                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Vance, Russell
       Mitchell, Patrick
       Sandstrom, Andrew
 
<120>  Degradation-Activated Polypeptides and Methods of Using the Same

<130>  BERK-385PRV2

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1473
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1265                 1270                 1275             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1295                 1300                 1305             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1310                 1315                 1320             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1325                 1330                 1335             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1340                 1345                 1350             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1355                 1360                 1365             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1370                 1375                 1380             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1385                 1390                 1395             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1400                 1405                 1410             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1415                 1420                 1425             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1430                 1435                 1440             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1445                 1450                 1455             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1460                 1465                 1470             


<210>  2
<211>  1375
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Gly  Lys Ser His Glu Glu  Ser Ser Pro 
    1040                 1045                 1050             


Glu Val  Val Pro Val Glu Leu  Leu Cys Val Pro Ser  Pro Ala Ser 
    1055                 1060                 1065             


Gln Gly  Asp Leu His Thr Lys  Pro Leu Gly Thr Asp  Asp Asp Phe 
    1070                 1075                 1080             


Trp Gly  Pro Thr Gly Pro Val  Ala Thr Glu Val Val  Asp Lys Glu 
    1085                 1090                 1095             


Lys Asn  Leu Tyr Arg Val His  Phe Pro Val Ala Gly  Ser Tyr Arg 
    1100                 1105                 1110             


Trp Pro  Asn Thr Gly Leu Cys  Phe Val Met Arg Glu  Ala Val Thr 
    1115                 1120                 1125             


Val Glu  Ile Glu Phe Cys Val  Trp Asp Gln Phe Leu  Gly Glu Ile 
    1130                 1135                 1140             


Asn Pro  Gln His Ser Trp Met  Val Ala Gly Pro Leu  Leu Asp Ile 
    1145                 1150                 1155             


Lys Ala  Glu Pro Gly Ala Val  Glu Ala Val His Leu  Pro His Phe 
    1160                 1165                 1170             


Val Ala  Leu Gln Gly Gly His  Val Asp Thr Ser Leu  Phe Gln Met 
    1175                 1180                 1185             


Ala His  Phe Lys Glu Glu Gly  Met Leu Leu Glu Lys  Pro Ala Arg 
    1190                 1195                 1200             


Val Glu  Leu His His Ile Val  Leu Glu Asn Pro Ser  Phe Ser Pro 
    1205                 1210                 1215             


Leu Gly  Val Leu Leu Lys Met  Ile His Asn Ala Leu  Arg Phe Ile 
    1220                 1225                 1230             


Pro Val  Thr Ser Val Val Leu  Leu Tyr His Arg Val  His Pro Glu 
    1235                 1240                 1245             


Glu Val  Thr Phe His Leu Tyr  Leu Ile Pro Ser Asp  Cys Ser Ile 
    1250                 1255                 1260             


Arg Lys  Ala Ile Asp Asp Leu  Glu Met Lys Phe Gln  Phe Val Arg 
    1265                 1270                 1275             


Ile His  Lys Pro Pro Pro Leu  Thr Pro Leu Tyr Met  Gly Cys Arg 
    1280                 1285                 1290             


Tyr Thr  Val Ser Gly Ser Gly  Ser Gly Met Leu Glu  Ile Leu Pro 
    1295                 1300                 1305             


Lys Glu  Leu Glu Leu Cys Tyr  Arg Ser Pro Gly Glu  Asp Gln Leu 
    1310                 1315                 1320             


Phe Ser  Glu Phe Tyr Val Gly  His Leu Gly Ser Gly  Ile Arg Leu 
    1325                 1330                 1335             


Gln Val  Lys Asp Lys Lys Asp  Glu Thr Leu Val Trp  Glu Ala Leu 
    1340                 1345                 1350             


Val Lys  Pro Gly Arg Asn Thr  Ser Gln Pro Trp Asn  Leu Arg Cys 
    1355                 1360                 1365             


Asn Arg  Asp Ala Arg Arg Tyr  
    1370                 1375 


<210>  3
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  4
<211>  1473
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1265                 1270                 1275             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1295                 1300                 1305             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1310                 1315                 1320             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1325                 1330                 1335             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1340                 1345                 1350             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1355                 1360                 1365             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1370                 1375                 1380             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1385                 1390                 1395             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1400                 1405                 1410             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1415                 1420                 1425             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1430                 1435                 1440             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1445                 1450                 1455             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1460                 1465                 1470             


<210>  5
<211>  1443
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser 
945                 950                 955                 960 


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
                965                 970                 975     


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
            980                 985                 990         


His Val Ala Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
        995                 1000                 1005             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1010                 1015                 1020             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1025                 1030                 1035             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1040                 1045                 1050             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1055                 1060                 1065             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1070                 1075                 1080             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1085                 1090                 1095             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1100                 1105                 1110             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1115                 1120                 1125             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1130                 1135                 1140             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1145                 1150                 1155             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1160                 1165                 1170             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1175                 1180                 1185             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1190                 1195                 1200             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1205                 1210                 1215             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1220                 1225                 1230             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1235                 1240                 1245             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1250                 1255                 1260             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1265                 1270                 1275             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1280                 1285                 1290             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1295                 1300                 1305             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1310                 1315                 1320             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1325                 1330                 1335             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1340                 1345                 1350             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1355                 1360                 1365             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1370                 1375                 1380             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1385                 1390                 1395             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1400                 1405                 1410             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1415                 1420                 1425             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1430                 1435                 1440             


<210>  6
<211>  1399
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser 
945                 950                 955                 960 


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
                965                 970                 975     


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
            980                 985                 990         


His Val Ala Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
        995                 1000                 1005             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1010                 1015                 1020             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1025                 1030                 1035             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1040                 1045                 1050             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1055                 1060                 1065             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1070                 1075                 1080             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1085                 1090                 1095             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1100                 1105                 1110             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1115                 1120                 1125             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1130                 1135                 1140             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1145                 1150                 1155             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1160                 1165                 1170             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1175                 1180                 1185             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1190                 1195                 1200             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1205                 1210                 1215             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1220                 1225                 1230             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1235                 1240                 1245             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1250                 1255                 1260             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1265                 1270                 1275             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1280                 1285                 1290             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1295                 1300                 1305             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1310                 1315                 1320             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1325                 1330                 1335             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1340                 1345                 1350             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1355                 1360                 1365             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1370                 1375                 1380             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1385                 1390                 1395             


Ser 
    


<210>  7
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Met Arg Gln Arg Gln Ser His Tyr Cys Ser Val Leu Phe Leu Ser 
1               5                   10                  15      


Val Asn Tyr Leu Gly Gly Thr Phe Pro Gly Asp Ile Cys Ser Glu Glu 
            20                  25                  30          


Asn Gln Ile Val Ser Ser Tyr Ala Ser Lys Val Cys Phe Glu Ile Glu 
        35                  40                  45              


Glu Asp Tyr Lys Asn Arg Gln Phe Leu Gly Pro Glu Gly Asn Val Asp 
    50                  55                  60                  


Val Glu Leu Ile Asp Lys Ser Thr Asn Arg Tyr Ser Val Trp Phe Pro 
65                  70                  75                  80  


Thr Ala Gly Trp Tyr Leu Trp Ser Ala Thr Gly Leu Gly Phe Leu Val 
                85                  90                  95      


Arg Asp Glu Val Thr Val Thr Ile Ala Phe Gly Ser Trp Ser Gln His 
            100                 105                 110         


Leu Ala Leu Asp Leu Gln His His Glu Gln Trp Leu Val Gly Gly Pro 
        115                 120                 125             


Leu Phe Asp Val Thr Ala Glu Pro Glu Glu Ala Val Ala Glu Ile His 
    130                 135                 140                 


Leu Pro His Phe Ile Ser Leu Gln Gly Glu Val Asp Val Ser Trp Phe 
145                 150                 155                 160 


Leu Val Ala His Phe Lys Asn Glu Gly Met Val Leu Glu His Pro Ala 
                165                 170                 175     


Arg Val Glu Pro Phe Tyr Ala Val Leu Glu Ser Pro Ser Phe Ser Leu 
            180                 185                 190         


Met Gly Ile Leu Leu Arg Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro 
        195                 200                 205             


Ile Thr Ser Asn Thr Leu Ile Tyr Tyr His Pro His Pro Glu Asp Ile 
    210                 215                 220                 


Lys Phe His Leu Tyr Leu Val Pro Ser Asp Ala Leu Leu Thr Lys Ala 
225                 230                 235                 240 


Ile Asp Asp Glu Glu Asp Arg Phe His Gly Val Arg Leu Gln Thr Ser 
                245                 250                 255     


Pro Pro Met Glu Pro Leu Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn 
            260                 265                 270         


Ser Ala Asn Leu Lys Val Met Pro Lys Glu Leu Lys Leu Ser Tyr Arg 
        275                 280                 285             


Ser Pro Gly Glu Ile Gln His Phe Ser Lys Phe Tyr Ala Gly Gln Met 
    290                 295                 300                 


Lys Glu Pro Ile Gln Leu Glu Ile Thr Glu Lys Arg His Gly Thr Leu 
305                 310                 315                 320 


Val Trp Asp Thr Glu Val Lys Pro Val Asp Leu Gln Leu Val Ala Ala 
                325                 330                 335     


Ser Ala Pro Pro Pro Phe Ser Gly Ala Ala Phe Val Lys Glu Asn His 
            340                 345                 350         


Arg Gln Leu Gln Ala Arg Met Gly Asp Leu Lys Gly Val Leu Asp Asp 
        355                 360                 365             


Leu Gln Asp Asn Glu Val Leu Thr Glu Asn Glu Lys Glu Leu Val Glu 
    370                 375                 380                 


Gln Glu Lys Thr Arg Gln Ser Lys Asn Glu Ala Leu Leu Ser Met Val 
385                 390                 395                 400 


Glu Lys Lys Gly Asp Leu Ala Leu Asp Val Leu Phe Arg Ser Ile Ser 
                405                 410                 415     


Glu Arg Asp Pro Tyr Leu Val Ser Tyr Leu Arg Gln Gln Asn Leu 
            420                 425                 430     


<210>  8
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Thr Lys Thr Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Thr Asn Asp Thr Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Thr Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Thr Asn Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln 
385                 390                 395                 400 


His Phe Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu 
                405                 410                 415     


Glu Ile Thr Glu Lys Arg His Gly Thr Leu Val Trp Asp Thr Glu Val 
            420                 425                 430         


Lys Pro Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe 
        435                 440                 445             


Ser Gly Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg 
    450                 455                 460                 


Met Gly Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val 
465                 470                 475                 480 


Leu Thr Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Thr Arg Gln 
                485                 490                 495     


Ser Lys Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu 
            500                 505                 510         


Ala Leu Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu 
        515                 520                 525             


Val Ser Tyr Leu Arg Gln Gln Asn Leu 
    530                 535         


<210>  9
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Thr Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu Ala Glu 
        35                  40                  45              


Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly Gly Asp 
    50                  55                  60                  


Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln Asp Ser 
65                  70                  75                  80  


Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr Ala Ser 
                85                  90                  95      


Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln Phe Leu 
            100                 105                 110         


Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser Thr Asn 
        115                 120                 125             


Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp Ser Ala 
    130                 135                 140                 


Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr Ile Ala 
145                 150                 155                 160 


Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His His Glu 
                165                 170                 175     


Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu Pro Glu 
            180                 185                 190         


Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu Gln Ala 
        195                 200                 205             


Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys Asn Glu 
    210                 215                 220                 


Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr Ala Val 
225                 230                 235                 240 


Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg Ile Ala 
                245                 250                 255     


Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu Ile Tyr 
            260                 265                 270         


Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu Val Pro 
        275                 280                 285             


Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp Arg Phe 
    290                 295                 300                 


His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu Asn Phe 
305                 310                 315                 320 


Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val Met Pro 
                325                 330                 335     


Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln His Phe 
            340                 345                 350         


Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu Glu Ile 
        355                 360                 365             


Thr Glu Lys Arg His Gly Thr Leu Val Trp Asp Thr Glu Val Lys Pro 
    370                 375                 380                 


Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe Ser Gly 
385                 390                 395                 400 


Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg Met Gly 
                405                 410                 415     


Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val Leu Thr 
            420                 425                 430         


Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Thr Arg Gln Ser Lys 
        435                 440                 445             


Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu Ala Leu 
    450                 455                 460                 


Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu Val Ser 
465                 470                 475                 480 


Tyr Leu Arg Gln Gln Asn Leu 
                485         


<210>  10
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Thr Lys Thr Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Thr Asn Asp Thr Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Thr Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Thr Asn Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Trp Ile Ser Ser Leu 
385                 390         


<210>  11
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Thr Lys Thr Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Thr Asn Asp Thr Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Thr Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Thr Asn Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Trp Ile Ser Ser Leu 
385                 390         


<210>  12
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Thr Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu Ala Glu 
        35                  40                  45              


Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly Gly Asp 
    50                  55                  60                  


Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln Asp Ser 
65                  70                  75                  80  


Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr Ala Ser 
                85                  90                  95      


Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln Phe Leu 
            100                 105                 110         


Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser Thr Asn 
        115                 120                 125             


Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp Ser Ala 
    130                 135                 140                 


Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr Ile Ala 
145                 150                 155                 160 


Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His His Glu 
                165                 170                 175     


Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu Pro Glu 
            180                 185                 190         


Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu Gln Ala 
        195                 200                 205             


Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys Asn Glu 
    210                 215                 220                 


Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr Ala Val 
225                 230                 235                 240 


Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg Ile Ala 
                245                 250                 255     


Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu Ile Tyr 
            260                 265                 270         


Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu Val Pro 
        275                 280                 285             


Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp Arg Phe 
    290                 295                 300                 


His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu Asn Phe 
305                 310                 315                 320 


Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val Met Pro 
                325                 330                 335     


Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln His Phe 
            340                 345                 350         


Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu Glu Ile 
        355                 360                 365             


Thr Glu Lys Arg His Gly Thr Leu Val Trp Asp Thr Glu Val Lys Pro 
    370                 375                 380                 


Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe Ser Gly 
385                 390                 395                 400 


Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg Met Gly 
                405                 410                 415     


Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val Leu Thr 
            420                 425                 430         


Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Thr Arg Gln Ser Lys 
        435                 440                 445             


Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu Ala Leu 
    450                 455                 460                 


Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu Val Ser 
465                 470                 475                 480 


Tyr Leu Arg Gln Gln Asn Leu 
                485         


<210>  13
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  14
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  15
<211>  1177
<212>  PRT
<213>  Mus musculus

<400>  15

Met Glu Glu Ser Gln Tyr Lys Gln Glu His Asn Lys Lys Val Ala Gln 
1               5                   10                  15      


Asp Glu Gly Gln Glu Asp Lys Asp Thr Ile Phe Glu Thr Ile Glu Ala 
            20                  25                  30          


Ile Glu Ala Lys Leu Met Glu Leu Lys Thr Asn Pro Glu Ser Thr Phe 
        35                  40                  45              


Asn Tyr Gly Ile Phe Pro Glu Val Tyr Met Asn Gln Gly Glu Glu Ile 
    50                  55                  60                  


Leu Tyr Pro Ala Trp Ser Leu Lys Glu Glu Asn Leu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Ser Leu Arg Leu Phe Gln Lys Leu Cys Pro Arg Gly Ser Gly Asn 
                85                  90                  95      


Leu Val Lys Lys Ser Trp Tyr Pro Cys Val Pro Glu Glu Gly Gly His 
            100                 105                 110         


Ile Ile Asn Ile Gln Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys 
        115                 120                 125             


Glu Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser 
    130                 135                 140                 


Thr Leu Ala Arg Gln Val Lys Arg Ala Trp Met Glu Gly Glu Leu Tyr 
145                 150                 155                 160 


Arg Asp His Phe Gln His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala 
                165                 170                 175     


Gln Cys Lys Lys Leu Ser Leu Ala Glu Leu Ile Thr Gln Gly Gln Asp 
            180                 185                 190         


Val Pro Thr Ala Pro Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu 
        195                 200                 205             


Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp 
    210                 215                 220                 


Gln Asn Pro Glu Leu Cys Leu Tyr Trp Ser Gln Thr Gln Pro Val His 
225                 230                 235                 240 


Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Glu Ala Ser 
                245                 250                 255     


Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser 
            260                 265                 270         


Leu Pro Gln Ser Cys Gln Val Glu Val Leu Gly Phe Ser Asp Phe Glu 
        275                 280                 285             


Gln Glu Ile Tyr Ile Tyr Lys Tyr Phe Ala Lys Gln Ile Phe Gly Ile 
    290                 295                 300                 


Lys Ala Leu Met Met Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys 
305                 310                 315                 320 


Glu Val Pro Trp Val Cys Trp Leu Val Cys Asn Cys Leu Lys Lys Gln 
                325                 330                 335     


Met Glu Gln Gly Gly Asp Val Ser Leu Thr Ser Gln Thr Thr Thr Ala 
            340                 345                 350         


Ile Cys Leu Lys Tyr Ile Ser Leu Thr Ile Pro Val His His Met Arg 
        355                 360                 365             


Thr Gln Leu Arg Ala Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys 
    370                 375                 380                 


Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp 
385                 390                 395                 400 


Glu Asp Ala Val Ala Ile Phe Leu Lys Thr Gly Val Leu Gln Lys Gln 
                405                 410                 415     


Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe 
            420                 425                 430         


Phe Ala Ser Met Ser Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly 
        435                 440                 445             


Asp Met Glu Met Asp Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly 
    450                 455                 460                 


Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu 
465                 470                 475                 480 


Leu Ser Lys Glu Gly Leu Lys Glu Met Glu Lys Leu Phe Ser Cys Ser 
                485                 490                 495     


Leu Pro Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu Gly Lys 
            500                 505                 510         


Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys Leu Tyr 
        515                 520                 525             


Glu Asn Gln Asp Met Lys Leu Leu Thr His Val Met His Asp Leu Gln 
    530                 535                 540                 


Gly Thr Ile Val Pro Asp Thr Asp Asp Ile Thr His Thr Val Leu Gln 
545                 550                 555                 560 


Thr Asn Val Lys His Leu Val Val Arg Thr Asp Met Glu Leu Met Val 
                565                 570                 575     


Val Thr Phe Cys Ile Gln Phe Cys Ser His Met Arg Ser Leu Gln Leu 
            580                 585                 590         


Asn Met Glu Gly Gln Gln Gly Tyr Ala Leu Thr Ala Pro Arg Met Val 
        595                 600                 605             


Leu Tyr Arg Trp Thr Pro Ile Thr Asn Ala Ser Trp Lys Ile Leu Phe 
    610                 615                 620                 


Tyr Asn Leu Lys Phe Asn Ser Asn Leu Glu Gly Leu Asp Leu Ser Gly 
625                 630                 635                 640 


Asn Pro Leu Ser Tyr Ser Ala Val Gln Tyr Leu Cys Asp Ala Met Ile 
                645                 650                 655     


Tyr Pro Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys Gly Leu 
            660                 665                 670         


Thr Pro Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala Cys Ser 
        675                 680                 685             


Ser Leu Arg Glu Leu Asp Leu Gln Leu Asn Asp Leu Cys Asp Asp Gly 
    690                 695                 700                 


Val Arg Met Leu Cys Glu Gly Leu Arg Asn Arg Ala Cys Asn Leu Arg 
705                 710                 715                 720 


Ile Leu Arg Leu Asp Leu Tyr Ser Leu Ser Ala Gln Val Ile Thr Glu 
                725                 730                 735     


Leu Arg Thr Leu Glu Glu Asn Asn Leu Lys Leu His Ile Ser Ser Ile 
            740                 745                 750         


Trp Met Pro Gln Met Met Val Pro Thr Glu Asn Met Asp Glu Glu Asp 
        755                 760                 765             


Ile Leu Thr Ser Phe Lys Gln Gln Arg Gln Gln Ser Gly Ala Asn Pro 
    770                 775                 780                 


Met Glu Ile Leu Gly Thr Glu Glu Asp Phe Trp Gly Pro Ile Gly Pro 
785                 790                 795                 800 


Val Ala Thr Glu Val Val Tyr Arg Glu Arg Asn Leu Tyr Arg Val Gln 
                805                 810                 815     


Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser Thr Arg Leu His Phe 
            820                 825                 830         


Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser 
        835                 840                 845             


Gln Phe Leu Asp Lys Thr Pro Leu Gln Gln Ser His Met Val Val Gly 
    850                 855                 860                 


Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr 
865                 870                 875                 880 


Leu Pro His Phe Val Ser Leu Lys Asp Thr Lys Ala Ser Thr Phe Asp 
                885                 890                 895     


Phe Lys Val Ala His Phe Gln Glu His Gly Met Val Leu Glu Thr Pro 
            900                 905                 910         


Asp Arg Val Lys Pro Gly Tyr Thr Val Leu Lys Asn Pro Ser Phe Ser 
        915                 920                 925             


Pro Met Gly Val Val Leu Arg Ile Ile Pro Ala Ala Arg His Phe Ile 
    930                 935                 940                 


Pro Ile Thr Ser Ile Thr Leu Ile Tyr Tyr Arg Val Asn Gln Glu Glu 
945                 950                 955                 960 


Val Thr Leu His Leu Tyr Leu Val Pro Asn Asp Cys Thr Ile Gln Lys 
                965                 970                 975     


Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe Val Arg Ile Asn Lys 
            980                 985                 990         


Pro Pro Pro Val Asp Asn Leu Phe  Ile Gly Ser Arg Tyr  Ile Val Ser 
        995                 1000                 1005             


Gly Ser  Glu Asn Leu Glu Ile  Thr Pro Lys Glu Leu  Glu Leu Cys 
    1010                 1015                 1020             


Tyr Arg  Ser Ser Lys Glu Phe  Gln Leu Phe Ser Glu  Ile Tyr Val 
    1025                 1030                 1035             


Gly Asn  Met Gly Ser Glu Ile  Lys Leu Gln Ile Lys  Asn Lys Lys 
    1040                 1045                 1050             


His Met  Lys Leu Ile Trp Glu  Ala Leu Leu Lys Pro  Gly Asp Leu 
    1055                 1060                 1065             


Arg Pro  Ala Leu Pro Arg Ile  Ala Gln Ala Leu Lys  Asp Ala Pro 
    1070                 1075                 1080             


Ser Leu  Leu His Phe Met Asp  Gln His Arg Glu Gln  Leu Val Ala 
    1085                 1090                 1095             


Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp Lys Leu  His Gly Leu 
    1100                 1105                 1110             


Val Leu  Asn Glu Glu Ser Tyr  Glu Ala Val Arg Ala  Glu Asn Thr 
    1115                 1120                 1125             


Asn Gln  Asp Lys Met Arg Lys  Leu Phe Asn Leu Ser  Arg Ser Trp 
    1130                 1135                 1140             


Ser Arg  Ala Cys Lys Asp Leu  Phe Tyr Gln Ala Leu  Lys Glu Thr 
    1145                 1150                 1155             


His Pro  His Leu Val Met Asp  Leu Leu Glu Lys Ser  Gly Gly Val 
    1160                 1165                 1170             


Ser Leu  Gly Ser 
    1175         


<210>  16
<211>  1174
<212>  PRT
<213>  Mus musculus

<400>  16

Met Glu Gln Ser Gln Pro Lys Lys Lys Ser Arg Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Leu Asn Leu Asn Pro Thr Phe Lys Thr Arg Lys Arg 
            20                  25                  30          


Lys Glu Val Glu Leu Met Lys Arg Arg Pro Lys Pro Glu Gly His Leu 
        35                  40                  45              


Lys Leu Gly Thr Ile Pro Lys Val His Ile Lys Gln Lys Gly Glu Thr 
    50                  55                  60                  


Leu Asp Pro Thr Trp Ser Arg Lys Arg Lys Asn Leu Val Gln Lys Leu 
65                  70                  75                  80  


Thr Asn Leu Leu Leu Phe Glu Lys Leu Cys Ser Arg Gly Ser Glu Asn 
                85                  90                  95      


Leu Ile Arg Lys Ser Trp Tyr Ser Cys Glu Glu Glu Glu Arg Gly His 
            100                 105                 110         


Met Ile Glu Ile Gln Asp Leu Phe Gly Pro Asn Arg Gly Thr His Lys 
        115                 120                 125             


Lys Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser 
    130                 135                 140                 


Thr Leu Ala Arg Gln Val Lys Arg Ala Trp Lys Glu Gly Gln Leu Tyr 
145                 150                 155                 160 


Arg Asn His Phe Gln His Val Phe Phe Leu Ser Cys Arg Glu Leu Ala 
                165                 170                 175     


Gln Tyr Glu Gln Leu Ser Leu Ala Glu Leu Ile Ala Gln Gly Gln Glu 
            180                 185                 190         


Val Pro Thr Val Pro Ile Arg Gln Ile Leu Ser His Pro Lys Glu Leu 
        195                 200                 205             


Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp 
    210                 215                 220                 


Gln Asn Pro Glu Leu Cys Leu His Trp Ser Gln Arg Gln Pro Val His 
225                 230                 235                 240 


Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Gly Ala Ser 
                245                 250                 255     


Phe Leu Leu Thr Ala Arg Thr Thr Ala Leu Gln Lys Ile Ile Pro Tyr 
            260                 265                 270         


Val Gly Gln Pro Arg Arg Val Glu Val Leu Gly Phe Ser Lys Phe Glu 
        275                 280                 285             


Arg Glu Val Tyr Phe Arg Lys Tyr Phe Val Lys Glu Ser Asp Ala Ile 
    290                 295                 300                 


Ala Ala Phe Arg Leu Val Val Ser Asn Pro Val Leu Leu Thr Leu Cys 
305                 310                 315                 320 


Glu Val Pro Trp Val Cys Trp Leu Val Cys Thr Cys Leu Lys Lys Gln 
                325                 330                 335     


Met Glu Gln Gly Gly Glu Leu Ser Leu Thr Ser Gln Thr Thr Thr Ala 
            340                 345                 350         


Leu Cys Leu Lys Tyr Leu Ser Leu Thr Ile Pro Gly Gln His Met Arg 
        355                 360                 365             


Thr Gln Leu Arg Ala Leu Cys Ser Leu Ala Ala Glu Gly Ile Cys Gln 
    370                 375                 380                 


Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Ala 
385                 390                 395                 400 


Glu Asp Ala Ile Ala Thr Phe Leu Lys Ile Gly Ile Leu Gln Lys Gln 
                405                 410                 415     


Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe 
            420                 425                 430         


Phe Ala Val Met Ser Tyr Ile Leu Glu Asp Ser Asp Glu Arg Cys Asp 
        435                 440                 445             


Gly Met Glu Phe Lys Arg Thr Val Glu Thr Leu Ile Glu Val Tyr Gly 
    450                 455                 460                 


Arg His Thr Leu Cys Glu Glu Pro Thr Val His Phe Leu Phe Gly Leu 
465                 470                 475                 480 


Val Asn Glu Gln Gly Met Arg Glu Met Lys Lys Ile Phe Asp Cys Lys 
                485                 490                 495     


Leu Pro Leu Gly Thr Glu Leu Lys Met Leu Lys Ser Thr Leu Gly Asn 
            500                 505                 510         


Pro Thr Tyr Gln His His Leu Gly Leu Leu His Cys Leu Tyr Glu Ser 
        515                 520                 525             


Gln Glu Glu Val Leu Leu Thr Tyr Val Leu Cys Asn Leu His Leu Thr 
    530                 535                 540                 


Gly Pro Asp Lys Asn Tyr Met Glu Ala Thr Val Ser Gln Thr Asn Val 
545                 550                 555                 560 


Lys His Leu Val Ile Gln Thr Asp Met Glu Leu Met Val Val Thr Phe 
                565                 570                 575     


Cys Ile Gln Phe Cys Cys His Val Arg Ser Leu Arg Val Asn Met Lys 
            580                 585                 590         


Gly Gln Gln Gly His Lys Leu Thr Val Ala Ser Met Val Leu Tyr Arg 
        595                 600                 605             


Trp Thr Pro Ile Thr Asn Ala Ser Trp Lys Ile Leu Phe Tyr Asn Leu 
    610                 615                 620                 


Lys Phe Asn Ser Asn Leu Glu Gly Leu Asp Leu Ser Gly Asn Pro Leu 
625                 630                 635                 640 


Ser Tyr Ser Ala Val Gln Tyr Leu Cys Asp Ala Met Ile Tyr Pro Gly 
                645                 650                 655     


Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys Gly Leu Thr Pro Thr 
            660                 665                 670         


Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala Cys Ser Ser Leu Arg 
        675                 680                 685             


Glu Leu Asp Leu Gln Leu Asn Asp Leu Cys Asp Asp Gly Val Arg Met 
    690                 695                 700                 


Leu Cys Glu Gly Leu Arg Asn Arg Ala Cys Asn Leu Arg Ile Leu Arg 
705                 710                 715                 720 


Leu Asp Leu Tyr Ser Leu Ser Ala Gln Val Ile Thr Glu Leu Arg Thr 
                725                 730                 735     


Leu Glu Glu Asn Asn Leu Lys Leu His Ile Ser Ser Ile Trp Met Pro 
            740                 745                 750         


Gln Met Met Val Pro Thr Glu Asn Met Asp Glu Glu Asp Ile Leu Thr 
        755                 760                 765             


Ser Phe Lys Gln Gln Arg Gln Gln Ser Gly Ala Asn Pro Met Glu Ile 
    770                 775                 780                 


Leu Gly Thr Glu Glu Asp Phe Trp Gly Pro Ile Gly Pro Val Ala Thr 
785                 790                 795                 800 


Glu Val Val Tyr Arg Glu Arg Asn Leu Tyr Arg Val Gln Leu Pro Met 
                805                 810                 815     


Ala Gly Ser Tyr His Cys Pro Ser Thr Arg Leu His Phe Val Val Thr 
            820                 825                 830         


Arg Ala Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser Gln Phe Leu 
        835                 840                 845             


Asp Lys Thr Pro Leu Gln Gln Ser His Met Val Val Gly Pro Leu Phe 
    850                 855                 860                 


Asp Ile Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr Leu Pro His 
865                 870                 875                 880 


Phe Val Ser Leu Lys Asp Thr Lys Ala Ser Thr Phe Asp Phe Lys Val 
                885                 890                 895     


Ala His Phe Gln Glu His Gly Met Val Leu Glu Thr Pro Asp Arg Val 
            900                 905                 910         


Lys Pro Gly Tyr Thr Val Leu Lys Asn Pro Ser Phe Ser Pro Met Gly 
        915                 920                 925             


Val Val Leu Arg Ile Ile Pro Ala Ala Arg His Phe Ile Pro Ile Thr 
    930                 935                 940                 


Ser Ile Thr Leu Ile Tyr Tyr Arg Val Asn Gln Glu Glu Val Thr Leu 
945                 950                 955                 960 


His Leu Tyr Leu Val Pro Asn Asp Cys Thr Ile Gln Lys Ala Ile Asp 
                965                 970                 975     


Asp Glu Glu Met Lys Phe Gln Phe Val Arg Ile Asn Lys Pro Pro Pro 
            980                 985                 990         


Val Asp Asn Leu Phe Ile Gly Ser  Arg Tyr Ile Val Ser  Gly Ser Glu 
        995                 1000                 1005             


Asn Leu  Glu Ile Thr Pro Lys  Glu Leu Glu Leu Cys  Tyr Arg Ser 
    1010                 1015                 1020             


Ser Lys  Glu Phe Gln Leu Phe  Ser Glu Ile Tyr Val  Gly Asn Met 
    1025                 1030                 1035             


Gly Ser  Glu Ile Lys Leu Gln  Ile Lys Asn Lys Lys  His Met Lys 
    1040                 1045                 1050             


Leu Ile  Trp Glu Ala Leu Leu  Lys Pro Gly Asp Leu  Arg Pro Ala 
    1055                 1060                 1065             


Leu Pro  Arg Ile Ala Gln Ala  Leu Lys Asp Ala Pro  Ser Leu Leu 
    1070                 1075                 1080             


His Phe  Met Asp Gln His Arg  Glu Gln Leu Val Ala  Arg Val Thr 
    1085                 1090                 1095             


Ser Val  Asp Pro Leu Leu Asp  Lys Leu His Gly Leu  Val Leu Asn 
    1100                 1105                 1110             


Glu Glu  Ser Tyr Glu Ala Val  Arg Ala Glu Asn Thr  Asn Gln Asp 
    1115                 1120                 1125             


Lys Met  Arg Lys Leu Phe Asn  Leu Ser Arg Ser Trp  Ser Arg Ala 
    1130                 1135                 1140             


Cys Lys  Asp Leu Phe Tyr Gln  Ala Leu Lys Glu Thr  His Pro His 
    1145                 1150                 1155             


Leu Val  Met Asp Leu Leu Glu  Lys Ser Gly Gly Val  Ser Leu Gly 
    1160                 1165                 1170             


Ser 
    


<210>  17
<211>  1177
<212>  PRT
<213>  Mus musculus

<400>  17

Met Glu Glu Ser Gln Tyr Lys Gln Glu His Asn Lys Lys Val Ala Gln 
1               5                   10                  15      


Asp Glu Gly Gln Glu Asp Lys Asp Thr Ile Phe Glu Thr Ile Glu Ala 
            20                  25                  30          


Ile Glu Ala Lys Leu Met Glu Leu Lys Thr Asn Pro Glu Ser Thr Phe 
        35                  40                  45              


Asn Tyr Gly Ile Phe Pro Glu Val Tyr Met Asn Gln Gly Glu Glu Ile 
    50                  55                  60                  


Leu Tyr Pro Ala Trp Ser Leu Lys Glu Glu Asn Leu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Ser Leu Arg Leu Phe Gln Lys Leu Cys Pro Arg Gly Ser Gly Asn 
                85                  90                  95      


Leu Val Lys Lys Ser Trp Tyr Pro Cys Val Pro Glu Glu Gly Gly His 
            100                 105                 110         


Ile Ile Asn Ile Gln Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys 
        115                 120                 125             


Glu Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser 
    130                 135                 140                 


Thr Leu Ala Arg Gln Val Lys Arg Ala Trp Met Glu Gly Glu Leu Tyr 
145                 150                 155                 160 


Arg Asp His Phe Gln His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala 
                165                 170                 175     


Gln Cys Lys Lys Leu Ser Leu Ala Glu Leu Ile Thr Gln Gly Gln Asp 
            180                 185                 190         


Val Pro Thr Ala Pro Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu 
        195                 200                 205             


Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp 
    210                 215                 220                 


Gln Asn Pro Glu Leu Cys Leu Tyr Trp Ser Gln Thr Gln Pro Val His 
225                 230                 235                 240 


Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Glu Ala Ser 
                245                 250                 255     


Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser 
            260                 265                 270         


Leu Pro Gln Ser Cys Gln Val Glu Val Leu Gly Phe Ser Asp Phe Glu 
        275                 280                 285             


Gln Glu Ile Tyr Ile Tyr Lys Tyr Phe Ala Lys Gln Ile Phe Gly Ile 
    290                 295                 300                 


Lys Ala Leu Met Met Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys 
305                 310                 315                 320 


Glu Val Pro Trp Val Cys Trp Leu Val Cys Asn Cys Leu Lys Lys Gln 
                325                 330                 335     


Met Glu Gln Gly Gly Asp Val Ser Leu Thr Ser Gln Thr Thr Thr Ala 
            340                 345                 350         


Ile Cys Leu Lys Tyr Ile Ser Leu Thr Ile Pro Val His His Met Arg 
        355                 360                 365             


Thr Gln Leu Arg Ala Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys 
    370                 375                 380                 


Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp 
385                 390                 395                 400 


Glu Asp Ala Val Ala Ile Phe Leu Lys Thr Gly Val Leu Gln Lys Gln 
                405                 410                 415     


Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe 
            420                 425                 430         


Phe Ala Ser Met Ser Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly 
        435                 440                 445             


Asp Met Glu Met Asp Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly 
    450                 455                 460                 


Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu 
465                 470                 475                 480 


Leu Ser Lys Glu Gly Leu Lys Glu Met Glu Lys Leu Phe Ser Cys Ser 
                485                 490                 495     


Leu Pro Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu Gly Lys 
            500                 505                 510         


Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys Leu Tyr 
        515                 520                 525             


Glu Asn Gln Asp Met Lys Leu Leu Thr His Val Met His Asp Leu Gln 
    530                 535                 540                 


Gly Thr Ile Val Pro Asp Thr Asp Asp Ile Thr His Thr Val Leu Gln 
545                 550                 555                 560 


Thr Asn Val Lys His Leu Val Val Arg Thr Asp Met Glu Leu Met Val 
                565                 570                 575     


Val Thr Phe Cys Ile Gln Phe Cys Ser His Met Arg Ser Leu Gln Leu 
            580                 585                 590         


Asn Met Glu Gly Gln Gln Gly Tyr Ala Leu Thr Ala Pro Arg Met Val 
        595                 600                 605             


Leu Tyr Arg Trp Thr Pro Ile Thr Asn Ala Ser Trp Lys Ile Leu Phe 
    610                 615                 620                 


Tyr Asn Leu Lys Phe Asn Ser Asn Leu Glu Gly Leu Asp Leu Ser Gly 
625                 630                 635                 640 


Asn Pro Leu Ser Tyr Ser Ala Val Gln Tyr Leu Cys Asp Ala Met Ile 
                645                 650                 655     


Tyr Pro Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys Gly Leu 
            660                 665                 670         


Thr Pro Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala Cys Ser 
        675                 680                 685             


Ser Leu Arg Glu Leu Asp Leu Gln Leu Asn Asp Leu Cys Asp Asp Gly 
    690                 695                 700                 


Val Arg Met Leu Cys Glu Gly Leu Arg Asn Arg Ala Cys Asn Leu Arg 
705                 710                 715                 720 


Ile Leu Arg Leu Asp Leu Tyr Ser Leu Ser Ala Gln Val Ile Thr Glu 
                725                 730                 735     


Leu Arg Thr Leu Glu Glu Asn Asn Leu Lys Leu His Ile Ser Ser Ile 
            740                 745                 750         


Trp Met Pro Gln Met Met Val Pro Thr Glu Asn Met Asp Glu Glu Asp 
        755                 760                 765             


Ile Leu Thr Ser Phe Lys Gln Gln Arg Gln Gln Ser Gly Ala Asn Pro 
    770                 775                 780                 


Met Glu Ile Leu Gly Thr Glu Glu Asp Phe Trp Gly Pro Ile Gly Pro 
785                 790                 795                 800 


Val Ala Thr Glu Val Val Tyr Arg Glu Arg Asn Leu Tyr Arg Val Gln 
                805                 810                 815     


Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser Thr Arg Leu His Phe 
            820                 825                 830         


Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser 
        835                 840                 845             


Gln Phe Leu Asp Lys Thr Pro Leu Gln Gln Ser His Met Val Val Gly 
    850                 855                 860                 


Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr 
865                 870                 875                 880 


Leu Pro His Phe Val Ser Leu Lys Asp Thr Lys Ala Ser Thr Phe Asp 
                885                 890                 895     


Phe Lys Val Ala His Phe Gln Glu His Gly Met Val Leu Glu Thr Pro 
            900                 905                 910         


Asp Arg Val Lys Pro Gly Tyr Thr Val Leu Lys Asn Pro Ser Phe Ser 
        915                 920                 925             


Pro Met Gly Val Val Leu Arg Ile Ile Pro Ala Ala Arg His Phe Ile 
    930                 935                 940                 


Pro Ile Thr Ser Ile Thr Leu Ile Tyr Tyr Arg Val Asn Gln Glu Glu 
945                 950                 955                 960 


Val Thr Leu His Leu Tyr Leu Val Pro Asn Asp Cys Thr Ile Gln Lys 
                965                 970                 975     


Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe Val Arg Ile Asn Lys 
            980                 985                 990         


Pro Pro Pro Val Asp Asn Leu Phe  Ile Gly Ser Arg Tyr  Ile Val Ser 
        995                 1000                 1005             


Gly Ser  Glu Asn Leu Glu Ile  Thr Pro Lys Glu Leu  Glu Leu Cys 
    1010                 1015                 1020             


Tyr Arg  Ser Ser Lys Glu Phe  Gln Leu Phe Ser Glu  Ile Tyr Val 
    1025                 1030                 1035             


Gly Asn  Met Gly Ser Glu Ile  Lys Leu Gln Ile Lys  Asn Lys Lys 
    1040                 1045                 1050             


His Met  Lys Leu Ile Trp Glu  Ala Leu Leu Lys Pro  Gly Asp Leu 
    1055                 1060                 1065             


Arg Pro  Ala Leu Pro Arg Ile  Ala Gln Ala Leu Lys  Asp Ala Pro 
    1070                 1075                 1080             


Ser Leu  Leu His Phe Met Asp  Gln His Arg Glu Gln  Leu Val Ala 
    1085                 1090                 1095             


Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp Lys Leu  His Gly Leu 
    1100                 1105                 1110             


Val Leu  Asn Glu Glu Ser Tyr  Glu Ala Val Arg Ala  Glu Asn Thr 
    1115                 1120                 1125             


Asn Gln  Asp Lys Met Arg Lys  Leu Phe Asn Leu Ser  Arg Ser Trp 
    1130                 1135                 1140             


Ser Arg  Ala Cys Lys Asp Leu  Phe Tyr Gln Ala Leu  Lys Glu Thr 
    1145                 1150                 1155             


His Pro  His Leu Val Met Asp  Leu Leu Glu Lys Ser  Gly Gly Val 
    1160                 1165                 1170             


Ser Leu  Gly Ser 
    1175         


<210>  18
<211>  1196
<212>  PRT
<213>  Mus musculus

<400>  18

Met Glu Glu Ser Pro Pro Lys Gln Lys Ser Asn Thr Lys Val Thr Gln 
1               5                   10                  15      


His Glu Gly Gln Gln Asp Leu Asn Thr Thr Arg His Met Asn Val Glu 
            20                  25                  30          


Leu Lys His Arg Pro Lys Leu Glu Arg His Leu Lys Leu Gly Met Ile 
        35                  40                  45              


Pro Val Val Tyr Met Lys Gln Gly Glu Glu Ile Leu Tyr Pro Ala Gln 
    50                  55                  60                  


Ser Leu Arg Glu Glu Asn Leu Ile Gln Asn Phe Thr Ser Leu Leu Leu 
65                  70                  75                  80  


Leu Gln Lys Leu Cys Pro Lys Asp Pro Glu Asn Met Val Arg Lys Ser 
                85                  90                  95      


Trp Ala Ser Cys Val Pro Glu Glu Gly Gly His Met Ile Asn Ile Gln 
            100                 105                 110         


Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys Glu Pro Gln Leu Val 
        115                 120                 125             


Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser Thr Leu Ala Arg Leu 
    130                 135                 140                 


Val Lys Arg Ala Trp Lys Glu Gly Gln Leu Tyr Arg Asp His Phe Gln 
145                 150                 155                 160 


His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala Gln Cys Lys Lys Leu 
                165                 170                 175     


Ser Leu Ala Glu Leu Ile Ala Gln Gly Gln Glu Val Pro Thr Ala Pro 
            180                 185                 190         


Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu Leu Phe Ile Leu Asp 
        195                 200                 205             


Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp Gln Asn Pro Glu Leu 
    210                 215                 220                 


Cys Leu His Trp Ser Gln Arg Gln Pro Val His Thr Leu Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Gly Lys Ser Ile Phe Pro Glu Ala Phe Phe Leu Leu Thr Thr 
                245                 250                 255     


Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser Leu Pro Met Pro Cys 
            260                 265                 270         


Gln Val Glu Val Leu Gly Phe Ser Gly Ile Glu Arg Glu Asn Tyr Phe 
        275                 280                 285             


Tyr Lys Tyr Phe Ala Asn Gln Arg His Ala Ile Thr Ala Phe Met Met 
    290                 295                 300                 


Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys Glu Val Pro Trp Val 
305                 310                 315                 320 


Cys Trp Leu Val Cys Thr Cys Leu Lys Lys Gln Met Glu Gln Gly Arg 
                325                 330                 335     


Val Leu Ser Leu Lys Ser Gln Thr Thr Thr Ala Leu Cys Leu Lys Tyr 
            340                 345                 350         


Leu Ser Leu Thr Ile Pro Asp Lys His Arg Arg Thr Gln Val Lys Ala 
        355                 360                 365             


Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys Arg Arg Thr Leu Phe 
    370                 375                 380                 


Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp Glu Asp Ala Val Ala 
385                 390                 395                 400 


Thr Phe Leu Lys Thr Gly Val Leu Gln Lys Gln Ala Ser Ser Leu Ser 
                405                 410                 415     


Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe Phe Ala Ala Ile Ser 
            420                 425                 430         


Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly Asn Met Glu Met Asp 
        435                 440                 445             


Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly Arg Gln Asn Leu Phe 
    450                 455                 460                 


Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu Leu Gly Lys Glu Gly 
465                 470                 475                 480 


Val Lys Gly Met Glu Lys Leu Phe Ser Cys Ser Leu His Gly Lys Thr 
                485                 490                 495     


Asn Leu Lys Leu Leu Trp His Ile Leu Val Lys Ser Gln Pro His Gln 
            500                 505                 510         


Pro Pro Cys Leu Gly Leu Leu His Cys Leu Tyr Glu Asn Gln Asp Met 
        515                 520                 525             


Glu Leu Leu Thr His Val Met His Asp Leu Gln Gly Thr Ile Val Pro 
    530                 535                 540                 


Gly Pro Asn Asp Ile Ala His Thr Val Leu Gln Thr Asn Val Lys His 
545                 550                 555                 560 


Leu Val Val Gln Thr Asp Met Glu Leu Met Val Ala Thr Phe Cys Ile 
                565                 570                 575     


Gln Phe Tyr Cys His Val Arg Thr Leu Gln Leu Asn Met Glu Lys Gln 
            580                 585                 590         


Gln Gly Tyr Ala Leu Ile Ser Pro Arg Met Val Leu Tyr Arg Trp Thr 
        595                 600                 605             


Pro Ile Thr Asn Ala Ser Trp Glu Ile Leu Phe Tyr Asn Leu Lys Phe 
    610                 615                 620                 


Thr Arg Asn Leu Glu Gly Leu Asp Leu Ser Gly Asn Ser Leu Arg Tyr 
625                 630                 635                 640 


Ser Val Val Gln Ser Leu Cys Asn Thr Leu Arg Tyr Pro Gly Cys Gln 
                645                 650                 655     


Leu Lys Thr Leu Trp Leu Val Lys Cys Gly Leu Thr Ser Arg His Cys 
            660                 665                 670         


Ser Leu Leu Ala Ser Val Leu Ser Ala His Ser Ser Leu Thr Glu Leu 
        675                 680                 685             


Tyr Leu Gln Leu Asn Asp Leu Gly Asp Asp Gly Val Arg Met Leu Cys 
    690                 695                 700                 


Glu Gly Leu Arg Asn Pro Val Cys Asn Leu Ser Ile Leu Trp Leu Asp 
705                 710                 715                 720 


Leu Tyr Ser Leu Ser Ala Gln Val Ile Thr Glu Leu Arg Thr Leu Glu 
                725                 730                 735     


Glu Lys Asn Pro Lys Leu Tyr Ile Arg Ser Ile Trp Met Pro His Met 
            740                 745                 750         


Met Val Pro Thr Glu Asn Met Asp Glu Glu Ala Ile Leu Thr Thr Phe 
        755                 760                 765             


Lys Gln Gln Arg Gln Glu Pro Gly Asp Lys Pro Met Glu Ile Leu Gly 
    770                 775                 780                 


Thr Glu Glu Asp Phe Trp Gly Pro Thr Gly Pro Val Ala Thr Glu Leu 
785                 790                 795                 800 


Val Asp Arg Val Arg Asn Leu Tyr Arg Val Gln Leu Pro Met Ala Gly 
                805                 810                 815     


Ser Tyr His Cys Pro Ser Thr Gly Leu His Phe Val Val Thr Arg Ala 
            820                 825                 830         


Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser Gln Phe Leu Asp Lys 
        835                 840                 845             


Thr Pro Leu Gln Gln Ser His Met Val Val Gly Pro Leu Phe Asp Ile 
    850                 855                 860                 


Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr Leu Pro His Phe Val 
865                 870                 875                 880 


Ser Leu Lys Asp Thr Glu Ala Ser Thr Phe Asp Phe Lys Val Ala His 
                885                 890                 895     


Phe Gln Glu His Gly Met Val Leu Glu Thr Pro Asp Arg Val Lys Pro 
            900                 905                 910         


Gly Tyr Thr Val Leu Lys Asn Pro Ser Phe Ser Pro Met Gly Val Val 
        915                 920                 925             


Leu Arg Ile Ile Pro Ala Ala Arg His Phe Ile Pro Ile Thr Ser Ile 
    930                 935                 940                 


Thr Leu Ile Tyr Tyr Arg Leu Asn Leu Glu Glu Val Thr Leu His Leu 
945                 950                 955                 960 


Tyr Leu Val Pro Asn Asp Cys Thr Ile Gln Lys Ala Ile Asp Asp Glu 
                965                 970                 975     


Glu Met Lys Phe Gln Phe Val Arg Ile Asn Lys Pro Pro Pro Val Asp 
            980                 985                 990         


Asn Leu Phe Ile Gly Ser Arg Tyr  Ile Val Ser Gly Ser  Glu Asn Leu 
        995                 1000                 1005             


Glu Ile  Thr Pro Lys Glu Leu  Glu Leu Cys Tyr Arg  Ser Ser Lys 
    1010                 1015                 1020             


Glu Phe  Gln Leu Phe Ser Glu  Ile Tyr Val Gly Asn  Met Gly Ser 
    1025                 1030                 1035             


Glu Ile  Lys Leu Gln Ile Lys  Asn Lys Lys His Met  Lys Leu Ile 
    1040                 1045                 1050             


Trp Glu  Ala Leu Leu Lys Pro  Glu Phe Lys Phe Asp  His Leu Cys 
    1055                 1060                 1065             


Asp Gln  Glu Phe Cys Thr Ile  Leu Lys Asn Ile Met  Ile Ser Pro 
    1070                 1075                 1080             


Ala Gly  Asp Leu Arg Pro Ala  Leu Pro Arg Ile Ala  Gln Ala Leu 
    1085                 1090                 1095             


Lys Asp  Ala Pro Ser Leu Leu  His Phe Met Asp Gln  His Arg Glu 
    1100                 1105                 1110             


Gln Leu  Val Ala Arg Val Thr  Ser Val Asp Pro Leu  Leu Asp Lys 
    1115                 1120                 1125             


Leu His  Gly Leu Val Leu Asn  Glu Glu Ser Tyr Glu  Ala Val Arg 
    1130                 1135                 1140             


Ala Glu  Asn Thr Asn Gln Asp  Lys Met Arg Lys Leu  Phe Asn Leu 
    1145                 1150                 1155             


Ser Arg  Ser Trp Ser Arg Ala  Cys Lys Asp Leu Phe  Tyr Gln Ala 
    1160                 1165                 1170             


Leu Lys  Glu Thr His Pro His  Leu Val Met Asp Leu  Phe Glu Lys 
    1175                 1180                 1185             


Ser Gly  Gly Val Ser Leu Gly  Ser 
    1190                 1195     


<210>  19
<211>  1182
<212>  PRT
<213>  Mus musculus

<400>  19

Met Glu Glu Ser Gln Ser Lys Gln Glu Ser Ser Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Glu Asp Val Asp Pro Thr Phe Lys Thr Lys Lys Leu 
            20                  25                  30          


Met Glu Val Glu Leu Met Lys His Arg Val Gln Leu Glu Arg Asn Leu 
        35                  40                  45              


Lys Leu Arg Thr Phe Pro Gly Ala Arg Thr Lys Gln Val Lys Glu Ala 
    50                  55                  60                  


Leu Tyr Pro Leu Leu Thr Trp Ser Ser Lys Ser Lys Asn Leu Phe Gln 
65                  70                  75                  80  


Asn Phe Thr Lys Leu Leu Leu Phe Lys Lys Leu Cys Gln Arg Gly Ser 
                85                  90                  95      


Glu Asn Leu Val Arg Glu Ser Trp Tyr Pro Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ala His Met Ile Asp Ile Gln Asp Leu Phe Gly Pro Asn Leu Gly Thr 
        115                 120                 125             


Gln Lys Lys Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly 
    130                 135                 140                 


Lys Ser Thr Leu Ala Arg Leu Val Lys Arg Ala Trp Lys Glu Gly Lys 
145                 150                 155                 160 


Leu Tyr Arg Asn Asp Phe His His Val Phe Phe Phe Ser Cys Arg Glu 
                165                 170                 175     


Leu Ala Gln Tyr Glu Gln Leu Ser Leu Ala Glu Leu Ile Val Gln Gly 
            180                 185                 190         


Gln Glu Val Pro Thr Ala Pro Ile Arg Gln Ile Leu Ser His Pro Glu 
        195                 200                 205             


Lys Leu Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu 
    210                 215                 220                 


Ala Asp Gln Asn Pro Glu Leu Cys Leu His Trp Ser Gln Thr Gln Pro 
225                 230                 235                 240 


Val His Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Gly 
                245                 250                 255     


Ala Ser Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile 
            260                 265                 270         


Pro Ser Leu Glu Gln Pro Cys Gln Val Glu Val Leu Gly Phe Thr Leu 
        275                 280                 285             


Phe Glu Arg Lys Asn Tyr Phe Tyr Lys Tyr Phe Gly Lys Lys Lys Gly 
    290                 295                 300                 


Gly Val Thr Thr Phe Thr Leu Val Lys Ser Asn Ser Ala Leu Leu Thr 
305                 310                 315                 320 


Leu Cys Glu Val Pro Trp Val Cys Trp Leu Val Cys Thr Cys Leu Lys 
                325                 330                 335     


Lys Gln Met Glu Gln Gly Gly Glu Leu Ser Leu Thr Ser Gln Thr Thr 
            340                 345                 350         


Thr Ala Leu Cys Leu Lys Tyr Leu Ser Leu Thr Ile Pro Gly Gln His 
        355                 360                 365             


Met Arg Thr Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala Glu Gly Val 
    370                 375                 380                 


Cys Gln Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly 
385                 390                 395                 400 


Leu Asp Glu His Ala Ile Ala Ser Phe Leu Lys Ile Gly Val Leu Gln 
                405                 410                 415     


Lys Gln Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln 
            420                 425                 430         


Glu Phe Phe Ala Ala Met Ser Tyr Ile Leu Asp Asp Ser Glu Glu Arg 
        435                 440                 445             


His Ala Asp Met Lys Asn Asp Arg Ile Val Glu Thr Leu Val Glu Arg 
    450                 455                 460                 


Tyr Gly Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe 
465                 470                 475                 480 


Gly Leu Leu Ser Lys Glu Glu Leu Lys Lys Ile Glu Lys Leu Phe Ser 
                485                 490                 495     


Cys Ser Leu His Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu 
            500                 505                 510         


Gly Lys Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys 
        515                 520                 525             


Leu Tyr Glu Asn Gln Asp Met Glu Leu Leu Thr His Val Met His Asp 
    530                 535                 540                 


Leu Gln Gly Thr Ile Val Pro Gly Pro Asp Asp Leu Ala His Thr Val 
545                 550                 555                 560 


Leu Gln Thr Asn Val Lys His Leu Val Ile Gln Thr Asp Met Asp Leu 
                565                 570                 575     


Met Val Val Thr Phe Cys Ile Lys Phe Cys Cys His Val Arg Ser Leu 
            580                 585                 590         


Gln Leu Asn Arg Lys Val Gln Gln Gly His Lys Phe Thr Ala Pro Gly 
        595                 600                 605             


Met Val Leu Tyr Arg Trp Thr Pro Ile Thr Asp Ala Ser Trp Lys Ile 
    610                 615                 620                 


Phe Phe Ser Asn Leu Lys Leu Ala Arg Asn Leu Glu Glu Leu Asp Leu 
625                 630                 635                 640 


Ser Gly Asn Pro Leu Ser Tyr Tyr Ala Val His Ser Leu Cys Thr Thr 
                645                 650                 655     


Leu Arg Lys Arg Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys 
            660                 665                 670         


Gly Leu Thr Ser Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala 
        675                 680                 685             


Arg Ser Ser Leu Thr Glu Leu Asp Leu Gln Leu Asn Asp Leu Gly Asp 
    690                 695                 700                 


Gly Gly Val Lys Met Leu Cys Glu Gly Leu Arg Asn Pro Ala Cys Asn 
705                 710                 715                 720 


Leu Ser Ile Leu Trp Leu Asp Gln Ala Ser Leu Ser Asp Gln Val Ile 
                725                 730                 735     


Ala Glu Leu Arg Thr Leu Glu Ala Lys Asn Pro Lys Leu Leu Ile Ser 
            740                 745                 750         


Ser Thr Trp Lys Pro His Val Met Val Pro Thr Met Asn Met Asp Lys 
        755                 760                 765             


Glu Glu Val Gly Asp Ser Gln Ala Leu Leu Lys Gln Gln Arg Gln Gln 
    770                 775                 780                 


Ser Gly Asp Lys His Met Glu Pro Leu Gly Thr Glu Asp Glu Phe Trp 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Val Thr Thr Glu Val Val Asp Arg Glu Arg Asn 
                805                 810                 815     


Leu Tyr Arg Val Gln Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser 
            820                 825                 830         


Thr Gly Leu His Phe Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu 
        835                 840                 845             


Phe Cys Ala Trp Ser Gln Tyr Leu Asp Lys Thr Pro Leu Gln Gln Ser 
    850                 855                 860                 


His Met Val Val Gly Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala 
865                 870                 875                 880 


Val Thr Ala Val Tyr Leu Pro His Phe Val Ala Leu Gln Glu Gly Ile 
                885                 890                 895     


Val Asp Ser Ser Leu Phe His Val Ala His Phe Gln Glu His Gly Met 
            900                 905                 910         


Val Leu Glu Thr Pro Ala Arg Val Glu Gln His Tyr Ala Val Leu Glu 
        915                 920                 925             


Asn Pro Ser Phe Ser Pro Met Gly Ile Leu Leu Arg Met Ile Pro Ala 
    930                 935                 940                 


Val Gly His Phe Ile Pro Ile Thr Ser Thr Thr Leu Ile Tyr Tyr His 
945                 950                 955                 960 


Leu Tyr Leu Glu Asp Val Thr Phe His Leu Tyr Leu Val Pro Asn Asp 
                965                 970                 975     


Cys Ser Ile Arg Lys Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe 
            980                 985                 990         


Val Arg Ile Asn Lys Pro Pro Pro  Val Asp Ala Leu Tyr  Leu Gly Ser 
        995                 1000                 1005             


Arg Tyr  Ile Val Ser Ser Ser  Lys Leu Val Glu Ile  Ile Pro Lys 
    1010                 1015                 1020             


Glu Leu  Glu Leu Cys Tyr Arg  Ser Pro Gly Glu Ser  Gln Leu Phe 
    1025                 1030                 1035             


Ser Glu  Ile Asp Ile Gly His  Met Asp Ser Glu Ile  Lys Leu Gln 
    1040                 1045                 1050             


Ile Lys  Asp Lys Arg His Met  Asn Leu Lys Trp Glu  Ala Leu Leu 
    1055                 1060                 1065             


Lys Pro  Gly Asp Leu Arg Pro  Ala Leu Pro Lys Ile  Ala Thr Ala 
    1070                 1075                 1080             


Pro Lys  Asp Ala Pro Ser Leu  Leu His Phe Met Asp  Gln His Arg 
    1085                 1090                 1095             


Glu Gln  Leu Val Ala Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp 
    1100                 1105                 1110             


Lys Leu  His Gly Leu Val Leu  Ser Glu Asp Ser Tyr  Glu Val Val 
    1115                 1120                 1125             


Arg Ser  Glu Thr Thr Asn Gln  Asp Lys Met Arg Lys  Leu Phe Ser 
    1130                 1135                 1140             


Leu Ser  Arg Ser Trp Ser Trp  Asp Cys Lys Asp Gln  Phe Tyr Gln 
    1145                 1150                 1155             


Ala Leu  Lys Glu Thr His Pro  His Leu Val Met Asp  Ile Leu Glu 
    1160                 1165                 1170             


Lys Leu  Gly Gly Val Ser Val  Lys Ser 
    1175                 1180         


<210>  20
<211>  1182
<212>  PRT
<213>  Mus musculus

<400>  20

Met Glu Glu Ser Gln Ser Lys Gln Glu Ser Ser Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Glu Asp Val Asp Pro Thr Phe Lys Thr Lys Lys Leu 
            20                  25                  30          


Met Glu Val Glu Leu Met Lys His Arg Val Gln Leu Glu Arg Asn Leu 
        35                  40                  45              


Lys Leu Arg Thr Phe Pro Gly Ala Arg Thr Lys Gln Val Lys Glu Ala 
    50                  55                  60                  


Leu Tyr Pro Leu Leu Thr Trp Ser Ser Lys Ser Lys Asn Leu Phe Gln 
65                  70                  75                  80  


Asn Phe Thr Lys Leu Leu Leu Phe Lys Lys Leu Cys Gln Arg Gly Ser 
                85                  90                  95      


Glu Asn Leu Val Arg Glu Ser Trp Tyr Pro Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ala His Met Ile Asp Ile Gln Asp Leu Phe Gly Pro Asn Leu Gly Thr 
        115                 120                 125             


Gln Lys Lys Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly 
    130                 135                 140                 


Lys Ser Thr Leu Ala Arg Leu Val Lys Arg Ala Trp Lys Glu Gly Lys 
145                 150                 155                 160 


Leu Tyr Arg Asn Asp Phe His His Val Phe Phe Phe Ser Cys Arg Glu 
                165                 170                 175     


Leu Ala Gln Tyr Glu Gln Leu Ser Leu Ala Glu Leu Ile Val Gln Gly 
            180                 185                 190         


Gln Glu Val Pro Thr Ala Pro Ile Arg Gln Ile Leu Ser His Pro Glu 
        195                 200                 205             


Lys Leu Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu 
    210                 215                 220                 


Ala Asp Gln Asn Pro Glu Leu Cys Leu His Trp Ser Gln Thr Gln Pro 
225                 230                 235                 240 


Val His Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Gly 
                245                 250                 255     


Ala Ser Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile 
            260                 265                 270         


Pro Ser Leu Glu Gln Pro Cys Gln Val Glu Val Leu Gly Phe Thr Leu 
        275                 280                 285             


Phe Glu Arg Lys Asn Tyr Phe Tyr Lys Tyr Phe Gly Lys Lys Lys Gly 
    290                 295                 300                 


Gly Val Thr Thr Phe Thr Leu Val Lys Ser Asn Ser Ala Leu Leu Thr 
305                 310                 315                 320 


Leu Cys Glu Val Pro Trp Val Cys Trp Leu Val Cys Thr Cys Leu Lys 
                325                 330                 335     


Lys Gln Met Glu Gln Gly Gly Glu Leu Ser Leu Thr Ser Gln Thr Thr 
            340                 345                 350         


Thr Ala Leu Cys Leu Lys Tyr Leu Ser Leu Thr Ile Pro Gly Gln His 
        355                 360                 365             


Met Arg Thr Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala Glu Gly Val 
    370                 375                 380                 


Cys Gln Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly 
385                 390                 395                 400 


Leu Asp Glu His Ala Ile Ala Ser Phe Leu Lys Ile Gly Val Leu Gln 
                405                 410                 415     


Lys Gln Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln 
            420                 425                 430         


Glu Phe Phe Ala Ala Met Ser Tyr Ile Leu Asp Asp Ser Glu Glu Arg 
        435                 440                 445             


His Ala Asp Met Lys Asn Asp Arg Ile Val Glu Thr Leu Val Glu Arg 
    450                 455                 460                 


Tyr Gly Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe 
465                 470                 475                 480 


Gly Leu Leu Ser Lys Glu Glu Leu Lys Lys Ile Glu Lys Leu Phe Ser 
                485                 490                 495     


Cys Ser Leu His Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu 
            500                 505                 510         


Gly Lys Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys 
        515                 520                 525             


Leu Tyr Glu Asn Gln Asp Met Glu Leu Leu Thr His Val Met His Asp 
    530                 535                 540                 


Leu Gln Gly Thr Ile Val Pro Gly Pro Asp Asp Leu Ala His Thr Val 
545                 550                 555                 560 


Leu Gln Thr Asn Val Lys His Leu Val Ile Gln Thr Asp Met Asp Leu 
                565                 570                 575     


Met Val Val Thr Phe Cys Ile Lys Phe Cys Cys His Val Arg Ser Leu 
            580                 585                 590         


Gln Leu Asn Arg Lys Val Gln Gln Gly His Lys Phe Thr Ala Pro Gly 
        595                 600                 605             


Met Val Leu Tyr Arg Trp Thr Pro Ile Thr Asp Ala Ser Trp Lys Ile 
    610                 615                 620                 


Phe Phe Ser Asn Leu Lys Leu Ala Arg Asn Leu Glu Glu Leu Asp Leu 
625                 630                 635                 640 


Ser Gly Asn Pro Leu Ser Tyr Tyr Ala Val His Ser Leu Cys Thr Thr 
                645                 650                 655     


Leu Arg Lys Arg Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys 
            660                 665                 670         


Gly Leu Thr Ser Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala 
        675                 680                 685             


Arg Ser Ser Leu Thr Glu Leu Asp Leu Gln Leu Asn Asp Leu Gly Asp 
    690                 695                 700                 


Gly Gly Val Lys Met Leu Cys Glu Gly Leu Arg Asn Pro Ala Cys Asn 
705                 710                 715                 720 


Leu Ser Ile Leu Trp Leu Asp Gln Ala Ser Leu Ser Asp Gln Val Ile 
                725                 730                 735     


Ala Glu Leu Arg Thr Leu Glu Ala Lys Asn Pro Lys Leu Leu Ile Ser 
            740                 745                 750         


Ser Thr Trp Lys Pro His Val Met Val Pro Thr Met Asn Met Asp Lys 
        755                 760                 765             


Glu Glu Val Gly Asp Ser Gln Ala Leu Leu Lys Gln Gln Arg Gln Gln 
    770                 775                 780                 


Ser Gly Asp Lys His Met Glu Pro Leu Gly Thr Glu Asp Glu Phe Trp 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Val Thr Thr Glu Val Val Asp Arg Glu Arg Asn 
                805                 810                 815     


Leu Tyr Arg Val Gln Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser 
            820                 825                 830         


Thr Gly Leu His Phe Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu 
        835                 840                 845             


Phe Cys Ala Trp Ser Gln Tyr Leu Asp Lys Thr Pro Leu Gln Gln Ser 
    850                 855                 860                 


His Met Val Val Gly Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala 
865                 870                 875                 880 


Val Thr Ala Val Tyr Leu Pro His Phe Val Ala Leu Gln Glu Gly Ile 
                885                 890                 895     


Val Asp Ser Ser Leu Phe His Val Ala His Phe Gln Glu His Gly Met 
            900                 905                 910         


Val Leu Glu Thr Pro Ala Arg Val Glu Gln His Tyr Ala Val Leu Glu 
        915                 920                 925             


Asn Pro Ser Phe Ser Pro Met Gly Ile Leu Leu Arg Met Ile Pro Ala 
    930                 935                 940                 


Val Gly His Phe Ile Pro Ile Thr Ser Thr Thr Leu Ile Tyr Tyr His 
945                 950                 955                 960 


Leu Tyr Leu Glu Asp Val Thr Phe His Leu Tyr Leu Val Pro Asn Asp 
                965                 970                 975     


Cys Ser Ile Arg Lys Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe 
            980                 985                 990         


Val Arg Ile Asn Lys Pro Pro Pro  Val Asp Ala Leu Tyr  Leu Gly Ser 
        995                 1000                 1005             


Arg Tyr  Ile Val Ser Ser Ser  Lys Leu Val Glu Ile  Ile Pro Lys 
    1010                 1015                 1020             


Glu Leu  Glu Leu Cys Tyr Arg  Ser Pro Gly Glu Ser  Gln Leu Phe 
    1025                 1030                 1035             


Ser Glu  Ile Asp Ile Gly His  Met Asp Ser Glu Ile  Lys Leu Gln 
    1040                 1045                 1050             


Ile Lys  Asp Lys Arg His Met  Asn Leu Lys Trp Glu  Ala Leu Leu 
    1055                 1060                 1065             


Lys Pro  Gly Asp Leu Arg Pro  Ala Leu Pro Lys Ile  Ala Thr Ala 
    1070                 1075                 1080             


Pro Lys  Asp Ala Pro Ser Leu  Leu His Phe Met Asp  Gln His Arg 
    1085                 1090                 1095             


Glu Gln  Leu Val Ala Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp 
    1100                 1105                 1110             


Lys Leu  His Gly Leu Val Leu  Ser Glu Asp Ser Tyr  Glu Val Val 
    1115                 1120                 1125             


Arg Ser  Glu Thr Thr Asn Gln  Asp Lys Met Arg Lys  Leu Phe Ser 
    1130                 1135                 1140             


Leu Ser  Arg Ser Trp Ser Trp  Asp Cys Lys Asp Gln  Phe Tyr Gln 
    1145                 1150                 1155             


Ala Leu  Lys Glu Thr His Pro  His Leu Val Met Asp  Ile Leu Glu 
    1160                 1165                 1170             


Lys Leu  Gly Gly Val Ser Val  Lys Ser 
    1175                 1180         


<210>  21
<211>  906
<212>  PRT
<213>  Mus musculus

<400>  21

Met Glu Glu Ser Pro Pro Lys Gln Lys Ser Asn Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Gln Asp Leu Asn Thr Thr Arg His Met Asn Val Glu 
            20                  25                  30          


Leu Lys His Arg Pro Lys Leu Glu Arg His Leu Lys Leu Gly Met Ile 
        35                  40                  45              


Pro Val Val Tyr Met Lys Gln Arg Glu Glu Ile Leu Tyr Pro Ala Gln 
    50                  55                  60                  


Ser Leu Lys Glu Glu Asn Leu Ile Gln Asn Phe Thr Ser Leu Pro Leu 
65                  70                  75                  80  


Leu Gln Lys Leu Cys Pro Lys Asp Pro Glu Asn Met Val Arg Lys Ser 
                85                  90                  95      


Trp Ala Ser Cys Ile Pro Glu Glu Gly Gly His Met Ile Asn Ile Gln 
            100                 105                 110         


Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys Glu Pro Gln Leu Val 
        115                 120                 125             


Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser Thr Leu Ala Arg Leu 
    130                 135                 140                 


Val Lys Arg Ala Trp Lys Glu Gly Gln Leu Tyr Arg Asp His Phe Gln 
145                 150                 155                 160 


His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala Gln Cys Lys Lys Leu 
                165                 170                 175     


Ser Leu Ala Glu Leu Ile Ala Gln Gly Gln Glu Val Pro Thr Ala Pro 
            180                 185                 190         


Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu Leu Phe Ile Leu Asp 
        195                 200                 205             


Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp Gln Asn Pro Glu Leu 
    210                 215                 220                 


Cys Leu His Trp Ser Gln Arg Gln Pro Val His Thr Leu Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Gly Lys Ser Ile Leu Pro Glu Ala Phe Phe Leu Leu Thr Thr 
                245                 250                 255     


Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser Leu Pro Met Pro Cys 
            260                 265                 270         


Gln Val Glu Val Leu Gly Phe Ser Gly Ile Glu Trp Glu Asn Tyr Phe 
        275                 280                 285             


Tyr Lys Tyr Phe Ala Asn Gln Arg His Ala Ile Thr Ala Phe Met Met 
    290                 295                 300                 


Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys Glu Val Pro Trp Val 
305                 310                 315                 320 


Cys Trp Leu Val Cys Thr Cys Leu Lys Lys Gln Met Lys Gln Gly Arg 
                325                 330                 335     


Val Leu Ser Leu Lys Ser Gln Thr Thr Thr Ala Leu Cys Leu Lys Tyr 
            340                 345                 350         


Leu Ser Leu Thr Ile Pro Asp Lys His Arg Arg Thr Gln Val Lys Ala 
        355                 360                 365             


Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys Arg Arg Thr Leu Phe 
    370                 375                 380                 


Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp Glu Asp Ala Val Ala 
385                 390                 395                 400 


Thr Phe Leu Lys Thr Gly Val Leu Gln Lys Gln Ala Ser Ser Leu Ser 
                405                 410                 415     


Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe Phe Ala Ala Ile Ser 
            420                 425                 430         


Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly Asn Met Glu Met Asp 
        435                 440                 445             


Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly Arg Gln Asn Leu Phe 
    450                 455                 460                 


Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu Leu Gly Lys Glu Gly 
465                 470                 475                 480 


Val Lys Gly Met Glu Lys Leu Phe Ser Cys Ser Leu Pro Gly Lys Thr 
                485                 490                 495     


Lys Leu Lys Leu Leu Trp His Ile Leu Gly Lys Ser Gln Pro His Gln 
            500                 505                 510         


Pro Pro Cys Leu Gly Leu Leu His Cys Leu Tyr Glu Asn Gln Asp Met 
        515                 520                 525             


Glu Leu Leu Thr His Val Met His Asp Leu Gln Gly Thr Ile Val Pro 
    530                 535                 540                 


Gly Pro Asn Asp Ile Ala His Thr Val Leu Gln Thr Asn Val Lys Gln 
545                 550                 555                 560 


Leu Val Val Gln Thr Asp Met Glu Leu Met Val Ala Thr Phe Cys Ile 
                565                 570                 575     


Gln Phe Tyr Cys His Val Arg Thr Leu Gln Leu Asn Met Glu Lys Gln 
            580                 585                 590         


Gln Gly Tyr Ala Leu Thr Ser Pro Arg Met Val Leu Tyr Arg Trp Thr 
        595                 600                 605             


Pro Ile Thr Asn Ala Ser Trp Glu Ile Leu Phe Tyr Asn Leu Lys Phe 
    610                 615                 620                 


Thr Arg Asn Leu Glu Gly Leu Asp Leu Ser Gly Asn Ser Leu Arg Tyr 
625                 630                 635                 640 


Ser Val Val Gln Ser Leu Cys Asn Thr Leu Arg Tyr Pro Gly Cys Gln 
                645                 650                 655     


Leu Lys Thr Leu Trp Leu Val Lys Cys Gly Leu Thr Ser Arg Tyr Cys 
            660                 665                 670         


Ser Leu Leu Ala Ser Val Leu Ser Ala His Ser Ser Leu Thr Glu Leu 
        675                 680                 685             


Tyr Leu Gln Leu Asn Asp Leu Gly Asp Asp Gly Val Arg Met Leu Cys 
    690                 695                 700                 


Glu Gly Leu Arg Asn Pro Val Cys Asn Leu Ser Ile Leu Trp Leu Asp 
705                 710                 715                 720 


Leu Ser Ser Leu Ser Ala Gln Val Ile Thr Glu Leu Arg Thr Leu Glu 
                725                 730                 735     


Glu Lys Asn Pro Lys Leu Tyr Ile Arg Ser Ile Trp Met Pro His Met 
            740                 745                 750         


Met Val Pro Thr Glu Asn Met Asp Glu Glu Ala Ile Leu Thr Thr Phe 
        755                 760                 765             


Lys Gln Gln Arg Gln Glu Ser Gly Asp Lys Pro Met Glu Ile Leu Gly 
    770                 775                 780                 


Thr Glu Glu Asp Phe Trp Gly Pro Thr Gly Pro Val Ala Thr Glu Leu 
785                 790                 795                 800 


Val Asp Arg Val Arg Asn Leu Tyr Arg Val Gln Leu Pro Met Ala Gly 
                805                 810                 815     


Ser Tyr His Cys Pro Ser Thr Gly Leu His Phe Val Val Thr Arg Ala 
            820                 825                 830         


Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser Gln Phe Leu Asp Lys 
        835                 840                 845             


Thr Pro Leu Gln Gln Ser His Met Val Val Gly Pro Leu Phe Asp Ile 
    850                 855                 860                 


Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr Leu Pro His Phe Val 
865                 870                 875                 880 


Ser Leu Lys Asp Thr Glu Ala Ser Thr Phe Asp Phe Lys Val Thr His 
                885                 890                 895     


Phe Gln Glu His Gly Ser Arg Asn Ala Arg 
            900                 905     


<210>  22
<211>  1172
<212>  PRT
<213>  Mus musculus

<400>  22

Met Glu Glu Ser Pro Pro Lys Gln Lys Ser Asn Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Gln Asp Leu Asn Thr Thr Arg His Met Asn Val Glu 
            20                  25                  30          


Leu Lys His Arg Pro Lys Leu Glu Arg His Leu Lys Leu Gly Met Ile 
        35                  40                  45              


Pro Val Val Tyr Met Lys Gln Arg Glu Glu Ile Leu Tyr Pro Ala Gln 
    50                  55                  60                  


Ser Leu Lys Glu Glu Asn Leu Ile Gln Asn Phe Thr Ser Leu Pro Leu 
65                  70                  75                  80  


Leu Gln Lys Leu Tyr Pro Lys Asp Pro Glu Asn Met Val Arg Lys Ser 
                85                  90                  95      


Trp Ala Ser Cys Ile Pro Glu Glu Gly Gly His Met Ile Asn Ile Gln 
            100                 105                 110         


Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys Glu Pro Gln Leu Val 
        115                 120                 125             


Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser Thr Leu Ala Arg Leu 
    130                 135                 140                 


Val Lys Arg Ala Trp Lys Glu Gly Gln Leu Tyr Arg Asp His Phe Gln 
145                 150                 155                 160 


His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala Gln Cys Lys Lys Leu 
                165                 170                 175     


Ser Leu Ala Glu Leu Ile Ala Gln Gly Gln Glu Val Pro Thr Ala Pro 
            180                 185                 190         


Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu Leu Phe Ile Leu Asp 
        195                 200                 205             


Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp Gln Asn Pro Glu Leu 
    210                 215                 220                 


Cys Leu His Trp Ser Gln Arg Gln Pro Val His Thr Leu Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Gly Lys Ser Ile Leu Pro Glu Ala Phe Phe Leu Leu Thr Thr 
                245                 250                 255     


Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser Leu Pro Met Pro Cys 
            260                 265                 270         


Gln Val Glu Val Leu Gly Phe Ser Gly Ile Glu Arg Glu Asn Tyr Phe 
        275                 280                 285             


Tyr Lys Tyr Phe Ala Asn Gln Arg His Ala Ile Thr Ala Phe Met Met 
    290                 295                 300                 


Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys Glu Val Pro Trp Val 
305                 310                 315                 320 


Cys Trp Leu Val Cys Thr Cys Leu Lys Lys Gln Met Glu Gln Gly Arg 
                325                 330                 335     


Val Leu Ser Leu Lys Ser Gln Thr Thr Thr Ala Leu Cys Leu Lys Tyr 
            340                 345                 350         


Pro Ser Leu Thr Ile Pro Asp Lys His Arg Arg Thr Gln Val Lys Ala 
        355                 360                 365             


Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys Arg Arg Thr Leu Phe 
    370                 375                 380                 


Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp Glu Asp Ala Val Ala 
385                 390                 395                 400 


Thr Phe Leu Lys Thr Gly Val Leu Gln Lys Gln Ala Ser Ser Leu Ser 
                405                 410                 415     


Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe Phe Ala Ala Ile Ser 
            420                 425                 430         


Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly Asn Met Glu Met Asp 
        435                 440                 445             


Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly Arg Gln Asn Leu Phe 
    450                 455                 460                 


Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu Leu Gly Lys Glu Gly 
465                 470                 475                 480 


Val Lys Gly Met Glu Lys Leu Phe Ser Cys Ser Leu His Gly Lys Thr 
                485                 490                 495     


Lys Leu Lys Leu Leu Trp His Ile Leu Gly Lys Ser Gln Pro His Gln 
            500                 505                 510         


Pro Ser Cys Leu Gly Leu Leu His Cys Leu Tyr Glu Asn Gln Asp Met 
        515                 520                 525             


Glu Leu Leu Thr His Val Met His Asp Leu Gln Gly Thr Ile Val Pro 
    530                 535                 540                 


Gly Pro Asn Asp Ile Ala His Thr Val Leu Gln Thr Asn Val Lys Gln 
545                 550                 555                 560 


Leu Val Val Gln Thr Asp Met Glu Leu Met Val Ala Thr Phe Cys Ile 
                565                 570                 575     


Gln Phe Tyr Cys His Val Arg Thr Leu Gln Leu Asn Met Glu Lys Gln 
            580                 585                 590         


Gln Gly Tyr Ala Leu Thr Ser Pro Arg Met Val Leu Tyr Arg Trp Thr 
        595                 600                 605             


Pro Ile Thr Asn Ala Ser Trp Glu Ile Leu Phe Tyr Asn Leu Lys Phe 
    610                 615                 620                 


Thr Arg Asn Leu Glu Gly Leu Asp Leu Ser Gly Asn Ser Leu Arg Tyr 
625                 630                 635                 640 


Ser Val Val Gln Ser Leu Cys Asn Thr Leu Arg Tyr Pro Gly Cys Gln 
                645                 650                 655     


Leu Lys Thr Leu Trp Leu Val Lys Cys Gly Leu Thr Ser Arg Tyr Cys 
            660                 665                 670         


Ser Leu Leu Ala Ser Val Leu Ser Ala His Ser Ser Leu Thr Glu Leu 
        675                 680                 685             


Tyr Leu Gln Leu Asn Asp Leu Gly Asp Asp Gly Val Arg Met Leu Cys 
    690                 695                 700                 


Glu Gly Leu Arg Asn Pro Val Cys Asn Leu Ser Ile Leu Trp Leu Asp 
705                 710                 715                 720 


Leu Ser Ser Leu Ser Ala Gln Val Ile Thr Glu Leu Arg Thr Leu Glu 
                725                 730                 735     


Glu Lys Asn Pro Lys Leu Tyr Ile Arg Ser Ile Trp Met Pro His Met 
            740                 745                 750         


Met Val Pro Thr Glu Asn Met Asp Glu Glu Ala Ile Leu Thr Thr Phe 
        755                 760                 765             


Lys Gln Gln Arg Gln Glu Ser Gly Asp Lys Pro Met Glu Ile Leu Gly 
    770                 775                 780                 


Thr Glu Glu Asp Phe Trp Gly Pro Thr Gly Pro Val Ala Thr Glu Leu 
785                 790                 795                 800 


Val Asp Arg Val Arg Asn Leu Tyr Arg Val Gln Leu Pro Met Ala Gly 
                805                 810                 815     


Ser Tyr His Cys Pro Ser Thr Gly Leu His Phe Val Val Thr Arg Ala 
            820                 825                 830         


Val Thr Ile Glu Ile Glu Phe Cys Ala Trp Ser Gln Phe Leu Asp Lys 
        835                 840                 845             


Thr Pro Leu Gln Gln Ser His Met Val Val Gly Pro Leu Phe Asp Ile 
    850                 855                 860                 


Lys Ala Glu Gln Gly Ala Val Thr Ala Val Tyr Leu Pro His Phe Val 
865                 870                 875                 880 


Ser Leu Lys Asp Thr Glu Ala Ser Thr Phe Asp Phe Lys Val Ala His 
                885                 890                 895     


Phe Gln Glu His Gly Ile Val Leu Glu Thr Pro Asp Arg Val Lys Pro 
            900                 905                 910         


Gly Tyr Thr Val Leu Lys Asn Pro Ser Phe Ser Pro Met Gly Asp Val 
        915                 920                 925             


Leu Arg Ile Ile Pro Ala Asp Arg His Phe Ile Pro Ile Thr Ser Ile 
    930                 935                 940                 


Thr Leu Ile Tyr Tyr Arg Leu Asn Leu Glu Glu Val Thr Leu His Leu 
945                 950                 955                 960 


Tyr Leu Val Pro Ser Asp Cys Thr Ile Gln Lys Ala Ile Asp Asp Glu 
                965                 970                 975     


Glu Met Lys Phe Gln Phe Val Arg Ile Asn Lys Pro Pro Pro Val Asp 
            980                 985                 990         


Asn Leu Phe Ile Gly Ser Arg Tyr  Ile Val Ser Gly Ser  Glu Asn Leu 
        995                 1000                 1005             


Glu Ile  Thr Pro Lys Glu Leu  Glu Leu Cys Tyr Arg  Ser Ser Lys 
    1010                 1015                 1020             


Glu Phe  Gln Leu Phe Ser Glu  Ile Tyr Val Gly Asn  Met Gly Ser 
    1025                 1030                 1035             


Glu Ile  Lys Leu Gln Ile Lys  Asn Lys Lys His Met  Arg Leu Ile 
    1040                 1045                 1050             


Trp Glu  Ala Leu Leu Lys Pro  Gly Asp Leu Arg Pro  Ala Leu Pro 
    1055                 1060                 1065             


Arg Ile  Ala Gln Ala Leu Lys  Asp Ala Pro Ser Leu  Leu His Phe 
    1070                 1075                 1080             


Met Asp  Gln His Arg Glu Gln  Leu Val Ala Arg Val  Thr Ser Val 
    1085                 1090                 1095             


Asp Pro  Leu Leu Asp Lys Leu  His Gly Leu Val Leu  Asn Glu Glu 
    1100                 1105                 1110             


Ser Tyr  Glu Ala Val Arg Ala  Glu Asn Thr Asn Gln  Asp Lys Met 
    1115                 1120                 1125             


Arg Lys  Leu Phe Asn Leu Ser  Arg Ser Trp Ser Arg  Ala Cys Lys 
    1130                 1135                 1140             


Asp Leu  Phe Tyr Gln Ala Leu  Lys Glu Thr His Pro  His Leu Val 
    1145                 1150                 1155             


Met Asp  Leu Leu Glu Lys Ser  Gly Gly Val Ser Leu  Gly Ser 
    1160                 1165                 1170         


<210>  23
<211>  1233
<212>  PRT
<213>  Mus musculus

<400>  23

Met Glu Glu Ser Pro Pro Lys Gln Lys Ser Asn Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Gln Asp Leu Asn Thr Thr Arg His Met Asn Val Glu 
            20                  25                  30          


Leu Lys His Arg Pro Lys Leu Glu Arg His Leu Lys Leu Gly Met Ile 
        35                  40                  45              


Pro Val Val Tyr Met Lys Gln Gly Glu Glu Ile Leu Tyr Pro Ala Gln 
    50                  55                  60                  


Ser Leu Arg Glu Glu Asn Leu Ile Gln Asn Phe Thr Ser Leu Leu Leu 
65                  70                  75                  80  


Leu Gln Lys Leu Cys Pro Lys Asp Pro Glu Asn Met Ile Arg Lys Ser 
                85                  90                  95      


Trp Ala Ser Cys Val Pro Glu Glu Gly Gly His Met Ile Asn Ile Gln 
            100                 105                 110         


Asp Leu Phe Gly Pro Asn Ile Gly Thr Gln Lys Glu Pro Gln Leu Val 
        115                 120                 125             


Ile Ile Glu Gly Ala Ala Gly Ile Gly Lys Ser Thr Leu Ala Arg Leu 
    130                 135                 140                 


Val Lys Arg Ala Trp Lys Glu Gly Gln Leu Tyr Arg Asp His Phe Gln 
145                 150                 155                 160 


His Val Phe Phe Phe Ser Cys Arg Glu Leu Ala Gln Cys Lys Lys Leu 
                165                 170                 175     


Ser Leu Ala Glu Leu Ile Ala Gln Gly Gln Glu Val Pro Thr Ala Pro 
            180                 185                 190         


Ile Asn Gln Ile Leu Ser His Pro Glu Lys Leu Leu Phe Ile Leu Asp 
        195                 200                 205             


Gly Ile Asp Glu Pro Ala Trp Val Leu Ala Asp Gln Asn Pro Glu Leu 
    210                 215                 220                 


Cys Leu His Trp Ser Gln Arg Gln Pro Val His Thr Leu Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Gly Lys Ser Ile Leu Pro Glu Ala Phe Phe Leu Leu Thr Thr 
                245                 250                 255     


Arg Thr Thr Ala Leu Gln Lys Phe Ile Pro Ser Leu Pro Met Pro Cys 
            260                 265                 270         


Gln Val Glu Val Leu Gly Phe Ser Gly Ile Glu Arg Glu Asn Tyr Phe 
        275                 280                 285             


Tyr Lys Tyr Phe Ala Asn Gln Arg His Ala Ile Thr Ala Phe Met Met 
    290                 295                 300                 


Val Glu Ser Asn Pro Val Leu Leu Thr Leu Cys Glu Val Pro Trp Val 
305                 310                 315                 320 


Cys Trp Leu Val Cys Thr Cys Leu Lys Lys Gln Met Glu Gln Gly Arg 
                325                 330                 335     


Val Leu Ser Leu Lys Ser Gln Thr Thr Thr Ala Leu Cys Leu Lys Tyr 
            340                 345                 350         


Leu Ser Leu Thr Ile Pro Asp Lys His Arg Arg Thr Gln Val Lys Ala 
        355                 360                 365             


Leu Cys Ser Leu Ala Ala Glu Gly Ile Trp Lys Arg Arg Thr Leu Phe 
    370                 375                 380                 


Ser Glu Ser Asp Leu Cys Lys Gln Gly Leu Asp Glu Asp Ala Val Ala 
385                 390                 395                 400 


Thr Phe Leu Lys Thr Gly Val Leu Gln Lys Gln Ala Ser Ser Leu Ser 
                405                 410                 415     


Tyr Ser Phe Ala His Leu Cys Leu Gln Glu Phe Phe Ala Ala Ile Ser 
            420                 425                 430         


Cys Ile Leu Glu Asp Ser Glu Glu Arg His Gly Asn Met Glu Met Asp 
        435                 440                 445             


Arg Ile Val Glu Thr Leu Val Glu Arg Tyr Gly Arg Gln Asn Leu Phe 
    450                 455                 460                 


Glu Ala Pro Thr Val Arg Phe Leu Phe Gly Leu Leu Gly Lys Glu Gly 
465                 470                 475                 480 


Val Lys Gly Met Glu Lys Leu Phe Ser Cys Ser Leu His Gly Lys Thr 
                485                 490                 495     


Asn Leu Lys Leu Leu Trp His Ile Leu Val Lys Ser Gln Pro His Gln 
            500                 505                 510         


Pro Pro Cys Leu Gly Leu Leu His Cys Leu Tyr Glu Asn Gln Asp Met 
        515                 520                 525             


Glu Leu Leu Thr His Val Met His Asp Leu Gln Gly Thr Ile Val Pro 
    530                 535                 540                 


Gly Pro Asn Asp Thr Ala His Thr Val Leu Gln Thr Asn Val Lys His 
545                 550                 555                 560 


Leu Val Val Gln Thr Asp Met Glu Leu Met Val Ala Thr Phe Cys Ile 
                565                 570                 575     


Gln Phe Tyr Cys His Val Arg Thr Leu Gln Leu Asn Met Glu Lys Gln 
            580                 585                 590         


Gln Gly Tyr Ala Leu Ile Ser Pro Arg Met Val Leu Tyr Arg Trp Thr 
        595                 600                 605             


Pro Ile Thr Asn Ala Ser Trp Glu Ile Leu Phe Tyr Asn Leu Lys Phe 
    610                 615                 620                 


Thr Arg Asn Leu Glu Gly Leu Asp Leu Ser Gly Asn Ser Leu Arg Tyr 
625                 630                 635                 640 


Ser Val Val Gln Ser Leu Cys Asn Thr Leu Arg Tyr Pro Gly Cys Gln 
                645                 650                 655     


Leu Lys Thr Leu Trp Leu Val Lys Cys Gly Leu Thr Ser Arg Tyr Cys 
            660                 665                 670         


Ser Leu Leu Ala Ser Val Leu Ser Ala His Ser Ser Leu Thr Glu Leu 
        675                 680                 685             


Tyr Leu Gln Leu Asn Asp Leu Gly Asp Asp Gly Val Arg Met Leu Cys 
    690                 695                 700                 


Glu Gly Leu Arg Asn Pro Val Cys Asn Leu Ser Ile Leu Trp Leu Asp 
705                 710                 715                 720 


Leu Ser Ser Leu Ser Ala Gln Val Ile Thr Glu Leu Arg Thr Leu Glu 
                725                 730                 735     


Glu Lys Asn Pro Lys Leu Tyr Ile Arg Ser Ile Trp Met Pro His Met 
            740                 745                 750         


Met Val Pro Thr Glu Asn Met Asp Glu Glu Ala Ile Leu Thr Thr Leu 
        755                 760                 765             


Lys Gln Gln Arg Gln Glu Ser Gly Asp Lys Pro Met Glu Ile Leu Gly 
    770                 775                 780                 


Thr Glu Glu Asp Phe Trp Gly Pro Thr Gly Pro Val Ala Thr Glu Leu 
785                 790                 795                 800 


Val Asp Arg Val Arg Asn Leu Tyr Arg Met Pro Gln Met Met Val Pro 
                805                 810                 815     


Thr Glu Asn Met Asp Glu Glu Asp Ile Leu Thr Ser Phe Lys Gln Gln 
            820                 825                 830         


Arg Gln Gln Ser Gly Ala Asn Pro Met Glu Ile Leu Gly Thr Glu Glu 
        835                 840                 845             


Asp Phe Trp Gly Pro Ile Gly Pro Val Ala Thr Glu Val Val Tyr Arg 
    850                 855                 860                 


Glu Arg Asn Leu Tyr Arg Val Gln Leu Pro Met Ala Gly Ser Tyr His 
865                 870                 875                 880 


Cys Pro Ser Thr Arg Leu His Phe Val Val Thr Arg Ala Val Thr Ile 
                885                 890                 895     


Glu Ile Glu Phe Cys Ala Trp Ser Gln Phe Leu Asp Lys Thr Pro Leu 
            900                 905                 910         


Gln Gln Ser His Met Val Val Gly Pro Leu Phe Asp Ile Lys Ala Glu 
        915                 920                 925             


Gln Gly Ala Val Thr Ala Val Tyr Leu Pro His Phe Val Ser Leu Lys 
    930                 935                 940                 


Asp Thr Lys Ala Ser Thr Phe Asp Phe Lys Val Ala His Phe Gln Glu 
945                 950                 955                 960 


His Gly Met Val Leu Glu Thr Pro Asp Arg Val Lys Pro Gly Tyr Thr 
                965                 970                 975     


Val Leu Lys Asn Pro Ser Phe Ser Pro Met Gly Val Val Leu Arg Ile 
            980                 985                 990         


Ile Pro Ala Ala Arg His Phe Ile  Pro Ile Thr Ser Ile  Thr Leu Ile 
        995                 1000                 1005             


Tyr Tyr  Arg Val Asn Gln Glu  Glu Val Thr Leu His  Leu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Asn Asp Cys Thr Ile  Gln Lys Ala Ile Asp  Asp Glu Glu 
    1025                 1030                 1035             


Met Lys  Phe Gln Phe Val Arg  Ile Asn Lys Pro Pro  Pro Val Asp 
    1040                 1045                 1050             


Asn Leu  Phe Ile Gly Ser Arg  Tyr Ile Val Ser Gly  Ser Glu Asn 
    1055                 1060                 1065             


Leu Glu  Ile Thr Pro Lys Glu  Leu Glu Leu Cys Tyr  Arg Ser Ser 
    1070                 1075                 1080             


Lys Glu  Phe Gln Leu Phe Ser  Glu Ile Tyr Val Gly  Asn Met Gly 
    1085                 1090                 1095             


Ser Glu  Ile Lys Leu Gln Ile  Lys Asn Lys Lys His  Met Lys Leu 
    1100                 1105                 1110             


Ile Trp  Glu Ala Leu Leu Lys  Pro Gly Asp Leu Arg  Pro Ala Leu 
    1115                 1120                 1125             


Pro Arg  Ile Ala Gln Ala Leu  Lys Asp Ala Pro Ser  Leu Leu His 
    1130                 1135                 1140             


Phe Met  Asp Gln His Arg Glu  Gln Leu Val Ala Arg  Val Thr Ser 
    1145                 1150                 1155             


Val Asp  Pro Leu Leu Asp Lys  Leu His Gly Leu Val  Leu Asn Glu 
    1160                 1165                 1170             


Glu Ser  Tyr Glu Ala Val Arg  Ala Glu Asn Thr Asn  Gln Asp Lys 
    1175                 1180                 1185             


Met Arg  Lys Leu Phe Asn Leu  Ser Arg Ser Trp Ser  Arg Ala Cys 
    1190                 1195                 1200             


Lys Asp  Leu Phe Tyr Gln Ala  Leu Lys Glu Thr His  Pro His Leu 
    1205                 1210                 1215             


Val Met  Asp Leu Leu Glu Lys  Ser Gly Gly Val Ser  Leu Gly Ser 
    1220                 1225                 1230             


<210>  24
<211>  3957
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Asp Glu Thr Glu  Ser Thr Glu Thr Ser  Val Leu Lys 
    1475                 1480                 1485             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1490                 1495                 1500             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Thr 
    1505                 1510                 1515             


Ala Ile  Leu Thr Thr Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1520                 1525                 1530             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1535                 1540                 1545             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1550                 1555                 1560             


Glu Ile  Leu Arg Ser Gly Thr  Cys Thr Arg Asp Glu  Ser Ser Val 
    1565                 1570                 1575             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1580                 1585                 1590             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1595                 1600                 1605             


Leu Glu  Ile Thr Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1610                 1615                 1620             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Thr Gly  Leu Val Asn 
    1625                 1630                 1635             


Tyr Leu  Thr Asp Asp Leu Asn  Thr Cys Val Pro Leu  Pro Lys Glu 
    1640                 1645                 1650             


Gln Leu  Gln Thr Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1655                 1660                 1665             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1670                 1675                 1680             


Pro Asp  Glu Thr Gln Ser Thr  Gln Lys Gln His Lys  Pro Ser Leu 
    1685                 1690                 1695             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1700                 1705                 1710             


Gln Lys  Glu Glu Gly Leu Gln  Ala Ser Ala Glu Lys  Ala Glu Leu 
    1715                 1720                 1725             


Lys Lys  Gly Ser Ser Glu Glu  Ser Leu Gly Glu Asp  Pro Gly Leu 
    1730                 1735                 1740             


Ala Pro  Glu Pro Leu Pro Thr  Val Lys Ala Thr Ser  Pro Leu Ile 
    1745                 1750                 1755             


Glu Glu  Thr Pro Ile Gly Ser  Ile Lys Asp Lys Val  Lys Ala Leu 
    1760                 1765                 1770             


Gln Lys  Arg Val Glu Asp Glu  Gln Lys Gly Arg Ser  Lys Leu Pro 
    1775                 1780                 1785             


Ile Arg  Val Lys Gly Lys Glu  Asp Val Pro Lys Lys  Thr Thr His 
    1790                 1795                 1800             


Arg Pro  His Pro Ala Ala Ser  Pro Ser Leu Lys Ser  Glu Arg His 
    1805                 1810                 1815             


Ala Pro  Gly Ser Pro Ser Pro  Lys Thr Glu Arg His  Ser Thr Leu 
    1820                 1825                 1830             


Ser Ser  Ser Ala Lys Thr Glu  Arg His Pro Pro Val  Ser Pro Ser 
    1835                 1840                 1845             


Ser Lys  Thr Glu Lys His Ser  Pro Val Ser Pro Ser  Ala Lys Thr 
    1850                 1855                 1860             


Glu Arg  His Ser Pro Ala Ser  Ser Ser Ser Lys Thr  Glu Lys His 
    1865                 1870                 1875             


Ser Pro  Val Ser Pro Ser Thr  Lys Thr Glu Arg His  Ser Pro Val 
    1880                 1885                 1890             


Ser Ser  Thr Lys Thr Glu Arg  His Pro Pro Val Ser  Pro Ser Gly 
    1895                 1900                 1905             


Lys Thr  Asp Lys Arg Pro Pro  Val Ser Pro Ser Gly  Arg Thr Glu 
    1910                 1915                 1920             


Lys His  Pro Pro Val Ser Pro  Gly Arg Thr Glu Lys  Arg Leu Pro 
    1925                 1930                 1935             


Val Ser  Pro Ser Gly Arg Thr  Asp Lys His Gln Pro  Val Ser Thr 
    1940                 1945                 1950             


Ala Gly  Lys Thr Glu Lys His  Leu Pro Val Ser Pro  Ser Gly Lys 
    1955                 1960                 1965             


Thr Glu  Lys Gln Pro Pro Val  Ser Pro Thr Ser Lys  Thr Glu Arg 
    1970                 1975                 1980             


Ile Glu  Glu Thr Met Ser Val  Arg Glu Leu Met Lys  Ala Phe Gln 
    1985                 1990                 1995             


Ser Gly  Gln Asp Pro Ser Lys  His Lys Thr Gly Leu  Phe Glu His 
    2000                 2005                 2010             


Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Glu Lys Gly  Lys Val Arg 
    2015                 2020                 2025             


Val Glu  Lys Glu Lys Gly Pro  Ile Leu Thr Gln Arg  Glu Ala Gln 
    2030                 2035                 2040             


Lys Thr  Glu Asn Gln Thr Ile  Lys Arg Gly Gln Arg  Leu Pro Val 
    2045                 2050                 2055             


Thr Gly  Thr Ala Glu Ser Lys  Arg Gly Val Arg Val  Ser Ser Ile 
    2060                 2065                 2070             


Gly Val  Lys Lys Glu Asp Ala  Ala Gly Gly Lys Glu  Lys Val Leu 
    2075                 2080                 2085             


Ser His  Lys Ile Pro Glu Pro  Val Gln Ser Val Pro  Glu Glu Glu 
    2090                 2095                 2100             


Ser His  Arg Glu Ser Glu Val  Pro Lys Glu Lys Met  Ala Asp Glu 
    2105                 2110                 2115             


Gln Gly  Asp Met Asp Leu Gln  Ile Ser Pro Asp Arg  Lys Thr Ser 
    2120                 2125                 2130             


Thr Asp  Phe Ser Glu Val Ile  Lys Gln Glu Leu Glu  Asp Asn Asp 
    2135                 2140                 2145             


Lys Tyr  Gln Gln Phe Arg Leu  Ser Glu Glu Thr Glu  Lys Ala Gln 
    2150                 2155                 2160             


Leu His  Leu Asp Gln Val Leu  Thr Ser Pro Phe Asn  Thr Thr Phe 
    2165                 2170                 2175             


Pro Leu  Asp Tyr Met Lys Asp  Glu Phe Leu Pro Ala  Leu Ser Leu 
    2180                 2185                 2190             


Gln Ser  Gly Ala Leu Asp Gly  Ser Ser Glu Ser Leu  Lys Asn Glu 
    2195                 2200                 2205             


Gly Val  Ala Gly Ser Pro Cys  Gly Ser Leu Met Glu  Gly Thr Pro 
    2210                 2215                 2220             


Gln Ile  Ser Ser Glu Glu Ser  Tyr Lys His Glu Gly  Leu Ala Glu 
    2225                 2230                 2235             


Thr Pro  Glu Thr Ser Pro Glu  Ser Leu Ser Phe Ser  Pro Lys Lys 
    2240                 2245                 2250             


Ser Glu  Glu Gln Thr Gly Glu  Thr Lys Glu Ser Thr  Lys Thr Glu 
    2255                 2260                 2265             


Thr Thr  Thr Glu Ile Arg Ser  Glu Lys Glu His Pro  Thr Thr Lys 
    2270                 2275                 2280             


Asp Ile  Thr Gly Gly Ser Glu  Glu Arg Gly Ala Thr  Val Thr Glu 
    2285                 2290                 2295             


Asp Ser  Glu Thr Ser Thr Glu  Ser Phe Gln Lys Glu  Ala Thr Leu 
    2300                 2305                 2310             


Gly Ser  Pro Lys Asp Thr Ser  Pro Lys Arg Gln Asp  Asp Cys Thr 
    2315                 2320                 2325             


Gly Ser  Cys Ser Val Ala Leu  Ala Lys Glu Thr Pro  Thr Gly Leu 
    2330                 2335                 2340             


Thr Glu  Glu Ala Ala Cys Asp  Glu Gly Gln Arg Thr  Phe Gly Ser 
    2345                 2350                 2355             


Ser Ala  His Lys Thr Gln Thr  Asp Ser Glu Val Gln  Glu Ser Thr 
    2360                 2365                 2370             


Ala Thr  Ser Asp Glu Thr Lys  Ala Leu Pro Leu Pro  Glu Ala Ser 
    2375                 2380                 2385             


Val Lys  Thr Asp Thr Gly Thr  Glu Ser Lys Pro Gln  Gly Val Ile 
    2390                 2395                 2400             


Arg Ser  Pro Gln Gly Leu Glu  Leu Ala Leu Pro Ser  Arg Asp Ser 
    2405                 2410                 2415             


Glu Val  Leu Ser Ala Val Ala  Asp Asp Ser Leu Ala  Val Ser His 
    2420                 2425                 2430             


Lys Asp  Ser Leu Glu Ala Ser  Pro Val Leu Glu Asp  Asn Ser Ser 
    2435                 2440                 2445             


His Lys  Thr Pro Asp Ser Leu  Glu Pro Ser Pro Leu  Lys Glu Ser 
    2450                 2455                 2460             


Pro Cys  Arg Asp Ser Leu Glu  Ser Ser Pro Val Glu  Pro Lys Met 
    2465                 2470                 2475             


Lys Ala  Gly Ile Phe Pro Ser  His Phe Pro Leu Pro  Ala Ala Val 
    2480                 2485                 2490             


Ala Lys  Thr Glu Leu Leu Thr  Glu Val Ala Ser Val  Arg Ser Arg 
    2495                 2500                 2505             


Leu Leu  Arg Asp Pro Asp Gly  Ser Ala Glu Asp Asp  Ser Leu Glu 
    2510                 2515                 2520             


Gln Thr  Ser Leu Met Glu Ser  Ser Gly Lys Ser Pro  Leu Ser Pro 
    2525                 2530                 2535             


Asp Thr  Pro Ser Ser Glu Glu  Val Ser Tyr Glu Val  Thr Pro Lys 
    2540                 2545                 2550             


Thr Thr  Asp Val Ser Thr Pro  Lys Pro Ala Val Ile  His Glu Cys 
    2555                 2560                 2565             


Ala Glu  Glu Asp Asp Ser Glu  Asn Gly Glu Lys Lys  Arg Phe Thr 
    2570                 2575                 2580             


Pro Glu  Glu Glu Met Phe Lys  Met Val Thr Lys Ile  Lys Met Phe 
    2585                 2590                 2595             


Asp Glu  Leu Glu Gln Glu Ala  Lys Gln Lys Arg Asp  Tyr Lys Lys 
    2600                 2605                 2610             


Glu Pro  Lys Gln Glu Glu Ser  Ser Ser Ser Ser Asp  Pro Asp Ala 
    2615                 2620                 2625             


Asp Cys  Ser Val Asp Val Asp  Glu Pro Lys His Thr  Gly Ser Gly 
    2630                 2635                 2640             


Glu Asp  Glu Ser Gly Val Pro  Val Leu Val Thr Ser  Glu Ser Arg 
    2645                 2650                 2655             


Lys Val  Ser Ser Ser Ser Glu  Ser Glu Pro Glu Leu  Ala Gln Leu 
    2660                 2665                 2670             


Lys Lys  Gly Ala Asp Ser Gly  Leu Leu Pro Glu Pro  Val Ile Arg 
    2675                 2680                 2685             


Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser Met Asp  Ser Asn Ser 
    2690                 2695                 2700             


Ser Pro  Glu Glu Val Gln Phe  Gln Pro Val Val Ser  Lys Gln Tyr 
    2705                 2710                 2715             


Thr Phe  Lys Met Asn Glu Asp  Thr Gln Glu Glu Pro  Gly Lys Ser 
    2720                 2725                 2730             


Glu Glu  Glu Lys Asp Ser Glu  Ser His Leu Ala Glu  Asp Arg His 
    2735                 2740                 2745             


Ala Val  Ser Thr Glu Ala Glu  Asp Arg Ser Tyr Asp  Lys Leu Asn 
    2750                 2755                 2760             


Arg Asp  Thr Asp Gln Pro Lys  Ile Cys Asp Gly His  Gly Cys Glu 
    2765                 2770                 2775             


Ala Met  Ser Pro Ser Ser Ser  Ala Ala Pro Val Ser  Ser Gly Leu 
    2780                 2785                 2790             


Gln Ser  Pro Thr Gly Asp Asp  Val Asp Glu Gln Pro  Val Ile Tyr 
    2795                 2800                 2805             


Lys Glu  Ser Leu Ala Leu Gln  Gly Thr His Glu Lys  Asp Thr Glu 
    2810                 2815                 2820             


Gly Glu  Glu Leu Asp Val Ser  Arg Ala Glu Ser Pro  Gln Ala Asp 
    2825                 2830                 2835             


Cys Pro  Ser Glu Ser Phe Ser  Ser Ser Ser Ser Leu  Pro His Cys 
    2840                 2845                 2850             


Leu Val  Ser Glu Gly Lys Glu  Leu Asp Glu Asp Ile  Ser Ala Thr 
    2855                 2860                 2865             


Ser Ser  Ile Gln Lys Thr Glu  Val Thr Lys Thr Asp  Glu Thr Phe 
    2870                 2875                 2880             


Glu Asn  Leu Pro Lys Asp Cys  Pro Ser Gln Asp Ser  Ser Ile Thr 
    2885                 2890                 2895             


Thr Gln  Thr Asp Arg Phe Ser  Met Asp Val Pro Val  Ser Asp Leu 
    2900                 2905                 2910             


Ala Glu  Asn Asp Glu Ile Tyr  Asp Pro Gln Ile Thr  Ser Pro Tyr 
    2915                 2920                 2925             


Glu Asn  Val Pro Ser Gln Ser  Phe Phe Ser Ser Glu  Glu Ser Lys 
    2930                 2935                 2940             


Thr Gln  Thr Asp Ala Asn His  Thr Thr Ser Phe His  Ser Ser Glu 
    2945                 2950                 2955             


Val Tyr  Ser Val Thr Ile Thr  Ser Pro Val Glu Asp  Val Val Val 
    2960                 2965                 2970             


Ala Ser  Ser Ser Ser Gly Thr  Val Leu Ser Lys Glu  Ser Asn Phe 
    2975                 2980                 2985             


Glu Gly  Gln Asp Ile Lys Met  Glu Ser Gln Gln Glu  Ser Thr Leu 
    2990                 2995                 3000             


Trp Glu  Met Gln Ser Asp Ser  Val Ser Ser Ser Phe  Glu Pro Thr 
    3005                 3010                 3015             


Met Ser  Ala Thr Thr Thr Val  Val Gly Glu Gln Ile  Ser Lys Val 
    3020                 3025                 3030             


Ile Ile  Thr Lys Thr Asp Val  Asp Ser Asp Ser Trp  Ser Glu Ile 
    3035                 3040                 3045             


Arg Glu  Asp Asp Glu Ala Phe  Glu Ala Arg Val Lys  Glu Glu Glu 
    3050                 3055                 3060             


Gln Lys  Ile Phe Gly Leu Met  Val Asp Arg Gln Ser  Gln Gly Thr 
    3065                 3070                 3075             


Thr Pro  Asp Thr Thr Pro Ala  Arg Thr Pro Thr Glu  Glu Gly Thr 
    3080                 3085                 3090             


Pro Thr  Ser Glu Gln Asn Pro  Phe Leu Phe Gln Glu  Gly Lys Leu 
    3095                 3100                 3105             


Phe Glu  Met Thr Arg Ser Gly  Ala Ile Asp Met Thr  Lys Arg Ser 
    3110                 3115                 3120             


Tyr Ala  Asp Glu Ser Phe His  Phe Phe Gln Ile Gly  Gln Glu Ser 
    3125                 3130                 3135             


Arg Glu  Glu Thr Leu Ser Glu  Asp Val Lys Glu Gly  Ala Thr Gly 
    3140                 3145                 3150             


Ala Asp  Pro Leu Pro Leu Glu  Thr Ser Ala Glu Ser  Leu Ala Leu 
    3155                 3160                 3165             


Ser Glu  Ser Lys Glu Thr Val  Asp Asp Glu Ala Asp  Leu Leu Pro 
    3170                 3175                 3180             


Asp Asp  Val Ser Glu Glu Val  Glu Glu Ile Pro Ala  Ser Asp Ala 
    3185                 3190                 3195             


Gln Leu  Asn Ser Gln Met Gly  Ile Ser Ala Ser Thr  Glu Thr Pro 
    3200                 3205                 3210             


Thr Lys  Glu Ala Val Ser Val  Gly Thr Lys Asp Leu  Pro Thr Val 
    3215                 3220                 3225             


Gln Thr  Gly Asp Ile Pro Pro  Leu Ser Gly Val Lys  Gln Ile Ser 
    3230                 3235                 3240             


Cys Pro  Asp Ser Ser Glu Pro  Ala Val Gln Val Gln  Leu Asp Phe 
    3245                 3250                 3255             


Ser Thr  Leu Thr Arg Ser Val  Tyr Ser Asp Arg Gly  Asp Asp Ser 
    3260                 3265                 3270             


Pro Asp  Ser Ser Pro Glu Glu  Gln Lys Ser Val Ile  Glu Ile Pro 
    3275                 3280                 3285             


Thr Ala  Pro Met Glu Asn Val  Pro Phe Thr Glu Ser  Lys Ser Lys 
    3290                 3295                 3300             


Ile Pro  Val Arg Thr Met Pro  Thr Ser Thr Pro Ala  Pro Pro Ser 
    3305                 3310                 3315             


Ala Glu  Tyr Glu Ser Ser Val  Ser Glu Asp Phe Leu  Ser Ser Val 
    3320                 3325                 3330             


Asp Glu  Glu Asn Lys Ala Asp  Glu Ala Lys Pro Lys  Ser Lys Leu 
    3335                 3340                 3345             


Pro Val  Lys Val Pro Leu Gln  Arg Val Glu Gln Gln  Leu Ser Asp 
    3350                 3355                 3360             


Leu Asp  Thr Ser Val Gln Lys  Thr Val Ala Pro Gln  Gly Gln Asp 
    3365                 3370                 3375             


Met Ala  Ser Ile Ala Pro Asp  Asn Arg Ser Lys Ser  Glu Ser Asp 
    3380                 3385                 3390             


Ala Ser  Ser Leu Asp Ser Lys  Thr Lys Cys Pro Val  Lys Thr Arg 
    3395                 3400                 3405             


Ser Tyr  Thr Glu Thr Glu Thr  Glu Ser Arg Glu Arg  Ala Glu Glu 
    3410                 3415                 3420             


Leu Glu  Leu Glu Ser Glu Glu  Gly Ala Thr Arg Pro  Lys Ile Leu 
    3425                 3430                 3435             


Thr Ser  Arg Leu Pro Val Lys  Ser Arg Ser Thr Thr  Ser Ser Cys 
    3440                 3445                 3450             


Arg Gly  Gly Thr Ser Pro Thr  Lys Glu Ser Lys Glu  His Phe Phe 
    3455                 3460                 3465             


Asp Leu  Tyr Arg Asn Ser Ile  Glu Phe Phe Glu Glu  Ile Ser Asp 
    3470                 3475                 3480             


Glu Ala  Ser Lys Leu Val Asp  Arg Leu Thr Gln Ser  Glu Arg Glu 
    3485                 3490                 3495             


Gln Glu  Ile Val Ser Asp Asp  Glu Ser Ser Ser Ala  Leu Glu Val 
    3500                 3505                 3510             


Ser Val  Ile Glu Asn Leu Pro  Pro Val Glu Thr Glu  His Ser Val 
    3515                 3520                 3525             


Pro Glu  Asp Ile Phe Asp Thr  Arg Pro Ile Trp Asp  Glu Ser Ile 
    3530                 3535                 3540             


Glu Thr  Leu Ile Glu Arg Ile  Pro Asp Glu Asn Gly  His Asp His 
    3545                 3550                 3555             


Ala Glu  Asp Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    3560                 3565                 3570             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    3575                 3580                 3585             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    3590                 3595                 3600             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    3605                 3610                 3615             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    3620                 3625                 3630             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    3635                 3640                 3645             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    3650                 3655                 3660             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    3665                 3670                 3675             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    3680                 3685                 3690             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    3695                 3700                 3705             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    3710                 3715                 3720             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    3725                 3730                 3735             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    3740                 3745                 3750             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    3755                 3760                 3765             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    3770                 3775                 3780             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    3785                 3790                 3795             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    3800                 3805                 3810             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    3815                 3820                 3825             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    3830                 3835                 3840             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    3845                 3850                 3855             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    3860                 3865                 3870             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    3875                 3880                 3885             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    3890                 3895                 3900             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    3905                 3910                 3915             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    3920                 3925                 3930             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    3935                 3940                 3945             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    3950                 3955         


<210>  25
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Thr Thr Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys Gly Asn Thr Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr Glu Asp Gly Phe Thr 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Thr 
        195                 200                 205             


Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Thr Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu Thr Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly Glu Thr Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Thr Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Thr Thr Asn Gly Tyr Thr Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr Lys Lys Gly Phe Thr 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu 
                565                 570                 575     


Thr Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu 
            580                 585                 590         


Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Thr Ala Lys Asn Gly 
        595                 600                 605             


Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala 
    610                 615                 620                 


Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn Ile Val Thr Lys Gln 
625                 630                 635                 640 


Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu Gly His Thr Asp Met 
                645                 650                 655     


Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Thr Lys 
            660                 665                 670         


Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn 
        675                 680                 685             


Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp Gln Asp Ala His Thr 
    690                 695                 700                 


Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val 
705                 710                 715                 720 


Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys 
                725                 730                 735     


Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly His 
            740                 745                 750         


Thr His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala 
        755                 760                 765             


Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile Ala Lys Arg Leu Gly 
    770                 775                 780                 


Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val Thr Glu Glu Val Thr 
785                 790                 795                 800 


Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys Leu Asn Val Pro Glu 
                805                 810                 815     


Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Thr 
            820                 825                 830         


Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu 
        835                 840                 845             


Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn 
    850                 855                 860                 


Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser 
865                 870                 875                 880 


Phe Ser Ser Asp Arg Ser His Thr Leu Ser His Ala Ser Tyr Leu Arg 
                885                 890                 895     


Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val 
            900                 905                 910         


Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp 
        915                 920                 925             


Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His 
    930                 935                 940                 


Ser Gly Arg Ala Ser Pro Cys Leu Glu Arg Asp Asn Ser Ser Phe Leu 
945                 950                 955                 960 


Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg 
                965                 970                 975     


His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro 
            980                 985                 990         


Thr Arg Val Thr Cys Arg Leu Val  Lys Arg His Arg Leu  Ala Thr Met 
        995                 1000                 1005             


Pro Pro  Met Val Glu Gly Glu  Gly Leu Ala Ser Arg  Leu Ile Glu 
    1010                 1015                 1020             


Val Gly  Pro Ser Gly Ala Gln  Phe Leu Gly Lys Leu  His Leu Pro 
    1025                 1030                 1035             


Thr Ala  Pro Pro Pro Leu Asn  Glu Gly Glu Ser Leu  Val Ser Arg 
    1040                 1045                 1050             


Ile Leu  Gln Leu Gly Pro Pro  Gly Thr Lys Phe Leu  Gly Pro Val 
    1055                 1060                 1065             


Ile Val  Glu Ile Pro His Phe  Ala Ala Leu Arg Gly  Lys Glu Arg 
    1070                 1075                 1080             


Glu Leu  Val Val Leu Arg Ser  Glu Asn Gly Asp Ser  Trp Lys Glu 
    1085                 1090                 1095             


His Phe  Cys Asp Tyr Thr Glu  Asp Glu Leu Asn Glu  Ile Leu Asn 
    1100                 1105                 1110             


Gly Met  Asp Glu Val Leu Asp  Ser Pro Glu Asp Leu  Glu Lys Lys 
    1115                 1120                 1125             


Arg Ile  Cys Arg Ile Ile Thr  Arg Asp Phe Pro Gln  Tyr Phe Ala 
    1130                 1135                 1140             


Val Val  Ser Arg Ile Lys Gln  Asp Ser Asn Leu Ile  Gly Pro Glu 
    1145                 1150                 1155             


Gly Gly  Val Leu Ser Ser Thr  Val Val Pro Gln Val  Gln Ala Val 
    1160                 1165                 1170             


Phe Pro  Glu Gly Ala Leu Thr  Lys Arg Ile Arg Val  Gly Leu Gln 
    1175                 1180                 1185             


Ala Gln  Pro Met His Ser Glu  Leu Val Lys Lys Ile  Leu Gly Asn 
    1190                 1195                 1200             


Lys Ala  Thr Phe Ser Pro Ile  Val Thr Leu Glu Pro  Arg Arg Arg 
    1205                 1210                 1215             


Lys Phe  His Lys Pro Ile Thr  Met Thr Ile Pro Val  Pro Lys Ala 
    1220                 1225                 1230             


Ser Ser  Asp Val Met Leu Asn  Gly Phe Gly Gly Asp  Ala Pro Thr 
    1235                 1240                 1245             


Leu Arg  Leu Leu Cys Ser Ile  Thr Gly Gly Thr Thr  Pro Ala Gln 
    1250                 1255                 1260             


Trp Glu  Asp Ile Thr Gly Thr  Thr Pro Leu Thr Phe  Val Asn Glu 
    1265                 1270                 1275             


Cys Val  Ser Phe Thr Thr Asn  Val Ser Ala Arg Phe  Trp Leu Ile 
    1280                 1285                 1290             


Asp Cys  Arg Gln Ile Gln Glu  Ser Val Thr Phe Ala  Ser Gln Val 
    1295                 1300                 1305             


Tyr Arg  Glu Ile Ile Cys Val  Pro Tyr Met Ala Lys  Phe Val Val 
    1310                 1315                 1320             


Phe Ala  Lys Ser His Asp Pro  Ile Glu Ala Arg Leu  Arg Cys Phe 
    1325                 1330                 1335             


Cys Met  Thr Asp Asp Lys Val  Asp Lys Thr Leu Glu  Gln Gln Glu 
    1340                 1345                 1350             


Asn Phe  Ala Glu Val Ala Arg  Ser Arg Asp Val Glu  Val Leu Glu 
    1355                 1360                 1365             


Gly Lys  Pro Ile Tyr Val Asp  Cys Phe Gly Asn Leu  Val Pro Leu 
    1370                 1375                 1380             


Thr Lys  Ser Gly Gln His His  Ile Phe Ser Phe Phe  Ala Phe Lys 
    1385                 1390                 1395             


Glu Asn  Arg Leu Pro Leu Phe  Val Lys Val Arg Asp  Thr Thr Gln 
    1400                 1405                 1410             


Glu Pro  Cys Gly Arg Leu Ser  Phe Met Lys Glu Pro  Lys Ser Thr 
    1415                 1420                 1425             


Arg Gly  Leu Val His Gln Ala  Ile Cys Asn Leu Asn  Ile Thr Leu 
    1430                 1435                 1440             


Pro Ile  Tyr Thr Lys Glu Ser  Glu Ser Asp Gln Glu  Gln Glu Glu 
    1445                 1450                 1455             


Glu Ile  Asp Met Thr Ser Glu  Lys Asn Pro Gln Asp  Glu Gln Glu 
    1460                 1465                 1470             


Arg Ile  Glu Glu Arg Leu Ala  Tyr Ile Ala Asp His  Leu Gly Phe 
    1475                 1480                 1485             


Ser Trp  Thr Glu Leu Ala Arg  Glu Leu Asp Phe Thr  Glu Glu Gln 
    1490                 1495                 1500             


Ile His  Gln Ile Arg Ile Glu  Asn Pro Asn Ser Leu  Gln Asp Gln 
    1505                 1510                 1515             


Ser His  Ala Leu Leu Lys Tyr  Trp Leu Glu Arg Asp  Gly Lys His 
    1520                 1525                 1530             


Ala Thr  Asp Thr Asn Leu Val  Glu Cys Leu Thr Lys  Ile Asn Arg 
    1535                 1540                 1545             


Met Asp  Ile Val His Leu Met  Glu Thr Asn Thr Glu  Pro Leu Gln 
    1550                 1555                 1560             


Glu Arg  Ile Ser His Ser Tyr  Ala Glu Ile Glu Gln  Thr Ile Thr 
    1565                 1570                 1575             


Leu Asp  His Ser Glu Gly Phe  Ser Val Leu Gln Glu  Glu Leu Cys 
    1580                 1585                 1590             


Thr Ala  Gln His Lys Gln Lys  Glu Glu Gln Ala Val  Ser Lys Glu 
    1595                 1600                 1605             


Ser Glu  Thr Cys Asp His Pro  Pro Ile Val Ser Glu  Glu Asp Ile 
    1610                 1615                 1620             


Ser Val  Gly Tyr Ser Thr Phe  Gln Asp Gly Val Pro  Lys Thr Glu 
    1625                 1630                 1635             


Gly Asp  Ser Ser Ala Thr Ala  Leu Phe Pro Gln Thr  His Lys Glu 
    1640                 1645                 1650             


Gln Val  Gln Gln Asp Phe Ser  Gly Lys Met Gln Asp  Leu Pro Glu 
    1655                 1660                 1665             


Glu Ser  Ser Leu Glu Tyr Gln  Gln Glu Tyr Phe Val  Thr Thr Pro 
    1670                 1675                 1680             


Gly Thr  Glu Thr Ser Glu Thr  Gln Lys Ala Met Ile  Val Pro Ser 
    1685                 1690                 1695             


Ser Pro  Ser Lys Thr Pro Glu  Glu Val Ser Thr Pro  Ala Glu Glu 
    1700                 1705                 1710             


Glu Lys  Leu Tyr Leu Gln Thr  Pro Thr Ser Ser Glu  Arg Gly Gly 
    1715                 1720                 1725             


Ser Pro  Ile Ile Gln Glu Pro  Glu Glu Pro Ser Glu  His Arg Glu 
    1730                 1735                 1740             


Glu Ser  Ser Pro Arg Lys Thr  Ser Leu Val Ile Val  Glu Ser Ala 
    1745                 1750                 1755             


Asp Asn  Gln Pro Glu Thr Cys  Glu Arg Leu Asp Glu  Asp Ala Ala 
    1760                 1765                 1770             


Phe Glu  Lys Gly Asp Asp Met  Pro Glu Ile Pro Pro  Glu Thr Val 
    1775                 1780                 1785             


Thr Glu  Glu Glu Tyr Ile Asp  Glu His Gly His Thr  Val Val Lys 
    1790                 1795                 1800             


Lys Val  Thr Arg Lys Ile Ile  Arg Arg Tyr Val Ser  Ser Glu Gly 
    1805                 1810                 1815             


Thr Glu  Lys Glu Glu Ile Met  Val Gln Gly Met Pro  Gln Glu Pro 
    1820                 1825                 1830             


Val Asn  Ile Glu Glu Gly Asp  Gly Tyr Ser Lys Val  Ile Lys Arg 
    1835                 1840                 1845             


Val Val  Leu Lys Ser Asp Thr  Glu Gln Ser Glu Asp  Asn Asn Glu 
    1850                 1855                 1860             


<210>  26
<211>  3957
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Asp Glu Thr Glu  Ser Thr Glu Thr Ser  Val Leu Lys 
    1475                 1480                 1485             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1490                 1495                 1500             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Thr 
    1505                 1510                 1515             


Ala Ile  Leu Thr Thr Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1520                 1525                 1530             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1535                 1540                 1545             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1550                 1555                 1560             


Glu Ile  Leu Arg Ser Gly Thr  Cys Thr Arg Asp Glu  Ser Ser Val 
    1565                 1570                 1575             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1580                 1585                 1590             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1595                 1600                 1605             


Leu Glu  Ile Thr Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1610                 1615                 1620             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Thr Gly  Leu Val Asn 
    1625                 1630                 1635             


Tyr Leu  Thr Asp Asp Leu Asn  Thr Cys Val Pro Leu  Pro Lys Glu 
    1640                 1645                 1650             


Gln Leu  Gln Thr Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1655                 1660                 1665             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1670                 1675                 1680             


Pro Asp  Glu Thr Gln Ser Thr  Gln Lys Gln His Lys  Pro Ser Leu 
    1685                 1690                 1695             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1700                 1705                 1710             


Gln Lys  Glu Glu Gly Leu Gln  Ala Ser Ala Glu Lys  Ala Glu Leu 
    1715                 1720                 1725             


Lys Lys  Gly Ser Ser Glu Glu  Ser Leu Gly Glu Asp  Pro Gly Leu 
    1730                 1735                 1740             


Ala Pro  Glu Pro Leu Pro Thr  Val Lys Ala Thr Ser  Pro Leu Ile 
    1745                 1750                 1755             


Glu Glu  Thr Pro Ile Gly Ser  Ile Lys Asp Lys Val  Lys Ala Leu 
    1760                 1765                 1770             


Gln Lys  Arg Val Glu Asp Glu  Gln Lys Gly Arg Ser  Lys Leu Pro 
    1775                 1780                 1785             


Ile Arg  Val Lys Gly Lys Glu  Asp Val Pro Lys Lys  Thr Thr His 
    1790                 1795                 1800             


Arg Pro  His Pro Ala Ala Ser  Pro Ser Leu Lys Ser  Glu Arg His 
    1805                 1810                 1815             


Ala Pro  Gly Ser Pro Ser Pro  Lys Thr Glu Arg His  Ser Thr Leu 
    1820                 1825                 1830             


Ser Ser  Ser Ala Lys Thr Glu  Arg His Pro Pro Val  Ser Pro Ser 
    1835                 1840                 1845             


Ser Lys  Thr Glu Lys His Ser  Pro Val Ser Pro Ser  Ala Lys Thr 
    1850                 1855                 1860             


Glu Arg  His Ser Pro Ala Ser  Ser Ser Ser Lys Thr  Glu Lys His 
    1865                 1870                 1875             


Ser Pro  Val Ser Pro Ser Thr  Lys Thr Glu Arg His  Ser Pro Val 
    1880                 1885                 1890             


Ser Ser  Thr Lys Thr Glu Arg  His Pro Pro Val Ser  Pro Ser Gly 
    1895                 1900                 1905             


Lys Thr  Asp Lys Arg Pro Pro  Val Ser Pro Ser Gly  Arg Thr Glu 
    1910                 1915                 1920             


Lys His  Pro Pro Val Ser Pro  Gly Arg Thr Glu Lys  Arg Leu Pro 
    1925                 1930                 1935             


Val Ser  Pro Ser Gly Arg Thr  Asp Lys His Gln Pro  Val Ser Thr 
    1940                 1945                 1950             


Ala Gly  Lys Thr Glu Lys His  Leu Pro Val Ser Pro  Ser Gly Lys 
    1955                 1960                 1965             


Thr Glu  Lys Gln Pro Pro Val  Ser Pro Thr Ser Lys  Thr Glu Arg 
    1970                 1975                 1980             


Ile Glu  Glu Thr Met Ser Val  Arg Glu Leu Met Lys  Ala Phe Gln 
    1985                 1990                 1995             


Ser Gly  Gln Asp Pro Ser Lys  His Lys Thr Gly Leu  Phe Glu His 
    2000                 2005                 2010             


Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Glu Lys Gly  Lys Val Arg 
    2015                 2020                 2025             


Val Glu  Lys Glu Lys Gly Pro  Ile Leu Thr Gln Arg  Glu Ala Gln 
    2030                 2035                 2040             


Lys Thr  Glu Asn Gln Thr Ile  Lys Arg Gly Gln Arg  Leu Pro Val 
    2045                 2050                 2055             


Thr Gly  Thr Ala Glu Ser Lys  Arg Gly Val Arg Val  Ser Ser Ile 
    2060                 2065                 2070             


Gly Val  Lys Lys Glu Asp Ala  Ala Gly Gly Lys Glu  Lys Val Leu 
    2075                 2080                 2085             


Ser His  Lys Ile Pro Glu Pro  Val Gln Ser Val Pro  Glu Glu Glu 
    2090                 2095                 2100             


Ser His  Arg Glu Ser Glu Val  Pro Lys Glu Lys Met  Ala Asp Glu 
    2105                 2110                 2115             


Gln Gly  Asp Met Asp Leu Gln  Ile Ser Pro Asp Arg  Lys Thr Ser 
    2120                 2125                 2130             


Thr Asp  Phe Ser Glu Val Ile  Lys Gln Glu Leu Glu  Asp Asn Asp 
    2135                 2140                 2145             


Lys Tyr  Gln Gln Phe Arg Leu  Ser Glu Glu Thr Glu  Lys Ala Gln 
    2150                 2155                 2160             


Leu His  Leu Asp Gln Val Leu  Thr Ser Pro Phe Asn  Thr Thr Phe 
    2165                 2170                 2175             


Pro Leu  Asp Tyr Met Lys Asp  Glu Phe Leu Pro Ala  Leu Ser Leu 
    2180                 2185                 2190             


Gln Ser  Gly Ala Leu Asp Gly  Ser Ser Glu Ser Leu  Lys Asn Glu 
    2195                 2200                 2205             


Gly Val  Ala Gly Ser Pro Cys  Gly Ser Leu Met Glu  Gly Thr Pro 
    2210                 2215                 2220             


Gln Ile  Ser Ser Glu Glu Ser  Tyr Lys His Glu Gly  Leu Ala Glu 
    2225                 2230                 2235             


Thr Pro  Glu Thr Ser Pro Glu  Ser Leu Ser Phe Ser  Pro Lys Lys 
    2240                 2245                 2250             


Ser Glu  Glu Gln Thr Gly Glu  Thr Lys Glu Ser Thr  Lys Thr Glu 
    2255                 2260                 2265             


Thr Thr  Thr Glu Ile Arg Ser  Glu Lys Glu His Pro  Thr Thr Lys 
    2270                 2275                 2280             


Asp Ile  Thr Gly Gly Ser Glu  Glu Arg Gly Ala Thr  Val Thr Glu 
    2285                 2290                 2295             


Asp Ser  Glu Thr Ser Thr Glu  Ser Phe Gln Lys Glu  Ala Thr Leu 
    2300                 2305                 2310             


Gly Ser  Pro Lys Asp Thr Ser  Pro Lys Arg Gln Asp  Asp Cys Thr 
    2315                 2320                 2325             


Gly Ser  Cys Ser Val Ala Leu  Ala Lys Glu Thr Pro  Thr Gly Leu 
    2330                 2335                 2340             


Thr Glu  Glu Ala Ala Cys Asp  Glu Gly Gln Arg Thr  Phe Gly Ser 
    2345                 2350                 2355             


Ser Ala  His Lys Thr Gln Thr  Asp Ser Glu Val Gln  Glu Ser Thr 
    2360                 2365                 2370             


Ala Thr  Ser Asp Glu Thr Lys  Ala Leu Pro Leu Pro  Glu Ala Ser 
    2375                 2380                 2385             


Val Lys  Thr Asp Thr Gly Thr  Glu Ser Lys Pro Gln  Gly Val Ile 
    2390                 2395                 2400             


Arg Ser  Pro Gln Gly Leu Glu  Leu Ala Leu Pro Ser  Arg Asp Ser 
    2405                 2410                 2415             


Glu Val  Leu Ser Ala Val Ala  Asp Asp Ser Leu Ala  Val Ser His 
    2420                 2425                 2430             


Lys Asp  Ser Leu Glu Ala Ser  Pro Val Leu Glu Asp  Asn Ser Ser 
    2435                 2440                 2445             


His Lys  Thr Pro Asp Ser Leu  Glu Pro Ser Pro Leu  Lys Glu Ser 
    2450                 2455                 2460             


Pro Cys  Arg Asp Ser Leu Glu  Ser Ser Pro Val Glu  Pro Lys Met 
    2465                 2470                 2475             


Lys Ala  Gly Ile Phe Pro Ser  His Phe Pro Leu Pro  Ala Ala Val 
    2480                 2485                 2490             


Ala Lys  Thr Glu Leu Leu Thr  Glu Val Ala Ser Val  Arg Ser Arg 
    2495                 2500                 2505             


Leu Leu  Arg Asp Pro Asp Gly  Ser Ala Glu Asp Asp  Ser Leu Glu 
    2510                 2515                 2520             


Gln Thr  Ser Leu Met Glu Ser  Ser Gly Lys Ser Pro  Leu Ser Pro 
    2525                 2530                 2535             


Asp Thr  Pro Ser Ser Glu Glu  Val Ser Tyr Glu Val  Thr Pro Lys 
    2540                 2545                 2550             


Thr Thr  Asp Val Ser Thr Pro  Lys Pro Ala Val Ile  His Glu Cys 
    2555                 2560                 2565             


Ala Glu  Glu Asp Asp Ser Glu  Asn Gly Glu Lys Lys  Arg Phe Thr 
    2570                 2575                 2580             


Pro Glu  Glu Glu Met Phe Lys  Met Val Thr Lys Ile  Lys Met Phe 
    2585                 2590                 2595             


Asp Glu  Leu Glu Gln Glu Ala  Lys Gln Lys Arg Asp  Tyr Lys Lys 
    2600                 2605                 2610             


Glu Pro  Lys Gln Glu Glu Ser  Ser Ser Ser Ser Asp  Pro Asp Ala 
    2615                 2620                 2625             


Asp Cys  Ser Val Asp Val Asp  Glu Pro Lys His Thr  Gly Ser Gly 
    2630                 2635                 2640             


Glu Asp  Glu Ser Gly Val Pro  Val Leu Val Thr Ser  Glu Ser Arg 
    2645                 2650                 2655             


Lys Val  Ser Ser Ser Ser Glu  Ser Glu Pro Glu Leu  Ala Gln Leu 
    2660                 2665                 2670             


Lys Lys  Gly Ala Asp Ser Gly  Leu Leu Pro Glu Pro  Val Ile Arg 
    2675                 2680                 2685             


Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser Met Asp  Ser Asn Ser 
    2690                 2695                 2700             


Ser Pro  Glu Glu Val Gln Phe  Gln Pro Val Val Ser  Lys Gln Tyr 
    2705                 2710                 2715             


Thr Phe  Lys Met Asn Glu Asp  Thr Gln Glu Glu Pro  Gly Lys Ser 
    2720                 2725                 2730             


Glu Glu  Glu Lys Asp Ser Glu  Ser His Leu Ala Glu  Asp Arg His 
    2735                 2740                 2745             


Ala Val  Ser Thr Glu Ala Glu  Asp Arg Ser Tyr Asp  Lys Leu Asn 
    2750                 2755                 2760             


Arg Asp  Thr Asp Gln Pro Lys  Ile Cys Asp Gly His  Gly Cys Glu 
    2765                 2770                 2775             


Ala Met  Ser Pro Ser Ser Ser  Ala Ala Pro Val Ser  Ser Gly Leu 
    2780                 2785                 2790             


Gln Ser  Pro Thr Gly Asp Asp  Val Asp Glu Gln Pro  Val Ile Tyr 
    2795                 2800                 2805             


Lys Glu  Ser Leu Ala Leu Gln  Gly Thr His Glu Lys  Asp Thr Glu 
    2810                 2815                 2820             


Gly Glu  Glu Leu Asp Val Ser  Arg Ala Glu Ser Pro  Gln Ala Asp 
    2825                 2830                 2835             


Cys Pro  Ser Glu Ser Phe Ser  Ser Ser Ser Ser Leu  Pro His Cys 
    2840                 2845                 2850             


Leu Val  Ser Glu Gly Lys Glu  Leu Asp Glu Asp Ile  Ser Ala Thr 
    2855                 2860                 2865             


Ser Ser  Ile Gln Lys Thr Glu  Val Thr Lys Thr Asp  Glu Thr Phe 
    2870                 2875                 2880             


Glu Asn  Leu Pro Lys Asp Cys  Pro Ser Gln Asp Ser  Ser Ile Thr 
    2885                 2890                 2895             


Thr Gln  Thr Asp Arg Phe Ser  Met Asp Val Pro Val  Ser Asp Leu 
    2900                 2905                 2910             


Ala Glu  Asn Asp Glu Ile Tyr  Asp Pro Gln Ile Thr  Ser Pro Tyr 
    2915                 2920                 2925             


Glu Asn  Val Pro Ser Gln Ser  Phe Phe Ser Ser Glu  Glu Ser Lys 
    2930                 2935                 2940             


Thr Gln  Thr Asp Ala Asn His  Thr Thr Ser Phe His  Ser Ser Glu 
    2945                 2950                 2955             


Val Tyr  Ser Val Thr Ile Thr  Ser Pro Val Glu Asp  Val Val Val 
    2960                 2965                 2970             


Ala Ser  Ser Ser Ser Gly Thr  Val Leu Ser Lys Glu  Ser Asn Phe 
    2975                 2980                 2985             


Glu Gly  Gln Asp Ile Lys Met  Glu Ser Gln Gln Glu  Ser Thr Leu 
    2990                 2995                 3000             


Trp Glu  Met Gln Ser Asp Ser  Val Ser Ser Ser Phe  Glu Pro Thr 
    3005                 3010                 3015             


Met Ser  Ala Thr Thr Thr Val  Val Gly Glu Gln Ile  Ser Lys Val 
    3020                 3025                 3030             


Ile Ile  Thr Lys Thr Asp Val  Asp Ser Asp Ser Trp  Ser Glu Ile 
    3035                 3040                 3045             


Arg Glu  Asp Asp Glu Ala Phe  Glu Ala Arg Val Lys  Glu Glu Glu 
    3050                 3055                 3060             


Gln Lys  Ile Phe Gly Leu Met  Val Asp Arg Gln Ser  Gln Gly Thr 
    3065                 3070                 3075             


Thr Pro  Asp Thr Thr Pro Ala  Arg Thr Pro Thr Glu  Glu Gly Thr 
    3080                 3085                 3090             


Pro Thr  Ser Glu Gln Asn Pro  Phe Leu Phe Gln Glu  Gly Lys Leu 
    3095                 3100                 3105             


Phe Glu  Met Thr Arg Ser Gly  Ala Ile Asp Met Thr  Lys Arg Ser 
    3110                 3115                 3120             


Tyr Ala  Asp Glu Ser Phe His  Phe Phe Gln Ile Gly  Gln Glu Ser 
    3125                 3130                 3135             


Arg Glu  Glu Thr Leu Ser Glu  Asp Val Lys Glu Gly  Ala Thr Gly 
    3140                 3145                 3150             


Ala Asp  Pro Leu Pro Leu Glu  Thr Ser Ala Glu Ser  Leu Ala Leu 
    3155                 3160                 3165             


Ser Glu  Ser Lys Glu Thr Val  Asp Asp Glu Ala Asp  Leu Leu Pro 
    3170                 3175                 3180             


Asp Asp  Val Ser Glu Glu Val  Glu Glu Ile Pro Ala  Ser Asp Ala 
    3185                 3190                 3195             


Gln Leu  Asn Ser Gln Met Gly  Ile Ser Ala Ser Thr  Glu Thr Pro 
    3200                 3205                 3210             


Thr Lys  Glu Ala Val Ser Val  Gly Thr Lys Asp Leu  Pro Thr Val 
    3215                 3220                 3225             


Gln Thr  Gly Asp Ile Pro Pro  Leu Ser Gly Val Lys  Gln Ile Ser 
    3230                 3235                 3240             


Cys Pro  Asp Ser Ser Glu Pro  Ala Val Gln Val Gln  Leu Asp Phe 
    3245                 3250                 3255             


Ser Thr  Leu Thr Arg Ser Val  Tyr Ser Asp Arg Gly  Asp Asp Ser 
    3260                 3265                 3270             


Pro Asp  Ser Ser Pro Glu Glu  Gln Lys Ser Val Ile  Glu Ile Pro 
    3275                 3280                 3285             


Thr Ala  Pro Met Glu Asn Val  Pro Phe Thr Glu Ser  Lys Ser Lys 
    3290                 3295                 3300             


Ile Pro  Val Arg Thr Met Pro  Thr Ser Thr Pro Ala  Pro Pro Ser 
    3305                 3310                 3315             


Ala Glu  Tyr Glu Ser Ser Val  Ser Glu Asp Phe Leu  Ser Ser Val 
    3320                 3325                 3330             


Asp Glu  Glu Asn Lys Ala Asp  Glu Ala Lys Pro Lys  Ser Lys Leu 
    3335                 3340                 3345             


Pro Val  Lys Val Pro Leu Gln  Arg Val Glu Gln Gln  Leu Ser Asp 
    3350                 3355                 3360             


Leu Asp  Thr Ser Val Gln Lys  Thr Val Ala Pro Gln  Gly Gln Asp 
    3365                 3370                 3375             


Met Ala  Ser Ile Ala Pro Asp  Asn Arg Ser Lys Ser  Glu Ser Asp 
    3380                 3385                 3390             


Ala Ser  Ser Leu Asp Ser Lys  Thr Lys Cys Pro Val  Lys Thr Arg 
    3395                 3400                 3405             


Ser Tyr  Thr Glu Thr Glu Thr  Glu Ser Arg Glu Arg  Ala Glu Glu 
    3410                 3415                 3420             


Leu Glu  Leu Glu Ser Glu Glu  Gly Ala Thr Arg Pro  Lys Ile Leu 
    3425                 3430                 3435             


Thr Ser  Arg Leu Pro Val Lys  Ser Arg Ser Thr Thr  Ser Ser Cys 
    3440                 3445                 3450             


Arg Gly  Gly Thr Ser Pro Thr  Lys Glu Ser Lys Glu  His Phe Phe 
    3455                 3460                 3465             


Asp Leu  Tyr Arg Asn Ser Ile  Glu Phe Phe Glu Glu  Ile Ser Asp 
    3470                 3475                 3480             


Glu Ala  Ser Lys Leu Val Asp  Arg Leu Thr Gln Ser  Glu Arg Glu 
    3485                 3490                 3495             


Gln Glu  Ile Val Ser Asp Asp  Glu Ser Ser Ser Ala  Leu Glu Val 
    3500                 3505                 3510             


Ser Val  Ile Glu Asn Leu Pro  Pro Val Glu Thr Glu  His Ser Val 
    3515                 3520                 3525             


Pro Glu  Asp Ile Phe Asp Thr  Arg Pro Ile Trp Asp  Glu Ser Ile 
    3530                 3535                 3540             


Glu Thr  Leu Ile Glu Arg Ile  Pro Asp Glu Asn Gly  His Asp His 
    3545                 3550                 3555             


Ala Glu  Asp Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    3560                 3565                 3570             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    3575                 3580                 3585             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    3590                 3595                 3600             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    3605                 3610                 3615             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    3620                 3625                 3630             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    3635                 3640                 3645             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    3650                 3655                 3660             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    3665                 3670                 3675             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    3680                 3685                 3690             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    3695                 3700                 3705             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    3710                 3715                 3720             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    3725                 3730                 3735             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    3740                 3745                 3750             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    3755                 3760                 3765             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    3770                 3775                 3780             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    3785                 3790                 3795             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    3800                 3805                 3810             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    3815                 3820                 3825             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    3830                 3835                 3840             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    3845                 3850                 3855             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    3860                 3865                 3870             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    3875                 3880                 3885             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    3890                 3895                 3900             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    3905                 3910                 3915             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    3920                 3925                 3930             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    3935                 3940                 3945             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    3950                 3955         


<210>  27
<211>  1872
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    1475                 1480                 1485             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    1490                 1495                 1500             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    1505                 1510                 1515             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    1520                 1525                 1530             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    1535                 1540                 1545             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    1550                 1555                 1560             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    1565                 1570                 1575             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    1580                 1585                 1590             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    1595                 1600                 1605             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    1610                 1615                 1620             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    1625                 1630                 1635             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    1640                 1645                 1650             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    1655                 1660                 1665             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    1670                 1675                 1680             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    1685                 1690                 1695             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    1700                 1705                 1710             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    1715                 1720                 1725             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    1730                 1735                 1740             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    1745                 1750                 1755             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    1760                 1765                 1770             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    1775                 1780                 1785             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    1790                 1795                 1800             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    1805                 1810                 1815             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    1820                 1825                 1830             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    1835                 1840                 1845             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    1850                 1855                 1860             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    1865                 1870         


<210>  28
<211>  3898
<212>  PRT
<213>  Mus musculus

<400>  28

Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Lys Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln Tyr Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Thr Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Arg Asp Ala Tyr Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Val Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Met Ile Asp Asp Thr Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Ala Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Pro Val Ile  Val Glu Ile Pro His  Phe Ala Ala 
    1040                 1045                 1050             


Leu Arg  Gly Lys Glu Arg Glu  Leu Val Val Leu Arg  Ser Glu Asn 
    1055                 1060                 1065             


Gly Asp  Ser Trp Lys Glu His  Phe Cys Asp Tyr Thr  Glu Asp Glu 
    1070                 1075                 1080             


Leu Asn  Glu Ile Leu Asn Gly  Met Asp Glu Val Leu  Asp Ser Pro 
    1085                 1090                 1095             


Glu Asp  Leu Glu Lys Lys Arg  Ile Cys Arg Ile Ile  Thr Arg Asp 
    1100                 1105                 1110             


Phe Pro  Gln Tyr Phe Ala Val  Val Ser Arg Ile Lys  Gln Asp Ser 
    1115                 1120                 1125             


Asn Leu  Ile Gly Pro Glu Gly  Gly Val Leu Ser Ser  Thr Val Val 
    1130                 1135                 1140             


Ser Gln  Val Gln Ala Val Phe  Pro Glu Gly Ala Leu  Thr Lys Arg 
    1145                 1150                 1155             


Ile Arg  Val Gly Leu Gln Ala  Gln Pro Met His Ser  Glu Leu Val 
    1160                 1165                 1170             


Lys Lys  Ile Leu Gly Asn Lys  Ala Thr Phe Ser Pro  Ile Val Thr 
    1175                 1180                 1185             


Leu Glu  Pro Arg Arg Arg Lys  Phe His Lys Pro Ile  Thr Met Thr 
    1190                 1195                 1200             


Ile Pro  Val Pro Lys Ala Ser  Ser Asp Val Met Leu  Asn Gly Phe 
    1205                 1210                 1215             


Gly Gly  Asp Ala Pro Thr Leu  Arg Leu Leu Cys Ser  Ile Thr Gly 
    1220                 1225                 1230             


Gly Thr  Thr Pro Ala Gln Trp  Glu Asp Ile Thr Gly  Thr Thr Pro 
    1235                 1240                 1245             


Leu Thr  Phe Val Asn Glu Cys  Val Ser Phe Thr Thr  Asn Val Ser 
    1250                 1255                 1260             


Ala Arg  Phe Trp Leu Ile Asp  Cys Arg Gln Ile Gln  Glu Ser Val 
    1265                 1270                 1275             


Ala Phe  Ala Ser Gln Val Tyr  Arg Glu Ile Ile Cys  Val Pro Tyr 
    1280                 1285                 1290             


Met Ala  Lys Phe Val Val Phe  Ala Lys Ser His Asp  Pro Ile Glu 
    1295                 1300                 1305             


Ala Arg  Leu Arg Cys Phe Cys  Met Thr Asp Asp Lys  Val Asp Lys 
    1310                 1315                 1320             


Thr Leu  Glu Gln Gln Glu Asn  Phe Ser Glu Val Ala  Arg Ser Arg 
    1325                 1330                 1335             


Asp Val  Glu Val Leu Glu Gly  Lys Pro Ile Tyr Val  Asp Cys Phe 
    1340                 1345                 1350             


Gly Asn  Leu Val Pro Leu Thr  Lys Ser Gly Gln His  His Ile Phe 
    1355                 1360                 1365             


Ser Phe  Phe Ala Phe Lys Glu  Asn Arg Leu Pro Leu  Phe Val Lys 
    1370                 1375                 1380             


Val Arg  Asp Thr Thr Gln Glu  Pro Cys Gly Arg Leu  Ser Phe Met 
    1385                 1390                 1395             


Lys Glu  Pro Lys Ser Thr Arg  Gly Leu Val His Gln  Ala Ile Cys 
    1400                 1405                 1410             


Asn Leu  Asn Ile Thr Leu Pro  Ile Tyr Ala Lys Glu  Ser Glu Ser 
    1415                 1420                 1425             


Asp Gln  Glu Pro Glu Glu Glu  Ile Gly Met Thr Ser  Glu Lys Asn 
    1430                 1435                 1440             


Asp Glu  Thr Glu Ser Thr Glu  Thr Ser Val Leu Lys  Ser His Leu 
    1445                 1450                 1455             


Val Asn  Glu Val Pro Val Leu  Ala Ser Pro Asp Leu  Leu Ser Glu 
    1460                 1465                 1470             


Val Ser  Glu Met Lys Gln Asp  Leu Ile Lys Met Thr  Ala Ile Leu 
    1475                 1480                 1485             


Thr Thr  Asp Val Ser Asp Lys  Ala Gly Ser Leu Lys  Val Lys Glu 
    1490                 1495                 1500             


Leu Ala  Lys Ala Gly Glu Glu  Glu Pro Gly Glu Pro  Phe Glu Ile 
    1505                 1510                 1515             


Val Glu  Arg Val Lys Glu Asp  Leu Glu Lys Val Asn  Ala Ile Leu 
    1520                 1525                 1530             


Arg Ser  Gly Thr Cys Met Arg  Asp Glu Gly Arg Ala  Arg Ser Ser 
    1535                 1540                 1545             


Gln Ser  Glu Arg Glu Leu Glu  Glu Glu Trp Val Ile  Val Ser Asp 
    1550                 1555                 1560             


Glu Glu  Ile Gln Glu Ala Lys  Gln His Ala Pro Val  Glu Ile Asp 
    1565                 1570                 1575             


Glu His  Pro Cys Ile Glu Val  Arg Val Asp Arg Glu  Thr Lys Ala 
    1580                 1585                 1590             


Lys Val  Glu Lys Asp Ser Thr  Gly Leu Val Asn Tyr  Leu Thr Asp 
    1595                 1600                 1605             


Asp Leu  Asn Ser Tyr Thr Ser  Pro His Glu Lys Lys  Pro His Thr 
    1610                 1615                 1620             


Ala Pro  Glu Lys Ser Gly Glu  Thr Ser Gln Ala Ser  Ala Val Gly 
    1625                 1630                 1635             


Lys Ser  Ser Glu Ser Asn Lys  Gly Lys Ala Thr Ser  Ala Glu Glu 
    1640                 1645                 1650             


Lys Gln  Ser Ala Gln Lys Gln  Leu Lys Pro Gly Leu  Ala Ile Lys 
    1655                 1660                 1665             


Lys Pro  Val Arg Arg Lys Leu  Lys Glu Lys Gln Lys  Gln Lys Glu 
    1670                 1675                 1680             


Glu Ser  Ser Gln Ser Ser Glu  Glu Lys Thr Glu Leu  Lys Lys Gly 
    1685                 1690                 1695             


Ser Ser  Glu Glu Ser Val Asp  Glu Asp Arg Gly Leu  Val Pro Glu 
    1700                 1705                 1710             


Pro Leu  Pro Thr Ala Lys Ala  Thr Ser Pro Leu Ile  Glu Glu Thr 
    1715                 1720                 1725             


Pro Ile  Gly Ser Ile Lys Asp  Lys Val Lys Ala Leu  Gln Lys Arg 
    1730                 1735                 1740             


Val Glu  Asp Glu Gln Lys Gly  Arg Ser Lys Leu Pro  Val Arg Val 
    1745                 1750                 1755             


Lys Gly  Lys Glu Asp Val Pro  Lys Arg Thr Thr Pro  Arg Thr His 
    1760                 1765                 1770             


Pro Ala  Val Ser Pro Ser Ser  Lys Ser Ser Thr Ser  Ser Lys Ala 
    1775                 1780                 1785             


Glu Arg  His Ser Ser Leu Ser  Ser Ser Ala Lys Pro  Glu Arg His 
    1790                 1795                 1800             


Thr Pro  Val Ser Pro Ser Ser  Lys Asn Glu Lys Leu  Ser Pro Val 
    1805                 1810                 1815             


Ser Pro  Ser Ala Lys Thr Glu  Arg His Ser Pro Val  Phe Ser Gly 
    1820                 1825                 1830             


Lys Pro  Glu Lys His Ser Pro  Gly Ser Pro Ser Thr  Lys Asn Glu 
    1835                 1840                 1845             


Arg His  Ser Pro Val Ser Ser  Leu Lys Thr Glu Arg  His Thr Pro 
    1850                 1855                 1860             


Gly Ser  Pro Ser Gly Lys Thr  Asp Lys Arg Pro Pro  Val Pro Ser 
    1865                 1870                 1875             


Ser Gly  Arg Thr Glu Lys His  Pro Pro Val Ser Pro  Gly Lys Thr 
    1880                 1885                 1890             


Glu Lys  His Leu Pro Gly Ser  Pro Ser Ile Arg Thr  Pro Glu Lys 
    1895                 1900                 1905             


Pro Ala  Pro Gly Ser Ala Thr  Gly Lys His Glu Lys  His Leu Pro 
    1910                 1915                 1920             


Val Ser  Pro Gly Lys Thr Glu  Lys Gln Pro Pro Ile  Ser Pro Thr 
    1925                 1930                 1935             


Ser Lys  Thr Glu Arg Ile Glu  Glu Thr Met Ser Val  Arg Glu Leu 
    1940                 1945                 1950             


Met Lys  Ala Phe Gln Ser Gly  Gln Asp Pro Ser Lys  His Lys Thr 
    1955                 1960                 1965             


Gly Leu  Phe Glu His Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Asp 
    1970                 1975                 1980             


Lys Ser  Lys Ser Arg Val Glu  Lys Glu Lys Gly His  Thr Val Thr 
    1985                 1990                 1995             


Gln Arg  Glu Val Thr Gln Arg  Glu Thr Gln Arg Ile  Glu Ser Gln 
    2000                 2005                 2010             


Thr Ala  Lys Arg Gly Gln Arg  Phe Gln Val Ser Ala  Ala Thr Glu 
    2015                 2020                 2025             


Ser Arg  Arg Phe Arg Ser Thr  Thr Ile Thr Val Gly  Leu Arg Met 
    2030                 2035                 2040             


Glu Asp  Pro Val Arg Glu Arg  Phe Glu Arg Thr Pro  Ile Ile Lys 
    2045                 2050                 2055             


Thr Pro  Glu Val Val Pro Ser  Val Ala Ala Glu Glu  Ser His Arg 
    2060                 2065                 2070             


Gly Ser  Glu Lys Ile Val Asp  Glu Gln Gly Asp Met  Asp Phe Gln 
    2075                 2080                 2085             


Ile Ser  Pro Asp Arg Lys Thr  Ser Thr Asp Phe Ser  Glu Val Ile 
    2090                 2095                 2100             


Lys Gln  Glu Leu Glu Asp Asn  Asp Lys Tyr Gln Gln  Phe Arg Leu 
    2105                 2110                 2115             


Thr Glu  Asp Thr Glu Lys Ala  Gln Val His Leu Asp  Gln Val Ile 
    2120                 2125                 2130             


Thr Ser  Pro Phe Asn Thr Ala  Phe Pro Leu Asp Tyr  Met Lys Asp 
    2135                 2140                 2145             


Glu Phe  Leu Pro Ala Leu Ser  Leu Gln Ser Gly Ala  Leu Gly Gly 
    2150                 2155                 2160             


Ser Ser  Glu Ser Leu Lys Gln  Glu Val Ile Ala Gly  Ser Pro Cys 
    2165                 2170                 2175             


Ser Ser  Leu Met Glu Gly Thr  Pro Gln Ile Ser Ser  Glu Glu Ser 
    2180                 2185                 2190             


Tyr Lys  His Glu Gly Leu Ala  Glu Thr Pro Glu Thr  Ser Pro Glu 
    2195                 2200                 2205             


Ser Leu  Ser Phe Ser Pro Lys  Lys Ser Glu Glu Gln  Ile Gly Glu 
    2210                 2215                 2220             


Ala Lys  Glu Thr Thr Lys Val  Gly Thr Pro Thr Asp  Ile His Ser 
    2225                 2230                 2235             


Glu Lys  Glu Leu Pro Ile Thr  Asn Asp Ile Thr Asp  Ser Ser Gln 
    2240                 2245                 2250             


Lys Gln  Gly Ala Gly Val Thr  Arg Gly Ser Glu Pro  Ser Thr Glu 
    2255                 2260                 2265             


His Ser  Gln Lys Glu Val Thr  Gln Asp Pro His Lys  Asp Val Cys 
    2270                 2275                 2280             


Ser Lys  Gln Asp Gly Cys Pro  Glu Ser Gln Ser Val  Ser Leu Ala 
    2285                 2290                 2295             


Ser Glu  Val Phe Thr Glu Lys  Gly Ser Cys Gly Glu  Ser Gln Leu 
    2300                 2305                 2310             


Pro Leu  Val Ser Ser Ala Phe  Lys Thr Gln Ser Glu  Ser Glu Thr 
    2315                 2320                 2325             


Gln Glu  Ser Leu Thr Pro Ser  Glu Val Thr Lys Pro  Phe Pro Pro 
    2330                 2335                 2340             


Ser Asp  Ala Ser Val Lys Thr  Ala Glu Gly Thr Glu  Pro Lys Pro 
    2345                 2350                 2355             


Gln Gly  Ala Ile Arg Ser Pro  Gln Gly Leu Glu Leu  Pro Leu Pro 
    2360                 2365                 2370             


Asn Arg  Asp Ser Glu Val Leu  Ser Pro Met Ala Asp  Glu Ser Leu 
    2375                 2380                 2385             


Ala Val  Ser His Lys Asp Ser  Leu Glu Ala Ser Pro  Val Leu Glu 
    2390                 2395                 2400             


Asp Asn  Ser Ser His Lys Thr  Pro Asp Ser Leu Glu  Pro Ser Pro 
    2405                 2410                 2415             


Leu Lys  Glu Ser Pro Cys Arg  Asp Ser Leu Glu Ser  Ser Pro Val 
    2420                 2425                 2430             


Glu Pro  Lys Met Lys Ala Gly  Ile Leu Pro Ser His  Phe Pro Leu 
    2435                 2440                 2445             


Pro Ala  Ala Ile Ala Lys Thr  Asp Leu Val Ala Glu  Val Ala Ser 
    2450                 2455                 2460             


Met Arg  Ser Arg Leu Leu Arg  Asp Pro Asp Gly Ser  Ala Glu Asp 
    2465                 2470                 2475             


Asp Ser  Leu Glu Gln Thr Ser  Leu Met Glu Ser Ser  Gly Lys Ser 
    2480                 2485                 2490             


Pro Leu  Ser Pro Asp Thr Pro  Ser Ser Glu Glu Val  Ser Tyr Glu 
    2495                 2500                 2505             


Val Thr  Pro Lys Pro Ser Asp  Ser Ser Thr Pro Lys  Pro Ala Val 
    2510                 2515                 2520             


Ile His  Glu Cys Ala Glu Glu  Asp Asp Ser Glu Asn  Gly Glu Lys 
    2525                 2530                 2535             


Lys Arg  Phe Thr Pro Glu Glu  Glu Met Phe Lys Met  Val Thr Lys 
    2540                 2545                 2550             


Ile Lys  Thr Phe Asp Glu Leu  Glu Gln Glu Ala Lys  Gln Lys Arg 
    2555                 2560                 2565             


Asp Tyr  Lys Lys Glu Pro Arg  Gln Asp Gly Ser Ser  Ser Ala Ser 
    2570                 2575                 2580             


Asp Pro  Asp Ala Asp Tyr Ser  Ala Glu Val Asn Asp  Glu Lys Gln 
    2585                 2590                 2595             


Met Ala  Gly Thr Glu Gly Glu  Gly Glu Val Pro Val  Leu Val Thr 
    2600                 2605                 2610             


Ser Glu  Asn Arg Lys Val Ser  Ser Ser Ser Ser Glu  Ser Glu Pro 
    2615                 2620                 2625             


Glu Leu  Thr Gln Leu Ser Lys  Gly Ala Asp Ser Gly  Leu Leu Thr 
    2630                 2635                 2640             


Glu Pro  Val Ile Arg Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser 
    2645                 2650                 2655             


Ile Asp  Ser Asn Ser Ser Pro  Glu Glu Ala Thr Gln  Phe Gln Pro 
    2660                 2665                 2670             


Ile Val  Pro Lys Gln Tyr Thr  Phe Lys Met Asn Glu  Glu Ile Gln 
    2675                 2680                 2685             


Glu Glu  Pro Ala Thr Ser Glu  Asp Lys Asp Cys Lys  Ser His Leu 
    2690                 2695                 2700             


Ala Glu  Asp Ser Gln Thr His  Ser Ala Asp Ala Ala  Asp Gly Ser 
    2705                 2710                 2715             


Asp Gly  Asp Leu Asn Arg Glu  Thr Thr Gln Pro Glu  Thr Cys Asp 
    2720                 2725                 2730             


Gly His  Gly Cys Glu Thr Val  Ser Pro Ser Asn Ser  Ala Thr Pro 
    2735                 2740                 2745             


Val Ser  Leu Gly Val Gln Ser  Pro Glu His Lys Asp  Val Asp Lys 
    2750                 2755                 2760             


Pro Leu  Ala Ile Asp Lys Asp  Ser Leu Ala His Gln  Asp Thr Cys 
    2765                 2770                 2775             


Glu Asn  Asp Arg Glu Glu Arg  Glu Phe Asp Pro Ser  Gly Val Glu 
    2780                 2785                 2790             


Ser Thr  Gln Ala Asp Leu Pro  Asn Glu Ser Ser Ser  Leu Ser Ser 
    2795                 2800                 2805             


Arg Cys  Ala Ile Pro Glu Gly  Asn Glu Ser Ala Lys  Glu Ile Ala 
    2810                 2815                 2820             


Ser Pro  Ser Ser Pro Val Lys  Val Glu Val Thr Ile  Thr Asp Gln 
    2825                 2830                 2835             


Ala Leu  Glu Ser Met Pro Glu  Asp Cys Pro Ile Gln  Asp Ser Ser 
    2840                 2845                 2850             


Thr Thr  Met Gln Thr Glu Arg  Phe Ala Met Asp Val  Pro Val Ser 
    2855                 2860                 2865             


Glu Leu  Ala Glu Thr Asp Glu  Asn Ser Asp Pro Gln  Ile Ile Ser 
    2870                 2875                 2880             


Pro Tyr  Glu Asn Val Pro Ser  Ser Ser Phe Phe Ser  Ala Glu Pro 
    2885                 2890                 2895             


Ser Lys  Ile Gln Thr Asp Thr  Cys His Ser Thr Val  Val His Ser 
    2900                 2905                 2910             


Pro Glu  Val Tyr Ser Val Ile  Ile Arg Ser Ser Pro  Glu Asp Val 
    2915                 2920                 2925             


Val Val  Thr Asn Ser Ser Asn  Arg Thr Val Ser Gly  Glu Glu Ser 
    2930                 2935                 2940             


His Cys  Glu Ser His Asp Leu  Glu Thr Glu Ser Glu  Gln Lys Ser 
    2945                 2950                 2955             


Ala Leu  Trp Ala Ala Gln Ser  Asp Ala Pro Pro Leu  Ala Val Ala 
    2960                 2965                 2970             


Pro Thr  Ala Ser Asp Ala Ala  Ser Val Thr Gly Glu  Gln Ala Ser 
    2975                 2980                 2985             


Lys Val  Ile Ile Thr Lys Thr  Asp Ala Asp Ala Asp  Ser Trp Ser 
    2990                 2995                 3000             


Glu Ile  Arg Glu Asp Asp Ala  Ala Phe Glu Ala Arg  Val Lys Glu 
    3005                 3010                 3015             


Glu Glu  Gln Lys Ile Phe Gly  Leu Met Val Asp Arg  Gln Ser Gln 
    3020                 3025                 3030             


Gly Thr  Thr Pro Asp Thr Thr  Pro Ala Arg Thr Pro  Thr Glu Glu 
    3035                 3040                 3045             


Gly Thr  Pro Thr Ser Glu Gln  Asn Pro Phe Leu Phe  Gln Glu Gly 
    3050                 3055                 3060             


Lys Leu  Phe Glu Met Thr Arg  Ser Gly Ala Ile Asp  Met Thr Lys 
    3065                 3070                 3075             


Arg Pro  Tyr Ala Asp Glu Ser  Leu His Phe Phe Gln  Ile Gly Gln 
    3080                 3085                 3090             


Glu Ser  Asn Glu Glu Ala Ile  Ser Glu Asp Leu Lys  Glu Gly Ala 
    3095                 3100                 3105             


Thr Gly  Ala Glu Pro Pro Gln  Thr Glu Thr Thr Ser  Glu Ser Leu 
    3110                 3115                 3120             


Glu Leu  Ser Glu Pro Lys Glu  Ala Met Asp Asp Glu  Gly Glu Leu 
    3125                 3130                 3135             


Leu Pro  Asp Asp Val Ser Glu  Glu Ile Glu Asp Leu  Pro Ala Ser 
    3140                 3145                 3150             


Asp Ala  Asn Ile Asp Ser Gln  Val Ile Ile Ser Ala  Ser Thr Glu 
    3155                 3160                 3165             


Thr Pro  Thr Lys Glu Ala Val  Ser Thr Ala Val Glu  Glu Pro Pro 
    3170                 3175                 3180             


Thr Thr  Gln Arg Ser Asp Ser  Leu Ser Thr Val Lys  Gln Thr Pro 
    3185                 3190                 3195             


Arg Pro  Ala Val Pro Gly Pro  Val Gly Gln Leu Asp  Phe Ser Pro 
    3200                 3205                 3210             


Val Thr  Arg Ser Val Tyr Ser  Gly Gln Asp Asp Glu  Ser Pro Glu 
    3215                 3220                 3225             


Ser Ser  Pro Glu Glu Gln Lys  Ser Val Ile Glu Ile  Pro Thr Ala 
    3230                 3235                 3240             


Pro Val  Asp Asn Val Pro Ser  Ala Glu Ser Lys Pro  Gln Ile Pro 
    3245                 3250                 3255             


Ile Arg  Thr Leu Pro Thr Leu  Val Pro Ala Pro Pro  Ser Ala Glu 
    3260                 3265                 3270             


Asp Glu  Ser Ala Phe Ser Asp  Asp Phe Pro Ser Ser  Leu Asp Glu 
    3275                 3280                 3285             


Asp Ser  Lys Glu Gly Gly Ala  Lys Pro Lys Ser Lys  Ile Pro Val 
    3290                 3295                 3300             


Lys Ala  Pro Thr Gln Arg Thr  Glu Trp Gln Pro Ser  Pro Thr Asp 
    3305                 3310                 3315             


Ile Pro  Leu Gln Lys Thr Ala  Val Pro Gln Gly Gln  Glu Thr Leu 
    3320                 3325                 3330             


Ser Arg  Ala Pro Asp Gly Arg  Ser Lys Ser Glu Ser  Asp Ala Ser 
    3335                 3340                 3345             


Ser Leu  Asp Ala Lys Thr Lys  Cys Pro Val Lys Ala  Arg Ser Tyr 
    3350                 3355                 3360             


Ile Glu  Thr Glu Thr Glu Ser  Arg Glu Arg Ala Glu  Gly Phe Glu 
    3365                 3370                 3375             


Ser Glu  Ser Glu Asp Gly Ala  Thr Lys Pro Lys Leu  Phe Ala Ser 
    3380                 3385                 3390             


Arg Leu  Pro Val Lys Ser Arg  Ser Thr Ser Ser Ser  Gly Arg Pro 
    3395                 3400                 3405             


Gly Thr  Ser Pro Thr Arg Glu  Ser Arg Glu His Phe  Phe Asp Leu 
    3410                 3415                 3420             


Tyr Arg  Asn Ser Ile Glu Phe  Phe Glu Glu Ile Ser  Asp Glu Ala 
    3425                 3430                 3435             


Ser Lys  Leu Val Asp Arg Leu  Thr Gln Ser Glu Arg  Glu Gln Glu 
    3440                 3445                 3450             


Pro Pro  Ser Asp Asp Glu Ser  Ser Ser Ala Leu Glu  Val Ser Val 
    3455                 3460                 3465             


Ile Glu  Ser Leu Pro Pro Val  Asp Ile Glu His Ser  Ala Pro Glu 
    3470                 3475                 3480             


Asp Ile  Phe Asp Thr Arg Pro  Ile Trp Asp Glu Ser  Ile Glu Thr 
    3485                 3490                 3495             


Met Ile  Glu Arg Ile Pro Asp  Glu Asn Gly His Asp  Arg Ala Glu 
    3500                 3505                 3510             


Asp Pro  Gln Asp Glu Gln Glu  Arg Met Glu Glu Arg  Leu Ala Tyr 
    3515                 3520                 3525             


Ile Ala  Asp His Leu Gly Phe  Ser Trp Thr Glu Leu  Ala Arg Glu 
    3530                 3535                 3540             


Leu Asp  Phe Thr Glu Glu Gln  Ile His Gln Ile Arg  Ile Glu Asn 
    3545                 3550                 3555             


Pro Asn  Ser Leu Gln Asp Gln  Ser His Ala Leu Leu  Lys Tyr Trp 
    3560                 3565                 3570             


Leu Glu  Arg Asp Gly Lys His  Ala Thr Asp Thr Ile  Leu Ile Glu 
    3575                 3580                 3585             


Cys Leu  Thr Lys Ile Asn Arg  Met Asp Ile Val His  Leu Leu Glu 
    3590                 3595                 3600             


Thr Asn  Thr Glu Pro Leu Gln  Glu Arg Met Gly Arg  Ser Tyr Ala 
    3605                 3610                 3615             


Glu Ile  Glu Gln Thr Ile Thr  Leu Asp His Ser Glu  Gly Phe Ser 
    3620                 3625                 3630             


Val Leu  Pro Asp Glu Leu Cys  Ala Ala Lys Glu Lys  Lys Glu Gln 
    3635                 3640                 3645             


Glu Ala  Ser Lys Glu Ser Glu  Ser Ser Asp His Pro  Pro Met Val 
    3650                 3655                 3660             


Ser Glu  Glu Asp Ile Ser Val  Gly Tyr Ser Thr Phe  Gln Asp Cys 
    3665                 3670                 3675             


Leu Pro  Lys Thr Glu Gly Asp  Ser Pro Ala Ala Ala  Leu Ser Pro 
    3680                 3685                 3690             


Gln Met  His Gln Glu Pro Val  Gln Gln Asp Phe Ser  Gly Lys Thr 
    3695                 3700                 3705             


Gln Asp  Gln Gln Glu Tyr Tyr  Val Thr Thr Pro Gly  Ala Glu Val 
    3710                 3715                 3720             


Glu Asp  Pro Gln Lys Ala Thr  Ala Val Pro Asp Ser  Leu Cys Lys 
    3725                 3730                 3735             


Thr Pro  Glu Asp Ile Ser Thr  Pro Pro Glu Gly Thr  Lys Pro Cys 
    3740                 3745                 3750             


Leu Gln  Thr Pro Val Thr Ser  Glu Arg Gly Ser Pro  Ile Val Gln 
    3755                 3760                 3765             


Glu Pro  Glu Glu Ala Ser Glu  Pro Lys Glu Glu Ser  Ser Pro Arg 
    3770                 3775                 3780             


Lys Thr  Ser Leu Val Ile Val  Glu Ser Thr Asp Asp  Gln Ser Gln 
    3785                 3790                 3795             


Val Phe  Glu Arg Leu Asp Gly  Asp Ala Ala Phe Gln  Lys Gly Asp 
    3800                 3805                 3810             


Asp Met  Pro Asp Ile Pro Pro  Glu Thr Val Thr Glu  Glu Glu Tyr 
    3815                 3820                 3825             


Val Asp  Glu Asn Gly His Thr  Val Val Lys Lys Val  Thr Arg Lys 
    3830                 3835                 3840             


Ile Ile  Arg Arg Tyr Val Ser  Ser Asp Gly Thr Glu  Lys Glu Glu 
    3845                 3850                 3855             


Val Thr  Met Gln Gly Met Pro  Gln Glu Pro Val Asn  Ile Glu Asp 
    3860                 3865                 3870             


Gly Asp  Asn Tyr Ser Lys Val  Ile Lys Arg Val Val  Leu Lys Ser 
    3875                 3880                 3885             


Asp Thr  Gln Gln Ser Glu Asp  Asn Asn Glu 
    3890                 3895             


<210>  29
<211>  933
<212>  PRT
<213>  Mus musculus

<400>  29

Met Val Asp Arg Gln Ser Gln Gly Thr Thr Pro Asp Thr Thr Pro Ala 
1               5                   10                  15      


Arg Thr Pro Thr Glu Glu Gly Thr Pro Thr Ser Glu Gln Asn Pro Phe 
            20                  25                  30          


Leu Phe Gln Glu Gly Lys Leu Phe Glu Met Thr Arg Ser Gly Ala Ile 
        35                  40                  45              


Asp Met Thr Lys Arg Pro Tyr Ala Asp Glu Ser Leu His Phe Phe Gln 
    50                  55                  60                  


Ile Gly Gln Glu Ser Asn Glu Glu Ala Ile Ser Glu Asp Leu Lys Glu 
65                  70                  75                  80  


Gly Ala Thr Gly Ala Glu Pro Pro Gln Thr Glu Thr Thr Ser Glu Ser 
                85                  90                  95      


Leu Glu Leu Ser Glu Pro Lys Glu Ala Met Asp Asp Glu Gly Glu Leu 
            100                 105                 110         


Leu Pro Asp Asp Val Ser Glu Glu Ile Glu Asp Leu Pro Ala Ser Asp 
        115                 120                 125             


Ala Asn Ile Asp Ser Gln Val Ile Ile Ser Ala Ser Thr Glu Thr Pro 
    130                 135                 140                 


Thr Lys Glu Ala Val Ser Thr Ala Val Glu Glu Pro Pro Thr Thr Gln 
145                 150                 155                 160 


Arg Ser Asp Ser Leu Ser Thr Val Lys Gln Thr Pro Arg Pro Ala Val 
                165                 170                 175     


Pro Gly Pro Val Gly Gln Leu Asp Phe Ser Pro Val Thr Arg Ser Val 
            180                 185                 190         


Tyr Ser Gly Gln Asp Asp Glu Ser Pro Glu Ser Ser Pro Glu Glu Gln 
        195                 200                 205             


Lys Ser Val Ile Glu Ile Pro Thr Ala Pro Val Asp Asn Val Pro Ser 
    210                 215                 220                 


Ala Glu Ser Lys Pro Gln Ile Pro Ile Arg Thr Leu Pro Thr Leu Val 
225                 230                 235                 240 


Pro Ala Pro Pro Ser Ala Glu Asp Glu Ser Ala Phe Ser Asp Asp Phe 
                245                 250                 255     


Pro Ser Ser Leu Asp Glu Asp Ser Lys Glu Gly Gly Ala Lys Pro Lys 
            260                 265                 270         


Ser Lys Ile Pro Val Lys Ala Pro Thr Gln Arg Thr Glu Trp Gln Pro 
        275                 280                 285             


Ser Pro Thr Asp Ile Pro Leu Gln Lys Thr Ala Val Pro Gln Gly Gln 
    290                 295                 300                 


Glu Thr Leu Ser Arg Ala Pro Asp Gly Arg Ser Lys Ser Glu Ser Asp 
305                 310                 315                 320 


Ala Ser Ser Leu Asp Ala Lys Thr Lys Cys Pro Val Lys Ala Arg Ser 
                325                 330                 335     


Tyr Ile Glu Thr Glu Thr Glu Ser Arg Glu Arg Ala Glu Gly Phe Glu 
            340                 345                 350         


Ser Glu Ser Glu Asp Gly Ala Thr Lys Pro Lys Leu Phe Ala Ser Arg 
        355                 360                 365             


Leu Pro Val Lys Ser Arg Ser Thr Ser Ser Ser Gly Arg Pro Gly Thr 
    370                 375                 380                 


Ser Pro Thr Arg Glu Ser Arg Glu His Phe Phe Asp Leu Tyr Arg Asn 
385                 390                 395                 400 


Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp Glu Ala Ser Lys Leu Val 
                405                 410                 415     


Asp Arg Leu Thr Gln Ser Glu Arg Glu Gln Glu Pro Pro Ser Asp Asp 
            420                 425                 430         


Glu Ser Ser Ser Ala Leu Glu Val Ser Val Ile Glu Ser Leu Pro Pro 
        435                 440                 445             


Val Asp Ile Glu His Ser Ala Pro Glu Asp Ile Phe Asp Thr Arg Pro 
    450                 455                 460                 


Ile Trp Asp Glu Ser Ile Glu Thr Met Ile Glu Arg Ile Pro Asp Glu 
465                 470                 475                 480 


Asn Gly His Asp Arg Ala Glu Asp Pro Gln Asp Glu Gln Glu Arg Met 
                485                 490                 495     


Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly Phe Ser Trp Thr 
            500                 505                 510         


Glu Leu Ala Arg Glu Leu Asp Phe Thr Glu Glu Gln Ile His Gln Ile 
        515                 520                 525             


Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser His Ala Leu Leu 
    530                 535                 540                 


Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala Thr Asp Thr Ile Leu 
545                 550                 555                 560 


Ile Glu Cys Leu Thr Lys Ile Asn Arg Met Asp Ile Val His Leu Leu 
                565                 570                 575     


Glu Thr Asn Thr Glu Pro Leu Gln Glu Arg Met Gly Arg Ser Tyr Ala 
            580                 585                 590         


Glu Ile Glu Gln Thr Ile Thr Leu Asp His Ser Glu Gly Phe Ser Val 
        595                 600                 605             


Leu Pro Asp Glu Leu Cys Ala Ala Lys Glu Lys Lys Glu Gln Glu Ala 
    610                 615                 620                 


Ser Lys Glu Ser Glu Ser Ser Asp His Pro Pro Met Val Ser Glu Glu 
625                 630                 635                 640 


Asp Ile Ser Val Gly Tyr Ser Thr Phe Gln Asp Cys Leu Pro Lys Thr 
                645                 650                 655     


Glu Gly Asp Ser Pro Ala Ala Ala Leu Ser Pro Gln Met His Gln Glu 
            660                 665                 670         


Pro Val Gln Gln Asp Phe Ser Gly Lys Thr Gln Asp Gln Gln Glu Tyr 
        675                 680                 685             


Tyr Val Thr Thr Pro Gly Ala Glu Val Glu Asp Pro Gln Lys Ala Thr 
    690                 695                 700                 


Ala Val Pro Asp Ser Leu Cys Lys Thr Pro Glu Asp Ile Ser Thr Pro 
705                 710                 715                 720 


Pro Glu Gly Thr Lys Pro Cys Leu Gln Thr Pro Val Thr Ser Glu Arg 
                725                 730                 735     


Gly Ser Pro Ile Val Gln Glu Pro Glu Glu Ala Ser Glu Pro Lys Glu 
            740                 745                 750         


Glu Ser Ser Pro Arg Lys Thr Ser Leu Val Ile Val Glu Ser Thr Asp 
        755                 760                 765             


Asp Gln Ser Gln Val Phe Glu Arg Leu Asp Gly Asp Ala Ala Phe Gln 
    770                 775                 780                 


Lys Gly Asp Asp Met Pro Asp Ile Pro Pro Glu Thr Val Thr Glu Glu 
785                 790                 795                 800 


Glu Tyr Val Asp Glu Asn Gly His Thr Val Val Lys Lys Val Thr Arg 
                805                 810                 815     


Lys Ile Ile Arg Arg Tyr Val Ser Ser Asp Gly Thr Glu Lys Glu Glu 
            820                 825                 830         


Val Thr Met Gln Gly Met Pro Gln Glu Pro Val Asn Ile Glu Asp Gly 
        835                 840                 845             


Asp Asn Tyr Ser Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp Thr 
    850                 855                 860                 


Gln Gln Ser Glu Val Thr Leu Ser Glu Pro Ser Val Leu Ser Ser Thr 
865                 870                 875                 880 


Ser Gln Phe Gln Ala Glu Pro Val Glu Gly Arg Arg Val Ser Lys Val 
                885                 890                 895     


Val Lys Thr Thr Met Val His Gly Glu Arg Met Glu Lys Ser Leu Gly 
            900                 905                 910         


Asp Ser Ser Leu Ala Thr Asp Leu Pro Ser Ala Lys Asp Asp Phe Glu 
        915                 920                 925             


Glu Asp Asn Asn Glu 
    930             


<210>  30
<211>  1050
<212>  PRT
<213>  Mus musculus

<400>  30

Met Thr Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Thr Val 
1               5                   10                  15      


Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu Leu 
            20                  25                  30          


Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn Tyr 
        35                  40                  45              


Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser Phe 
    50                  55                  60                  


Ser Ser Asp Arg Ser His Thr Leu Ser His Ala Ser Tyr Leu Arg Asp 
65                  70                  75                  80  


Ser Ala Met Ile Asp Asp Thr Val Val Ile Pro Ser His Gln Val Ser 
                85                  90                  95      


Ala Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp Gly 
            100                 105                 110         


Thr Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His Ser 
        115                 120                 125             


Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg 
    130                 135                 140                 


Gly Cys Arg His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys 
145                 150                 155                 160 


Thr Ala Pro Thr Arg Val Thr Cys Arg Leu Val Lys Arg His Arg Leu 
                165                 170                 175     


Ala Thr Met Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu 
            180                 185                 190         


Ile Glu Val Gly Pro Ser Gly Ala Gln Phe Leu Gly Pro Val Ile Val 
        195                 200                 205             


Glu Ile Pro His Phe Ala Ala Leu Arg Gly Lys Glu Arg Glu Leu Val 
    210                 215                 220                 


Val Leu Arg Ser Glu Asn Gly Asp Ser Trp Lys Glu His Phe Cys Asp 
225                 230                 235                 240 


Tyr Thr Glu Asp Glu Leu Asn Glu Ile Leu Asn Gly Met Asp Glu Val 
                245                 250                 255     


Leu Asp Ser Pro Glu Asp Leu Glu Lys Lys Arg Ile Cys Arg Ile Ile 
            260                 265                 270         


Thr Arg Asp Phe Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln 
        275                 280                 285             


Asp Ser Asn Leu Ile Gly Pro Glu Gly Gly Val Leu Ser Ser Thr Val 
    290                 295                 300                 


Val Ser Gln Val Gln Ala Val Phe Pro Glu Gly Ala Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Val Gly Leu Gln Ala Gln Pro Met His Ser Glu Leu Val Lys 
                325                 330                 335     


Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile Val Thr Leu Glu 
            340                 345                 350         


Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met Thr Ile Pro Val 
        355                 360                 365             


Pro Lys Ala Ser Ser Asp Val Met Leu Asn Gly Phe Gly Gly Asp Ala 
    370                 375                 380                 


Pro Thr Leu Arg Leu Leu Cys Ser Ile Thr Gly Gly Thr Thr Pro Ala 
385                 390                 395                 400 


Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu Thr Phe Val Asn Glu 
                405                 410                 415     


Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ile Asp 
            420                 425                 430         


Cys Arg Gln Ile Gln Glu Ser Val Ala Phe Ala Ser Gln Val Tyr Arg 
        435                 440                 445             


Glu Ile Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala Lys 
    450                 455                 460                 


Ser His Asp Pro Ile Glu Ala Arg Leu Arg Cys Phe Cys Met Thr Asp 
465                 470                 475                 480 


Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu Asn Phe Ser Glu Val 
                485                 490                 495     


Ala Arg Ser Arg Asp Val Glu Val Leu Glu Gly Lys Pro Ile Tyr Val 
            500                 505                 510         


Asp Cys Phe Gly Asn Leu Val Pro Leu Thr Lys Ser Gly Gln His His 
        515                 520                 525             


Ile Phe Ser Phe Phe Ala Phe Lys Glu Asn Arg Leu Pro Leu Phe Val 
    530                 535                 540                 


Lys Val Arg Asp Thr Thr Gln Glu Pro Cys Gly Arg Leu Ser Phe Met 
545                 550                 555                 560 


Lys Glu Pro Lys Ser Thr Arg Gly Leu Val His Gln Ala Ile Cys Asn 
                565                 570                 575     


Leu Asn Ile Thr Leu Pro Ile Tyr Ala Lys Glu Ser Glu Ser Asp Gln 
            580                 585                 590         


Glu Pro Glu Glu Glu Ile Gly Met Thr Ser Glu Lys Asn Pro Gln Asp 
        595                 600                 605             


Glu Gln Glu Arg Met Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu 
    610                 615                 620                 


Gly Phe Ser Trp Thr Glu Leu Ala Arg Glu Leu Asp Phe Thr Glu Glu 
625                 630                 635                 640 


Gln Ile His Gln Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln 
                645                 650                 655     


Ser His Ala Leu Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala 
            660                 665                 670         


Thr Asp Thr Ile Leu Ile Glu Cys Leu Thr Lys Ile Asn Arg Met Asp 
        675                 680                 685             


Ile Val His Leu Leu Glu Thr Asn Thr Glu Pro Leu Gln Glu Arg Met 
    690                 695                 700                 


Gly Arg Ser Tyr Ala Glu Ile Glu Gln Thr Ile Thr Leu Asp His Ser 
705                 710                 715                 720 


Glu Gly Phe Ser Val Leu Pro Asp Glu Leu Cys Ala Ala Lys Glu Lys 
                725                 730                 735     


Lys Glu Gln Glu Ala Ser Lys Glu Ser Glu Ser Ser Asp His Pro Pro 
            740                 745                 750         


Met Val Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Thr Phe Gln Asp 
        755                 760                 765             


Cys Leu Pro Lys Thr Glu Gly Asp Ser Pro Ala Ala Ala Leu Ser Pro 
    770                 775                 780                 


Gln Met His Gln Glu Pro Val Gln Gln Asp Phe Ser Gly Lys Thr Gln 
785                 790                 795                 800 


Asp Gln Gln Glu Tyr Tyr Val Thr Thr Pro Gly Ala Glu Val Glu Asp 
                805                 810                 815     


Pro Gln Lys Ala Thr Ala Val Pro Asp Ser Leu Cys Lys Thr Pro Glu 
            820                 825                 830         


Asp Ile Ser Thr Pro Pro Glu Gly Thr Lys Pro Cys Leu Gln Thr Pro 
        835                 840                 845             


Val Thr Ser Glu Arg Gly Ser Pro Ile Val Gln Glu Pro Glu Glu Ala 
    850                 855                 860                 


Ser Glu Pro Lys Glu Glu Ser Ser Pro Arg Lys Thr Ser Leu Val Ile 
865                 870                 875                 880 


Val Glu Ser Thr Asp Asp Gln Ser Gln Val Phe Glu Arg Leu Asp Gly 
                885                 890                 895     


Asp Ala Ala Phe Gln Lys Gly Asp Asp Met Pro Asp Ile Pro Pro Glu 
            900                 905                 910         


Thr Val Thr Glu Glu Glu Tyr Val Asp Glu Asn Gly His Thr Val Val 
        915                 920                 925             


Lys Lys Val Thr Arg Lys Ile Ile Arg Arg Tyr Val Ser Ser Asp Gly 
    930                 935                 940                 


Thr Glu Lys Glu Glu Val Thr Met Gln Gly Met Pro Gln Glu Pro Val 
945                 950                 955                 960 


Asn Ile Glu Asp Gly Asp Asn Tyr Ser Lys Val Ile Lys Arg Val Val 
                965                 970                 975     


Leu Lys Ser Asp Thr Gln Gln Ser Glu Val Thr Leu Ser Glu Pro Ser 
            980                 985                 990         


Val Leu Ser Ser Thr Ser Gln Phe  Gln Ala Glu Pro Val  Glu Gly Arg 
        995                 1000                 1005             


Arg Val  Ser Lys Val Val Lys  Thr Thr Met Val His  Gly Glu Arg 
    1010                 1015                 1020             


Met Glu  Lys Ser Leu Gly Asp  Ser Ser Leu Ala Thr  Asp Leu Pro 
    1025                 1030                 1035             


Ser Ala  Lys Asp Asp Phe Glu  Glu Asp Asn Asn Glu  
    1040                 1045                 1050 


<210>  31
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Ala Thr Val Glu Gly Pro Glu Leu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Asp Ala Ser Glu Asp Ser Asp Ala Gly Ser Arg Ala Leu Pro Phe 
            20                  25                  30          


Leu Gly Gly Asn Arg Leu Ser Leu Asp Leu Tyr Pro Gly Gly Cys Gln 
        35                  40                  45              


Gln Leu Leu His Leu Cys Val Gln Gln Pro Leu Gln Leu Leu Gln Val 
    50                  55                  60                  


Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro Gln Leu Leu Glu Ala 
65                  70                  75                  80  


Thr Leu Ala Gln Leu Pro Gln Ser Leu Ser Cys Leu Arg Ser Leu Val 
                85                  90                  95      


Leu Lys Gly Gly Gln Arg Arg Asp Thr Leu Gly Ala Cys Leu Arg Gly 
            100                 105                 110         


Ala Leu Thr Asn Leu Pro Ala Gly Leu Ser Gly Leu Ala His Leu Ala 
        115                 120                 125             


His Leu Asp Leu Ser Phe Asn Ser Leu Glu Thr Leu Pro Ala Cys Val 
    130                 135                 140                 


Leu Gln Met Arg Gly Leu Gly Ala Leu Leu Leu Ser His Asn Cys Leu 
145                 150                 155                 160 


Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro Ala Leu Thr Phe Leu 
                165                 170                 175     


Thr Val Thr His Asn Arg Leu Gln Thr Leu Pro Pro Ala Leu Gly Ala 
            180                 185                 190         


Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Gln Asn Leu Leu Asp Thr 
        195                 200                 205             


Leu Pro Pro Glu Ile Gly Gly Leu Gly Ser Leu Leu Glu Leu Asn Leu 
    210                 215                 220                 


Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser Leu Ala Gly Leu Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu Leu Ala Ser Val Pro 
                245                 250                 255     


Ala Asp Leu Ala Arg Leu Pro Leu Leu Thr Arg Leu Asp Leu Arg Asp 
            260                 265                 270         


Asn Gln Leu Arg Asp Leu Pro Pro Glu Leu Leu Asp Ala Pro Phe Val 
        275                 280                 285             


Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser Pro Asp Ala Pro Ser 
    290                 295                 300                 


Ser Pro Val Ala Ala Leu Ile Pro Glu Met Pro Arg Leu Phe Leu Thr 
305                 310                 315                 320 


Ser Asp Leu Asp Ser Phe Pro Val Thr Pro Gln Gly Cys Ser Val Thr 
                325                 330                 335     


Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala Gly Ala Thr Ala Thr 
            340                 345                 350         


Pro Ile Thr Ile Arg Tyr Arg Leu Leu Leu Pro Glu Pro Gly Leu Val 
        355                 360                 365             


Pro Leu Gly Pro His Asp Ala Leu Leu Ser His Val Leu Glu Leu Gln 
    370                 375                 380                 


Pro His Gly Val Ala Phe Gln Gln Asp Val Gly Leu Trp Leu Leu Phe 
385                 390                 395                 400 


Thr Pro Pro Gln Ala Arg Arg Cys Arg Glu Val Val Val Arg Thr Arg 
                405                 410                 415     


Asn Asp Asn Ser Trp Gly Asp Leu Glu Thr Tyr Leu Glu Glu Glu Ala 
            420                 425                 430         


Pro Gln Arg Leu Trp Ala His Cys Gln Val Pro His Phe Ser Trp Phe 
        435                 440                 445             


Leu Val Val Ser Arg Pro Val Ser Asn Ala Cys Leu Val Pro Pro Glu 
    450                 455                 460                 


Gly Thr Leu Leu Cys Ser Ser Gly His Pro Gly Val Lys Val Ile Phe 
465                 470                 475                 480 


Pro Pro Gly Ala Thr Glu Glu Pro Arg Arg Val Ser Met Gln Val Val 
                485                 490                 495     


Arg Met Ala Gly Arg Glu Leu Gln Ala Leu Leu Gly Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ser Pro Leu Leu Cys Leu Ser Gln Ser Gly Pro Pro Ser Phe 
        515                 520                 525             


Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro Ser Gly Ile Thr Gly 
    530                 535                 540                 


Leu Ser Leu Asp Arg Ser Arg Leu His Leu Leu Tyr Trp Ala Pro Pro 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Asp Ile Thr Ala Gln Val Val Leu Glu Leu Thr 
                565                 570                 575     


His Leu Tyr Ala Arg Phe Gln Val Thr His Phe Ser Trp Tyr Trp Leu 
            580                 585                 590         


Trp Tyr Thr Thr Lys Asn Cys Val Gly Gly Leu Ala Arg Lys Ala Trp 
        595                 600                 605             


Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile Ala Leu Gln Arg Arg 
    610                 615                 620                 


Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu Pro Arg Asn Lys Val 
625                 630                 635                 640 


Asp Ala Thr Leu Arg Arg Leu Leu Glu Arg Tyr Arg Gly Pro Glu Pro 
                645                 650                 655     


Ser Asp Thr Val Glu Met Phe Glu Gly Glu Glu Phe Phe Ala Ala Phe 
            660                 665                 670         


Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro Asp Cys Val Glu Gly 
        675                 680                 685             


Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys Asn Val Lys Glu Val 
    690                 695                 700                 


Tyr Val Thr Thr Thr Leu Asp Arg Glu Ala Gln Ala Val Arg Gly Gln 
705                 710                 715                 720 


Val Ser Phe Tyr Arg Gly Ala Val Pro Val Arg Val Pro Glu Glu Ala 
                725                 730                 735     


Glu Ala Ala Arg Gln Arg Lys Gly Ala Asp Ala Leu Trp Met Ala Thr 
            740                 745                 750         


Leu Pro Ile Lys Leu Pro Arg Leu Arg Gly Ser Glu Gly Pro Arg Arg 
        755                 760                 765             


Gly Ala Gly Leu Ser Leu Ala Pro Leu Asn Leu Gly Asp Ala Glu Thr 
    770                 775                 780                 


Gly Phe Leu Thr Gln Ser Asn Leu Leu Ser Val Ala Gly Arg Leu Gly 
785                 790                 795                 800 


Leu Asp Trp Pro Ala Val Ala Leu His Leu Gly Val Ser Tyr Arg Glu 
                805                 810                 815     


Val Gln Arg Ile Arg His Glu Phe Arg Asp Asp Leu Asp Glu Gln Ile 
            820                 825                 830         


Arg His Met Leu Phe Ser Trp Ala Glu Arg Gln Ala Gly Gln Pro Gly 
        835                 840                 845             


Ala Val Gly Leu Leu Val Gln Ala Leu Glu Gln Ser Asp Arg Gln Asp 
    850                 855                 860                 


Val Ala Glu Glu Val Arg Ala Val Leu Glu Leu Gly Arg Arg Lys Tyr 
865                 870                 875                 880 


Gln Asp Ser Ile Arg Arg Met Gly Leu Ala Pro Lys Asp Pro Ala Leu 
                885                 890                 895     


Pro Gly Ser Ser Ala Pro Gln Pro Pro Glu Pro Ala Gln Ala 
            900                 905                 910 


<210>  32
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Thr Val Glu Gly Pro Glu Leu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Asp Ala Ser Glu Asp Ser Asp Ala Gly Ser Arg Ala Leu Pro Phe 
            20                  25                  30          


Leu Gly Gly Asn Arg Leu Ser Leu Asp Leu Tyr Pro Gly Gly Cys Gln 
        35                  40                  45              


Gln Leu Leu His Leu Cys Val Gln Gln Pro Leu Gln Leu Leu Gln Val 
    50                  55                  60                  


Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro Gln Leu Leu Glu Ala 
65                  70                  75                  80  


Thr Leu Ala Gln Leu Pro Gln Ser Leu Ser Cys Leu Arg Ser Leu Val 
                85                  90                  95      


Leu Lys Gly Gly Gln Arg Arg Asp Thr Leu Gly Ala Cys Leu Arg Gly 
            100                 105                 110         


Ala Leu Thr Asn Leu Pro Ala Gly Leu Ser Gly Leu Ala His Leu Ala 
        115                 120                 125             


His Leu Asp Leu Ser Phe Asn Ser Leu Glu Thr Leu Pro Ala Cys Val 
    130                 135                 140                 


Leu Gln Met Arg Gly Leu Gly Ala Leu Leu Leu Ser His Asn Cys Leu 
145                 150                 155                 160 


Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro Ala Leu Thr Phe Leu 
                165                 170                 175     


Thr Val Thr His Asn Arg Leu Gln Thr Leu Pro Pro Ala Leu Gly Ala 
            180                 185                 190         


Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Gln Asn Leu Leu Asp Thr 
        195                 200                 205             


Leu Pro Pro Glu Ile Gly Gly Leu Gly Ser Leu Leu Glu Leu Asn Leu 
    210                 215                 220                 


Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser Leu Ala Gly Leu Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu Leu Ala Ser Val Pro 
                245                 250                 255     


Ala Asp Leu Ala Arg Leu Pro Leu Leu Thr Arg Leu Asp Leu Arg Asp 
            260                 265                 270         


Asn Gln Leu Arg Asp Leu Pro Pro Glu Leu Leu Asp Ala Pro Phe Val 
        275                 280                 285             


Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser Pro Asp Ala Pro Ser 
    290                 295                 300                 


Ser Pro Val Ala Ala Leu Ile Pro Glu Met Pro Arg Leu Phe Leu Thr 
305                 310                 315                 320 


Ser Asp Leu Asp Ser Phe Pro Val Thr Pro Gln Gly Cys Ser Val Thr 
                325                 330                 335     


Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala Gly Ala Thr Ala Thr 
            340                 345                 350         


Pro Ile Thr Ile Arg Tyr Arg Leu Leu Leu Pro Glu Pro Gly Leu Val 
        355                 360                 365             


Pro Leu Gly Pro His Asp Ala Leu Leu Ser His Val Leu Glu Leu Gln 
    370                 375                 380                 


Pro His Gly Val Ala Phe Gln Gln Asp Val Gly Leu Trp Leu Leu Phe 
385                 390                 395                 400 


Thr Pro Pro Gln Ala Arg Arg Cys Arg Glu Val Val Val Arg Thr Arg 
                405                 410                 415     


Asn Asp Asn Ser Trp Gly Asp Leu Glu Thr Tyr Leu Glu Glu Glu Ala 
            420                 425                 430         


Pro Gln Arg Leu Trp Ala His Cys Gln Val Pro His Phe Ser Trp Phe 
        435                 440                 445             


Leu Val Val Ser Arg Pro Val Ser Asn Ala Cys Leu Val Pro Pro Glu 
    450                 455                 460                 


Gly Thr Leu Leu Cys Ser Ser Gly His Pro Gly Val Lys Val Ile Phe 
465                 470                 475                 480 


Pro Pro Gly Ala Thr Glu Glu Pro Arg Arg Val Ser Met Gln Val Val 
                485                 490                 495     


Arg Met Ala Gly Arg Glu Leu Gln Ala Leu Leu Gly Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ser Pro Leu Leu Cys Leu Ser Gln Ser Gly Pro Pro Ser Phe 
        515                 520                 525             


Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro Ser Gly Ile Thr Gly 
    530                 535                 540                 


Leu Ser Leu Asp Arg Ser Arg Leu His Leu Leu Tyr Trp Ala Pro Pro 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Asp Ile Thr Ala Gln Val Val Leu Glu Leu Thr 
                565                 570                 575     


His Leu Tyr Ala Arg Phe Gln Val Thr His Phe Ser Trp Tyr Trp Leu 
            580                 585                 590         


Trp Tyr Thr Thr Lys Asn Cys Val Gly Gly Leu Ala Arg Lys Ala Trp 
        595                 600                 605             


Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile Ala Leu Gln Arg Arg 
    610                 615                 620                 


Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu Pro Arg Asn Lys Val 
625                 630                 635                 640 


Asp Ala Thr Leu Arg Arg Leu Leu Glu Arg Tyr Arg Gly Pro Glu Pro 
                645                 650                 655     


Ser Asp Thr Val Glu Met Phe Glu Gly Glu Glu Phe Phe Ala Ala Phe 
            660                 665                 670         


Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro Asp Cys Val Glu Gly 
        675                 680                 685             


Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys Asn Val Lys Glu Val 
    690                 695                 700                 


Tyr Val Thr Thr Thr Leu Asp Arg Glu Ala Gln Ala Val Arg Gly Gln 
705                 710                 715                 720 


Val Ser Phe Tyr Arg Gly Ala Val Pro Val Arg Val Pro Glu Glu Ala 
                725                 730                 735     


Glu Ala Ala Arg Gln Arg Lys Gly Ala Asp Ala Leu Trp Met Ala Thr 
            740                 745                 750         


Leu Pro Ile Lys Leu Pro Arg Leu Arg Gly Ser Glu Gly Pro Arg Arg 
        755                 760                 765             


Gly Ala Gly Leu Ser Leu Ala Pro Leu Asn Leu Gly Asp Ala Glu Thr 
    770                 775                 780                 


Gly Phe Leu Thr Gln Ser Asn Leu Leu Ser Val Ala Gly Arg Leu Gly 
785                 790                 795                 800 


Leu Asp Trp Pro Ala Val Ala Leu His Leu Gly Val Ser Tyr Arg Glu 
                805                 810                 815     


Val Gln Arg Ile Arg His Glu Phe Arg Asp Asp Leu Asp Glu Gln Ile 
            820                 825                 830         


Arg His Met Leu Phe Ser Trp Ala Glu Arg Gln Ala Gly Gln Pro Gly 
        835                 840                 845             


Ala Val Gly Leu Leu Val Gln Ala Leu Glu Gln Ser Asp Arg Gln Asp 
    850                 855                 860                 


Val Ala Glu Glu Val Arg Ala Val Leu Glu Leu Gly Arg Arg Lys Tyr 
865                 870                 875                 880 


Gln Asp Ser Ile Arg Arg Met Gly Leu Ala Pro Lys Asp Pro Ala Leu 
                885                 890                 895     


Pro Gly Ser Ser Ala Pro Gln Pro Pro Glu Pro Ala Gln Ala 
            900                 905                 910 


<210>  33
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Thr Val Glu Gly Pro Glu Leu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Asp Ala Ser Glu Asp Ser Asp Ala Gly Ser Arg Ala Leu Pro Phe 
            20                  25                  30          


Leu Gly Gly Asn Arg Leu Ser Leu Asp Leu Tyr Pro Gly Gly Cys Gln 
        35                  40                  45              


Gln Leu Leu His Leu Cys Val Gln Gln Pro Leu Gln Leu Leu Gln Val 
    50                  55                  60                  


Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro Gln Leu Leu Glu Ala 
65                  70                  75                  80  


Thr Leu Ala Gln Leu Pro Gln Ser Leu Ser Cys Leu Arg Ser Leu Val 
                85                  90                  95      


Leu Lys Gly Gly Gln Arg Arg Asp Thr Leu Gly Ala Cys Leu Arg Gly 
            100                 105                 110         


Ala Leu Thr Asn Leu Pro Ala Gly Leu Ser Gly Leu Ala His Leu Ala 
        115                 120                 125             


His Leu Asp Leu Ser Phe Asn Ser Leu Glu Thr Leu Pro Ala Cys Val 
    130                 135                 140                 


Leu Gln Met Arg Gly Leu Gly Ala Leu Leu Leu Ser His Asn Cys Leu 
145                 150                 155                 160 


Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro Ala Leu Thr Phe Leu 
                165                 170                 175     


Thr Val Thr His Asn Arg Leu Gln Thr Leu Pro Pro Ala Leu Gly Ala 
            180                 185                 190         


Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Gln Asn Leu Leu Asp Thr 
        195                 200                 205             


Leu Pro Pro Glu Ile Gly Gly Leu Gly Ser Leu Leu Glu Leu Asn Leu 
    210                 215                 220                 


Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser Leu Ala Gly Leu Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu Leu Ala Ser Val Pro 
                245                 250                 255     


Ala Asp Leu Ala Arg Leu Pro Leu Leu Thr Arg Leu Asp Leu Arg Asp 
            260                 265                 270         


Asn Gln Leu Arg Asp Leu Pro Pro Glu Leu Leu Asp Ala Pro Phe Val 
        275                 280                 285             


Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser Pro Asp Ala Pro Ser 
    290                 295                 300                 


Ser Pro Val Ala Ala Leu Ile Pro Glu Met Pro Arg Leu Phe Leu Thr 
305                 310                 315                 320 


Ser Asp Leu Asp Ser Phe Pro Val Thr Pro Gln Gly Cys Ser Val Thr 
                325                 330                 335     


Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala Gly Ala Thr Ala Thr 
            340                 345                 350         


Pro Ile Thr Ile Arg Tyr Arg Leu Leu Leu Pro Glu Pro Gly Leu Val 
        355                 360                 365             


Pro Leu Gly Pro His Asp Ala Leu Leu Ser His Val Leu Glu Leu Gln 
    370                 375                 380                 


Pro His Gly Val Ala Phe Gln Gln Asp Val Gly Leu Trp Leu Leu Phe 
385                 390                 395                 400 


Thr Pro Pro Gln Ala Arg Arg Cys Arg Glu Val Val Val Arg Thr Arg 
                405                 410                 415     


Asn Asp Asn Ser Trp Gly Asp Leu Glu Thr Tyr Leu Glu Glu Glu Ala 
            420                 425                 430         


Pro Gln Arg Leu Trp Ala His Cys Gln Val Pro His Phe Ser Trp Phe 
        435                 440                 445             


Leu Val Val Ser Arg Pro Val Ser Asn Ala Cys Leu Val Pro Pro Glu 
    450                 455                 460                 


Gly Thr Leu Leu Cys Ser Ser Gly His Pro Gly Val Lys Val Ile Phe 
465                 470                 475                 480 


Pro Pro Gly Ala Thr Glu Glu Pro Arg Arg Val Ser Met Gln Val Val 
                485                 490                 495     


Arg Met Ala Gly Arg Glu Leu Gln Ala Leu Leu Gly Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ser Pro Leu Leu Cys Leu Ser Gln Ser Gly Pro Pro Ser Phe 
        515                 520                 525             


Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro Ser Gly Ile Thr Gly 
    530                 535                 540                 


Leu Ser Leu Asp Arg Ser Arg Leu His Leu Leu Tyr Trp Ala Pro Pro 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Asp Ile Thr Ala Gln Val Val Leu Glu Leu Thr 
                565                 570                 575     


His Leu Tyr Ala Arg Phe Gln Val Thr His Phe Ser Trp Tyr Trp Leu 
            580                 585                 590         


Trp Tyr Thr Thr Lys Asn Cys Val Gly Gly Leu Ala Arg Lys Ala Trp 
        595                 600                 605             


Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile Ala Leu Gln Arg Arg 
    610                 615                 620                 


Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu Pro Arg Asn Lys Val 
625                 630                 635                 640 


Asp Ala Thr Leu Arg Arg Leu Leu Glu Arg Tyr Arg Gly Pro Glu Pro 
                645                 650                 655     


Ser Asp Thr Val Glu Met Phe Glu Gly Glu Glu Phe Phe Ala Ala Phe 
            660                 665                 670         


Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro Asp Cys Val Glu Gly 
        675                 680                 685             


Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys Asn Val Lys Glu Val 
    690                 695                 700                 


Ser Phe Tyr Arg Gly Ala Val Pro Val Arg Val Pro Glu Glu Ala Glu 
705                 710                 715                 720 


Ala Ala Arg Gln Arg Lys Gly Ala Asp Ala Leu Trp Met Ala Thr Leu 
                725                 730                 735     


Pro Ile Lys Leu Pro Arg Leu Arg Gly Ser Glu Gly Pro Arg Arg Gly 
            740                 745                 750         


Ala Gly Leu Ser Leu Ala Pro Leu Asn Leu Gly Asp Ala Glu Thr Gly 
        755                 760                 765             


Phe Leu Thr Gln Ser Asn Leu Leu Ser Val Ala Gly Arg Leu Gly Leu 
    770                 775                 780                 


Asp Trp Pro Ala Val Ala Leu His Leu Gly Val Ser Tyr Arg Glu Val 
785                 790                 795                 800 


Gln Arg Ile Arg His Glu Phe Arg Asp Asp Leu Asp Glu Gln Ile Arg 
                805                 810                 815     


His Met Leu Phe Ser Trp Ala Glu Arg Gln Ala Gly Gln Pro Gly Ala 
            820                 825                 830         


Val Gly Leu Leu Val Gln Ala Leu Glu Gln Ser Asp Arg Gln Asp Val 
        835                 840                 845             


Ala Glu Glu Val Arg Ala Val Leu Glu Leu Gly Arg Arg Lys Tyr Gln 
    850                 855                 860                 


Asp Ser Ile Arg Arg Met Gly Leu Ala Pro Lys Asp Pro Ala Leu Pro 
865                 870                 875                 880 


Gly Ser Ser Ala Pro Gln Pro Pro Glu Pro Ala Gln Ala 
                885                 890             


<210>  34
<211>  915
<212>  PRT
<213>  Mus musculus

<400>  34

Met Ala Ala Val Leu Glu Gly Gln Glu Pro Glu Glu Thr Ala Ala Ala 
1               5                   10                  15      


Ala Glu Asp Ala Ala Thr Ser Thr Leu Glu Ala Val Asp Ala Gly Pro 
            20                  25                  30          


Gly Ala Pro Phe Leu Pro Ala Gly Asn Gln Leu Asn Leu Asp Leu Arg 
        35                  40                  45              


Pro Gly Gly Cys His Arg Leu Gln Tyr Leu Cys Ser Gln Gln Pro Pro 
    50                  55                  60                  


Gln Leu Leu Gln Val Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro 
65                  70                  75                  80  


Gln Leu Leu Asp Asp Thr Leu Ala Lys Val Pro Trp Ser Leu Leu Arg 
                85                  90                  95      


Leu Arg Ser Leu Val Leu Lys Gly Gly Gln Ser Arg Gly Ala Leu Gly 
            100                 105                 110         


Ala Cys Leu His Gly Thr Leu Thr Thr Leu Pro Ala Gly Leu Ser Asp 
        115                 120                 125             


Leu Ala Cys Leu Ala His Leu Asp Leu Ser Phe Asn Arg Leu Glu Thr 
    130                 135                 140                 


Leu Pro Thr Cys Val Pro Glu Leu His Gly Leu Asp Ala Leu Leu Leu 
145                 150                 155                 160 


Ser His Asn His Leu Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro 
                165                 170                 175     


Ala Leu Thr Phe Leu Thr Val Thr His Asn Arg Leu Glu Arg Leu Pro 
            180                 185                 190         


Leu Thr Leu Gly Ser Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Glu 
        195                 200                 205             


Asn Leu Leu Asp Thr Ile Pro Ser Glu Ile Gly Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ser Glu Leu Asn Leu Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser 
225                 230                 235                 240 


Leu Ala Gly Leu Arg Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu 
                245                 250                 255     


Leu Thr Ser Val Pro Thr Gly Leu Val His Leu Pro Leu Ile Thr Arg 
            260                 265                 270         


Leu Asp Leu Arg Asp Asn Arg Leu Arg Asp Leu Pro Ala Glu Leu Leu 
        275                 280                 285             


Asp Ala Pro Phe Val Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser 
    290                 295                 300                 


Pro Ala Pro Pro Ser Pro Pro Asp Ile Ser Gln Val Pro Glu Met Pro 
305                 310                 315                 320 


Arg Leu Leu Leu Thr Ser Asp Leu Asp Ser Phe Leu Val Thr Pro His 
                325                 330                 335     


Gly Cys Ser Val Thr Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala 
            340                 345                 350         


Gly Ala Thr Thr Thr Pro Val Thr Ile His Tyr Arg Leu Trp Leu Pro 
        355                 360                 365             


Glu Pro Gly Leu Val Ser Leu Gly Pro His Asp Phe Leu Leu Ser Ser 
    370                 375                 380                 


Val Leu Glu Leu Gln Pro His Gly Val Ala Phe Gln Gln Asp Val Ser 
385                 390                 395                 400 


Leu Trp Leu Leu Phe Val Pro Pro Arg Val Arg Arg Cys Arg Glu Val 
                405                 410                 415     


Val Val Arg Thr Arg Ser Asn Asn Thr Trp Asn Asp Leu Glu Thr Gln 
            420                 425                 430         


Leu Glu Glu Glu Ala Pro Lys Arg Leu Trp Ala Arg Cys Gln Val Pro 
        435                 440                 445             


His Phe Ser Trp Phe Leu Val Val Leu Arg Pro Val Ser Asn Thr Cys 
    450                 455                 460                 


Leu Leu Pro Pro Glu Gly Ala Leu Leu Cys Ser Ser Gly His Pro Gly 
465                 470                 475                 480 


Val Arg Val Thr Phe Pro Pro Gly Val Thr Glu Glu Pro Arg Gln Val 
                485                 490                 495     


Ser Met Gln Val Val His Met Ala Gly Leu Glu Leu Arg Thr Leu Leu 
            500                 505                 510         


Glu Glu Ser Glu Ala Ser Val Ser Pro Leu Leu Cys Leu Ser Gln Ser 
        515                 520                 525             


Gly Pro Pro Ser Phe Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro 
    530                 535                 540                 


Pro Gly Val Thr Gly Phe Ser Leu Asp Arg Ser His Leu His Leu Leu 
545                 550                 555                 560 


Tyr Arg Thr Pro Leu Thr Thr Thr Trp Asp Asp Ile Thr Thr Gln Val 
                565                 570                 575     


Ala Leu Glu Phe Thr His Leu Tyr Ala Arg Phe Gln Val Thr His Phe 
            580                 585                 590         


Ser Trp Tyr Trp Leu Trp Tyr Thr Thr Lys Thr Cys Val Gly Gly Leu 
        595                 600                 605             


Ala Arg Lys Ala Trp Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile 
    610                 615                 620                 


Ala Leu Gln Arg Arg Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu 
625                 630                 635                 640 


Pro Arg Asn Lys Val Asp Ala Thr Leu Ser Arg Leu Leu Val Arg Tyr 
                645                 650                 655     


Arg Gly Pro Glu Pro Ser Glu Thr Val Glu Met Phe Glu Gly Glu Lys 
            660                 665                 670         


Phe Phe Ala Ala Phe Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro 
        675                 680                 685             


Asp Cys Val Asp Gly Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys 
    690                 695                 700                 


Asn Val Lys Glu Val Tyr Ile Thr Thr Ala Leu Asp Arg Glu Ala Gln 
705                 710                 715                 720 


Asp Val Arg Gly Gln Val Ser Phe Tyr Arg Gly Ser Leu Pro Val Glu 
                725                 730                 735     


Val Pro Ala Glu Ala Glu Ala Ala Arg Gln Arg Lys Gly Thr Asp Ala 
            740                 745                 750         


Leu Trp Met Ala Thr Leu Pro Ile Lys Leu Pro Arg Leu Arg Gly Ala 
        755                 760                 765             


Gln Gly Ser Gly Gln Gly Thr Asp Phe Ser Leu Met Pro Leu Asn Leu 
    770                 775                 780                 


Gly Asp Ala Glu Thr Gly Phe Leu Thr Gln Ser Asn Leu Leu Ser Val 
785                 790                 795                 800 


Ala Ser Arg Leu Gly Pro Asp Trp Pro Ala Val Ala Leu His Leu Gly 
                805                 810                 815     


Met Pro Tyr His Lys Leu Gln Arg Ile Arg His Glu Phe Arg Asp Asp 
            820                 825                 830         


Leu Asp Gly Gln Val Arg His Met Leu Phe Ser Trp Ala Glu Arg Gln 
        835                 840                 845             


Thr Gly Gln Pro Gly Ala Val Gly His Leu Val Gln Ala Leu Glu Gln 
    850                 855                 860                 


Ser Asp Arg Arg Asp Val Ala Glu Glu Val Arg Ala Ile Leu Glu Leu 
865                 870                 875                 880 


Gly Arg His Lys Tyr Gln Asp Ser Ile Arg Arg Thr Gly Leu Ala Pro 
                885                 890                 895     


Glu Asp Ser Thr Leu Pro Gly Thr Ser Ala Ser Gln Thr Pro Glu Ser 
            900                 905                 910         


Ala Gln Ala 
        915 


<210>  35
<211>  915
<212>  PRT
<213>  Mus musculus

<400>  35

Met Ala Ala Val Leu Glu Gly Gln Glu Pro Glu Glu Thr Ala Ala Ala 
1               5                   10                  15      


Ala Glu Asp Ala Ala Thr Ser Thr Leu Glu Ala Val Asp Ala Gly Pro 
            20                  25                  30          


Gly Ala Pro Phe Leu Pro Ala Gly Asn Gln Leu Asn Leu Asp Leu Arg 
        35                  40                  45              


Pro Gly Gly Cys His Arg Leu Gln Tyr Leu Cys Ser Gln Gln Pro Pro 
    50                  55                  60                  


Gln Leu Leu Gln Val Glu Phe Leu Arg Leu Ser Thr His Glu Asp Pro 
65                  70                  75                  80  


Gln Leu Leu Asp Asp Thr Leu Ala Lys Val Pro Trp Ser Leu Leu Arg 
                85                  90                  95      


Leu Arg Ser Leu Val Leu Lys Gly Gly Gln Ser Arg Gly Ala Leu Gly 
            100                 105                 110         


Ala Cys Leu His Gly Thr Leu Thr Thr Leu Pro Ala Gly Leu Ser Asp 
        115                 120                 125             


Leu Ala Cys Leu Ala His Leu Asp Leu Ser Phe Asn Arg Leu Glu Thr 
    130                 135                 140                 


Leu Pro Thr Cys Val Pro Glu Leu His Gly Leu Asp Ala Leu Leu Leu 
145                 150                 155                 160 


Ser His Asn His Leu Ser Glu Leu Pro Glu Ala Leu Gly Ala Leu Pro 
                165                 170                 175     


Ala Leu Thr Phe Leu Thr Val Thr His Asn Arg Leu Glu Arg Leu Pro 
            180                 185                 190         


Leu Thr Leu Gly Ser Leu Ser Thr Leu Gln Arg Leu Asp Leu Ser Glu 
        195                 200                 205             


Asn Leu Leu Asp Thr Ile Pro Ser Glu Ile Gly Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ser Glu Leu Asn Leu Ala Ser Asn Arg Leu Gln Ser Leu Pro Ala Ser 
225                 230                 235                 240 


Leu Ala Gly Leu Arg Ser Leu Arg Leu Leu Val Leu His Ser Asn Leu 
                245                 250                 255     


Leu Thr Ser Val Pro Thr Gly Leu Val His Leu Pro Leu Ile Thr Arg 
            260                 265                 270         


Leu Asp Leu Arg Asp Asn Arg Leu Arg Asp Leu Pro Ala Glu Leu Leu 
        275                 280                 285             


Asp Ala Pro Phe Val Arg Leu Gln Gly Asn Pro Leu Gly Glu Ala Ser 
    290                 295                 300                 


Pro Ala Pro Pro Ser Pro Pro Asp Ile Ser Gln Val Pro Glu Met Pro 
305                 310                 315                 320 


Arg Leu Leu Leu Thr Ser Asp Leu Asp Ser Phe Leu Val Thr Pro His 
                325                 330                 335     


Gly Cys Ser Val Thr Leu Ala Cys Gly Val Arg Leu Gln Phe Pro Ala 
            340                 345                 350         


Gly Ala Thr Thr Thr Pro Val Thr Ile His Tyr Arg Leu Trp Leu Pro 
        355                 360                 365             


Glu Pro Gly Leu Val Ser Leu Gly Pro His Asp Phe Leu Leu Ser Ser 
    370                 375                 380                 


Val Leu Glu Leu Gln Pro His Gly Val Ala Phe Gln Gln Asp Val Ser 
385                 390                 395                 400 


Leu Trp Leu Leu Phe Val Pro Pro Arg Val Arg Arg Cys Arg Glu Val 
                405                 410                 415     


Val Val Arg Thr Arg Ser Asn Asn Thr Trp Asn Asp Leu Glu Thr Gln 
            420                 425                 430         


Leu Glu Glu Glu Ala Pro Lys Arg Leu Trp Ala Arg Cys Gln Val Pro 
        435                 440                 445             


His Phe Ser Trp Phe Leu Val Val Leu Arg Pro Val Ser Asn Thr Cys 
    450                 455                 460                 


Leu Leu Pro Pro Glu Gly Ala Leu Leu Cys Ser Ser Gly His Pro Gly 
465                 470                 475                 480 


Val Arg Val Thr Phe Pro Pro Gly Val Thr Glu Glu Pro Arg Gln Val 
                485                 490                 495     


Ser Met Gln Val Val His Met Ala Gly Leu Glu Leu Arg Thr Leu Leu 
            500                 505                 510         


Glu Glu Ser Glu Ala Ser Val Ser Pro Leu Leu Cys Leu Ser Gln Ser 
        515                 520                 525             


Gly Pro Pro Ser Phe Leu Gln Pro Val Thr Val Gln Leu Pro Leu Pro 
    530                 535                 540                 


Pro Gly Val Thr Gly Phe Ser Leu Asp Arg Ser His Leu His Leu Leu 
545                 550                 555                 560 


Tyr Arg Thr Pro Leu Thr Thr Thr Trp Asp Asp Ile Thr Thr Gln Val 
                565                 570                 575     


Ala Leu Glu Phe Thr His Leu Tyr Ala Arg Phe Gln Val Thr His Phe 
            580                 585                 590         


Ser Trp Tyr Trp Leu Trp Tyr Thr Thr Lys Thr Cys Val Gly Gly Leu 
        595                 600                 605             


Ala Arg Lys Ala Trp Glu Arg Leu Arg Leu His Arg Val Asn Leu Ile 
    610                 615                 620                 


Ala Leu Gln Arg Arg Arg Asp Pro Glu Gln Val Leu Leu Gln Cys Leu 
625                 630                 635                 640 


Pro Arg Asn Lys Val Asp Ala Thr Leu Ser Arg Leu Leu Val Arg Tyr 
                645                 650                 655     


Arg Gly Pro Glu Pro Ser Glu Thr Val Glu Met Phe Glu Gly Glu Lys 
            660                 665                 670         


Phe Phe Ala Ala Phe Glu Arg Gly Ile Asp Val Asp Ala Asp Arg Pro 
        675                 680                 685             


Asp Cys Val Asp Gly Arg Ile Cys Phe Val Phe Tyr Ser His Leu Lys 
    690                 695                 700                 


Asn Val Lys Glu Val Tyr Ile Thr Thr Ala Leu Asp Arg Glu Ala Gln 
705                 710                 715                 720 


Asp Val Arg Gly Gln Val Ser Phe Tyr Arg Gly Ser Leu Pro Val Glu 
                725                 730                 735     


Val Pro Ala Glu Ala Glu Ala Ala Arg Gln Arg Lys Gly Thr Asp Ala 
            740                 745                 750         


Leu Trp Met Ala Thr Leu Pro Ile Lys Leu Pro Arg Leu Arg Gly Ala 
        755                 760                 765             


Gln Gly Ser Gly Gln Gly Thr Asp Phe Ser Leu Met Pro Leu Asn Leu 
    770                 775                 780                 


Gly Asp Ala Glu Thr Gly Phe Leu Thr Gln Ser Asn Leu Leu Ser Val 
785                 790                 795                 800 


Ala Ser Arg Leu Gly Pro Asp Trp Pro Ala Val Ala Leu His Leu Gly 
                805                 810                 815     


Met Pro Tyr His Lys Leu Gln Arg Ile Arg His Glu Phe Arg Asp Asp 
            820                 825                 830         


Leu Asp Gly Gln Val Arg His Met Leu Phe Ser Trp Ala Glu Arg Gln 
        835                 840                 845             


Thr Gly Gln Pro Gly Ala Val Gly His Leu Val Gln Ala Leu Glu Gln 
    850                 855                 860                 


Ser Asp Arg Arg Asp Val Ala Glu Glu Val Arg Ala Ile Leu Glu Leu 
865                 870                 875                 880 


Gly Arg His Lys Tyr Gln Asp Ser Ile Arg Arg Thr Gly Leu Ala Pro 
                885                 890                 895     


Glu Asp Ser Thr Leu Pro Gly Thr Ser Ala Ser Gln Thr Pro Glu Ser 
            900                 905                 910         


Ala Gln Ala 
        915 


<210>  36
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Cys Pro Gln Glu Ser Ser Phe Gln Pro Ser Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Val Pro Val Ala Ser Val Leu Leu Leu Ala Gln Cys Leu Arg 
            20                  25                  30          


Trp His Cys Pro Arg Arg Leu Leu Gly Ala Cys Trp Thr Leu Asn Gly 
        35                  40                  45              


Gln Glu Glu Pro Val Ser Gln Pro Thr Pro Gln Leu Glu Asn Glu Val 
    50                  55                  60                  


Ser Arg Gln His Leu Pro Ala Thr Leu Pro Glu Met Val Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Thr Pro Thr Gln Gly Gln Thr Met Val Arg Gln Leu 
                85                  90                  95      


Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Ala Val Gly Arg Gln Glu Arg Val Ser Leu Ile Leu Val 
    130                 135                 140                 


Trp Asp Leu Ser Asp Ala Pro Ser Leu Ser Gln Ala Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Thr Leu Thr Phe Lys His Cys Ala Glu Gln Pro Ser His Ala Arg 
            180                 185                 190         


Thr Tyr Ser Ser Asn Thr Thr Leu Leu Asp Ala Lys Val Trp Arg Pro 
        195                 200                 205             


Leu Gly Arg Pro Gly Ala His Ala Ser Arg Asp Glu Cys Arg Ile His 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Val Gly 
225                 230                 235                 240 


Arg Glu Ala Arg Lys Trp Leu Gln Leu Ala Val Phe Cys Ser Pro Leu 
                245                 250                 255     


Val Pro Gly Gln Ser His Leu Gln Leu Arg Ile Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Leu Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Leu Arg Gly Pro Cys Gln Leu Phe Asp Phe Asn Gly Ala Arg 
    290                 295                 300                 


Gly Asp Gln Cys Leu Lys Leu Thr Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Cys Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asp 
            340                 345                 350         


Glu Asn Glu Asp Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Met Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Ser Trp Ala Ala Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Pro Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Arg Met Leu Leu Glu Pro Asn Ser Ile Thr Gly Asn Asp Trp Arg Arg 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Val Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Ser Gly Thr His Gly 
                485                 490                 495     


Gly Ser Pro Gly Pro Glu Arg Gly Gly Ala Arg Asp Asn Gln Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Leu 
        515             


<210>  37
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Cys Pro Gln Glu Ser Ser Phe Gln Pro Ser Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Val Pro Val Ala Ser Val Leu Leu Leu Ala Gln Cys Leu Arg 
            20                  25                  30          


Trp His Cys Pro Arg Arg Leu Leu Gly Ala Cys Trp Thr Leu Asn Gly 
        35                  40                  45              


Gln Glu Glu Pro Val Ser Gln Pro Thr Pro Gln Leu Glu Asn Glu Val 
    50                  55                  60                  


Ser Arg Gln His Leu Pro Ala Thr Leu Pro Glu Met Val Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Thr Pro Thr Gln Gly Gln Thr Met Val Arg Gln Leu 
                85                  90                  95      


Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Ala Val Gly Arg Gln Glu Arg Val Ser Leu Ile Leu Val 
    130                 135                 140                 


Trp Asp Leu Ser Asp Ala Pro Ser Leu Ser Gln Ala Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Thr Leu Thr Phe Lys His Cys Ala Glu Gln Pro Ser His Ala Arg 
            180                 185                 190         


Thr Tyr Ser Ser Asn Thr Thr Leu Leu Asp Ala Lys Val Trp Arg Pro 
        195                 200                 205             


Leu Gly Arg Pro Gly Ala His Ala Ser Arg Asp Glu Cys Arg Ile His 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Val Gly 
225                 230                 235                 240 


Arg Glu Ala Arg Lys Trp Leu Gln Leu Ala Val Phe Cys Ser Pro Leu 
                245                 250                 255     


Val Pro Gly Gln Ser His Leu Gln Leu Arg Ile Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Leu Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Leu Arg Gly Pro Cys Gln Leu Phe Asp Phe Asn Gly Ala Arg 
    290                 295                 300                 


Gly Asp Gln Cys Leu Lys Leu Thr Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Cys Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asp 
            340                 345                 350         


Glu Asn Glu Asp Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Met Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Ser Trp Ala Ala Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Pro Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Arg Met Leu Leu Glu Pro Asn Ser Ile Thr Gly Asn Asp Trp Arg Arg 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Val Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Ser Gly Thr His Gly 
                485                 490                 495     


Gly Ser Pro Gly Pro Glu Arg Gly Gly Ala Arg Asp Asn Gln Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Leu 
        515             


<210>  38
<211>  518
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ser Pro Gln Glu Ser Ser Val Gln Pro Ser Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Ile Pro Val Ala Ser Ala Leu Leu Leu Ala Gln Cys Leu Arg 
            20                  25                  30          


Trp His Cys Cys Gln Trp Leu Pro Gly Thr Cys Arg Lys Leu Asp Asp 
        35                  40                  45              


Pro Glu Glu Pro Val Ser Pro Ser Thr Pro Leu Pro Glu Tyr Glu Leu 
    50                  55                  60                  


Pro Arg Gln Cys Pro Ala Pro Thr Leu Pro Glu Val Ala Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Met Pro Thr Gln Gly Gln Thr Val Thr Arg Gln Met 
                85                  90                  95      


Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Ile Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Thr Val Gly Arg Gln Glu Arg Val Ser Leu Val Leu Val 
    130                 135                 140                 


Trp Asp Leu Thr Asp Ala Pro Ser Leu Ser His Arg Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Thr Leu Thr Phe Lys His Cys Ala Gln Gln Pro Ser Gln Ala Cys 
            180                 185                 190         


Ala Tyr Ser Ser Asn Thr Ser Leu Leu Asp Ala Lys Asp Trp Lys Pro 
        195                 200                 205             


Leu Gly Gln Pro Gly Thr His Ile Ser Arg Asp Glu Cys Arg Ile Leu 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Leu Gly 
225                 230                 235                 240 


Gln Thr Ala Arg Lys Trp Leu Gln Leu Ala Met Phe Cys Ser Pro Leu 
                245                 250                 255     


Val Pro Gly Gln Thr His Leu Gln Leu Arg Val Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Ile Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Met Arg Gly Pro Cys Gln Leu Phe Asp Phe Thr Gly Ala Arg 
    290                 295                 300                 


Ala Asp Gln Cys Leu Lys Leu Lys Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Ser Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asn 
            340                 345                 350         


Gly Asn Glu Glu Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Val Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Thr Trp Ala Val Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Leu Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Gln Met Leu Leu Glu Pro Asn Ser Val Thr Gly Asn Asp Trp Arg Arg 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Ser Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Asn Arg Ser Pro Arg 
                485                 490                 495     


Gly Ser Pro Asp Arg Leu His Gly Gly Thr Trp Glu Asn His Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Leu 
        515             


<210>  39
<211>  518
<212>  PRT
<213>  Mus musculus

<400>  39

Met Ser Pro Gln Glu Ser Ser Val Gln Pro Ser Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Ile Pro Val Ala Ser Ala Leu Leu Leu Ala Gln Cys Leu Arg 
            20                  25                  30          


Trp His Cys Cys Gln Trp Leu Pro Gly Thr Cys Arg Lys Leu Asp Asp 
        35                  40                  45              


Pro Glu Glu Pro Val Ser Pro Ser Thr Pro Leu Pro Glu Tyr Glu Leu 
    50                  55                  60                  


Pro Arg Gln Cys Pro Ala Pro Thr Leu Pro Glu Val Ala Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Met Pro Thr Gln Gly Gln Thr Val Thr Arg Gln Met 
                85                  90                  95      


Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Ile Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Thr Val Gly Arg Gln Glu Arg Val Ser Leu Val Leu Val 
    130                 135                 140                 


Trp Asp Leu Thr Asp Ala Pro Ser Leu Ser His Arg Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Thr Leu Thr Phe Lys His Cys Ala Gln Gln Pro Ser Gln Ala Cys 
            180                 185                 190         


Ala Tyr Ser Ser Asn Thr Ser Leu Leu Asp Ala Lys Asp Trp Lys Pro 
        195                 200                 205             


Leu Gly Gln Pro Gly Thr His Ile Ser Arg Asp Glu Cys Arg Ile Leu 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Leu Gly 
225                 230                 235                 240 


Gln Thr Ala Arg Lys Trp Leu Gln Leu Ala Met Phe Cys Ser Pro Leu 
                245                 250                 255     


Val Pro Gly Gln Thr His Leu Gln Leu Arg Val Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Ile Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Met Arg Gly Pro Cys Gln Leu Phe Asp Phe Thr Gly Ala Arg 
    290                 295                 300                 


Ala Asp Gln Cys Leu Lys Leu Lys Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Ser Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asn 
            340                 345                 350         


Gly Asn Glu Glu Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Val Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Thr Trp Ala Val Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Leu Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Gln Met Leu Leu Glu Pro Asn Ser Val Thr Gly Asn Asp Trp Arg Arg 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Ser Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Asn Arg Ser Pro Arg 
                485                 490                 495     


Gly Ser Pro Asp Arg Leu His Gly Gly Thr Trp Glu Asn His Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Leu 
        515             


<210>  40
<211>  518
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Met Ser Pro Gln Glu Ser Ser Val Gln Pro Phe Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Ile Pro Val Ala Ser Val Leu Leu Leu Val Gln Cys Leu Arg 
            20                  25                  30          


Trp His Arg Cys Arg Trp Pro Pro Gly Ser Cys Gln Lys Pro Asp Asp 
        35                  40                  45              


Pro Glu Glu Pro Val Ser Pro Ser Thr Pro Leu Pro Glu Tyr Glu Leu 
    50                  55                  60                  


Pro Lys Gln Cys Gln Ala Pro Thr Leu Pro Glu Val Ala Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Met Pro Thr Arg Gly Gln Thr Ile Thr Arg Gln Leu 
                85                  90                  95      


Met Asn Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Thr Val Gly Arg Gln Glu Arg Val Ser Leu Val Leu Val 
    130                 135                 140                 


Trp Asp Leu Thr Asp Ala Pro Ser Leu Ser His Lys Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Ile Leu Thr Phe Lys His Cys Ala Gln Gln Pro Ser Gln Val Cys 
            180                 185                 190         


Ala Tyr Ser Ser Asn Thr Ser Leu Leu Asp Ala Lys Asp Trp Arg Pro 
        195                 200                 205             


Leu Gly Gln Pro Gly Thr His Thr Ser Arg Asp Glu Cys Arg Ile Leu 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Pro Pro Leu Gly 
225                 230                 235                 240 


Gln Thr Ala Arg Lys Trp Leu Gln Leu Ala Met Phe Cys Ser Pro Leu 
                245                 250                 255     


Ala Pro Gly Gln Thr His Leu Gln Leu Arg Val Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Ile Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Met Arg Gly Pro Cys Gln Leu Phe Asp Phe Thr Gly Ala Arg 
    290                 295                 300                 


Ala Asp Gln Cys Leu Lys Leu Lys Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Ser Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ser Ala Asn 
            340                 345                 350         


Gly Asn Glu Glu Cys Ser Thr Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Met Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Thr Trp Ala Val Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Leu Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Gln Met Leu Leu Glu Pro Ser Ser Val Thr Gly Asn Asp Trp Arg Lys 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Ser Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Asn Arg Thr Pro Gly 
                485                 490                 495     


Asp Ser Pro Thr Arg Leu Arg Gly Gly Thr Trp Glu Asn Cys Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Phe 
        515             


<210>  41
<211>  410
<212>  PRT
<213>  Rattus norvegicus

<400>  41

Met Ser Pro Gln Glu Ser Ser Val Gln Pro Phe Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Ile Pro Val Ala Ser Val Leu Leu Leu Val Gln Cys Leu Arg 
            20                  25                  30          


Trp His Arg Cys Arg Trp Pro Pro Gly Ser Cys Gln Lys Pro Asp Asp 
        35                  40                  45              


Pro Glu Glu Pro Val Ser Pro Ser Thr Pro Leu Pro Glu Tyr Glu Leu 
    50                  55                  60                  


Pro Lys Gln Cys Gln Ala Pro Thr Leu Pro Glu Val Ala Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Met Pro Thr Arg Gly Gln Thr Ile Thr Arg Gln Leu 
                85                  90                  95      


Met Asn Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Thr Val Gly Arg Gln Glu Arg Val Ser Leu Val Leu Val 
    130                 135                 140                 


Trp Asp Leu Thr Asp Ala Pro Ser Leu Ser His Lys Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Ile Leu Thr Phe Lys His Cys Ala Gln Gln Pro Ser Gln Val Cys 
            180                 185                 190         


Ala Tyr Ser Ser Asn Thr Ser Leu Leu Asp Ala Lys Asp Trp Arg Pro 
        195                 200                 205             


Leu Gly Gln Pro Gly Thr His Thr Ser Arg Asp Glu Cys Arg Ile Leu 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Pro Pro Leu Gly 
225                 230                 235                 240 


Gln Thr Ala Arg Lys Trp Leu Gln Leu Ala Met Phe Cys Ser Pro Leu 
                245                 250                 255     


Ala Pro Gly Gln Thr His Leu Gln Leu Arg Val Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Ile Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Met Arg Gly Pro Cys Gln Leu Phe Asp Phe Thr Gly Ala Arg 
    290                 295                 300                 


Ala Asp Gln Cys Leu Lys Leu Lys Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Ser Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ser Gly Cys 
            340                 345                 350         


Pro Gln Ser Ser Leu Ser Ser Cys Arg Cys Cys Trp Ser Pro Ala Val 
        355                 360                 365             


Ser Leu Gly Met Thr Gly Ala Asn Trp Leu Ala Leu Ser Gln Ser Gln 
    370                 375                 380                 


Pro Leu Arg Tyr Leu Cys Leu His Val Ala Leu Ser Pro Ser Ser Tyr 
385                 390                 395                 400 


Gly Ile Pro Ser Leu Cys Phe Phe Leu Tyr 
                405                 410 


<210>  42
<211>  265
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  42

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe Pro Gly Ile Trp Ala Pro Pro Thr Asp Val 
145                 150                 155                 160 


Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala 
                165                 170                 175     


His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly 
            180                 185                 190         


Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly 
        195                 200                 205             


Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala 
    210                 215                 220                 


Leu Gly Ile Asp Glu Tyr Gly Gly Leu Glu Arg Leu Glu Gln Leu Phe 
225                 230                 235                 240 


Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp 
                245                 250                 255     


Ser Leu Gln Asp Ile Lys Ala Leu Leu 
            260                 265 


<210>  43
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  43

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210>  44
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic polynucleotide sequence

<400>  44
cggagtactg tcctccgag                                                    19


<210>  45
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic polynucleotide sequence

<400>  45
ggagcactgt cctccgaacg tc                                                22


<210>  46
<211>  1817
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Thr Ser Gly 
                405                 410                 415     


Asn Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser 
                645                 650                 655     


His Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val 
785                 790                 795                 800 


Val Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Ser Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Ser Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp 
945                 950                 955                 960 


Thr Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Thr  Asp Glu Glu Asp Val  Asp Met Ala 
        995                 1000                 1005             


Leu Asp  Gln Arg Phe Ser Arg  Leu Pro Ser Lys Ala  Asp Thr Ser 
    1010                 1015                 1020             


Gln Glu  Ile Cys Ser Pro Arg  Leu Pro Ile Ser Ala  Ser His Ser 
    1025                 1030                 1035             


Ser Lys  Thr Arg Ser Leu Val  Gly Gly Leu Leu Gln  Ser Lys Phe 
    1040                 1045                 1050             


Thr Ser  Gly Ala Phe Leu Ser  Pro Ser Val Ser Val  Gln Glu Cys 
    1055                 1060                 1065             


Arg Thr  Pro Arg Ala Ala Ser  Leu Met Asn Ile Pro  Ser Thr Ser 
    1070                 1075                 1080             


Ser Trp  Ser Val Pro Pro Pro  Leu Thr Ser Val Phe  Thr Met Pro 
    1085                 1090                 1095             


Ser Pro  Ala Pro Glu Val Pro  Leu Lys Thr Val Gly  Thr Arg Arg 
    1100                 1105                 1110             


Gln Leu  Gly Leu Val Pro Arg  Glu Lys Ser Val Thr  Tyr Gly Lys 
    1115                 1120                 1125             


Gly Lys  Leu Leu Met Asp Met  Ala Leu Phe Met Gly  Arg Ser Phe 
    1130                 1135                 1140             


Arg Val  Gly Trp Gly Pro Asn  Trp Thr Leu Ala Asn  Ser Gly Glu 
    1145                 1150                 1155             


Gln Leu  Asn Gly Ser His Glu  Leu Glu Asn His Gln  Ile Ala Asp 
    1160                 1165                 1170             


Ser Met  Glu Phe Gly Phe Leu  Pro Asn Pro Val Ala  Val Lys Pro 
    1175                 1180                 1185             


Leu Thr  Glu Ser Pro Phe Lys  Val His Leu Glu Lys  Leu Ser Leu 
    1190                 1195                 1200             


Arg Gln  Arg Lys Pro Asp Glu  Asp Met Lys Leu Tyr  Gln Thr Pro 
    1205                 1210                 1215             


Leu Glu  Leu Lys Leu Lys His  Ser Thr Val His Val  Asp Glu Leu 
    1220                 1225                 1230             


Cys Pro  Leu Ile Val Pro Asn  Leu Gly Val Ala Val  Ile His Asp 
    1235                 1240                 1245             


Tyr Ala  Asp Trp Val Lys Glu  Ala Ser Gly Asp Leu  Pro Glu Ala 
    1250                 1255                 1260             


Gln Ile  Val Lys His Trp Ser  Leu Thr Trp Thr Leu  Cys Glu Ala 
    1265                 1270                 1275             


Leu Trp  Gly His Leu Lys Glu  Leu Asp Ser Gln Leu  Asn Glu Pro 
    1280                 1285                 1290             


Arg Glu  Tyr Ile Gln Ile Leu  Glu Arg Arg Arg Ala  Phe Ser Arg 
    1295                 1300                 1305             


Trp Leu  Ser Cys Thr Ala Thr  Pro Gln Ile Glu Glu  Glu Val Ser 
    1310                 1315                 1320             


Leu Thr  Gln Lys Asn Ser Pro  Val Glu Ala Val Phe  Ser Tyr Leu 
    1325                 1330                 1335             


Thr Gly  Lys Arg Ile Ser Glu  Ala Cys Ser Leu Ala  Gln Gln Ser 
    1340                 1345                 1350             


Gly Asp  His Arg Leu Ala Leu  Leu Leu Ser Gln Phe  Val Gly Ser 
    1355                 1360                 1365             


Gln Ser  Val Arg Glu Leu Leu  Thr Met Gln Leu Val  Asp Trp His 
    1370                 1375                 1380             


Gln Leu  Gln Ala Asp Ser Phe  Ile Gln Asp Glu Arg  Leu Arg Ile 
    1385                 1390                 1395             


Phe Ala  Leu Leu Ala Gly Lys  Pro Val Trp Gln Leu  Ser Glu Lys 
    1400                 1405                 1410             


Lys Gln  Ile Asn Val Cys Ser  Gln Leu Asp Trp Lys  Arg Ser Leu 
    1415                 1420                 1425             


Ala Ile  His Leu Trp Tyr Leu  Leu Pro Pro Thr Ala  Ser Ile Ser 
    1430                 1435                 1440             


Arg Ala  Leu Ser Met Tyr Glu  Glu Ala Phe Gln Asn  Thr Ser Asp 
    1445                 1450                 1455             


Ser Asp  Arg Tyr Ala Cys Ser  Pro Leu Pro Ser Tyr  Leu Glu Gly 
    1460                 1465                 1470             


Ser Gly  Cys Val Ile Ala Glu  Glu Gln Asn Ser Gln  Thr Pro Leu 
    1475                 1480                 1485             


Arg Asp  Val Cys Phe His Leu  Leu Lys Leu Tyr Ser  Asp Arg His 
    1490                 1495                 1500             


Tyr Asp  Leu Asn Gln Leu Leu  Glu Pro Arg Ser Ile  Thr Ala Asp 
    1505                 1510                 1515             


Pro Leu  Asp Tyr Arg Leu Ser  Trp His Leu Trp Glu  Val Leu Arg 
    1520                 1525                 1530             


Ala Leu  Asn Tyr Thr His Leu  Ser Ala Gln Cys Glu  Gly Val Leu 
    1535                 1540                 1545             


Gln Ala  Ser Tyr Ala Gly Gln  Leu Glu Ser Glu Gly  Leu Trp Glu 
    1550                 1555                 1560             


Trp Ala  Ile Phe Val Leu Leu  His Ile Asp Asn Ser  Gly Ile Arg 
    1565                 1570                 1575             


Glu Lys  Ala Val Arg Glu Leu  Leu Thr Arg His Cys  Gln Leu Leu 
    1580                 1585                 1590             


Glu Thr  Pro Glu Ser Trp Ala  Lys Glu Thr Phe Leu  Thr Gln Lys 
    1595                 1600                 1605             


Leu Arg  Val Pro Ala Lys Trp  Ile His Glu Ala Lys  Ala Val Arg 
    1610                 1615                 1620             


Ala His  Met Glu Ser Asp Lys  His Leu Glu Ala Leu  Cys Leu Phe 
    1625                 1630                 1635             


Lys Ala  Glu His Trp Asn Arg  Cys His Lys Leu Ile  Ile Arg His 
    1640                 1645                 1650             


Leu Ala  Ser Asp Ala Ile Ile  Asn Glu Asn Tyr Asp  Tyr Leu Lys 
    1655                 1660                 1665             


Gly Phe  Leu Glu Asp Leu Ala  Pro Pro Glu Arg Ser  Ser Leu Ile 
    1670                 1675                 1680             


Gln Asp  Trp Glu Thr Ser Gly  Leu Val Tyr Leu Asp  Tyr Ile Arg 
    1685                 1690                 1695             


Val Ile  Glu Met Leu Arg His  Ile Gln Gln Val Asp  Cys Ser Gly 
    1700                 1705                 1710             


Asn Asp  Leu Glu Gln Leu His  Ile Lys Val Thr Ser  Leu Cys Ser 
    1715                 1720                 1725             


Arg Ile  Glu Gln Ile Gln Cys  Tyr Ser Ala Lys Asp  Arg Leu Ala 
    1730                 1735                 1740             


Gln Ser  Asp Met Ala Lys Arg  Val Ala Asn Leu Leu  Arg Val Val 
    1745                 1750                 1755             


Leu Ser  Leu His His Pro Pro  Asp Arg Thr Ser Asp  Ser Thr Pro 
    1760                 1765                 1770             


Asp Pro  Gln Arg Val Pro Leu  Arg Leu Leu Ala Pro  His Ile Gly 
    1775                 1780                 1785             


Arg Leu  Pro Met Pro Glu Asp  Tyr Ala Met Asp Glu  Leu Arg Ser 
    1790                 1795                 1800             


Leu Thr  Gln Ser Tyr Leu Arg  Glu Leu Ala Val Gly  Ser Leu 
    1805                 1810                 1815         


<210>  47
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Thr Ser Gly 
                405                 410                 415     


Asn Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser 
                645                 650                 655     


His Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val 
785                 790                 795                 800 


Val Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Ser Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Ser Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Val Glu Lys Lys Gly Gln 
    930                 935         


<210>  48
<211>  1800
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu 
        915                 920                 925             


Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr 
    930                 935                 940                 


Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser 
945                 950                 955                 960 


Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile 
                965                 970                 975     


Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu 
            980                 985                 990         


Asp Gln Arg Phe Ser Arg Leu Pro  Ser Lys Ala Asp Thr  Ser Gln Glu 
        995                 1000                 1005             


Ile Cys  Ser Pro Arg Leu Pro  Ile Ser Ala Ser His  Ser Ser Lys 
    1010                 1015                 1020             


Thr Arg  Ser Leu Val Gly Gly  Leu Leu Gln Ser Lys  Phe Thr Ser 
    1025                 1030                 1035             


Gly Ala  Phe Leu Ser Pro Ser  Val Ser Val Gln Glu  Cys Arg Thr 
    1040                 1045                 1050             


Pro Arg  Ala Ala Ser Leu Met  Asn Ile Pro Ser Thr  Ser Ser Trp 
    1055                 1060                 1065             


Ser Val  Pro Pro Pro Leu Thr  Ser Val Phe Thr Met  Pro Ser Pro 
    1070                 1075                 1080             


Ala Pro  Glu Val Pro Leu Lys  Thr Val Gly Thr Arg  Arg Gln Leu 
    1085                 1090                 1095             


Gly Leu  Val Pro Arg Glu Lys  Ser Val Thr Tyr Gly  Lys Gly Lys 
    1100                 1105                 1110             


Leu Leu  Met Asp Met Ala Leu  Phe Met Gly Arg Ser  Phe Arg Val 
    1115                 1120                 1125             


Gly Trp  Gly Pro Asn Trp Thr  Leu Ala Asn Ser Gly  Glu Gln Leu 
    1130                 1135                 1140             


Asn Gly  Ser His Glu Leu Glu  Asn His Gln Ile Ala  Asp Ser Met 
    1145                 1150                 1155             


Glu Phe  Gly Phe Leu Pro Asn  Pro Val Ala Val Lys  Pro Leu Thr 
    1160                 1165                 1170             


Glu Ser  Pro Phe Lys Val His  Leu Glu Lys Leu Ser  Leu Arg Gln 
    1175                 1180                 1185             


Arg Lys  Pro Asp Glu Asp Met  Lys Leu Tyr Gln Thr  Pro Leu Glu 
    1190                 1195                 1200             


Leu Lys  Leu Lys His Ser Thr  Val His Val Asp Glu  Leu Cys Pro 
    1205                 1210                 1215             


Leu Ile  Val Pro Asn Leu Gly  Val Ala Val Ile His  Asp Tyr Ala 
    1220                 1225                 1230             


Asp Trp  Val Lys Glu Ala Ser  Gly Asp Leu Pro Glu  Ala Gln Ile 
    1235                 1240                 1245             


Val Lys  His Trp Ser Leu Thr  Trp Thr Leu Cys Glu  Ala Leu Trp 
    1250                 1255                 1260             


Gly His  Leu Lys Glu Leu Asp  Ser Gln Leu Asn Glu  Pro Arg Glu 
    1265                 1270                 1275             


Tyr Ile  Gln Ile Leu Glu Arg  Arg Arg Ala Phe Ser  Arg Trp Leu 
    1280                 1285                 1290             


Ser Cys  Thr Ala Thr Pro Gln  Ile Glu Glu Glu Val  Ser Leu Thr 
    1295                 1300                 1305             


Gln Lys  Asn Ser Pro Val Glu  Ala Val Phe Ser Tyr  Leu Thr Gly 
    1310                 1315                 1320             


Lys Arg  Ile Ser Glu Ala Cys  Ser Leu Ala Gln Gln  Ser Gly Asp 
    1325                 1330                 1335             


His Arg  Leu Ala Leu Leu Leu  Ser Gln Phe Val Gly  Ser Gln Ser 
    1340                 1345                 1350             


Val Arg  Glu Leu Leu Thr Met  Gln Leu Val Asp Trp  His Gln Leu 
    1355                 1360                 1365             


Gln Ala  Asp Ser Phe Ile Gln  Asp Glu Arg Leu Arg  Ile Phe Ala 
    1370                 1375                 1380             


Leu Leu  Ala Gly Lys Pro Val  Trp Gln Leu Ser Glu  Lys Lys Gln 
    1385                 1390                 1395             


Ile Asn  Val Cys Ser Gln Leu  Asp Trp Lys Arg Ser  Leu Ala Ile 
    1400                 1405                 1410             


His Leu  Trp Tyr Leu Leu Pro  Pro Thr Ala Ser Ile  Ser Arg Ala 
    1415                 1420                 1425             


Leu Ser  Met Tyr Glu Glu Ala  Phe Gln Asn Thr Ser  Asp Ser Asp 
    1430                 1435                 1440             


Arg Tyr  Ala Cys Ser Pro Leu  Pro Ser Tyr Leu Glu  Gly Ser Gly 
    1445                 1450                 1455             


Cys Val  Ile Ala Glu Glu Gln  Asn Ser Gln Thr Pro  Leu Arg Asp 
    1460                 1465                 1470             


Val Cys  Phe His Leu Leu Lys  Leu Tyr Ser Asp Arg  His Tyr Asp 
    1475                 1480                 1485             


Leu Asn  Gln Leu Leu Glu Pro  Arg Ser Ile Thr Ala  Asp Pro Leu 
    1490                 1495                 1500             


Asp Tyr  Arg Leu Ser Trp His  Leu Trp Glu Val Leu  Arg Ala Leu 
    1505                 1510                 1515             


Asn Tyr  Thr His Leu Ser Ala  Gln Cys Glu Gly Val  Leu Gln Ala 
    1520                 1525                 1530             


Ser Tyr  Ala Gly Gln Leu Glu  Ser Glu Gly Leu Trp  Glu Trp Ala 
    1535                 1540                 1545             


Ile Phe  Val Leu Leu His Ile  Asp Asn Ser Gly Ile  Arg Glu Lys 
    1550                 1555                 1560             


Ala Val  Arg Glu Leu Leu Thr  Arg His Cys Gln Leu  Leu Glu Thr 
    1565                 1570                 1575             


Pro Glu  Ser Trp Ala Lys Glu  Thr Phe Leu Thr Gln  Lys Leu Arg 
    1580                 1585                 1590             


Val Pro  Ala Lys Trp Ile His  Glu Ala Lys Ala Val  Arg Ala His 
    1595                 1600                 1605             


Met Glu  Ser Asp Lys His Leu  Glu Ala Leu Cys Leu  Phe Lys Ala 
    1610                 1615                 1620             


Glu His  Trp Asn Arg Cys His  Lys Leu Ile Ile Arg  His Leu Ala 
    1625                 1630                 1635             


Ser Asp  Ala Ile Ile Asn Glu  Asn Tyr Asp Tyr Leu  Lys Gly Phe 
    1640                 1645                 1650             


Leu Glu  Asp Leu Ala Pro Pro  Glu Arg Ser Ser Leu  Ile Gln Asp 
    1655                 1660                 1665             


Trp Glu  Thr Ser Gly Leu Val  Tyr Leu Asp Tyr Ile  Arg Val Ile 
    1670                 1675                 1680             


Glu Met  Leu Arg His Ile Gln  Gln Val Asp Cys Ser  Gly Asn Asp 
    1685                 1690                 1695             


Leu Glu  Gln Leu His Ile Lys  Val Thr Ser Leu Cys  Ser Arg Ile 
    1700                 1705                 1710             


Glu Gln  Ile Gln Cys Tyr Ser  Ala Lys Asp Arg Leu  Ala Gln Ser 
    1715                 1720                 1725             


Asp Met  Ala Lys Arg Val Ala  Asn Leu Leu Arg Val  Val Leu Ser 
    1730                 1735                 1740             


Leu His  His Pro Pro Asp Arg  Thr Ser Asp Ser Thr  Pro Asp Pro 
    1745                 1750                 1755             


Gln Arg  Val Pro Leu Arg Leu  Leu Ala Pro His Ile  Gly Arg Leu 
    1760                 1765                 1770             


Pro Met  Pro Glu Asp Tyr Ala  Met Asp Glu Leu Arg  Ser Leu Thr 
    1775                 1780                 1785             


Gln Ser  Tyr Leu Arg Glu Leu  Ala Val Gly Ser Leu  
    1790                 1795                 1800 


<210>  49
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Val Glu Lys Lys Gly Gln 
        915                 920 


<210>  50
<211>  1726
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu 
        915                 920                 925             


Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr 
    930                 935                 940                 


Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser 
945                 950                 955                 960 


Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile 
                965                 970                 975     


Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu 
            980                 985                 990         


Asp Gln Arg Phe Ser Arg Leu Pro  Ser Lys Ala Asp Thr  Ser Gln Glu 
        995                 1000                 1005             


Ile Cys  Ser Pro Arg Leu Pro  Ile Ser Ala Ser His  Ser Ser Lys 
    1010                 1015                 1020             


Thr Arg  Ser Leu Val Gly Gly  Leu Leu Gln Ser Lys  Phe Thr Ser 
    1025                 1030                 1035             


Gly Ala  Phe Leu Ser Pro Ser  Val Ser Val Gln Glu  Cys Arg Thr 
    1040                 1045                 1050             


Pro Arg  Ala Ala Ser Leu Met  Asn Ile Pro Ser Thr  Ser Ser Trp 
    1055                 1060                 1065             


Ser Val  Pro Pro Pro Leu Thr  Ser Val Phe Thr Met  Pro Ser Pro 
    1070                 1075                 1080             


Ala Pro  Glu Val Pro Leu Lys  Thr Val Gly Thr Arg  Arg Gln Leu 
    1085                 1090                 1095             


Gly Leu  Val Pro Arg Glu Lys  Ser Val Thr Tyr Gly  Lys Gly Lys 
    1100                 1105                 1110             


Leu Leu  Met Asp Met Ala Leu  Phe Met Gly Arg Ser  Phe Arg Val 
    1115                 1120                 1125             


Gly Trp  Gly Pro Asn Trp Thr  Leu Ala Asn Ser Gly  Glu Gln Leu 
    1130                 1135                 1140             


Asn Gly  Ser His Glu Leu Glu  Asn His Gln Ile Ala  Asp Ser Met 
    1145                 1150                 1155             


Glu Phe  Gly Phe Leu Pro Asn  Pro Val Ala Val Lys  Pro Leu Thr 
    1160                 1165                 1170             


Glu Ser  Pro Phe Lys Val His  Leu Glu Lys Leu Ser  Leu Arg Gln 
    1175                 1180                 1185             


Arg Lys  Pro Asp Glu Asp Met  Lys Leu Tyr Gln Thr  Pro Leu Glu 
    1190                 1195                 1200             


Leu Lys  Leu Lys His Ser Thr  Val His Val Asp Glu  Leu Cys Pro 
    1205                 1210                 1215             


Leu Ile  Val Pro Asn Leu Gly  Val Ala Val Ile His  Asp Tyr Ala 
    1220                 1225                 1230             


Asp Trp  Val Lys Glu Ala Ser  Gly Asp Leu Pro Glu  Ala Gln Ile 
    1235                 1240                 1245             


Val Lys  His Trp Ser Leu Thr  Trp Thr Leu Cys Glu  Ala Leu Trp 
    1250                 1255                 1260             


Gly His  Leu Lys Glu Leu Asp  Ser Gln Leu Asn Glu  Pro Arg Glu 
    1265                 1270                 1275             


Tyr Ile  Gln Ile Leu Glu Arg  Arg Arg Ala Phe Ser  Arg Trp Leu 
    1280                 1285                 1290             


Ser Cys  Thr Ala Thr Pro Gln  Ile Glu Glu Glu Val  Ser Leu Thr 
    1295                 1300                 1305             


Gln Lys  Asn Ser Pro Val Glu  Ala Val Phe Ser Tyr  Leu Thr Gly 
    1310                 1315                 1320             


Lys Arg  Ile Ser Glu Ala Cys  Ser Leu Ala Gln Gln  Ser Gly Asp 
    1325                 1330                 1335             


His Arg  Leu Ala Leu Leu Leu  Ser Gln Phe Val Gly  Ser Gln Ser 
    1340                 1345                 1350             


Val Arg  Glu Leu Leu Thr Met  Gln Leu Val Asp Trp  His Gln Leu 
    1355                 1360                 1365             


Gln Ala  Asp Ser Phe Ile Gln  Asp Glu Arg Leu Arg  Ile Phe Ala 
    1370                 1375                 1380             


Leu Leu  Ala Gly Lys Pro Val  Trp Gln Leu Ser Glu  Lys Lys Gln 
    1385                 1390                 1395             


Ile Asn  Val Cys Ser Gln Leu  Asp Trp Lys Arg Ser  Leu Ala Ile 
    1400                 1405                 1410             


His Leu  Trp Tyr Leu Leu Pro  Pro Thr Ala Ser Ile  Ser Arg Ala 
    1415                 1420                 1425             


Leu Ser  Met Tyr Glu Glu Ala  Phe Gln Asn Thr Ser  Asp Ser Asp 
    1430                 1435                 1440             


Arg Tyr  Ala Cys Ser Pro Leu  Pro Ser Tyr Leu Glu  Gly Ser Gly 
    1445                 1450                 1455             


Cys Val  Ile Ala Glu Glu Gln  Asn Ser Gln Thr Pro  Leu Arg Asp 
    1460                 1465                 1470             


Val Cys  Phe His Leu Leu Lys  Leu Tyr Ser Asp Ser  Ile Arg Glu 
    1475                 1480                 1485             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Leu Glu 
    1490                 1495                 1500             


Thr Pro  Glu Ser Trp Ala Lys  Glu Thr Phe Leu Thr  Gln Lys Leu 
    1505                 1510                 1515             


Arg Val  Pro Ala Lys Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1520                 1525                 1530             


His Met  Glu Ser Asp Lys His  Leu Glu Ala Leu Cys  Leu Phe Lys 
    1535                 1540                 1545             


Ala Glu  His Trp Asn Arg Cys  His Lys Leu Ile Ile  Arg His Leu 
    1550                 1555                 1560             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1565                 1570                 1575             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1580                 1585                 1590             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1595                 1600                 1605             


Ile Glu  Met Leu Arg His Ile  Gln Gln Val Asp Cys  Ser Gly Asn 
    1610                 1615                 1620             


Asp Leu  Glu Gln Leu His Ile  Lys Val Thr Ser Leu  Cys Ser Arg 
    1625                 1630                 1635             


Ile Glu  Gln Ile Gln Cys Tyr  Ser Ala Lys Asp Arg  Leu Ala Gln 
    1640                 1645                 1650             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1655                 1660                 1665             


Ser Leu  His His Pro Pro Asp  Arg Thr Ser Asp Ser  Thr Pro Asp 
    1670                 1675                 1680             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1685                 1690                 1695             


Leu Pro  Met Pro Glu Asp Tyr  Ala Met Asp Glu Leu  Arg Ser Leu 
    1700                 1705                 1710             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Ala Val Gly Ser  Leu 
    1715                 1720                 1725     


<210>  51
<211>  1816
<212>  PRT
<213>  Mus musculus

<400>  51

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Ser Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Gly Gly Thr Thr 
    210                 215                 220                 


Ala Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Asn Ser Gly 
                405                 410                 415     


Ser Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn Asn Gln Gln Asp Gly Glu Asp Asp Ser Leu Val Ser 
                645                 650                 655     


Arg Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Val Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ala Tyr His Ile His Pro Ala Gly Ile Val Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile 
785                 790                 795                 800 


Val Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Pro Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Gly Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp 
945                 950                 955                 960 


Ser Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Val  Asp Glu Glu Asp Val  Asp Ala Met 
        995                 1000                 1005             


Asp Gln  Arg Phe Gly His Ile  Pro Ser Lys Gly Glu  Thr Val Gln 
    1010                 1015                 1020             


Glu Ile  Cys Ser Pro Arg Leu  Pro Ile Ser Ala Ser  His Ser Ser 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Val Gly  Gly Leu Leu Gln Ser  Lys Phe Ala 
    1040                 1045                 1050             


Ser Gly  Thr Phe Leu Ser Pro  Ser Ala Ser Val Gln  Glu Cys Arg 
    1055                 1060                 1065             


Thr Pro  Arg Thr Ser Ser Arg  Met Asn Ile Pro Ser  Thr Ser Pro 
    1070                 1075                 1080             


Trp Ser  Val Pro Leu Pro Leu  Ala Thr Val Phe Thr  Val Pro Ser 
    1085                 1090                 1095             


Pro Ala  Pro Glu Val Gln Leu  Lys Thr Val Gly Ile  Arg Arg Gln 
    1100                 1105                 1110             


Pro Gly  Leu Val Pro Leu Glu  Lys Ser Ile Thr Tyr  Gly Lys Gly 
    1115                 1120                 1125             


Lys Leu  Leu Met Asp Met Ala  Leu Phe Met Gly Arg  Ser Phe Arg 
    1130                 1135                 1140             


Val Gly  Trp Gly Pro Asn Trp  Thr Leu Ala Asn Ser  Gly Glu Gln 
    1145                 1150                 1155             


Leu His  Gly Ser His Glu Leu  Glu Asn His Gln Val  Ala Asp Ser 
    1160                 1165                 1170             


Met Glu  Tyr Gly Phe Leu Pro  Asn Pro Val Ala Val  Lys Ser Leu 
    1175                 1180                 1185             


Ser Glu  Ser Pro Phe Lys Val  His Leu Glu Lys Leu  Gly Leu Arg 
    1190                 1195                 1200             


Gln Arg  Lys Leu Asp Glu Asp  Leu Gln Leu Tyr Gln  Thr Pro Leu 
    1205                 1210                 1215             


Glu Leu  Lys Leu Lys His Ser  Thr Val His Val Asp  Glu Leu Cys 
    1220                 1225                 1230             


Pro Leu  Ile Val Pro Asn Pro  Gly Val Ser Val Ile  His Asp Tyr 
    1235                 1240                 1245             


Ala Asp  Trp Val Lys Asp Ser  Pro Gly Asp Phe Leu  Glu Leu Pro 
    1250                 1255                 1260             


Ile Val  Lys His Trp Ser Leu  Thr Trp Thr Leu Cys  Glu Ala Leu 
    1265                 1270                 1275             


Trp Gly  His Leu Lys Glu Leu  Asp Gly Gln Leu Asp  Glu Pro Ser 
    1280                 1285                 1290             


Glu Tyr  Ile Gln Thr Leu Glu  Arg Arg Arg Ala Phe  Ser Arg Trp 
    1295                 1300                 1305             


Leu Ser  His Thr Ala Ala Pro  Gln Ile Glu Glu Glu  Val Ser Leu 
    1310                 1315                 1320             


Thr Arg  Arg Asp Ser Pro Val  Glu Ala Val Phe Ser  Tyr Leu Thr 
    1325                 1330                 1335             


Gly Ser  Arg Ile Ser Gly Ala  Cys Cys Leu Ala Gln  Gln Ser Gly 
    1340                 1345                 1350             


Asp His  Arg Leu Ala Leu Leu  Leu Ser Gln Leu Val  Gly Ser Gln 
    1355                 1360                 1365             


Ser Val  Arg Glu Leu Leu Thr  Met Gln Leu Ala Asp  Trp His Gln 
    1370                 1375                 1380             


Leu Gln  Ala Asp Ser Phe Ile  His Asp Glu Arg Leu  Arg Ile Phe 
    1385                 1390                 1395             


Ala Leu  Leu Ala Gly Lys Pro  Val Trp Gln Leu Ser  Glu Gln Lys 
    1400                 1405                 1410             


Gln Ile  Asn Val Cys Ser Gln  Leu Asp Trp Lys Arg  Thr Leu Ala 
    1415                 1420                 1425             


Ile His  Leu Trp Tyr Leu Leu  Pro Pro Thr Ala Ser  Ile Ser Arg 
    1430                 1435                 1440             


Ala Leu  Ser Met Tyr Glu Glu  Ala Phe Gln Asn Thr  Pro Glu Gly 
    1445                 1450                 1455             


Asp Lys  Tyr Ala Cys Ser Pro  Leu Pro Ser Tyr Leu  Glu Gly Cys 
    1460                 1465                 1470             


Gly Cys  Met Val Glu Glu Glu  Lys Asp Ser Arg Arg  Pro Leu Gln 
    1475                 1480                 1485             


Asp Val  Cys Phe His Leu Leu  Lys Leu Tyr Ser Asp  Arg His Tyr 
    1490                 1495                 1500             


Glu Leu  Asn Gln Leu Leu Glu  Pro Arg Ser Ile Thr  Ala Asp Pro 
    1505                 1510                 1515             


Leu Asp  Tyr Arg Leu Ser Trp  His Leu Trp Glu Val  Leu Arg Ala 
    1520                 1525                 1530             


Leu Asn  Tyr Thr His Leu Ser  Glu Gln Cys Glu Gly  Val Leu Gln 
    1535                 1540                 1545             


Ala Ser  Tyr Ala Gly Gln Leu  Glu Ser Glu Gly Leu  Trp Glu Trp 
    1550                 1555                 1560             


Ala Ile  Phe Val Phe Leu His  Ile Asp Asn Ser Gly  Met Arg Glu 
    1565                 1570                 1575             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Ser Glu 
    1580                 1585                 1590             


Thr Pro  Glu Ser Trp Ala Lys  Glu Ala Phe Leu Thr  Gln Lys Leu 
    1595                 1600                 1605             


Cys Val  Pro Ala Glu Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1610                 1615                 1620             


His Met  Glu Ser Asn Lys His  Leu Glu Ala Leu Tyr  Leu Phe Lys 
    1625                 1630                 1635             


Ala Gly  His Trp Asn Arg Cys  His Lys Leu Val Ile  Arg His Leu 
    1640                 1645                 1650             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1655                 1660                 1665             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1670                 1675                 1680             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1685                 1690                 1695             


Ile Glu  Met Leu His Arg Ile  Gln Gln Val Asp Cys  Ser Gly Tyr 
    1700                 1705                 1710             


Glu Leu  Glu His Leu His Thr  Lys Val Thr Ser Leu  Cys Asn Arg 
    1715                 1720                 1725             


Ile Glu  Gln Ile Pro Cys Tyr  Asn Ala Lys Asp Arg  Leu Ala Gln 
    1730                 1735                 1740             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1745                 1750                 1755             


Ser Leu  Gln His Ala Pro Asp  Ala Thr Ser Asn Ser  Thr Pro Asp 
    1760                 1765                 1770             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1775                 1780                 1785             


Leu Pro  Met Pro Glu Asp Tyr  Ala Leu Glu Glu Leu  Arg Gly Leu 
    1790                 1795                 1800             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Thr Val Gly Ser  Gln 
    1805                 1810                 1815     


<210>  52
<211>  1816
<212>  PRT
<213>  Mus musculus

<400>  52

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Ser Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Gly Gly Thr Thr 
    210                 215                 220                 


Ala Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Asn Ser Gly 
                405                 410                 415     


Ser Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn Asn Gln Gln Asp Gly Glu Asp Asp Ser Leu Val Ser 
                645                 650                 655     


Arg Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Val Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ala Tyr His Ile His Pro Ala Gly Ile Val Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile 
785                 790                 795                 800 


Val Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Pro Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Gly Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp 
945                 950                 955                 960 


Ser Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Val  Asp Glu Glu Asp Val  Asp Ala Met 
        995                 1000                 1005             


Asp Gln  Arg Phe Gly His Ile  Pro Ser Lys Gly Glu  Thr Val Gln 
    1010                 1015                 1020             


Glu Ile  Cys Ser Pro Arg Leu  Pro Ile Ser Ala Ser  His Ser Ser 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Val Gly  Gly Leu Leu Gln Ser  Lys Phe Ala 
    1040                 1045                 1050             


Ser Gly  Thr Phe Leu Ser Pro  Ser Ala Ser Val Gln  Glu Cys Arg 
    1055                 1060                 1065             


Thr Pro  Arg Thr Ser Ser Arg  Met Asn Ile Pro Ser  Thr Ser Pro 
    1070                 1075                 1080             


Trp Ser  Val Pro Leu Pro Leu  Ala Thr Val Phe Thr  Val Pro Ser 
    1085                 1090                 1095             


Pro Ala  Pro Glu Val Gln Leu  Lys Thr Val Gly Ile  Arg Arg Gln 
    1100                 1105                 1110             


Pro Gly  Leu Val Pro Leu Glu  Lys Ser Ile Thr Tyr  Gly Lys Gly 
    1115                 1120                 1125             


Lys Leu  Leu Met Asp Met Ala  Leu Phe Met Gly Arg  Ser Phe Arg 
    1130                 1135                 1140             


Val Gly  Trp Gly Pro Asn Trp  Thr Leu Ala Asn Ser  Gly Glu Gln 
    1145                 1150                 1155             


Leu His  Gly Ser His Glu Leu  Glu Asn His Gln Val  Ala Asp Ser 
    1160                 1165                 1170             


Met Glu  Tyr Gly Phe Leu Pro  Asn Pro Val Ala Val  Lys Ser Leu 
    1175                 1180                 1185             


Ser Glu  Ser Pro Phe Lys Val  His Leu Glu Lys Leu  Gly Leu Arg 
    1190                 1195                 1200             


Gln Arg  Lys Leu Asp Glu Asp  Leu Gln Leu Tyr Gln  Thr Pro Leu 
    1205                 1210                 1215             


Glu Leu  Lys Leu Lys His Ser  Thr Val His Val Asp  Glu Leu Cys 
    1220                 1225                 1230             


Pro Leu  Ile Val Pro Asn Pro  Gly Val Ser Val Ile  His Asp Tyr 
    1235                 1240                 1245             


Ala Asp  Trp Val Lys Asp Ser  Pro Gly Asp Phe Leu  Glu Leu Pro 
    1250                 1255                 1260             


Ile Val  Lys His Trp Ser Leu  Thr Trp Thr Leu Cys  Glu Ala Leu 
    1265                 1270                 1275             


Trp Gly  His Leu Lys Glu Leu  Asp Gly Gln Leu Asp  Glu Pro Ser 
    1280                 1285                 1290             


Glu Tyr  Ile Gln Thr Leu Glu  Arg Arg Arg Ala Phe  Ser Arg Trp 
    1295                 1300                 1305             


Leu Ser  His Thr Ala Ala Pro  Gln Ile Glu Glu Glu  Val Ser Leu 
    1310                 1315                 1320             


Thr Arg  Arg Asp Ser Pro Val  Glu Ala Val Phe Ser  Tyr Leu Thr 
    1325                 1330                 1335             


Gly Ser  Arg Ile Ser Glu Ala  Cys Cys Leu Ala Gln  Gln Ser Gly 
    1340                 1345                 1350             


Asp His  Arg Leu Ala Leu Leu  Leu Ser Gln Leu Val  Gly Ser Gln 
    1355                 1360                 1365             


Ser Val  Arg Glu Leu Leu Thr  Met Gln Leu Ala Asp  Trp His Gln 
    1370                 1375                 1380             


Leu Gln  Ala Asp Ser Phe Ile  His Asp Glu Arg Leu  Arg Ile Phe 
    1385                 1390                 1395             


Ala Leu  Leu Ala Gly Lys Pro  Val Trp Gln Leu Ser  Glu Gln Lys 
    1400                 1405                 1410             


Gln Ile  Asn Val Cys Ser Gln  Leu Asp Trp Lys Arg  Thr Leu Ala 
    1415                 1420                 1425             


Ile His  Leu Trp Tyr Leu Leu  Pro Pro Thr Ala Ser  Ile Ser Arg 
    1430                 1435                 1440             


Ala Leu  Ser Met Tyr Glu Glu  Ala Phe Gln Asn Thr  Pro Glu Gly 
    1445                 1450                 1455             


Asp Lys  Tyr Ala Cys Ser Pro  Leu Pro Ser Tyr Leu  Glu Gly Cys 
    1460                 1465                 1470             


Gly Cys  Met Val Glu Glu Glu  Lys Asp Ser Arg Arg  Pro Leu Gln 
    1475                 1480                 1485             


Asp Val  Cys Phe His Leu Leu  Lys Leu Tyr Ser Asp  Arg His Tyr 
    1490                 1495                 1500             


Glu Leu  Asn Gln Leu Leu Glu  Pro Arg Ser Ile Thr  Ala Asp Pro 
    1505                 1510                 1515             


Leu Asp  Tyr Arg Leu Ser Trp  His Leu Trp Glu Val  Leu Arg Ala 
    1520                 1525                 1530             


Leu Asn  Tyr Thr His Leu Ser  Glu Gln Cys Glu Gly  Val Leu Gln 
    1535                 1540                 1545             


Ala Ser  Tyr Ala Gly Gln Leu  Glu Ser Glu Gly Leu  Trp Glu Trp 
    1550                 1555                 1560             


Ala Ile  Phe Val Phe Leu His  Ile Asp Asn Ser Gly  Met Arg Glu 
    1565                 1570                 1575             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Ser Glu 
    1580                 1585                 1590             


Thr Pro  Glu Ser Trp Ala Lys  Glu Ala Phe Leu Thr  Gln Lys Leu 
    1595                 1600                 1605             


Cys Val  Pro Ala Glu Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1610                 1615                 1620             


His Met  Glu Ser Asn Lys His  Leu Glu Ala Leu Tyr  Leu Phe Lys 
    1625                 1630                 1635             


Ala Gly  His Trp Asn Arg Cys  His Lys Leu Val Ile  Arg His Leu 
    1640                 1645                 1650             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1655                 1660                 1665             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1670                 1675                 1680             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1685                 1690                 1695             


Ile Glu  Met Leu His Arg Ile  Gln Gln Val Asp Cys  Ser Gly Tyr 
    1700                 1705                 1710             


Glu Leu  Glu His Leu His Thr  Lys Val Thr Ser Leu  Cys Asn Arg 
    1715                 1720                 1725             


Ile Glu  Gln Ile Pro Cys Tyr  Asn Ala Lys Asp Arg  Leu Ala Gln 
    1730                 1735                 1740             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1745                 1750                 1755             


Ser Leu  Gln His Ala Pro Asp  Ala Thr Ser Asn Ser  Thr Pro Asp 
    1760                 1765                 1770             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1775                 1780                 1785             


Leu Pro  Met Pro Glu Asp Tyr  Ala Leu Glu Glu Leu  Arg Gly Leu 
    1790                 1795                 1800             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Thr Val Gly Ser  Gln 
    1805                 1810                 1815     


<210>  53
<211>  1170
<212>  PRT
<213>  Mus musculus

<400>  53

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Ser Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Gly Gly Thr Thr 
    210                 215                 220                 


Ala Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Asn Ser Gly Ser 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn Asn Gln Gln Asp Gly Glu Asp Asp Ser Leu Val Ser Arg 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Val Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ala Tyr His Ile His Pro Ala Gly Ile Val Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile Val 
    770                 775                 780                 


Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Pro 
865                 870                 875                 880 


Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Gly 
                885                 890                 895     


Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu 
        915                 920                 925             


Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp Ser 
    930                 935                 940                 


Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala Ser 
945                 950                 955                 960 


Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile 
                965                 970                 975     


Met Lys Ala Ser Leu Leu Val Asp Glu Glu Asp Val Asp Ala Met Asp 
            980                 985                 990         


Gln Arg Phe Gly His Ile Pro Ser  Lys Gly Glu Thr Val  Gln Glu Ile 
        995                 1000                 1005             


Cys Ser  Pro Arg Leu Pro Ile  Ser Ala Ser His Ser  Ser Lys Ser 
    1010                 1015                 1020             


Arg Ser  Ile Val Gly Gly Leu  Leu Gln Ser Lys Phe  Ala Ser Gly 
    1025                 1030                 1035             


Thr Phe  Leu Ser Pro Ser Ala  Ser Val Gln Glu Cys  Arg Thr Pro 
    1040                 1045                 1050             


Arg Thr  Ser Ser Arg Met Asn  Ile Pro Ser Thr Ser  Pro Trp Ser 
    1055                 1060                 1065             


Val Pro  Leu Pro Leu Ala Thr  Val Phe Thr Val Pro  Ser Pro Ala 
    1070                 1075                 1080             


Pro Glu  Val Gln Leu Lys Thr  Val Gly Ile Arg Arg  Gln Pro Gly 
    1085                 1090                 1095             


Leu Val  Pro Leu Glu Lys Ser  Ile Thr Tyr Gly Lys  Gly Lys Leu 
    1100                 1105                 1110             


Leu Met  Asp Met Ala Leu Phe  Met Gly Arg Ser Phe  Arg Val Gly 
    1115                 1120                 1125             


Trp Gly  Pro Asn Trp Thr Leu  Ala Asn Ser Gly Glu  Gln Leu His 
    1130                 1135                 1140             


Gly Ser  His Glu Leu Glu Asn  His Gln Val Ala Asp  Ser Met Glu 
    1145                 1150                 1155             


Tyr Gly  Phe Leu Pro Asn Pro  Val Ala Val Lys Ser  
    1160                 1165                 1170 


<210>  54
<211>  1187
<212>  PRT
<213>  Mus musculus

<400>  54

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Ser Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Gly Gly Thr Thr 
    210                 215                 220                 


Ala Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Asn Ser Gly 
                405                 410                 415     


Ser Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn Asn Gln Gln Asp Gly Glu Asp Asp Ser Leu Val Ser 
                645                 650                 655     


Arg Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Val Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ala Tyr His Ile His Pro Ala Gly Ile Val Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile 
785                 790                 795                 800 


Val Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Pro Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Gly Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp 
945                 950                 955                 960 


Ser Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Val  Asp Glu Glu Asp Val  Asp Ala Met 
        995                 1000                 1005             


Asp Gln  Arg Phe Gly His Ile  Pro Ser Lys Gly Glu  Thr Val Gln 
    1010                 1015                 1020             


Glu Ile  Cys Ser Pro Arg Leu  Pro Ile Ser Ala Ser  His Ser Ser 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Val Gly  Gly Leu Leu Gln Ser  Lys Phe Ala 
    1040                 1045                 1050             


Ser Gly  Thr Phe Leu Ser Pro  Ser Ala Ser Val Gln  Glu Cys Arg 
    1055                 1060                 1065             


Thr Pro  Arg Thr Ser Ser Arg  Met Asn Ile Pro Ser  Thr Ser Pro 
    1070                 1075                 1080             


Trp Ser  Val Pro Leu Pro Leu  Ala Thr Val Phe Thr  Val Pro Ser 
    1085                 1090                 1095             


Pro Ala  Pro Glu Val Gln Leu  Lys Thr Val Gly Ile  Arg Arg Gln 
    1100                 1105                 1110             


Pro Gly  Leu Val Pro Leu Glu  Lys Ser Ile Thr Tyr  Gly Lys Gly 
    1115                 1120                 1125             


Lys Leu  Leu Met Asp Met Ala  Leu Phe Met Gly Arg  Ser Phe Arg 
    1130                 1135                 1140             


Val Gly  Trp Gly Pro Asn Trp  Thr Leu Ala Asn Ser  Gly Glu Gln 
    1145                 1150                 1155             


Leu His  Gly Ser His Glu Leu  Glu Asn His Gln Val  Ala Asp Ser 
    1160                 1165                 1170             


Met Glu  Tyr Gly Phe Leu Pro  Asn Pro Val Ala Val  Lys Ser 
    1175                 1180                 1185         


<210>  55
<211>  1816
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Asn 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Asn Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Asn Ser Gly 
                405                 410                 415     


Ser Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn His Gln Gln Asp Gly Asp Asp Asp Ser Leu Val Ser 
                645                 650                 655     


Arg Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Ala Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Phe 
        675                 680                 685             


Ile Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Asp 
705                 710                 715                 720 


Glu Ile Glu Asn Ser Ala Phe Gln Ile His Pro Ala Gly Ile Val Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile 
785                 790                 795                 800 


Val Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Pro Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Gly Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp 
945                 950                 955                 960 


Ser Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr Gln Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Val  Asp Glu Glu Asp Val  Asp Ala Met 
        995                 1000                 1005             


Glu Gln  Arg Phe Gly His Phe  Pro Ser Arg Gly Asp  Thr Ala Gln 
    1010                 1015                 1020             


Glu Ile  Cys Ser Pro Arg Leu  Pro Ile Ser Ala Ser  His Ser Ser 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Val Gly  Gly Leu Leu Gln Ser  Lys Phe Ala 
    1040                 1045                 1050             


Ser Gly  Thr Phe Leu Ser Pro  Ser Ala Ser Val Gln  Glu Cys Arg 
    1055                 1060                 1065             


Thr Pro  Arg Thr Ser Ser Leu  Met Asn Val Pro Ser  Thr Ser Pro 
    1070                 1075                 1080             


Trp Ser  Val Pro Leu Pro Leu  Ala Thr Val Phe Thr  Val Pro Ser 
    1085                 1090                 1095             


Pro Ala  Pro Glu Val Pro Leu  Lys Thr Val Gly Ile  Arg Arg Gln 
    1100                 1105                 1110             


Pro Gly  Leu Val Pro Leu Glu  Lys Ser Ile Thr Tyr  Gly Lys Gly 
    1115                 1120                 1125             


Lys Leu  Leu Met Asp Met Ala  Leu Phe Met Gly Arg  Ser Phe Arg 
    1130                 1135                 1140             


Val Gly  Trp Gly Pro Asn Trp  Thr Leu Ala Asn Ser  Gly Glu Gln 
    1145                 1150                 1155             


Leu His  Gly Ser His Glu Leu  Glu Asn His Gln Val  Ala Glu Ser 
    1160                 1165                 1170             


Met Glu  Tyr Gly Phe Leu Pro  Asn Pro Val Ala Val  Lys Ser Leu 
    1175                 1180                 1185             


Ser Glu  Ser Pro Phe Lys Val  His Leu Glu Lys Leu  Gly Leu Arg 
    1190                 1195                 1200             


Gln Arg  Lys Leu Asp Glu Asp  Leu Gln Leu Tyr Gln  Thr Pro Leu 
    1205                 1210                 1215             


Glu Leu  Lys Leu Lys His Ser  Thr Val His Val Asp  Glu Leu Cys 
    1220                 1225                 1230             


Pro Leu  Ile Val Pro Asn Pro  Gly Val Ser Val Ile  His Gly Tyr 
    1235                 1240                 1245             


Ala Asp  Trp Val Lys Lys Ser  Pro Arg Asp Leu Leu  Glu Leu Pro 
    1250                 1255                 1260             


Ile Val  Lys His Trp Ser Leu  Thr Trp Thr Leu Cys  Glu Ala Leu 
    1265                 1270                 1275             


Trp Gly  His Leu Lys Glu Leu  Asp Ser Gln Leu Asp  Glu Pro Ser 
    1280                 1285                 1290             


Glu Tyr  Ile Gln Thr Leu Glu  Arg Arg Arg Ala Phe  Ser Arg Trp 
    1295                 1300                 1305             


Leu Ser  His Thr Ala Ala Pro  Gln Ile Glu Glu Glu  Val Ser Leu 
    1310                 1315                 1320             


Thr Arg  Arg Asp Ser Pro Ile  Glu Ala Val Phe Ser  Tyr Leu Thr 
    1325                 1330                 1335             


Gly Ser  Arg Ile Ser Glu Ala  Cys Cys Leu Ala Gln  Gln Ser Gly 
    1340                 1345                 1350             


Asp His  Arg Leu Ala Leu Leu  Leu Ser Gln Leu Val  Gly Ser Gln 
    1355                 1360                 1365             


Ser Val  Arg Glu Leu Leu Thr  Met Gln Leu Ala Asp  Trp His Gln 
    1370                 1375                 1380             


Leu Gln  Ala Asp Ser Phe Ile  His Asp Glu Arg Leu  Arg Ile Phe 
    1385                 1390                 1395             


Ala Leu  Leu Ala Gly Lys Pro  Val Trp Gln Leu Ser  Glu Gln Lys 
    1400                 1405                 1410             


Gln Ile  Asn Val Cys Ser Gln  Leu Asp Trp Lys Arg  Thr Leu Ala 
    1415                 1420                 1425             


Ile His  Leu Trp Tyr Leu Leu  Pro Pro Thr Ala Ser  Ile Ser Arg 
    1430                 1435                 1440             


Ala Leu  Ser Met Tyr Glu Glu  Ala Phe Gln Asn Thr  Cys Glu Gly 
    1445                 1450                 1455             


Asp Lys  Tyr Ala Cys Pro Pro  Leu Pro Ser Tyr Leu  Glu Gly Ser 
    1460                 1465                 1470             


Gly Cys  Val Val Glu Glu Glu  Lys Asp Pro Gln Arg  Pro Leu Gln 
    1475                 1480                 1485             


Asp Val  Cys Phe His Leu Leu  Lys Leu Tyr Ser Asp  Arg His Tyr 
    1490                 1495                 1500             


Gly Leu  Asn Gln Leu Leu Glu  Pro Arg Ser Ile Thr  Ala Asp Pro 
    1505                 1510                 1515             


Leu Asp  Tyr Arg Leu Ser Trp  His Leu Trp Glu Val  Leu Arg Ala 
    1520                 1525                 1530             


Leu Asn  Tyr Thr His Leu Ser  Glu Gln Cys Glu Gly  Val Leu Gln 
    1535                 1540                 1545             


Ala Ser  Tyr Ala Gly Gln Leu  Glu Ser Glu Gly Leu  Trp Glu Trp 
    1550                 1555                 1560             


Ala Ile  Phe Val Phe Leu His  Ile Asp Asn Ser Gly  Met Arg Glu 
    1565                 1570                 1575             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Ser Glu 
    1580                 1585                 1590             


Thr Pro  Glu Ser Trp Ala Lys  Glu Thr Phe Leu Thr  Gln Lys Leu 
    1595                 1600                 1605             


Cys Val  Pro Ala Glu Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1610                 1615                 1620             


His Met  Glu Ser Asn Lys His  Leu Glu Ala Leu Tyr  Leu Phe Lys 
    1625                 1630                 1635             


Ala Gly  His Trp Asn Arg Cys  His Lys Leu Val Val  Arg His Leu 
    1640                 1645                 1650             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1655                 1660                 1665             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1670                 1675                 1680             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1685                 1690                 1695             


Ile Glu  Met Leu His Arg Ile  Gln Gln Val Asp Cys  Ser Gly Tyr 
    1700                 1705                 1710             


Glu Leu  Glu His Leu His Thr  Lys Val Thr Ser Leu  Cys Asn Arg 
    1715                 1720                 1725             


Ile Glu  Gln Ile Pro Cys Tyr  Asn Ala Lys Asp Arg  Leu Ala Gln 
    1730                 1735                 1740             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1745                 1750                 1755             


Ser Leu  Gln His Thr Pro Asp  Ala Thr Ser Asn Ser  Thr Pro Asp 
    1760                 1765                 1770             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1775                 1780                 1785             


Leu Pro  Met Pro Glu Asp Tyr  Ala Leu Glu Glu Leu  Arg Gly Leu 
    1790                 1795                 1800             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Thr Val Gly Ser  Gln 
    1805                 1810                 1815     


<210>  56
<211>  1816
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ser Asn Ser Leu Phe Gly Thr Ala Asn 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Asn Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Ala Phe Ser Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Pro Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Leu Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Pro Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Thr Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Asn Ser Gly 
                405                 410                 415     


Ser Ser Ile Phe Gly Ser Lys Pro Ala Ala Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Thr Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Ser Thr Ala Ile Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Leu Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn His Asp Ser Glu Asp Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn His Gln Gln Asp Gly Asp Asp Asp Ser Leu Val Ser 
                645                 650                 655     


Arg Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Ala Gly Asn Lys Asn Asn Ser Ser Ser Asn Val Glu Asp Thr Phe 
        675                 680                 685             


Ile Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Asp 
705                 710                 715                 720 


Glu Ile Glu Asn Ser Ala Phe Gln Ile His Pro Ala Gly Ile Val Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Ile 
785                 790                 795                 800 


Val Tyr Val Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Pro Lys Thr Thr Ser Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Gly Gln Ala Thr Thr Phe Gln Met Thr Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val 
    930                 935                 940                 


Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Pro Asp 
945                 950                 955                 960 


Ser Val Leu Glu Glu Ser Val Pro Glu Asp Gln Glu Pro Val Ser Ala 
                965                 970                 975     


Ser Thr Gln Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln 
            980                 985                 990         


Ile Met Lys Ala Ser Leu Leu Val  Asp Glu Glu Asp Val  Asp Ala Met 
        995                 1000                 1005             


Glu Gln  Arg Phe Gly His Phe  Pro Ser Arg Gly Asp  Thr Ala Gln 
    1010                 1015                 1020             


Glu Ile  Cys Ser Pro Arg Leu  Pro Ile Ser Ala Ser  His Ser Ser 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Val Gly  Gly Leu Leu Gln Ser  Lys Phe Ala 
    1040                 1045                 1050             


Ser Gly  Thr Phe Leu Ser Pro  Ser Ala Ser Val Gln  Glu Cys Arg 
    1055                 1060                 1065             


Thr Pro  Arg Thr Ser Ser Leu  Met Asn Val Pro Ser  Thr Ser Pro 
    1070                 1075                 1080             


Trp Ser  Val Pro Leu Pro Leu  Ala Thr Val Phe Thr  Val Pro Ser 
    1085                 1090                 1095             


Pro Ala  Pro Glu Val Pro Leu  Lys Thr Val Gly Ile  Arg Arg Gln 
    1100                 1105                 1110             


Pro Gly  Leu Val Pro Leu Glu  Lys Ser Ile Thr Tyr  Gly Lys Gly 
    1115                 1120                 1125             


Lys Leu  Leu Met Asp Met Ala  Leu Phe Met Gly Arg  Ser Phe Arg 
    1130                 1135                 1140             


Val Gly  Trp Gly Pro Asn Trp  Thr Leu Ala Asn Ser  Gly Glu Gln 
    1145                 1150                 1155             


Leu His  Gly Ser His Glu Leu  Glu Asn His Gln Val  Ala Glu Ser 
    1160                 1165                 1170             


Met Glu  Tyr Gly Phe Leu Pro  Asn Pro Val Ala Val  Lys Ser Leu 
    1175                 1180                 1185             


Ser Glu  Ser Pro Phe Lys Val  His Leu Glu Lys Leu  Gly Leu Arg 
    1190                 1195                 1200             


Gln Arg  Lys Leu Asp Glu Asp  Leu Gln Leu Tyr Gln  Thr Pro Leu 
    1205                 1210                 1215             


Glu Leu  Lys Leu Lys His Ser  Thr Val His Val Asp  Glu Leu Cys 
    1220                 1225                 1230             


Pro Leu  Ile Val Pro Asn Pro  Gly Val Ser Val Ile  His Gly Tyr 
    1235                 1240                 1245             


Ala Asp  Trp Val Lys Lys Ser  Pro Arg Asp Leu Leu  Glu Leu Pro 
    1250                 1255                 1260             


Ile Val  Lys His Trp Ser Leu  Thr Trp Thr Leu Cys  Glu Ala Leu 
    1265                 1270                 1275             


Trp Gly  His Leu Lys Glu Leu  Asp Ser Gln Leu Asp  Glu Pro Ser 
    1280                 1285                 1290             


Glu Tyr  Ile Gln Thr Leu Glu  Arg Arg Arg Ala Phe  Ser Arg Trp 
    1295                 1300                 1305             


Leu Ser  His Thr Ala Ala Pro  Gln Ile Glu Glu Glu  Val Ser Leu 
    1310                 1315                 1320             


Thr Arg  Arg Asp Ser Pro Ile  Glu Ala Val Phe Ser  Tyr Leu Thr 
    1325                 1330                 1335             


Gly Ser  Arg Ile Ser Glu Ala  Cys Cys Leu Ala Gln  Gln Ser Gly 
    1340                 1345                 1350             


Asp His  Arg Leu Ala Leu Leu  Leu Ser Gln Leu Val  Gly Ser Gln 
    1355                 1360                 1365             


Ser Val  Arg Glu Leu Leu Thr  Met Gln Leu Ala Asp  Trp His Gln 
    1370                 1375                 1380             


Leu Gln  Ala Asp Ser Phe Ile  His Asp Glu Arg Leu  Arg Ile Phe 
    1385                 1390                 1395             


Ala Leu  Leu Ala Gly Lys Pro  Val Trp Gln Leu Ser  Glu Gln Lys 
    1400                 1405                 1410             


Gln Ile  Asn Val Cys Ser Gln  Leu Asp Trp Lys Arg  Thr Leu Ala 
    1415                 1420                 1425             


Ile His  Leu Trp Tyr Leu Leu  Pro Pro Thr Ala Ser  Ile Ser Arg 
    1430                 1435                 1440             


Ala Leu  Ser Met Tyr Glu Glu  Ala Phe Gln Asn Thr  Cys Glu Gly 
    1445                 1450                 1455             


Asp Lys  Tyr Ala Cys Pro Pro  Leu Pro Ser Tyr Leu  Glu Gly Ser 
    1460                 1465                 1470             


Gly Cys  Val Val Glu Glu Glu  Lys Asp Pro Gln Arg  Pro Leu Gln 
    1475                 1480                 1485             


Asp Val  Cys Phe His Leu Leu  Lys Leu Tyr Ser Asp  Arg His Tyr 
    1490                 1495                 1500             


Gly Leu  Asn Gln Leu Leu Glu  Pro Arg Ser Ile Thr  Ala Asp Pro 
    1505                 1510                 1515             


Leu Asp  Tyr Arg Leu Ser Trp  His Leu Trp Glu Val  Leu Arg Ala 
    1520                 1525                 1530             


Leu Asn  Tyr Thr His Leu Ser  Glu Gln Cys Glu Gly  Val Leu Gln 
    1535                 1540                 1545             


Ala Ser  Tyr Ala Gly Gln Leu  Glu Ser Glu Gly Leu  Trp Glu Trp 
    1550                 1555                 1560             


Ala Ile  Phe Val Phe Leu His  Ile Asp Asn Ser Gly  Met Arg Glu 
    1565                 1570                 1575             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Ser Glu 
    1580                 1585                 1590             


Thr Pro  Glu Ser Trp Ala Lys  Glu Thr Phe Leu Thr  Gln Lys Leu 
    1595                 1600                 1605             


Cys Val  Pro Ala Glu Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1610                 1615                 1620             


His Met  Glu Ser Asn Lys His  Leu Glu Ala Leu Tyr  Leu Phe Lys 
    1625                 1630                 1635             


Ala Gly  His Trp Asn Arg Cys  His Lys Leu Val Val  Arg His Leu 
    1640                 1645                 1650             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1655                 1660                 1665             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1670                 1675                 1680             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1685                 1690                 1695             


Ile Glu  Met Leu His Arg Ile  Gln Gln Val Asp Cys  Ser Gly Tyr 
    1700                 1705                 1710             


Glu Leu  Glu His Leu His Thr  Lys Val Thr Ser Leu  Cys Asn Arg 
    1715                 1720                 1725             


Ile Glu  Gln Ile Pro Cys Tyr  Asn Ala Lys Asp Arg  Leu Ala Gln 
    1730                 1735                 1740             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1745                 1750                 1755             


Ser Leu  Gln His Thr Pro Asp  Ala Thr Ser Asn Ser  Thr Pro Asp 
    1760                 1765                 1770             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1775                 1780                 1785             


Leu Pro  Met Pro Glu Asp Tyr  Ala Leu Glu Glu Leu  Arg Gly Leu 
    1790                 1795                 1800             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Thr Val Gly Ser  Gln 
    1805                 1810                 1815     


<210>  57
<211>  1182
<212>  PRT
<213>  Mus musculus

<400>  57

Met Glu Glu Ser Gln Ser Lys Gln Glu Ser Ser Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Glu Asp Val Asp Pro Thr Phe Lys Thr Lys Lys Leu 
            20                  25                  30          


Met Glu Val Glu Leu Met Lys His Arg Val Gln Leu Glu Arg Asn Leu 
        35                  40                  45              


Lys Leu Arg Thr Phe Pro Gly Ala Arg Thr Lys Gln Val Lys Glu Ala 
    50                  55                  60                  


Leu Tyr Pro Leu Leu Thr Trp Ser Ser Lys Ser Lys Asn Leu Phe Gln 
65                  70                  75                  80  


Asn Phe Thr Lys Leu Leu Leu Phe Lys Lys Leu Cys Gln Arg Gly Ser 
                85                  90                  95      


Glu Asn Leu Val Arg Glu Ser Trp Tyr Pro Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ala His Met Ile Asp Ile Gln Asp Leu Phe Gly Pro Asn Leu Gly Thr 
        115                 120                 125             


Gln Lys Lys Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly 
    130                 135                 140                 


Lys Ser Thr Leu Ala Arg Leu Val Lys Arg Ala Trp Lys Glu Gly Lys 
145                 150                 155                 160 


Leu Tyr Arg Asn Asp Phe His His Val Phe Phe Phe Ser Cys Arg Glu 
                165                 170                 175     


Leu Ala Gln Tyr Glu Gln Leu Ser Leu Ala Glu Leu Ile Val Gln Gly 
            180                 185                 190         


Gln Glu Val Pro Thr Ala Pro Ile Arg Gln Ile Leu Ser His Pro Glu 
        195                 200                 205             


Lys Leu Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu 
    210                 215                 220                 


Ala Asp Gln Asn Pro Glu Leu Cys Leu His Trp Ser Gln Thr Gln Pro 
225                 230                 235                 240 


Val His Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Gly 
                245                 250                 255     


Ala Ser Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile 
            260                 265                 270         


Pro Ser Leu Glu Gln Pro Cys Gln Val Glu Val Leu Gly Phe Thr Leu 
        275                 280                 285             


Phe Glu Arg Lys Asn Tyr Phe Tyr Lys Tyr Phe Gly Lys Lys Lys Gly 
    290                 295                 300                 


Gly Val Thr Thr Phe Thr Leu Val Lys Ser Asn Ser Ala Leu Leu Thr 
305                 310                 315                 320 


Leu Cys Glu Val Pro Trp Val Cys Trp Leu Val Cys Thr Cys Leu Lys 
                325                 330                 335     


Lys Gln Met Glu Gln Gly Gly Glu Leu Ser Leu Thr Ser Gln Thr Thr 
            340                 345                 350         


Thr Ala Leu Cys Leu Lys Tyr Leu Ser Leu Thr Ile Pro Gly Gln His 
        355                 360                 365             


Met Arg Thr Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala Glu Gly Val 
    370                 375                 380                 


Cys Gln Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly 
385                 390                 395                 400 


Leu Asp Glu His Ala Ile Ala Ser Phe Leu Lys Ile Gly Val Leu Gln 
                405                 410                 415     


Lys Gln Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln 
            420                 425                 430         


Glu Phe Phe Ala Ala Met Ser Tyr Ile Leu Asp Asp Ser Glu Glu Arg 
        435                 440                 445             


His Ala Asp Met Lys Asn Asp Arg Ile Val Glu Thr Leu Val Glu Arg 
    450                 455                 460                 


Tyr Gly Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe 
465                 470                 475                 480 


Gly Leu Leu Ser Lys Glu Glu Leu Lys Lys Ile Glu Lys Leu Phe Ser 
                485                 490                 495     


Cys Ser Leu His Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu 
            500                 505                 510         


Gly Lys Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys 
        515                 520                 525             


Leu Tyr Glu Asn Gln Asp Met Glu Leu Leu Thr His Val Met His Asp 
    530                 535                 540                 


Leu Gln Gly Thr Ile Val Pro Gly Pro Asp Asp Leu Ala His Thr Val 
545                 550                 555                 560 


Leu Gln Thr Asn Val Lys His Leu Val Ile Gln Thr Asp Met Asp Leu 
                565                 570                 575     


Met Val Val Thr Phe Cys Ile Lys Phe Cys Cys His Val Arg Ser Leu 
            580                 585                 590         


Gln Leu Asn Arg Lys Val Gln Gln Gly His Lys Phe Thr Ala Pro Gly 
        595                 600                 605             


Met Val Leu Tyr Arg Trp Thr Pro Ile Thr Asp Ala Ser Trp Lys Ile 
    610                 615                 620                 


Phe Phe Ser Asn Leu Lys Leu Ala Arg Asn Leu Glu Glu Leu Asp Leu 
625                 630                 635                 640 


Ser Gly Asn Pro Leu Ser Tyr Tyr Ala Val His Ser Leu Cys Thr Thr 
                645                 650                 655     


Leu Arg Lys Arg Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys 
            660                 665                 670         


Gly Leu Thr Ser Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala 
        675                 680                 685             


Arg Ser Ser Leu Thr Glu Leu Asp Leu Gln Leu Asn Asp Leu Gly Asp 
    690                 695                 700                 


Gly Gly Val Lys Met Leu Cys Glu Gly Leu Arg Asn Pro Ala Cys Asn 
705                 710                 715                 720 


Leu Ser Ile Leu Trp Leu Asp Gln Ala Ser Leu Ser Asp Gln Val Ile 
                725                 730                 735     


Ala Glu Leu Arg Thr Leu Glu Ala Lys Asn Pro Lys Leu Leu Ile Ser 
            740                 745                 750         


Ser Thr Trp Lys Pro His Val Met Val Pro Thr Met Asn Met Asp Lys 
        755                 760                 765             


Glu Glu Val Gly Asp Ser Gln Ala Leu Leu Lys Gln Gln Arg Gln Gln 
    770                 775                 780                 


Ser Gly Asp Lys His Met Glu Pro Leu Gly Thr Glu Asp Glu Phe Trp 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Val Thr Thr Glu Val Val Asp Arg Glu Arg Asn 
                805                 810                 815     


Leu Tyr Arg Val Gln Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser 
            820                 825                 830         


Thr Gly Leu His Phe Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu 
        835                 840                 845             


Phe Cys Ala Trp Ser Gln Tyr Leu Asp Lys Thr Pro Leu Gln Gln Ser 
    850                 855                 860                 


His Met Val Val Gly Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala 
865                 870                 875                 880 


Val Thr Ala Val Tyr Leu Pro His Phe Val Ala Leu Gln Glu Gly Ile 
                885                 890                 895     


Val Asp Ser Ser Leu Phe His Val Ala His Phe Gln Glu His Gly Met 
            900                 905                 910         


Val Leu Glu Thr Pro Ala Arg Val Glu Gln His Tyr Ala Val Leu Glu 
        915                 920                 925             


Asn Pro Ser Phe Ser Pro Met Gly Ile Leu Leu Arg Met Ile Pro Ala 
    930                 935                 940                 


Val Gly His Phe Ile Pro Ile Thr Ser Thr Thr Leu Ile Tyr Tyr His 
945                 950                 955                 960 


Leu Tyr Leu Glu Asp Val Thr Phe His Leu Tyr Leu Val Pro Asn Asp 
                965                 970                 975     


Cys Ser Ile Arg Lys Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe 
            980                 985                 990         


Val Arg Ile Asn Lys Pro Pro Pro  Val Asp Ala Leu Tyr  Leu Gly Ser 
        995                 1000                 1005             


Arg Tyr  Ile Val Ser Ser Ser  Lys Leu Val Glu Ile  Ile Pro Lys 
    1010                 1015                 1020             


Glu Leu  Glu Leu Cys Tyr Arg  Ser Pro Gly Glu Ser  Gln Leu Phe 
    1025                 1030                 1035             


Ser Glu  Ile Asp Ile Gly His  Met Asp Ser Glu Ile  Lys Leu Gln 
    1040                 1045                 1050             


Ile Lys  Asp Lys Arg His Met  Asn Leu Lys Trp Glu  Ala Leu Leu 
    1055                 1060                 1065             


Lys Pro  Gly Asp Leu Arg Pro  Ala Leu Pro Lys Ile  Ala Thr Ala 
    1070                 1075                 1080             


Pro Lys  Asp Ala Pro Ser Leu  Leu His Phe Met Asp  Gln His Arg 
    1085                 1090                 1095             


Glu Gln  Leu Val Ala Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp 
    1100                 1105                 1110             


Lys Leu  His Gly Leu Val Leu  Ser Glu Asp Ser Tyr  Glu Val Val 
    1115                 1120                 1125             


Arg Ser  Glu Thr Thr Asn Gln  Asp Lys Met Arg Lys  Leu Phe Ser 
    1130                 1135                 1140             


Leu Ser  Arg Ser Trp Ser Trp  Asp Cys Lys Asp Gln  Phe Tyr Gln 
    1145                 1150                 1155             


Ala Leu  Lys Glu Thr His Pro  His Leu Val Met Asp  Ile Leu Glu 
    1160                 1165                 1170             


Lys Leu  Gly Gly Val Ser Val  Lys Ser 
    1175                 1180         


<210>  58
<211>  1182
<212>  PRT
<213>  Mus musculus

<400>  58

Met Glu Glu Ser Gln Ser Lys Gln Glu Ser Ser Thr Lys Val Ala Gln 
1               5                   10                  15      


His Glu Gly Gln Glu Asp Val Asp Pro Thr Phe Lys Thr Lys Lys Leu 
            20                  25                  30          


Met Glu Val Glu Leu Met Lys His Arg Val Gln Leu Glu Arg Asn Leu 
        35                  40                  45              


Lys Leu Arg Thr Phe Pro Gly Ala Arg Thr Lys Gln Val Lys Glu Ala 
    50                  55                  60                  


Leu Tyr Pro Leu Leu Thr Trp Ser Ser Lys Ser Lys Asn Leu Phe Gln 
65                  70                  75                  80  


Asn Phe Thr Lys Leu Leu Leu Phe Lys Lys Leu Cys Gln Arg Gly Ser 
                85                  90                  95      


Glu Asn Leu Val Arg Glu Ser Trp Tyr Pro Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ala His Met Ile Asp Ile Gln Asp Leu Phe Gly Pro Asn Leu Gly Thr 
        115                 120                 125             


Gln Lys Lys Pro Gln Leu Val Ile Ile Glu Gly Ala Ala Gly Ile Gly 
    130                 135                 140                 


Lys Ser Thr Leu Ala Arg Leu Val Lys Arg Ala Trp Lys Glu Gly Lys 
145                 150                 155                 160 


Leu Tyr Arg Asn Asp Phe His His Val Phe Phe Phe Ser Cys Arg Glu 
                165                 170                 175     


Leu Ala Gln Tyr Glu Gln Leu Ser Leu Ala Glu Leu Ile Val Gln Gly 
            180                 185                 190         


Gln Glu Val Pro Thr Ala Pro Ile Arg Gln Ile Leu Ser His Pro Glu 
        195                 200                 205             


Lys Leu Leu Phe Ile Leu Asp Gly Ile Asp Glu Pro Ala Trp Val Leu 
    210                 215                 220                 


Ala Asp Gln Asn Pro Glu Leu Cys Leu His Trp Ser Gln Thr Gln Pro 
225                 230                 235                 240 


Val His Thr Leu Leu Gly Ser Leu Leu Gly Lys Ser Ile Leu Pro Gly 
                245                 250                 255     


Ala Ser Phe Leu Leu Thr Thr Arg Thr Thr Ala Leu Gln Lys Phe Ile 
            260                 265                 270         


Pro Ser Leu Glu Gln Pro Cys Gln Val Glu Val Leu Gly Phe Thr Leu 
        275                 280                 285             


Phe Glu Arg Lys Asn Tyr Phe Tyr Lys Tyr Phe Gly Lys Lys Lys Gly 
    290                 295                 300                 


Gly Val Thr Thr Phe Thr Leu Val Lys Ser Asn Ser Ala Leu Leu Thr 
305                 310                 315                 320 


Leu Cys Glu Val Pro Trp Val Cys Trp Leu Val Cys Thr Cys Leu Lys 
                325                 330                 335     


Lys Gln Met Glu Gln Gly Gly Glu Leu Ser Leu Thr Ser Gln Thr Thr 
            340                 345                 350         


Thr Ala Leu Cys Leu Lys Tyr Leu Ser Leu Thr Ile Pro Gly Gln His 
        355                 360                 365             


Met Arg Thr Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala Glu Gly Val 
    370                 375                 380                 


Cys Gln Arg Arg Thr Leu Phe Ser Glu Ser Asp Leu Cys Lys Gln Gly 
385                 390                 395                 400 


Leu Asp Glu His Ala Ile Ala Ser Phe Leu Lys Ile Gly Val Leu Gln 
                405                 410                 415     


Lys Gln Ala Ser Ser Leu Ser Tyr Ser Phe Ala His Leu Cys Leu Gln 
            420                 425                 430         


Glu Phe Phe Ala Ala Met Ser Tyr Ile Leu Asp Asp Ser Glu Glu Arg 
        435                 440                 445             


His Ala Asp Met Lys Asn Asp Arg Ile Val Glu Thr Leu Val Glu Arg 
    450                 455                 460                 


Tyr Gly Arg Gln Asn Leu Phe Glu Ala Pro Thr Val Arg Phe Leu Phe 
465                 470                 475                 480 


Gly Leu Leu Ser Lys Glu Glu Leu Lys Lys Ile Glu Lys Leu Phe Ser 
                485                 490                 495     


Cys Ser Leu His Gly Lys Thr Lys Leu Lys Leu Leu Trp His Ile Leu 
            500                 505                 510         


Gly Lys Ser Gln Pro His Gln Pro Pro Cys Leu Gly Leu Leu His Cys 
        515                 520                 525             


Leu Tyr Glu Asn Gln Asp Met Glu Leu Leu Thr His Val Met His Asp 
    530                 535                 540                 


Leu Gln Gly Thr Ile Val Pro Gly Pro Asp Asp Leu Ala His Thr Val 
545                 550                 555                 560 


Leu Gln Thr Asn Val Lys His Leu Val Ile Gln Thr Asp Met Asp Leu 
                565                 570                 575     


Met Val Val Thr Phe Cys Ile Lys Phe Cys Cys His Val Arg Ser Leu 
            580                 585                 590         


Gln Leu Asn Arg Lys Val Gln Gln Gly His Lys Phe Thr Ala Pro Gly 
        595                 600                 605             


Met Val Leu Tyr Arg Trp Thr Pro Ile Thr Asp Ala Ser Trp Lys Ile 
    610                 615                 620                 


Phe Phe Ser Asn Leu Lys Leu Ala Arg Asn Leu Glu Glu Leu Asp Leu 
625                 630                 635                 640 


Ser Gly Asn Pro Leu Ser Tyr Tyr Ala Val His Ser Leu Cys Thr Thr 
                645                 650                 655     


Leu Arg Lys Arg Gly Cys Gln Leu Lys Thr Leu Trp Leu Val Glu Cys 
            660                 665                 670         


Gly Leu Thr Ser Thr Tyr Cys Ser Leu Leu Ala Ser Val Leu Ser Ala 
        675                 680                 685             


Arg Ser Ser Leu Thr Glu Leu Asp Leu Gln Leu Asn Asp Leu Gly Asp 
    690                 695                 700                 


Gly Gly Val Lys Met Leu Cys Glu Gly Leu Arg Asn Pro Ala Cys Asn 
705                 710                 715                 720 


Leu Ser Ile Leu Trp Leu Asp Gln Ala Ser Leu Ser Asp Gln Val Ile 
                725                 730                 735     


Ala Glu Leu Arg Thr Leu Glu Ala Lys Asn Pro Lys Leu Leu Ile Ser 
            740                 745                 750         


Ser Thr Trp Lys Pro His Val Met Val Pro Thr Met Asn Met Asp Lys 
        755                 760                 765             


Glu Glu Val Gly Asp Ser Gln Ala Leu Leu Lys Gln Gln Arg Gln Gln 
    770                 775                 780                 


Ser Gly Asp Lys His Met Glu Pro Leu Gly Thr Glu Asp Glu Phe Trp 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Val Thr Thr Glu Val Val Asp Arg Glu Arg Asn 
                805                 810                 815     


Leu Tyr Arg Val Gln Leu Pro Met Ala Gly Ser Tyr His Cys Pro Ser 
            820                 825                 830         


Thr Gly Leu His Phe Val Val Thr Arg Ala Val Thr Ile Glu Ile Glu 
        835                 840                 845             


Phe Cys Ala Trp Ser Gln Tyr Leu Asp Lys Thr Pro Leu Gln Gln Ser 
    850                 855                 860                 


His Met Val Val Gly Pro Leu Phe Asp Ile Lys Ala Glu Gln Gly Ala 
865                 870                 875                 880 


Val Thr Ala Val Tyr Leu Pro His Phe Val Ala Leu Gln Glu Gly Ile 
                885                 890                 895     


Val Asp Ser Ser Leu Phe His Val Ala His Phe Gln Glu His Gly Met 
            900                 905                 910         


Val Leu Glu Thr Pro Ala Arg Val Glu Gln His Tyr Ala Val Leu Glu 
        915                 920                 925             


Asn Pro Ser Phe Ser Pro Met Gly Ile Leu Leu Arg Met Ile Pro Ala 
    930                 935                 940                 


Val Gly His Phe Ile Pro Ile Thr Ser Thr Thr Leu Ile Tyr Tyr His 
945                 950                 955                 960 


Leu Tyr Leu Glu Asp Val Thr Phe His Leu Tyr Leu Val Pro Asn Asp 
                965                 970                 975     


Cys Ser Ile Arg Lys Ala Ile Asp Asp Glu Glu Met Lys Phe Gln Phe 
            980                 985                 990         


Val Arg Ile Asn Lys Pro Pro Pro  Val Asp Ala Leu Tyr  Leu Gly Ser 
        995                 1000                 1005             


Arg Tyr  Ile Val Ser Ser Ser  Lys Leu Val Glu Ile  Ile Pro Lys 
    1010                 1015                 1020             


Glu Leu  Glu Leu Cys Tyr Arg  Ser Pro Gly Glu Ser  Gln Leu Phe 
    1025                 1030                 1035             


Ser Glu  Ile Asp Ile Gly His  Met Asp Ser Glu Ile  Lys Leu Gln 
    1040                 1045                 1050             


Ile Lys  Asp Lys Arg His Met  Asn Leu Lys Trp Glu  Ala Leu Leu 
    1055                 1060                 1065             


Lys Pro  Gly Asp Leu Arg Pro  Ala Leu Pro Lys Ile  Ala Thr Ala 
    1070                 1075                 1080             


Pro Lys  Asp Ala Pro Ser Leu  Leu His Phe Met Asp  Gln His Arg 
    1085                 1090                 1095             


Glu Gln  Leu Val Ala Arg Val  Thr Ser Val Asp Pro  Leu Leu Asp 
    1100                 1105                 1110             


Lys Leu  His Gly Leu Val Leu  Ser Glu Asp Ser Tyr  Glu Val Val 
    1115                 1120                 1125             


Arg Ser  Glu Thr Thr Asn Gln  Asp Lys Met Arg Lys  Leu Phe Ser 
    1130                 1135                 1140             


Leu Ser  Arg Ser Trp Ser Trp  Asp Cys Lys Asp Gln  Phe Tyr Gln 
    1145                 1150                 1155             


Ala Leu  Lys Glu Thr His Pro  His Leu Val Met Asp  Ile Leu Glu 
    1160                 1165                 1170             


Lys Leu  Gly Gly Val Ser Val  Lys Ser 
    1175                 1180         


