               SEQUENCE LISTING

<110> Scuola Internazionale Superiore di Studi Avanzati - SISSA; Fondazione Istituto Italiano di Tecnologia; Forschungszentrum Juelich GMBH

<120> SERPIN inhibitors for the treatment of prion and prion-like diseases

<130> PC1669RRI 

<160> 3

<170> BiSSAP 1.3.6

<210> 1
<211> 376
<212> PRT
<213> Homo sapiens


<220> 
<223> human plasminogen activator inhibitor PAI-1

<400> 1
Ala Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly Val Arg Val 
1               5                   10                  15      
Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val Val Phe Ser 
            20                  25                  30          
Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu Thr Thr Gly 
        35                  40                  45              
Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe Lys Ile Asp 
    50                  55                  60                  
Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys Glu Leu Met 
65                  70                  75                  80  
Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala Ile Phe Val 
                85                  90                  95      
Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His Phe Phe Arg 
            100                 105                 110         
Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu Val Glu Arg 
        115                 120                 125             
Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr Lys Gly Met 
    130                 135                 140                 
Ile Ser His Leu Leu Gly Thr Gly Ala Val Asp Gln Leu Thr Arg Leu 
145                 150                 155                 160 
Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe 
                165                 170                 175     
Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser Asp Gly Ser 
            180                 185                 190         
Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr 
        195                 200                 205             
Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro 
    210                 215                 220                 
Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys 
225                 230                 235                 240 
Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile 
                245                 250                 255     
Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Arg Leu Leu Val Leu 
            260                 265                 270         
Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys Pro Leu Glu 
        275                 280                 285             
Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala Asp Phe Thr 
    290                 295                 300                 
Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Leu Ala Leu Gln Lys 
305                 310                 315                 320 
Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser Ser Ser Thr 
                325                 330                 335     
Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile Ile Ile Asp 
            340                 345                 350         
Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly Thr Val Leu 
        355                 360                 365             
Phe Met Gly Gln Val Met Glu Pro 
    370                 375     

<210> 2
<211> 394
<212> PRT
<213> Homo sapiens


<220> 
<223> human alpha-1-antitrypsin SERPINA1

<400> 2
Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      
Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          
Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              
Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  
Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  
Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      
Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         
Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             
Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 
Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 
Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     
Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         
Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             
His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 
Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 
Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     
Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         
Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             
Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 
Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 
Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     
Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         
Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             
Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 
Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 

<210> 3
<211> 401
<212> PRT
<213> Homo sapiens


<220> 
<223> human antichymotrypsin SERPINA3

<400> 3
Met Ala Ser Asn Ser Pro Leu Asp Glu Glu Asn Leu Thr Gln Glu Asn 
1               5                   10                  15      
Gln Asp Arg Gly Thr His Val Asp Leu Gly Leu Ala Ser Ala Asn Val 
            20                  25                  30          
Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Val Leu Lys Ala Pro Asp 
        35                  40                  45              
Lys Asn Val Ile Phe Ser Pro Pro Ser Ile Ser Thr Ala Leu Ala Phe 
    50                  55                  60                  
Leu Ser Leu Gly Ala His Asn Thr Thr Leu Thr Glu Ile Leu Lys Gly 
65                  70                  75                  80  
Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu Ala Glu Ile His Gln Ser 
                85                  90                  95      
Phe Gln His Leu Leu Arg Thr Leu Asn Gln Ser Ser Asp Glu Leu Gln 
            100                 105                 110         
Leu Ser Met Gly Asn Ala Met Phe Val Lys Glu Gln Leu Ser Leu Leu 
        115                 120                 125             
Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu Tyr Gly Ser Glu Ala Phe 
    130                 135                 140                 
Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala Lys Lys Leu Ile Asn Asp 
145                 150                 155                 160 
Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile Thr Asp Leu Ile Lys Asp 
                165                 170                 175     
Leu Asp Ser Gln Thr Met Met Val Leu Val Asn Tyr Ile Phe Phe Lys 
            180                 185                 190         
Ala Lys Trp Glu Met Pro Phe Asp Pro Gln Asp Thr His Gln Ser Arg 
        195                 200                 205             
Phe Tyr Leu Ser Lys Lys Lys Trp Val Met Val Pro Met Met Ser Leu 
    210                 215                 220                 
His His Leu Thr Ile Pro Tyr Phe Arg Asp Glu Glu Leu Ser Cys Thr 
225                 230                 235                 240 
Val Val Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala Leu Phe Ile Leu 
                245                 250                 255     
Pro Asp Gln Asp Lys Met Glu Glu Val Glu Ala Met Leu Leu Pro Glu 
            260                 265                 270         
Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu Phe Arg Glu Ile Gly Glu 
        275                 280                 285             
Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg Asp Tyr Asn Leu Asn Asp 
    290                 295                 300                 
Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala Phe Thr Ser Lys Ala Asp 
305                 310                 315                 320 
Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu Ala Val Ser Gln Val Val 
                325                 330                 335     
His Lys Ala Val Leu Asp Val Phe Glu Glu Gly Thr Glu Ala Ser Ala 
            340                 345                 350         
Ala Thr Ala Val Lys Ile Thr Leu Leu Ser Ala Leu Val Glu Thr Arg 
        355                 360                 365             
Thr Ile Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr 
    370                 375                 380                 
Asp Thr Gln Asn Ile Phe Phe Met Ser Lys Val Thr Asn Pro Lys Gln 
385                 390                 395                 400 
Ala 
    

