                 2140                 2145             


Glu Arg  Leu Lys Ala Lys Val  Glu Glu Ala Arg Arg  Leu Arg Glu 
    2150                 2155                 2160             


Arg Ala  Glu Gln Glu Ser Ala  Arg Gln Leu Gln Leu  Ala Gln Glu 
    2165                 2170                 2175             


Ala Ala  Gln Lys Arg Leu Gln  Ala Glu Glu Lys Ala  His Ala Phe 
    2180                 2185                 2190             


Ala Val  Gln Gln Lys Glu Gln  Glu Leu Gln Gln Thr  Leu Gln Gln 
    2195                 2200                 2205             


Glu Gln  Ser Val Leu Asp Gln  Leu Arg Gly Glu Ala  Glu Ala Ala 
    2210                 2215                 2220             


Arg Arg  Ala Ala Glu Glu Ala  Glu Glu Ala Arg Val  Gln Ala Glu 
    2225                 2230                 2235             


Arg Glu  Ala Ala Gln Ser Arg  Arg Gln Val Glu Glu  Ala Glu Arg 
    2240                 2245                 2250             


Leu Lys  Gln Ser Ala Glu Glu  Gln Ala Gln Ala Arg  Ala Gln Ala 
    2255                 2260                 2265             


Gln Ala  Ala Ala Glu Lys Leu  Arg Lys Glu Ala Glu  Gln Glu Ala 
    2270                 2275                 2280             


Ala Arg  Arg Ala Gln Ala Glu  Gln Ala Ala Leu Arg  Gln Lys Gln 
    2285                 2290                 2295             


Ala Ala  Asp Ala Glu Met Glu  Lys His Lys Lys Phe  Ala Glu Gln 
    2300                 2305                 2310             


Thr Leu  Arg Gln Lys Ala Gln  Val Glu Gln Glu Leu  Thr Thr Leu 
    2315                 2320                 2325             


Arg Leu  Gln Leu Glu Glu Thr  Asp His Gln Lys Asn  Leu Leu Asp 
    2330                 2335                 2340             


Glu Glu  Leu Gln Arg Leu Lys  Ala Glu Ala Thr Glu  Ala Ala Arg 
    2345                 2350                 2355             


Gln Arg  Ser Gln Val Glu Glu  Glu Leu Phe Ser Val  Arg Val Gln 
    2360                 2365                 2370             


Met Glu  Glu Leu Ser Lys Leu  Lys Ala Arg Ile Glu  Ala Glu Asn 
    2375                 2380                 2385             


Arg Ala  Leu Ile Leu Arg Asp  Lys Asp Asn Thr Gln  Arg Phe Leu 
    2390                 2395                 2400             


Gln Glu  Glu Ala Glu Lys Met  Lys Gln Val Ala Glu  Glu Ala Ala 
    2405                 2410                 2415             


Arg Leu  Ser Val Ala Ala Gln  Glu Ala Ala Arg Leu  Arg Gln Leu 
    2420                 2425                 2430             


Ala Glu  Glu Asp Leu Ala Gln  Gln Arg Ala Leu Ala  Glu Lys Met 
    2435                 2440                 2445             


Leu Lys  Glu Lys Met Gln Ala  Val Gln Glu Ala Thr  Arg Leu Lys 
    2450                 2455                 2460             


Ala Glu  Ala Glu Leu Leu Gln  Gln Gln Lys Glu Leu  Ala Gln Glu 
    2465                 2470                 2475             


Gln Ala  Arg Arg Leu Gln Glu  Asp Lys Glu Gln Met  Ala Gln Gln 
    2480                 2485                 2490             


Leu Ala  Glu Glu Thr Gln Gly  Phe Gln Arg Thr Leu  Glu Ala Glu 
    2495                 2500                 2505             


Arg Gln  Arg Gln Leu Glu Met  Ser Ala Glu Ala Glu  Arg Leu Lys 
    2510                 2515                 2520             


Leu Arg  Val Ala Glu Met Ser  Arg Ala Gln Ala Arg  Ala Glu Glu 
    2525                 2530                 2535             


Asp Ala  Gln Arg Phe Arg Lys  Gln Ala Glu Glu Ile  Gly Glu Lys 
    2540                 2545                 2550             


Leu His  Arg Thr Glu Leu Ala  Thr Gln Glu Lys Val  Thr Leu Val 
    2555                 2560                 2565             


Gln Thr  Leu Glu Ile Gln Arg  Gln Gln Ser Asp His  Asp Ala Glu 
    2570                 2575                 2580             


Arg Leu  Arg Glu Ala Ile Ala  Glu Leu Glu Arg Glu  Lys Glu Lys 
    2585                 2590                 2595             


Leu Gln  Gln Glu Ala Lys Leu  Leu Gln Leu Lys Ser  Glu Glu Met 
    2600                 2605                 2610             


Gln Thr  Val Gln Gln Glu Gln  Leu Leu Gln Glu Thr  Gln Ala Leu 
    2615                 2620                 2625             


Gln Gln  Ser Phe Leu Ser Glu  Lys Asp Ser Leu Leu  Gln Arg Glu 
    2630                 2635                 2640             


Arg Phe  Ile Glu Gln Glu Lys  Ala Lys Leu Glu Gln  Leu Phe Gln 
    2645                 2650                 2655             


Asp Glu  Val Ala Lys Ala Gln  Gln Leu Arg Glu Glu  Gln Gln Arg 
    2660                 2665                 2670             


Gln Gln  Gln Gln Met Glu Gln  Glu Arg Gln Arg Leu  Val Ala Ser 
    2675                 2680                 2685             


Met Glu  Glu Ala Arg Arg Arg  Gln His Glu Ala Glu  Glu Gly Val 
    2690                 2695                 2700             


Arg Arg  Lys Gln Glu Glu Leu  Gln Gln Leu Glu Gln  Gln Arg Arg 
    2705                 2710                 2715             


Gln Gln  Glu Glu Leu Leu Ala  Glu Glu Asn Gln Arg  Leu Arg Glu 
    2720                 2725                 2730             


Gln Leu  Gln Leu Leu Glu Glu  Gln His Arg Ala Ala  Leu Ala His 
    2735                 2740                 2745             


Ser Glu  Glu Val Thr Ala Ser  Gln Val Ala Ala Thr  Lys Thr Leu 
    2750                 2755                 2760             


Pro Asn  Gly Arg Asp Ala Leu  Asp Gly Pro Ala Ala  Glu Ala Glu 
    2765                 2770                 2775             


Pro Glu  His Ser Phe Asp Gly  Leu Arg Arg Lys Val  Ser Ala Gln 
    2780                 2785                 2790             


Arg Leu  Gln Glu Ala Gly Ile  Leu Ser Ala Glu Glu  Leu Gln Arg 
    2795                 2800                 2805             


Leu Ala  Gln Gly His Thr Thr  Val Asp Glu Leu Ala  Arg Arg Glu 
    2810                 2815                 2820             


Asp Val  Arg His Tyr Leu Gln  Gly Arg Ser Ser Ile  Ala Gly Leu 
    2825                 2830                 2835             


Leu Leu  Lys Ala Thr Asn Glu  Lys Leu Ser Val Tyr  Ala Ala Leu 
    2840                 2845                 2850             


Gln Arg  Gln Leu Leu Ser Pro  Gly Thr Ala Leu Ile  Leu Leu Glu 
    2855                 2860                 2865             


Ala Gln  Ala Ala Ser Gly Phe  Leu Leu Asp Pro Val  Arg Asn Arg 
    2870                 2875                 2880             


Arg Leu  Thr Val Asn Glu Ala  Val Lys Glu Gly Val  Val Gly Pro 
    2885                 2890                 2895             


Glu Leu  His His Lys Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly 
    2900                 2905                 2910             


Tyr Lys  Asp Pro Tyr Thr Gly  Gln Gln Ile Ser Leu  Phe Gln Ala 
    2915                 2920                 2925             


Met Gln  Lys Gly Leu Ile Val  Arg Glu His Gly Ile  Arg Leu Leu 
    2930                 2935                 2940             


Glu Ala  Gln Ile Ala Thr Gly  Gly Val Ile Asp Pro  Val His Ser 
    2945                 2950                 2955             


His Arg  Val Pro Val Asp Val  Ala Tyr Arg Arg Gly  Tyr Phe Asp 
    2960                 2965                 2970             


Glu Glu  Met Asn Arg Val Leu  Ala Asp Pro Ser Asp  Asp Thr Lys 
    2975                 2980                 2985             


Gly Phe  Phe Asp Pro Asn Thr  His Glu Asn Leu Thr  Tyr Leu Gln 
    2990                 2995                 3000             


Leu Leu  Glu Arg Cys Val Glu  Asp Pro Glu Thr Gly  Leu Cys Leu 
    3005                 3010                 3015             


Leu Pro  Leu Thr Asp Lys Ala  Ala Lys Gly Gly Glu  Leu Val Tyr 
    3020                 3025                 3030             


Thr Asp  Ser Glu Ala Arg Asp  Val Phe Glu Lys Ala  Thr Val Ser 
    3035                 3040                 3045             


Ala Pro  Phe Gly Lys Phe Gln  Gly Lys Thr Val Thr  Ile Trp Glu 
    3050                 3055                 3060             


Ile Ile  Asn Ser Glu Tyr Phe  Thr Ala Glu Gln Arg  Arg Asp Leu 
    3065                 3070                 3075             


Leu Arg  Gln Phe Arg Thr Gly  Arg Ile Thr Val Glu  Lys Ile Ile 
    3080                 3085                 3090             


Lys Ile  Ile Ile Thr Val Val  Glu Glu Gln Glu Gln  Lys Gly Arg 
    3095                 3100                 3105             


Leu Cys  Phe Glu Gly Leu Arg  Ser Leu Val Pro Ala  Ala Glu Leu 
    3110                 3115                 3120             


Leu Glu  Ser Arg Val Ile Asp  Arg Glu Leu Tyr Gln  Gln Leu Gln 
    3125                 3130                 3135             


Arg Gly  Glu Arg Ser Val Arg  Asp Val Ala Glu Val  Asp Thr Val 
    3140                 3145                 3150             


Arg Arg  Ala Leu Arg Gly Ala  Asn Val Ile Ala Gly  Val Trp Leu 
    3155                 3160                 3165             


Glu Glu  Ala Gly Gln Lys Leu  Ser Ile Tyr Asn Ala  Leu Lys Lys 
    3170                 3175                 3180             


Asp Leu  Leu Pro Ser Asp Met  Ala Val Ala Leu Leu  Glu Ala Gln 
    3185                 3190                 3195             


Ala Gly  Thr Gly His Ile Ile  Asp Pro Ala Thr Ser  Ala Arg Leu 
    3200                 3205                 3210             


Thr Val  Asp Glu Ala Val Arg  Ala Gly Leu Val Gly  Pro Glu Phe 
    3215                 3220                 3225             


His Glu  Lys Leu Leu Ser Ala  Glu Lys Ala Val Thr  Gly Tyr Arg 
    3230                 3235                 3240             


Asp Pro  Tyr Thr Gly Gln Ser  Val Ser Leu Phe Gln  Ala Leu Lys 
    3245                 3250                 3255             


Lys Gly  Leu Ile Pro Arg Glu  Gln Gly Leu Arg Leu  Leu Asp Ala 
    3260                 3265                 3270             


Gln Leu  Ser Thr Gly Gly Ile  Val Asp Pro Ser Lys  Ser His Arg 
    3275                 3280                 3285             


Val Pro  Leu Asp Val Ala Cys  Ala Arg Gly Cys Leu  Asp Glu Glu 
    3290                 3295                 3300             


Thr Ser  Arg Ala Leu Ser Ala  Pro Arg Ala Asp Ala  Lys Ala Tyr 
    3305                 3310                 3315             


Ser Asp  Pro Ser Thr Gly Glu  Pro Ala Thr Tyr Gly  Glu Leu Gln 
    3320                 3325                 3330             


Gln Arg  Cys Arg Pro Asp Gln  Leu Thr Gly Leu Ser  Leu Leu Pro 
    3335                 3340                 3345             


Leu Ser  Glu Lys Ala Ala Arg  Ala Arg Gln Glu Glu  Leu Tyr Ser 
    3350                 3355                 3360             


Glu Leu  Gln Ala Arg Glu Thr  Phe Glu Lys Thr Pro  Val Glu Val 
    3365                 3370                 3375             


Pro Val  Gly Gly Phe Lys Gly  Arg Thr Val Thr Val  Trp Glu Leu 
    3380                 3385                 3390             


Ile Ser  Ser Glu Tyr Phe Thr  Ala Glu Gln Arg Gln  Glu Leu Leu 
    3395                 3400                 3405             


Arg Gln  Phe Arg Thr Gly Lys  Val Thr Val Glu Lys  Val Ile Lys 
    3410                 3415                 3420             


Ile Leu  Ile Thr Ile Val Glu  Glu Val Glu Thr Leu  Arg Gln Glu 
    3425                 3430                 3435             


Arg Leu  Ser Phe Ser Gly Leu  Arg Ala Pro Val Pro  Ala Ser Glu 
    3440                 3445                 3450             


Leu Leu  Ala Ser Gly Val Leu  Ser Arg Ala Gln Phe  Glu Gln Leu 
    3455                 3460                 3465             


Lys Asp  Gly Lys Thr Thr Val  Lys Asp Leu Ser Glu  Leu Gly Ser 
    3470                 3475                 3480             


Val Arg  Thr Leu Leu Gln Gly  Ser Gly Cys Leu Ala  Gly Ile Tyr 
    3485                 3490                 3495             


Leu Glu  Asp Thr Lys Glu Lys  Val Ser Ile Tyr Glu  Ala Met Arg 
    3500                 3505                 3510             


Arg Gly  Leu Leu Arg Ala Thr  Thr Ala Ala Leu Leu  Leu Glu Ala 
    3515                 3520                 3525             


Gln Ala  Ala Thr Gly Phe Leu  Val Asp Pro Val Arg  Asn Gln Arg 
    3530                 3535                 3540             


Leu Tyr  Val His Glu Ala Val  Lys Ala Gly Val Val  Gly Pro Glu 
    3545                 3550                 3555             


Leu His  Glu Gln Leu Leu Ser  Ala Glu Lys Ala Val  Thr Gly Tyr 
    3560                 3565                 3570             


Arg Asp  Pro Tyr Ser Gly Ser  Thr Ile Ser Leu Phe  Gln Ala Met 
    3575                 3580                 3585             


Gln Lys  Gly Leu Val Leu Arg  Gln His Gly Ile Arg  Leu Leu Glu 
    3590                 3595                 3600             


Ala Gln  Ile Ala Thr Gly Gly  Ile Ile Asp Pro Val  His Ser His 
    3605                 3610                 3615             


Arg Val  Pro Val Asp Val Ala  Tyr Gln Arg Gly Tyr  Phe Ser Glu 
    3620                 3625                 3630             


Glu Met  Asn Arg Val Leu Ala  Asp Pro Ser Asp Asp  Thr Lys Gly 
    3635                 3640                 3645             


Phe Phe  Asp Pro Asn Thr His  Glu Asn Leu Thr Tyr  Arg Gln Leu 
    3650                 3655                 3660             


Leu Glu  Arg Cys Val Glu Asp  Pro Glu Thr Gly Leu  Arg Leu Leu 
    3665                 3670                 3675             


Pro Leu  Lys Gly Ala Glu Lys  Ala Glu Val Val Glu  Thr Thr Gln 
    3680                 3685                 3690             


Val Tyr  Thr Glu Glu Glu Thr  Arg Arg Ala Phe Glu  Glu Thr Gln 
    3695                 3700                 3705             


Ile Asp  Ile Pro Gly Gly Gly  Ser His Gly Gly Ser  Thr Met Ser 
    3710                 3715                 3720             


Leu Trp  Glu Val Met Gln Ser  Asp Leu Ile Pro Glu  Glu Gln Arg 
    3725                 3730                 3735             


Ala Gln  Leu Met Ala Asp Phe  Gln Ala Gly Arg Val  Thr Lys Glu 
    3740                 3745                 3750             


Arg Met  Ile Ile Ile Ile Ile  Glu Ile Ile Glu Lys  Thr Glu Ile 
    3755                 3760                 3765             


Ile Arg  Gln Gln Gly Leu Ala  Ser Tyr Asp Tyr Val  Arg Arg Arg 
    3770                 3775                 3780             


Leu Thr  Ala Glu Asp Leu Phe  Glu Ala Arg Ile Ile  Ser Leu Glu 
    3785                 3790                 3795             


Thr Tyr  Asn Leu Leu Arg Glu  Gly Thr Arg Ser Leu  Arg Glu Ala 
    3800                 3805                 3810             


Leu Glu  Ala Glu Ser Ala Trp  Cys Tyr Leu Tyr Gly  Thr Gly Ser 
    3815                 3820                 3825             


Val Ala  Gly Val Tyr Leu Pro  Gly Ser Arg Gln Thr  Leu Ser Ile 
    3830                 3835                 3840             


Tyr Gln  Ala Leu Lys Lys Gly  Leu Leu Ser Ala Glu  Val Ala Arg 
    3845                 3850                 3855             


Leu Leu  Leu Glu Ala Gln Ala  Ala Thr Gly Phe Leu  Leu Asp Pro 
    3860                 3865                 3870             


Val Lys  Gly Glu Arg Leu Thr  Val Asp Glu Ala Val  Arg Lys Gly 
    3875                 3880                 3885             


Leu Val  Gly Pro Glu Leu His  Asp Arg Leu Leu Ser  Ala Glu Arg 
    3890                 3895                 3900             


Ala Val  Thr Gly Tyr Arg Asp  Pro Tyr Thr Glu Gln  Thr Ile Ser 
    3905                 3910                 3915             


Leu Phe  Gln Ala Met Lys Lys  Glu Leu Ile Pro Thr  Glu Glu Ala 
    3920                 3925                 3930             


Leu Arg  Leu Leu Asp Ala Gln  Leu Ala Thr Gly Gly  Ile Val Asp 
    3935                 3940                 3945             


Pro Arg  Leu Gly Phe His Leu  Pro Leu Glu Val Ala  Tyr Gln Arg 
    3950                 3955                 3960             


Gly Tyr  Leu Asn Lys Asp Thr  His Asp Gln Leu Ser  Glu Pro Ser 
    3965                 3970                 3975             


Glu Val  Arg Ser Tyr Val Asp  Pro Ser Thr Asp Glu  Arg Leu Ser 
    3980                 3985                 3990             


Tyr Thr  Gln Leu Leu Arg Arg  Cys Arg Arg Asp Asp  Gly Thr Gly 
    3995                 4000                 4005             


Gln Leu  Leu Leu Pro Leu Ser  Asp Ala Arg Lys Leu  Thr Phe Arg 
    4010                 4015                 4020             


Gly Leu  Arg Lys Gln Ile Thr  Met Glu Glu Leu Val  Arg Ser Gln 
    4025                 4030                 4035             


Val Met  Asp Glu Ala Thr Ala  Leu Gln Leu Arg Glu  Gly Leu Thr 
    4040                 4045                 4050             


Ser Ile  Glu Glu Val Thr Lys  Asn Leu Gln Lys Phe  Leu Glu Gly 
    4055                 4060                 4065             


Thr Ser  Cys Ile Ala Gly Val  Phe Val Asp Ala Thr  Lys Glu Arg 
    4070                 4075                 4080             


Leu Ser  Val Tyr Gln Ala Met  Lys Lys Gly Ile Ile  Arg Pro Gly 
    4085                 4090                 4095             


Thr Ala  Phe Glu Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Tyr Val 
    4100                 4105                 4110             


Ile Asp  Pro Ile Lys Gly Leu  Lys Leu Thr Val Glu  Glu Ala Val 
    4115                 4120                 4125             


Arg Met  Gly Ile Val Gly Pro  Glu Phe Lys Asp Lys  Leu Leu Ser 
    4130                 4135                 4140             


Ala Glu  Arg Ala Val Thr Gly  Tyr Lys Asp Pro Tyr  Ser Gly Lys 
    4145                 4150                 4155             


Leu Ile  Ser Leu Phe Gln Ala  Met Lys Lys Gly Leu  Ile Leu Lys 
    4160                 4165                 4170             


Asp His  Gly Ile Arg Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly 
    4175                 4180                 4185             


Ile Ile  Asp Pro Glu Glu Ser  His Arg Leu Pro Val  Glu Val Ala 
    4190                 4195                 4200             


Tyr Lys  Arg Gly Leu Phe Asp  Glu Glu Met Asn Glu  Ile Leu Thr 
    4205                 4210                 4215             


Asp Pro  Ser Asp Asp Thr Lys  Gly Phe Phe Asp Pro  Asn Thr Glu 
    4220                 4225                 4230             


Glu Asn  Leu Thr Tyr Leu Gln  Leu Met Glu Arg Cys  Ile Thr Asp 
    4235                 4240                 4245             


Pro Gln  Thr Gly Leu Cys Leu  Leu Pro Leu Lys Glu  Lys Lys Arg 
    4250                 4255                 4260             


Glu Arg  Lys Thr Ser Ser Lys  Ser Ser Val Arg Lys  Arg Arg Val 
    4265                 4270                 4275             


Val Ile  Val Asp Pro Glu Thr  Gly Lys Glu Met Ser  Val Tyr Glu 
    4280                 4285                 4290             


Ala Tyr  Arg Lys Gly Leu Ile  Asp His Gln Thr Tyr  Leu Glu Leu 
    4295                 4300                 4305             


Ser Glu  Gln Glu Cys Glu Trp  Glu Glu Ile Thr Ile  Ser Ser Ser 
    4310                 4315                 4320             


Asp Gly  Val Val Lys Ser Met  Ile Ile Asp Arg Arg  Ser Gly Arg 
    4325                 4330                 4335             


Gln Tyr  Asp Ile Asp Asp Ala  Ile Ala Lys Asn Leu  Ile Asp Arg 
    4340                 4345                 4350             


Ser Ala  Leu Asp Gln Tyr Arg  Ala Gly Thr Leu Ser  Ile Thr Glu 
    4355                 4360                 4365             


Phe Ala  Asp Met Leu Ser Gly  Asn Ala Gly Gly Phe  Arg Ser Arg 
    4370                 4375                 4380             


Ser Ser  Ser Val Gly Ser Ser  Ser Ser Tyr Pro Ile  Ser Pro Ala 
    4385                 4390                 4395             


Val Ser  Arg Thr Gln Leu Ala  Ser Trp Ser Asp Pro  Thr Glu Glu 
    4400                 4405                 4410             


Thr Gly  Pro Val Ala Gly Ile  Leu Asp Thr Glu Thr  Leu Glu Lys 
    4415                 4420                 4425             


Val Ser  Ile Thr Glu Ala Met  His Arg Asn Leu Val  Asp Asn Ile 
    4430                 4435                 4440             


Thr Gly  Gln Arg Leu Leu Glu  Ala Gln Ala Cys Thr  Gly Gly Ile 
    4445                 4450                 4455             


Ile Asp  Pro Ser Thr Gly Glu  Arg Phe Pro Val Thr  Asp Ala Val 
    4460                 4465                 4470             


Asn Lys  Gly Leu Val Asp Lys  Ile Met Val Asp Arg  Ile Asn Leu 
    4475                 4480                 4485             


Ala Gln  Lys Ala Phe Cys Gly  Phe Glu Asp Pro Arg  Thr Lys Thr 
    4490                 4495                 4500             


Lys Met  Ser Ala Ala Gln Ala  Leu Lys Lys Gly Trp  Leu Tyr Tyr 
    4505                 4510                 4515             


Glu Ala  Gly Gln Arg Phe Leu  Glu Val Gln Tyr Leu  Thr Gly Gly 
    4520                 4525                 4530             


Leu Ile  Glu Pro Asp Thr Pro  Gly Arg Val Pro Leu  Asp Glu Ala 
    4535                 4540                 4545             


Leu Gln  Arg Gly Thr Val Asp  Ala Arg Thr Ala Gln  Lys Leu Arg 
    4550                 4555                 4560             


Asp Val  Gly Ala Tyr Ser Lys  Tyr Leu Thr Cys Pro  Lys Thr Lys 
    4565                 4570                 4575             


Leu Lys  Ile Ser Tyr Lys Asp  Ala Leu Asp Arg Ser  Met Val Glu 
    4580                 4585                 4590             


Glu Gly  Thr Gly Leu Arg Leu  Leu Glu Ala Ala Ala  Gln Ser Thr 
    4595                 4600                 4605             


Lys Gly  Tyr Tyr Ser Pro Tyr  Ser Val Ser Gly Ser  Gly Ser Thr 
    4610                 4615                 4620             


Ala Gly  Ser Arg Thr Gly Ser  Arg Thr Gly Ser Arg  Ala Gly Ser 
    4625                 4630                 4635             


Arg Arg  Gly Ser Phe Asp Ala  Thr Gly Ser Gly Phe  Ser Met Thr 
    4640                 4645                 4650             


Phe Ser  Ser Ser Ser Tyr Ser  Ser Ser Gly Tyr Gly  Arg Arg Tyr 
    4655                 4660                 4665             


Ala Ser  Gly Ser Ser Ala Ser  Leu Gly Gly Pro Glu  Ser Ala Val 
    4670                 4675                 4680             


Ala 
    


<210>  6
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  7
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 
625                 630                 635                 640 


Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 
            660                 665                 670         


Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 
        675                 680                 685             


Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 
    690                 695                 700                 


Lys Lys Thr Lys Phe Glu 
705                 710 


<210>  8
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  9
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  10
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  11
<211>  1838
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  12
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 
        195                 200                 205             


Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 
    210                 215                 220                 


Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 
225                 230                 235                 240 


Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 
                245                 250                 255     


Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 
            260                 265                 270         


Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 
        275                 280                 285             


Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 
    290                 295                 300                 


Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 
305                 310                 315                 320 


Phe Pro Phe 
            


<210>  13
<211>  2468
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
1               5                   10                  15      


Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 
            20                  25                  30          


Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 
        35                  40                  45              


Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
    50                  55                  60                  


Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
65                  70                  75                  80  


Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                85                  90                  95      


Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
            100                 105                 110         


Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
        115                 120                 125             


Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
    130                 135                 140                 


Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
145                 150                 155                 160 


Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                165                 170                 175     


Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
            180                 185                 190         


Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
        195                 200                 205             


Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
    210                 215                 220                 


Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
225                 230                 235                 240 


Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                245                 250                 255     


Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
            260                 265                 270         


Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
        275                 280                 285             


Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
    290                 295                 300                 


Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
305                 310                 315                 320 


Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 
                325                 330                 335     


Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
            340                 345                 350         


Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
        355                 360                 365             


Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 
    370                 375                 380                 


Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
385                 390                 395                 400 


Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 
                405                 410                 415     


Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
            420                 425                 430         


Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
        435                 440                 445             


Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 
    450                 455                 460                 


Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
465                 470                 475                 480 


Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                485                 490                 495     


Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
            500                 505                 510         


Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 
        515                 520                 525             


Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
    530                 535                 540                 


Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 
545                 550                 555                 560 


Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 
                565                 570                 575     


Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 
            580                 585                 590         


Pro Ile Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
        595                 600                 605             


Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 
    610                 615                 620                 


Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 
625                 630                 635                 640 


Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 
                645                 650                 655     


Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 
            660                 665                 670         


Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 
        675                 680                 685             


Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr 
    690                 695                 700                 


Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu 
705                 710                 715                 720 


Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 
                725                 730                 735     


Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 
            740                 745                 750         


Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 
        755                 760                 765             


Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 
    770                 775                 780                 


Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 
785                 790                 795                 800 


Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 
                805                 810                 815     


Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 
            820                 825                 830         


Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 
        835                 840                 845             


Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 
    850                 855                 860                 


Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 
865                 870                 875                 880 


Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 
                885                 890                 895     


Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 
            900                 905                 910         


Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 
        915                 920                 925             


Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 
    930                 935                 940                 


Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 
945                 950                 955                 960 


His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 
                965                 970                 975     


Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 
            980                 985                 990         


Val Ala Ser Gly Asp Asp Arg Ala  Glu Glu Asp Met Asp  Glu Ala Ile 
        995                 1000                 1005             


Glu Lys  Gly Glu Ala Glu Gln  Ser Glu Glu Glu Ala  Asp Glu Glu 
    1010                 1015                 1020             


Asp Lys  Ala Glu Asp Ala Arg  Glu Glu Glu Tyr Glu  Pro Glu Lys 
    1025                 1030                 1035             


Met Glu  Ala Glu Asp Tyr Val  Met Ala Val Val Asp  Lys Ala Ala 
    1040                 1045                 1050             


Glu Ala  Gly Gly Ala Glu Glu  Gln Tyr Gly Phe Leu  Thr Thr Pro 
    1055                 1060                 1065             


Thr Lys  Gln Leu Gly Ala Gln  Ser Pro Gly Arg Glu  Pro Ala Ser 
    1070                 1075                 1080             


Ser Ile  His Asp Glu Thr Leu  Pro Gly Gly Ser Glu  Ser Glu Ala 
    1085                 1090                 1095             


Thr Ala  Ser Asp Glu Glu Asn  Arg Glu Asp Gln Pro  Glu Glu Phe 
    1100                 1105                 1110             


Thr Ala  Thr Ser Gly Tyr Thr  Gln Ser Thr Ile Glu  Ile Ser Ser 
    1115                 1120                 1125             


Glu Pro  Thr Pro Met Asp Glu  Met Ser Thr Pro Arg  Asp Val Met 
    1130                 1135                 1140             


Ser Asp  Glu Thr Asn Asn Glu  Glu Thr Glu Ser Pro  Ser Gln Glu 
    1145                 1150                 1155             


Phe Val  Asn Ile Thr Lys Tyr  Glu Ser Ser Leu Tyr  Ser Gln Glu 
    1160                 1165                 1170             


Tyr Ser  Lys Pro Ala Asp Val  Thr Pro Leu Asn Gly  Phe Ser Glu 
    1175                 1180                 1185             


Gly Ser  Lys Thr Asp Ala Thr  Asp Gly Lys Asp Tyr  Asn Ala Ser 
    1190                 1195                 1200             


Ala Ser  Thr Ile Ser Pro Pro  Ser Ser Met Glu Glu  Asp Lys Phe 
    1205                 1210                 1215             


Ser Arg  Ser Ala Leu Arg Asp  Ala Tyr Cys Ser Glu  Val Lys Ala 
    1220                 1225                 1230             


Ser Thr  Thr Leu Asp Ile Lys  Asp Ser Ile Ser Ala  Val Ser Ser 
    1235                 1240                 1245             


Glu Lys  Val Ser Pro Ser Lys  Ser Pro Ser Leu Ser  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Pro Leu Glu Lys Thr  Pro Leu Gly Glu Arg  Ser Val Asn 
    1265                 1270                 1275             


Phe Ser  Leu Thr Pro Asn Glu  Ile Lys Val Ser Ala  Glu Ala Glu 
    1280                 1285                 1290             


Val Ala  Pro Val Ser Pro Glu  Val Thr Gln Glu Val  Val Glu Glu 
    1295                 1300                 1305             


His Cys  Ala Ser Pro Glu Asp  Lys Thr Leu Glu Val  Val Ser Pro 
    1310                 1315                 1320             


Ser Gln  Ser Val Thr Gly Ser  Ala Gly His Thr Pro  Tyr Tyr Gln 
    1325                 1330                 1335             


Ser Pro  Thr Asp Glu Lys Ser  Ser His Leu Pro Thr  Glu Val Ile 
    1340                 1345                 1350             


Glu Lys  Pro Pro Ala Val Pro  Val Ser Phe Glu Phe  Ser Asp Ala 
    1355                 1360                 1365             


Lys Asp  Glu Asn Glu Arg Ala  Ser Val Ser Pro Met  Asp Glu Pro 
    1370                 1375                 1380             


Val Pro  Asp Ser Glu Ser Pro  Ile Glu Lys Val Leu  Ser Pro Leu 
    1385                 1390                 1395             


Arg Ser  Pro Pro Leu Ile Gly  Ser Glu Ser Ala Tyr  Glu Ser Phe 
    1400                 1405                 1410             


Leu Ser  Ala Asp Asp Lys Ala  Ser Gly Arg Gly Ala  Glu Ser Pro 
    1415                 1420                 1425             


Phe Glu  Glu Lys Ser Gly Lys  Gln Gly Ser Pro Asp  Gln Val Ser 
    1430                 1435                 1440             


Pro Val  Ser Glu Met Thr Ser  Thr Ser Leu Tyr Gln  Asp Lys Gln 
    1445                 1450                 1455             


Glu Gly  Lys Ser Thr Asp Phe  Ala Pro Ile Lys Glu  Asp Phe Gly 
    1460                 1465                 1470             


Gln Glu  Lys Lys Thr Asp Asp  Val Glu Ala Met Ser  Ser Gln Pro 
    1475                 1480                 1485             


Ala Leu  Ala Leu Asp Glu Arg  Lys Leu Gly Asp Val  Ser Pro Thr 
    1490                 1495                 1500             


Gln Ile  Asp Val Ser Gln Phe  Gly Ser Phe Lys Glu  Asp Thr Lys 
    1505                 1510                 1515             


Met Ser  Ile Ser Glu Gly Thr  Val Ser Asp Lys Ser  Ala Thr Pro 
    1520                 1525                 1530             


Val Asp  Glu Gly Val Ala Glu  Asp Thr Tyr Ser His  Met Glu Gly 
    1535                 1540                 1545             


Val Ala  Ser Val Ser Thr Ala  Ser Val Ala Thr Ser  Ser Phe Pro 
    1550                 1555                 1560             


Glu Pro  Thr Thr Asp Asp Val  Ser Pro Ser Leu His  Ala Glu Val 
    1565                 1570                 1575             


Gly Ser  Pro His Ser Thr Glu  Val Asp Asp Ser Leu  Ser Val Ser 
    1580                 1585                 1590             


Val Val  Gln Thr Pro Thr Thr  Phe Gln Glu Thr Glu  Met Ser Pro 
    1595                 1600                 1605             


Ser Lys  Glu Glu Cys Pro Arg  Pro Met Ser Ile Ser  Pro Pro Asp 
    1610                 1615                 1620             


Phe Ser  Pro Lys Thr Ala Lys  Ser Arg Thr Pro Val  Gln Asp His 
    1625                 1630                 1635             


Arg Ser  Glu Gln Ser Ser Met  Ser Ile Glu Phe Gly  Gln Glu Ser 
    1640                 1645                 1650             


Pro Glu  Gln Ser Leu Ala Met  Asp Phe Ser Arg Gln  Ser Pro Asp 
    1655                 1660                 1665             


His Pro  Thr Val Gly Ala Gly  Val Leu His Ile Thr  Glu Asn Gly 
    1670                 1675                 1680             


Pro Thr  Glu Val Asp Tyr Ser  Pro Ser Asp Met Gln  Asp Ser Ser 
    1685                 1690                 1695             


Leu Ser  His Lys Ile Pro Pro  Met Glu Glu Pro Ser  Tyr Thr Gln 
    1700                 1705                 1710             


Asp Asn  Asp Leu Ser Glu Leu  Ile Ser Val Ser Gln  Val Glu Ala 
    1715                 1720                 1725             


Ser Pro  Ser Thr Ser Ser Ala  His Thr Pro Ser Gln  Ile Ala Ser 
    1730                 1735                 1740             


Pro Leu  Gln Glu Asp Thr Leu  Ser Asp Val Ala Pro  Pro Arg Asp 
    1745                 1750                 1755             


Met Ser  Leu Tyr Ala Ser Leu  Thr Ser Glu Lys Val  Gln Ser Leu 
    1760                 1765                 1770             


Glu Gly  Glu Lys Leu Ser Pro  Lys Ser Asp Ile Ser  Pro Leu Thr 
    1775                 1780                 1785             


Pro Arg  Glu Ser Ser Pro Leu  Tyr Ser Pro Thr Phe  Ser Asp Ser 
    1790                 1795                 1800             


Thr Ser  Ala Val Lys Glu Lys  Thr Ala Thr Cys His  Ser Ser Ser 
    1805                 1810                 1815             


Ser Pro  Pro Ile Asp Ala Ala  Ser Ala Glu Pro Tyr  Gly Phe Arg 
    1820                 1825                 1830             


Ala Ser  Val Leu Phe Asp Thr  Met Gln His His Leu  Ala Leu Asn 
    1835                 1840                 1845             


Arg Asp  Leu Ser Thr Pro Gly  Leu Glu Lys Asp Ser  Gly Gly Lys 
    1850                 1855                 1860             


Thr Pro  Gly Asp Phe Ser Tyr  Ala Tyr Gln Lys Pro  Glu Glu Thr 
    1865                 1870                 1875             


Thr Arg  Ser Pro Asp Glu Glu  Asp Tyr Asp Tyr Glu  Ser Tyr Glu 
    1880                 1885                 1890             


Lys Thr  Thr Arg Thr Ser Asp  Val Gly Gly Tyr Tyr  Tyr Glu Lys 
    1895                 1900                 1905             


Ile Glu  Arg Thr Thr Lys Ser  Pro Ser Asp Ser Gly  Tyr Ser Tyr 
    1910                 1915                 1920             


Glu Thr  Ile Gly Lys Thr Thr  Lys Thr Pro Glu Asp  Gly Asp Tyr 
    1925                 1930                 1935             


Ser Tyr  Glu Ile Ile Glu Lys  Thr Thr Arg Thr Pro  Glu Glu Gly 
    1940                 1945                 1950             


Gly Tyr  Ser Tyr Asp Ile Ser  Glu Lys Thr Thr Ser  Pro Pro Glu 
    1955                 1960                 1965             


Val Ser  Gly Tyr Ser Tyr Glu  Lys Thr Glu Arg Ser  Arg Arg Leu 
    1970                 1975                 1980             


Leu Asp  Asp Ile Ser Asn Gly  Tyr Asp Asp Ser Glu  Asp Gly Gly 
    1985                 1990                 1995             


His Thr  Leu Gly Asp Pro Ser  Tyr Ser Tyr Glu Thr  Thr Glu Lys 
    2000                 2005                 2010             


Ile Thr  Ser Phe Pro Glu Ser  Glu Gly Tyr Ser Tyr  Glu Thr Ser 
    2015                 2020                 2025             


Thr Lys  Thr Thr Arg Thr Pro  Asp Thr Ser Thr Tyr  Cys Tyr Glu 
    2030                 2035                 2040             


Thr Ala  Glu Lys Ile Thr Arg  Thr Pro Gln Ala Ser  Thr Tyr Ser 
    2045                 2050                 2055             


Tyr Glu  Thr Ser Asp Leu Cys  Tyr Thr Ala Glu Lys  Lys Ser Pro 
    2060                 2065                 2070             


Ser Glu  Ala Arg Gln Asp Val  Asp Leu Cys Leu Val  Ser Ser Cys 
    2075                 2080                 2085             


Glu Tyr  Lys His Pro Lys Thr  Glu Leu Ser Pro Ser  Phe Ile Asn 
    2090                 2095                 2100             


Pro Asn  Pro Leu Glu Trp Phe  Ala Ser Glu Glu Pro  Thr Glu Glu 
    2105                 2110                 2115             


Ser Glu  Lys Pro Leu Thr Gln  Ser Gly Gly Ala Pro  Pro Pro Pro 
    2120                 2125                 2130             


Gly Gly  Lys Gln Gln Gly Arg  Gln Cys Asp Glu Thr  Pro Pro Thr 
    2135                 2140                 2145             


Ser Val  Ser Glu Ser Ala Pro  Ser Gln Thr Asp Ser  Asp Val Pro 
    2150                 2155                 2160             


Pro Glu  Thr Glu Glu Cys Pro  Ser Ile Thr Ala Asp  Ala Asn Ile 
    2165                 2170                 2175             


Asp Ser  Glu Asp Glu Ser Glu  Thr Ile Pro Thr Asp  Lys Thr Val 
    2180                 2185                 2190             


Thr Tyr  Lys His Met Asp Pro  Pro Pro Ala Pro Val  Gln Asp Arg 
    2195                 2200                 2205             


Ser Pro  Ser Pro Arg His Pro  Asp Val Ser Met Val  Asp Pro Glu 
    2210                 2215                 2220             


Ala Leu  Ala Ile Glu Gln Asn  Leu Gly Lys Ala Leu  Lys Lys Asp 
    2225                 2230                 2235             


Leu Lys  Glu Lys Thr Lys Thr  Lys Lys Pro Gly Thr  Lys Thr Lys 
    2240                 2245                 2250             


Ser Ser  Ser Pro Val Lys Lys  Ser Asp Gly Lys Ser  Lys Pro Leu 
    2255                 2260                 2265             


Ala Ala  Ser Pro Lys Pro Ala  Gly Leu Lys Glu Ser  Ser Asp Lys 
    2270                 2275                 2280             


Val Ser  Arg Val Ala Ser Pro  Lys Lys Lys Glu Ser  Val Glu Lys 
    2285                 2290                 2295             


Ala Ala  Lys Pro Thr Thr Thr  Pro Glu Val Lys Ala  Ala Arg Gly 
    2300                 2305                 2310             


Glu Glu  Lys Asp Lys Glu Thr  Lys Asn Ala Ala Asn  Ala Ser Ala 
    2315                 2320                 2325             


Ser Lys  Ser Ala Lys Thr Ala  Thr Ala Gly Pro Gly  Thr Thr Lys 
    2330                 2335                 2340             


Thr Thr  Lys Ser Ser Ala Val  Pro Pro Gly Leu Pro  Val Tyr Leu 
    2345                 2350                 2355             


Asp Leu  Cys Tyr Ile Pro Asn  His Ser Asn Ser Lys  Asn Val Asp 
    2360                 2365                 2370             


Val Glu  Phe Phe Lys Arg Val  Arg Ser Ser Tyr Tyr  Val Val Ser 
    2375                 2380                 2385             


Gly Asn  Asp Pro Ala Ala Glu  Glu Pro Ser Arg Ala  Val Leu Asp 
    2390                 2395                 2400             


Ala Leu  Leu Glu Gly Lys Ala  Gln Trp Gly Ser Asn  Met Gln Val 
    2405                 2410                 2415             


Thr Leu  Ile Pro Thr His Asp  Ser Glu Val Met Arg  Glu Trp Tyr 
    2420                 2425                 2430             


Gln Glu  Thr His Glu Lys Gln  Gln Asp Leu Asn Ile  Met Val Leu 
    2435                 2440                 2445             


Ala Ser  Ser Ser Thr Val Val  Met Gln Asp Glu Ser  Phe Pro Ala 
    2450                 2455                 2460             


Cys Lys  Ile Glu Leu 
    2465             


<210>  14
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 
1               5                   10                  15      


Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 
            20                  25                  30          


Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 
        35                  40                  45              


Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 
    50                  55                  60                  


Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 
65                  70                  75                  80  


Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 
                85                  90                  95      


Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 
            100                 105                 110         


Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 
        115                 120                 125             


Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 
    130                 135                 140                 


Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 
145                 150                 155                 160 


Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 
                165                 170                 175     


Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 
            180                 185                 190         


Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 
        195                 200                 205             


Ala Ile Met Glu Leu Thr Met 
    210                 215 


<210>  15
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 
1               5                   10                  15      


Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 
            20                  25                  30          


Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 
        35                  40                  45              


Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 
    50                  55                  60                  


Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 
65                  70                  75                  80  


Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 
                85                  90                  95      


Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 
            100                 105                 110         


Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 
        115                 120                 125             


Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 
    130                 135                 140                 


Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 
145                 150                 155                 160 


Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 
                165                 170                 175     


Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 
            180                 185                 190         


Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 
        195                 200                 205             


Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 
    210                 215                 220                 


Glu Val Lys Asp Tyr Leu Ala Ala Ile Ala 
225                 230                 


<210>  16
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr 
1               5                   10                  15      


Gln Val Lys Phe Arg Arg Arg Arg Glu Gly Lys Thr Asp Tyr Tyr Ala 
            20                  25                  30          


Arg Lys Arg Leu Val Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys 
        35                  40                  45              


Tyr Arg Met Ile Val Arg Val Thr Asn Arg Asp Ile Ile Cys Gln Ile 
    50                  55                  60                  


Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala 
65                  70                  75                  80  


His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala 
                85                  90                  95      


Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg 
            100                 105                 110         


Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp 
        115                 120                 125             


Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys 
    130                 135                 140                 


Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe 
145                 150                 155                 160 


Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser 
                165                 170                 175     


Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala 
            180                 185                 190         


Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met 
        195                 200                 205             


Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser 
    210                 215                 220                 


Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr 
225                 230                 235                 240 


Lys Lys Ala His Ala Ala Ile Arg Glu Asn Pro Val Tyr Glu Lys Lys 
                245                 250                 255     


Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met Ser 
            260                 265                 270         


Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe Leu 
        275                 280                 285             


Arg Ala Gln Glu Arg Ala Ala Glu Ser 
    290                 295         


<210>  17
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe 
1               5                   10                  15      


Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys 
            20                  25                  30          


Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val 
        35                  40                  45              


Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val 
    50                  55                  60                  


Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn 
65                  70                  75                  80  


Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe 
                85                  90                  95      


Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val 
            100                 105                 110         


Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu 
        115                 120                 125             


Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe 
    130                 135                 140                 


Val Arg His Ile Leu Ser Gly 
145                 150     


<210>  18
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  19
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  20
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr 
1               5                   10                  15      


Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln 
        35                  40                  45              


Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala 
    50                  55                  60                  


Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala 
65                  70                  75                  80  


Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu 
                85                  90                  95      


Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu 
            100                 105                 110         


Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu 
        115                 120                 125             


Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu 
    130                 135                 140                 


Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val 
145                 150                 155                 160 


Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu 
                165                 170                 175     


Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro 
            180                 185                 190         


Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu 
        195                 200                 205             


Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser 
    210                 215                 220                 


Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys 
225                 230                 235                 240 


Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg 
                245                 250                 255     


Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys 
            260                 265                 270         


Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu 
        275                 280                 285             


Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp 
    290                 295                 300                 


His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro 
305                 310                 315                 320 


Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu 
                325                 330                 335     


Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly 
            340                 345                 350         


Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp 
        355                 360                 365             


Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val 
    370                 375                 380                 


Asp Lys Ser Asp Ser Asp 
385                 390 


<210>  21
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  22
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210>  23
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  24
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210>  25
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe 
1               5                   10                  15      


Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro 
            20                  25                  30          


Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg 
        35                  40                  45              


Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser 
    50                  55                  60                  


Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu 
65                  70                  75                  80  


Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly 
                85                  90                  95      


Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu 
            100                 105                 110         


Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln 
        115                 120                 125             


Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys 
    130                 135                 140                 


Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe 
145                 150                 155                 160 


Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu 
                165                 170                 175     


Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu 
            180                 185                 190         


Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu 
        195                 200                 205             


Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp 
    210                 215                 220                 


Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile 
225                 230                 235                 240 


Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr 
                245                 250                 255     


Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser 
            260                 265                 270         


Val Asp Ile Ala Ala Phe Asn Lys Ile 
        275                 280     


<210>  26
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr 
1               5                   10                  15      


Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg 
            20                  25                  30          


Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly 
        35                  40                  45              


Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly 
    50                  55                  60                  


Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala 
65                  70                  75                  80  


Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys 
                85                  90                  95      


Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe 
            100                 105                 110         


Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp 
        115                 120                 125             


Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp 
    130                 135                 140                 


Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly 
145                 150                 155                 160 


Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile 
                165                 170                 175     


Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val 
            180                 185                 190         


Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile 
        195                 200                 205             


Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu 
    210                 215                 220                 


Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln 
225                 230                 235                 240 


Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys 
                245                 250                 255     


Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala 
            260                 265                 270         


Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 
        275                 280                 285     


<210>  27
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 
1               5                   10                  15      


Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 
            20                  25                  30          


Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 
        35                  40                  45              


Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 
    50                  55                  60                  


Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 
65                  70                  75                  80  


Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 
                85                  90                  95      


Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly 
            100                 105                 110         


Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 
        115                 120                 125             


Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 
    130                 135                 140                 


Lys Glu Lys Glu 
145             


<210>  28
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Leu Leu Asp Val Cys Gly Ala Pro Arg Gly Gln Arg Pro Glu 
1               5                   10                  15      


Ser Ala Leu Pro Val Ala Gly Ser Gly Arg Arg Ser Asp Pro Gly His 
            20                  25                  30          


Tyr Ser Phe Ser Met Arg Ser Pro Glu Leu Ala Leu Pro Arg Gly Met 
        35                  40                  45              


Gln Pro Thr Glu Phe Phe Gln Ser Leu Gly Gly Asp Gly Glu Arg Asn 
    50                  55                  60                  


Val Gln Ile Glu Met Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe 
65                  70                  75                  80  


Gln His Gly Val Ile Ala Ala Val Asp Ser Arg Ala Ser Ala Gly Ser 
                85                  90                  95      


Tyr Ile Ser Ala Leu Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr 
            100                 105                 110         


Leu Leu Gly Thr Met Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu 
        115                 120                 125             


Arg Leu Leu Ala Lys Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu 
    130                 135                 140                 


Arg Ile Ser Val Ser Ala Ala Ser Lys Leu Leu Ser Asn Met Met Cys 
145                 150                 155                 160 


Gln Tyr Arg Gly Met Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp 
                165                 170                 175     


Asp Lys Lys Gly Pro Gly Leu Tyr Tyr Val Asp Glu His Gly Thr Arg 
            180                 185                 190         


Leu Ser Gly Asn Met Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr 
        195                 200                 205             


Gly Val Met Asp Ser Gly Tyr Arg Pro Asn Leu Ser Pro Glu Glu Ala 
    210                 215                 220                 


Tyr Asp Leu Gly Arg Arg Ala Ile Ala Tyr Ala Thr His Arg Asp Ser 
225                 230                 235                 240 


Tyr Ser Gly Gly Val Val Asn Met Tyr His Met Lys Glu Asp Gly Trp 
                245                 250                 255     


Val Lys Val Glu Ser Thr Asp Val Ser Asp Leu Leu His Gln Tyr Arg 
            260                 265                 270         


Glu Ala Asn Gln 
        275     


<210>  29
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
            260                 265                 270         


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
        275                 280                 285             


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
    290                 295                 300                 


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
305                 310                 315                 320 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
                325                 330                 335     


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
            340                 345                 350         


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
        355                 360                 365             


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
    370                 375                 380                 


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
385                 390                 395                 400 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
                405                 410                 415     


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
            420                 425                 430         


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
        435                 440                 445             


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
    450                 455                 460                 


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
465                 470                 475                 480 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
                485                 490                 495     


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
            500                 505                 510         


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 


<210>  30
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe 
1               5                   10                  15      


Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg 
            20                  25                  30          


Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr 
    50                  55                  60                  


Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile 
65                  70                  75                  80  


Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp 
                85                  90                  95      


Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser 
            100                 105                 110         


Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln 
        115                 120                 125             


Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly 
    130                 135                 140                 


Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly 
145                 150                 155                 160 


Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala 
                165                 170                 175     


Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu 
            180                 185                 190         


Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn 
        195                 200                 205             


Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn 
    210                 215                 220                 


Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr 
225                 230                 235                 240 


Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr 
                245                 250                 255     


Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln 
            260                 265                 270         


Thr Met Asp Thr Ser 
        275         


<210>  31
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Asp Phe Asp Asp Arg Val Ser Asp Glu Glu Lys Val Arg Ile 
1               5                   10                  15      


Ala Ala Lys Phe Ile Thr His Ala Pro Pro Gly Glu Phe Asn Glu Val 
            20                  25                  30          


Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
        35                  40                  45              


Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Met Asp Gln Phe Thr Pro 
    50                  55                  60                  


Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
65                  70                  75                  80  


Asp Leu Gly Asn Ser Arg Phe Leu Asp Pro Arg Asn Lys Ile Ser Phe 
                85                  90                  95      


Lys Phe Asp His Leu Arg Lys Glu Ala Ser Asp Pro Gln Pro Glu Glu 
            100                 105                 110         


Ala Asp Gly Gly Leu Lys Ser Trp Arg Glu Ser Cys Asp Ser Ala Leu 
        115                 120                 125             


Arg Ala Tyr Val Lys Asp His Tyr Ser Asn Gly Phe Cys Thr Val Tyr 
    130                 135                 140                 


Ala Lys Thr Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
145                 150                 155                 160 


His Gln Phe Gln Pro Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                165                 170                 175     


Trp Lys Phe Thr Ile Thr Pro Pro Thr Ala Gln Val Val Gly Val Leu 
            180                 185                 190         


Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
        195                 200                 205             


His Lys Asp Val Gln Asp Ser Leu Thr Val Ser Asn Glu Ala Gln Thr 
    210                 215                 220                 


Ala Lys Glu Phe Ile Lys Ile Ile Glu Asn Ala Glu Asn Glu Tyr Gln 
225                 230                 235                 240 


Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                245                 250                 255     


Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
            260                 265                 270         


Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
        275                 280                 285     


<210>  32
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  33
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu Leu Pro Pro Gln 
1               5                   10                  15      


Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro Gly Phe Gly Arg 
            20                  25                  30          


Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu Phe Ala Glu Glu 
        35                  40                  45              


Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly Pro Gly Pro Ala 
    50                  55                  60                  


Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln Glu Gly Val Val 
65                  70                  75                  80  


Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly Asp Leu Pro Glu 
                85                  90                  95      


His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu Glu Lys Ile Tyr 
            100                 105                 110         


Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr Leu Asn Leu Gln 
        115                 120                 125             


Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys Ala Phe Glu His 
    130                 135                 140                 


Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn Lys Leu Thr Leu 
145                 150                 155                 160 


Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val Asp Phe Ala Ala 
                165                 170                 175     


Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly Gln Lys Pro Asn 
            180                 185                 190         


Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala Asp Ala Gly Leu 
        195                 200                 205             


Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu Val Leu Ile Leu 
    210                 215                 220                 


Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu Pro Pro Ala Leu 
225                 230                 235                 240 


Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys Ile Pro Pro Gly 
                245                 250                 255     


Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr Leu Gln Asn Asn 
            260                 265                 270         


Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe Trp Lys Leu Ser 
        275                 280                 285             


Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu Ser Arg Val Pro 
    290                 295                 300                 


Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu Glu Lys Asn Ala 
305                 310                 315                 320 


Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile Arg Ser Leu Glu 
                325                 330                 335     


Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln Gly Ile His Pro 
            340                 345                 350         


Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val His Leu Tyr Asn 
        355                 360                 365             


Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg Arg Val Arg Thr 
    370                 375                 380                 


Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly Arg Glu Asp Phe 
385                 390                 395                 400 


Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser Tyr Asn Arg Ile 
                405                 410                 415     


Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys Leu Arg Leu Leu 
            420                 425                 430         


Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr Leu Pro Pro Gly 
        435                 440                 445             


Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg Asn Glu Leu Ala 
    450                 455                 460                 


Ala Leu Ala Arg Gly Ala Leu Val Gly Met Ala Gln Leu Arg Glu Leu 
465                 470                 475                 480 


Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu Gly Pro Arg Ala 
                485                 490                 495     


Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile Ala Gly Asn Gln 
            500                 505                 510         


Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu Glu Tyr Leu Tyr 
        515                 520                 525             


Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn Ala Phe Asp Ser 
    530                 535                 540                 


Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn Lys Leu Ala Val 
545                 550                 555                 560 


Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys His Leu Gln Val 
                565                 570                 575     


Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile Ser Lys Asp Arg 
            580                 585                 590         


Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        595                 600                 605             


Glu Glu Glu Thr Arg 
    610             


<210>  34
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  34

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  35
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Ser Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro His Ile 
            420 


<210>  36
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  37
<211>  5890
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210>  38
<211>  1894
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser 
1               5                   10                  15      


Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser 
            20                  25                  30          


Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu 
        35                  40                  45              


Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp 
    50                  55                  60                  


Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser 
65                  70                  75                  80  


Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe 
                85                  90                  95      


Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr 
            100                 105                 110         


Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser 
        115                 120                 125             


Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly 
    130                 135                 140                 


Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys 
145                 150                 155                 160 


Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala 
                165                 170                 175     


Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg 
            180                 185                 190         


Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val 
        195                 200                 205             


Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser 
    210                 215                 220                 


Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg 
225                 230                 235                 240 


Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu 
                245                 250                 255     


Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser 
            260                 265                 270         


Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln 
        275                 280                 285             


Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys 
    290                 295                 300                 


Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val 
305                 310                 315                 320 


Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg 
                325                 330                 335     


Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln 
            340                 345                 350         


Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val 
        355                 360                 365             


Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala 
    370                 375                 380                 


Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala 
385                 390                 395                 400 


Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp 
                405                 410                 415     


Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu 
            420                 425                 430         


Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys 
        435                 440                 445             


Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln 
    450                 455                 460                 


Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro 
465                 470                 475                 480 


Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser 
                485                 490                 495     


Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys 
            500                 505                 510         


Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys 
        515                 520                 525             


Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu 
    530                 535                 540                 


Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln 
545                 550                 555                 560 


Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val 
                565                 570                 575     


Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro 
            580                 585                 590         


Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro 
        595                 600                 605             


Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala 
    610                 615                 620                 


Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn 
625                 630                 635                 640 


Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser 
                645                 650                 655     


Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro 
            660                 665                 670         


Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His 
        675                 680                 685             


Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly 
    690                 695                 700                 


Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser 
705                 710                 715                 720 


Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu 
                725                 730                 735     


Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala 
            740                 745                 750         


Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser 
        755                 760                 765             


Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser 
    770                 775                 780                 


Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln 
785                 790                 795                 800 


Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His 
                805                 810                 815     


Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro 
            820                 825                 830         


Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser 
        835                 840                 845             


Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His 
    850                 855                 860                 


Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu 
865                 870                 875                 880 


Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser 
                885                 890                 895     


Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser 
            900                 905                 910         


Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn 
        915                 920                 925             


Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser 
    930                 935                 940                 


Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr 
945                 950                 955                 960 


Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala 
                965                 970                 975     


Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val 
            980                 985                 990         


Pro Arg Arg Met Thr Pro Gly Arg  Ala Pro Gln Gln Gln  Pro Pro Pro 
        995                 1000                 1005             


Pro Val  Ala Thr Ser Gln His  His Pro Gly Pro Gln  Ser Arg Asp 
    1010                 1015                 1020             


Ala Gly  Arg Ser Pro Ser Gln  Pro Arg Leu Ser Leu  Thr Gln Ala 
    1025                 1030                 1035             


Gly Arg  Pro Arg Pro Thr Ser  Gln Gly Arg Ser His  Ser Ser Ser 
    1040                 1045                 1050             


Asp Pro  Tyr Thr Ala Ser Ser  Arg Gly Met Leu Pro  Thr Ala Leu 
    1055                 1060                 1065             


Gln Asn  Gln Asp Glu Asp Ala  Gln Gly Ser Tyr Asp  Asp Asp Ser 
    1070                 1075                 1080             


Thr Glu  Val Glu Ala Gln Asp  Val Arg Ala Pro Ala  His Ala Ala 
    1085                 1090                 1095             


Arg Ala  Lys Glu Ala Ala Ala  Ser Leu Pro Lys His  Gln Gln Val 
    1100                 1105                 1110             


Glu Ser  Pro Thr Gly Ala Gly  Ala Gly Gly Asp His  Arg Ser Gln 
    1115                 1120                 1125             


Arg Gly  His Ala Ala Ser Pro  Ala Arg Pro Ser Arg  Pro Gly Gly 
    1130                 1135                 1140             


Pro Gln  Ser Arg Ala Arg Val  Pro Ser Arg Ala Ala  Pro Gly Lys 
    1145                 1150                 1155             


Ser Glu  Pro Pro Ser Lys Arg  Pro Leu Ser Ser Lys  Ser Gln Gln 
    1160                 1165                 1170             


Ser Val  Ser Ala Glu Asp Asp  Glu Glu Glu Asp Ala  Gly Phe Phe 
    1175                 1180                 1185             


Lys Gly  Gly Lys Glu Asp Leu  Leu Ser Ser Ser Val  Pro Lys Trp 
    1190                 1195                 1200             


Pro Ser  Ser Ser Thr Pro Arg  Gly Gly Lys Asp Ala  Asp Gly Ser 
    1205                 1210                 1215             


Leu Ala  Lys Glu Glu Arg Glu  Pro Ala Ile Ala Leu  Ala Pro Arg 
    1220                 1225                 1230             


Gly Gly  Ser Leu Ala Pro Val  Lys Arg Pro Leu Pro  Pro Pro Pro 
    1235                 1240                 1245             


Gly Ser  Ser Pro Arg Ala Ser  His Val Pro Ser Arg  Leu Pro Pro 
    1250                 1255                 1260             


Arg Ser  Ala Ala Thr Val Ser  Pro Val Ala Gly Thr  His Pro Trp 
    1265                 1270                 1275             


Pro Gln  Tyr Thr Thr Arg Ala  Pro Pro Gly His Phe  Ser Thr Thr 
    1280                 1285                 1290             


Pro Met  Leu Ser Leu Arg Gln  Arg Met Met His Ala  Arg Phe Arg 
    1295                 1300                 1305             


Asn Pro  Leu Ser Arg Gln Pro  Ala Arg Pro Ser Tyr  Arg Gln Gly 
    1310                 1315                 1320             


Tyr Asn  Gly Arg Pro Asn Val  Glu Gly Lys Val Leu  Pro Gly Ser 
    1325                 1330                 1335             


Asn Gly  Lys Pro Asn Gly Gln  Arg Ile Ile Asn Gly  Pro Gln Gly 
    1340                 1345                 1350             


Thr Lys  Trp Val Val Asp Leu  Asp Arg Gly Leu Val  Leu Asn Ala 
    1355                 1360                 1365             


Glu Gly  Arg Tyr Leu Gln Asp  Ser His Gly Asn Pro  Leu Arg Ile 
    1370                 1375                 1380             


Lys Leu  Gly Gly Asp Gly Arg  Thr Ile Val Asp Leu  Glu Gly Thr 
    1385                 1390                 1395             


Pro Val  Val Ser Pro Asp Gly  Leu Pro Leu Phe Gly  Gln Gly Arg 
    1400                 1405                 1410             


His Gly  Thr Pro Leu Ala Asn  Ala Gln Asp Lys Pro  Ile Leu Ser 
    1415                 1420                 1425             


Leu Gly  Gly Lys Pro Leu Val  Gly Leu Glu Val Ile  Lys Lys Thr 
    1430                 1435                 1440             


Thr His  Pro Pro Thr Thr Thr  Met Gln Pro Thr Thr  Thr Thr Thr 
    1445                 1450                 1455             


Pro Leu  Pro Thr Thr Thr Thr  Pro Arg Pro Thr Thr  Ala Thr Thr 
    1460                 1465                 1470             


Arg Arg  Thr Thr Thr Thr Arg  Arg Thr Thr Thr Arg  Arg Pro Thr 
    1475                 1480                 1485             


Thr Thr  Val Arg Thr Thr Thr  Arg Thr Thr Thr Thr  Thr Thr Pro 
    1490                 1495                 1500             


Thr Pro  Thr Thr Pro Ile Pro  Thr Cys Pro Pro Gly  Thr Leu Glu 
    1505                 1510                 1515             


Arg His  Asp Asp Asp Gly Asn  Leu Ile Met Ser Ser  Asn Gly Ile 
    1520                 1525                 1530             


Pro Glu  Cys Tyr Ala Glu Glu  Asp Glu Phe Ser Gly  Leu Glu Thr 
    1535                 1540                 1545             


Asp Thr  Ala Val Pro Thr Glu  Glu Ala Tyr Val Ile  Tyr Asp Glu 
    1550                 1555                 1560             


Asp Tyr  Glu Phe Glu Thr Ser  Arg Pro Pro Thr Thr  Thr Glu Pro 
    1565                 1570                 1575             


Ser Thr  Thr Ala Thr Thr Pro  Arg Val Ile Pro Glu  Glu Gly Ala 
    1580                 1585                 1590             


Ile Ser  Ser Phe Pro Glu Glu  Glu Phe Asp Leu Ala  Gly Arg Lys 
    1595                 1600                 1605             


Arg Phe  Val Ala Pro Tyr Val  Thr Tyr Leu Asn Lys  Asp Pro Ser 
    1610                 1615                 1620             


Ala Pro  Cys Ser Leu Thr Asp  Ala Leu Asp His Phe  Gln Val Asp 
    1625                 1630                 1635             


Ser Leu  Asp Glu Ile Ile Pro  Asn Asp Leu Lys Lys  Ser Asp Leu 
    1640                 1645                 1650             


Pro Pro  Gln His Ala Pro Arg  Asn Ile Thr Val Val  Ala Val Glu 
    1655                 1660                 1665             


Gly Cys  His Ser Phe Val Ile  Val Asp Trp Asp Lys  Ala Thr Pro 
    1670                 1675                 1680             


Gly Asp  Val Val Thr Gly Tyr  Leu Val Tyr Ser Ala  Ser Tyr Glu 
    1685                 1690                 1695             


Asp Phe  Ile Arg Asn Lys Trp  Ser Thr Gln Ala Ser  Ser Val Thr 
    1700                 1705                 1710             


His Leu  Pro Ile Glu Asn Leu  Lys Pro Asn Thr Arg  Tyr Tyr Phe 
    1715                 1720                 1725             


Lys Val  Gln Ala Gln Asn Pro  His Gly Tyr Gly Pro  Ile Ser Pro 
    1730                 1735                 1740             


Ser Val  Ser Phe Val Thr Glu  Ser Asp Asn Pro Leu  Leu Val Val 
    1745                 1750                 1755             


Arg Pro  Pro Gly Gly Glu Pro  Ile Trp Ile Pro Phe  Ala Phe Lys 
    1760                 1765                 1770             


His Asp  Pro Ser Tyr Thr Asp  Cys His Gly Arg Gln  Tyr Val Lys 
    1775                 1780                 1785             


Arg Thr  Trp Tyr Arg Lys Phe  Val Gly Val Val Leu  Cys Asn Ser 
    1790                 1795                 1800             


Leu Arg  Tyr Lys Ile Tyr Leu  Ser Asp Asn Leu Lys  Asp Thr Phe 
    1805                 1810                 1815             


Tyr Ser  Ile Gly Asp Ser Trp  Gly Arg Gly Glu Asp  His Cys Gln 
    1820                 1825                 1830             


Phe Val  Asp Ser His Leu Asp  Gly Arg Thr Gly Pro  Gln Ser Tyr 
    1835                 1840                 1845             


Val Glu  Ala Leu Pro Thr Ile  Gln Gly Tyr Tyr Arg  Gln Tyr Arg 
    1850                 1855                 1860             


Gln Glu  Pro Val Arg Phe Gly  Asn Ile Gly Phe Gly  Thr Pro Tyr 
    1865                 1870                 1875             


Tyr Tyr  Val Gly Trp Tyr Glu  Cys Gly Val Ser Ile  Pro Gly Lys 
    1880                 1885                 1890             


Trp 
    


<210>  39
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ala Asp Ile Ser Glu Ser Ser Gly Ala Asp Cys Lys Gly Asp 
1               5                   10                  15      


Pro Arg Asn Ser Ala Lys Leu Asp Ala Asp Tyr Pro Leu Arg Val Leu 
            20                  25                  30          


Tyr Cys Gly Val Cys Ser Leu Pro Thr Glu Tyr Cys Glu Tyr Met Pro 
        35                  40                  45              


Asp Val Ala Lys Cys Arg Gln Trp Leu Glu Lys Asn Phe Pro Asn Glu 
    50                  55                  60                  


Phe Ala Lys Leu Thr Val Glu Asn Ser Pro Lys Gln Glu Ala Gly Ile 
65                  70                  75                  80  


Ser Glu Gly Gln Gly Thr Ala Gly Glu Glu Glu Glu Lys Lys Lys Gln 
                85                  90                  95      


Lys Arg Gly Gly Arg Gly Gln Ile Lys Gln Lys Lys Lys Thr Val Pro 
            100                 105                 110         


Gln Lys Val Thr Ile Ala Lys Ile Pro Arg Ala Lys Lys Lys Tyr Val 
        115                 120                 125             


Thr Arg Val Cys Gly Leu Ala Thr Phe Glu Ile Asp Leu Lys Glu Ala 
    130                 135                 140                 


Gln Arg Phe Phe Ala Gln Lys Phe Ser Cys Gly Ala Ser Val Thr Gly 
145                 150                 155                 160 


Glu Asp Glu Ile Ile Ile Gln Gly Asp Phe Thr Asp Asp Ile Ile Asp 
                165                 170                 175     


Val Ile Gln Glu Lys Trp Pro Glu Val Asp Asp Asp Ser Ile Glu Asp 
            180                 185                 190         


Leu Gly Glu Val Lys Lys 
        195             


<210>  40
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 
        35                  40                  45              


Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 
    50                  55                  60                  


Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 
65                  70                  75                  80  


Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 
                85                  90                  95      


Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys 
            100                 105                 110         


Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly 
        115                 120                 125             


Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala 
    130                 135                 140                 


Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser 
                165                 170                 175     


Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly 
            180                 185                 190         


Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys 
        195                 200                 205             


Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met 
    210                 215                 220                 


Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala 
225                 230                 235                 240 


Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu 
                245                 250                 255     


Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe 
            260                 265         


<210>  41
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser 
1               5                   10                  15      


Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr 
            20                  25                  30          


Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala 
        35                  40                  45              


Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met 
    50                  55                  60                  


Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe 
65                  70                  75                  80  


Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu 
                85                  90                  95      


Lys Ala Val Pro Ser Gln Lys Arg Thr 
            100                 105 


<210>  42
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Lys Ser Lys Asn His Thr Thr His Asn Gln Ser Arg Lys Trp 
1               5                   10                  15      


His Arg Asn Gly Ile Lys Lys Pro Arg Ser Gln Arg Tyr Glu Ser Leu 
            20                  25                  30          


Lys Gly Val Asp Pro Lys Phe Leu Arg Asn Met Arg Phe Ala Lys Lys 
        35                  40                  45              


His Asn Lys Lys Gly Leu Lys Lys Met Gln Ala Asn Asn Ala Lys Ala 
    50                  55                  60                  


Met Ser Ala Arg Ala Glu Ala Ile Lys Ala Leu Val Lys Pro Lys Glu 
65                  70                  75                  80  


Val Lys Pro Lys Ile Pro Lys Gly Val Ser Arg Lys Leu Asp Arg Leu 
                85                  90                  95      


Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 
            100                 105                 110         


Ala Lys Gly Leu Arg Leu Cys Arg Pro Lys Ala Lys Ala Lys Ala Lys 
        115                 120                 125             


Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro 
    130                 135                 140                 


Ala Gln Ala Pro Lys Arg Thr Gln Ala Pro Thr Lys Ala Ser Glu 
145                 150                 155                 


<210>  43
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly 
1               5                   10                  15      


Arg Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly 
            20                  25                  30          


Thr Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg 
        35                  40                  45              


Tyr Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys 
    50                  55                  60                  


Arg Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu 
65                  70                  75                  80  


Met Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val 
                85                  90                  95      


Asn Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg 
            100                 105                 110         


Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys 
        115                 120                 125             


Trp Phe Phe Gln Lys Leu Arg Phe 
    130                 135     


<210>  44
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe 
1               5                   10                  15      


Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val 
            20                  25                  30          


Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile 
        35                  40                  45              


Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg 
    50                  55                  60                  


Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu 
65                  70                  75                  80  


Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu 
                85                  90                  95      


Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile 
            100                 105                 110         


Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg 
        115                 120                 125             


Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys 
    130                 135                 140                 


Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser 
145                 150                 155                 160 


Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp 
                165                 170                 175     


Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys 
            180                 185                 190         


Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu 
        195                 200                 205             


His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr 
    210                 215                 220                 


Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala 
225                 230                 235                 240 


Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu 
                245                 250                 255     


Asn 
    


<210>  45
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu 
1               5                   10                  15      


Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg 
            20                  25                  30          


Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp 
        35                  40                  45              


Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp 
    50                  55                  60                  


Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro 
                85                  90                  95      


Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly 
            100                 105                 110         


Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr 
    130                 135                 140                 


Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val 
                165                 170                 175     


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro 
            180                 185                 190         


Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser 
        195                 200                 205             


Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser 
    210                 215                 220     


<210>  46
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr 
1               5                   10                  15      


Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu 
            20                  25                  30          


Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg 
        35                  40                  45              


Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu 
    50                  55                  60                  


Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr 
65                  70                  75                  80  


Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu 
                85                  90                  95      


Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp 
            100                 105                 110         


Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln 
        115                 120                 125             


Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr 
    130                 135                 140                 


Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu 
145                 150                 155                 160 


Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr 
                165                 170                 175     


Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu 
            180                 185                 190         


Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His 
        195                 200                 205             


Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val 
    210                 215                 220                 


Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro 
225                 230                 235                 240 


Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly 
                245                 250                 255     


Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly 
            260                 265                 270         


His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His 
        275                 280                 285             


Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro 
    290                 295                 300                 


Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly 
305                 310                 315                 320 


His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg 
                325                 330                 335     


Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro 
            340                 345                 350         


Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met 
        355                 360                 365             


Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly 
    370                 375                 380                 


Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro 
385                 390                 395                 400 


Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly 
                405                 410                 415     


Pro Leu Arg Gly Pro Leu Pro Gln 
            420                 


<210>  47
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  47

Met His Leu Ala Arg Leu Val Gly Ser Cys Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Ala Leu Ser Gly Trp Ala Ala Ser Asp Asp Pro Ile Glu Lys Val 
            20                  25                  30          


Ile Glu Gly Ile Asn Arg Gly Leu Ser Asn Ala Glu Arg Glu Val Gly 
        35                  40                  45              


Lys Ala Leu Asp Gly Ile Asn Ser Gly Ile Thr His Ala Gly Arg Glu 
    50                  55                  60                  


Val Glu Lys Val Phe Asn Gly Leu Ser Asn Met Gly Ser His Thr Gly 
65                  70                  75                  80  


Lys Glu Leu Asp Lys Gly Val Gln Gly Leu Asn His Gly Met Asp Lys 
                85                  90                  95      


Val Ala His Glu Ile Asn His Gly Ile Gly Gln Ala Gly Lys Glu Ala 
            100                 105                 110         


Glu Lys Leu Gly His Gly Val Asn Asn Ala Ala Gly Gln Val Gly Lys 
        115                 120                 125             


Glu Ala Asp Lys Leu Ile His His Gly Val His His Gly Ala Asn Gln 
    130                 135                 140                 


Ala Gly Ser Glu Ala Gly Lys Phe Gly Gln Gly Val Asp Asn Ala Ala 
145                 150                 155                 160 


Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val His His 
                165                 170                 175     


Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val 
            180                 185                 190         


His His Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln 
        195                 200                 205             


Gly Ala His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe 
    210                 215                 220                 


Gly Gln Gly Ile His His Ala Ala Gly Gln Val Gly Lys Glu Ala Glu 
225                 230                 235                 240 


Lys Phe Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Asn Glu 
                245                 250                 255     


Ala Gly Arg Phe Gly Gln Gly Val His His Gly Leu Ser Glu Gly Trp 
            260                 265                 270         


Lys Glu Thr Glu Lys Phe Gly Gln Gly Val His His Thr Ala Gly Gln 
        275                 280                 285             


Val Gly Lys Glu Ala Glu Lys Phe Gly Gln Gly Ala His His Ala Ala 
    290                 295                 300                 


Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Ala His His 
305                 310                 315                 320 


Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val 
                325                 330                 335     


His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe Gly Gln 
            340                 345                 350         


Gly Val His His Ala Ala Ser Gln Phe Gly Lys Glu Thr Glu Lys Leu 
        355                 360                 365             


Gly His Gly Val His His Gly Val Asn Glu Ala Trp Lys Glu Ala Glu 
    370                 375                 380                 


Lys Phe Gly Gln Gly Val His His Ala Ala Ser Gln Val Gly Lys Glu 
385                 390                 395                 400 


Glu Asp Arg Val Val Gln Gly Leu His His Gly Val Ser Gln Ala Gly 
                405                 410                 415     


Arg Glu Ala Gly Gln Phe Gly His Asp Ile His His Thr Ala Gly Gln 
            420                 425                 430         


Ala Gly Lys Glu Gly Asp Ile Ala Val His Gly Val Gln Pro Gly Val 
        435                 440                 445             


His Glu Ala Gly Lys Glu Ala Gly Gln Phe Gly Gln Gly Val His His 
    450                 455                 460                 


Thr Leu Glu Gln Ala Gly Lys Glu Ala Asp Lys Ala Val Gln Gly Phe 
465                 470                 475                 480 


His Thr Gly Val His Gln Ala Gly Lys Glu Ala Glu Lys Leu Gly Gln 
                485                 490                 495     


Gly Val Asn His Ala Ala Asp Gln Ala Gly Lys Glu Val Glu Lys Leu 
            500                 505                 510         


Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Lys Glu Leu Gln 
        515                 520                 525             


Asn Ala His Asn Gly Val Asn Gln Ala Ser Lys Glu Ala Asn Gln Leu 
    530                 535                 540                 


Leu Asn Gly Asn His Gln Ser Gly Ser Ser Ser His Gln Gly Gly Ala 
545                 550                 555                 560 


Thr Thr Thr Pro Leu Ala Ser Gly Ala Ser Val Asn Thr Pro Phe Ile 
                565                 570                 575     


Asn Leu Pro Ala Leu Trp Arg Ser Val Ala Asn Ile Met Pro 
            580                 585                 590 


<210>  48
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile 
1               5                   10                  15      


Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser 
            20                  25                  30          


Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His 
        35                  40                  45              


Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu 
    50                  55                  60                  


Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys 
65                  70                  75                  80  


Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu 
                85                  90                  95      


Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala 
            100                 105                 110         


Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser 
        115                 120                 125             


Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu 
    130                 135                 140                 


Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn 
145                 150                 155                 160 


Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp 
                165                 170                 175     


Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys 
            180                 185                 190         


Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu 
        195                 200                 205             


Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys 
    210                 215                 220                 


Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu 
225                 230                 235                 240 


Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys 
                245                 250                 255     


Asp Ser Ala Ser Glu Glu Glu Ala His Val Gly Ala Gly Lys Arg Lys 
            260                 265                 270         


Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys 
        275                 280                 285             


Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro 
    290                 295                 300                 


Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys 
305                 310                 315                 320 


Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val 
                325                 330                 335     


Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu 
            340                 345                 350         


Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe 
        355                 360                 365             


Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys 
    370                 375                 


<210>  49
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala 
1               5                   10                  15      


Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe 
            20                  25                  30          


Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu 
        35                  40                  45              


Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln 
    50                  55                  60                  


Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu 
65                  70                  75                  80  


Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys 
                85                  90                  95      


Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala 
            100                 105                 110         


Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His 
        115                 120                 125             


Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp 
    130                 135                 140                 


Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys 
145                 150                 155                 160 


Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln 
                165                 170                 175     


Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg 
            180                 185                 190         


Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg 
        195                 200                 205             


Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn 
    210                 215                 220                 


Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val 
225                 230                 235                 240 


Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg 
                245                 250                 255     


Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu 
            260                 265                 270         


Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu 
        275                 280                 285             


Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser 
    290                 295                 300                 


Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His 
305                 310                 315                 320 


Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn 
                325                 330     


<210>  50
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro 
1               5                   10                  15      


Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro 
            20                  25                  30          


Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro 
        35                  40                  45              


Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly 
    50                  55                  60                  


Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu 
                85                  90                  95      


Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp 
            100                 105                 110         


Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys 
        115                 120                 125             


Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp 
    130                 135                 140                 


Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His 
145                 150                 155                 160 


Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg 
                165                 170                 175     


Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro 
            180                 185                 190         


His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu 
        195                 200                 205             


Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val 
    210                 215                 220                 


Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp 
225                 230                 235                 240 


Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg 
                245                 250                 255     


Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr 
            260                 265                 270         


Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp 
        275                 280                 285             


Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly 
    290                 295                 300                 


Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly 
305                 310                 315                 320 


Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala 
                325                 330                 335     


Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu 
            340                 345                 350         


Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys 
        355                 360                 365             


Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser 
    370                 375                 380                 


Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys 
385                 390                 395                 400 


Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr 
                405                 410                 415     


Ala Arg Gly Pro Ala Arg 
            420         


<210>  51
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  52
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  53
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  54
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 
1               5                   10                  15      


Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 
            20                  25                  30          


Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly 
        35                  40                  45              


Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly 
    50                  55                  60                  


Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys 
65                  70                  75                  80  


Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His 
                85                  90                  95      


Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu 
            100                 105                 110         


Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser 
        115                 120                 125             


Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln 
    130                 135                 140                 


Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn 
145                 150                 155                 160 


Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr 
                165                 170                 175     


Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly 
            180                 185                 190         


Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser 
        195                 200                 205             


Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile 
    210                 215                 220                 


Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr 
225                 230                 235                 240 


Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu 
                245                 250                 255     


Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe 
            260                 265                 270         


Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys 
        275                 280                 285             


Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile 
    290                 295                 300                 


Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys 
305                 310                 315                 320 


Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg 
                325                 330                 335     


Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala 
            340                 345                 350         


Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp 
        355                 360                 365             


Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile 
    370                 375                 380                 


Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala 
385                 390                 395                 400 


Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr 
                405                 410                 415     


Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn 
            420                 425                 430         


Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp 
        435                 440                 445             


Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val 
    450                 455                 460                 


Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile 
465                 470                 475                 480 


Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu 
                485                 490                 495     


Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe 
            500                 505                 


<210>  55
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser 
1               5                   10                  15      


Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu 
            20                  25                  30          


Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln 
        35                  40                  45              


Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg 
    50                  55                  60                  


Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro 
65                  70                  75                  80  


Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly 
                85                  90                  95      


Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu 
            100                 105                 110         


Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp 
        115                 120                 125             


Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys 
    130                 135                 140                 


Glu Glu Lys Pro Ser Val Ser Lys Glu Glu Lys Pro Ser Val Ser Lys 
145                 150                 155                 160 


Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys 
                165                 170                 175     


Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg 
            180                 185                 190         


Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser 
        195                 200                 205             


Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu 
    210                 215                 220                 


Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly 
225                 230                 235                 240 


Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys 
                245                 250                 255     


Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp 
            260                 265                 270         


Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp 
        275                 280                 285             


Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu 
    290                 295                 300                 


Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp 
305                 310                 315                 320 


Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu 
                325                 330                 335     


Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu 
            340                 345                 350         


His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr 
        355                 360                 365             


Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly 
    370                 375                 380                 


Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg 
385                 390                 395                 400 


Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly 
                405                 410                 415     


Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys 
            420                 425                 430         


Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile 
        435                 440                 445             


Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu 
    450                 455                 460                 


Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala 
465                 470                 475                 480 


Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg 
                485                 490                 495     


Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly 
            500                 505                 510         


Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala 
        515                 520                 525             


Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser 
    530                 535                 540                 


Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp 
545                 550                 555                 560 


Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala 
                565                 570                 575     


Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly 
            580                 585                 590         


Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile 
        595                 600                 605             


Glu Gly Lys Lys Asn Ser Leu Arg Val Glu Gly Asp Asn Ile Tyr Val 
    610                 615                 620                 


Arg His Ser Asn Leu Met Leu Glu Glu Leu Asp Lys Ala Gln Glu Asp 
625                 630                 635                 640 


Ile Leu Lys His Gln Ala Ser Ile Ser Glu Leu Lys Arg Asn Phe Met 
                645                 650                 655     


Glu Ser Thr Pro Glu Pro Arg Pro Asn Glu Trp Glu Lys Arg Arg Ile 
            660                 665                 670         


Thr Pro Leu Ser Leu Gln Thr Gln Gly Ser Ser His Glu Thr Leu Asn 
        675                 680                 685             


Ile Val Glu Glu Lys Lys Arg Ala Glu Val Gly Lys Asp Glu Arg Val 
    690                 695                 700                 


Ile Thr Glu Glu Met Asn Gly Lys Glu Ile Ser Pro Gly Ser Gly Pro 
705                 710                 715                 720 


Gly Glu Ile Arg Lys Val Glu Pro Val Thr Gln Lys Asp Ser Thr Ser 
                725                 730                 735     


Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Glu Glu Glu Asp 
            740                 745                 750         


Val Gly Glu Tyr Arg Pro His His Arg Val Thr Glu Gly Thr Ile Arg 
        755                 760                 765             


Glu Glu Gln Glu Tyr Glu Glu Glu Val Glu Glu Glu Pro Arg Pro Ala 
    770                 775                 780                 


Ala Lys Val Val Glu Arg Glu Glu Ala Val Pro Glu Ala Ser Pro Val 
785                 790                 795                 800 


Thr Gln Ala Gly Ala Ser Val Ile Thr Val Glu Thr Val Ile Gln Glu 
                805                 810                 815     


Asn Val Gly Ala Gln Lys Ile Pro Gly Glu Lys Ser Val His Glu Gly 
            820                 825                 830         


Ala Leu Lys Gln Asp Met Gly Glu Glu Ala Glu Glu Glu Pro Gln Lys 
        835                 840                 845             


Val Asn Gly Glu Val Ser His Val Asp Ile Asp Val Leu Pro Gln Ile 
    850                 855                 860                 


Ile Cys Cys Ser Glu Pro Pro Val Val Lys Thr Glu Met Val Thr Ile 
865                 870                 875                 880 


Ser Asp Ala Ser Gln Arg Thr Glu Ile Ser Thr Lys Glu Val Pro Ile 
                885                 890                 895     


Val Gln Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Pro Gln Ile Asp 
            900                 905                 910         


Gly Gly Ala Gly Gly Asp Ser Gly Thr Leu Leu Thr Ala Gln Thr Ile 
        915                 920                 925             


Thr Ser Glu Ser Val Ser Thr Thr Thr Thr Thr His Ile Thr Lys Thr 
    930                 935                 940                 


Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile 
945                 950                 955                 960 


Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala Ile 
                965                 970                 975     


Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val Thr Arg Val Val 
            980                 985                 990         


Val His Lys Glu Thr Glu Leu Ala  Glu Glu Gly Glu Asp  
        995                 1000                 1005 


<210>  56
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu 
1               5                   10                  15      


Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val 
            20                  25                  30          


Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn 
        35                  40                  45              


Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala 
    50                  55                  60                  


Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala 
65                  70                  75                  80  


Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val 
                85                  90                  95      


Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu 
            100                 105                 110         


Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly 
        115                 120                 125             


Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe 
    130                 135                 140                 


Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala 
145                 150                 155                 160 


Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr 
                165                 170                 175     


Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val 
            180                 185                 190         


Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile 
        195                 200                 205             


Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu 
    210                 215                 


<210>  57
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser 
1               5                   10                  15      


Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His 
            20                  25                  30          


Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser 
        35                  40                  45              


Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala 
    50                  55                  60                  


Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp 
65                  70                  75                  80  


Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys 
                85                  90                  95      


Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala 
            100                 105                 110         


Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg 
        115                 120                 125             


Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly 
    130                 135                 140                 


Gly Arg Arg Gly Arg Arg Leu 
145                 150     


<210>  58
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Pro Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala Pro 
1               5                   10                  15      


Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe 
            20                  25                  30          


Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys 
        35                  40                  45              


Arg Asp Leu Thr Arg Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln 
    50                  55                  60                  


Arg Gln Arg Ala Ile Leu Tyr Lys Arg Leu Lys Val Pro Pro Ala Ile 
65                  70                  75                  80  


Asn Gln Phe Thr Gln Ala Leu Asp Arg Gln Thr Ala Thr Gln Leu Leu 
                85                  90                  95      


Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Gln 
            100                 105                 110         


Arg Leu Leu Ala Arg Ala Glu Lys Lys Ala Ala Gly Lys Gly Asp Val 
        115                 120                 125             


Pro Thr Lys Arg Pro Pro Val Leu Arg Ala Gly Val Asn Thr Val Thr 
    130                 135                 140                 


Thr Leu Val Glu Asn Lys Lys Ala Gln Leu Val Val Ile Ala His Asp 
145                 150                 155                 160 


Val Asp Pro Ile Glu Leu Val Val Phe Leu Pro Ala Leu Cys Arg Lys 
                165                 170                 175     


Met Gly Val Pro Tyr Cys Ile Ile Lys Gly Lys Ala Arg Leu Gly Arg 
            180                 185                 190         


Leu Val His Arg Lys Thr Cys Thr Thr Val Ala Phe Thr Gln Val Asn 
        195                 200                 205             


Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile Arg Thr 
    210                 215                 220                 


Asn Tyr Asn Asp Arg Tyr Asp Glu Ile Arg Arg His Trp Gly Gly Asn 
225                 230                 235                 240 


Val Leu Gly Pro Lys Ser Val Ala Arg Ile Ala Lys Leu Glu Lys Ala 
                245                 250                 255     


Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly 
            260                 265     


<210>  59
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  60
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser 
            980                 985                 990         


Val Val Pro Ala Pro Ala Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Ser Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Gln  Gln Pro Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Gln  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Gly  Asn Ala Pro Leu Gly  Leu Pro Phe 
    1070                 1075                 1080             


Gly Met  Pro Pro Pro Pro Pro  Pro Pro Ala Pro Ser  Ile Ile Pro 
    1085                 1090                 1095             


Phe Gly  Ser Leu Ala Asp Ser  Ile Ser Ile Asn Leu  Pro Ala Pro 
    1100                 1105                 1110             


Pro Asn  Leu His Gly His His  His His Leu Pro Phe  Ala Pro Gly 
    1115                 1120                 1125             


Thr Leu  Pro Pro Pro Asn Leu  Pro Val Ser Met Ala  Asn Pro Leu 
    1130                 1135                 1140             


His Pro  Asn Leu Pro Ala Thr  Thr Thr Met Pro Ser  Ser Leu Pro 
    1145                 1150                 1155             


Leu Gly  Pro Gly Leu Gly Ser  Ala Ala Ala Gln Ser  Pro Ala Ile 
    1160                 1165                 1170             


Val Ala  Ala Val Gln Gly Asn  Leu Leu Pro Ser Ala  Ser Pro Leu 
    1175                 1180                 1185             


Pro Asp  Pro Gly Thr Pro Leu  Pro Pro Asp Pro Thr  Ala Pro Ser 
    1190                 1195                 1200             


Pro Gly  Thr Val Thr Pro Val  Pro Pro Pro Gln 
    1205                 1210                 


<210>  61
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln 
1               5                   10                  15      


Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln 
            20                  25                  30          


Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly 
        35                  40                  45              


Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu 
    50                  55                  60                  


Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile 
65                  70                  75                  80  


Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr 
        115                 120                 125             


Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe 
    130                 135                 140                 


Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg 
145                 150                 155                 160 


Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
            180                 185                 190         


Gly Met Pro Arg Gln Ile Leu 
        195                 


<210>  62
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala 
1               5                   10                  15      


Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln 
            20                  25                  30          


Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly 
    50                  55                  60                  


Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln 
65                  70                  75                  80  


Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys 
                85                  90                  95      


Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
            100                 105                 110         


Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile 
        115                 120                 125             


His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly 
    130                 135                 140                 


Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val 
                165                 170                 175     


Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met 
            180                 185                 190         


Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile 
        195                 200                 205             


Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val 
    210                 215                 220                 


Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg 
225                 230                 235                 240 


Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro 
                245                 250                 255     


Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met 
            260                 265                 270         


Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys 
        275                 280                 285             


Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile 
    290                 295                 300                 


Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met 
305                 310                 315                 320 


Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile 
                325                 330                 335     


Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr 
            340                 345                 350         


Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn 
        355                 360                 365             


Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys 
    370                 375                 380                 


Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu 
385                 390                 395                 400 


Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val 
                405                 410                 415     


Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu 
            420                 425                 430         


Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser 
        435                 440                 445             


Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr 
    450                 455                 460                 


Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu 
465                 470                 475                 480 


Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg 
                485                 490                 495     


Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu 
            500                 505                 510         


Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser 
        515                 520                 525             


Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg 
    530                 535                 


<210>  63
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 
                245                 250                 255     


Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 
            260                 265                 270         


Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 
        275                 280                 285             


Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 
    290                 295                 300                 


Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro 
305                 310                 315                 320 


Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys 
                325                 330                 335     


Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg 
            340                 345                 350         


Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val 
        355                 360                 365             


Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys 
    370                 375                 380                 


Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly 
385                 390                 395                 400 


Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala 
                405                 410                 415     


Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe 
            420                 425                 430         


Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln 
        435                 440                 445             


Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr 
    450                 455                 460                 


Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val 
465                 470                 475                 480 


Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe 
                485                 490                 495     


Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys 
            500                 505                 510         


Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 
        515                 520                 525             


Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr 
    530                 535                 540                 


Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp 
545                 550                 555                 560 


Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp 
                565                 570                 575     


Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg 
            580                 585                 590         


Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala 
        595                 600                 605             


Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp 
    610                 615                 620                 


Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala 
625                 630                 635                 640 


Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu 
                645                 650                 655     


Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro 
            660                 665                 670         


Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg 
        675                 680                 685             


Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys 
    690                 695                 700                 


Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp 
705                 710                 715                 720 


Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu 
                725                 730                 735     


Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg 
            740                 745                 750         


Arg Ser Leu Pro Ala Ile 
        755             


<210>  64
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Pro Leu Pro Val Gln Val Phe Asn Leu Gln Gly Ala Val Glu Pro 
1               5                   10                  15      


Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp 
            20                  25                  30          


Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala 
        35                  40                  45              


Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala 
    50                  55                  60                  


Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser 
65                  70                  75                  80  


Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg 
                85                  90                  95      


Lys Leu Ser Glu Ala Thr Arg Ser Ser Leu Arg Glu Leu Gln Asn Ala 
            100                 105                 110         


Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr 
        115                 120                 125             


Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys 
    130                 135                 140                 


Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser 
145                 150                 155                 160 


Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly 
                165                 170                 175     


Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys 
            180                 185                 190         


Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val 
        195                 200                 205             


Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys 
    210                 215                 220                 


Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser 
225                 230                 235                 240 


Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala 
                245                 250                 255     


Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu 
            260                 265                 270         


Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn 
        275                 280                 285             


Val Ala Ile Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln 
    290                 295                 300                 


Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu 
305                 310                 315                 320 


Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser 
                325                 330                 335     


Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu 
            340                 345                 350         


Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln 
        355                 360                 365             


Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala 
    370                 375                 380                 


Asp Met His Arg Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu 
385                 390                 395                 400 


Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg 
                405                 410                 415     


Val Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg 
            420                 425                 430         


Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg 
        435                 440                 445             


Arg Ala Lys Ala Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile 
    450                 455                 460                 


His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro 
465                 470                 475                 480 


Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met 
                485                 490     


<210>  65
<211>  1512
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser 
1               5                   10                  15      


Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu 
            20                  25                  30          


Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu 
        35                  40                  45              


Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro 
    50                  55                  60                  


Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys 
65                  70                  75                  80  


Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys 
                85                  90                  95      


Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly 
            100                 105                 110         


Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln 
        115                 120                 125             


Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val 
    130                 135                 140                 


Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu 
            180                 185                 190         


Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg 
        195                 200                 205             


Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly 
    210                 215                 220                 


Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu 
225                 230                 235                 240 


Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly 
                245                 250                 255     


Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys 
            260                 265                 270         


Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu 
        275                 280                 285             


Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys 
    290                 295                 300                 


Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly 
305                 310                 315                 320 


Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg 
                325                 330                 335     


Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser 
            340                 345                 350         


Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro 
        355                 360                 365             


Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro 
    370                 375                 380                 


Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser 
385                 390                 395                 400 


Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser 
                405                 410                 415     


Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg 
            420                 425                 430         


Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser 
        435                 440                 445             


Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala 
    450                 455                 460                 


Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala 
465                 470                 475                 480 


Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr 
                485                 490                 495     


Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val 
            500                 505                 510         


Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser 
        515                 520                 525             


Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln 
    530                 535                 540                 


Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu 
                565                 570                 575     


Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly 
            580                 585                 590         


Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro 
        595                 600                 605             


Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser 
    610                 615                 620                 


Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys 
625                 630                 635                 640 


Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro 
                645                 650                 655     


Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr 
            660                 665                 670         


Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly 
        675                 680                 685             


Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys 
    690                 695                 700                 


Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr 
705                 710                 715                 720 


Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val 
                725                 730                 735     


Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu 
            740                 745                 750         


Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys 
        755                 760                 765             


Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys 
    770                 775                 780                 


Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly 
785                 790                 795                 800 


Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser 
                805                 810                 815     


Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn 
            820                 825                 830         


Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg 
        835                 840                 845             


Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser 
    850                 855                 860                 


Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg 
865                 870                 875                 880 


Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp 
                885                 890                 895     


Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro 
            900                 905                 910         


Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg 
        915                 920                 925             


Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu 
    930                 935                 940                 


Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu 
945                 950                 955                 960 


Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp 
                965                 970                 975     


Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala 
            980                 985                 990         


Leu Gln Cys Glu Phe Leu Arg Asp  Val Glu Pro Ser Lys  Met Pro Pro 
        995                 1000                 1005             


Pro Asp  Leu Pro Leu Trp Gln  Asp Cys His Glu Leu  Trp Ser Lys 
    1010                 1015                 1020             


Lys Arg  Arg Arg Gln Lys Gln  Met Gly Met Thr Asp  Asp Val Ser 
    1025                 1030                 1035             


Thr Ile  Lys Ala Pro Arg Lys  Asp Leu Ser Leu Gly  Leu Asp Asp 
    1040                 1045                 1050             


Ser Arg  Thr Asn Thr Pro Gln  Gly Val Leu Pro Ser  Ser Gln Leu 
    1055                 1060                 1065             


Lys Ser  Gln Gly Ser Ser Asn  Val Ala Pro Val Lys  Thr Gly Pro 
    1070                 1075                 1080             


Gly Gln  His Leu Asn His Ser  Glu Leu Ala Ile Leu  Leu Asn Leu 
    1085                 1090                 1095             


Leu Gln  Ser Lys Thr Ser Val  Asn Met Ala Asp Phe  Val Gln Val 
    1100                 1105                 1110             


Leu Asn  Ile Lys Val Asn Ser  Glu Thr Gln Gln Gln  Leu Asn Lys 
    1115                 1120                 1125             


Ile Asn  Leu Pro Ala Gly Ile  Leu Ala Thr Gly Glu  Lys Gln Thr 
    1130                 1135                 1140             


Asp Pro  Ser Thr Pro Gln Gln  Glu Ser Ser Lys Pro  Leu Gly Gly 
    1145                 1150                 1155             


Ile Gln  Pro Ser Ser Gln Thr  Ile Gln Pro Lys Val  Glu Thr Asp 
    1160                 1165                 1170             


Ala Ala  Gln Ala Ala Val Gln  Ser Ala Phe Ala Val  Leu Leu Thr 
    1175                 1180                 1185             


Gln Leu  Ile Lys Ala Gln Gln  Ser Lys Gln Lys Asp  Val Leu Leu 
    1190                 1195                 1200             


Glu Glu  Arg Glu Asn Gly Ser  Gly His Glu Ala Ser  Leu Gln Leu 
    1205                 1210                 1215             


Arg Pro  Pro Pro Glu Pro Ser  Thr Pro Val Ser Gly  Gln Asp Asp 
    1220                 1225                 1230             


Leu Ile  Gln His Gln Asp Met  Arg Ile Leu Glu Leu  Thr Pro Glu 
    1235                 1240                 1245             


Pro Asp  Arg Pro Arg Ile Leu  Pro Pro Asp Gln Arg  Pro Pro Glu 
    1250                 1255                 1260             


Pro Pro  Glu Pro Pro Pro Val  Thr Glu Glu Asp Leu  Asp Tyr Arg 
    1265                 1270                 1275             


Thr Glu  Asn Gln His Val Pro  Thr Thr Ser Ser Ser  Leu Thr Asp 
    1280                 1285                 1290             


Pro His  Ala Gly Val Lys Ala  Ala Leu Leu Gln Leu  Leu Ala Gln 
    1295                 1300                 1305             


His Gln  Pro Gln Asp Asp Pro  Lys Arg Glu Gly Gly  Ile Asp Tyr 
    1310                 1315                 1320             


Gln Ala  Gly Asp Thr Tyr Val  Ser Thr Ser Asp Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Phe Gly  Ser Ser Ser Phe Ser  Ser Ala Pro Tyr Val  Ser Asn Asp 
    1340                 1345                 1350             


Gly Leu  Gly Ser Ser Ser Ala  Pro Pro Leu Glu Arg  Arg Ser Phe 
    1355                 1360                 1365             


Ile Gly  Asn Ser Asp Ile Gln  Ser Leu Asp Asn Tyr  Ser Thr Ala 
    1370                 1375                 1380             


Ser Ser  His Ser Gly Gly Pro  Pro Gln Pro Ser Ala  Phe Ser Glu 
    1385                 1390                 1395             


Ser Phe  Pro Ser Ser Val Ala  Gly Tyr Gly Asp Ile  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Gly  Pro Met Leu Phe Ser  Gly Asp Lys Asp His  Arg Phe Glu 
    1415                 1420                 1425             


Tyr Ser  His Gly Pro Ile Ala  Val Leu Ala Asn Ser  Ser Asp Pro 
    1430                 1435                 1440             


Ser Thr  Gly Pro Glu Ser Thr  His Pro Leu Pro Ala  Lys Met His 
    1445                 1450                 1455             


Asn Tyr  Asn Tyr Gly Gly Asn  Leu Gln Glu Asn Pro  Ser Gly Pro 
    1460                 1465                 1470             


Ser Leu  Met His Gly Gln Thr  Trp Thr Ser Pro Ala  Gln Gly Pro 
    1475                 1480                 1485             


Gly Tyr  Ser Gln Gly Tyr Arg  Gly His Ile Ser Thr  Ser Thr Gly 
    1490                 1495                 1500             


Arg Gly  Arg Gly Arg Gly Leu  Pro Tyr 
    1505                 1510         


<210>  66
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys 
1               5                   10                  15      


Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp 
            20                  25                  30          


Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met 
        35                  40                  45              


Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser 
    50                  55                  60                  


Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln 
65                  70                  75                  80  


Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala 
                85                  90                  95      


Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro 
            100                 105                 110         


Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys 
        115                 120                 125             


Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln 
    130                 135                 140                 


Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys 
145                 150                 155                 160 


Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly 
                165                 170                 175     


Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu 
            180                 185                 190         


Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp 
        195                 200                 205             


Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu 
    210                 215                 220                 


Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu 
225                 230                 235                 240 


Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln 
                245                 250                 255     


Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln 
            260                 265                 270         


Pro Asn Gly Gly Leu Ser His Thr Gly Thr Pro Lys Pro Ser Gly Val 
        275                 280                 285             


Gln Met Asp Gln Pro Cys Cys Arg Ala Leu Tyr Asp Phe Glu Pro Glu 
    290                 295                 300                 


Asn Glu Gly Glu Leu Gly Phe Lys Glu Gly Asp Ile Ile Thr Leu Thr 
305                 310                 315                 320 


Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu His Gly His Ser 
                325                 330                 335     


Gly Phe Phe Pro Ile Asn Tyr Val Glu Ile Leu Val Ala Leu Pro His 
            340                 345                 350         


<210>  67
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  68
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu 
1               5                   10                  15      


Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys 
            20                  25                  30          


Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro 
        35                  40                  45              


Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile 
    50                  55                  60                  


Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly 
65                  70                  75                  80  


Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu 
                85                  90                  95      


Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro 
            100                 105                 110         


Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr 
        115                 120                 125             


Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr 
    130                 135                 140                 


Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala 
145                 150                 155                 160 


Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly 
                165                 170                 175     


Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe 
            180                 185                 190         


Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys 
        195                 200                 205             


Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys 
    210                 215                 220                 


Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe 
225                 230                 235                 240 


Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu 
                245                 250                 255     


Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn 
            260                 265                 270         


Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser 
        275                 280                 285             


His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala 
    290                 295                 300                 


Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu 
305                 310                 315             


<210>  69
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 
1               5                   10                  15      


Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 
            20                  25                  30          


Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 
        35                  40                  45              


Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 
    50                  55                  60                  


Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 
                85                  90                  95      


Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 
            100                 105                 110         


Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 
        115                 120                 125             


Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 
    130                 135                 140                 


Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 
145                 150                 155                 160 


Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu 
                165                 170                 175     


Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val 
            180                 185                 190         


Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val 
        195                 200                 205             


Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr 
    210                 215                 220                 


Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu 
225                 230                 235                 240 


Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu 
                245                 250                 255     


Lys Tyr Ser Gly Ser Thr Pro 
            260             


<210>  70
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 
1               5                   10                  15      


Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 
            20                  25                  30          


Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 
        35                  40                  45              


Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp 
    50                  55                  60                  


Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe 
65                  70                  75                  80  


Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 
                85                  90                  95      


Leu Glu Ala Thr Ile Asn Glu Leu Val 
            100                 105 


<210>  71
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  72
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly 
1               5                   10                  15      


Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro 
            20                  25                  30          


Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val 
        35                  40                  45              


Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn 
    50                  55                  60                  


Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp 
65                  70                  75                  80  


Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu 
                85                  90                  95      


Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp 
            100                 105                 110         


Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys 
        115                 120                 125             


Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser 
145                 150                 155                 160 


Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala 
                165                 170                 175     


Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly 
            180                 185                 190         


Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys 
        195                 200                 205             


<210>  73
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Pro Gln Lys Lys Lys Pro 
1               5                   10                  15      


Arg Pro Pro Pro Ala Leu Gly Pro Glu Glu Thr Ser Ala Ser Ala Gly 
            20                  25                  30          


Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile 
        35                  40                  45              


Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Ala Ser Glu 
    50                  55                  60                  


Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe 
65                  70                  75                  80  


Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Trp Val 
                85                  90                  95      


Thr Thr Phe Val Asn His Pro Gln Val Ser Ala Leu Leu Gly Glu Glu 
            100                 105                 110         


Asp Glu Glu Ala Leu His Tyr Leu Thr Arg Val Glu Val Thr Glu Phe 
        115                 120                 125             


Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn 
    130                 135                 140                 


Pro Tyr Phe Glu Asn Lys Val Leu Ser Lys Glu Phe His Leu Asn Glu 
145                 150                 155                 160 


Ser Gly Asp Pro Ser Ser Lys Ser Thr Glu Ile Lys Trp Lys Ser Gly 
                165                 170                 175     


Lys Asp Leu Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg 
            180                 185                 190         


Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp 
        195                 200                 205             


His Ser Asp Ala Gly Ala Asp Glu Leu Gly Glu Val Ile Lys Asp Asp 
    210                 215                 220                 


Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp 
225                 230                 235                 240 


Glu Glu Gly Glu Gly Glu Glu Asp Asp Asp Asp Asp Glu Glu Glu Glu 
                245                 250                 255     


Gly Leu Glu Asp Ile Asp Glu Glu Gly Asp Glu Asp Glu Gly Glu Glu 
            260                 265                 270         


Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu Gly Glu 
        275                 280                 285             


Asp Asp 
    290 


<210>  74
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu 
1               5                   10                  15      


Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala 
            20                  25                  30          


Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala 
        35                  40                  45              


Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val 
    50                  55                  60                  


Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro 
65                  70                  75                  80  


Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser 
                85                  90                  95      


Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu 
            100                 105                 110         


Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly 
        115                 120                 125             


Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg 
    130                 135                 140                 


Thr Val Gly Val Ser Lys Lys Lys 
145                 150         


<210>  75
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  76
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 
            340                 345                 350         


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
        355                 360                 365             


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro 
    370                 375                 380                 


Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys 
385                 390                 395                 400 


Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp 
                405                 410                 415     


Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn 
            420                 425                 430         


Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 
        435                 440                 445             


Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg 
    450                 455                 460                 


Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
465                 470                 475     


<210>  77
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys 
1               5                   10                  15      


Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly 
            20                  25                  30          


Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys 
        35                  40                  45              


Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu 
    50                  55                  60                  


Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys 
65                  70                  75                  80  


Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu 
                85                  90                  95      


Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu 
            100                 105                 110         


Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp 
        115                 120                 125             


<210>  78
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Gly Glu Lys Val Glu Lys Pro Asp Thr Lys Glu Lys Lys Pro 
1               5                   10                  15      


Glu Ala Lys Lys Val Asp Ala Gly Gly Lys Val Lys Lys Gly Asn Leu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Gly Lys Pro His Cys Ser Arg Asn Pro 
        35                  40                  45              


Val Leu Val Arg Gly Ile Gly Arg Tyr Ser Arg Ser Ala Met Tyr Ser 
    50                  55                  60                  


Arg Lys Ala Met Tyr Lys Arg Lys Tyr Ser Ala Ala Lys Ser Lys Val 
65                  70                  75                  80  


Glu Lys Lys Lys Lys Glu Lys Val Leu Ala Thr Val Thr Lys Pro Val 
                85                  90                  95      


Gly Gly Asp Lys Asn Gly Gly Thr Arg Val Val Lys Leu Arg Lys Met 
            100                 105                 110         


Pro Arg Tyr Tyr Pro Thr Glu Asp Val Pro Arg Lys Leu Leu Ser His 
        115                 120                 125             


Gly Lys Lys Pro Phe Ser Gln His Val Arg Lys Leu Arg Ala Ser Ile 
    130                 135                 140                 


Thr Pro Gly Thr Ile Leu Ile Ile Leu Thr Gly Arg His Arg Gly Lys 
145                 150                 155                 160 


Arg Val Val Phe Leu Lys Gln Leu Ala Ser Gly Leu Leu Leu Val Thr 
                165                 170                 175     


Gly Pro Leu Val Leu Asn Arg Val Pro Leu Arg Arg Thr His Gln Lys 
            180                 185                 190         


Phe Val Ile Ala Thr Ser Thr Lys Ile Asp Ile Ser Asn Val Lys Ile 
        195                 200                 205             


Pro Lys His Leu Thr Asp Ala Tyr Phe Lys Lys Lys Lys Leu Arg Lys 
    210                 215                 220                 


Pro Arg His Gln Glu Gly Glu Ile Phe Asp Thr Glu Lys Glu Lys Tyr 
225                 230                 235                 240 


Glu Ile Thr Glu Gln Arg Lys Ile Asp Gln Lys Ala Val Asp Ser Gln 
                245                 250                 255     


Ile Leu Pro Lys Ile Lys Ala Ile Pro Gln Leu Gln Gly Tyr Leu Arg 
            260                 265                 270         


Ser Val Phe Ala Leu Thr Asn Gly Ile Tyr Pro His Lys Leu Val Phe 
        275                 280                 285             


<210>  79
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 
                85                  90                  95      


Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 
            100                 105                 110         


Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 
        115                 120                 125             


Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 
    130                 135                 140                 


Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 
145                 150                 155                 160 


Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe 
                165                 170                 175     


Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp 
            180                 185                 190         


Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly 
        195                 200                 205             


Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly 
    210                 215                 220                 


Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys 
225                 230                 235                 240 


Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val 
                245                 250                 255     


Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr 
            260                 265                 270         


Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe 
        275                 280                 285             


Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp 
    290                 295                 300                 


Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly 
305                 310                 315                 320 


Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly 
                325                 330                 335     


Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn 
            340                 345                 350         


Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val 
        355                 360                 365             


His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr 
    370                 375                 380                 


Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp 
385                 390                 395                 400 


Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu 
                405                 410                 415     


Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala 
            420                 425                 430         


Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val 
        435                 440                 445             


Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu 
    450                 455                 460                 


Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val 
465                 470                 475                 480 


Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val 
                485                 490                 495     


Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn 
            500                 505                 510         


Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala 
        515                 520                 525             


Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu 
    530                 535                 540                 


Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly 
545                 550                 555                 560 


Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu 
                565                 570                 575     


Arg Val His Glu Glu Leu 
            580         


<210>  80
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala 
1               5                   10                  15      


Asp Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys 
            20                  25                  30          


Lys Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala 
        35                  40                  45              


Gly Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys 
    50                  55                  60                  


Val Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr 
65                  70                  75                  80  


Ser Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro 
                85                  90                  95      


Arg Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr 
            100                 105                 110         


Arg Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu 
        115                 120                 125             


Asp Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg 
    130                 135                 140                 


Thr Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His 
145                 150                 155                 160 


Ser Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu 
                165                 170                 175     


Trp Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp 
            180                 185                 190         


His Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val 
        195                 200                 205             


Ser Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly 
    210                 215                 220                 


Tyr Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val 
225                 230                 235                 240 


Arg Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln 
                245                 250                 255     


Thr Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu 
            260                 265                 270         


Arg Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser 
        275                 280                 285             


Ser Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser 
    290                 295                 300                 


Gly Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile 
305                 310                 315                 320 


Lys Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly 
                325                 330                 335     


His Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe 
            340                 345                 350         


Ile Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys 
        355                 360                 365             


Asn Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr 
    370                 375                 380                 


Ser Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val 
385                 390                 395                 400 


Asp Gln Thr Val Lys Val Trp Glu Cys Arg 
                405                 410 


<210>  81
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Ala Glu Pro Leu Thr Glu Leu Glu Glu Ser Ile Glu Thr Val 
1               5                   10                  15      


Val Thr Thr Phe Phe Thr Phe Ala Arg Gln Glu Gly Arg Lys Asp Ser 
            20                  25                  30          


Leu Ser Val Asn Glu Phe Lys Glu Leu Val Thr Gln Gln Leu Pro His 
        35                  40                  45              


Leu Leu Lys Asp Val Gly Ser Leu Asp Glu Lys Met Lys Ser Leu Asp 
    50                  55                  60                  


Val Asn Gln Asp Ser Glu Leu Lys Phe Asn Glu Tyr Trp Arg Leu Ile 
65                  70                  75                  80  


Gly Glu Leu Ala Lys Glu Ile Arg Lys Lys Lys Asp Leu Lys Ile Arg 
                85                  90                  95      


Lys Lys 
        


<210>  82
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe 
1               5                   10                  15      


Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile 
            20                  25                  30          


Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala 
        35                  40                  45              


Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser 
    50                  55                  60                  


Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met 
65                  70                  75                  80  


Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr 
                85                  90                  95      


Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp 
            100                 105                 110         


Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn 
        115                 120                 125             


Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp 
    130                 135                 140                 


Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr 
145                 150                 155                 160 


Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr 
                165                 170                 175     


Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu 
            180                 185                 190         


Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile 
        195                 200                 205             


Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn 
    210                 215                 220                 


Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val 
225                 230                 235                 240 


Ala Leu Ala Glu Arg Asp 
                245     


<210>  83
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  84
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Ser Ala Thr Ser His Ser Gly Ser Gly Ser Lys Ser Ser Gly 
1               5                   10                  15      


Pro Pro Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala 
            20                  25                  30          


Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala 
        35                  40                  45              


Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys 
    50                  55                  60                  


Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu 
65                  70                  75                  80  


Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val 
                85                  90                  95      


Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu 
            100                 105                 110         


Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys 
        115                 120                 125             


Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys 
    130                 135                 140                 


Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly 
145                 150                 155                 160 


Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro 
                165                 170                 175     


Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu 
            180                 185                 190         


Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu 
        195                 200                 205             


His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro 
    210                 215                 220                 


Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val 
225                 230                 235                 240 


Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu 
                245                 250                 255     


Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val 
            260                 265                 270         


Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu 
        275                 280                 285             


Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln 
    290                 295                 300                 


Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr 
305                 310                 315                 320 


Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro 
                325                 330                 335     


Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro 
            340                 345                 350         


Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly 
        355                 360                 365             


Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr 
    370                 375                 380                 


Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn 
385                 390                 395                 400 


Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg 
                405                 410                 415     


Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val 
            420                 425                 430         


Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu 
        435                 440                 445             


Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile 
    450                 455                 460                 


Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala 
465                 470                 475                 480 


Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly 
                485                 490                 495     


Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro 
            500                 505                 510         


Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro 
        515                 520                 525             


Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser 
    530                 535                 540                 


Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu 
545                 550                 555                 560 


Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser 
                565                 570                 575     


Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln 
            580                 585                 590         


Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg 
        595                 600                 605             


Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly 
    610                 615                 620                 


Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg 
625                 630                 635                 640 


Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe 
                645                 650                 655     


Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln 
            660                 665                 670         


Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg 
        675                 680                 685             


Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn 
    690                 695                 700                 


Thr Gln Gln Val Asn 
705                 


<210>  85
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn 
1               5                   10                  15      


Ser Ser Thr Met Val Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly 
            20                  25                  30          


Phe Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly 
        35                  40                  45              


Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser 
    50                  55                  60                  


Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr 
65                  70                  75                  80  


Pro Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser 
                85                  90                  95      


Lys Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val 
            100                 105                 110         


Asp Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln 
        115                 120                 125             


Pro Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala 
    130                 135                 140                 


Glu Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys 
145                 150                 155                 160 


Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp 
                165                 170                 175     


Ile Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu 
            180                 185                 190         


Ile Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys 
        195                 200                 205             


Lys Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu 
    210                 215                 220                 


Phe Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile 
225                 230                 235                 240 


Lys Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu 
                245                 250                 255     


Val Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala 
            260                 265                 270         


Glu Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met 
        275                 280                 285             


Leu Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val 
    290                 295                 300                 


His Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn 
305                 310                 315                 320 


Gly Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu 
                325                 330                 335     


Ala Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys 
            340                 345                 350         


Met Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys 
        355                 360                 365             


Val Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu 
    370                 375                 380                 


Gln Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys 
385                 390                 395                 400 


Arg Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg 
                405                 410                 415     


Ile Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys 
            420                 425                 430         


Lys Gly Lys Ile Phe 
        435         


<210>  86
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210>  87
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr 
        595                 600                 605             


Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu 
    610                 615                 620                 


Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala 
625                 630                 635                 640 


Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp 
                645                 650                 655     


Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn 
            660                 665                 670         


Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser 
        675                 680                 685             


Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro 
    690                 695                 700                 


Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu 
705                 710                 715                 720 


Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly 
                725                 730                 735     


Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys 
            740                 745                 750         


Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr 
        755                 760                 765             


Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys 
    770                 775                 780                 


Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro 
785                 790                 795                 800 


Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val 
                805                 810                 815     


Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His 
            820                 825                 830         


Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu 
        835                 840                 845             


Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860             


<210>  88
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe 
1               5                   10                  15      


Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala 
            20                  25                  30          


Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg 
        35                  40                  45              


Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser 
    50                  55                  60                  


Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro 
65                  70                  75                  80  


Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val 
                85                  90                  95      


Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser 
            100                 105                 110         


Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln 
        115                 120                 125             


Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala 
    130                 135                 140                 


Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro 
145                 150                 155                 160 


Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn 
                165                 170                 175     


Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu 
            180                 185                 190         


Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile 
        195                 200                 205             


Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu 
    210                 215                 220                 


Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu 
225                 230                 235                 240 


Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser 
                245                 250                 255     


Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala 
            260                 265                 270         


Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala 
        275                 280                 285             


Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser 
    290                 295                 300                 


Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys 
305                 310                 315                 320 


Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr 
                325                 330                 335     


Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala 
            340                 345                 350         


His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro 
        355                 360                 365             


Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser 
    370                 375                 380                 


Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu 
385                 390                 395                 400 


Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val 
                405                 410                 415     


Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro 
            420                 425                 430         


Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser 
        435                 440                 445             


Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser 
    450                 455                 460                 


Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu 
465                 470                 475                 480 


Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met 
                485                 490                 495     


Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg 
            500                 505                 510         


Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu 
        515                 520                 525             


Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn 
    530                 535                 540                 


Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu 
545                 550                 555                 560 


Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr 
                565                 570                 575     


Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His 
            580                 585                 590         


Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg 
        595                 600                 605             


Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val 
    610                 615                 620                 


Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu 
625                 630                 635                 640 


Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro 
                645                 650                 655     


Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg 
            660                 665                 670         


Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser 
        675                 680                 685             


Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu 
    690                 695                 700                 


Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala 
705                 710                 715                 720 


Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr 
                725                 730                 735     


Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr 
            740                 745                 750         


Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val 
        755                 760                 765             


Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr 
    770                 775                 780                 


Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp 
785                 790                 795                 800 


Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly 
                805                 810                 815     


Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp 
            820                 825                 830         


Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val 
        835                 840                 845             


Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile 
    850                 855                 860                 


Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro 
865                 870                 875                 880 


Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys 
                885                 890                 895     


Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr 
            900                 905                 910         


Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe 
        915                 920                 925             


Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr 
    930                 935                 940                 


Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp 
945                 950                 955                 960 


Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn 
                965                 970                 975     


Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Ser Thr Asp Val Asn Ala  Glu Ile His Asp Trp  Val Ile Glu 
        995                 1000                 1005             


Pro Val  Val Gly Asn Arg Leu  Thr His Gln Ile Gln  Glu Leu Thr 
    1010                 1015                 1020             


Leu Asp  Thr Pro Tyr Tyr Phe  Lys Ile Gln Ala Arg  Asn Ser Lys 
    1025                 1030                 1035             


Gly Met  Gly Pro Met Ser Glu  Ala Val Gln Phe Arg  Thr Pro Lys 
    1040                 1045                 1050             


Ala Asp  Ser Ser Asp Lys Met  Pro Asn Asp Gln Ala  Ser Gly Ser 
    1055                 1060                 1065             


Gly Gly  Lys Gly Ser Arg Leu  Pro Asp Leu Gly Ser  Asp Tyr Lys 
    1070                 1075                 1080             


Pro Pro  Met Ser Gly Ser Asn  Ser Pro His Gly Ser  Pro Thr Ser 
    1085                 1090                 1095             


Pro Leu  Asp Ser Asn Met Leu  Leu Val Ile Ile Val  Ser Val Gly 
    1100                 1105                 1110             


Val Ile  Thr Ile Val Val Val  Val Ile Ile Ala Val  Phe Cys Thr 
    1115                 1120                 1125             


Arg Arg  Thr Thr Ser His Gln  Lys Lys Lys Arg Ala  Ala Cys Lys 
    1130                 1135                 1140             


Ser Val  Asn Gly Ser His Lys  Tyr Lys Gly Asn Ser  Lys Asp Val 
    1145                 1150                 1155             


Lys Pro  Pro Asp Leu Trp Ile  His His Glu Arg Leu  Glu Leu Lys 
    1160                 1165                 1170             


Pro Ile  Asp Lys Ser Pro Asp  Pro Asn Pro Ile Met  Thr Asp Thr 
    1175                 1180                 1185             


Pro Ile  Pro Arg Asn Ser Gln  Asp Ile Thr Pro Val  Asp Asn Ser 
    1190                 1195                 1200             


Met Asp  Ser Asn Ile His Gln  Arg Arg Asn Ser Tyr  Arg Gly His 
    1205                 1210                 1215             


Glu Ser  Glu Asp Ser Met Ser  Thr Leu Ala Gly Arg  Arg Gly Met 
    1220                 1225                 1230             


Arg Pro  Lys Met Met Met Pro  Phe Asp Ser Gln Pro  Pro Gln Pro 
    1235                 1240                 1245             


Val Ile  Ser Ala His Pro Ile  His Ser Leu Asp Asn  Pro His His 
    1250                 1255                 1260             


His Phe  His Ser Ser Ser Leu  Ala Ser Pro Ala Arg  Ser His Leu 
    1265                 1270                 1275             


Tyr His  Pro Gly Ser Pro Trp  Pro Ile Gly Thr Ser  Met Ser Leu 
    1280                 1285                 1290             


Ser Asp  Arg Ala Asn Ser Thr  Glu Ser Val Arg Asn  Thr Pro Ser 
    1295                 1300                 1305             


Thr Asp  Thr Met Pro Ala Ser  Ser Ser Gln Thr Cys  Cys Thr Asp 
    1310                 1315                 1320             


His Gln  Asp Pro Glu Gly Ala  Thr Ser Ser Ser Tyr  Leu Ala Ser 
    1325                 1330                 1335             


Ser Gln  Glu Glu Asp Ser Gly  Gln Ser Leu Pro Thr  Ala His Val 
    1340                 1345                 1350             


Arg Pro  Ser His Pro Leu Lys  Ser Phe Ala Val Pro  Ala Ile Pro 
    1355                 1360                 1365             


Pro Pro  Gly Pro Pro Thr Tyr  Asp Pro Ala Leu Pro  Ser Thr Pro 
    1370                 1375                 1380             


Leu Leu  Ser Gln Gln Ala Leu  Asn His His Ile His  Ser Val Lys 
    1385                 1390                 1395             


Thr Ala  Ser Ile Gly Thr Leu  Gly Arg Ser Arg Pro  Pro Met Pro 
    1400                 1405                 1410             


Val Val  Val Pro Ser Ala Pro  Glu Val Gln Glu Thr  Thr Arg Met 
    1415                 1420                 1425             


Leu Glu  Asp Ser Glu Ser Ser  Tyr Glu Pro Asp Glu  Leu Thr Lys 
    1430                 1435                 1440             


Glu Met  Ala His Leu Glu Gly  Leu Met Lys Asp Leu  Asn Ala Ile 
    1445                 1450                 1455             


Thr Thr  Ala 
    1460     


<210>  89
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys 
1               5                   10                  15      


Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His 
            20                  25                  30          


Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Asp 
        35                  40                  45              


Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val 
    50                  55                  60                  


Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys 
65                  70                  75                  80  


Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys 
                85                  90                  95      


Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile 
            100                 105                 110         


Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val 
        115                 120                 125             


Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys 
    130                 135                 140                 


Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His 
145                 150                 155                 160 


Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu 
                165                 170                 175     


Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg 
            180                 185                 190         


Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp 
        195                 200                 205             


Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr 
    210                 215                 220                 


Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly 
225                 230                 235                 240 


Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu 
                245                 250                 255     


Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu 
            260                 265                 270         


Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro 
        275                 280                 285             


Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser 
    290                 295                 300                 


Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val 
305                 310                 315                 320 


Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile 
                325                 330                 335     


Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr 
            340                 345                 350         


Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg 
        355                 360                 365             


Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro 
    370                 375                 380                 


Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys 
385                 390                 395                 400 


His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr 
                405                 410                 415     


Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val 
            420                 425                 430         


Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala Lys Arg Lys 
        435                 440                 445             


Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln 
    450                 455                 460                 


Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys 
465                 470                 475                 480 


Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr 
                485                 490                 495     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val 
            500                 505                 510         


Ser Glu 
        


<210>  90
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  91
<211>  965
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Leu Leu Cys Gly Leu Gly Gln Val Thr Leu Arg Ile Trp Val 
1               5                   10                  15      


Ser Leu Pro Ser Gln Ser Glu Asn Gly Ile Gly Phe Leu Ala Ala Arg 
            20                  25                  30          


Ala Phe Leu Arg Ser Gly Gly Met Glu Ala Leu Thr Thr Gln Leu Gly 
        35                  40                  45              


Pro Gly Arg Glu Gly Ser Ser Ser Pro Asn Ser Lys Gln Glu Leu Gln 
    50                  55                  60                  


Pro Tyr Ser Gly Ser Ser Ala Leu Lys Pro Asn Gln Val Gly Glu Thr 
65                  70                  75                  80  


Ser Leu Tyr Gly Val Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu 
                85                  90                  95      


Arg Leu Cys Leu Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Tyr Ser 
            100                 105                 110         


Tyr Asn Glu Ile His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val 
        115                 120                 125             


Gln Cys Thr Pro Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met 
    130                 135                 140                 


Pro Ile Ser Ser Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu 
145                 150                 155                 160 


Arg Leu Cys Lys Ser Phe Leu Gly Glu His Lys Pro Pro Lys Leu Pro 
                165                 170                 175     


Glu Asn Phe Ala Phe Asp Val Val His Glu Cys Ala Trp Gly Ser Arg 
            180                 185                 190         


Gly Ser Phe Ile Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile 
        195                 200                 205             


Lys Cys Gly Tyr Cys Ser Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe 
    210                 215                 220                 


His Ser His Arg Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala 
225                 230                 235                 240 


Asn Phe Asn Ser Trp Arg Arg His Leu Lys Leu Ser Asp Lys Ser Ala 
                245                 250                 255     


Thr Asp Glu Leu Ser His Ala Trp Glu Asp Val Lys Ala Met Phe Asn 
            260                 265                 270         


Gly Gly Thr Arg Lys Arg Thr Phe Ser Leu Gln Gly Gly Gly Gly Gly 
        275                 280                 285             


Gly Ala Asn Gly Gly Ser Gly Gly Gln Gly Lys Gly Gly Ala Gly Gly 
    290                 295                 300                 


Gly Gly Gly Gly Gly Pro Gly Cys Gly Ala Glu Met Ala Pro Gly Pro 
305                 310                 315                 320 


Pro Pro His Lys Ser Leu Arg Cys Gly Glu Asp Glu Ala Ala Gly Pro 
                325                 330                 335     


Pro Gly Pro Pro Pro Pro His Pro Gln Arg Gly Leu Gly Leu Ala Thr 
            340                 345                 350         


Gly Ala Ser Gly Pro Ala Gly Pro Gly Gly Pro Gly Gly Gly Ala Gly 
        355                 360                 365             


Val Arg Ser Tyr Pro Val Ile Pro Val Pro Ser Lys Gly Phe Gly Leu 
    370                 375                 380                 


Leu Gln Lys Leu Pro Pro Pro Leu Phe Pro His Pro Tyr Gly Phe Pro 
385                 390                 395                 400 


Thr Ala Phe Gly Leu Cys Pro Lys Lys Asp Asp Pro Val Leu Gly Ala 
                405                 410                 415     


Gly Glu Pro Lys Gly Gly Pro Gly Thr Gly Ser Gly Gly Gly Gly Ala 
            420                 425                 430         


Gly Thr Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser His Leu Pro Pro 
        435                 440                 445             


Gly Ala Gly Ala Gly Pro Gly Gly Gly Ala Met Phe Trp Gly His Gln 
    450                 455                 460                 


Pro Ser Gly Ala Ala Lys Asp Ala Ala Ala Val Ala Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Thr Val Tyr Pro Thr Phe Pro Met Phe Trp Pro Ala Ala Gly 
                485                 490                 495     


Ser Leu Pro Val Pro Ser Tyr Pro Ala Ala Gln Ser Gln Ala Lys Ala 
            500                 505                 510         


Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        515                 520                 525             


Gly Ser Gly Ala Pro Glu Pro Leu Asp Gly Ala Glu Pro Ala Lys Glu 
    530                 535                 540                 


Ser Gly Leu Gly Ala Glu Glu Arg Cys Pro Ser Ala Leu Ser Arg Gly 
545                 550                 555                 560 


Pro Leu Asp Glu Asp Gly Thr Asp Glu Ala Leu Pro Pro Pro Leu Ala 
                565                 570                 575     


Pro Leu Pro Pro Pro Pro Pro Pro Pro Ala Arg Lys Gly Ser Tyr Val 
            580                 585                 590         


Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser Ile Ala Lys Leu 
        595                 600                 605             


Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro Ala Arg Gly Pro 
    610                 615                 620                 


Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro Asp Phe Leu Ser 
625                 630                 635                 640 


Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp Val Asp Thr Ala 
                645                 650                 655     


Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe Pro Asp Asp Glu 
            660                 665                 670         


Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser Ala Gly Gly Gly 
        675                 680                 685             


Pro Asp Gly Glu Gln Pro Thr Gly Pro Pro Ser Ala Thr Ser Ser Gly 
    690                 695                 700                 


Ala Asp Gly Pro Ala Asn Ser Pro Asp Gly Gly Ser Pro Arg Pro Arg 
705                 710                 715                 720 


Arg Arg Leu Gly Pro Pro Pro Ala Gly Arg Pro Ala Phe Gly Asp Leu 
                725                 730                 735     


Ala Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser Pro Pro Ser Gly 
            740                 745                 750         


Gly Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro Leu Gly Gly Pro 
        755                 760                 765             


Ala Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu His Val Lys Ser 
    770                 775                 780                 


Ala Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val Cys Thr Pro Glu 
785                 790                 795                 800 


Ala His Glu Pro Asp Lys Glu Asp Asn His Ser Pro Ala Asp Asp Leu 
                805                 810                 815     


Glu Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile Ser Gln Pro Ser 
            820                 825                 830         


Pro Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr Leu Asp Val Thr 
        835                 840                 845             


Gly Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu Ala Arg Glu Glu 
    850                 855                 860                 


Leu Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg Lys Lys Leu Glu 
865                 870                 875                 880 


Arg Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp Gln Met Lys Arg 
                885                 890                 895     


Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu Gln Ile Val Arg 
            900                 905                 910         


Asp Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys Ala Arg Tyr Ala 
        915                 920                 925             


Ile Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu His His Phe Ser 
    930                 935                 940                 


Cys Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn Cys Ser Phe Lys 
945                 950                 955                 960 


Pro Pro Leu Leu Pro 
                965 


<210>  92
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Glu Thr Leu Glu Phe Asn Asp Val Tyr Gln Glu Val Lys Gly 
1               5                   10                  15      


Ser Met Asn Asp Gly Arg Leu Arg Leu Ser Arg Gln Gly Ile Ile Phe 
            20                  25                  30          


Lys Asn Ser Lys Thr Gly Lys Val Asp Asn Ile Gln Ala Gly Glu Leu 
        35                  40                  45              


Thr Glu Gly Ile Trp Arg Arg Val Ala Leu Gly His Gly Leu Lys Leu 
    50                  55                  60                  


Leu Thr Lys Asn Gly His Val Tyr Lys Tyr Asp Gly Phe Arg Glu Ser 
65                  70                  75                  80  


Glu Phe Glu Lys Leu Ser Asp Phe Phe Lys Thr His Tyr Arg Leu Glu 
                85                  90                  95      


Leu Met Glu Lys Asp Leu Cys Val Lys Gly Trp Asn Trp Gly Thr Val 
            100                 105                 110         


Lys Phe Gly Gly Gln Leu Leu Ser Phe Asp Ile Gly Asp Gln Pro Val 
        115                 120                 125             


Phe Glu Ile Pro Leu Ser Asn Val Ser Gln Cys Thr Thr Gly Lys Asn 
    130                 135                 140                 


Glu Val Thr Leu Glu Phe His Gln Asn Asp Asp Ala Glu Val Ser Leu 
145                 150                 155                 160 


Met Glu Val Arg Phe Tyr Val Pro Pro Thr Gln Glu Asp Gly Val Asp 
                165                 170                 175     


Pro Val Glu Ala Phe Ala Gln Asn Val Leu Ser Lys Ala Asp Val Ile 
            180                 185                 190         


Gln Ala Thr Gly Asp Ala Ile Cys Ile Phe Arg Glu Leu Gln Cys Leu 
        195                 200                 205             


Thr Pro Arg Gly Arg Tyr Asp Ile Arg Ile Tyr Pro Thr Phe Leu His 
    210                 215                 220                 


Leu His Gly Lys Thr Phe Asp Tyr Lys Ile Pro Tyr Thr Thr Val Leu 
225                 230                 235                 240 


Arg Leu Phe Leu Leu Pro His Lys Asp Gln Arg Gln Met Phe Phe Val 
                245                 250                 255     


Ile Ser Leu Asp Pro Pro Ile Lys Gln Gly Gln Thr Arg Tyr His Phe 
            260                 265                 270         


Leu Ile Leu Leu Phe Ser Lys Asp Glu Asp Ile Ser Leu Thr Leu Asn 
        275                 280                 285             


Met Asn Glu Glu Glu Val Glu Lys Arg Phe Glu Gly Arg Leu Thr Lys 
    290                 295                 300                 


Asn Met Ser Gly Ser Leu Tyr Glu Met Val Ser Arg Val Met Lys Ala 
305                 310                 315                 320 


Leu Val Asn Arg Lys Ile Thr Val Pro Gly Asn Phe Gln Gly His Ser 
                325                 330                 335     


Gly Ala Gln Cys Ile Thr Cys Ser Tyr Lys Ala Ser Ser Gly Leu Leu 
            340                 345                 350         


Tyr Pro Leu Glu Arg Gly Phe Ile Tyr Val His Lys Pro Pro Val His 
        355                 360                 365             


Ile Arg Phe Asp Glu Ile Ser Phe Val Asn Phe Ala Arg Gly Thr Thr 
    370                 375                 380                 


Thr Thr Arg Ser Phe Asp Phe Glu Ile Glu Thr Lys Gln Gly Thr Gln 
385                 390                 395                 400 


Tyr Thr Phe Ser Ser Ile Glu Arg Glu Glu Tyr Gly Lys Leu Phe Asp 
                405                 410                 415     


Phe Val Asn Ala Lys Lys Leu Asn Ile Lys Asn Arg Gly Leu Lys Glu 
            420                 425                 430         


Gly Met Asn Pro Ser Tyr Asp Glu Tyr Ala Asp Ser Asp Glu Asp Gln 
        435                 440                 445             


His Asp Ala Tyr Leu Glu Arg Met Lys Glu Glu Gly Lys Ile Arg Glu 
    450                 455                 460                 


Glu Asn Ala Asn Asp Ser Ser Asp Asp Ser Gly Glu Glu Thr Asp Glu 
465                 470                 475                 480 


Ser Phe Asn Pro Gly Glu Glu Glu Glu Asp Val Ala Glu Glu Phe Asp 
                485                 490                 495     


Ser Asn Ala Ser Ala Ser Ser Ser Ser Asn Glu Gly Asp Ser Asp Arg 
            500                 505                 510         


Asp Glu Lys Lys Arg Lys Gln Leu Lys Lys Ala Lys Met Ala Lys Asp 
        515                 520                 525             


Arg Lys Ser Arg Lys Lys Pro Val Glu Val Lys Lys Gly Lys Asp Pro 
    530                 535                 540                 


Asn Ala Pro Lys Arg Pro Met Ser Ala Tyr Met Leu Trp Leu Asn Ala 
545                 550                 555                 560 


Ser Arg Glu Lys Ile Lys Ser Asp His Pro Gly Ile Ser Ile Thr Asp 
                565                 570                 575     


Leu Ser Lys Lys Ala Gly Glu Ile Trp Lys Gly Met Ser Lys Glu Lys 
            580                 585                 590         


Lys Glu Glu Trp Asp Arg Lys Ala Glu Asp Ala Arg Arg Asp Tyr Glu 
        595                 600                 605             


Lys Ala Met Lys Glu Tyr Glu Gly Gly Arg Gly Glu Ser Ser Lys Arg 
    610                 615                 620                 


Asp Lys Ser Lys Lys Lys Lys Lys Val Lys Val Lys Met Glu Lys Lys 
625                 630                 635                 640 


Ser Thr Pro Ser Arg Gly Ser Ser Ser Lys Ser Ser Ser Arg Gln Leu 
                645                 650                 655     


Ser Glu Ser Phe Lys Ser Lys Glu Phe Val Ser Ser Asp Glu Ser Ser 
            660                 665                 670         


Ser Gly Glu Asn Lys Ser Lys Lys Lys Arg Arg Arg Ser Glu Asp Ser 
        675                 680                 685             


Glu Glu Glu Glu Leu Ala Ser Thr Pro Pro Ser Ser Glu Asp Ser Ala 
    690                 695                 700                 


Ser Gly Ser Asp Glu 
705                 


<210>  93
<211>  1712
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210>  94
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  95
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  96
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Gly Gly Glu Ala Gly Val Thr Leu Gly Gln Pro His Leu Ser 
1               5                   10                  15      


Arg Gln Asp Leu Thr Thr Leu Asp Val Thr Lys Leu Thr Pro Leu Ser 
            20                  25                  30          


His Glu Val Ile Ser Arg Gln Ala Thr Ile Asn Ile Gly Thr Ile Gly 
        35                  40                  45              


His Val Ala His Gly Lys Ser Thr Val Val Lys Ala Ile Ser Gly Val 
    50                  55                  60                  


His Thr Val Arg Phe Lys Asn Glu Leu Glu Arg Asn Ile Thr Ile Lys 
65                  70                  75                  80  


Leu Gly Tyr Ala Asn Ala Lys Ile Tyr Lys Leu Asp Asp Pro Ser Cys 
                85                  90                  95      


Pro Arg Pro Glu Cys Tyr Arg Ser Cys Gly Ser Ser Thr Pro Asp Glu 
            100                 105                 110         


Phe Pro Thr Asp Ile Pro Gly Thr Lys Gly Asn Phe Lys Leu Val Arg 
        115                 120                 125             


His Val Ser Phe Val Asp Cys Pro Gly His Asp Ile Leu Met Ala Thr 
    130                 135                 140                 


Met Leu Asn Gly Ala Ala Val Met Asp Ala Ala Leu Leu Leu Ile Ala 
145                 150                 155                 160 


Gly Asn Glu Ser Cys Pro Gln Pro Gln Thr Ser Glu His Leu Ala Ala 
                165                 170                 175     


Ile Glu Ile Met Lys Leu Lys His Ile Leu Ile Leu Gln Asn Lys Ile 
            180                 185                 190         


Asp Leu Val Lys Glu Ser Gln Ala Lys Glu Gln Tyr Glu Gln Ile Leu 
        195                 200                 205             


Ala Phe Val Gln Gly Thr Val Ala Glu Gly Ala Pro Ile Ile Pro Ile 
    210                 215                 220                 


Ser Ala Gln Leu Lys Tyr Asn Ile Glu Val Val Cys Glu Tyr Ile Val 
225                 230                 235                 240 


Lys Lys Ile Pro Val Pro Pro Arg Asp Phe Thr Ser Glu Pro Arg Leu 
                245                 250                 255     


Ile Val Ile Arg Ser Phe Asp Val Asn Lys Pro Gly Cys Glu Val Asp 
            260                 265                 270         


Asp Leu Lys Gly Gly Val Ala Gly Gly Ser Ile Leu Lys Gly Val Leu 
        275                 280                 285             


Lys Val Gly Gln Glu Ile Glu Val Arg Pro Gly Ile Val Ser Lys Asp 
    290                 295                 300                 


Ser Glu Gly Lys Leu Met Cys Lys Pro Ile Phe Ser Lys Ile Val Ser 
305                 310                 315                 320 


Leu Phe Ala Glu His Asn Asp Leu Gln Tyr Ala Ala Pro Gly Gly Leu 
                325                 330                 335     


Ile Gly Val Gly Thr Lys Ile Asp Pro Thr Leu Cys Arg Ala Asp Arg 
            340                 345                 350         


Met Val Gly Gln Val Leu Gly Ala Val Gly Ala Leu Pro Glu Ile Phe 
        355                 360                 365             


Thr Glu Leu Glu Ile Ser Tyr Phe Leu Leu Arg Arg Leu Leu Gly Val 
    370                 375                 380                 


Arg Thr Glu Gly Asp Lys Lys Ala Ala Lys Val Gln Lys Leu Ser Lys 
385                 390                 395                 400 


Asn Glu Val Leu Met Val Asn Ile Gly Ser Leu Ser Thr Gly Gly Arg 
                405                 410                 415     


Val Ser Ala Val Lys Ala Asp Leu Gly Lys Ile Val Leu Thr Asn Pro 
            420                 425                 430         


Val Cys Thr Glu Val Gly Glu Lys Ile Ala Leu Ser Arg Arg Val Glu 
        435                 440                 445             


Lys His Trp Arg Leu Ile Gly Trp Gly Gln Ile Arg Arg Gly Val Thr 
    450                 455                 460                 


Ile Lys Pro Thr Val Asp Asp Asp 
465                 470         


<210>  97
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 
65                  70                  75                  80  


Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp 
    130                 135                 140                 


His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 
                165                 170                 175     


Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 
        195                 200                 205             


Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 
            260                 265                 270         


Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 
                405                 410                 415     


Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 
    450                 455                 460                 


Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 
            500                 505                 510         


Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 
                565                 570         


<210>  98
<211>  2115
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Thr Leu His Ala Thr Arg Gly Ala Ala Leu Leu Ser Trp Val Asn 
1               5                   10                  15      


Ser Leu His Val Ala Asp Pro Val Glu Ala Val Leu Gln Leu Gln Asp 
            20                  25                  30          


Cys Ser Ile Phe Ile Lys Ile Ile Asp Arg Ile His Gly Thr Glu Glu 
        35                  40                  45              


Gly Gln Gln Ile Leu Lys Gln Pro Val Ser Glu Arg Leu Asp Phe Val 
    50                  55                  60                  


Cys Ser Phe Leu Gln Lys Asn Arg Lys His Pro Ser Ser Pro Glu Cys 
65                  70                  75                  80  


Leu Val Ser Ala Gln Lys Val Leu Glu Gly Ser Glu Leu Glu Leu Ala 
                85                  90                  95      


Lys Met Thr Met Leu Leu Leu Tyr His Ser Thr Met Ser Ser Lys Ser 
            100                 105                 110         


Pro Arg Asp Trp Glu Gln Phe Glu Tyr Lys Ile Gln Ala Glu Leu Ala 
        115                 120                 125             


Val Ile Leu Lys Phe Val Leu Asp His Glu Asp Gly Leu Asn Leu Asn 
    130                 135                 140                 


Glu Asp Leu Glu Asn Phe Leu Gln Lys Ala Pro Val Pro Ser Thr Cys 
145                 150                 155                 160 


Ser Ser Thr Phe Pro Glu Glu Leu Ser Pro Pro Ser His Gln Ala Lys 
                165                 170                 175     


Arg Glu Ile Arg Phe Leu Glu Leu Gln Lys Val Ala Ser Ser Ser Ser 
            180                 185                 190         


Gly Asn Asn Phe Leu Ser Gly Ser Pro Ala Ser Pro Met Gly Asp Ile 
        195                 200                 205             


Leu Gln Thr Pro Gln Phe Gln Met Arg Arg Leu Lys Lys Gln Leu Ala 
    210                 215                 220                 


Asp Glu Arg Ser Asn Arg Asp Glu Leu Glu Leu Glu Leu Ala Glu Asn 
225                 230                 235                 240 


Arg Lys Leu Leu Thr Glu Lys Asp Ala Gln Ile Ala Met Met Gln Gln 
                245                 250                 255     


Arg Ile Asp Arg Leu Ala Leu Leu Asn Glu Lys Gln Ala Ala Ser Pro 
            260                 265                 270         


Leu Glu Pro Lys Glu Leu Glu Glu Leu Arg Asp Lys Asn Glu Ser Leu 
        275                 280                 285             


Thr Met Arg Leu His Glu Thr Leu Lys Gln Cys Gln Asp Leu Lys Thr 
    290                 295                 300                 


Glu Lys Ser Gln Met Asp Arg Lys Ile Asn Gln Leu Ser Glu Glu Asn 
305                 310                 315                 320 


Gly Asp Leu Ser Phe Lys Leu Arg Glu Phe Ala Ser His Leu Gln Gln 
                325                 330                 335     


Leu Gln Asp Ala Leu Asn Glu Leu Thr Glu Glu His Ser Lys Ala Thr 
            340                 345                 350         


Gln Glu Trp Leu Glu Lys Gln Ala Gln Leu Glu Lys Glu Leu Ser Ala 
        355                 360                 365             


Ala Leu Gln Asp Lys Lys Cys Leu Glu Glu Lys Asn Glu Ile Leu Gln 
    370                 375                 380                 


Gly Lys Leu Ser Gln Leu Glu Glu His Leu Ser Gln Leu Gln Asp Asn 
385                 390                 395                 400 


Pro Pro Gln Glu Lys Gly Glu Val Leu Gly Asp Val Leu Gln Leu Glu 
                405                 410                 415     


Thr Leu Lys Gln Glu Ala Ala Thr Leu Ala Ala Asn Asn Thr Gln Leu 
            420                 425                 430         


Gln Ala Arg Val Glu Met Leu Glu Thr Glu Arg Gly Gln Gln Glu Ala 
        435                 440                 445             


Lys Leu Leu Ala Glu Arg Gly His Phe Glu Glu Glu Lys Gln Gln Leu 
    450                 455                 460                 


Ser Ser Leu Ile Thr Asp Leu Gln Ser Ser Ile Ser Asn Leu Ser Gln 
465                 470                 475                 480 


Ala Lys Glu Glu Leu Glu Gln Ala Ser Gln Ala His Gly Ala Arg Leu 
                485                 490                 495     


Thr Ala Gln Val Ala Ser Leu Thr Ser Glu Leu Thr Thr Leu Asn Ala 
            500                 505                 510         


Thr Ile Gln Gln Gln Asp Gln Glu Leu Ala Gly Leu Lys Gln Gln Ala 
        515                 520                 525             


Lys Glu Lys Gln Ala Gln Leu Ala Gln Thr Leu Gln Gln Gln Glu Gln 
    530                 535                 540                 


Ala Ser Gln Gly Leu Arg His Gln Val Glu Gln Leu Ser Ser Ser Leu 
545                 550                 555                 560 


Lys Gln Lys Glu Gln Gln Leu Lys Glu Val Ala Glu Lys Gln Glu Ala 
                565                 570                 575     


Thr Arg Gln Asp His Ala Gln Gln Leu Ala Thr Ala Ala Glu Glu Arg 
            580                 585                 590         


Glu Ala Ser Leu Arg Glu Arg Asp Ala Ala Leu Lys Gln Leu Glu Ala 
        595                 600                 605             


Leu Glu Lys Glu Lys Ala Ala Lys Leu Glu Ile Leu Gln Gln Gln Leu 
    610                 615                 620                 


Gln Val Ala Asn Glu Ala Arg Asp Ser Ala Gln Thr Ser Val Thr Gln 
625                 630                 635                 640 


Ala Gln Arg Glu Lys Ala Glu Leu Ser Arg Lys Val Glu Glu Leu Gln 
                645                 650                 655     


Ala Cys Val Glu Thr Ala Arg Gln Glu Gln His Glu Ala Gln Ala Gln 
            660                 665                 670         


Val Ala Glu Leu Glu Leu Gln Leu Arg Ser Glu Gln Gln Lys Ala Thr 
        675                 680                 685             


Glu Lys Glu Arg Val Ala Gln Glu Lys Asp Gln Leu Gln Glu Gln Leu 
    690                 695                 700                 


Gln Ala Leu Lys Glu Ser Leu Lys Val Thr Lys Gly Ser Leu Glu Glu 
705                 710                 715                 720 


Glu Lys Arg Arg Ala Ala Asp Ala Leu Glu Glu Gln Gln Arg Cys Ile 
                725                 730                 735     


Ser Glu Leu Lys Ala Glu Thr Arg Ser Leu Val Glu Gln His Lys Arg 
            740                 745                 750         


Glu Arg Lys Glu Leu Glu Glu Glu Arg Ala Gly Arg Lys Gly Leu Glu 
        755                 760                 765             


Ala Arg Leu Gln Gln Leu Gly Glu Ala His Gln Ala Glu Thr Glu Val 
    770                 775                 780                 


Leu Arg Arg Glu Leu Ala Glu Ala Met Ala Ala Gln His Thr Ala Glu 
785                 790                 795                 800 


Ser Glu Cys Glu Gln Leu Val Lys Glu Val Ala Ala Trp Arg Glu Arg 
                805                 810                 815     


Tyr Glu Asp Ser Gln Gln Glu Glu Ala Gln Tyr Gly Ala Met Phe Gln 
            820                 825                 830         


Glu Gln Leu Met Thr Leu Lys Glu Glu Cys Glu Lys Ala Arg Gln Glu 
        835                 840                 845             


Leu Gln Glu Ala Lys Glu Lys Val Ala Gly Ile Glu Ser His Ser Glu 
    850                 855                 860                 


Leu Gln Ile Ser Arg Gln Gln Asn Glu Leu Ala Glu Leu His Ala Asn 
865                 870                 875                 880 


Leu Ala Arg Ala Leu Gln Gln Val Gln Glu Lys Glu Val Arg Ala Gln 
                885                 890                 895     


Lys Leu Ala Asp Asp Leu Ser Thr Leu Gln Glu Lys Met Ala Ala Thr 
            900                 905                 910         


Ser Lys Glu Val Ala Arg Leu Glu Thr Leu Val Arg Lys Ala Gly Glu 
        915                 920                 925             


Gln Gln Glu Thr Ala Ser Arg Glu Leu Val Lys Glu Pro Ala Arg Ala 
    930                 935                 940                 


Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu Gln Gln Gly Arg Gln Phe 
945                 950                 955                 960 


Cys Ser Thr Gln Ala Ala Leu Gln Ala Met Glu Arg Glu Ala Glu Gln 
                965                 970                 975     


Met Gly Asn Glu Leu Glu Arg Leu Arg Ala Ala Leu Met Glu Ser Gln 
            980                 985                 990         


Gly Gln Gln Gln Glu Glu Arg Gly  Gln Gln Glu Arg Glu  Val Ala Arg 
        995                 1000                 1005             


Leu Thr  Gln Glu Arg Gly Arg  Ala Gln Ala Asp Leu  Ala Leu Glu 
    1010                 1015                 1020             


Lys Ala  Ala Arg Ala Glu Leu  Glu Met Arg Leu Gln  Asn Ala Leu 
    1025                 1030                 1035             


Asn Glu  Gln Arg Val Glu Phe  Ala Thr Leu Gln Glu  Ala Leu Ala 
    1040                 1045                 1050             


His Ala  Leu Thr Glu Lys Glu  Gly Lys Asp Gln Glu  Leu Ala Lys 
    1055                 1060                 1065             


Leu Arg  Gly Leu Glu Ala Ala  Gln Ile Lys Glu Leu  Glu Glu Leu 
    1070                 1075                 1080             


Arg Gln  Thr Val Lys Gln Leu  Lys Glu Gln Leu Ala  Lys Lys Glu 
    1085                 1090                 1095             


Lys Glu  His Ala Ser Gly Ser  Gly Ala Gln Ser Glu  Ala Ala Gly 
    1100                 1105                 1110             


Arg Thr  Glu Pro Thr Gly Pro  Lys Leu Glu Ala Leu  Arg Ala Glu 
    1115                 1120                 1125             


Val Ser  Lys Leu Glu Gln Gln  Cys Gln Lys Gln Gln  Glu Gln Ala 
    1130                 1135                 1140             


Asp Ser  Leu Glu Arg Ser Leu  Glu Ala Glu Arg Ala  Ser Arg Ala 
    1145                 1150                 1155             


Glu Arg  Asp Ser Ala Leu Glu  Thr Leu Gln Gly Gln  Leu Glu Glu 
    1160                 1165                 1170             


Lys Ala  Gln Glu Leu Gly His  Ser Gln Ser Ala Leu  Ala Ser Ala 
    1175                 1180                 1185             


Gln Arg  Glu Leu Ala Ala Phe  Arg Thr Lys Val Gln  Asp His Ser 
    1190                 1195                 1200             


Lys Ala  Glu Asp Glu Trp Lys  Ala Gln Val Ala Arg  Gly Arg Gln 
    1205                 1210                 1215             


Glu Ala  Glu Arg Lys Asn Ser  Leu Ile Ser Ser Leu  Glu Glu Glu 
    1220                 1225                 1230             


Val Ser  Ile Leu Asn Arg Gln  Val Leu Glu Lys Glu  Gly Glu Ser 
    1235                 1240                 1245             


Lys Glu  Leu Lys Arg Leu Val  Met Ala Glu Ser Glu  Lys Ser Gln 
    1250                 1255                 1260             


Lys Leu  Glu Glu Arg Leu Arg  Leu Leu Gln Ala Glu  Thr Ala Ser 
    1265                 1270                 1275             


Asn Ser  Ala Arg Ala Ala Glu  Arg Ser Ser Ala Leu  Arg Glu Glu 
    1280                 1285                 1290             


Val Gln  Ser Leu Arg Glu Glu  Ala Glu Lys Gln Arg  Val Ala Ser 
    1295                 1300                 1305             


Glu Asn  Leu Arg Gln Glu Leu  Thr Ser Gln Ala Glu  Arg Ala Glu 
    1310                 1315                 1320             


Glu Leu  Gly Gln Glu Leu Lys  Ala Trp Gln Glu Lys  Phe Phe Gln 
    1325                 1330                 1335             


Lys Glu  Gln Ala Leu Ser Thr  Leu Gln Leu Glu His  Thr Ser Thr 
    1340                 1345                 1350             


Gln Ala  Leu Val Ser Glu Leu  Leu Pro Ala Lys His  Leu Cys Gln 
    1355                 1360                 1365             


Gln Leu  Gln Ala Glu Gln Ala  Ala Ala Glu Lys Arg  His Arg Glu 
    1370                 1375                 1380             


Glu Leu  Glu Gln Ser Lys Gln  Ala Ala Gly Gly Leu  Arg Ala Glu 
    1385                 1390                 1395             


Leu Leu  Arg Ala Gln Arg Glu  Leu Gly Glu Leu Ile  Pro Leu Arg 
    1400                 1405                 1410             


Gln Lys  Val Ala Glu Gln Glu  Arg Thr Ala Gln Gln  Leu Arg Ala 
    1415                 1420                 1425             


Glu Lys  Ala Ser Tyr Ala Glu  Gln Leu Ser Met Leu  Lys Lys Ala 
    1430                 1435                 1440             


His Gly  Leu Leu Ala Glu Glu  Asn Arg Gly Leu Gly  Glu Arg Ala 
    1445                 1450                 1455             


Asn Leu  Gly Arg Gln Phe Leu  Glu Val Glu Leu Asp  Gln Ala Arg 
    1460                 1465                 1470             


Glu Lys  Tyr Val Gln Glu Leu  Ala Ala Val Arg Ala  Asp Ala Glu 
    1475                 1480                 1485             


Thr Arg  Leu Ala Glu Val Gln  Arg Glu Ala Gln Ser  Thr Ala Arg 
    1490                 1495                 1500             


Glu Leu  Glu Val Met Thr Ala  Lys Tyr Glu Gly Ala  Lys Val Lys 
    1505                 1510                 1515             


Val Leu  Glu Glu Arg Gln Arg  Phe Gln Glu Glu Arg  Gln Lys Leu 
    1520                 1525                 1530             


Thr Ala  Gln Val Glu Gln Leu  Glu Val Phe Gln Arg  Glu Gln Thr 
    1535                 1540                 1545             


Lys Gln  Val Glu Glu Leu Ser  Lys Lys Leu Ala Asp  Ser Asp Gln 
    1550                 1555                 1560             


Ala Ser  Lys Val Gln Gln Gln  Lys Leu Lys Ala Val  Gln Ala Gln 
    1565                 1570                 1575             


Gly Gly  Glu Ser Gln Gln Glu  Ala Gln Arg Leu Gln  Ala Gln Leu 
    1580                 1585                 1590             


Asn Glu  Leu Gln Ala Gln Leu  Ser Gln Lys Glu Gln  Ala Ala Glu 
    1595                 1600                 1605             


His Tyr  Lys Leu Gln Met Glu  Lys Ala Lys Thr His  Tyr Asp Ala 
    1610                 1615                 1620             


Lys Lys  Gln Gln Asn Gln Glu  Leu Gln Glu Gln Leu  Arg Ser Leu 
    1625                 1630                 1635             


Glu Gln  Leu Gln Lys Glu Asn  Lys Glu Leu Arg Ala  Glu Ala Glu 
    1640                 1645                 1650             


Arg Leu  Gly His Glu Leu Gln  Gln Ala Gly Leu Lys  Thr Lys Glu 
    1655                 1660                 1665             


Ala Glu  Gln Thr Cys Arg His  Leu Thr Ala Gln Val  Arg Ser Leu 
    1670                 1675                 1680             


Glu Ala  Gln Val Ala His Ala  Asp Gln Gln Leu Arg  Asp Leu Gly 
    1685                 1690                 1695             


Lys Phe  Gln Val Ala Thr Asp  Ala Leu Lys Ser Arg  Glu Pro Gln 
    1700                 1705                 1710             


Ala Lys  Pro Gln Leu Asp Leu  Ser Ile Asp Ser Leu  Asp Leu Ser 
    1715                 1720                 1725             


Cys Glu  Glu Gly Thr Pro Leu  Ser Ile Thr Ser Lys  Leu Pro Arg 
    1730                 1735                 1740             


Thr Gln  Pro Asp Gly Thr Ser  Val Pro Gly Glu Pro  Ala Ser Pro 
    1745                 1750                 1755             


Ile Ser  Gln Arg Leu Pro Pro  Lys Val Glu Ser Leu  Glu Ser Leu 
    1760                 1765                 1770             


Tyr Phe  Thr Pro Ile Pro Ala  Arg Ser Gln Ala Pro  Leu Glu Ser 
    1775                 1780                 1785             


Ser Leu  Asp Ser Leu Gly Asp  Val Phe Leu Asp Ser  Gly Arg Lys 
    1790                 1795                 1800             


Thr Arg  Ser Ala Arg Arg Arg  Thr Thr Gln Ile Ile  Asn Ile Thr 
    1805                 1810                 1815             


Met Thr  Lys Lys Leu Asp Val  Glu Glu Pro Asp Ser  Ala Asn Ser 
    1820                 1825                 1830             


Ser Phe  Tyr Ser Thr Arg Ser  Ala Pro Ala Ser Gln  Ala Ser Leu 
    1835                 1840                 1845             


Arg Ala  Thr Ser Ser Thr Gln  Ser Leu Ala Arg Leu  Gly Ser Pro 
    1850                 1855                 1860             


Asp Tyr  Gly Asn Ser Ala Leu  Leu Ser Leu Pro Gly  Tyr Arg Pro 
    1865                 1870                 1875             


Thr Thr  Arg Ser Ser Ala Arg  Arg Ser Gln Ala Gly  Val Ser Ser 
    1880                 1885                 1890             


Gly Ala  Pro Pro Gly Arg Asn  Ser Phe Tyr Met Gly  Thr Cys Gln 
    1895                 1900                 1905             


Asp Glu  Pro Glu Gln Leu Asp  Asp Trp Asn Arg Ile  Ala Glu Leu 
    1910                 1915                 1920             


Gln Gln  Arg Asn Arg Val Cys  Pro Pro His Leu Lys  Thr Cys Tyr 
    1925                 1930                 1935             


Pro Leu  Glu Ser Arg Pro Ser  Leu Ser Leu Gly Thr  Ile Thr Asp 
    1940                 1945                 1950             


Glu Glu  Met Lys Thr Gly Asp  Pro Gln Glu Thr Leu  Arg Arg Ala 
    1955                 1960                 1965             


Ser Met  Gln Pro Ile Gln Ile  Ala Glu Gly Thr Gly  Ile Thr Thr 
    1970                 1975                 1980             


Arg Gln  Gln Arg Lys Arg Val  Ser Leu Glu Pro His  Gln Gly Pro 
    1985                 1990                 1995             


Gly Thr  Pro Glu Ser Lys Lys  Ala Thr Ser Cys Phe  Pro Arg Pro 
    2000                 2005                 2010             


Met Thr  Pro Arg Asp Arg His  Glu Gly Arg Lys Gln  Ser Thr Thr 
    2015                 2020                 2025             


Glu Ala  Gln Lys Lys Ala Ala  Pro Ala Ser Thr Lys  Gln Ala Asp 
    2030                 2035                 2040             


Arg Arg  Gln Ser Met Ala Phe  Ser Ile Leu Asn Thr  Pro Lys Lys 
    2045                 2050                 2055             


Leu Gly  Asn Ser Leu Leu Arg  Arg Gly Ala Ser Lys  Lys Ala Leu 
    2060                 2065                 2070             


Ser Lys  Ala Ser Pro Asn Thr  Arg Ser Gly Thr Arg  Arg Ser Pro 
    2075                 2080                 2085             


Arg Ile  Ala Thr Thr Thr Ala  Ser Ala Ala Thr Ala  Ala Ala Ile 
    2090                 2095                 2100             


Gly Ala  Thr Pro Arg Ala Lys  Gly Lys Ala Lys His  
    2105                 2110                 2115 


<210>  99
<211>  1357
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile 
1               5                   10                  15      


Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr 
            20                  25                  30          


Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile 
        35                  40                  45              


Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys 
    50                  55                  60                  


Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val 
65                  70                  75                  80  


Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln 
                85                  90                  95      


Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg 
            100                 105                 110         


Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln 
        115                 120                 125             


Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu 
    130                 135                 140                 


Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala 
145                 150                 155                 160 


Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp 
                165                 170                 175     


Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu 
            180                 185                 190         


Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys 
        195                 200                 205             


Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp 
    210                 215                 220                 


Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala 
225                 230                 235                 240 


Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys 
                245                 250                 255     


Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys 
            260                 265                 270         


Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu 
        275                 280                 285             


Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val 
    290                 295                 300                 


Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys 
305                 310                 315                 320 


Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu 
                325                 330                 335     


Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys 
            340                 345                 350         


Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg 
        355                 360                 365             


Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu 
    370                 375                 380                 


Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu 
385                 390                 395                 400 


Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu 
                405                 410                 415     


Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala 
            420                 425                 430         


Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu 
        435                 440                 445             


Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu 
    450                 455                 460                 


Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu 
465                 470                 475                 480 


Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg 
                485                 490                 495     


Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu 
            500                 505                 510         


Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu 
        515                 520                 525             


Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln 
    530                 535                 540                 


Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg 
545                 550                 555                 560 


Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu 
                565                 570                 575     


Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile 
            580                 585                 590         


Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val 
        595                 600                 605             


Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala 
    610                 615                 620                 


Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile 
625                 630                 635                 640 


Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala 
                645                 650                 655     


Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln 
            660                 665                 670         


Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln 
        675                 680                 685             


Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn 
    690                 695                 700                 


Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu 
705                 710                 715                 720 


Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys 
                725                 730                 735     


Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu 
            740                 745                 750         


Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile 
        755                 760                 765             


Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala 
    770                 775                 780                 


Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys 
785                 790                 795                 800 


Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu 
                805                 810                 815     


Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln 
            820                 825                 830         


Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val 
        835                 840                 845             


Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu 
    850                 855                 860                 


Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys 
865                 870                 875                 880 


Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp 
                885                 890                 895     


Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln 
            900                 905                 910         


Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe 
        915                 920                 925             


Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg 
    930                 935                 940                 


Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr 
945                 950                 955                 960 


Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln 
                965                 970                 975     


Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro 
            980                 985                 990         


Pro His Glu Glu Leu Leu Lys Val  Ile Ser Glu Arg Glu  Lys Glu Ile 
        995                 1000                 1005             


Ser Gly  Leu Trp Asn Glu Leu  Asp Ser Leu Lys Asp  Ala Val Glu 
    1010                 1015                 1020             


His Gln  Arg Lys Lys Asn Asn  Asp Leu Arg Glu Lys  Asn Trp Glu 
    1025                 1030                 1035             


Ala Met  Glu Ala Leu Ala Ser  Thr Glu Lys Met Leu  Gln Asp Lys 
    1040                 1045                 1050             


Val Asn  Lys Thr Ser Lys Glu  Arg Gln Gln Gln Val  Glu Ala Val 
    1055                 1060                 1065             


Glu Leu  Glu Ala Lys Glu Val  Leu Lys Lys Leu Phe  Pro Lys Val 
    1070                 1075                 1080             


Ser Val  Pro Ser Asn Leu Ser  Tyr Gly Glu Trp Leu  His Gly Phe 
    1085                 1090                 1095             


Glu Lys  Lys Ala Lys Glu Cys  Met Ala Gly Thr Ser  Gly Ser Glu 
    1100                 1105                 1110             


Glu Val  Lys Val Leu Glu His  Lys Leu Lys Glu Ala  Asp Glu Met 
    1115                 1120                 1125             


His Thr  Leu Leu Gln Leu Glu  Cys Glu Lys Tyr Lys  Ser Val Leu 
    1130                 1135                 1140             


Ala Glu  Thr Glu Gly Ile Leu  Gln Lys Leu Gln Arg  Ser Val Glu 
    1145                 1150                 1155             


Gln Glu  Glu Asn Lys Trp Lys  Val Lys Val Asp Glu  Ser His Lys 
    1160                 1165                 1170             


Thr Ile  Lys Gln Met Gln Ser  Ser Phe Thr Ser Ser  Glu Gln Glu 
    1175                 1180                 1185             


Leu Glu  Arg Leu Arg Ser Glu  Asn Lys Asp Ile Glu  Asn Leu Arg 
    1190                 1195                 1200             


Arg Glu  Arg Glu His Leu Glu  Met Glu Leu Glu Lys  Ala Glu Met 
    1205                 1210                 1215             


Glu Arg  Ser Thr Tyr Val Thr  Glu Val Arg Glu Leu  Lys Asp Leu 
    1220                 1225                 1230             


Leu Thr  Glu Leu Gln Lys Lys  Leu Asp Asp Ser Tyr  Ser Glu Ala 
    1235                 1240                 1245             


Val Arg  Gln Asn Glu Glu Leu  Asn Leu Leu Lys Ala  Gln Leu Asn 
    1250                 1255                 1260             


Glu Thr  Leu Thr Lys Leu Arg  Thr Glu Gln Asn Glu  Arg Gln Lys 
    1265                 1270                 1275             


Val Ala  Gly Asp Leu His Lys  Ala Gln Gln Ser Leu  Glu Leu Ile 
    1280                 1285                 1290             


Gln Ser  Lys Ile Val Lys Ala  Ala Gly Asp Thr Thr  Val Ile Glu 
    1295                 1300                 1305             


Asn Ser  Asp Val Ser Pro Glu  Thr Glu Ser Ser Glu  Lys Glu Thr 
    1310                 1315                 1320             


Met Ser  Val Ser Leu Asn Gln  Thr Val Thr Gln Leu  Gln Gln Leu 
    1325                 1330                 1335             


Leu Gln  Ala Val Asn Gln Gln  Leu Thr Lys Glu Lys  Glu His Tyr 
    1340                 1345                 1350             


Gln Val  Leu Glu 
    1355         


<210>  100
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 
    130                 135                 140                 


His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe 
145                 150                 155                 160 


Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 
                165                 170                 175     


Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 
            180                 185                 190         


Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met 
        195                 200                 205             


Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu 
    210                 215                 220                 


Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met 
225                 230                 235                 240 


Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 
                245                 250                 255     


Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 
            260                 265                 270         


Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 
        275                 280                 285             


Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 
    290                 295                 300                 


Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg 
305                 310                 315                 320 


Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser 
                325                 330                 335     


Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg 
            340                 345                 350         


His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu 
        355                 360                 365             


Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln 
    370                 375                 380                 


Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
385                 390             


<210>  101
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  102
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  103
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  104
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val 
                85                  90                  95      


Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile 
            100                 105                 110         


Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg 
        115                 120                 125             


Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn 
    130                 135                 140                 


Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln 
145                 150                 155                 160 


Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys 
                165                 170                 175     


Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp 
            180                 185                 190         


Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His 
        195                 200                 205             


Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp 
    210                 215                 220                 


Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu 
225                 230                 235                 240 


Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp 
                245                 250                 255     


Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala 
            260                 265                 270         


Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys 
        275                 280                 285             


Ser Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295             


<210>  105
<211>  2541
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  106
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg 
1               5                   10                  15      


Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser 
            20                  25                  30          


Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser 
        35                  40                  45              


Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly 
    50                  55                  60                  


Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro 
65                  70                  75                  80  


Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala 
                85                  90                  95      


Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu 
            100                 105                 110         


Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe 
        115                 120                 125             


Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys 
    130                 135                 140                 


Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg 
145                 150                 155                 160 


Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val 
                165                 170                 175     


Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala 
            180                 185                 190         


Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu 
        195                 200                 205             


Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp 
    210                 215                 220                 


Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys 
225                 230                 235                 240 


Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu 
                245                 250                 255     


Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala 
            260                 265                 270         


Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn 
        275                 280                 285             


Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr 
    290                 295                 300                 


Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu 
305                 310                 315                 320 


Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp 
                325                 330                 335     


Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu 
            340                 345                 350         


Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala 
        355                 360                 365             


Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His 
    370                 375                 380                 


Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val 
385                 390                 395                 400 


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile 
                405                 410                 415     


Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser 
            420                 425                 430         


Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile 
        435                 440                 445             


Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln 
    450                 455                 460                 


Gln Gln His Glu Val Leu 
465                 470 


<210>  107
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  108
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  109
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  109
uguaaacauc cuacacucuc agc                                               23


<210>  110
<211>  104
<212>  DNA
<213>  Homo sapiens

<400>  110
attcttctat agttcatgag catgatgatt gggtgttcat gacatgtgtg agatgtgcca       60

ccctctgaac cttgttccca catcggcaca ttatccatct aacc                       104


<210>  111
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  111
agcccccugg ccccaaaccc                                                   20


<210>  112
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  112
uuguacaugg uaggcuuuca uu                                                22


<210>  113
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  113
ucgaggagcu cacagucuag u                                                 21


<210>  114
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  114
uguaaacauc cccgacugga ag                                                22


<210>  115
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  115
gaaguuguuc gugguggauu cg                                                22


<210>  116
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  116
cuuucagucg gauguuugca gc                                                22


<210>  117
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  117
ugagguagua guuuguacag uu                                                22


<210>  118
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  118
auauaauaca accugcuaag ug                                                22


<210>  119
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  119
uagcuuauca gacugauguu ga                                                22


<210>  120
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  120
ugagguagua gauuguauag uu                                                22


<210>  121
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  121
gcuggucugc guggugcucg g                                                 21


<210>  122
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  122
uauguaacac gguccacuaa cc                                                22


