                         SEQUENCE LISTING

<110>  ALGAE-C INC.
 
<120>  ENGINEERED MICROORGANISM FOR THE PRODUCTION OF CANNABINOID 
       BIOSYNTHETIC PATHWAY PRODUCTS

<130>  85068430

<150>  62/664322
<151>  2018-04-30

<150>  62/813927
<151>  2019-03-05

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized TKS

<400>  1
atgaaccacc tgcgcgctga gggccccgcc tccgtcctcg ccattgggac ggcgaaccct       60

gagaacattc tcctgcagga tgagtttccg gattactact ttcgggtcac gaagtcggag      120

cacatgaccc agctcaagga gaagtttcgg aagatttgcg ataagagcat gatccgcaag      180

cgcaactgct ttctgaacga ggagcacctg aagcagaacc cccggctcgt cgagcacgag      240

atgcagacgc tcgatgcccg gcaggacatg ctcgtggtcg aggtccctaa gctcggcaag      300

gacgcttgcg cgaaggctat caaggagtgg ggtcagccca agtccaagat cacccatctg      360

atttttacct ccgcgtcgac cacggatatg cctggggctg actaccactg cgcgaagctg      420

ctgggtctct ccccgtcggt gaagcgggtc atgatgtacc agctgggctg ctacgggggg      480

ggtacggtcc tgcgcatcgc gaaggacatc gctgagaaca acaagggtgc ccgggtcctc      540

gcggtgtgct gcgacattat ggcttgcctg tttcggggtc cctcggagtc ggacctggag      600

ctgctggtcg gtcaggctat ctttggggat ggcgctgccg ccgtgattgt cggcgccgag      660

ccggatgagt cggtgggtga gcggccgatc ttcgagctcg tctccaccgg gcagacgatc      720

ctccctaact ccgagggcac catcgggggg cacattcgcg aggcggggct catttttgat      780

ctgcacaagg acgtgccgat gctgatttcc aacaacatcg agaagtgcct catcgaggct      840

ttcaccccca ttggtatttc cgattggaac agcatttttt ggatcaccca cccgggcggt      900

aaggctattc tggataaggt ggaggagaag ctccatctca agtccgacaa gtttgtcgat      960

agccgccatg tcctgagcga gcatgggaac atgtccagct ccacggtgct ctttgtcatg     1020

gacgagctgc ggaagcgctc gctggaggag ggcaagtcca ccaccggcga cggtttcgag     1080

tggggggtcc tgttcggttt tggtcccggt ctcacggtgg agcgggtggt cgtgcgctcg     1140

gtgcccatca agtac                                                      1155


<210>  2
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized OAC

<400>  2
atggcggtga agcacctgat tgtcctcaag ttcaaggacg agatcaccga ggcccagaag       60

gaggagtttt tcaagaccta cgtgaacctc gtgaacatta tccctgcgat gaaggacgtg      120

tactggggga aggatgtcac gcagaagaac aaggaggagg gttacacgca catcgtcgag      180

gtcacgttcg agtcggtcga gaccattcag gattacatca tccatcccgc tcatgtgggt      240

tttggggacg tgtaccgcag cttctgggag aagctgctga ttttcgatta cacccctcgc      300

aag                                                                    303


<210>  3
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized OAC2

<400>  3
atgaagatga aggctgcgtg gagcgcgacg atttactccc tgctgagctg gtgcgtcgtc       60

aagaacgaga agttctttcc tgagcgcacg attgacattt ccaagagcaa catggggcgc      120

atgaacaacg tcgtcctgaa ctccctccac acgctcaagt gctacctgaa ctacgtctcg      180

gtgccgtttt ttctgattct gctctcccac atttttacgc cggtgtacat ttttcatggc      240

tgggacgata ttcataagat tcacattcgc ctggagaagt tctttctcct gggtttttgc      300

gatttcatct tcgagctgca gtacaaccag atgctgcatt gccatagcct ctcgcagctg      360

tcgtccagca gcagcttt                                                    378


<210>  4
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized aromatic prenyltransferase

<400>  4
atggggctca gctcggtgtg caccttctcg ttccagacga actaccacac gctgctgaac       60

ccccacaaca acaaccctaa gacctccctg ctctgctacc gccacccgaa gacccccatt      120

aagtacagct acaacaactt cccgtccaag cactgctcca cgaagtcgtt ccacctgcag      180

aacaagtgct cggagagcct cagcatcgcg aagaacagca tccgggctgc gaccacgaac      240

cagacggagc cgcccgagtc ggataaccac tcggtcgcta cgaagattct gaacttcggt      300

aaggcgtgct ggaagctcca gcgcccctac accatcattg cgtttacgag ctgcgcttgc      360

ggtctcttcg ggaaggagct cctgcacaac acgaacctga tcagctggtc cctcatgttt      420

aaggcttttt tcttcctcgt ggccatcctg tgcattgcgt ccttcacgac caccatcaac      480

cagatttacg acctgcacat tgaccgcatt aacaagcctg acctgcctct ggcctcgggg      540

gagatttcgg tgaacacggc ttggatcatg tcgatcatcg tggctctctt tggtctcatt      600

atcacgatta agatgaaggg cggccccctg tacatttttg gttactgctt tgggatcttc      660

ggtgggatcg tctacagcgt gcccccgttt cggtggaagc agaacccgtc gacggccttt      720

ctcctgaact ttctggctca tattattacg aacttcacct tctactacgc gagccgcgct      780

gcgctcgggc tgccgttcga gctccgcccg agcttcacgt ttctcctggc ctttatgaag      840

agcatgggtt cggctctcgc cctcattaag gacgcttccg acgtggaggg ggataccaag      900

ttcggcatca gcacgctcgc gtccaagtac ggctcccgga acctcaccct gttttgctcg      960

gggattgtcc tcctgagcta cgtggccgcc atcctggctg gcatcatctg gccgcaggct     1020

ttcaactcca acgtcatgct cctctcgcac gcgattctgg ccttctggct gattctgcag     1080

acccgcgact tcgccctcac gaactacgac cctgaggctg gtcggcgctt ttacgagttt     1140

atgtggaagc tgtactacgc ggagtacctg gtctacgtgt ttatc                     1185


<210>  5
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized hexanoyl-CoA synthetase1

<400>  5
atgggcaaga actacaagtc gctggattcc gtggtggctt cggacttcat cgctctgggg       60

atcaccagcg aggtcgccga gaccctccac gggcgcctcg ctgagatcgt gtgcaactac      120

ggtgccgcca cgccgcagac ctggattaac atcgccaacc atatcctgtc gccggatctc      180

cctttcagcc tgcatcagat gctgttttac gggtgctaca aggacttcgg gccggcgcct      240

cctgcttgga tccccgatcc cgagaaggtc aagagcacga acctgggcgc tctcctcgag      300

aagcgcggga aggagtttct cggggtgaag tacaaggatc ccatcagctc gtttagccat      360

tttcaggagt tctccgtccg gaaccctgag gtgtactggc ggacggtcct catggatgag      420

atgaagattt cgtttagcaa ggatccggag tgcattctcc ggcgggatga tatcaacaac      480

cctgggggca gcgagtggct ccccggtggt tacctgaact ccgccaagaa ctgcctcaac      540

gtcaactcca acaagaagct gaacgatacg atgattgtct ggcgggacga ggggaacgac      600

gatctgcccc tcaacaagct gaccctcgat cagctgcgga agcgggtctg gctggtcggg      660

tacgctctgg aggagatggg tctcgagaag ggctgcgcca tcgcgattga catgccgatg      720

cacgtggatg ccgtggtcat ttacctcgct attgtcctgg cgggttacgt cgtggtgtcg      780

attgctgaca gcttctccgc tcctgagatc tcgacgcggc tccggctctc gaaggccaag      840

gccattttta cgcaggacca cattattcgg gggaagaagc ggattcccct ctactcgcgg      900

gtggtcgagg cgaagtcgcc catggccatt gtcattcctt gctcggggag caacatcggc      960

gccgagctcc gcgacgggga tatcagctgg gattactttc tggagcgcgc caaggagttc     1020

aagaactgcg agtttaccgc tcgggagcag cccgtggatg cttacacgaa cattctgttc     1080

agctcgggca cgacgggtga gccgaaggcg attccttgga cgcaggctac ccctctgaag     1140

gctgctgcgg atgggtggtc ccacctcgat atccgcaagg gggacgtgat tgtctggccc     1200

accaacctgg gttggatgat ggggccttgg ctggtgtacg cctccctgct gaacggggct     1260

agcattgctc tctacaacgg gagccctctc gtctccggct ttgctaagtt tgtgcaggac     1320

gccaaggtga cgatgctcgg ggtcgtgcct agcattgtgc ggagctggaa gtcgaccaac     1380

tgcgtctcgg gctacgattg gtccaccatt cgctgctttt cctcgtccgg tgaggccagc     1440

aacgtggatg agtacctgtg gctgatgggt cgggctaact acaagccggt catcgagatg     1500

tgcggcggca cggagattgg gggggccttt tcggctgggt cgtttctgca ggctcagtcc     1560

ctgtcgtcgt tttcgtcgca gtgcatgggc tgcaccctct acatcctgga taagaacggt     1620

taccctatgc ccaagaacaa gcccggcatc ggggagctgg cgctgggccc ggtcatgttt     1680

ggtgcttcga agacgctgct gaacggtaac catcacgacg tgtacttcaa gggtatgcct     1740

acgctgaacg gtgaggtcct gcgccgccac ggtgacattt ttgagctcac gagcaacggt     1800

tactaccatg cgcatggtcg cgctgacgat accatgaaca ttggcggtat caagatctcg     1860

agcattgaga tcgagcgcgt ctgcaacgag gtcgacgatc gcgtgtttga gaccacggct     1920

atcggtgtcc cgcctctcgg cggcggtccg gagcagctcg tcatcttttt cgtcctgaag     1980

gattcgaacg ataccacgat cgatctgaac cagctgcgcc tgtcctttaa cctgggcctc     2040

cagaagaagc tgaaccctct cttcaaggtg acccgcgtgg tccccctctc ctccctgcct     2100

cggacggcta cgaacaagat catgcgccgg gtcctgcggc agcagttctc ccacttcgag     2160


<210>  6
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized tetrahydrocannabinolic acid synthase

<400>  6
atgaactgct cggcgttttc cttttggttt gtctgcaaga ttattttttt ttttctcagc       60

ttccacatcc agatttccat tgctaaccct cgggagaact ttctgaagtg cttttcgaag      120

cacatcccta acaacgtggc gaaccctaag ctggtctaca cgcagcatga tcagctgtac      180

atgtcgatcc tgaactccac gatccagaac ctccggttta tctcggatac gacccctaag      240

cccctggtga ttgtgacgcc gtccaacaac agccatattc aggctacgat tctctgctcg      300

aagaaggtgg ggctccagat ccggacccgg tccgggggcc atgatgctga ggggatgagc      360

tacatctccc aggtcccctt cgtcgtggtg gatctgcgga acatgcattc gatcaagatt      420

gatgtccact cgcagaccgc gtgggtcgag gccggcgcta ccctcggtga ggtctactac      480

tggatcaacg agaagaacga gaacctcagc ttccccggcg gctactgccc gacggtcggg      540

gtcggtgggc acttttcggg tgggggctac ggcgccctca tgcggaacta cggcctcgct      600

gcggacaaca ttatcgatgc tcatctcgtc aacgtggatg gcaaggtgct cgatcgcaag      660

tcgatgggcg aggatctctt ttgggcgatt cggggcgggg gcggcgagaa ctttggcatc      720

attgctgctt ggaagattaa gctcgtggcc gtccctagca agtcgaccat tttctcggtg      780

aagaagaaca tggagattca cggtctcgtc aagctcttta acaagtggca gaacattgcc      840

tacaagtacg acaaggacct ggtgctgatg acccatttta ttaccaagaa cattacggac      900

aaccacggga agaacaagac cacggtccat ggctactttt cgagcatttt ccatgggggg      960

gtcgatagcc tcgtcgacct gatgaacaag tccttccccg agctgggcat caagaagacc     1020

gactgcaagg agtttagctg gatcgatacc acgatttttt actcgggggt cgtgaacttt     1080

aacaccgcca acttcaagaa ggagatcctg ctcgatcgct ccgctggcaa gaagacggct     1140

ttcagcatta agctcgatta cgtgaagaag cccatccctg agacggctat ggtgaagatt     1200

ctggagaagc tctacgagga ggacgtcggg gctggcatgt acgtgctcta cccgtacggt     1260

ggtatcatgg aggagatctc ggagtcggcc atccctttcc cccatcgggc gggcatcatg     1320

tacgagctgt ggtacaccgc cagctgggag aagcaggagg ataacgagaa gcatattaac     1380

tgggtccggt cggtctacaa cttcacgacg ccctacgtga gccagaaccc ccgcctcgct     1440

tacctcaact accgggacct cgatctgggc aagacgaacc atgcctcgcc caacaactac     1500

acccaggcgc ggatttgggg tgagaagtac tttgggaaga actttaaccg cctcgtcaag     1560

gtgaagacga aggtggatcc caacaacttc ttccgcaacg agcagtccat cccccccctc     1620

ccgcctcacc accat                                                      1635


<210>  7
<211>  1632
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized cannabidiolic acid synthetase

<400>  7
atgaagtgct ccaccttttc cttctggttc gtctgcaaga tcattttttt tttcttctcc       60

tttaacatcc agacgtcgat cgctaaccct cgcgagaact ttctgaagtg cttttcccag      120

tacattccga acaacgctac caacctcaag ctcgtgtaca cgcagaacaa ccctctctac      180

atgtccgtgc tcaactccac gattcataac ctgcggttta cgagcgacac cacccctaag      240

cctctcgtca ttgtgacccc ttcgcacgtc tcccatatcc agggcacgat cctgtgctcc      300

aagaaggtcg gcctgcagat ccggacgcgc tccggtgggc atgattccga gggtatgtcg      360

tacatcagcc aggtgccgtt tgtcatcgtg gatctccgca acatgcgcag cattaagatt      420

gatgtccatt cgcagaccgc ttgggtcgag gcgggggcga cgctcggtga ggtgtactac      480

tgggtcaacg agaagaacga gaacctctcc ctcgctgccg gctactgccc caccgtctgc      540

gcgggggggc attttggggg cggcggttac gggccgctca tgcggaacta cggcctggcg      600

gcggacaaca tcatcgacgc tcacctcgtc aacgtccatg gtaaggtgct cgatcggaag      660

tccatggggg aggacctgtt ttgggcgctc cgggggggcg gcgctgagag ctttggtatc      720

attgtcgcct ggaagatccg cctcgtggct gtcccgaagt cgaccatgtt cagcgtcaag      780

aagattatgg agattcacga gctggtcaag ctcgtgaaca agtggcagaa cattgcctac      840

aagtacgaca aggacctgct cctgatgacc catttcatta cgcggaacat cacggacaac      900

caggggaaga acaagaccgc gattcatacg tacttcagct ccgtcttcct cggcggcgtg      960

gatagcctgg tggacctcat gaacaagagc tttccggagc tgggcatcaa gaagacggat     1020

tgccgccagc tcagctggat tgacacgatc atcttttact cgggggtggt caactacgac     1080

acggacaact ttaacaagga gattctgctc gatcggtccg ccggtcagaa cggtgccttt     1140

aagatcaagc tcgattacgt caagaagccc attcccgaga gcgtgtttgt ccagattctc     1200

gagaagctct acgaggagga cattggtgcc ggtatgtacg cgctctaccc gtacgggggc     1260

attatggacg agattagcga gagcgccatt cctttccctc atcgcgctgg cattctctac     1320

gagctgtggt acatttgcag ctgggagaag caggaggaca acgagaagca cctcaactgg     1380

attcgcaaca tctacaactt catgaccccg tacgtctcga agaaccctcg gctggcttac     1440

ctgaactacc gcgatctcga cattggcatt aacgatccga agaaccccaa caactacacg     1500

caggcgcgga tctggggtga gaagtacttt ggtaagaact ttgatcggct cgtgaaggtc     1560

aagacgctcg tggaccctaa caacttcttt cgcaacgagc agtcgatccc cccgctgcct     1620

cgccaccggc ac                                                         1632


<210>  8
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized TKS

<400>  8
atgaatcatc ttcgcgctga agggccggct tccgttctcg cgattgggac ggctaaccct       60

gagaacatct tgttgcaaga cgagttccca gactactatt ttcgtgttac gaaatctgag      120

cacatgacac aacttaaaga aaagttccgt aaaatctgcg acaaaagtat gattaggaag      180

agaaattgct ttctcaacga agagcacctc aagcagaacc cgaggttggt tgagcacgaa      240

atgcaaacac tcgacgcgcg tcaagatatg cttgtagttg aagtaccaaa attgggtaaa      300

gacgcttgtg ctaaagcgat caaagagtgg ggacaaccta agagcaaaat tactcacttg      360

atctttactt ctgcatcgac tactgacatg cccggggcag attatcattg tgcgaagctt      420

ttgggacttt cacccagtgt caaacgcgta atgatgtatc agttgggttg ctacggcggt      480

ggtacagtgc tcagaatcgc aaaagacatt gcggaaaaca acaaaggggc aagagtcctc      540

gcggtttgct gtgatatcat ggcgtgcttg tttcgaggac cgagtgaatc tgacctcgag      600

ttgcttgttg gacaagcaat ttttggagat ggggccgcag ccgtcatcgt gggagcagag      660

cctgacgagt ctgtggggga acgtcccatc tttgaactcg ttagtaccgg acagacaatt      720

ttgcccaatt ccgaaggaac tattggtggt cacatccgag aagctgggtt gatcttcgat      780

cttcataaag atgtcccgat gctcattagt aataatatcg aaaaatgtct cattgaagcg      840

tttacaccca tcggtattag cgattggaat agtattttct ggatcaccca ccccggcggc      900

aaggcgattc ttgataaggt ggaggagaaa ttgcacttga agagtgacaa atttgtagac      960

agccgccacg ttctttccga gcatggcaat atgtcatctt ctacggtact ctttgtaatg     1020

gacgaactcc gcaagcgctc tctcgaggag ggtaagtcaa caacgggtga cggctttgag     1080

tggggggttt tgtttgggtt tggccccggc ttgaccgtag aacgtgtggt cgtgcgttcc     1140

gtgccgatta agtat                                                      1155


<210>  9
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized OAC

<400>  9
atggcagtta aacacctcat cgtcctcaaa ttcaaagatg agatcactga ggctcaaaag       60

gaggagttct tcaaaacgta tgtaaatctt gtgaatatta tccctgcgat gaaggatgta      120

tattggggga aggacgtgac gcaaaaaaac aaagaggaag gctacacgca tattgtcgaa      180

gttactttcg agtcggttga aaccatccag gattacatta tccaccccgc acatgtaggc      240

tttggtgatg tgtaccgatc attctgggag aaattgttga tcttcgatta tacgccaagg      300

aag                                                                    303


<210>  10
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized OAC2

<400>  10
atgaaaatga aggcagcttg gtcggcgaca atctattcac tcctctcctg gtgcgtagta       60

aaaaacgaaa aattttttcc agagcgtacc attgacatta gcaaatccaa tatgggtcga      120

atgaataacg ttgtgctcaa tagtctccac acacttaagt gttatttgaa ctacgtcagc      180

gtccccttct ttctcatcct tctttcgcac atctttacgc ctgtatacat tttccacggg      240

tgggacgaca tccataaaat tcacatccga ctcgagaagt tcttcttgtt gggcttctgc      300

gattttattt tcgagctcca atacaatcag atgcttcact gccatagcct ttctcagttg      360

tcgtccagtt catcattc                                                    378


<210>  11
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized aromatic prenyltransferase

<400>  11
atgggcctca gcagtgtatg taccttttca ttccagacta actatcacac gttgcttaat       60

ccgcataaca ataacccgaa aacttcgttg ctttgttata ggcacccgaa gacccctatc      120

aaatatagtt ataataactt tccaagcaaa cactgttcga ctaagtcctt tcatttgcaa      180

aataaatgtt ccgagtctct tagcattgcg aagaactcca ttcgtgctgc tactacaaat      240

caaactgagc cccccgagag tgataatcac agtgtagcaa cgaagatctt gaactttggg      300

aaggcatgct ggaaattgca acgtccttac accatcatcg cgttcacgtc ttgcgcatgc      360

ggcttgttcg gaaaggagct tttgcataat acgaatctta tcagttggtc gttgatgttc      420

aaggccttct ttttcctcgt tgcaattctt tgtattgcca gcttcacaac gacaattaac      480

cagatttatg atcttcatat cgatagaatc aataaacccg acttgccttt ggcatcagga      540

gaaatctctg tcaatacagc atggattatg tccattattg tcgcattgtt tggacttatc      600

atcaccatca agatgaaggg agggccactc tatatcttcg gttattgttt tggaatcttt      660

ggcggtatcg tatattctgt acctccgttc agatggaaac agaaccccag cacggcgttt      720

cttttgaact ttcttgctca catcatcact aattttacat tttactatgc aagtagggca      780

gccctcggac tccccttcga gttgaggccg agttttactt ttctccttgc gtttatgaaa      840

agtatgggga gtgctcttgc ccttatcaag gatgcaagtg atgttgaagg cgatactaaa      900

tttggtatca gtaccctcgc cagtaaatat gggtccagga atctcacact cttttgttca      960

gggatcgttc ttctttcata cgtggctgca atccttgctg gtattatctg gccccaagct     1020

ttcaatagta atgtcatgct ccttagccat gccatccttg cattttggct catcttgcaa     1080

acgagggatt ttgctctcac caactatgat cccgaagctg gaaggcgttt ctatgagttt     1140

atgtggaagc tttactacgc agaatatctc gtatatgtat tcatt                     1185


<210>  12
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized hexanoyl-CoA synthetase1

<400>  12
atgggtaaga actacaagtc tttggactcg gtggtcgcct cagattttat tgcattgggc       60

atcacctcag aggttgcgga aactcttcat ggcagactcg cagaaattgt ttgcaactac      120

ggcgcggcaa ccccacaaac gtggatcaat atcgctaatc acattttgtc gccggacttg      180

cctttttcat tgcatcagat gttgttttat ggttgttaca aggacttcgg tcccgcgcct      240

ccagcttgga ttccggatcc agaaaaggtc aagagtacca atctcggggc tttgcttgaa      300

aaacgaggaa aagaattcct tggcgtaaag tataaggatc ccatctctag cttttcgcac      360

ttccaggaat tcagtgtacg taatcctgag gtttactggc gtaccgttct tatggatgag      420

atgaaaattt cattttctaa ggaccccgaa tgtatccttc gtagagatga tattaacaat      480

ccagggggct cagaatggtt gccgggtggg taccttaatt ccgctaagaa ttgcttgaac      540

gtcaactcca acaaaaagct caacgacacc atgatcgttt ggcgagacga gggaaatgac      600

gacttgcctc ttaataagtt gacgctcgat caattgagaa agcgagtatg gctcgtaggc      660

tatgctctcg aggaaatggg tcttgagaag ggatgcgcga ttgcaatcga tatgccaatg      720

cacgtcgatg cagtagttat ttaccttgct atcgtgctcg ccggatatgt ggtggtatca      780

attgcagatt cgtttagtgc gcccgagatt tcaacccgcc ttcgcctttc aaaagccaaa      840

gccatcttca cccaagatca catcattagg ggaaagaaac gcatcccatt gtattcaagg      900

gttgtagaag cgaagagccc aatggcgatc gtaattccct gttccggttc caacatcggg      960

gcggaacttc gtgacggtga cattagttgg gattattttc tcgagagagc taaggaattt     1020

aaaaactgcg aattcactgc aagggagcag ccggttgacg cgtacacaaa tattctcttt     1080

tcctccggaa ctacggggga accaaaggcg atcccttgga cgcaagcgac accacttaag     1140

gcagccgccg acggttggtc ccaccttgat attaggaagg gggatgtcat cgtgtggcca     1200

actaacctcg gctggatgat gggaccgtgg ctcgtctatg cgtccctcct taacggagca     1260

tcgatcgcac tctacaatgg atctcctttg gtatcaggat tcgcgaagtt cgtacaggat     1320

gcaaaggtaa ccatgcttgg tgtggtacca tcaattgtga gaagctggaa aagcactaat     1380

tgcgtgagcg gttatgattg gtcaacaatt cgctgtttct cgtctagtgg agaggcgtcc     1440

aatgtagatg aatatctctg gcttatgggt agagccaact acaaaccagt tattgagatg     1500

tgcggcggaa ccgagattgg aggcgccttc agtgccggat ccttccttca ggcgcagtca     1560

ttgtcgtcct tctccagtca gtgtatgggc tgtactctct atattcttga caagaacgga     1620

tacccgatgc cgaagaacaa gcctggaatt ggtgagctcg cactcggacc agtaatgttt     1680

ggggcgtcaa aaactcttct caacggcaac catcacgatg tttattttaa gggtatgccg     1740

acccttaatg gtgaggtatt gcgccgccac ggtgacattt tcgagctcac ttcaaatgga     1800

tactaccacg cgcatgggcg agcagacgac acaatgaaca ttgggggaat taagatcagt     1860

tcgatcgaga ttgaaagagt gtgtaacgaa gttgacgaca gggtcttcga gaccacagcc     1920

atcggggtac ctccgctcgg tggcggcccg gagcagctcg tgattttttt tgtccttaaa     1980

gactcaaacg ataccactat cgatttgaat caacttagac tcagttttaa tctcggactt     2040

caaaaaaagt tgaaccccct cttcaaagtc accagagtgg tgcccctctc gagtcttccc     2100

cgcaccgcta caaataagat catgcgccga gttcttcgcc aacagttcag tcactttgaa     2160


<210>  13
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized tetrahydrocannabinolic acid synthase

<400>  13
atgaactgtt ccgctttcag cttttggttc gtgtgtaaaa tcatcttctt tttcctctca       60

ttccatattc agatctctat cgcaaacccg cgagagaatt tcctcaaatg cttctcgaaa      120

cacattccta ataatgtagc caatccaaaa cttgtgtata cgcagcacga tcagctctat      180

atgtccattc ttaactctac tatccagaac ttgagattca tctctgatac cacacccaag      240

ccgttggtga tcgtaacacc tagtaataat agtcacatcc aggcgacgat cctctgctca      300

aagaaggtag gactccaaat tagaacgaga tcgggcggac acgatgccga aggaatgagt      360

tatatctccc aagtaccgtt cgtagttgtt gaccttagga atatgcactc aattaagatt      420

gatgtccaca gtcaaacagc atgggttgag gcaggagcca ctcttggtga agtctactac      480

tggattaacg agaaaaatga gaacctctcg tttcctggcg gttactgtcc tacagtggga      540

gtgggaggtc atttttcggg cggaggatac ggggctttga tgagaaacta tgggcttgca      600

gcagataaca ttattgacgc ccacctcgtc aacgtagacg gtaaggtatt ggataggaag      660

tctatgggag aagacttgtt ctgggcgatt cgcggaggag gcggtgaaaa cttcggaatc      720

atcgcagcgt ggaaaatcaa actcgtagca gtgccatcga aaagtactat cttcagtgtt      780

aagaaaaaca tggaaatcca cggacttgtt aaacttttta acaaatggca aaacattgcc      840

tataagtatg ataaagattt ggtgctcatg actcacttca ttaccaagaa tattacagac      900

aaccacggta aaaataagac gactgtacat ggatacttta gctcgatttt ccacggcggc      960

gtcgacagcc ttgtagatct tatgaacaaa tcatttcccg aactcggaat taagaaaacg     1020

gactgtaagg aattcagttg gatcgatacc accatttttt actccggcgt cgttaatttc     1080

aacactgcca acttcaagaa ggaaattctc ctcgatagga gcgcgggtaa gaaaacagca     1140

ttttcgatta agttggatta tgttaaaaaa cccatccctg agactgccat ggtaaaaatt     1200

cttgaaaaac tctatgagga ggacgttggg gctggcatgt acgtacttta tccatacgga     1260

ggtatcatgg aggaaattag cgagtcggca atccccttcc cgcaccgcgc tggcatcatg     1320

tatgaacttt ggtacacagc aagctgggaa aagcaggaag ataacgaaaa acatatcaac     1380

tgggttaggt cagtctataa ctttacgacc ccctacgtgt cacagaatcc tagattggcg     1440

taccttaatt atcgtgacct tgacttgggc aagacgaacc acgcttcccc caacaactat     1500

actcaggctc gtatctgggg tgaaaaatat tttggaaaaa atttcaacag gttggtcaaa     1560

gtcaaaacca aggtggatcc gaacaatttc ttccgaaacg aacaatctat tccgccgctt     1620

ccaccgcacc accac                                                      1635


<210>  14
<211>  1632
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized cannabidiolic acid synthetase

<400>  14
atgaagtgtt ctacgttctc cttctggttc gtttgcaaaa tcattttctt cttctttagc       60

tttaatatcc agacttccat cgcgaacccg cgcgagaact tcctcaagtg cttctcacaa      120

tatattccga ataatgcgac gaaccttaag ctcgtatata cgcaaaataa tccactttac      180

atgagtgtgc tcaatagtac tattcataac ttgcgcttta cgtctgatac cacaccgaag      240

cccctcgtaa tcgtcacacc ttcacacgtg tcgcatattc aggggactat tttgtgctcg      300

aagaaggtgg gcttgcaaat cagaacgcgt tcaggaggtc atgactctga agggatgagc      360

tacatttcac aggtaccttt tgtgattgtc gacttgcgaa acatgagatc tatcaagatc      420

gacgtccata gccaaactgc gtgggtagaa gcgggcgcta cattggggga ggtgtattac      480

tgggtgaatg aaaagaacga gaacctctct ctcgctgccg gttactgccc cacagtctgt      540

gctggtggac actttggagg tggagggtac ggtcctctta tgcgaaacta tggattggct      600

gccgacaaca ttattgacgc tcacttggta aacgttcatg gtaaggtact tgaccgtaag      660

tctatgggcg aagacctctt ttgggcactt cgcggtggtg gcgctgaatc tttcggtatc      720

atcgtcgcgt ggaagattag attggtagcg gtccctaagt ccacaatgtt cagtgtgaaa      780

aagattatgg agatccacga acttgttaaa cttgtcaaca aatggcaaaa cattgcgtat      840

aagtacgaca aagatttgtt gctcatgacg cactttatca cacgaaacat cactgacaac      900

caggggaaga acaaaacagc aatccacacg tacttctcgt ctgtgttcct tggcggggta      960

gattcactcg tcgatctcat gaataaaagc ttcccggagt tggggattaa aaaaacagat     1020

tgcaggcaac tctcctggat cgatacaatt attttttaca gcggagtggt caattacgac     1080

acggacaact tcaataagga gatcctcctc gataggtcag ccgggcagaa cggagccttt     1140

aagatcaaac tcgattacgt caagaagccg atcccagagt ctgtatttgt tcaaattctt     1200

gaaaaacttt acgaagagga tattggggct gggatgtacg ctttgtatcc ttatgggggt     1260

attatggacg agatctcaga atcggcaatc cccttccccc atagggccgg aatcttgtac     1320

gaactttggt acatctgctc ctgggaaaag caggaggata acgagaagca cttgaactgg     1380

atcagaaaca tttataattt tatgacccct tacgtctcga aaaaccctcg acttgcctac     1440

ttgaattaca gggatctcga catcggtatt aatgacccta agaatccaaa taactatacg     1500

caggcccgta tttggggaga aaaatatttt ggtaagaact ttgatcgctt ggtcaaagtt     1560

aaaacgttgg ttgatcccaa taacttcttc agaaatgagc agtcgatccc cccattgcct     1620

agacatcgcc at                                                         1632


<210>  15
<211>  385
<212>  PRT
<213>  Cannabis sativa

<400>  15

Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr 
385 


<210>  16
<211>  101
<212>  PRT
<213>  Cannabis sativa

<400>  16

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  17
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OAC2

<400>  17

Met Lys Met Lys Ala Ala Trp Ser Ala Thr Ile Tyr Ser Leu Leu Ser 
1               5                   10                  15      


Trp Cys Val Val Lys Asn Glu Lys Phe Phe Pro Glu Arg Thr Ile Asp 
            20                  25                  30          


Ile Ser Lys Ser Asn Met Gly Arg Met Asn Asn Val Val Leu Asn Ser 
        35                  40                  45              


Leu His Thr Leu Lys Cys Tyr Leu Asn Tyr Val Ser Val Pro Phe Phe 
    50                  55                  60                  


Leu Ile Leu Leu Ser His Ile Phe Thr Pro Val Tyr Ile Phe His Gly 
65                  70                  75                  80  


Trp Asp Asp Ile His Lys Ile His Ile Arg Leu Glu Lys Phe Phe Leu 
                85                  90                  95      


Leu Gly Phe Cys Asp Phe Ile Phe Glu Leu Gln Tyr Asn Gln Met Leu 
            100                 105                 110         


His Cys His Ser Leu Ser Gln Leu Ser Ser Ser Ser Ser Phe 
        115                 120                 125     


<210>  18
<211>  403
<212>  PRT
<213>  Cannabis sativa

<400>  18

Met Gly Leu Ser Ser Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Asn Asn Pro Lys Thr Ser Leu Leu Cys 
            20                  25                  30          


Tyr Arg His Pro Lys Thr Pro Ile Lys Tyr Ser Tyr Asn Asn Phe Pro 
        35                  40                  45              


Ser Lys His Cys Ser Thr Lys Ser Phe His Leu Gln Asn Lys Cys Ser 
    50                  55                  60                  


Glu Ser Leu Ser Ile Ala Lys Asn Ser Ile Arg Ala Ala Thr Thr Asn 
65                  70                  75                  80  


Gln Thr Glu Pro Pro Glu Ser Asp Asn His Ser Val Ala Thr Lys Ile 
                85                  90                  95      


Leu Asn Phe Gly Lys Ala Cys Trp Lys Leu Gln Arg Pro Tyr Thr Ile 
            100                 105                 110         


Ile Ala Phe Thr Ser Cys Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu 
        115                 120                 125             


His Asn Thr Asn Leu Ile Ser Trp Ser Leu Met Phe Lys Ala Phe Phe 
    130                 135                 140                 


Phe Leu Val Ala Ile Leu Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn 
145                 150                 155                 160 


Gln Ile Tyr Asp Leu His Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
                165                 170                 175     


Leu Ala Ser Gly Glu Ile Ser Val Asn Thr Ala Trp Ile Met Ser Ile 
            180                 185                 190         


Ile Val Ala Leu Phe Gly Leu Ile Ile Thr Ile Lys Met Lys Gly Gly 
        195                 200                 205             


Pro Leu Tyr Ile Phe Gly Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val 
    210                 215                 220                 


Tyr Ser Val Pro Pro Phe Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe 
225                 230                 235                 240 


Leu Leu Asn Phe Leu Ala His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr 
                245                 250                 255     


Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe 
            260                 265                 270         


Thr Phe Leu Leu Ala Phe Met Lys Ser Met Gly Ser Ala Leu Ala Leu 
        275                 280                 285             


Ile Lys Asp Ala Ser Asp Val Glu Gly Asp Thr Lys Phe Gly Ile Ser 
    290                 295                 300                 


Thr Leu Ala Ser Lys Tyr Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser 
305                 310                 315                 320 


Gly Ile Val Leu Leu Ser Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile 
                325                 330                 335     


Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile 
            340                 345                 350         


Leu Ala Phe Trp Leu Ile Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn 
        355                 360                 365             


Tyr Asp Pro Glu Ala Gly Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu 
    370                 375                 380                 


Tyr Tyr Ala Glu Tyr Leu Val Tyr Val Phe Ile Asp Tyr Lys Asp Asp 
385                 390                 395                 400 


Asp Asp Lys 
            


<210>  19
<211>  720
<212>  PRT
<213>  Cannabis sativa

<400>  19

Met Gly Lys Asn Tyr Lys Ser Leu Asp Ser Val Val Ala Ser Asp Phe 
1               5                   10                  15      


Ile Ala Leu Gly Ile Thr Ser Glu Val Ala Glu Thr Leu His Gly Arg 
            20                  25                  30          


Leu Ala Glu Ile Val Cys Asn Tyr Gly Ala Ala Thr Pro Gln Thr Trp 
        35                  40                  45              


Ile Asn Ile Ala Asn His Ile Leu Ser Pro Asp Leu Pro Phe Ser Leu 
    50                  55                  60                  


His Gln Met Leu Phe Tyr Gly Cys Tyr Lys Asp Phe Gly Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Trp Ile Pro Asp Pro Glu Lys Val Lys Ser Thr Asn Leu Gly 
                85                  90                  95      


Ala Leu Leu Glu Lys Arg Gly Lys Glu Phe Leu Gly Val Lys Tyr Lys 
            100                 105                 110         


Asp Pro Ile Ser Ser Phe Ser His Phe Gln Glu Phe Ser Val Arg Asn 
        115                 120                 125             


Pro Glu Val Tyr Trp Arg Thr Val Leu Met Asp Glu Met Lys Ile Ser 
    130                 135                 140                 


Phe Ser Lys Asp Pro Glu Cys Ile Leu Arg Arg Asp Asp Ile Asn Asn 
145                 150                 155                 160 


Pro Gly Gly Ser Glu Trp Leu Pro Gly Gly Tyr Leu Asn Ser Ala Lys 
                165                 170                 175     


Asn Cys Leu Asn Val Asn Ser Asn Lys Lys Leu Asn Asp Thr Met Ile 
            180                 185                 190         


Val Trp Arg Asp Glu Gly Asn Asp Asp Leu Pro Leu Asn Lys Leu Thr 
        195                 200                 205             


Leu Asp Gln Leu Arg Lys Arg Val Trp Leu Val Gly Tyr Ala Leu Glu 
    210                 215                 220                 


Glu Met Gly Leu Glu Lys Gly Cys Ala Ile Ala Ile Asp Met Pro Met 
225                 230                 235                 240 


His Val Asp Ala Val Val Ile Tyr Leu Ala Ile Val Leu Ala Gly Tyr 
                245                 250                 255     


Val Val Val Ser Ile Ala Asp Ser Phe Ser Ala Pro Glu Ile Ser Thr 
            260                 265                 270         


Arg Leu Arg Leu Ser Lys Ala Lys Ala Ile Phe Thr Gln Asp His Ile 
        275                 280                 285             


Ile Arg Gly Lys Lys Arg Ile Pro Leu Tyr Ser Arg Val Val Glu Ala 
    290                 295                 300                 


Lys Ser Pro Met Ala Ile Val Ile Pro Cys Ser Gly Ser Asn Ile Gly 
305                 310                 315                 320 


Ala Glu Leu Arg Asp Gly Asp Ile Ser Trp Asp Tyr Phe Leu Glu Arg 
                325                 330                 335     


Ala Lys Glu Phe Lys Asn Cys Glu Phe Thr Ala Arg Glu Gln Pro Val 
            340                 345                 350         


Asp Ala Tyr Thr Asn Ile Leu Phe Ser Ser Gly Thr Thr Gly Glu Pro 
        355                 360                 365             


Lys Ala Ile Pro Trp Thr Gln Ala Thr Pro Leu Lys Ala Ala Ala Asp 
    370                 375                 380                 


Gly Trp Ser His Leu Asp Ile Arg Lys Gly Asp Val Ile Val Trp Pro 
385                 390                 395                 400 


Thr Asn Leu Gly Trp Met Met Gly Pro Trp Leu Val Tyr Ala Ser Leu 
                405                 410                 415     


Leu Asn Gly Ala Ser Ile Ala Leu Tyr Asn Gly Ser Pro Leu Val Ser 
            420                 425                 430         


Gly Phe Ala Lys Phe Val Gln Asp Ala Lys Val Thr Met Leu Gly Val 
        435                 440                 445             


Val Pro Ser Ile Val Arg Ser Trp Lys Ser Thr Asn Cys Val Ser Gly 
    450                 455                 460                 


Tyr Asp Trp Ser Thr Ile Arg Cys Phe Ser Ser Ser Gly Glu Ala Ser 
465                 470                 475                 480 


Asn Val Asp Glu Tyr Leu Trp Leu Met Gly Arg Ala Asn Tyr Lys Pro 
                485                 490                 495     


Val Ile Glu Met Cys Gly Gly Thr Glu Ile Gly Gly Ala Phe Ser Ala 
            500                 505                 510         


Gly Ser Phe Leu Gln Ala Gln Ser Leu Ser Ser Phe Ser Ser Gln Cys 
        515                 520                 525             


Met Gly Cys Thr Leu Tyr Ile Leu Asp Lys Asn Gly Tyr Pro Met Pro 
    530                 535                 540                 


Lys Asn Lys Pro Gly Ile Gly Glu Leu Ala Leu Gly Pro Val Met Phe 
545                 550                 555                 560 


Gly Ala Ser Lys Thr Leu Leu Asn Gly Asn His His Asp Val Tyr Phe 
                565                 570                 575     


Lys Gly Met Pro Thr Leu Asn Gly Glu Val Leu Arg Arg His Gly Asp 
            580                 585                 590         


Ile Phe Glu Leu Thr Ser Asn Gly Tyr Tyr His Ala His Gly Arg Ala 
        595                 600                 605             


Asp Asp Thr Met Asn Ile Gly Gly Ile Lys Ile Ser Ser Ile Glu Ile 
    610                 615                 620                 


Glu Arg Val Cys Asn Glu Val Asp Asp Arg Val Phe Glu Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Val Pro Pro Leu Gly Gly Gly Pro Glu Gln Leu Val Ile Phe 
                645                 650                 655     


Phe Val Leu Lys Asp Ser Asn Asp Thr Thr Ile Asp Leu Asn Gln Leu 
            660                 665                 670         


Arg Leu Ser Phe Asn Leu Gly Leu Gln Lys Lys Leu Asn Pro Leu Phe 
        675                 680                 685             


Lys Val Thr Arg Val Val Pro Leu Ser Ser Leu Pro Arg Thr Ala Thr 
    690                 695                 700                 


Asn Lys Ile Met Arg Arg Val Leu Arg Gln Gln Phe Ser His Phe Glu 
705                 710                 715                 720 


<210>  20
<211>  555
<212>  PRT
<213>  Cannabis sativa

<400>  20

Met Asn Cys Ser Ala Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Leu Ser Phe His Ile Gln Ile Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Lys His Ile Pro Asn Asn Val Ala Asn 
        35                  40                  45              


Pro Lys Leu Val Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Ile Leu 
    50                  55                  60                  


Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser Asn Asn Ser His Ile Gln Ala Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser Phe Pro Gly Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly Ala 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser Thr 
                245                 250                 255     


Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys Leu 
            260                 265                 270         


Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Val 
        275                 280                 285             


Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly Lys 
    290                 295                 300                 


Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly Gly 
305                 310                 315                 320 


Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly 
                325                 330                 335     


Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr Ile 
            340                 345                 350         


Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys Glu 
        355                 360                 365             


Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile Lys 
    370                 375                 380                 


Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Ala Gly Met Tyr Val Leu 
                405                 410                 415     


Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile Pro 
            420                 425                 430         


Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala Ser 
        435                 440                 445             


Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg Ser 
    450                 455                 460                 


Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu Ala 
465                 470                 475                 480 


Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn His Ala Ser 
                485                 490                 495     


Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly 
            500                 505                 510         


Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Val Asp Pro Asn 
        515                 520                 525             


Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His His 
    530                 535                 540                 


His Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
545                 550                 555 


<210>  21
<211>  544
<212>  PRT
<213>  Cannabis sativa

<400>  21

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6His

<400>  22
catcaccacc atcaccat                                                     18


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYC

<400>  23
gagcagaagc tcatttccga ggaggacctg                                        30


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLAG

<400>  24
gattacaagg atgatgatga caag                                              24


<210>  25
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V5

<400>  25
gggaagccca tccctaaccc tctcctgggg ctcgactcga cg                          42


<210>  26
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA

<400>  26
gggaagccca tccctaaccc tctcctgggg ctcgactcga cg                          42


<210>  27
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSV

<400>  27
cagcctgagc tcgcgcctga ggaccccgag gactgc                                 36


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6His

<400>  28
catcaccatc atcaccat                                                     18


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYC

<400>  29
gaacagaagc tcatttcaga agaggacttg                                        30


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLAG

<400>  30
gattacaaag acgacgacga caag                                              24


<210>  31
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V5

<400>  31
ggtaaaccga ttccgaatcc ccttttgggt ctcgactcca ca                          42


<210>  32
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA

<400>  32
tatccctatg acgtgccgga ctacgcc                                           27


<210>  33
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSV

<400>  33
caaccagagc ttgcacctga agaccctgag gattgc                                 36


<210>  34
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FBAC2-1

<400>  34
gtacgtacgc gtaacatatt gtagccaatt tggtgtcgac ggcatggtct cgcagggaac       60

gatagaaaaa cgttgacacc tagaaacggg ggctctggca cggcagctct ccacggattc      120

tctcgcagta ttacacgggc tatgcagtgg acagggatac caaacgtatg ttggtgtctt      180

aatgtaaact ttgcccgtaa attccgtcca tatcgatcga atccttaccg tcaagggaga      240

cctccagttc ccatggtcga ggggctttcg tggaccatcc cgccgcaaga tccatccgct      300

ggtgtgacgt cgagcagcgc cgaacggtgt cagtgacgtg gcatccctcc cccatccaca      360

gcaaacacga gtagttttgg tcgcgtttat accgcgctcc aaaccccaga attggccgtc      420

gcggttttcc gtaccgttgg tctcacactg gtcccgcgtt ttttctttga ttccacaatc      480

ag                                                                     482


<210>  35
<211>  136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUFA-1

<400>  35
gtaagactct gcaggctcca cgtgaacgag tacctcgaac ggtatggtac cgtcacaata       60

cacggtttct gcccttgtta gctcacacgt ttgctgtcct ttctactcgt tcttccctgt      120

tgttgatcct tgttag                                                      136


<210>  36
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EIF6-1

<400>  36
gtacgttttg ttgtggtcta ttgacaactg tagagtgcgt gaagcattta catcttgaaa       60

tggtacatct gacgcttttt gtcatcttga ag                                     92


<210>  37
<211>  196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPS4-1

<400>  37
gtaagaatac tcattcttcg tcaatgagat tgttgagtct ctgataggaa ccgaaaatgt       60

aggaaggaag cgctggcaac tttctgatga aagatgtttc tgatgaaaga cgtttgccgt      120

tgacaaacat ccgtcccacg aaagtagtgt cgggaaacgt tggctcactc ggttgattct      180

ttttctcctt taatag                                                      196


<210>  38
<211>  605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEF-1a

<400>  38
cgaaacgaat agaagctccc cgaggtcggg tgttgtttgg gaggttcatg gtggtttcgg       60

tgtcgcttgc tcgctcgctc gttcgcagtg acagacagtt cgtgagacac gagaaccgtt      120

ggcgtccgag ttcgggtgcc gcatttcgtc gtctccacga ttcaattctt gcccatcaga      180

cgagtcccga attccgtgac tctggatgcg atttactttc taactgtaag cgaaactcaa      240

cgattccgta cgttgttttc tattttacag tgagtcttcg ataccaccgt acaaccatcg      300

ttcgtgtacc gtctggtagt cccacgtgtc gacaacgtgt ggctctggac cgatgagttg      360

tttgccgttc ggaaacgagc agtaccaagg aattcacaga aacacagccc atgtaacaca      420

acgaccgcga atcgtttcgg tgctctcgct tcgcgtacgg gcgggcggtc ctcccgagca      480

gcgagaggag tccgcagcgt catagttgca atccgggccc ccctcgcgtt gttcactctc      540

tcgtctagta gagaaacttc catcggatcg tatcataata ttgtatcgta taatatcacg      600

taatc                                                                  605


<210>  39
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p40SRPS8

<400>  39
ccctgcgata gaccttttcc aaactcacgc agtccaagaa aacaaagggg tgagaagtat       60

acgcaccttt cggtttcggc ataattctta aactcttgtg gtcactttct tgtgaagaag      120

ctaggggcac tcgttttccc tcagagcctg caaacacaaa attcctgcag tcaattgtcc      180

caacactcgg caaaccgtat gcgcaagcaa cgatgcgcag aaggccgtgg atggatggcg      240

actcgcgata tggcttcttg ggtcgccagt gtggtacgtc cggcgtatgt caatacgcga      300

attcggacga ctggcatctc taggaggagg attccttctt ttatgacatg tttattttat      360

atacattgat gctttccgac agtcggaagt aataaatgaa tttatttcaa gactacctat      420

actcctttga cttgttcgac taatcttacc gcttactaaa atctcgaaat cacgcttgac      480

ctctcgcacg caaatttttg ctgctggacg ctacgcactc ggcccaattc ttctcggtcc      540

tcgtcgtcgc aattgtcgtt gcgttgatct tgcaccgaag gaatcagaga atagaatacc      600


<210>  40
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pH4-1B

<400>  40
cgtcggtctc tttcccggga aacgggtaca ctcctccgcg ccaacaacat attactacta       60

ctaccaagaa cgtccacggc cttgtcgtgc gttacgctct cccaacgcgt gcggggtaaa      120

ttacgtctcg gtttgctaag tagcgcacag ctaaatagat gaccgttatt gtatttaaga      180

tcattcaata ttgattgcat tgtactttgc gtcaaactga aattccctcg tactaacggt      240

taacccgtca accctaagcg ttcgcccaaa gtagtcaacc gggacacgcg aaccgacatt      300

gggcagatct ttcacagaca gaaaaccatt tccaatccaa ataagcatga ctattacaca      360

cccattcgta gcgcgaggac aaactgatag ctccaacaaa atgcgccaac atcgtacatt      420

gtaagaagct tacggaacac tatgtatgta gaaccatacg aacagcaact agtactggcc      480

atcgagcagc ggtgactccc ggctttcgta gcgctgtgaa ggttacactc tcacaattcg      540

ctctcggcta caaccgacaa aagtcttact cacagtcaat accgaaaaca aacaacagcc      600

aac                                                                    603


<210>  41
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  py-Tubulin

<400>  41
ttcgttgata tttttattca aatgtatcgg gaggagtaga ggttgattaa ctgtaaacaa       60

tttcctattt actgttaagg accagctgct gcagtaggta tggcctatcc actaaacgca      120

ctcacggaac gcctcgcgaa atttacccac ggccaactta cattaccgcc ttttgtgaat      180

tggaaacgcc gcatgattct caaatgcgca gaatttcaaa cggtagcttg cggtggagac      240

tcgctcattg acagtgaaac taccttgtgt cctcggattt tcagatatac ctatacagtt      300

catggcaaaa tttcgttcat gaacgcacgt gatccattgc tcgcgattcc cgtttttgat      360

tgtgaacgcg ggattacatg cgtgcggtga cggtagtcca gacacagata tttgcaatac      420

cgggcccttt tcactacaga ccctgtaggg gtatgttgac gagaatgaac tcgcagactg      480

ccaaaatcgc tttggctgat cccaagtttt ggcactccat cgtaatttgt catattccat      540

acggtagctt cgactgaatc cagacaaaca atttagtcca gctgcgcttc tacttgcaat      600


<210>  42
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pRBCMT

<400>  42
acacggagga tctatctaca gcagcgatga gggcgcccga gaaagaaaga acgattgccg       60

tactattctc tttgaccttt gggcgctcgc tcgtatcttt gaagcgactg ttggggtctc      120

agggtccaaa aaacagaaac tggattgaca gtgtgtctgg accttgtcga accttacagt      180

tacattacag ttaattgtca ctgtaaatag tctatcgctg gattacgtca tcgcgtgact      240

gggtgggaat ccttcttgtt gacagtgaat ctacggtata ctattccttg ggcgcttgta      300

cttgtgtctc gagattgccg acagtgacgt caattcggca cccacacctt ccacccgccg      360

aaccaaaatc aacaacacga agcacacgac cgaccgactg tacacgtgaa ggagcaaacc      420

atcgaacgaa aggagccttc cacggacaca acccgaaagc tcgacaccct tcacccacgc      480

aaagtatctc ttcgtgatcc tacc                                             504


<210>  43
<211>  250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFcpB

<400>  43
gaaacatacc ttcagcgtcg tcttcactgt cacagtcaac tgacagtaat ctttggcccg       60

tagaggttcg aaattcaatc tattaaatac agcaggataa gacacaagag cgacatcctg      120

acatcaactc cgtgaacagc aaatcctggt tgaacacgta tccttttggg ggcctccagc      180

tacgacgctc gccccagctg gggcttcctt actatacaca gcgcatattt cgcggttgcc      240

agaagtcaag                                                             250


<210>  44
<211>  599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFcpC

<400>  44
gagcacaaga ggtgacaaaa gccaccggct ggatcgcact tctcggaatt tcccccctac       60

tatcaaacaa attcgaattg ccaaaggtga agggactaac tgtaaatcct gatcaatcaa      120

ggtctcaatc aagtacaatg ggctacaatg atatttagat gggaacacaa tgaaacaaat      180

tgaaacttct actgacagga gcgcaattga cttgtgtagc ttttcatgag cacttgattg      240

ctaccaattg tgaacgggat ggggaaagac tcgaaaaggt gcatgcttcc gataatctac      300

tatattttct agaatcaaat aatatttaaa tgaatgaggt cctcagcgta cgttaagcct      360

acttatttag aacgagaagt cagaccgagg ggtactaaaa ttctaagggt tgagaggtat      420

cttgattccg ggtctatgga agcccatcct tgttgaagct tgaacacgat ccttgtgaaa      480

ggccgacgtt gcgcgaaaaa acagcctgcc gatttctttc cttctttctc gtctcaacct      540

atatactttc ataatctctg ttagagttta ccaacaacac atatatacat ttcgacaaa       599


<210>  45
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFcpD

<400>  45
actagcttga ttgggatatc tcgctcatgt ttgtcgcgtg ctatgtcttt ttaggtactt       60

tgaacctacg ttcgtacttg tataatatga tcatcgtatt atcgtttttc atccgtccag      120

cgcaaaatgc attagcagct agtcctagcg tgcggagcta cctggacagg tgcatgacgg      180

atgcgtgtcc ttcagtgact ttctaattaa cagtaacttc tttacttatg tttcagtttg      240

taagaagcgg gattcgctcg tcggttgaca tctgattgga ctgcgtcggc acatgaaaac      300

tacattgtga aatctgctaa aactccgggt atctctgaca caaaacgatt cggcttcgca      360

atttcaacat tacggtcaag gctaacgtat ctttctcggt caacttcaga ttatgccgat      420

taaattgtcg tagctttcaa ggcgttttga gtactgcggc agttgttgaa cctgcaagga      480

gaagatctcg acaacagaat aaagcgaaaa atgggtctca tgcactaaca ctcaggcctc      540

cctcataatc tctgtttgag tttaccaaca acacatatat acatttcgac aaa             593


<210>  46
<211>  499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEF-1a

<400>  46
atgcgggagt ggaccgcgac gatccgtccg gaaaacaata ctaggtgcta tcacaggggc       60

gcgttttgga gagacgttct gcggaaacac gaatttagaa tacgtaacta acatataaac      120

tggatagccc tcgcatcgga acttagaatg ttcgcctcaa tttttagttt agcgtggagc      180

agagatacct ttccatttgg caaaatctac ctttcgtgag ggacatcttg agaaataagc      240

ggacttgtag actaggaccg tggtaacctc ctctcaatct accaatgttg tctgatttcc      300

gagccgcgcg gctgaaaatc gtctagcact tggatgcgag agcaaatgtc aagtcctgct      360

ctgtcctgtt ggacgctttc ctctcaccgc gagagggctt tcactcgcga aacacgtatt      420

tcatattcaa actctatgaa gtttaaagta gatgtatcta caaacggtcc taagtttggg      480

taagaatttt cgactgcat                                                   499


<210>  47
<211>  499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  t40SRPS8

<400>  47
agataagaat atctcattgt gaacatctat gatttaccaa ttttattctt tgtttacagt       60

tagacgccag taattgtgct gtttctctca agtctgtgtc aatacaaact acgaaacttg      120

gcaatttttc tcttgaatat gagcacgaga ttgaaacgca caaaggaaat tagtttccat      180

cctttgacaa agtttgttgc tgtttagaga acagatgtca aaattaacgt gccatggaat      240

tgaaccatgg tgcgctatcc ccaaatcacg tcgtttgacc tcgtcacatt taaggtatat      300

caagcatatt cacttatatc ttgacatcct ccctgcttga tattcctttg cccttgagcc      360

atcttcccca cacgctggag atgacccctg cccctccttt ctttatccac ccgagtaagg      420

tgtcgacaag tcactttgcc cctgagccat cctccccact caggagatga cccctacccc      480

tttcttcttt atccacccc                                                   499


<210>  48
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tH4-1B

<400>  48
gcttgcgctt gatcctcgac tttgttgctc gtctttaaaa ccttggaacg attatataca       60

atcaccaact caaaaaccgg attttctaaa atccacccaa acaaccaaag aaaatacttc      120

tcattgcatt tatgaatcac agcagacctg cgtcctttta aaacttagat cctgttttct      180

tataaaaaac agatcaaatt ttctgggagt tcattgactc tgccagtcag aatcaatcct      240

gcagtaattc tttatttaca ggtgaaagta aaagagaatc ccaatttttt gcttgtacat      300

taaggtcctc cttacattac agctaatttc aaaataagat gaagttggat tcgtgtcctt      360

tcatggtgat gtgatattct gcactatacc aaacaccgtg aaatgtcagc tagagcttgt      420

catgaggcag ttgctgccaa tcactacata tagatccttc acggagaaaa gttggcttca      480

ttctctgttg ctaatcggct                                                  500


<210>  49
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ty-Tubulin

<400>  49
agcaaactca ttatgatgca tgggagtgcg accgagtttc gaacgatgct aacgaacatt       60

attagtggaa ggcagtcatt gttgtatgcg tcaaagtata taatcagacg gacagtagtt      120

cattttaaac ttttgttcgg aaagcgttga tcattcatcg gggaatcgcg ctaacgagca      180

gtaattggag ttgtaactgc aggctcaacg cgtttctggc tcccgtgggt taccataatg      240

ctaactatca ttctttattt gcagtatcac cagtccaaga attattcgtg gtcatttctg      300

atgctactgt ggagaagtga gagtaatttc gccgactttg aagtgaagac gcgtctccga      360

acgtagattg ttggtattgt accattgaag gagagttttt gaactcaggt tgttgatcgt      420

aatgtccgcg acatcctggc gcactacacg ccaatgacca taacatgtct tggtcgccct      480

cctcgtaagt catcgccatt                                                  500


<210>  50
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tRBCMT

<400>  50
aaatacaaat tcatgtacct aaacgatagt atggatgatg ggagtaattg cactataatt       60

gtagaacctt gtaagaggaa aaaatgatct tactgtgtta tttcctcttg aaagaatcta      120

tggataaaat aagagaggac gctaggtggt aacattccgg caaaacactg gcgcctaaat      180

ttttgccgga atcgtcaatt gcaacggttg taccggtgct ttgttttagt gtttcgcctt      240

gctacccttc aggaaccggt aacgaacacc tccgccaccc cggacccgct ctgttttagt      300

ttgaatggac ttgcgcaaag aatccttatc attcgcctgt gaccgggttc cttccttggc      360

caaatttgcc agaaaggttt cccgatcaat gctaggggtg cttccgcctc cacttgccgt      420

gggagtgttc ccaccgctac ttgccgttgg agtgctatca ctatcggagc cttggatcgt      480

gttgggcgta ccggtagtgc c                                                501


<210>  51
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tFcpB

<400>  51
tttacttgct gggtaggccg tttctggaat aacatattag attctaactg gttcgaagca       60

ttgcgttgct gtaacattcc cgttcacaaa aatacagaac agtctagaag ttcgcgacga      120

cataattttt ctctttagga ggccggggtt gtaattgttc tagggctgtt ccaatagaga      180

agataagatg atcaaacata ccagccgcgc ttgattggac ggagtacgtt tgcatcagct      240

atttttcaaa agcgctgcac gacgcacact ctatgaacac ttcaagactc tcaacgcaag      300

tgacaaccat cctctccaaa aggctatctt tcggggcacc tgtaatataa aaaagcatgg      360

cagtgcattc catgcaaaaa atgtctaatc tggttgggtt ttaaagtccg tatcgagcac      420

agaggtgaca aaagccaccg gctggatcgc acttctcgga atttcccccc tactatcaaa      480

caaattcgaa ttgccaaagg tg                                               502


<210>  52
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tFcpC

<400>  52
ttttgttaca ttgacttcaa ggagtcgagg aatcgatact gccgtcgttt ccaggatccg       60

aggtttctat agactctcta tagactctgt taacctaata gaatcagaca tacctctcct      120

gctattttgt ttttatgaat ttggcttttg cctctctagt cagatttgaa tgttattttc      180

cgccaggtgt gttagtcggg ctctcgtttg agttacaaga gggattgagt ggcgaggatt      240

cactctaatg taaatatgac tgtgaacaaa actttaaaat tactacgcat cttctttgac      300

tgtcagatat tcgtcggtga cagcagtcaa tgcctgcaaa ttgtcctcct gggtcgcaat      360

ttggttttgg attgacctgg tatgcattat gaagaaaaaa attcgttatt agccaactgc      420

ctagcgtgca cattgcatgg ttagacctcc ttgacgactg tgagcctaca tccttctgca      480

acaagctgca at                                                          492


<210>  53
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tFcpD

<400>  53
ttttgttaca tttactgact tcaaggagtc gaggaatcga tactgccgtc gtttccagga       60

tccgaggttt cataaactct gttaacgtta tagaaacaga cttacctctc ctacgccatt      120

cacgtaatat tcgcaatatg ctattcttcc tctgaagacc aggtttatgt gctgcctgaa      180

actatttcaa taagtcagct gcacttgcac agggtttcac aaggaaagcg tgtctttttt      240

tccaacgtag gcgtcgcttt cgtctgactc ttactcttac attcacagcc aatacttaca      300

attagtaaaa aacctgtgct cgagagtgaa aacgtc                                336


<210>  54
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMDV2a

<400>  54
gctcctgtca agcagaccct gaactttgac ctgctcaagc tcgccggtga tgtggagagc       60

aaccccggcc cc                                                           72


<210>  55
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMDV2a

<400>  55
gccccggtga aacaaaccct taatttcgat ttgttgaaat tggctggaga tgttgagtct       60

aatccaggcc cc                                                           72


<210>  56
<211>  9444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Steely1

<400>  56
atgaacaaga actcgaagat tcaatcgccg aactcgtcgg acgtggctgt gattggagtg       60

ggatttcgat ttccgggaaa ctcgaacgac ccggaatcgt tgtggaacaa cttgttggac      120

ggatttgacg ctattacgca agtgccgaag gaacgatggg ctacgtcgtt tcgagaaatg      180

ggattgatta agaacaagtt tggaggattt ttgaaggact cggaatggaa gaactttgac      240

ccgttgtttt ttggaattgg accgaaggaa gctccgttta ttgacccgca acaacgattg      300

ttgttgtcga ttgtgtggga atcgttggaa gacgcttaca ttcgaccgga cgaattgcga      360

ggatcgaaca cgggagtgtt tattggagtg tcgaacaacg actacacgaa gttgggattt      420

caagacaact actcgatttc gccgtacacg atgacgggat cgaactcgtc gttgaactcg      480

aaccgaattt cgtactgctt tgactttcga ggaccgtcga ttacggtgga cacggcttgc      540

tcgtcgtcgt tggtgtcggt gaacttggga gtgcaatcga ttcaaatggg agaatgcaag      600

attgctattt gcggaggagt gaacgctttg tttgacccgt cgacgtcggt ggctttttcg      660

aagttgggag tgttgtcgga aaacggacga tgcaactcgt tttcggacca agcttcggga      720

tacgtgcgat cggaaggagc tggagtggtg gtgttgaagt cgttggaaca agctaagttg      780

gacggagacc gaatttacgg agtgattaag ggagtgtcgt cgaacgaaga cggagcttcg      840

aacggagaca agaactcgtt gacgacgccg tcgtgcgaag ctcaatcgat taacatttcg      900

aaggctatgg aaaaggcttc gttgtcgccg tcggacattt actacattga agctcacgga      960

acgggaacgc cggtgggaga cccgattgaa gtgaaggctt tgtcgaagat tttttcgaac     1020

tcgaacaaca accaattgaa caacttttcg acggacggaa acgacaacga cgacgacgac     1080

gacgacaaca cgtcgccgga accgttgttg attggatcgt ttaagtcgaa cattggacac     1140

ttggaatcgg ctgctggaat tgcttcgttg attaagtgct gcttgatgtt gaagaaccga     1200

atgttggtgc cgtcgattaa ctgctcgaac ttgaacccgt cgattccgtt tgaccaatac     1260

aacatttcgg tgattcgaga aattcgacaa tttccgacgg acaagttggt gaacattgga     1320

attaactcgt ttggatttgg aggatcgaac tgccacttga ttattcaaga atacaacaac     1380

aactttaaga acaactcgac gatttgcaac aacaacaaca acaacaacaa caacattgac     1440

tacttgattc cgatttcgtc gaagacgaag aagtcgttgg acaagtactt gattttgatt     1500

aagacgaact cgaactacca caaggacatt tcgtttgacg actttgtgaa gtttcaaatt     1560

aagtcgaagc aatacaactt gtcgaaccga atgacgacga ttgctaacga ctggaactcg     1620

tttattaagg gatcgaacga atttcacaac ttgattgaat cgaaggacgg agaaggagga     1680

tcgtcgtcgt cgaaccgagg aattgactcg gctaaccaaa ttaacacgac gacgacgtcg     1740

acgattaacg acattgaacc gttgttggtg tttgtgtttt gcggacaagg accgcaatgg     1800

aacggaatga ttaagacgtt gtacaactcg gaaaacgtgt ttaagaacac ggtggaccac     1860

gtggactcga ttttgtacaa gtactttgga tactcgattt tgaacgtgtt gtcgaagatt     1920

gacgacaacg acgactcgat taaccacccg attgtggctc aaccgtcgtt gtttttgttg     1980

caaattggat tggtggaatt gtttaagtac tggggaattt acccgtcgat ttcggtggga     2040

cactcgtttg gagaagtgtc gtcgtactac ttgtcgggaa ttatttcgtt ggaaacggct     2100

tgcaagattg tgtacgtgcg atcgtcgaac caaaacaaga cgatgggatc gggaaagatg     2160

ttggtggtgt cgatgggatt taagcaatgg aacgaccaat tttcggctga atggtcggac     2220

attgaaattg cttgctacaa cgctccggac tcgattgtgg tgacgggaaa cgaagaacga     2280

ttgaaggaat tgtcgattaa gttgtcggac gaatcgaacc aaatttttaa cacgtttttg     2340

cgatcgccgt gctcgtttca ctcgtcgcac caagaagtga ttaagggatc gatgtttgaa     2400

gaattgtcga acttgcaatc gacgggagaa acggaaattc cgttgttttc gacggtgacg     2460

ggacgacaag tgttgtcggg acacgtgacg gctcaacaca tttacgacaa cgtgcgagaa     2520

ccggtgttgt ttcaaaagac gattgaatcg attacgtcgt acattaagtc gcactacccg     2580

tcgaaccaaa aggtgattta cgtggaaatt gctccgcacc cgacgttgtt ttcgttgatt     2640

aagaagtcga ttccgtcgtc gaacaagaac tcgtcgtcgg tgttgtgccc gttgaaccga     2700

aaggaaaact cgaacaactc gtacaagaag tttgtgtcgc aattgtactt taacggagtg     2760

aacgtggact ttaactttca attgaactcg atttgcgaca acgtgaacaa cgaccaccac     2820

ttgaacaacg tgaagcaaaa ctcgtttaag gaaacgacga actcgttgcc gcgataccaa     2880

tgggaacaag acgaatactg gtcggaaccg ttgatttcgc gaaagaaccg attggaagga     2940

ccgacgacgt cgttgttggg acaccgaatt atttactcgt ttccggtgtt tcaatcggtg     3000

ttggacttgc aatcggacaa ctacaagtac ttgttggacc acttggtgaa cggaaagccg     3060

gtgtttccgg gagctggata cttggacatt attattgaat tttttgacta ccaaaagcaa     3120

caattgaact cgtcggactc gtcgaactcg tacattatta acgtggacaa gattcaattt     3180

ttgaacccga ttcacttgac ggaaaacaag ttgcaaacgt tgcaatcgtc gtttgaaccg     3240

attgtgacga agaagtcggc tttttcggtg aactttttta ttaaggacac ggtggaagac     3300

caatcgaagg tgaagtcgat gtcggacgaa acgtggacga acacgtgcaa ggctacgatt     3360

tcgttggaac aacaacaacc gtcgccgtcg tcgacgttga cgttgtcgaa gaagcaagac     3420

ttgcaaattt tgcgaaaccg atgcgacatt tcgaagttgg acaagtttga attgtacgac     3480

aagatttcga agaacttggg attgcaatac aactcgttgt ttcaagtggt ggacacgatt     3540

gaaacgggaa aggactgctc gtttgctacg ttgtcgttgc cggaagacac gttgtttacg     3600

acgattttga acccgtgctt gttggacaac tgctttcacg gattgttgac gttgattaac     3660

gaaaagggat cgtttgtggt ggaatcgatt tcgtcggtgt cgatttactt ggaaaacatt     3720

ggatcgttta accaaacgtc ggtgggaaac gtgcaatttt acttgtacac gacgatttcg     3780

aaggctacgt cgttttcgtc ggaaggaacg tgcaagttgt ttacgaagga cggatcgttg     3840

attttgtcga ttggaaagtt tattattaag tcgacgaacc cgaagtcgac gaagacgaac     3900

gaaacgattg aatcgccgtt ggacgaaacg ttttcgattg aatggcaatc gaaggactcg     3960

ccgattccga cgccgcaaca aattcaacaa caatcgccgt tgaactcgaa cccgtcgttt     4020

attcgatcga cgattttgaa ggacattcaa tttgaacaat actgctcgtc gattattcac     4080

aaggaattga ttaaccacga aaagtacaag aaccaacaat cgtttgacat taactcgttg     4140

gaaaaccact tgaacgacga ccaattgatg gaatcgttgt cgatttcgaa ggaatacttg     4200

cgatttttta cgcgaattat ttcgattatt aagcaatacc cgaagatttt gaacgaaaag     4260

gaattgaagg aattgaagga aattattgaa ttgaagtacc cgtcggaagt gcaattgttg     4320

gaatttgaag tgattgaaaa ggtgtcgatg attattccga agttgttgtt tgaaaacgac     4380

aagcaatcgt cgatgacgtt gtttcaagac aacttgttga cgcgatttta ctcgaactcg     4440

aactcgacgc gattttactt ggaacgagtg tcggaaatgg tgttggaatc gattcgaccg     4500

attgtgcgag aaaagcgagt gtttcgaatt ttggaaattg gagctggaac gggatcgttg     4560

tcgaacgtgg tgttgacgaa gttgaacacg tacttgtcga cgttgaactc gaacggagga     4620

tcgggataca acattattat tgaatacacg tttacggaca tttcggctaa ctttattatt     4680

ggagaaattc aagaaacgat gtgcaacttg tacccgaacg tgacgtttaa gttttcggtg     4740

ttggacttgg aaaaggaaat tattaactcg tcggactttt tgatgggaga ctacgacatt     4800

gtgttgatgg cttacgtgat tcacgctgtg tcgaacatta agttttcgat tgaacaattg     4860

tacaagttgt tgtcgccgcg aggatggttg ttgtgcattg aaccgaagtc gaacgtggtg     4920

ttttcggact tggtgtttgg atgctttaac caatggtgga actactacga cgacattcga     4980

acgacgcact gctcgttgtc ggaatcgcaa tggaaccaat tgttgttgaa ccaatcgttg     5040

aacaacgaat cgtcgtcgtc gtcgaactgc tacggaggat tttcgaacgt gtcgtttatt     5100

ggaggagaaa aggacgtgga ctcgcactcg tttattttgc actgccaaaa ggaatcgatt     5160

tcgcaaatga agttggctac gacgattaac aacggattgt cgtcgggatc gattgtgatt     5220

gtgttgaact cgcaacaatt gacgaacatg aagtcgtacc cgaaggtgat tgaatacatt     5280

caagaagcta cgtcgttgtg caagacgatt gaaattattg actcgaagga cgtgttgaac     5340

tcgacgaact cggtgttgga aaagattcaa aagtcgttgt tggtgttttg cttgttggga     5400

tacgacttgt tggaaaacaa ctaccaagaa caatcgtttg aatacgtgaa gttgttgaac     5460

ttgatttcga cgacggcttc gtcgtcgaac gacaagaagc cgccgaaggt gttgttgatt     5520

acgaagcaat cggaacgaat ttcgcgatcg ttttactcgc gatcgttgat tggaatttcg     5580

cgaacgtcga tgaacgaata cccgaacttg tcgattacgt cgattgactt ggacacgaac     5640

gactactcgt tgcaatcgtt gttgaagccg attttttcga actcgaagtt ttcggacaac     5700

gaatttattt ttaagaaggg attgatgttt gtgtcgcgaa tttttaagaa caagcaattg     5760

ttggaatcgt cgaacgcttt tgaaacggac tcgtcgaact tgtactgcaa ggcttcgtcg     5820

gacttgtcgt acaagtacgc tattaagcaa tcgatgttga cggaaaacca aattgaaatt     5880

aaggtggaat gcgtgggaat taactttaag gacaacttgt tttacaaggg attgttgccg     5940

caagaaattt ttcgaatggg agacatttac aacccgccgt acggattgga atgctcggga     6000

gtgattacgc gaattggatc gaacgtgacg gaatactcgg tgggacaaaa cgtgtttgga     6060

tttgctcgac actcgttggg atcgcacgtg gtgacgaaca aggacttggt gattttgaag     6120

ccggacacga tttcgttttc ggaagctgct tcgattccgg tggtgtactg cacggcttgg     6180

tactcgttgt ttaacattgg acaattgtcg aacgaagaat cgattttgat tcactcggcc     6240

acgggaggag tgggattggc ttcgttgaac ttgttgaaga tgaagaacca acaacaacaa     6300

ccgttgacga acgtgtacgc tacggtggga tcgaacgaaa agaagaagtt tttgattgac     6360

aactttaaca acttgtttaa ggaagacgga gaaaacattt tttcgacgcg agacaaggaa     6420

tactcgaacc aattggaatc gaagattgac gtgattttga acacgttgtc gggagaattt     6480

gtggaatcga actttaagtc gttgcgatcg tttggacgat tgattgactt gtcggctacg     6540

cacgtgtacg ctaaccaaca aattggattg ggaaacttta agtttgacca cttgtactcg     6600

gctgtggact tggaacgatt gattgacgaa aagccgaagt tgttgcaatc gattttgcaa     6660

cgaattacga actcgattgt gaacggatcg ttggaaaaga ttccgattac gatttttccg     6720

tcgacggaaa cgaaggacgc tattgaattg ttgtcgaagc gatcgcacat tggaaaggtg     6780

gtggtggact gcacggacat ttcgaagtgc aacccggtgg gagacgtgat tacgaacttt     6840

tcgatgcgat tgccgaagcc gaactaccaa ttgaacttga actcgacgtt gttgattacg     6900

ggacaatcgg gattgtcgat tccgttgttg aactggttgt tgtcgaagtc gggaggaaac     6960

gtgaagaacg tggtgattat ttcgaagtcg acgatgaagt ggaagttgca aacgatgatt     7020

tcgcactttg tgtcgggatt tggaattcac tttaactacg tgcaagtgga catttcgaac     7080

tacgacgctt tgtcggaagc tattaagcaa ttgccgtcgg acttgccgcc gattacgtcg     7140

gtgtttcact tggctgctat ttacaacgac gtgccgatgg accaagtgac gatgtcgacg     7200

gtggaatcgg tgcacaaccc gaaggtgttg ggagctgtga acttgcaccg aatttcggtg     7260

tcgtttggat ggaagttgaa ccactttgtg ttgttttcgt cgattacggc tattacggga     7320

tacccggacc aatcgattta caactcggct aactcgattt tggacgcttt gtcgaacttt     7380

cgacgattta tgggattgcc gtcgttttcg attaacttgg gaccgatgaa ggacgaagga     7440

aaggtgtcga cgaacaagtc gattaagaag ttgtttaagt cgcgaggatt gccgtcgttg     7500

tcgttgaaca agttgtttgg attgttggaa gtggtgatta acaacccgtc gaaccacgtg     7560

attccgtcgc aattgatttg ctcgccgatt gactttaaga cgtacattga atcgttttcg     7620

acgatgcgac cgaagttgtt gcacttgcaa ccgacgattt cgaagcaaca atcgtcgatt     7680

attaacgact cgacgaaggc ttcgtcgaac atttcgttgc aagacaagat tacgtcgaag     7740

gtgtcggact tgttgtcgat tccgatttcg aagattaact ttgaccaccc gttgaagcac     7800

tacggattgg actcgttgtt gacggtgcaa tttaagtcgt ggattgacaa ggaatttgaa     7860

aagaacttgt ttacgcacat tcaattggct acgatttcga ttaactcgtt tttggaaaag     7920

gtgaacggat tgtcgacgaa caacaacaac aacaacaact cgaacgtgaa gtcgtcgccg     7980

tcgattgtga aggaagaaat tgtgacgttg gacaaggacc aacaaccgtt gttgttgaag     8040

gaacaccaac acattattat ttcgccggac attcgaatta acaagccgaa gcgagaatcg     8100

ttgattcgaa cgccgatttt gaacaagttt aaccaaatta cggaatcgat tattacgccg     8160

tcgacgccgt cgttgtcgca atcggacgtg ttgaagacgc cgccgattaa gtcgttgaac     8220

aacacgaaga actcgtcgtt gattaacacg ccgccgattc aatcggtgca acaacaccaa     8280

aagcaacaac aaaaggtgca agtgattcaa caacaacaac aaccgttgtc gcgattgtcg     8340

tacaagtcga acaacaactc gtttgtgttg ggaattggaa tttcggtgcc gggagaaccg     8400

atttcgcaac aatcgttgaa ggactcgatt tcgaacgact tttcggacaa ggctgaaacg     8460

aacgaaaagg tgaagcgaat ttttgaacaa tcgcaaatta agacgcgaca cttggtgcga     8520

gactacacga agccggaaaa ctcgattaag tttcgacact tggaaacgat tacggacgtg     8580

aacaaccaat ttaagaaggt ggtgccggac ttggctcaac aagcttgctt gcgagctttg     8640

aaggactggg gaggagacaa gggagacatt acgcacattg tgtcggtgac gtcgacggga     8700

attattattc cggacgtgaa ctttaagttg attgacttgt tgggattgaa caaggacgtg     8760

gaacgagtgt cgttgaactt gatgggatgc ttggctggat tgtcgtcgtt gcgaacggct     8820

gcttcgttgg ctaaggcttc gccgcgaaac cgaattttgg tggtgtgcac ggaagtgtgc     8880

tcgttgcact tttcgaacac ggacggagga gaccaaatgg tggcttcgtc gatttttgct     8940

gacggatcgg ctgcttacat tattggatgc aacccgcgaa ttgaagaaac gccgttgtac     9000

gaagtgatgt gctcgattaa ccgatcgttt ccgaacacgg aaaacgctat ggtgtgggac     9060

ttggaaaagg aaggatggaa cttgggattg gacgcttcga ttccgattgt gattggatcg     9120

ggaattgaag cttttgtgga cacgttgttg gacaaggcta agttgcaaac gtcgacggct     9180

atttcggcta aggactgcga atttttgatt cacacgggag gaaagtcgat tttgatgaac     9240

attgaaaact cgttgggaat tgacccgaag caaacgaaga acacgtggga cgtgtaccac     9300

gcttacggaa acatgtcgtc ggcttcggtg atttttgtga tggaccacgc tcgaaagtcg     9360

aagtcgttgc cgacgtactc gatttcgttg gcttttggac cgggattggc ttttgaagga     9420

tgctttttga agaacgtggt gtaa                                            9444


<210>  57
<211>  8907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Steely2

<400>  57
atgaacaaca acaagtcgat taacgacttg tcgggaaact cgaacaacaa cattgctaac       60

tcgaacatta acaactacaa caacttgatt aagaaggaac cgattgctat tattggaatt      120

ggatgccgat ttccgggaaa cgtgtcgaac tactcggact ttgtgaacat tattaagaac      180

ggatcggact gcttgacgaa gattccggac gaccgatgga acgctgacat tatttcgcga      240

aagcaatgga agttgaacaa ccgaattgga ggatacttga agaacattga ccaatttgac      300

aaccaatttt ttggaatttc gccgaaggaa gctcaacaca ttgacccgca acaacgattg      360

ttgttgcact tggctattga aacgttggaa gacggaaaga tttcgttgga cgaaattaag      420

ggaaagaagg tgggagtgtt tattggatcg tcgtcgggag actacttgcg aggatttgac      480

tcgtcggaaa ttaaccaatt tacgacgccg ggaacgaact cgtcgttttt gtcgaaccga      540

ttgtcgtact ttttggacgt gaacggaccg tcgatgacgg tgaacacggc ttgctcggct      600

tcgatggtgg ctattcactt gggattgcaa tcgttgtgga acggagaatc ggaattgtcg      660

atggtgggag gagtgaacat tatttcgtcg ccgttgcaat cgttggactt tggaaaggct      720

ggattgttga accaagaaac ggacggacga tgctactcgt ttgacccgcg agcttcggga      780

tacgtgcgat cggaaggagg aggaattttg ttgttgaagc cgttgtcggc tgctttgcga      840

gacaacgacg aaatttactc gttgttgttg aactcggcta acaactcgaa cggaaagacg      900

ccgacgggaa ttacgtcgcc gcgatcgttg tgccaagaaa agttgattca acaattgttg      960

cgagaatcgt cggaccaatt ttcgattgac gacattggat actttgaatg ccacggaacg     1020

ggaacgcaaa tgggagactt gaacgaaatt acggctattg gaaagtcgat tggaatgttg     1080

aagtcgcacg acgacccgtt gattattgga tcggtgaagg cttcgattgg acacttggaa     1140

ggagcttcgg gaatttgcgg agtgattaag tcgattattt gcttgaagga aaagattttg     1200

ccgcaacaat gcaagttttc gtcgtacaac ccgaagattc cgtttgaaac gttgaacttg     1260

aaggtgttga cgaagacgca accgtggaac aactcgaagc gaatttgcgg agtgaactcg     1320

tttggagtgg gaggatcgaa ctcgtcgttg tttttgtcgt cgtttgacaa gtcgacgacg     1380

attacggaac cgacgacgac gacgacgatt gaatcgttgc cgtcgtcgtc gtcgtcgttt     1440

gacaacttgt cggtgtcgtc gtcgatttcg acgaacaacg acaacgacaa ggtgtcgaac     1500

attgtgaaca accgatacgg atcgtcgatt gacgtgatta cgttgtcggt gacgtcgccg     1560

gacaaggaag acttgaagat tcgagctaac gacgtgttgg aatcgattaa gacgttggac     1620

gacaacttta agattcgaga catttcgaac ttgacgaaca ttcgaacgtc gcacttttcg     1680

aaccgagtgg ctattattgg agactcgatt gactcgatta agttgaactt gcaatcgttt     1740

attaagggag aaaacaacaa caacaagtcg attattttgc cgttgattaa caacggaaac     1800

aacaacaaca acaacaacaa caactcgtcg ggatcgtcgt cgtcgtcgtc gaacaacaac     1860

aacatttgct ttattttttc gggacaagga caacaatgga acaagatgat ttttgacttg     1920

tacgaaaaca acaagacgtt taagaacgaa atgaacaact tttcgaagca atttgaaatg     1980

atttcgggat ggtcgattat tgacaagttg tacaactcgg gaggaggagg aaacgaagaa     2040

ttgattaacg aaacgtggtt ggctcaaccg tcgattgtgg ctgtgcaata ctcgttgatt     2100

aagttgtttt cgaaggacat tggaattgaa ggatcgattg tgttgggaca ctcgttggga     2160

gaattgatgg ctgcttacta ctgcggaatt attaacgact ttaacgactt gttgaagttg     2220

ttgtacattc gatcgacgtt gcaaaacaag acgaacggat cgggacgaat gcacgtgtgc     2280

ttgtcgtcga aggctgaaat tgaacaattg atttcgcaat tgggatttaa cggacgaatt     2340

gtgatttgcg gaaacaacac gatgaagtcg tgcacgattt cgggagacaa cgaatcgatg     2400

aaccaattta cgaagttgat ttcgtcgcaa caatacggat cggtggtgca caaggaagtg     2460

cgaacgaact cggcttttca ctcgcaccaa atggacatta ttaaggacga attttttaag     2520

ttgtttaacc aatactttcc gacgaaccaa atttcgacga accaaattta cgacggaaag     2580

tcgttttact cgacgtgcta cggaaagtac ttgacgccga ttgaatgcaa gcaattgttg     2640

tcgtcgccga actactggtg gaagaacatt cgagaatcgg tgttgtttaa ggaatcgatt     2700

gaacaaattt tgcaaaacca ccaacaatcg ttgacgttta ttgaaattac gtgccacccg     2760

attttgaact actttttgtc gcaattgttg aagtcgtcgt cgaagtcgaa cacgttgttg     2820

ttgtcgacgt tgtcgaagaa ctcgaactcg attgaccaat tgttgatttt gtgctcgaag     2880

ttgtacgtga acaacttgtc gtcgattaag tggaactggt tttacgacaa gcaacaacaa     2940

caacaatcgg aatcgttggt gtcgtcgaac tttaagttgc cgggacgacg atggaagttg     3000

gaaaagtact ggattgaaaa ctgccaacga caaatggacc gaattaagcc gccgatgttt     3060

atttcgttgg accgaaagtt gttttcggtg acgccgtcgt ttgaagtgcg attgaaccaa     3120

gaccgatttc aatacttgaa cgaccaccaa attcaagaca ttccgttggt gccgttttcg     3180

ttttacattg aattggtgta cgcttcgatt tttaactcga tttcgacgac gacgacgaac     3240

acgacggctt cgacgatgtt tgaaattgaa aactttacga ttgactcgtc gattattatt     3300

gaccaaaaga agtcgacgtt gattggaatt aactttaact cggacttgac gaagtttgaa     3360

attggatcga ttaactcgat tggatcggga tcgtcgtcga acaacaactt tattgaaaac     3420

aagtggaaga ttcactcgaa cggaattatt aagtacggaa cgaactactt gaagtcgaac     3480

tcgaagtcga actcgtttaa cgaatcgacg acgacgacga cgacgacgac gacgacgacg     3540

aagtgcttta agtcgtttaa ctcgaacgaa ttttacaacg aaattattaa gtacaactac     3600

aactacaagt cgacgtttca atgcgtgaag gaatttaagc aatttgacaa gcaaggaacg     3660

ttttactact cggaaattca atttaagaag aacgacaagc aagtgattga ccaattgttg     3720

tcgaagcaat tgccgtcgga ctttcgatgc attcacccgt gcttgttgga cgctgtgttg     3780

caatcggcta ttattccggc tacgaacaag acgaactgct cgtggattcc gattaagatt     3840

ggaaagttgt cggtgaacat tccgtcgaac tcgtacttta actttaagga ccaattgttg     3900

tactgcttga ttaagccgtc gacgtcgacg tcgacgtcgc cgtcgacgta cttttcgtcg     3960

gacattcaag tgtttgacaa gaagaacaac aacttgattt gcgaattgac gaacttggaa     4020

tttaagggaa ttaactcgtc gtcgtcgtcg tcgtcgtcgt cgtcgacgat taactcgaac     4080

gtggaagcta actacgaatc gaagattgaa gaaacgaacc acgacgaaga cgaagacgaa     4140

gaattgccgt tggtgtcgga atacgtgtgg tgcaaggaag aattgattaa ccaatcgatt     4200

aagtttacgg acaactacca aacggtgatt ttttgctcga cgaacttgaa cggaaacgac     4260

ttgttggact cgattattac gtcggctttg gaaaacggac acgacgaaaa caagattttt     4320

attgtgtcgc cgccgccggt ggaatcggac caatacaaca accgaattat tattaactac     4380

acgaacaacg aatcggactt tgacgctttg tttgctatta ttaactcgac gacgtcgatt     4440

tcgggaaagt cgggattgtt ttcgacgcga tttattattt tgccgaactt taactcgatt     4500

acgttttcgt cgggaaactc gacgccgttg attacgaacg tgaacggaaa cggaaacgga     4560

aagtcgtgcg gaggaggagg aggatcgacg aacaacacga tttcgaactc gtcgtcgtcg     4620

atttcgtcga ttgacaacgg aaacaacgaa gacgaagaaa tggtgttgaa gtcgtttaac     4680

gactcgaact tgtcgttgtt tcacttgcaa aagtcgatta ttaagaacaa cattaaggga     4740

cgattgtttt tgattacgaa cggaggacaa tcgatttcgt cgtcgacgcc gacgtcgacg     4800

tacaacgacc aatcgtacgt gaacttgtcg caataccaat tgattggaca aattcgagtg     4860

ttttcgaacg aatacccgat tatggaatgc tcgatgattg acattcaaga ctcgacgcga     4920

attgacttga ttacggacca attgaactcg acgaagttgt cgaagttgga aattgctttt     4980

cgagacaaca ttggatactc gtacaagttg ttgaagccgt cgatttttga caactcgtcg     5040

ttgccgtcgt cgtcgtcgga aattgaaacg acggctacga cgaaggacga agaaaagaac     5100

aactcgatta actacaacaa caactactac cgagtggaat tgtcggacaa cggaattatt     5160

tcggacttga agattaagca atttcgacaa atgaagtgcg gagtgggaca agtgttggtg     5220

cgagtggaaa tgtgcacgtt gaactttcga gacattttga agtcgttggg acgagactac     5280

gacccgattc acttgaactc gatgggagac gaattttcgg gaaaggtgat tgaaattgga     5340

gaaggagtga acaacttgtc ggtgggacaa tacgtgtttg gaattaacat gtcgaagtcg     5400

atgggatcgt ttgtgtgctg caactcggac ttggtgtttc cgattccgat tccgacgccg     5460

tcgtcgtcgt cgtcgtcgaa cgaaaacatt gacgaccaag aaattatttc gaagttgttg     5520

aaccaatact gcacgattcc gattgtgttt ttgacgtcgt ggtactcgat tgtgattcaa     5580

ggacgattga agaagggaga aaagattttg attcactcgg gatgcggagg agtgggattg     5640

gctacgattc aaatttcgat gatgattgga gctgaaattc acgtgacggt gggatcgaac     5700

gaaaagaagc aatacttgat taaggaattt ggaattgacg aaaagcgaat ttactcgtcg     5760

cgatcgttgc aattttacaa cgacttgatg gtgaacacgg acggacaagg agtggacatg     5820

gtgttgaact cgttgtcggg agaatacttg gaaaagtcga ttcaatgctt gtcgcaatac     5880

ggacgattta ttgaaattgg aaagaaggac atttactcga actcgtcgat tcacttggaa     5940

ccgtttaaga acaacttgtc gttttttgct gtggacattg ctcaaatgac ggaaaaccga     6000

cgagactact tgcgagaaat tatgattgac caattgttgc cgtgctttaa gaacggatcg     6060

ttgaagccgt tgaaccaaca ctgctttaac tcgccgtgcg acttggtgaa ggctattcga     6120

tttatgtcgt cgggaaacca cattggaaag attttgatta actggtcgaa cttgaacaac     6180

gacaagcaat ttattaacca ccactcggtg gtgcacttgc cgattcaatc gttttcgaac     6240

cgatcgacgt acatttttac gggatttgga ggattgacgc aaacgttgtt gaagtacttt     6300

tcgacggaat cggacttgac gaacgtgatt attgtgtcga agaacggatt ggacgacaac     6360

tcgggatcgg gatcgggaaa caacgaaaag ttgaagttga ttaaccaatt gaaggaatcg     6420

ggattgaacg tgttggtgga aaagtgcgac ttgtcgtcga ttaagcaagt gtacaagttg     6480

tttaacaaga tttttgacaa cgacgcttcg ggatcggact cgggagactt ttcggacatt     6540

aagggaattt ttcactttgc ttcgttgatt aacgacaagc gaattttgaa gcacaacttg     6600

gaatcgttta actacgtgta caactcgaag gctacgtcgg cttggaactt gcaccaagtg     6660

tcgttgaagt acaacttgaa cttggaccac tttcaaacga ttggatcggt gattacgatt     6720

ttgggaaaca ttggacaatc gaactacacg tgcgctaacc gatttgtgga aggattgacg     6780

cacttgcgaa ttggaatggg attgaagtcg tcgtgcattc acttggcttc gattccggac     6840

gtgggaatgg cttcgaacga caacgtgttg aacgacttga actcgatggg atttgtgccg     6900

tttcaatcgt tgaacgaaat gaacttggga tttaagaagt tgttgtcgtc gccgaacccg     6960

attgtggtgt tgggagaaat taacgtggac cgatttattg aagctacgcc gaactttcga     7020

gctaaggaca actttattat tacgtcgttg tttaaccgaa ttgacccgtt gttgttggtg     7080

aacgaatcgc aagactttat tattaacaac aacattaaca acaacggagg aggaggagac     7140

ggatcgtttg acgacttgaa ccaattggaa gacgaaggac aacaaggatt tggaaacgga     7200

gacggatacg tggacgacaa cattgactcg gtgtcgatgt tgtcgggaac gtcgtcgatt     7260

tttgacaacg acttttacac gaagtcgatt cgaggaatgt tgtgcgacat tttggaattg     7320

aaggacaagg acttgaacaa cacggtgtcg ttttcggact acggattgga ctcgttgttg     7380

tcgtcggaat tgtcgaacac gattcaaaag aacttttcga ttttgattcc gtcgttgacg     7440

ttggtggaca actcgacgat taactcgacg gtggaattga ttaagaacaa gttgaagaac     7500

tcgacgacgt cgtcgatttc gtcgtcggtg tcgaagaagg tgtcgtttaa gaagaacacg     7560

caaccgttga ttattccgac gacggctccg atttcgatta ttaagacgca atcgtacatt     7620

aagtcggaaa ttattgaatc gttgccgatt tcgtcgtcga cgacgattaa gccgttggtg     7680

tttgacaact tggtgtactc gtcgtcgtcg tcgaacaact cgaactcgaa gaacgaattg     7740

acgtcgccgc cgccgtcggc taagcgagaa tcggtgttgc cgattatttc ggaagacaac     7800

aactcggaca acgactcgtc gatggctacg gtgatttacg aaatttcgcc gattgctgct     7860

ccgtaccacc gataccaaac ggacgtgttg aaggaaatta cgcaattgac gccgcacaag     7920

gaatttattg acaacattta caagaagtcg aagattcgat cgcgatactg ctttaacgac     7980

ttttcggaaa agtcgatggc tgacattaac aagttggacg ctggagaacg agtggctttg     8040

tttcgagaac aaacgtacca aacggtgatt aacgctggaa agacggtgat tgaacgagct     8100

ggaattgacc cgatgttgat ttcgcacgtg gtgggagtga cgtcgacggg aattatggct     8160

ccgtcgtttg acgtggtgtt gattgacaag ttgggattgt cgattaacac gtcgcgaacg     8220

atgattaact ttatgggatg cggagctgct gtgaactcga tgcgagctgc tacggcttac     8280

gctaagttga agccgggaac gtttgtgttg gtggtggctg tggaagcttc ggctacgtgc     8340

atgaagttta actttgactc gcgatcggac ttgttgtcgc aagctatttt tacggacgga     8400

tgcgtggcta cgttggtgac gtgccaaccg aagtcgtcgt tggtgggaaa gttggaaatt     8460

attgacgact tgtcgtactt gatgccggac tcgcgagacg ctttgaactt gtttattgga     8520

ccgacgggaa ttgacttgga cttgcgaccg gaattgccga ttgctattaa ccgacacatt     8580

aactcggcta ttacgtcgtg gttgaagaag aactcgttgc aaaagtcgga cattgaattt     8640

tttgctacgc acccgggagg agctaagatt atttcggctg tgcacgaagg attgggattg     8700

tcgccggaag acttgtcgga ctcgtacgaa gtgatgaagc gatacggaaa catgattgga     8760

gtgtcgacgt actacgtgtt gcgacgaatt ttggacaaga accaaacgtt gttgcaagaa     8820

ggatcgttgg gatacaacta cggaatggct atggcttttt cgccgggagc ttcgattgaa     8880

gctattttgt ttaagttgat taagtaa                                         8907


<210>  58
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Orf2

<400>  58
atgtcggaag ctgctgacgt ggaacgagtg tacgctgcta tggaagaagc tgctggattg       60

ttgggagtgg cttgcgctcg agacaagatt tacccgttgt tgtcgacgtt tcaagacacg      120

ttggtggaag gaggatcggt ggtggtgttt tcgatggctt cgggacgaca ctcgacggaa      180

ttggactttt cgatttcggt gccgacgtcg cacggagacc cgtacgctac ggtggtggaa      240

aagggattgt ttccggctac gggacacccg gtggacgact tgttggctga cacgcaaaag      300

cacttgccgg tgtcgatgtt tgctattgac ggagaagtga cgggaggatt taagaagacg      360

tacgcttttt ttccgacgga caacatgccg ggagtggctg aattgtcggc tattccgtcg      420

atgccgccgg ctgtggctga aaacgctgaa ttgtttgctc gatacggatt ggacaaggtg      480

caaatgacgt cgatggacta caagaagcga caagtgaact tgtacttttc ggaattgtcg      540

gctcaaacgt tggaagctga atcggtgttg gctttggtgc gagaattggg attgcacgtg      600

ccgaacgaat tgggattgaa gttttgcaag cgatcgtttt cggtgtaccc gacgttgaac      660

tgggaaacgg gaaagattga ccgattgtgc tttgctgtga tttcgaacga cccgacgttg      720

gtgccgtcgt cggacgaagg agacattgaa aagtttcaca actacgctac gaaggctccg      780

tacgcttacg tgggagaaaa gcgaacgttg gtgtacggat tgacgttgtc gccgaaggaa      840

gaatactaca agttgggagc ttactaccac attacggacg tgcaacgagg attgttgaag      900

gcttttgact cgttggaaga ctaa                                             924


<210>  59
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized CsPT4

<400>  59
atgggattgt cgttggtgtg cacgttttcg tttcaaacga actaccacac gttgttgaac       60

ccgcacaaca agaacccgaa gaactcgttg ttgtcgtacc aacacccgaa gacgccgatt      120

attaagtcgt cgtacgacaa ctttccgtcg aagtactgct tgacgaagaa ctttcacttg      180

ttgggattga actcgcacaa ccgaatttcg tcgcaatcgc gatcgattcg agctggatcg      240

gaccaaattg aaggatcgcc gcaccacgaa tcggacaact cgattgctac gaagattttg      300

aactttggac acacgtgctg gaagttgcaa cgaccgtacg tggtgaaggg aatgatttcg      360

attgcttgcg gattgtttgg acgagaattg tttaacaacc gacacttgtt ttcgtgggga      420

ttgatgtgga aggctttttt tgctttggtg ccgattttgt cgtttaactt ttttgctgct      480

attatgaacc aaatttacga cgtggacatt gaccgaatta acaagccgga cttgccgttg      540

gtgtcgggag aaatgtcgat tgaaacggct tggattttgt cgattattgt ggctttgacg      600

ggattgattg tgacgattaa gttgaagtcg gctccgttgt ttgtgtttat ttacattttt      660

ggaatttttg ctggatttgc ttactcggtg ccgccgattc gatggaagca atacccgttt      720

acgaactttt tgattacgat ttcgtcgcac gtgggattgg cttttacgtc gtactcggct      780

acgacgtcgg ctttgggatt gccgtttgtg tggcgaccgg ctttttcgtt tattattgct      840

tttatgacgg tgatgggaat gacgattgct tttgctaagg acatttcgga cattgaagga      900

gacgctaagt acggagtgtc gacggtggct acgaagttgg gagctcgaaa catgacgttt      960

gtggtgtcgg gagtgttgtt gttgaactac ttggtgtcga tttcgattgg aattatttgg     1020

ccgcaagtgt ttaagtcgaa cattatgatt ttgtcgcacg ctattttggc tttttgcttg     1080

atttttcaaa cgcgagaatt ggctttggct aactacgctt cggctccgtc gcgacaattt     1140

tttgaattta tttggttgtt gtactacgct gaatactttg tgtacgtgtt tatttaa        1197


<210>  60
<211>  1241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized HlPT4

<400>  60
atggaattgt cgtcggtgtc gtcgttttcg ttgggaacga acccgtttat ttcgattccg       60

cacaacaaca acaacttgaa ggtgtcgtcg tactgctgca agtcgaagtc gcgagtgatt      120

aactcgacga actcgaagca ctgctcgccg aacaacaact cgaacaacaa cacgtcgaac      180

aagacgacgc acttgttggg attgtacgga caatcgcgat gcttgttgaa gccgttgtcg      240

tttatttcgt gcaacgacca acgaggaaac tcgattcgag cttcggctca aattgaagac      300

cgaccgccgg aatcgggaaa cttgtcggct ttgacgaacg tgaaggactt tgtgtcggtg      360

tgctgggaat acgtgcgacc gtacacggct aagggagtga ttatttgctc gtcgtgcttg      420

tttggacgag aattgttgga aaacccgaac ttgttttcgt ggccgttgat ttttcgagct      480

ttgttgggaa tgttggctat tttgggatcg tgcttttaca cggctggaat taaccaaatt      540

tttgacatgg acattgaccg aattaacaag ccggacttgc cgttggtgtc gggacgaatt      600

tcggtggaat cggcttggtt gttgacgttg tcgccggcta ttattggatt tattttgatt      660

ttgaagttga actcgggacc gttgttgacg tcgttgtact gcttggctat tttgtcggga      720

acgatttact cggtgccgcc gtttcgatgg aagaagaacc cgattacggc ttttttgtgc      780

attttgatga ttcacgctgg attgaacttt tcggtgtact acgcttcgcg agctgctttg      840

ggattggctt ttgcttggtc gccgtcgttt tcgtttatta cggcttttat tacgtttatg      900

acgttgacgt tggcttcgtc gaaggacttg tcggacatta acggagaccg aaagtttgga      960

gtggaaacgt ttgctacgaa gttgggagct aagaacatta cgttgttggg aacgggattg     1020

ttgttgttga actacgtggc tgctatttcg acggctatta tttggccgaa ggcttttaag     1080

tcgaacatta tgttgttgtc gcacgctatt ttggcttttt cgttgatttt tcaagctcga     1140

gaattggacc gaacgaacta cacgccggaa gcttgcaagt cgttttacga atttatttgg     1200

attttgtttt cggctgaata cgtggtgtac ttgtttatta a                         1241


<210>  61
<211>  3147
<212>  PRT
<213>  Dictyostelium discoideum

<400>  61

Met Asn Lys Asn Ser Lys Ile Gln Ser Pro Asn Ser Ser Asp Val Ala 
1               5                   10                  15      


Val Ile Gly Val Gly Phe Arg Phe Pro Gly Asn Ser Asn Asp Pro Glu 
            20                  25                  30          


Ser Leu Trp Asn Asn Leu Leu Asp Gly Phe Asp Ala Ile Thr Gln Val 
        35                  40                  45              


Pro Lys Glu Arg Trp Ala Thr Ser Phe Arg Glu Met Gly Leu Ile Lys 
    50                  55                  60                  


Asn Lys Phe Gly Gly Phe Leu Lys Asp Ser Glu Trp Lys Asn Phe Asp 
65                  70                  75                  80  


Pro Leu Phe Phe Gly Ile Gly Pro Lys Glu Ala Pro Phe Ile Asp Pro 
                85                  90                  95      


Gln Gln Arg Leu Leu Leu Ser Ile Val Trp Glu Ser Leu Glu Asp Ala 
            100                 105                 110         


Tyr Ile Arg Pro Asp Glu Leu Arg Gly Ser Asn Thr Gly Val Phe Ile 
        115                 120                 125             


Gly Val Ser Asn Asn Asp Tyr Thr Lys Leu Gly Phe Gln Asp Asn Tyr 
    130                 135                 140                 


Ser Ile Ser Pro Tyr Thr Met Thr Gly Ser Asn Ser Ser Leu Asn Ser 
145                 150                 155                 160 


Asn Arg Ile Ser Tyr Cys Phe Asp Phe Arg Gly Pro Ser Ile Thr Val 
                165                 170                 175     


Asp Thr Ala Cys Ser Ser Ser Leu Val Ser Val Asn Leu Gly Val Gln 
            180                 185                 190         


Ser Ile Gln Met Gly Glu Cys Lys Ile Ala Ile Cys Gly Gly Val Asn 
        195                 200                 205             


Ala Leu Phe Asp Pro Ser Thr Ser Val Ala Phe Ser Lys Leu Gly Val 
    210                 215                 220                 


Leu Ser Glu Asn Gly Arg Cys Asn Ser Phe Ser Asp Gln Ala Ser Gly 
225                 230                 235                 240 


Tyr Val Arg Ser Glu Gly Ala Gly Val Val Val Leu Lys Ser Leu Glu 
                245                 250                 255     


Gln Ala Lys Leu Asp Gly Asp Arg Ile Tyr Gly Val Ile Lys Gly Val 
            260                 265                 270         


Ser Ser Asn Glu Asp Gly Ala Ser Asn Gly Asp Lys Asn Ser Leu Thr 
        275                 280                 285             


Thr Pro Ser Cys Glu Ala Gln Ser Ile Asn Ile Ser Lys Ala Met Glu 
    290                 295                 300                 


Lys Ala Ser Leu Ser Pro Ser Asp Ile Tyr Tyr Ile Glu Ala His Gly 
305                 310                 315                 320 


Thr Gly Thr Pro Val Gly Asp Pro Ile Glu Val Lys Ala Leu Ser Lys 
                325                 330                 335     


Ile Phe Ser Asn Ser Asn Asn Asn Gln Leu Asn Asn Phe Ser Thr Asp 
            340                 345                 350         


Gly Asn Asp Asn Asp Asp Asp Asp Asp Asp Asn Thr Ser Pro Glu Pro 
        355                 360                 365             


Leu Leu Ile Gly Ser Phe Lys Ser Asn Ile Gly His Leu Glu Ser Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ser Leu Ile Lys Cys Cys Leu Met Leu Lys Asn Arg 
385                 390                 395                 400 


Met Leu Val Pro Ser Ile Asn Cys Ser Asn Leu Asn Pro Ser Ile Pro 
                405                 410                 415     


Phe Asp Gln Tyr Asn Ile Ser Val Ile Arg Glu Ile Arg Gln Phe Pro 
            420                 425                 430         


Thr Asp Lys Leu Val Asn Ile Gly Ile Asn Ser Phe Gly Phe Gly Gly 
        435                 440                 445             


Ser Asn Cys His Leu Ile Ile Gln Glu Tyr Asn Asn Asn Phe Lys Asn 
    450                 455                 460                 


Asn Ser Thr Ile Cys Asn Asn Asn Asn Asn Asn Asn Asn Asn Ile Asp 
465                 470                 475                 480 


Tyr Leu Ile Pro Ile Ser Ser Lys Thr Lys Lys Ser Leu Asp Lys Tyr 
                485                 490                 495     


Leu Ile Leu Ile Lys Thr Asn Ser Asn Tyr His Lys Asp Ile Ser Phe 
            500                 505                 510         


Asp Asp Phe Val Lys Phe Gln Ile Lys Ser Lys Gln Tyr Asn Leu Ser 
        515                 520                 525             


Asn Arg Met Thr Thr Ile Ala Asn Asp Trp Asn Ser Phe Ile Lys Gly 
    530                 535                 540                 


Ser Asn Glu Phe His Asn Leu Ile Glu Ser Lys Asp Gly Glu Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Ser Asn Arg Gly Ile Asp Ser Ala Asn Gln Ile Asn Thr 
                565                 570                 575     


Thr Thr Thr Ser Thr Ile Asn Asp Ile Glu Pro Leu Leu Val Phe Val 
            580                 585                 590         


Phe Cys Gly Gln Gly Pro Gln Trp Asn Gly Met Ile Lys Thr Leu Tyr 
        595                 600                 605             


Asn Ser Glu Asn Val Phe Lys Asn Thr Val Asp His Val Asp Ser Ile 
    610                 615                 620                 


Leu Tyr Lys Tyr Phe Gly Tyr Ser Ile Leu Asn Val Leu Ser Lys Ile 
625                 630                 635                 640 


Asp Asp Asn Asp Asp Ser Ile Asn His Pro Ile Val Ala Gln Pro Ser 
                645                 650                 655     


Leu Phe Leu Leu Gln Ile Gly Leu Val Glu Leu Phe Lys Tyr Trp Gly 
            660                 665                 670         


Ile Tyr Pro Ser Ile Ser Val Gly His Ser Phe Gly Glu Val Ser Ser 
        675                 680                 685             


Tyr Tyr Leu Ser Gly Ile Ile Ser Leu Glu Thr Ala Cys Lys Ile Val 
    690                 695                 700                 


Tyr Val Arg Ser Ser Asn Gln Asn Lys Thr Met Gly Ser Gly Lys Met 
705                 710                 715                 720 


Leu Val Val Ser Met Gly Phe Lys Gln Trp Asn Asp Gln Phe Ser Ala 
                725                 730                 735     


Glu Trp Ser Asp Ile Glu Ile Ala Cys Tyr Asn Ala Pro Asp Ser Ile 
            740                 745                 750         


Val Val Thr Gly Asn Glu Glu Arg Leu Lys Glu Leu Ser Ile Lys Leu 
        755                 760                 765             


Ser Asp Glu Ser Asn Gln Ile Phe Asn Thr Phe Leu Arg Ser Pro Cys 
    770                 775                 780                 


Ser Phe His Ser Ser His Gln Glu Val Ile Lys Gly Ser Met Phe Glu 
785                 790                 795                 800 


Glu Leu Ser Asn Leu Gln Ser Thr Gly Glu Thr Glu Ile Pro Leu Phe 
                805                 810                 815     


Ser Thr Val Thr Gly Arg Gln Val Leu Ser Gly His Val Thr Ala Gln 
            820                 825                 830         


His Ile Tyr Asp Asn Val Arg Glu Pro Val Leu Phe Gln Lys Thr Ile 
        835                 840                 845             


Glu Ser Ile Thr Ser Tyr Ile Lys Ser His Tyr Pro Ser Asn Gln Lys 
    850                 855                 860                 


Val Ile Tyr Val Glu Ile Ala Pro His Pro Thr Leu Phe Ser Leu Ile 
865                 870                 875                 880 


Lys Lys Ser Ile Pro Ser Ser Asn Lys Asn Ser Ser Ser Val Leu Cys 
                885                 890                 895     


Pro Leu Asn Arg Lys Glu Asn Ser Asn Asn Ser Tyr Lys Lys Phe Val 
            900                 905                 910         


Ser Gln Leu Tyr Phe Asn Gly Val Asn Val Asp Phe Asn Phe Gln Leu 
        915                 920                 925             


Asn Ser Ile Cys Asp Asn Val Asn Asn Asp His His Leu Asn Asn Val 
    930                 935                 940                 


Lys Gln Asn Ser Phe Lys Glu Thr Thr Asn Ser Leu Pro Arg Tyr Gln 
945                 950                 955                 960 


Trp Glu Gln Asp Glu Tyr Trp Ser Glu Pro Leu Ile Ser Arg Lys Asn 
                965                 970                 975     


Arg Leu Glu Gly Pro Thr Thr Ser Leu Leu Gly His Arg Ile Ile Tyr 
            980                 985                 990         


Ser Phe Pro Val Phe Gln Ser Val  Leu Asp Leu Gln Ser  Asp Asn Tyr 
        995                 1000                 1005             


Lys Tyr  Leu Leu Asp His Leu  Val Asn Gly Lys Pro  Val Phe Pro 
    1010                 1015                 1020             


Gly Ala  Gly Tyr Leu Asp Ile  Ile Ile Glu Phe Phe  Asp Tyr Gln 
    1025                 1030                 1035             


Lys Gln  Gln Leu Asn Ser Ser  Asp Ser Ser Asn Ser  Tyr Ile Ile 
    1040                 1045                 1050             


Asn Val  Asp Lys Ile Gln Phe  Leu Asn Pro Ile His  Leu Thr Glu 
    1055                 1060                 1065             


Asn Lys  Leu Gln Thr Leu Gln  Ser Ser Phe Glu Pro  Ile Val Thr 
    1070                 1075                 1080             


Lys Lys  Ser Ala Phe Ser Val  Asn Phe Phe Ile Lys  Asp Thr Val 
    1085                 1090                 1095             


Glu Asp  Gln Ser Lys Val Lys  Ser Met Ser Asp Glu  Thr Trp Thr 
    1100                 1105                 1110             


Asn Thr  Cys Lys Ala Thr Ile  Ser Leu Glu Gln Gln  Gln Pro Ser 
    1115                 1120                 1125             


Pro Ser  Ser Thr Leu Thr Leu  Ser Lys Lys Gln Asp  Leu Gln Ile 
    1130                 1135                 1140             


Leu Arg  Asn Arg Cys Asp Ile  Ser Lys Leu Asp Lys  Phe Glu Leu 
    1145                 1150                 1155             


Tyr Asp  Lys Ile Ser Lys Asn  Leu Gly Leu Gln Tyr  Asn Ser Leu 
    1160                 1165                 1170             


Phe Gln  Val Val Asp Thr Ile  Glu Thr Gly Lys Asp  Cys Ser Phe 
    1175                 1180                 1185             


Ala Thr  Leu Ser Leu Pro Glu  Asp Thr Leu Phe Thr  Thr Ile Leu 
    1190                 1195                 1200             


Asn Pro  Cys Leu Leu Asp Asn  Cys Phe His Gly Leu  Leu Thr Leu 
    1205                 1210                 1215             


Ile Asn  Glu Lys Gly Ser Phe  Val Val Glu Ser Ile  Ser Ser Val 
    1220                 1225                 1230             


Ser Ile  Tyr Leu Glu Asn Ile  Gly Ser Phe Asn Gln  Thr Ser Val 
    1235                 1240                 1245             


Gly Asn  Val Gln Phe Tyr Leu  Tyr Thr Thr Ile Ser  Lys Ala Thr 
    1250                 1255                 1260             


Ser Phe  Ser Ser Glu Gly Thr  Cys Lys Leu Phe Thr  Lys Asp Gly 
    1265                 1270                 1275             


Ser Leu  Ile Leu Ser Ile Gly  Lys Phe Ile Ile Lys  Ser Thr Asn 
    1280                 1285                 1290             


Pro Lys  Ser Thr Lys Thr Asn  Glu Thr Ile Glu Ser  Pro Leu Asp 
    1295                 1300                 1305             


Glu Thr  Phe Ser Ile Glu Trp  Gln Ser Lys Asp Ser  Pro Ile Pro 
    1310                 1315                 1320             


Thr Pro  Gln Gln Ile Gln Gln  Gln Ser Pro Leu Asn  Ser Asn Pro 
    1325                 1330                 1335             


Ser Phe  Ile Arg Ser Thr Ile  Leu Lys Asp Ile Gln  Phe Glu Gln 
    1340                 1345                 1350             


Tyr Cys  Ser Ser Ile Ile His  Lys Glu Leu Ile Asn  His Glu Lys 
    1355                 1360                 1365             


Tyr Lys  Asn Gln Gln Ser Phe  Asp Ile Asn Ser Leu  Glu Asn His 
    1370                 1375                 1380             


Leu Asn  Asp Asp Gln Leu Met  Glu Ser Leu Ser Ile  Ser Lys Glu 
    1385                 1390                 1395             


Tyr Leu  Arg Phe Phe Thr Arg  Ile Ile Ser Ile Ile  Lys Gln Tyr 
    1400                 1405                 1410             


Pro Lys  Ile Leu Asn Glu Lys  Glu Leu Lys Glu Leu  Lys Glu Ile 
    1415                 1420                 1425             


Ile Glu  Leu Lys Tyr Pro Ser  Glu Val Gln Leu Leu  Glu Phe Glu 
    1430                 1435                 1440             


Val Ile  Glu Lys Val Ser Met  Ile Ile Pro Lys Leu  Leu Phe Glu 
    1445                 1450                 1455             


Asn Asp  Lys Gln Ser Ser Met  Thr Leu Phe Gln Asp  Asn Leu Leu 
    1460                 1465                 1470             


Thr Arg  Phe Tyr Ser Asn Ser  Asn Ser Thr Arg Phe  Tyr Leu Glu 
    1475                 1480                 1485             


Arg Val  Ser Glu Met Val Leu  Glu Ser Ile Arg Pro  Ile Val Arg 
    1490                 1495                 1500             


Glu Lys  Arg Val Phe Arg Ile  Leu Glu Ile Gly Ala  Gly Thr Gly 
    1505                 1510                 1515             


Ser Leu  Ser Asn Val Val Leu  Thr Lys Leu Asn Thr  Tyr Leu Ser 
    1520                 1525                 1530             


Thr Leu  Asn Ser Asn Gly Gly  Ser Gly Tyr Asn Ile  Ile Ile Glu 
    1535                 1540                 1545             


Tyr Thr  Phe Thr Asp Ile Ser  Ala Asn Phe Ile Ile  Gly Glu Ile 
    1550                 1555                 1560             


Gln Glu  Thr Met Cys Asn Leu  Tyr Pro Asn Val Thr  Phe Lys Phe 
    1565                 1570                 1575             


Ser Val  Leu Asp Leu Glu Lys  Glu Ile Ile Asn Ser  Ser Asp Phe 
    1580                 1585                 1590             


Leu Met  Gly Asp Tyr Asp Ile  Val Leu Met Ala Tyr  Val Ile His 
    1595                 1600                 1605             


Ala Val  Ser Asn Ile Lys Phe  Ser Ile Glu Gln Leu  Tyr Lys Leu 
    1610                 1615                 1620             


Leu Ser  Pro Arg Gly Trp Leu  Leu Cys Ile Glu Pro  Lys Ser Asn 
    1625                 1630                 1635             


Val Val  Phe Ser Asp Leu Val  Phe Gly Cys Phe Asn  Gln Trp Trp 
    1640                 1645                 1650             


Asn Tyr  Tyr Asp Asp Ile Arg  Thr Thr His Cys Ser  Leu Ser Glu 
    1655                 1660                 1665             


Ser Gln  Trp Asn Gln Leu Leu  Leu Asn Gln Ser Leu  Asn Asn Glu 
    1670                 1675                 1680             


Ser Ser  Ser Ser Ser Asn Cys  Tyr Gly Gly Phe Ser  Asn Val Ser 
    1685                 1690                 1695             


Phe Ile  Gly Gly Glu Lys Asp  Val Asp Ser His Ser  Phe Ile Leu 
    1700                 1705                 1710             


His Cys  Gln Lys Glu Ser Ile  Ser Gln Met Lys Leu  Ala Thr Thr 
    1715                 1720                 1725             


Ile Asn  Asn Gly Leu Ser Ser  Gly Ser Ile Val Ile  Val Leu Asn 
    1730                 1735                 1740             


Ser Gln  Gln Leu Thr Asn Met  Lys Ser Tyr Pro Lys  Val Ile Glu 
    1745                 1750                 1755             


Tyr Ile  Gln Glu Ala Thr Ser  Leu Cys Lys Thr Ile  Glu Ile Ile 
    1760                 1765                 1770             


Asp Ser  Lys Asp Val Leu Asn  Ser Thr Asn Ser Val  Leu Glu Lys 
    1775                 1780                 1785             


Ile Gln  Lys Ser Leu Leu Val  Phe Cys Leu Leu Gly  Tyr Asp Leu 
    1790                 1795                 1800             


Leu Glu  Asn Asn Tyr Gln Glu  Gln Ser Phe Glu Tyr  Val Lys Leu 
    1805                 1810                 1815             


Leu Asn  Leu Ile Ser Thr Thr  Ala Ser Ser Ser Asn  Asp Lys Lys 
    1820                 1825                 1830             


Pro Pro  Lys Val Leu Leu Ile  Thr Lys Gln Ser Glu  Arg Ile Ser 
    1835                 1840                 1845             


Arg Ser  Phe Tyr Ser Arg Ser  Leu Ile Gly Ile Ser  Arg Thr Ser 
    1850                 1855                 1860             


Met Asn  Glu Tyr Pro Asn Leu  Ser Ile Thr Ser Ile  Asp Leu Asp 
    1865                 1870                 1875             


Thr Asn  Asp Tyr Ser Leu Gln  Ser Leu Leu Lys Pro  Ile Phe Ser 
    1880                 1885                 1890             


Asn Ser  Lys Phe Ser Asp Asn  Glu Phe Ile Phe Lys  Lys Gly Leu 
    1895                 1900                 1905             


Met Phe  Val Ser Arg Ile Phe  Lys Asn Lys Gln Leu  Leu Glu Ser 
    1910                 1915                 1920             


Ser Asn  Ala Phe Glu Thr Asp  Ser Ser Asn Leu Tyr  Cys Lys Ala 
    1925                 1930                 1935             


Ser Ser  Asp Leu Ser Tyr Lys  Tyr Ala Ile Lys Gln  Ser Met Leu 
    1940                 1945                 1950             


Thr Glu  Asn Gln Ile Glu Ile  Lys Val Glu Cys Val  Gly Ile Asn 
    1955                 1960                 1965             


Phe Lys  Asp Asn Leu Phe Tyr  Lys Gly Leu Leu Pro  Gln Glu Ile 
    1970                 1975                 1980             


Phe Arg  Met Gly Asp Ile Tyr  Asn Pro Pro Tyr Gly  Leu Glu Cys 
    1985                 1990                 1995             


Ser Gly  Val Ile Thr Arg Ile  Gly Ser Asn Val Thr  Glu Tyr Ser 
    2000                 2005                 2010             


Val Gly  Gln Asn Val Phe Gly  Phe Ala Arg His Ser  Leu Gly Ser 
    2015                 2020                 2025             


His Val  Val Thr Asn Lys Asp  Leu Val Ile Leu Lys  Pro Asp Thr 
    2030                 2035                 2040             


Ile Ser  Phe Ser Glu Ala Ala  Ser Ile Pro Val Val  Tyr Cys Thr 
    2045                 2050                 2055             


Ala Trp  Tyr Ser Leu Phe Asn  Ile Gly Gln Leu Ser  Asn Glu Glu 
    2060                 2065                 2070             


Ser Ile  Leu Ile His Ser Ala  Thr Gly Gly Val Gly  Leu Ala Ser 
    2075                 2080                 2085             


Leu Asn  Leu Leu Lys Met Lys  Asn Gln Gln Gln Gln  Pro Leu Thr 
    2090                 2095                 2100             


Asn Val  Tyr Ala Thr Val Gly  Ser Asn Glu Lys Lys  Lys Phe Leu 
    2105                 2110                 2115             


Ile Asp  Asn Phe Asn Asn Leu  Phe Lys Glu Asp Gly  Glu Asn Ile 
    2120                 2125                 2130             


Phe Ser  Thr Arg Asp Lys Glu  Tyr Ser Asn Gln Leu  Glu Ser Lys 
    2135                 2140                 2145             


Ile Asp  Val Ile Leu Asn Thr  Leu Ser Gly Glu Phe  Val Glu Ser 
    2150                 2155                 2160             


Asn Phe  Lys Ser Leu Arg Ser  Phe Gly Arg Leu Ile  Asp Leu Ser 
    2165                 2170                 2175             


Ala Thr  His Val Tyr Ala Asn  Gln Gln Ile Gly Leu  Gly Asn Phe 
    2180                 2185                 2190             


Lys Phe  Asp His Leu Tyr Ser  Ala Val Asp Leu Glu  Arg Leu Ile 
    2195                 2200                 2205             


Asp Glu  Lys Pro Lys Leu Leu  Gln Ser Ile Leu Gln  Arg Ile Thr 
    2210                 2215                 2220             


Asn Ser  Ile Val Asn Gly Ser  Leu Glu Lys Ile Pro  Ile Thr Ile 
    2225                 2230                 2235             


Phe Pro  Ser Thr Glu Thr Lys  Asp Ala Ile Glu Leu  Leu Ser Lys 
    2240                 2245                 2250             


Arg Ser  His Ile Gly Lys Val  Val Val Asp Cys Thr  Asp Ile Ser 
    2255                 2260                 2265             


Lys Cys  Asn Pro Val Gly Asp  Val Ile Thr Asn Phe  Ser Met Arg 
    2270                 2275                 2280             


Leu Pro  Lys Pro Asn Tyr Gln  Leu Asn Leu Asn Ser  Thr Leu Leu 
    2285                 2290                 2295             


Ile Thr  Gly Gln Ser Gly Leu  Ser Ile Pro Leu Leu  Asn Trp Leu 
    2300                 2305                 2310             


Leu Ser  Lys Ser Gly Gly Asn  Val Lys Asn Val Val  Ile Ile Ser 
    2315                 2320                 2325             


Lys Ser  Thr Met Lys Trp Lys  Leu Gln Thr Met Ile  Ser His Phe 
    2330                 2335                 2340             


Val Ser  Gly Phe Gly Ile His  Phe Asn Tyr Val Gln  Val Asp Ile 
    2345                 2350                 2355             


Ser Asn  Tyr Asp Ala Leu Ser  Glu Ala Ile Lys Gln  Leu Pro Ser 
    2360                 2365                 2370             


Asp Leu  Pro Pro Ile Thr Ser  Val Phe His Leu Ala  Ala Ile Tyr 
    2375                 2380                 2385             


Asn Asp  Val Pro Met Asp Gln  Val Thr Met Ser Thr  Val Glu Ser 
    2390                 2395                 2400             


Val His  Asn Pro Lys Val Leu  Gly Ala Val Asn Leu  His Arg Ile 
    2405                 2410                 2415             


Ser Val  Ser Phe Gly Trp Lys  Leu Asn His Phe Val  Leu Phe Ser 
    2420                 2425                 2430             


Ser Ile  Thr Ala Ile Thr Gly  Tyr Pro Asp Gln Ser  Ile Tyr Asn 
    2435                 2440                 2445             


Ser Ala  Asn Ser Ile Leu Asp  Ala Leu Ser Asn Phe  Arg Arg Phe 
    2450                 2455                 2460             


Met Gly  Leu Pro Ser Phe Ser  Ile Asn Leu Gly Pro  Met Lys Asp 
    2465                 2470                 2475             


Glu Gly  Lys Val Ser Thr Asn  Lys Ser Ile Lys Lys  Leu Phe Lys 
    2480                 2485                 2490             


Ser Arg  Gly Leu Pro Ser Leu  Ser Leu Asn Lys Leu  Phe Gly Leu 
    2495                 2500                 2505             


Leu Glu  Val Val Ile Asn Asn  Pro Ser Asn His Val  Ile Pro Ser 
    2510                 2515                 2520             


Gln Leu  Ile Cys Ser Pro Ile  Asp Phe Lys Thr Tyr  Ile Glu Ser 
    2525                 2530                 2535             


Phe Ser  Thr Met Arg Pro Lys  Leu Leu His Leu Gln  Pro Thr Ile 
    2540                 2545                 2550             


Ser Lys  Gln Gln Ser Ser Ile  Ile Asn Asp Ser Thr  Lys Ala Ser 
    2555                 2560                 2565             


Ser Asn  Ile Ser Leu Gln Asp  Lys Ile Thr Ser Lys  Val Ser Asp 
    2570                 2575                 2580             


Leu Leu  Ser Ile Pro Ile Ser  Lys Ile Asn Phe Asp  His Pro Leu 
    2585                 2590                 2595             


Lys His  Tyr Gly Leu Asp Ser  Leu Leu Thr Val Gln  Phe Lys Ser 
    2600                 2605                 2610             


Trp Ile  Asp Lys Glu Phe Glu  Lys Asn Leu Phe Thr  His Ile Gln 
    2615                 2620                 2625             


Leu Ala  Thr Ile Ser Ile Asn  Ser Phe Leu Glu Lys  Val Asn Gly 
    2630                 2635                 2640             


Leu Ser  Thr Asn Asn Asn Asn  Asn Asn Asn Ser Asn  Val Lys Ser 
    2645                 2650                 2655             


Ser Pro  Ser Ile Val Lys Glu  Glu Ile Val Thr Leu  Asp Lys Asp 
    2660                 2665                 2670             


Gln Gln  Pro Leu Leu Leu Lys  Glu His Gln His Ile  Ile Ile Ser 
    2675                 2680                 2685             


Pro Asp  Ile Arg Ile Asn Lys  Pro Lys Arg Glu Ser  Leu Ile Arg 
    2690                 2695                 2700             


Thr Pro  Ile Leu Asn Lys Phe  Asn Gln Ile Thr Glu  Ser Ile Ile 
    2705                 2710                 2715             


Thr Pro  Ser Thr Pro Ser Leu  Ser Gln Ser Asp Val  Leu Lys Thr 
    2720                 2725                 2730             


Pro Pro  Ile Lys Ser Leu Asn  Asn Thr Lys Asn Ser  Ser Leu Ile 
    2735                 2740                 2745             


Asn Thr  Pro Pro Ile Gln Ser  Val Gln Gln His Gln  Lys Gln Gln 
    2750                 2755                 2760             


Gln Lys  Val Gln Val Ile Gln  Gln Gln Gln Gln Pro  Leu Ser Arg 
    2765                 2770                 2775             


Leu Ser  Tyr Lys Ser Asn Asn  Asn Ser Phe Val Leu  Gly Ile Gly 
    2780                 2785                 2790             


Ile Ser  Val Pro Gly Glu Pro  Ile Ser Gln Gln Ser  Leu Lys Asp 
    2795                 2800                 2805             


Ser Ile  Ser Asn Asp Phe Ser  Asp Lys Ala Glu Thr  Asn Glu Lys 
    2810                 2815                 2820             


Val Lys  Arg Ile Phe Glu Gln  Ser Gln Ile Lys Thr  Arg His Leu 
    2825                 2830                 2835             


Val Arg  Asp Tyr Thr Lys Pro  Glu Asn Ser Ile Lys  Phe Arg His 
    2840                 2845                 2850             


Leu Glu  Thr Ile Thr Asp Val  Asn Asn Gln Phe Lys  Lys Val Val 
    2855                 2860                 2865             


Pro Asp  Leu Ala Gln Gln Ala  Cys Leu Arg Ala Leu  Lys Asp Trp 
    2870                 2875                 2880             


Gly Gly  Asp Lys Gly Asp Ile  Thr His Ile Val Ser  Val Thr Ser 
    2885                 2890                 2895             


Thr Gly  Ile Ile Ile Pro Asp  Val Asn Phe Lys Leu  Ile Asp Leu 
    2900                 2905                 2910             


Leu Gly  Leu Asn Lys Asp Val  Glu Arg Val Ser Leu  Asn Leu Met 
    2915                 2920                 2925             


Gly Cys  Leu Ala Gly Leu Ser  Ser Leu Arg Thr Ala  Ala Ser Leu 
    2930                 2935                 2940             


Ala Lys  Ala Ser Pro Arg Asn  Arg Ile Leu Val Val  Cys Thr Glu 
    2945                 2950                 2955             


Val Cys  Ser Leu His Phe Ser  Asn Thr Asp Gly Gly  Asp Gln Met 
    2960                 2965                 2970             


Val Ala  Ser Ser Ile Phe Ala  Asp Gly Ser Ala Ala  Tyr Ile Ile 
    2975                 2980                 2985             


Gly Cys  Asn Pro Arg Ile Glu  Glu Thr Pro Leu Tyr  Glu Val Met 
    2990                 2995                 3000             


Cys Ser  Ile Asn Arg Ser Phe  Pro Asn Thr Glu Asn  Ala Met Val 
    3005                 3010                 3015             


Trp Asp  Leu Glu Lys Glu Gly  Trp Asn Leu Gly Leu  Asp Ala Ser 
    3020                 3025                 3030             


Ile Pro  Ile Val Ile Gly Ser  Gly Ile Glu Ala Phe  Val Asp Thr 
    3035                 3040                 3045             


Leu Leu  Asp Lys Ala Lys Leu  Gln Thr Ser Thr Ala  Ile Ser Ala 
    3050                 3055                 3060             


Lys Asp  Cys Glu Phe Leu Ile  His Thr Gly Gly Lys  Ser Ile Leu 
    3065                 3070                 3075             


Met Asn  Ile Glu Asn Ser Leu  Gly Ile Asp Pro Lys  Gln Thr Lys 
    3080                 3085                 3090             


Asn Thr  Trp Asp Val Tyr His  Ala Tyr Gly Asn Met  Ser Ser Ala 
    3095                 3100                 3105             


Ser Val  Ile Phe Val Met Asp  His Ala Arg Lys Ser  Lys Ser Leu 
    3110                 3115                 3120             


Pro Thr  Tyr Ser Ile Ser Leu  Ala Phe Gly Pro Gly  Leu Ala Phe 
    3125                 3130                 3135             


Glu Gly  Cys Phe Leu Lys Asn  Val Val 
    3140                 3145         


<210>  62
<211>  2968
<212>  PRT
<213>  Dictyostelium discoideum

<400>  62

Met Asn Asn Asn Lys Ser Ile Asn Asp Leu Ser Gly Asn Ser Asn Asn 
1               5                   10                  15      


Asn Ile Ala Asn Ser Asn Ile Asn Asn Tyr Asn Asn Leu Ile Lys Lys 
            20                  25                  30          


Glu Pro Ile Ala Ile Ile Gly Ile Gly Cys Arg Phe Pro Gly Asn Val 
        35                  40                  45              


Ser Asn Tyr Ser Asp Phe Val Asn Ile Ile Lys Asn Gly Ser Asp Cys 
    50                  55                  60                  


Leu Thr Lys Ile Pro Asp Asp Arg Trp Asn Ala Asp Ile Ile Ser Arg 
65                  70                  75                  80  


Lys Gln Trp Lys Leu Asn Asn Arg Ile Gly Gly Tyr Leu Lys Asn Ile 
                85                  90                  95      


Asp Gln Phe Asp Asn Gln Phe Phe Gly Ile Ser Pro Lys Glu Ala Gln 
            100                 105                 110         


His Ile Asp Pro Gln Gln Arg Leu Leu Leu His Leu Ala Ile Glu Thr 
        115                 120                 125             


Leu Glu Asp Gly Lys Ile Ser Leu Asp Glu Ile Lys Gly Lys Lys Val 
    130                 135                 140                 


Gly Val Phe Ile Gly Ser Ser Ser Gly Asp Tyr Leu Arg Gly Phe Asp 
145                 150                 155                 160 


Ser Ser Glu Ile Asn Gln Phe Thr Thr Pro Gly Thr Asn Ser Ser Phe 
                165                 170                 175     


Leu Ser Asn Arg Leu Ser Tyr Phe Leu Asp Val Asn Gly Pro Ser Met 
            180                 185                 190         


Thr Val Asn Thr Ala Cys Ser Ala Ser Met Val Ala Ile His Leu Gly 
        195                 200                 205             


Leu Gln Ser Leu Trp Asn Gly Glu Ser Glu Leu Ser Met Val Gly Gly 
    210                 215                 220                 


Val Asn Ile Ile Ser Ser Pro Leu Gln Ser Leu Asp Phe Gly Lys Ala 
225                 230                 235                 240 


Gly Leu Leu Asn Gln Glu Thr Asp Gly Arg Cys Tyr Ser Phe Asp Pro 
                245                 250                 255     


Arg Ala Ser Gly Tyr Val Arg Ser Glu Gly Gly Gly Ile Leu Leu Leu 
            260                 265                 270         


Lys Pro Leu Ser Ala Ala Leu Arg Asp Asn Asp Glu Ile Tyr Ser Leu 
        275                 280                 285             


Leu Leu Asn Ser Ala Asn Asn Ser Asn Gly Lys Thr Pro Thr Gly Ile 
    290                 295                 300                 


Thr Ser Pro Arg Ser Leu Cys Gln Glu Lys Leu Ile Gln Gln Leu Leu 
305                 310                 315                 320 


Arg Glu Ser Ser Asp Gln Phe Ser Ile Asp Asp Ile Gly Tyr Phe Glu 
                325                 330                 335     


Cys His Gly Thr Gly Thr Gln Met Gly Asp Leu Asn Glu Ile Thr Ala 
            340                 345                 350         


Ile Gly Lys Ser Ile Gly Met Leu Lys Ser His Asp Asp Pro Leu Ile 
        355                 360                 365             


Ile Gly Ser Val Lys Ala Ser Ile Gly His Leu Glu Gly Ala Ser Gly 
    370                 375                 380                 


Ile Cys Gly Val Ile Lys Ser Ile Ile Cys Leu Lys Glu Lys Ile Leu 
385                 390                 395                 400 


Pro Gln Gln Cys Lys Phe Ser Ser Tyr Asn Pro Lys Ile Pro Phe Glu 
                405                 410                 415     


Thr Leu Asn Leu Lys Val Leu Thr Lys Thr Gln Pro Trp Asn Asn Ser 
            420                 425                 430         


Lys Arg Ile Cys Gly Val Asn Ser Phe Gly Val Gly Gly Ser Asn Ser 
        435                 440                 445             


Ser Leu Phe Leu Ser Ser Phe Asp Lys Ser Thr Thr Ile Thr Glu Pro 
    450                 455                 460                 


Thr Thr Thr Thr Thr Ile Glu Ser Leu Pro Ser Ser Ser Ser Ser Phe 
465                 470                 475                 480 


Asp Asn Leu Ser Val Ser Ser Ser Ile Ser Thr Asn Asn Asp Asn Asp 
                485                 490                 495     


Lys Val Ser Asn Ile Val Asn Asn Arg Tyr Gly Ser Ser Ile Asp Val 
            500                 505                 510         


Ile Thr Leu Ser Val Thr Ser Pro Asp Lys Glu Asp Leu Lys Ile Arg 
        515                 520                 525             


Ala Asn Asp Val Leu Glu Ser Ile Lys Thr Leu Asp Asp Asn Phe Lys 
    530                 535                 540                 


Ile Arg Asp Ile Ser Asn Leu Thr Asn Ile Arg Thr Ser His Phe Ser 
545                 550                 555                 560 


Asn Arg Val Ala Ile Ile Gly Asp Ser Ile Asp Ser Ile Lys Leu Asn 
                565                 570                 575     


Leu Gln Ser Phe Ile Lys Gly Glu Asn Asn Asn Asn Lys Ser Ile Ile 
            580                 585                 590         


Leu Pro Leu Ile Asn Asn Gly Asn Asn Asn Asn Asn Asn Asn Asn Asn 
        595                 600                 605             


Ser Ser Gly Ser Ser Ser Ser Ser Ser Asn Asn Asn Asn Ile Cys Phe 
    610                 615                 620                 


Ile Phe Ser Gly Gln Gly Gln Gln Trp Asn Lys Met Ile Phe Asp Leu 
625                 630                 635                 640 


Tyr Glu Asn Asn Lys Thr Phe Lys Asn Glu Met Asn Asn Phe Ser Lys 
                645                 650                 655     


Gln Phe Glu Met Ile Ser Gly Trp Ser Ile Ile Asp Lys Leu Tyr Asn 
            660                 665                 670         


Ser Gly Gly Gly Gly Asn Glu Glu Leu Ile Asn Glu Thr Trp Leu Ala 
        675                 680                 685             


Gln Pro Ser Ile Val Ala Val Gln Tyr Ser Leu Ile Lys Leu Phe Ser 
    690                 695                 700                 


Lys Asp Ile Gly Ile Glu Gly Ser Ile Val Leu Gly His Ser Leu Gly 
705                 710                 715                 720 


Glu Leu Met Ala Ala Tyr Tyr Cys Gly Ile Ile Asn Asp Phe Asn Asp 
                725                 730                 735     


Leu Leu Lys Leu Leu Tyr Ile Arg Ser Thr Leu Gln Asn Lys Thr Asn 
            740                 745                 750         


Gly Ser Gly Arg Met His Val Cys Leu Ser Ser Lys Ala Glu Ile Glu 
        755                 760                 765             


Gln Leu Ile Ser Gln Leu Gly Phe Asn Gly Arg Ile Val Ile Cys Gly 
    770                 775                 780                 


Asn Asn Thr Met Lys Ser Cys Thr Ile Ser Gly Asp Asn Glu Ser Met 
785                 790                 795                 800 


Asn Gln Phe Thr Lys Leu Ile Ser Ser Gln Gln Tyr Gly Ser Val Val 
                805                 810                 815     


His Lys Glu Val Arg Thr Asn Ser Ala Phe His Ser His Gln Met Asp 
            820                 825                 830         


Ile Ile Lys Asp Glu Phe Phe Lys Leu Phe Asn Gln Tyr Phe Pro Thr 
        835                 840                 845             


Asn Gln Ile Ser Thr Asn Gln Ile Tyr Asp Gly Lys Ser Phe Tyr Ser 
    850                 855                 860                 


Thr Cys Tyr Gly Lys Tyr Leu Thr Pro Ile Glu Cys Lys Gln Leu Leu 
865                 870                 875                 880 


Ser Ser Pro Asn Tyr Trp Trp Lys Asn Ile Arg Glu Ser Val Leu Phe 
                885                 890                 895     


Lys Glu Ser Ile Glu Gln Ile Leu Gln Asn His Gln Gln Ser Leu Thr 
            900                 905                 910         


Phe Ile Glu Ile Thr Cys His Pro Ile Leu Asn Tyr Phe Leu Ser Gln 
        915                 920                 925             


Leu Leu Lys Ser Ser Ser Lys Ser Asn Thr Leu Leu Leu Ser Thr Leu 
    930                 935                 940                 


Ser Lys Asn Ser Asn Ser Ile Asp Gln Leu Leu Ile Leu Cys Ser Lys 
945                 950                 955                 960 


Leu Tyr Val Asn Asn Leu Ser Ser Ile Lys Trp Asn Trp Phe Tyr Asp 
                965                 970                 975     


Lys Gln Gln Gln Gln Gln Ser Glu Ser Leu Val Ser Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Gly Arg Arg Trp Lys Leu  Glu Lys Tyr Trp Ile  Glu Asn Cys 
        995                 1000                 1005             


Gln Arg  Gln Met Asp Arg Ile  Lys Pro Pro Met Phe  Ile Ser Leu 
    1010                 1015                 1020             


Asp Arg  Lys Leu Phe Ser Val  Thr Pro Ser Phe Glu  Val Arg Leu 
    1025                 1030                 1035             


Asn Gln  Asp Arg Phe Gln Tyr  Leu Asn Asp His Gln  Ile Gln Asp 
    1040                 1045                 1050             


Ile Pro  Leu Val Pro Phe Ser  Phe Tyr Ile Glu Leu  Val Tyr Ala 
    1055                 1060                 1065             


Ser Ile  Phe Asn Ser Ile Ser  Thr Thr Thr Thr Asn  Thr Thr Ala 
    1070                 1075                 1080             


Ser Thr  Met Phe Glu Ile Glu  Asn Phe Thr Ile Asp  Ser Ser Ile 
    1085                 1090                 1095             


Ile Ile  Asp Gln Lys Lys Ser  Thr Leu Ile Gly Ile  Asn Phe Asn 
    1100                 1105                 1110             


Ser Asp  Leu Thr Lys Phe Glu  Ile Gly Ser Ile Asn  Ser Ile Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Ser Asn Asn  Asn Phe Ile Glu Asn  Lys Trp Lys 
    1130                 1135                 1140             


Ile His  Ser Asn Gly Ile Ile  Lys Tyr Gly Thr Asn  Tyr Leu Lys 
    1145                 1150                 1155             


Ser Asn  Ser Lys Ser Asn Ser  Phe Asn Glu Ser Thr  Thr Thr Thr 
    1160                 1165                 1170             


Thr Thr  Thr Thr Thr Thr Thr  Lys Cys Phe Lys Ser  Phe Asn Ser 
    1175                 1180                 1185             


Asn Glu  Phe Tyr Asn Glu Ile  Ile Lys Tyr Asn Tyr  Asn Tyr Lys 
    1190                 1195                 1200             


Ser Thr  Phe Gln Cys Val Lys  Glu Phe Lys Gln Phe  Asp Lys Gln 
    1205                 1210                 1215             


Gly Thr  Phe Tyr Tyr Ser Glu  Ile Gln Phe Lys Lys  Asn Asp Lys 
    1220                 1225                 1230             


Gln Val  Ile Asp Gln Leu Leu  Ser Lys Gln Leu Pro  Ser Asp Phe 
    1235                 1240                 1245             


Arg Cys  Ile His Pro Cys Leu  Leu Asp Ala Val Leu  Gln Ser Ala 
    1250                 1255                 1260             


Ile Ile  Pro Ala Thr Asn Lys  Thr Asn Cys Ser Trp  Ile Pro Ile 
    1265                 1270                 1275             


Lys Ile  Gly Lys Leu Ser Val  Asn Ile Pro Ser Asn  Ser Tyr Phe 
    1280                 1285                 1290             


Asn Phe  Lys Asp Gln Leu Leu  Tyr Cys Leu Ile Lys  Pro Ser Thr 
    1295                 1300                 1305             


Ser Thr  Ser Thr Ser Pro Ser  Thr Tyr Phe Ser Ser  Asp Ile Gln 
    1310                 1315                 1320             


Val Phe  Asp Lys Lys Asn Asn  Asn Leu Ile Cys Glu  Leu Thr Asn 
    1325                 1330                 1335             


Leu Glu  Phe Lys Gly Ile Asn  Ser Ser Ser Ser Ser  Ser Ser Ser 
    1340                 1345                 1350             


Ser Ser  Thr Ile Asn Ser Asn  Val Glu Ala Asn Tyr  Glu Ser Lys 
    1355                 1360                 1365             


Ile Glu  Glu Thr Asn His Asp  Glu Asp Glu Asp Glu  Glu Leu Pro 
    1370                 1375                 1380             


Leu Val  Ser Glu Tyr Val Trp  Cys Lys Glu Glu Leu  Ile Asn Gln 
    1385                 1390                 1395             


Ser Ile  Lys Phe Thr Asp Asn  Tyr Gln Thr Val Ile  Phe Cys Ser 
    1400                 1405                 1410             


Thr Asn  Leu Asn Gly Asn Asp  Leu Leu Asp Ser Ile  Ile Thr Ser 
    1415                 1420                 1425             


Ala Leu  Glu Asn Gly His Asp  Glu Asn Lys Ile Phe  Ile Val Ser 
    1430                 1435                 1440             


Pro Pro  Pro Val Glu Ser Asp  Gln Tyr Asn Asn Arg  Ile Ile Ile 
    1445                 1450                 1455             


Asn Tyr  Thr Asn Asn Glu Ser  Asp Phe Asp Ala Leu  Phe Ala Ile 
    1460                 1465                 1470             


Ile Asn  Ser Thr Thr Ser Ile  Ser Gly Lys Ser Gly  Leu Phe Ser 
    1475                 1480                 1485             


Thr Arg  Phe Ile Ile Leu Pro  Asn Phe Asn Ser Ile  Thr Phe Ser 
    1490                 1495                 1500             


Ser Gly  Asn Ser Thr Pro Leu  Ile Thr Asn Val Asn  Gly Asn Gly 
    1505                 1510                 1515             


Asn Gly  Lys Ser Cys Gly Gly  Gly Gly Gly Ser Thr  Asn Asn Thr 
    1520                 1525                 1530             


Ile Ser  Asn Ser Ser Ser Ser  Ile Ser Ser Ile Asp  Asn Gly Asn 
    1535                 1540                 1545             


Asn Glu  Asp Glu Glu Met Val  Leu Lys Ser Phe Asn  Asp Ser Asn 
    1550                 1555                 1560             


Leu Ser  Leu Phe His Leu Gln  Lys Ser Ile Ile Lys  Asn Asn Ile 
    1565                 1570                 1575             


Lys Gly  Arg Leu Phe Leu Ile  Thr Asn Gly Gly Gln  Ser Ile Ser 
    1580                 1585                 1590             


Ser Ser  Thr Pro Thr Ser Thr  Tyr Asn Asp Gln Ser  Tyr Val Asn 
    1595                 1600                 1605             


Leu Ser  Gln Tyr Gln Leu Ile  Gly Gln Ile Arg Val  Phe Ser Asn 
    1610                 1615                 1620             


Glu Tyr  Pro Ile Met Glu Cys  Ser Met Ile Asp Ile  Gln Asp Ser 
    1625                 1630                 1635             


Thr Arg  Ile Asp Leu Ile Thr  Asp Gln Leu Asn Ser  Thr Lys Leu 
    1640                 1645                 1650             


Ser Lys  Leu Glu Ile Ala Phe  Arg Asp Asn Ile Gly  Tyr Ser Tyr 
    1655                 1660                 1665             


Lys Leu  Leu Lys Pro Ser Ile  Phe Asp Asn Ser Ser  Leu Pro Ser 
    1670                 1675                 1680             


Ser Ser  Ser Glu Ile Glu Thr  Thr Ala Thr Thr Lys  Asp Glu Glu 
    1685                 1690                 1695             


Lys Asn  Asn Ser Ile Asn Tyr  Asn Asn Asn Tyr Tyr  Arg Val Glu 
    1700                 1705                 1710             


Leu Ser  Asp Asn Gly Ile Ile  Ser Asp Leu Lys Ile  Lys Gln Phe 
    1715                 1720                 1725             


Arg Gln  Met Lys Cys Gly Val  Gly Gln Val Leu Val  Arg Val Glu 
    1730                 1735                 1740             


Met Cys  Thr Leu Asn Phe Arg  Asp Ile Leu Lys Ser  Leu Gly Arg 
    1745                 1750                 1755             


Asp Tyr  Asp Pro Ile His Leu  Asn Ser Met Gly Asp  Glu Phe Ser 
    1760                 1765                 1770             


Gly Lys  Val Ile Glu Ile Gly  Glu Gly Val Asn Asn  Leu Ser Val 
    1775                 1780                 1785             


Gly Gln  Tyr Val Phe Gly Ile  Asn Met Ser Lys Ser  Met Gly Ser 
    1790                 1795                 1800             


Phe Val  Cys Cys Asn Ser Asp  Leu Val Phe Pro Ile  Pro Ile Pro 
    1805                 1810                 1815             


Thr Pro  Ser Ser Ser Ser Ser  Ser Asn Glu Asn Ile  Asp Asp Gln 
    1820                 1825                 1830             


Glu Ile  Ile Ser Lys Leu Leu  Asn Gln Tyr Cys Thr  Ile Pro Ile 
    1835                 1840                 1845             


Val Phe  Leu Thr Ser Trp Tyr  Ser Ile Val Ile Gln  Gly Arg Leu 
    1850                 1855                 1860             


Lys Lys  Gly Glu Lys Ile Leu  Ile His Ser Gly Cys  Gly Gly Val 
    1865                 1870                 1875             


Gly Leu  Ala Thr Ile Gln Ile  Ser Met Met Ile Gly  Ala Glu Ile 
    1880                 1885                 1890             


His Val  Thr Val Gly Ser Asn  Glu Lys Lys Gln Tyr  Leu Ile Lys 
    1895                 1900                 1905             


Glu Phe  Gly Ile Asp Glu Lys  Arg Ile Tyr Ser Ser  Arg Ser Leu 
    1910                 1915                 1920             


Gln Phe  Tyr Asn Asp Leu Met  Val Asn Thr Asp Gly  Gln Gly Val 
    1925                 1930                 1935             


Asp Met  Val Leu Asn Ser Leu  Ser Gly Glu Tyr Leu  Glu Lys Ser 
    1940                 1945                 1950             


Ile Gln  Cys Leu Ser Gln Tyr  Gly Arg Phe Ile Glu  Ile Gly Lys 
    1955                 1960                 1965             


Lys Asp  Ile Tyr Ser Asn Ser  Ser Ile His Leu Glu  Pro Phe Lys 
    1970                 1975                 1980             


Asn Asn  Leu Ser Phe Phe Ala  Val Asp Ile Ala Gln  Met Thr Glu 
    1985                 1990                 1995             


Asn Arg  Arg Asp Tyr Leu Arg  Glu Ile Met Ile Asp  Gln Leu Leu 
    2000                 2005                 2010             


Pro Cys  Phe Lys Asn Gly Ser  Leu Lys Pro Leu Asn  Gln His Cys 
    2015                 2020                 2025             


Phe Asn  Ser Pro Cys Asp Leu  Val Lys Ala Ile Arg  Phe Met Ser 
    2030                 2035                 2040             


Ser Gly  Asn His Ile Gly Lys  Ile Leu Ile Asn Trp  Ser Asn Leu 
    2045                 2050                 2055             


Asn Asn  Asp Lys Gln Phe Ile  Asn His His Ser Val  Val His Leu 
    2060                 2065                 2070             


Pro Ile  Gln Ser Phe Ser Asn  Arg Ser Thr Tyr Ile  Phe Thr Gly 
    2075                 2080                 2085             


Phe Gly  Gly Leu Thr Gln Thr  Leu Leu Lys Tyr Phe  Ser Thr Glu 
    2090                 2095                 2100             


Ser Asp  Leu Thr Asn Val Ile  Ile Val Ser Lys Asn  Gly Leu Asp 
    2105                 2110                 2115             


Asp Asn  Ser Gly Ser Gly Ser  Gly Asn Asn Glu Lys  Leu Lys Leu 
    2120                 2125                 2130             


Ile Asn  Gln Leu Lys Glu Ser  Gly Leu Asn Val Leu  Val Glu Lys 
    2135                 2140                 2145             


Cys Asp  Leu Ser Ser Ile Lys  Gln Val Tyr Lys Leu  Phe Asn Lys 
    2150                 2155                 2160             


Ile Phe  Asp Asn Asp Ala Ser  Gly Ser Asp Ser Gly  Asp Phe Ser 
    2165                 2170                 2175             


Asp Ile  Lys Gly Ile Phe His  Phe Ala Ser Leu Ile  Asn Asp Lys 
    2180                 2185                 2190             


Arg Ile  Leu Lys His Asn Leu  Glu Ser Phe Asn Tyr  Val Tyr Asn 
    2195                 2200                 2205             


Ser Lys  Ala Thr Ser Ala Trp  Asn Leu His Gln Val  Ser Leu Lys 
    2210                 2215                 2220             


Tyr Asn  Leu Asn Leu Asp His  Phe Gln Thr Ile Gly  Ser Val Ile 
    2225                 2230                 2235             


Thr Ile  Leu Gly Asn Ile Gly  Gln Ser Asn Tyr Thr  Cys Ala Asn 
    2240                 2245                 2250             


Arg Phe  Val Glu Gly Leu Thr  His Leu Arg Ile Gly  Met Gly Leu 
    2255                 2260                 2265             


Lys Ser  Ser Cys Ile His Leu  Ala Ser Ile Pro Asp  Val Gly Met 
    2270                 2275                 2280             


Ala Ser  Asn Asp Asn Val Leu  Asn Asp Leu Asn Ser  Met Gly Phe 
    2285                 2290                 2295             


Val Pro  Phe Gln Ser Leu Asn  Glu Met Asn Leu Gly  Phe Lys Lys 
    2300                 2305                 2310             


Leu Leu  Ser Ser Pro Asn Pro  Ile Val Val Leu Gly  Glu Ile Asn 
    2315                 2320                 2325             


Val Asp  Arg Phe Ile Glu Ala  Thr Pro Asn Phe Arg  Ala Lys Asp 
    2330                 2335                 2340             


Asn Phe  Ile Ile Thr Ser Leu  Phe Asn Arg Ile Asp  Pro Leu Leu 
    2345                 2350                 2355             


Leu Val  Asn Glu Ser Gln Asp  Phe Ile Ile Asn Asn  Asn Ile Asn 
    2360                 2365                 2370             


Asn Asn  Gly Gly Gly Gly Asp  Gly Ser Phe Asp Asp  Leu Asn Gln 
    2375                 2380                 2385             


Leu Glu  Asp Glu Gly Gln Gln  Gly Phe Gly Asn Gly  Asp Gly Tyr 
    2390                 2395                 2400             


Val Asp  Asp Asn Ile Asp Ser  Val Ser Met Leu Ser  Gly Thr Ser 
    2405                 2410                 2415             


Ser Ile  Phe Asp Asn Asp Phe  Tyr Thr Lys Ser Ile  Arg Gly Met 
    2420                 2425                 2430             


Leu Cys  Asp Ile Leu Glu Leu  Lys Asp Lys Asp Leu  Asn Asn Thr 
    2435                 2440                 2445             


Val Ser  Phe Ser Asp Tyr Gly  Leu Asp Ser Leu Leu  Ser Ser Glu 
    2450                 2455                 2460             


Leu Ser  Asn Thr Ile Gln Lys  Asn Phe Ser Ile Leu  Ile Pro Ser 
    2465                 2470                 2475             


Leu Thr  Leu Val Asp Asn Ser  Thr Ile Asn Ser Thr  Val Glu Leu 
    2480                 2485                 2490             


Ile Lys  Asn Lys Leu Lys Asn  Ser Thr Thr Ser Ser  Ile Ser Ser 
    2495                 2500                 2505             


Ser Val  Ser Lys Lys Val Ser  Phe Lys Lys Asn Thr  Gln Pro Leu 
    2510                 2515                 2520             


Ile Ile  Pro Thr Thr Ala Pro  Ile Ser Ile Ile Lys  Thr Gln Ser 
    2525                 2530                 2535             


Tyr Ile  Lys Ser Glu Ile Ile  Glu Ser Leu Pro Ile  Ser Ser Ser 
    2540                 2545                 2550             


Thr Thr  Ile Lys Pro Leu Val  Phe Asp Asn Leu Val  Tyr Ser Ser 
    2555                 2560                 2565             


Ser Ser  Ser Asn Asn Ser Asn  Ser Lys Asn Glu Leu  Thr Ser Pro 
    2570                 2575                 2580             


Pro Pro  Ser Ala Lys Arg Glu  Ser Val Leu Pro Ile  Ile Ser Glu 
    2585                 2590                 2595             


Asp Asn  Asn Ser Asp Asn Asp  Ser Ser Met Ala Thr  Val Ile Tyr 
    2600                 2605                 2610             


Glu Ile  Ser Pro Ile Ala Ala  Pro Tyr His Arg Tyr  Gln Thr Asp 
    2615                 2620                 2625             


Val Leu  Lys Glu Ile Thr Gln  Leu Thr Pro His Lys  Glu Phe Ile 
    2630                 2635                 2640             


Asp Asn  Ile Tyr Lys Lys Ser  Lys Ile Arg Ser Arg  Tyr Cys Phe 
    2645                 2650                 2655             


Asn Asp  Phe Ser Glu Lys Ser  Met Ala Asp Ile Asn  Lys Leu Asp 
    2660                 2665                 2670             


Ala Gly  Glu Arg Val Ala Leu  Phe Arg Glu Gln Thr  Tyr Gln Thr 
    2675                 2680                 2685             


Val Ile  Asn Ala Gly Lys Thr  Val Ile Glu Arg Ala  Gly Ile Asp 
    2690                 2695                 2700             


Pro Met  Leu Ile Ser His Val  Val Gly Val Thr Ser  Thr Gly Ile 
    2705                 2710                 2715             


Met Ala  Pro Ser Phe Asp Val  Val Leu Ile Asp Lys  Leu Gly Leu 
    2720                 2725                 2730             


Ser Ile  Asn Thr Ser Arg Thr  Met Ile Asn Phe Met  Gly Cys Gly 
    2735                 2740                 2745             


Ala Ala  Val Asn Ser Met Arg  Ala Ala Thr Ala Tyr  Ala Lys Leu 
    2750                 2755                 2760             


Lys Pro  Gly Thr Phe Val Leu  Val Val Ala Val Glu  Ala Ser Ala 
    2765                 2770                 2775             


Thr Cys  Met Lys Phe Asn Phe  Asp Ser Arg Ser Asp  Leu Leu Ser 
    2780                 2785                 2790             


Gln Ala  Ile Phe Thr Asp Gly  Cys Val Ala Thr Leu  Val Thr Cys 
    2795                 2800                 2805             


Gln Pro  Lys Ser Ser Leu Val  Gly Lys Leu Glu Ile  Ile Asp Asp 
    2810                 2815                 2820             


Leu Ser  Tyr Leu Met Pro Asp  Ser Arg Asp Ala Leu  Asn Leu Phe 
    2825                 2830                 2835             


Ile Gly  Pro Thr Gly Ile Asp  Leu Asp Leu Arg Pro  Glu Leu Pro 
    2840                 2845                 2850             


Ile Ala  Ile Asn Arg His Ile  Asn Ser Ala Ile Thr  Ser Trp Leu 
    2855                 2860                 2865             


Lys Lys  Asn Ser Leu Gln Lys  Ser Asp Ile Glu Phe  Phe Ala Thr 
    2870                 2875                 2880             


His Pro  Gly Gly Ala Lys Ile  Ile Ser Ala Val His  Glu Gly Leu 
    2885                 2890                 2895             


Gly Leu  Ser Pro Glu Asp Leu  Ser Asp Ser Tyr Glu  Val Met Lys 
    2900                 2905                 2910             


Arg Tyr  Gly Asn Met Ile Gly  Val Ser Thr Tyr Tyr  Val Leu Arg 
    2915                 2920                 2925             


Arg Ile  Leu Asp Lys Asn Gln  Thr Leu Leu Gln Glu  Gly Ser Leu 
    2930                 2935                 2940             


Gly Tyr  Asn Tyr Gly Met Ala  Met Ala Phe Ser Pro  Gly Ala Ser 
    2945                 2950                 2955             


Ile Glu  Ala Ile Leu Phe Lys  Leu Ile Lys 
    2960                 2965             


<210>  63
<211>  307
<212>  PRT
<213>  Streptomyces sp. strain CL190

<400>  63

Met Ser Glu Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Ala Cys Ala Arg Asp Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Ser Thr Phe Gln Asp Thr Leu Val Glu Gly Gly Ser Val Val 
        35                  40                  45              


Val Phe Ser Met Ala Ser Gly Arg His Ser Thr Glu Leu Asp Phe Ser 
    50                  55                  60                  


Ile Ser Val Pro Thr Ser His Gly Asp Pro Tyr Ala Thr Val Val Glu 
65                  70                  75                  80  


Lys Gly Leu Phe Pro Ala Thr Gly His Pro Val Asp Asp Leu Leu Ala 
                85                  90                  95      


Asp Thr Gln Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu 
            100                 105                 110         


Val Thr Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asn 
        115                 120                 125             


Met Pro Gly Val Ala Glu Leu Ser Ala Ile Pro Ser Met Pro Pro Ala 
    130                 135                 140                 


Val Ala Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val 
145                 150                 155                 160 


Gln Met Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe 
                165                 170                 175     


Ser Glu Leu Ser Ala Gln Thr Leu Glu Ala Glu Ser Val Leu Ala Leu 
            180                 185                 190         


Val Arg Glu Leu Gly Leu His Val Pro Asn Glu Leu Gly Leu Lys Phe 
        195                 200                 205             


Cys Lys Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Glu Thr Gly 
    210                 215                 220                 


Lys Ile Asp Arg Leu Cys Phe Ala Val Ile Ser Asn Asp Pro Thr Leu 
225                 230                 235                 240 


Val Pro Ser Ser Asp Glu Gly Asp Ile Glu Lys Phe His Asn Tyr Ala 
                245                 250                 255     


Thr Lys Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr 
            260                 265                 270         


Gly Leu Thr Leu Ser Pro Lys Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr 
        275                 280                 285             


Tyr His Ile Thr Asp Val Gln Arg Gly Leu Leu Lys Ala Phe Asp Ser 
    290                 295                 300                 


Leu Glu Asp 
305         


<210>  64
<211>  398
<212>  PRT
<213>  Cannabis sativa

<400>  64

Met Gly Leu Ser Leu Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Lys Asn Pro Lys Asn Ser Leu Leu Ser 
            20                  25                  30          


Tyr Gln His Pro Lys Thr Pro Ile Ile Lys Ser Ser Tyr Asp Asn Phe 
        35                  40                  45              


Pro Ser Lys Tyr Cys Leu Thr Lys Asn Phe His Leu Leu Gly Leu Asn 
    50                  55                  60                  


Ser His Asn Arg Ile Ser Ser Gln Ser Arg Ser Ile Arg Ala Gly Ser 
65                  70                  75                  80  


Asp Gln Ile Glu Gly Ser Pro His His Glu Ser Asp Asn Ser Ile Ala 
                85                  90                  95      


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
            100                 105                 110         


Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg 
        115                 120                 125             


Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys 
    130                 135                 140                 


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
145                 150                 155                 160 


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
                165                 170                 175     


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
            180                 185                 190         


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
        195                 200                 205             


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
    210                 215                 220                 


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe 
225                 230                 235                 240 


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
                245                 250                 255     


Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg 
            260                 265                 270         


Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr 
        275                 280                 285             


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
    290                 295                 300                 


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
305                 310                 315                 320 


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile 
                325                 330                 335     


Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser 
            340                 345                 350         


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
        355                 360                 365             


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
    370                 375                 380                 


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
385                 390                 395             


<210>  65
<211>  413
<212>  PRT
<213>  Humulus lupulus

<400>  65

Met Glu Leu Ser Ser Val Ser Ser Phe Ser Leu Gly Thr Asn Pro Phe 
1               5                   10                  15      


Ile Ser Ile Pro His Asn Asn Asn Asn Leu Lys Val Ser Ser Tyr Cys 
            20                  25                  30          


Cys Lys Ser Lys Ser Arg Val Ile Asn Ser Thr Asn Ser Lys His Cys 
        35                  40                  45              


Ser Pro Asn Asn Asn Ser Asn Asn Asn Thr Ser Asn Lys Thr Thr His 
    50                  55                  60                  


Leu Leu Gly Leu Tyr Gly Gln Ser Arg Cys Leu Leu Lys Pro Leu Ser 
65                  70                  75                  80  


Phe Ile Ser Cys Asn Asp Gln Arg Gly Asn Ser Ile Arg Ala Ser Ala 
                85                  90                  95      


Gln Ile Glu Asp Arg Pro Pro Glu Ser Gly Asn Leu Ser Ala Leu Thr 
            100                 105                 110         


Asn Val Lys Asp Phe Val Ser Val Cys Trp Glu Tyr Val Arg Pro Tyr 
        115                 120                 125             


Thr Ala Lys Gly Val Ile Ile Cys Ser Ser Cys Leu Phe Gly Arg Glu 
    130                 135                 140                 


Leu Leu Glu Asn Pro Asn Leu Phe Ser Trp Pro Leu Ile Phe Arg Ala 
145                 150                 155                 160 


Leu Leu Gly Met Leu Ala Ile Leu Gly Ser Cys Phe Tyr Thr Ala Gly 
                165                 170                 175     


Ile Asn Gln Ile Phe Asp Met Asp Ile Asp Arg Ile Asn Lys Pro Asp 
            180                 185                 190         


Leu Pro Leu Val Ser Gly Arg Ile Ser Val Glu Ser Ala Trp Leu Leu 
        195                 200                 205             


Thr Leu Ser Pro Ala Ile Ile Gly Phe Ile Leu Ile Leu Lys Leu Asn 
    210                 215                 220                 


Ser Gly Pro Leu Leu Thr Ser Leu Tyr Cys Leu Ala Ile Leu Ser Gly 
225                 230                 235                 240 


Thr Ile Tyr Ser Val Pro Pro Phe Arg Trp Lys Lys Asn Pro Ile Thr 
                245                 250                 255     


Ala Phe Leu Cys Ile Leu Met Ile His Ala Gly Leu Asn Phe Ser Val 
            260                 265                 270         


Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Ala Phe Ala Trp Ser Pro 
        275                 280                 285             


Ser Phe Ser Phe Ile Thr Ala Phe Ile Thr Phe Met Thr Leu Thr Leu 
    290                 295                 300                 


Ala Ser Ser Lys Asp Leu Ser Asp Ile Asn Gly Asp Arg Lys Phe Gly 
305                 310                 315                 320 


Val Glu Thr Phe Ala Thr Lys Leu Gly Ala Lys Asn Ile Thr Leu Leu 
                325                 330                 335     


Gly Thr Gly Leu Leu Leu Leu Asn Tyr Val Ala Ala Ile Ser Thr Ala 
            340                 345                 350         


Ile Ile Trp Pro Lys Ala Phe Lys Ser Asn Ile Met Leu Leu Ser His 
        355                 360                 365             


Ala Ile Leu Ala Phe Ser Leu Ile Phe Gln Ala Arg Glu Leu Asp Arg 
    370                 375                 380                 


Thr Asn Tyr Thr Pro Glu Ala Cys Lys Ser Phe Tyr Glu Phe Ile Trp 
385                 390                 395                 400 


Ile Leu Phe Ser Ala Glu Tyr Val Val Tyr Leu Phe Ile 
                405                 410             


<210>  66
<211>  9444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Steely1

<400>  66
atgaacaaga acagcaagat ccagtcgccc aactcgagcg acgtggcggt gattggcgtc       60

gggtttcggt tccctggtaa ctcgaacgat cctgagtcgc tctggaacaa cctgctggat      120

ggctttgacg ccatcacgca ggtcccgaag gagcggtggg ctacctcctt ccgggagatg      180

ggtctgatca agaacaagtt tggtggcttc ctgaaggact ccgagtggaa gaacttcgac      240

ccgctgtttt ttgggatcgg gcccaaggag gcccccttta ttgaccctca gcagcggctc      300

ctcctctcga tcgtgtggga gtccctggag gatgcgtaca tccgccccga tgagctgcgc      360

ggctcgaaca cgggcgtgtt catcggtgtc agcaacaacg attacacgaa gctgggtttc      420

caggacaact actccatttc cccttacacg atgaccgggt ccaactcctc gctgaacagc      480

aaccgcattt cctactgctt cgatttccgc gggccgtcga ttacggtcga cacggcctgc      540

tccagctccc tcgtctcggt gaacctcggg gtgcagtcca ttcagatggg tgagtgcaag      600

atcgctatct gcgggggtgt gaacgcgctg tttgatccct cgacgtcggt cgccttctcc      660

aagctcggcg tgctgtccga gaacggccgg tgcaactcct ttagcgatca ggcttcgggt      720

tacgtgcgct ccgagggcgc cggtgtcgtc gtgctgaaga gcctcgagca ggccaagctg      780

gacggcgatc ggatttacgg tgtcattaag ggcgtgtcct cgaacgagga cggtgcttcg      840

aacggtgaca agaacagcct caccacgccc agctgcgagg cccagtccat caacatttcc      900

aaggcgatgg agaaggcctc cctgagccct tccgatatct actacatcga ggcccacggg      960

accggcacgc cggtgggcga tcccattgag gtcaaggctc tcagcaagat tttcagcaac     1020

tccaacaaca accagctgaa caacttcagc acggacggga acgacaacga tgacgatgac     1080

gacgacaaca cctcgcccga gccgctgctc atcggttcgt tcaagagcaa catcgggcac     1140

ctcgagtcgg cggctggtat tgcttccctg atcaagtgct gcctgatgct caagaaccgc     1200

atgctggtcc cgtcgatcaa ctgctcgaac ctgaacccgt ccattccctt cgaccagtac     1260

aacattagcg tcatccgcga gattcgccag ttccctaccg acaagctggt gaacattggt     1320

atcaactcgt tcggcttcgg tgggtccaac tgccatctga ttattcagga gtacaacaac     1380

aacttcaaga acaactccac catctgcaac aacaacaaca acaacaacaa caacattgac     1440

tacctgatcc ctatctcctc caagacgaag aagtcgctgg acaagtacct gatcctcatt     1500

aagaccaaca gcaactacca taaggatatc tcgtttgacg attttgtcaa gttccagatc     1560

aagtcgaagc agtacaacct gtcgaaccgg atgaccacga ttgccaacga ttggaacagc     1620

tttattaagg gttcgaacga gttccataac ctgattgagt ccaaggacgg cgagggtggt     1680

agctcgtcct cgaaccgggg tatcgattcc gccaaccaga tcaacaccac caccacgagc     1740

accatcaacg acattgagcc gctcctcgtc ttcgtgtttt gcgggcaggg cccgcagtgg     1800

aacggtatga tcaagaccct gtacaactcg gagaacgtgt tcaagaacac ggtggaccac     1860

gtggattcga ttctgtacaa gtacttcggt tacagcattc tgaacgtgct ctcgaagatt     1920

gacgataacg atgacagcat caaccaccct atcgtcgccc agcccagcct cttcctcctc     1980

cagattggtc tcgtcgagct gtttaagtac tggggcattt acccctccat cagcgtcggc     2040

cattcgttcg gtgaggtctc gtcgtactac ctctcgggga tcatctcgct ggagacggcg     2100

tgcaagatcg tgtacgtgcg gagctcgaac cagaacaaga cgatggggtc cgggaagatg     2160

ctcgtggtct cgatgggttt caagcagtgg aacgaccagt ttagcgcgga gtggtcggac     2220

attgagatcg cttgctacaa cgcccccgac agcatcgtcg tcaccgggaa cgaggagcgc     2280

ctgaaggagc tgtcgatcaa gctctcggac gagtcgaacc agattttcaa cacgtttctg     2340

cgctcgccct gcagcttcca ttccagccac caggaggtca ttaagggctc gatgttcgag     2400

gagctctcca acctgcagag caccggcgag acggagatcc ccctgttcag cacggtgacg     2460

ggtcggcagg tcctctccgg ccacgtcacc gcccagcaca tctacgataa cgtgcgggag     2520

cccgtgctgt ttcagaagac cattgagagc attacctcgt acatcaagtc gcattacccg     2580

tccaaccaga aggtgatcta cgtggagatt gcgcctcatc cgaccctgtt ttcgctcatc     2640

aagaagagca ttccgtcgtc caacaagaac tcgtcgtccg tgctgtgccc tctcaaccgc     2700

aaggagaact ccaacaacag ctacaagaag ttcgtcagcc agctgtactt taacggcgtg     2760

aacgtcgatt ttaactttca gctcaacagc atctgcgata acgtcaacaa cgatcaccac     2820

ctcaacaacg tgaagcagaa ctcgttcaag gagaccacga actccctccc ccggtaccag     2880

tgggagcagg atgagtactg gtcggagcct ctcattagcc ggaagaaccg gctggagggc     2940

cccacgacgt cgctcctggg ccatcggatt atctacagct ttccggtctt tcagtcggtg     3000

ctcgatctgc agtccgataa ctacaagtac ctgctcgatc acctcgtgaa cggtaagccg     3060

gtgtttcctg gggctgggta cctcgacatt atcattgagt ttttcgacta ccagaagcag     3120

cagctcaaca gctcggacag ctcgaactcc tacattatta acgtcgacaa gatccagttt     3180

ctgaacccga tccacctgac ggagaacaag ctccagaccc tgcagtcgag ctttgagcct     3240

attgtcacca agaagtccgc ttttagcgtg aacttcttca ttaaggatac ggtggaggac     3300

cagagcaagg tcaagagcat gtccgacgag acgtggacca acacgtgcaa ggccaccatt     3360

tccctcgagc agcagcagcc ctcgccgtcg tcgaccctga ccctgtccaa gaagcaggat     3420

ctccagattc tgcgcaaccg gtgcgatatc tccaagctcg acaagtttga gctgtacgat     3480

aagatttcga agaacctcgg gctccagtac aacagcctct ttcaggtggt ggacaccatt     3540

gagaccggga aggactgctc cttcgcgacg ctgagcctgc ctgaggatac gctctttacc     3600

acgattctca acccttgcct gctcgacaac tgctttcacg gcctcctcac gctcattaac     3660

gagaagggtt cgttcgtggt ggagagcatt tcctccgtct cgatttacct cgagaacatc     3720

ggttccttta accagaccag cgtggggaac gtgcagtttt acctctacac cacgatttcg     3780

aaggctacgt cctttagcag cgagggcacg tgcaagctgt tcacgaagga tggctccctc     3840

atcctgtcga tcgggaagtt tatcattaag tcgacgaacc cgaagtcgac gaagacgaac     3900

gagacgattg agtcgcccct ggatgagacg ttttcgatcg agtggcagtc gaaggactcg     3960

ccgattccga cccctcagca gattcagcag cagtcccccc tgaactccaa cccgtccttt     4020

atccggagca ccatcctcaa ggacattcag tttgagcagt actgctcctc gattatccat     4080

aaggagctga tcaaccacga gaagtacaag aaccagcagt cgtttgatat taactcgctg     4140

gagaaccacc tcaacgacga ccagctcatg gagtccctct ccatttccaa ggagtacctc     4200

cgctttttca cgcgcattat ctccattatc aagcagtacc ccaagattct caacgagaag     4260

gagctgaagg agctcaagga gatcattgag ctgaagtacc cctcggaggt ccagctgctg     4320

gagtttgagg tcatcgagaa ggtgtcgatg atcattccga agctcctgtt tgagaacgac     4380

aagcagtcgt cgatgacgct ctttcaggac aacctgctga cccggttcta cagcaactcc     4440

aacagcaccc ggttctacct ggagcgggtc tccgagatgg tgctggagag cattcggccc     4500

attgtgcgcg agaagcgggt gttccggatc ctggagatcg gtgctggtac gggctccctc     4560

tccaacgtcg tgctcacgaa gctgaacacc tacctcagca cgctcaactc gaacggtggt     4620

tccggctaca acatcattat cgagtacacg ttcaccgaca tctcggcgaa ctttatcatt     4680

ggtgagatcc aggagaccat gtgcaacctc tacccgaacg tgaccttcaa gttttcggtc     4740

ctggatctcg agaaggagat tattaactcc agcgacttcc tcatgggtga ttacgatatc     4800

gtgctgatgg cttacgtgat ccatgccgtc agcaacatta agttctccat cgagcagctg     4860

tacaagctgc tgtccccgcg gggctggctc ctctgcattg agccgaagtc caacgtggtc     4920

ttttcggatc tggtgtttgg ctgcttcaac cagtggtgga actactacga tgacatccgc     4980

accacccatt gctcgctgag cgagtcgcag tggaaccagc tgctcctcaa ccagtcgctc     5040

aacaacgagt cgtcgtcctc gtccaactgc tacggcggtt tttccaacgt gtccttcatc     5100

ggtggcgaga aggacgtgga ctcccatagc tttattctcc attgccagaa ggagtccatc     5160

tcccagatga agctcgccac caccatcaac aacggcctct cgagcggctc gatcgtcatt     5220

gtgctgaaca gccagcagct cacgaacatg aagtcctacc ccaaggtcat cgagtacatc     5280

caggaggcga cctcgctctg caagaccatt gagatcatcg atagcaagga tgtcctcaac     5340

tccaccaact cggtcctcga gaagatccag aagagcctgc tggtgttctg cctcctgggc     5400

tacgatctgc tggagaacaa ctaccaggag cagtcgttcg agtacgtcaa gctcctcaac     5460

ctgatctcca ccacggccag ctcgagcaac gacaagaagc ctcctaaggt cctcctgatt     5520

accaagcagt cggagcggat tagccggtcg ttttacagcc gctcgctgat cggcatttcc     5580

cggacgagca tgaacgagta cccgaacctc tcgattacct cgatcgatct cgataccaac     5640

gactactcgc tccagtcgct cctcaagccg atttttagca acagcaagtt cagcgataac     5700

gagttcattt tcaagaaggg gctgatgttc gtgtcccgga tttttaagaa caagcagctg     5760

ctcgagtcct cgaacgcctt tgagacggac tcctcgaacc tctactgcaa ggcttcgagc     5820

gatctgagct acaagtacgc tatcaagcag agcatgctca cggagaacca gattgagatt     5880

aaggtggagt gcgtcggtat taacttcaag gacaacctct tctacaaggg gctcctcccc     5940

caggagatct tccggatggg ggacatttac aacccgcctt acggtctgga gtgctccggg     6000

gtgattacgc gcatcggctc gaacgtgacg gagtacagcg tcggtcagaa cgtgtttggt     6060

tttgcgcgcc acagcctcgg ctcgcatgtc gtcacgaaca aggatctggt catcctcaag     6120

cccgacacga tttcgttctc cgaggccgcc tccattcccg tcgtgtactg cacggcctgg     6180

tacagcctct ttaacattgg gcagctgagc aacgaggaga gcattctgat ccatagcgct     6240

accgggggtg tcggcctcgc gtccctcaac ctcctcaaga tgaagaacca gcagcagcag     6300

cctctgacca acgtgtacgc caccgtgggt tccaacgaga agaagaagtt cctgatcgac     6360

aacttcaaca acctgttcaa ggaggacggt gagaacattt tcagcacccg ggataaggag     6420

tacagcaacc agctggagag caagattgat gtcatcctga acacgctgtc cggcgagttc     6480

gtcgagagca actttaagtc gctgcgctcc tttgggcggc tcatcgacct cagcgctacc     6540

cacgtgtacg cgaaccagca gattggtctc ggtaacttta agtttgacca cctctactcg     6600

gccgtcgacc tggagcggct cattgatgag aagcccaagc tcctgcagtc catcctccag     6660

cggatcacga actcgattgt gaacgggagc ctggagaaga tccccatcac cattttcccg     6720

tcgaccgaga ccaaggacgc gatcgagctg ctctcgaagc gcagccatat cggcaaggtg     6780

gtggtcgatt gcaccgacat cagcaagtgc aaccctgtgg gcgacgtgat caccaacttc     6840

tccatgcggc tgccgaagcc taactaccag ctgaacctga acagcaccct gctgatcacg     6900

ggccagtcgg ggctgtcgat tcccctgctc aactggctgc tgtcgaagag cggtggcaac     6960

gtgaagaacg tggtgatcat cagcaagagc accatgaagt ggaagctgca gacgatgatt     7020

tcgcattttg tgtcgggttt tggcatccat tttaactacg tgcaggtgga catttccaac     7080

tacgatgccc tctccgaggc gatcaagcag ctgccgagcg acctcccgcc cattacctcg     7140

gtgttccatc tggccgctat ctacaacgat gtccccatgg atcaggtgac gatgtcgacg     7200

gtggagtccg tgcacaaccc taaggtgctc ggcgctgtca acctccaccg gatctccgtc     7260

agcttcgggt ggaagctgaa ccacttcgtc ctcttttcgt ccattacggc tatcacgggt     7320

tacccggatc agtcgattta caacagcgcc aactccatcc tggacgctct ctccaacttc     7380

cggcggttca tgggtctccc tagcttcagc attaacctgg ggccgatgaa ggatgagggc     7440

aaggtgagca ccaacaagag cattaagaag ctgttcaagt cccggggtct gccttcgctg     7500

agcctgaaca agctgttcgg cctgctggag gtcgtgatca acaacccgag caaccatgtg     7560

atcccctcgc agctgatctg ctcgcctatc gactttaaga cgtacatcga gtccttttcg     7620

accatgcgcc cgaagctcct ccacctccag cccaccatct ccaagcagca gtcctcgatc     7680

atcaacgact ccaccaaggc gtcgtcgaac atttcgctgc aggacaagat taccagcaag     7740

gtcagcgacc tgctcagcat tcccatcagc aagattaact ttgatcatcc gctcaagcat     7800

tacgggctgg attccctgct caccgtccag ttcaagtcct ggatcgacaa ggagtttgag     7860

aagaacctgt ttacccatat ccagctggcg acgattagca tcaactcgtt tctcgagaag     7920

gtcaacggtc tgtcgaccaa caacaacaac aacaacaaca gcaacgtgaa gtccagcccg     7980

agcattgtga aggaggagat tgtcacgctg gacaaggacc agcagcccct cctgctcaag     8040

gagcaccagc atattatcat tagccccgac attcgcatca acaagcctaa gcgcgagtcc     8100

ctgattcgca cgcccattct gaacaagttt aaccagatca ccgagtcgat catcaccccc     8160

tcgacgcctt ccctcagcca gagcgacgtg ctgaagacgc cgcctattaa gtcgctcaac     8220

aacacgaaga actccagcct catcaacacc cctccgattc agtccgtcca gcagcatcag     8280

aagcagcagc agaaggtgca ggtcattcag cagcagcagc agccgctcag ccggctgtcc     8340

tacaagtcca acaacaacag ctttgtcctg ggcatcggga tctccgtccc cggcgagccc     8400

attagccagc agtccctgaa ggattccatt agcaacgatt tctcggacaa ggctgagacc     8460

aacgagaagg tgaagcgcat tttcgagcag tcgcagatca agacgcgcca tctcgtgcgg     8520

gattacacga agcctgagaa ctcgattaag tttcgccatc tggagaccat caccgacgtg     8580

aacaaccagt tcaagaaggt cgtcccggat ctcgctcagc aggcctgcct ccgggcgctg     8640

aaggattggg ggggggataa gggggatatt acccacattg tgtcggtgac gagcaccggt     8700

attatcatcc ctgacgtgaa ctttaagctc atcgatctcc tcggtctcaa caaggacgtg     8760

gagcgcgtct cgctcaacct catgggctgc ctcgctggcc tctccagcct ccgcacggct     8820

gcgtcgctcg cgaaggcgtc gccccggaac cggatcctcg tggtctgcac ggaggtgtgc     8880

agcctccatt tctcgaacac cgatggcggt gaccagatgg tcgcgtcgag catctttgcc     8940

gacgggtcgg ccgcctacat cattggctgc aacccgcgga ttgaggagac cccgctgtac     9000

gaggtgatgt gctcgatcaa ccggtcgttt ccgaacacgg agaacgcgat ggtctgggac     9060

ctggagaagg agggctggaa cctcggcctg gatgcgtcga ttcccatcgt catcggctcg     9120

gggatcgagg ccttcgtcga taccctcctg gacaaggcga agctccagac gtcgaccgcc     9180

atttcggcta aggactgcga gtttctcatc catacgggcg gtaagtcgat tctcatgaac     9240

attgagaact cgctgggcat cgatcccaag cagacgaaga acacctggga cgtgtaccac     9300

gcctacggca acatgagcag cgccagcgtg atttttgtca tggaccacgc tcgcaagtcg     9360

aagtcgctcc cgacgtactc catcagcctc gccttcggtc ctgggctcgc gttcgagggg     9420

tgcttcctca agaacgtcgt ctaa                                            9444


<210>  67
<211>  8907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Steely2

<400>  67
atgaacaaca acaagagcat caacgatctc agcggtaact ccaacaacaa catcgctaac       60

agcaacatta acaactacaa caacctgatt aagaaggagc ctattgctat cattggcatc      120

gggtgccgct tccctgggaa cgtgtccaac tactcggact tcgtgaacat cattaagaac      180

ggctccgact gcctcaccaa gattcctgac gaccgctgga acgctgacat catttcgcgg      240

aagcagtgga agctgaacaa ccgcatcggg ggttacctga agaacatcga ccagttcgac      300

aaccagtttt tcggcatttc gcctaaggag gctcagcata tcgatcctca gcagcggctg      360

ctcctgcacc tcgctatcga gaccctggag gatggcaaga tctccctgga tgagatcaag      420

ggtaagaagg tgggcgtgtt catcgggtcc agctccggcg attacctgcg ggggtttgat      480

tcgagcgaga tcaaccagtt taccacgccg gggaccaact ccagcttcct gtcgaaccgg      540

ctctcgtact ttctcgacgt gaacgggccc tccatgacgg tgaacaccgc gtgctcggct      600

agcatggtgg cgattcatct ggggctccag tcgctgtgga acggcgagtc ggagctcagc      660

atggtgggcg gtgtgaacat tatttcctcg ccgctccagt cgctggactt cgggaaggcg      720

gggctgctca accaggagac ggatggccgg tgctacagct ttgatccccg cgcttccggg      780

tacgtccgct cggagggtgg cggcatcctc ctcctcaagc ctctgtcggc ggctctgcgg      840

gacaacgatg agatctactc cctcctgctg aactccgcga acaactcgaa cgggaagacg      900

cccacgggta tcacctcccc gcgctccctc tgccaggaga agctcattca gcagctcctg      960

cgcgagagct cggaccagtt ctcgattgac gatattggtt actttgagtg ccacggcacg     1020

ggcacccaga tgggggacct caacgagatt acggcgatcg gcaagtcgat tgggatgctg     1080

aagtcgcacg acgaccctct cattatcggc tccgtcaagg cgtcgattgg gcatctcgag     1140

ggtgcgagcg gcatttgcgg tgtgatcaag tcgattatct gcctcaagga gaagatcctg     1200

ccgcagcagt gcaagtttag ctcctacaac cccaagattc cttttgagac cctgaacctg     1260

aaggtcctca ccaagacgca gccgtggaac aactcgaagc ggatttgcgg cgtcaactcg     1320

tttggggtcg gcggtagcaa ctccagcctg ttcctgagct cgtttgataa gagcacgacc     1380

atcacggagc ccaccaccac gaccaccatc gagtccctgc cctccagctc gtcctcgttc     1440

gacaacctga gcgtgtcctc ctccatttcg accaacaacg acaacgataa ggtcagcaac     1500

atcgtgaaca accgctacgg cagctccatt gacgtcatca cgctgtcggt gacgtcgccg     1560

gataaggagg acctgaagat tcgggcgaac gatgtcctcg agtcgatcaa gacgctcgat     1620

gataacttca agattcgcga tatcagcaac ctgacgaaca ttcgcacctc ccacttctcc     1680

aaccgcgtcg ctattatcgg tgactcgatc gactccatta agctcaacct gcagtccttt     1740

atcaaggggg agaacaacaa caacaagtcg attatcctgc ctctgattaa caacggcaac     1800

aacaacaaca acaacaacaa caactcgtcc gggtcctcgt cctccagcag caacaacaac     1860

aacatttgct tcatctttag cggccagggc cagcagtgga acaagatgat cttcgatctg     1920

tacgagaaca acaagacctt caagaacgag atgaacaact tttccaagca gttcgagatg     1980

atttcgggct ggtcgatcat tgacaagctg tacaactccg gcggtggtgg taacgaggag     2040

ctcattaacg agacgtggct cgcccagccg tccattgtgg ccgtccagta ctcgctgatt     2100

aagctgttta gcaaggacat cgggatcgag gggtcgatcg tcctcgggca cagcctgggt     2160

gagctcatgg ctgcttacta ctgcggtatc attaacgact ttaacgatct gctgaagctg     2220

ctctacatcc ggtcgacgct ccagaacaag acgaacgggt cgggtcgcat gcacgtgtgc     2280

ctcagcagca aggccgagat cgagcagctg atttcgcagc tcgggtttaa cggccggatt     2340

gtgatttgcg ggaacaacac gatgaagtcg tgcaccatct cgggtgataa cgagtcgatg     2400

aaccagttta ccaagctcat ttcgtcgcag cagtacggca gcgtcgtgca taaggaggtc     2460

cgcacgaaca gcgcctttca ttcgcaccag atggacatca tcaaggacga gttctttaag     2520

ctctttaacc agtacttccc tacgaaccag attagcacca accagattta cgatggcaag     2580

agcttctact cgacgtgcta cgggaagtac ctgacgccta ttgagtgcaa gcagctcctc     2640

tcgtcgccga actactggtg gaagaacatt cgcgagtcgg tgctctttaa ggagtcgatt     2700

gagcagatcc tgcagaacca ccagcagtcg ctcacgttta ttgagatcac gtgccaccct     2760

atcctcaact acttcctgtc gcagctcctg aagtcgagca gcaagtcgaa caccctcctg     2820

ctctccacgc tgtcgaagaa cagcaactcc atcgatcagc tgctcattct gtgcagcaag     2880

ctgtacgtca acaacctctc ctcgatcaag tggaactggt tttacgacaa gcagcagcag     2940

cagcagtcgg agtcgctcgt gagcagcaac tttaagctgc ctggccgccg gtggaagctc     3000

gagaagtact ggatcgagaa ctgccagcgc cagatggatc ggattaagcc gccgatgttc     3060

attagcctcg atcggaagct gttttccgtc acgccgtcct ttgaggtgcg gctcaaccag     3120

gatcgcttcc agtacctgaa cgaccaccag attcaggata tccccctggt gccgttctcc     3180

ttttacatcg agctcgtgta cgcctccatc tttaactcca tctccaccac caccacgaac     3240

acgacggctt cgaccatgtt tgagatcgag aacttcacca ttgatagcag catcatcatc     3300

gaccagaaga agtcgaccct catcggtatt aacttcaact cggacctcac gaagtttgag     3360

atcggctcca ttaactccat cgggtcgggt tcgtcgtcga acaacaactt tatcgagaac     3420

aagtggaaga tccattcgaa cggtattatt aagtacggta ccaactacct caagagcaac     3480

agcaagtcca acagcttcaa cgagtcgacg acgacgacca cgacgaccac caccaccacc     3540

aagtgcttca agagcttcaa cagcaacgag ttttacaacg agattattaa gtacaactac     3600

aactacaagt cgacgttcca gtgcgtcaag gagttcaagc agttcgacaa gcaggggacg     3660

ttctactact ccgagattca gttcaagaag aacgataagc aggtcattga tcagctcctc     3720

tcgaagcagc tgccttccga ctttcgctgc atccaccctt gcctgctgga cgccgtgctc     3780

cagagcgcta ttattcctgc gacgaacaag accaactgct cgtggattcc tatcaagatc     3840

gggaagctca gcgtcaacat tccctcgaac tcctacttca actttaagga tcagctcctc     3900

tactgcctca ttaagccgtc cacctccacc tcgacctccc ctagcacgta cttttcgtcg     3960

gacatccagg tgttcgataa gaagaacaac aacctgatct gcgagctgac gaacctggag     4020

ttcaagggga ttaacagcag ctcctcgagc agctcgtcgt cgtccacgat taactcgaac     4080

gtggaggcca actacgagtc caagatcgag gagaccaacc acgatgagga tgaggacgag     4140

gagctccccc tcgtgagcga gtacgtgtgg tgcaaggagg agctgattaa ccagagcatc     4200

aagttcaccg ataactacca gaccgtgatt ttttgcagca cgaacctgaa cggtaacgat     4260

ctgctggact ccatcatcac cagcgccctg gagaacgggc acgacgagaa caagattttc     4320

attgtctccc cgccccccgt cgagtcggac cagtacaaca accggattat tattaactac     4380

acgaacaacg agagcgactt cgatgctctg tttgccatca tcaactccac gacgtccatc     4440

agcggcaaga gcggcctgtt ttccacgcgg tttattattc tgcctaactt taactccatt     4500

acgttctcct ccggcaactc cacgcccctg atcaccaacg tgaacggtaa cggcaacggg     4560

aagtcgtgcg gcgggggcgg tggttccacc aacaacacca tctccaactc gtcgtcgagc     4620

atttcgtcca tcgataacgg caacaacgag gatgaggaga tggtcctcaa gagctttaac     4680

gatagcaacc tcagcctgtt tcacctccag aagagcatca ttaagaacaa cattaagggc     4740

cgcctgtttc tgattacgaa cggggggcag agcatcagct cgtccacgcc gacctccacc     4800

tacaacgacc agtcctacgt gaacctcagc cagtaccagc tgattggcca gatccgcgtg     4860

tttagcaacg agtacccgat tatggagtgc tcgatgatcg acatccagga ttcgacgcgg     4920

attgacctca ttaccgatca gctcaacagc accaagctca gcaagctcga gatcgcgttc     4980

cgggataaca ttggctacag ctacaagctg ctgaagccct ccatttttga caactcgtcg     5040

ctgccgagct cgtcgtccga gatcgagacg accgctacca cgaaggatga ggagaagaac     5100

aactccatta actacaacaa caactactac cgggtcgagc tctccgacaa cgggattatt     5160

agcgatctca agatcaagca gttccgccag atgaagtgcg gggtgggcca ggtgctggtg     5220

cgcgtcgaga tgtgcacgct caacttccgg gacatcctca agtcgctcgg tcgcgattac     5280

gaccctatcc acctgaactc gatgggtgac gagttctcgg gtaaggtgat tgagattggc     5340

gagggggtga acaacctgag cgtcggccag tacgtgttcg gtattaacat gtccaagtcc     5400

atgggcagct ttgtgtgctg caacagcgac ctcgtctttc ctattcccat tccgacccct     5460

tccagcagca gctcgagcaa cgagaacatc gatgaccagg agatcatttc gaagctgctg     5520

aaccagtact gcacgattcc gattgtcttt ctcacgtcct ggtacagcat cgtcattcag     5580

ggccgcctga agaagggtga gaagattctg atccactccg gttgcggggg tgtgggtctg     5640

gctaccattc agatttcgat gatgattggc gcggagatcc acgtgacggt ggggagcaac     5700

gagaagaagc agtacctgat caaggagttc ggtattgacg agaagcggat ttacagctcg     5760

cgctccctcc agttttacaa cgacctgatg gtcaacaccg acggtcaggg tgtcgatatg     5820

gtgctgaact ccctgagcgg tgagtacctc gagaagtcca tccagtgcct gtcccagtac     5880

ggccggttta ttgagattgg caagaaggat atctactcga actccagcat tcacctggag     5940

ccttttaaga acaacctgag ctttttcgct gtggacattg cgcagatgac ggagaaccgg     6000

cgggactacc tgcgcgagat catgatcgat cagctgctgc cttgcttcaa gaacgggtcc     6060

ctcaagcctc tcaaccagca ctgcttcaac tccccctgcg acctcgtgaa ggctatccgg     6120

tttatgtcgt cggggaacca tattggtaag atcctcatca actggagcaa cctcaacaac     6180

gacaagcagt tcatcaacca ccattcggtc gtccatctcc ctatccagtc gttttcgaac     6240

cgcagcacgt acatttttac cggcttcggt gggctcaccc agacgctcct gaagtacttt     6300

agcaccgagt ccgacctgac caacgtgatc attgtctcga agaacggcct ggatgacaac     6360

tcgggtagcg gtagcgggaa caacgagaag ctcaagctga tcaaccagct gaaggagtcc     6420

gggctcaacg tgctcgtcga gaagtgcgat ctgagctcca ttaagcaggt ctacaagctc     6480

ttcaacaaga ttttcgacaa cgatgcttcg ggctccgatt cgggcgattt ctcggacatc     6540

aagggtattt ttcacttcgc gtccctgatt aacgacaagc gcatcctgaa gcacaacctg     6600

gagtccttta actacgtcta caactccaag gcgacgagcg cctggaacct ccatcaggtc     6660

tcgctgaagt acaacctcaa cctcgaccat tttcagacga tcggcagcgt catcaccatt     6720

ctggggaaca tcggccagag caactacacg tgcgccaacc gctttgtcga gggtctcacg     6780

catctccgca ttggcatggg cctgaagagc tcctgcattc atctcgctag cattcctgat     6840

gtgggtatgg cgagcaacga caacgtgctg aacgacctca actccatggg gttcgtgccc     6900

ttccagagcc tgaacgagat gaacctgggg tttaagaagc tcctctcctc gccgaacccg     6960

atcgtggtcc tcggcgagat taacgtggat cgctttattg aggcgacccc caacttccgg     7020

gctaaggata actttattat tacgtcgctg tttaaccgga ttgaccccct gctgctggtc     7080

aacgagagcc aggattttat tattaacaac aacatcaaca acaacggcgg gggtggtgac     7140

gggagcttcg atgacctgaa ccagctcgag gatgagggtc agcagggttt cggcaacggg     7200

gacggttacg tcgacgataa cattgactcg gtgtcgatgc tcagcggcac ctccagcatt     7260

tttgataacg atttctacac gaagtcgatc cggggtatgc tctgcgacat tctcgagctc     7320

aaggacaagg atctgaacaa cacggtgtcg ttcagcgact acggcctgga ctccctgctc     7380

tcgagcgagc tcagcaacac catccagaag aacttctcca ttctgatccc ctccctgacc     7440

ctggtggaca actcgacgat caactccacc gtcgagctca ttaagaacaa gctcaagaac     7500

tccacgacca gctcgatctc ctcctcggtg agcaagaagg tctcctttaa gaagaacacc     7560

cagcccctga tcatccctac gacggctccg attagcatta tcaagacgca gtcgtacatt     7620

aagtcggaga tcattgagag cctccccatt agctccagca ccacgatcaa gcctctcgtc     7680

ttcgataacc tcgtctactc cagctcgagc agcaacaaca gcaactccaa gaacgagctc     7740

acgtcgccgc ccccgagcgc caagcgcgag agcgtgctgc ccatcatcag cgaggataac     7800

aacagcgata acgatagcag catggccacc gtgatttacg agatctcccc gattgccgcg     7860

ccttaccatc gctaccagac ggatgtcctc aaggagatca cccagctgac gccccacaag     7920

gagttcattg acaacatcta caagaagtcg aagattcgca gccgctactg ctttaacgat     7980

ttctccgaga agtcgatggc ggatatcaac aagctggacg ctggtgagcg cgtcgcgctc     8040

ttccgggagc agacgtacca gaccgtgatt aacgccggga agaccgtgat cgagcgcgct     8100

gggattgatc cgatgctcat ctcccatgtg gtgggggtga cgtcgaccgg tattatggct     8160

ccttcctttg atgtcgtgct cattgataag ctgggcctgt cgattaacac ctcccggacc     8220

atgattaact ttatgggctg cggggctgcg gtcaacagca tgcgggccgc caccgcttac     8280

gctaagctca agcccggtac gttcgtcctg gtggtggccg tcgaggccag cgctacctgc     8340

atgaagttca acttcgactc gcggtcggat ctgctgtccc aggccatttt cacggatggg     8400

tgcgtcgcca ccctggtcac ctgccagcct aagtcctcgc tggtcggcaa gctggagatt     8460

atcgatgacc tgtcctacct catgcctgac agccgcgatg cgctcaacct ctttattggg     8520

cctacgggga tcgacctcga cctgcggccc gagctcccta ttgcgattaa ccggcatatc     8580

aactccgcga tcacgtcgtg gctgaagaag aacagcctgc agaagtcgga catcgagttt     8640

tttgcgaccc atcctggcgg cgctaagatc atttcggccg tccacgaggg gctcggtctg     8700

tcgcctgagg acctcagcga ctcctacgag gtcatgaagc ggtacggcaa catgatcggt     8760

gtctcgacgt actacgtcct gcggcgcatc ctcgacaaga accagacgct cctccaggag     8820

gggtcgctcg gctacaacta cggcatggct atggctttca gccctggggc gtcgatcgag     8880

gccattctgt ttaagctgat taagtaa                                         8907


<210>  68
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Orf2

<400>  68
atgagcgagg cggccgatgt cgagcgggtc tacgctgcta tggaggaggc tgctgggctg       60

ctgggcgtgg cgtgcgcgcg cgataagatc taccccctcc tcagcacctt tcaggatacc      120

ctggtggagg gtggtagcgt ggtggtcttc agcatggctt ccgggcggca ttccaccgag      180

ctcgattttt ccatctcggt ccccacgtcc cacggggacc cttacgcgac cgtcgtggag      240

aagggtctct tccccgctac gggtcacccc gtggatgatc tgctggccga tacgcagaag      300

catctgccgg tgagcatgtt cgctatcgac ggggaggtca ccggcggctt taagaagacg      360

tacgccttct ttcctaccga taacatgcct ggggtggccg agctcagcgc cattccttcg      420

atgccgcccg ccgtggccga gaacgctgag ctgtttgcgc ggtacggcct ggataaggtg      480

cagatgacct ccatggatta caagaagcgc caggtgaacc tctacttttc ggagctctcc      540

gctcagaccc tcgaggccga gtccgtcctg gctctcgtgc gggagctggg tctccatgtc      600

ccgaacgagc tcgggctcaa gttctgcaag cgctcgttct cggtctaccc taccctcaac      660

tgggagaccg gcaagattga ccgcctgtgc ttcgctgtga ttagcaacga tcctaccctc      720

gtccctagct ccgatgaggg tgacatcgag aagttccaca actacgctac caaggcgccc      780

tacgcttacg tgggggagaa gcgcacgctg gtctacggcc tcaccctgag ccctaaggag      840

gagtactaca agctcggcgc ttactaccac atcacggatg tccagcgcgg cctcctcaag      900

gcctttgact cgctggagga ttga                                             924


<210>  69
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized CsPT4

<400>  69
atggggctct cgctcgtctg cacctttagc tttcagacca actaccatac gctgctgaac       60

ccgcacaaca agaacccgaa gaacagcctc ctcagctacc agcaccccaa gacccccatt      120

atcaagtcca gctacgataa ctttcctagc aagtactgcc tcaccaagaa cttccacctg      180

ctcggcctca acagccataa ccgcatttcc agccagtccc gctccatccg cgctggctcc      240

gatcagatcg aggggtcccc gcatcacgag tccgacaact cgatcgccac caagattctg      300

aactttgggc acacgtgctg gaagctgcag cggccgtacg tcgtcaaggg gatgatctcg      360

atcgcctgcg ggctgttcgg tcgggagctc ttcaacaacc ggcatctgtt tagctggggc      420

ctgatgtgga aggctttttt cgcgctggtg cccatcctca gcttcaactt ttttgccgct      480

atcatgaacc agatttacga tgtggacatt gaccggatta acaagcccga cctgcccctg      540

gtcagcggtg agatgtccat tgagaccgct tggattctca gcattatcgt ggcgctcacg      600

ggcctgatcg tcaccatcaa gctcaagagc gctccgctct ttgtgttcat ctacatcttt      660

ggcatttttg cgggtttcgc ttacagcgtg cctccgatcc gctggaagca gtacccgttc      720

acgaactttc tgattacgat tagctcgcat gtgggtctcg cttttacgtc gtacagcgct      780

accacctcgg ctctcggcct gccttttgtc tggcgccccg cgttctcctt tatcattgcg      840

ttcatgaccg tcatgggcat gacgattgcg tttgctaagg atatttccga tatcgagggt      900

gatgccaagt acggcgtcag cacggtcgcc acgaagctgg gggcgcggaa catgacgttt      960

gtcgtgtcgg gcgtgctcct cctcaactac ctcgtctcga tctcgatcgg gatcatctgg     1020

cctcaggtct ttaagagcaa cattatgatt ctgtcccatg ccattctggc cttttgcctg     1080

atctttcaga cgcgcgagct cgccctcgcg aactacgcta gcgctccttc ccgccagttc     1140

ttcgagttta tctggctcct ctactacgcg gagtactttg tgtacgtgtt catttaa        1197


<210>  70
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized HlPT1

<400>  70
atggagctgt cgtcggtcag ctcgttctcc ctgggtacca acccttttat ctccatcccg       60

cacaacaaca acaacctcaa ggtgtcgtcc tactgctgca agtccaagtc gcgggtcatc      120

aactcgacca actcgaagca ctgcagcccc aacaacaaca gcaacaacaa cacctcgaac      180

aagacgacgc atctgctcgg cctgtacggg cagtcccggt gcctcctgaa gcctctcagc      240

tttatttcgt gcaacgatca gcgcggtaac tcgattcggg cgtccgctca gattgaggat      300

cggccccccg agtcgggtaa cctctccgcg ctgaccaacg tcaaggactt tgtgtccgtg      360

tgctgggagt acgtgcggcc ttacaccgcc aagggcgtca ttatctgctc ctcctgcctc      420

ttcggccggg agctgctgga gaaccccaac ctctttagct ggcctctcat ttttcgcgcc      480

ctcctcggca tgctggccat tctgggtagc tgcttctaca cggctggcat caaccagatt      540

ttcgacatgg acatcgaccg gattaacaag cctgatctgc cgctcgtctc ggggcggatt      600

tcggtggaga gcgcttggct cctgaccctc agccctgcga ttattggttt tatcctgatc      660

ctgaagctga actccgggcc tctcctgacc agcctgtact gcctcgcgat tctcagcggg      720

accatttaca gcgtccctcc ctttcggtgg aagaagaacc cgatcacggc ttttctctgc      780

atcctgatga ttcacgctgg gctcaacttc tccgtgtact acgcgtcccg ggctgccctc      840

ggtctggctt ttgcgtggtc gccgagcttc tccttcatca ccgccttcat tacctttatg      900

acgctgaccc tggcttccag caaggatctc agcgatatta acggcgaccg gaagttcggc      960

gtggagacct ttgctacgaa gctgggcgcg aagaacatca ccctcctggg gaccgggctc     1020

ctgctcctca actacgtcgc cgctatcagc acggccatta tttggccgaa ggcgtttaag     1080

tcgaacatca tgctcctgtc gcatgcgatc ctggcctttt ccctgatttt tcaggcgcgc     1140

gagctcgacc gcacgaacta cacgccggag gcctgcaagt ccttctacga gttcatttgg     1200

atcctctttt cggctgagta cgtggtgtac ctctttatt                            1239


