                               SEQUENCE LISTING

<110> VOYAGER THERAPEUTICS, INC.
 
<120> METHODS FOR MEASURING THE POTENCY OF AADC VIRAL VECTORS

<130> 2057.1058PCT

<140> PCT/US2019/XXXXXX
<141> 2019-04-26

<150> 62/741,463
<151> 2018-10-04

<150> 62/703,590
<151> 2018-07-26

<150> 62/663,958
<151> 2018-04-27

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 480
<212> PRT
<213> Homo sapiens

<400> 1
Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210> 2
<211> 3526
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctacgt      180

agccatgcgt cgacataacg cgtatatcta gacgttacat aacttacggt aaatggcccg      240

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      300

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      360

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      420

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      480

cagtacatct agtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca      540

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca      600

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg      660

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc      720

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa      780

gacaccggga ccgatccagc ctccgcggat tcgaatcccg gccgggaacg gtgcattgga      840

acgcggattc cccgtgccaa gagtgacgta agtaccgcct atagagtcta taggcccaca      900

aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat actttcccta      960

atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca ccattctaaa     1020

gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata taaatatttc     1080

tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc tacaatccag     1140

ctaccattct gcttttattt tatggttggg ataaggctgg attattctga gtccaagcta     1200

ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc tgggcaacgt     1260

gctggtctgt gtgctggccc atcactttgg caaagaattg ggattcgaac atcgattgaa     1320

ttccccgggg atccaccatg aacgcaagtg aattccgaag gagagggaag gagatggtgg     1380

attacgtggc caactacatg gaaggcattg agggacgcca ggtctaccct gacgtggagc     1440

ccgggtacct gcggccgctg atccctgccg ctgcccctca ggagccagac acgtttgagg     1500

acatcatcaa cgacgttgag aagataatca tgcctggggt gacgcactgg cacagcccct     1560

acttcttcgc ctacttcccc actgccagct cgtacccggc catgcttgcg gacatgctgt     1620

gcggggccat tggctgcatc ggcttctcct gggcggcaag cccagcatgc acagagctgg     1680

agactgtgat gatggactgg ctcgggaaga tgctggaact accaaaggca tttttgaatg     1740

agaaagctgg agaaggggga ggagtgatcc agggaagtgc cagtgaagcc accctggtgg     1800

ccctgctggc cgctcggacc aaagtgatcc atcggctgca ggcagcgtcc ccagagctca     1860

cacaggccgc tatcatggag aagctggtgg cttactcatc cgatcaggca cactcctcag     1920

tggaaagagc tgggttaatt ggtggagtga aattaaaagc catcccctca gatggcaact     1980

tcgccatgcg tgcgtctgcc ctgcaggaag ccctggagag agacaaagcg gctggcctga     2040

ttcctttctt tatggttgcc accctgggga ccacaacatg ctgctccttt gacaatctct     2100

tagaagtcgg tcctatctgc aacaaggaag acatatggct gcacgttgat gcagcctacg     2160

caggcagtgc attcatctgc cctgagttcc ggcaccttct gaatggagtg gagtttgcag     2220

attcattcaa ctttaatccc cacaaatggc tattggtgaa ttttgactgt tctgccatgt     2280

gggtgaaaaa gagaacagac ttaacgggag cctttagact ggaccccact tacctgaagc     2340

acagccatca ggattcaggg cttatcactg actaccggca ttggcagata ccactgggca     2400

gaagatttcg ctctttgaaa atgtggtttg tatttaggat gtatggagtc aaaggactgc     2460

aggcttatat ccgcaagcat gtccagctgt cccatgagtt tgagtcactg gtgcgccagg     2520

atccccgctt tgaaatctgt gtggaagtca ttctggggct tgtctgcttt cggctaaagg     2580

gttccaacaa agtgaatgaa gctcttctgc aaagaataaa cagtgccaaa aaaatccact     2640

tggttccatg tcacctcagg gacaagtttg tcctgcgctt tgccatctgt tctcgcacgg     2700

tggaatctgc ccatgtgcag cgggcctggg aacacatcaa agagctggcg gccgacgtgc     2760

tgcgagcaga gagggagtag gagtgaagcc aggacctgca gaagcttgcc tcgagcagcg     2820

ctgctcgaga gatctacggg tggcatccct gtgacccctc cccagtgcct ctcctggccc     2880

tggaagttgc cactccagtg cccaccagcc ttgtcctaat aaaattaagt tgcatcattt     2940

tgtctgacta ggtgtccttc tataatatta tggggtggag gggggtggta tggagcaagg     3000

ggcaagttgg gaagacaacc tgtagggcct gcggggtcta ttgggaacca agctggagtg     3060

cagtggcaca atcttggctc actgcaatct ccgcctcctg ggttcaagcg attctcctgc     3120

ctcagcctcc cgagttgttg ggattccagg catgcatgac caggctcagc taatttttgt     3180

ttttttggta gagacggggt ttcaccatat tggccaggct ggtctccaac tcctaatctc     3240

aggtgatcta cccaccttgg cctcccaaat tgctgggatt acaggcgtga accactgctc     3300

ccttccctgt ccttactaga tttaaatatg tcgtgcatcg atgctacgta gataagtagc     3360

atggcgggtt aatcattaac tacagaggaa cccctagtga tggagttggc cactccctct     3420

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     3480

gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcagg                    3526


<210> 3
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210> 4
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
gtcgacataa cgcgtata                                                     18


<210> 5
<211> 303
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctag tattagtcat cgctattacc      300

atg                                                                    303


<210> 6
<211> 204
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210> 7
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg       60

atccagcctc cgcggattcg aatcccggcc gggaacggtg cattggaacg cggattcccc      120

gtgccaagag tgac                                                        134


<210> 8
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
gtaagtaccg cctatagagt ctataggccc ac                                     32


<210> 9
<211> 347
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct       60

aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc accattctaa      120

agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat ataaatattt      180

ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag ctacaatcca      240

gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg agtccaagct      300

aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag                    347


<210> 10
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ctcctgggca acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga att              53


<210> 11
<211> 1440
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
atgaacgcaa gtgaattccg aaggagaggg aaggagatgg tggattacgt ggccaactac       60

atggaaggca ttgagggacg ccaggtctac cctgacgtgg agcccgggta cctgcggccg      120

ctgatccctg ccgctgcccc tcaggagcca gacacgtttg aggacatcat caacgacgtt      180

gagaagataa tcatgcctgg ggtgacgcac tggcacagcc cctacttctt cgcctacttc      240

cccactgcca gctcgtaccc ggccatgctt gcggacatgc tgtgcggggc cattggctgc      300

atcggcttct cctgggcggc aagcccagca tgcacagagc tggagactgt gatgatggac      360

tggctcggga agatgctgga actaccaaag gcatttttga atgagaaagc tggagaaggg      420

ggaggagtga tccagggaag tgccagtgaa gccaccctgg tggccctgct ggccgctcgg      480

accaaagtga tccatcggct gcaggcagcg tccccagagc tcacacaggc cgctatcatg      540

gagaagctgg tggcttactc atccgatcag gcacactcct cagtggaaag agctgggtta      600

attggtggag tgaaattaaa agccatcccc tcagatggca acttcgccat gcgtgcgtct      660

gccctgcagg aagccctgga gagagacaaa gcggctggcc tgattccttt ctttatggtt      720

gccaccctgg ggaccacaac atgctgctcc tttgacaatc tcttagaagt cggtcctatc      780

tgcaacaagg aagacatatg gctgcacgtt gatgcagcct acgcaggcag tgcattcatc      840

tgccctgagt tccggcacct tctgaatgga gtggagtttg cagattcatt caactttaat      900

ccccacaaat ggctattggt gaattttgac tgttctgcca tgtgggtgaa aaagagaaca      960

gacttaacgg gagcctttag actggacccc acttacctga agcacagcca tcaggattca     1020

gggcttatca ctgactaccg gcattggcag ataccactgg gcagaagatt tcgctctttg     1080

aaaatgtggt ttgtatttag gatgtatgga gtcaaaggac tgcaggctta tatccgcaag     1140

catgtccagc tgtcccatga gtttgagtca ctggtgcgcc aggatccccg ctttgaaatc     1200

tgtgtggaag tcattctggg gcttgtctgc tttcggctaa agggttccaa caaagtgaat     1260

gaagctcttc tgcaaagaat aaacagtgcc aaaaaaatcc acttggttcc atgtcacctc     1320

agggacaagt ttgtcctgcg ctttgccatc tgttctcgca cggtggaatc tgcccatgtg     1380

cagcgggcct gggaacacat caaagagctg gcggccgacg tgctgcgagc agagagggag     1440


<210> 12
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
gctgctcgag agatctac                                                     18


<210> 13
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtcctt         477


<210> 14
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


