                               SEQUENCE LISTING

<110> BIOGEN MA INC.
      NEURIMMUNE AG
 
<120> HUMAN-DERIVED ANTI-(POLY-GA) DIPEPTIDE REPEAT (DPR) ANTIBODY

<130> 13751-0309WO1

<140>
<141>

<150> 62/772,809
<151> 2018-11-29

<150> EP 18169888.7
<151> 2018-04-27

<160> 84    

<170> PatentIn version 3.5

<210> 1
<211> 372
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(372)
<223> /note="NI-308.5J10 variable heavy chain (VH) sequence"

<400> 1
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc act tac act gtc tta ggt ggc tcc gtc agt gat tac         96
Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr           
            20                  25                  30                    

tac tgg agc tgc atc cgg cag ccc gcc ggg aag gga ctg gag tgg att        144
Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg cga aca tat act aac ggg aag acc act tac act tac aac ccc tcc        192
Gly Arg Thr Tyr Thr Asn Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga ctc agt ttg tct ata gac acg tcc atg aac caa ttc        240
Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ttg acc tct gtg acg gcc gcg gac acg gcc gtc tat tac        288
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgc gcg aga tgg ggg gcg gtg act ggt gac tac tac tac ggt atg gac        336
Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp           
            100                 105                 110                   

gtc tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                        372
Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210> 2
<211> 124
<212> PRT
<213> Homo sapiens

<400> 2
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens

<400> 3
Asp Tyr Tyr Trp Ser 
1               5   


<210> 4
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4
Arg Thr Tyr Thr Asn Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Glu Ser 
        


<210> 5
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5
Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210> 6
<211> 336
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(336)
<223> /note="NI-308.5J10 variable light chain (VK) sequence"

<400> 6
gaa att gtg ctg act cag tct cca ctc tcc ctg tcc gtc acc cct gga         48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct cct cgg agc ctt cta cat act         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr           
            20                  25                  30                    

aat gga tat aca tat ttg gac tgg tac cta caa agg cca ggg cag tct        144
Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca caa ctc ctg atc ttt ttg gct tct aat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agc gga tca ggc aca aat ttt aca ctg aga atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Arg Ile           
65                  70                  75                  80            

agc gga gtg gag gct gac gat gtt gga gtt tat tac tgc atg caa ggt        288
Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

cta caa cct tcg tgg acg ttc ggc cag ggg acc aag gtg gaa atc aaa        336
Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210> 7
<211> 112
<212> PRT
<213> Homo sapiens

<400> 7
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 8
<211> 16
<212> PRT
<213> Homo sapiens

<400> 8
Arg Ser Pro Arg Ser Leu Leu His Thr Asn Gly Tyr Thr Tyr Leu Asp 
1               5                   10                  15      


<210> 9
<211> 7
<212> PRT
<213> Homo sapiens

<400> 9
Leu Ala Ser Asn Arg Ala Ser 
1               5           


<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Met Gln Gly Leu Gln Pro Ser Trp Thr 
1               5                   


<210> 11
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(372)
<223> /note="NI-308.5J10 variable heavy chain (VH) sequence - N54S
      mutation"

<400> 11
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc act tac act gtc tta ggt ggc tcc gtc agt gat tac         96
Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr           
            20                  25                  30                    

tac tgg agc tgc atc cgg cag ccc gcc ggg aag gga ctg gag tgg att        144
Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg cga aca tat act agc ggg aag acc act tac act tac aac ccc tcc        192
Gly Arg Thr Tyr Thr Ser Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga ctc agt ttg tct ata gac acg tcc atg aac caa ttc        240
Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ttg acc tct gtg acg gcc gcg gac acg gcc gtc tat tac        288
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgc gcg aga tgg ggg gcg gtg act ggt gac tac tac tac ggt atg gac        336
Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp           
            100                 105                 110                   

gtc tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                        372
Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           



<210> 12
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Ser Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 13
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NI-308.5J10 VH-CDR2 sequence - N54S mutation"

<400> 13
Arg Thr Tyr Thr Ser Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Glu Ser 
        


<210> 14
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(372)
<223> /note="NI-308.5J10 variable heavy chain (VH) sequence - N54T 
      Mutation"

<400> 14
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc act tac act gtc tta ggt ggc tcc gtc agt gat tac         96
Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr           
            20                  25                  30                    

tac tgg agc tgc atc cgg cag ccc gcc ggg aag gga ctg gag tgg att        144
Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg cga aca tat act acc ggg aag acc act tac act tac aac ccc tcc        192
Gly Arg Thr Tyr Thr Thr Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga ctc agt ttg tct ata gac acg tcc atg aac caa ttc        240
Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ttg acc tct gtg acg gcc gcg gac acg gcc gtc tat tac        288
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgc gcg aga tgg ggg gcg gtg act ggt gac tac tac tac ggt atg gac        336
Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp           
            100                 105                 110                   

gtc tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                        372
Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210> 15
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Thr Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 16
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NI-308.5J10 VH-CDR2 sequence  - N54T mutation"

<400> 16
Arg Thr Tyr Thr Thr Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Glu Ser 
        


<210> 17
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(372)
<223> /note="NI-308.5J10 variable heavy chain (VH) sequence - G55S 
      Mutation"

<400> 17
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc act tac act gtc tta ggt ggc tcc gtc agt gat tac         96
Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr           
            20                  25                  30                    

tac tgg agc tgc atc cgg cag ccc gcc ggg aag gga ctg gag tgg att        144
Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg cga aca tat act aac agc aag acc act tac act tac aac ccc tcc        192
Gly Arg Thr Tyr Thr Asn Ser Lys Thr Thr Tyr Thr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga ctc agt ttg tct ata gac acg tcc atg aac caa ttc        240
Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ttg acc tct gtg acg gcc gcg gac acg gcc gtc tat tac        288
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgc gcg aga tgg ggg gcg gtg act ggt gac tac tac tac ggt atg gac        336
Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp           
            100                 105                 110                   

gtc tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                        372
Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210> 18
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Ser Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 19
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NI-308.5J10 VH-CDR2 sequence - G55S mutation"

<400> 19
Arg Thr Tyr Thr Asn Ser Lys Thr Thr Tyr Thr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Glu Ser 
        


<210> 20
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(372)
<223> /note="NI-308.5J10 variable heavy chain (VH) sequence - G55T 
      Mutation"

<400> 20
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc act tac act gtc tta ggt ggc tcc gtc agt gat tac         96
Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr           
            20                  25                  30                    

tac tgg agc tgc atc cgg cag ccc gcc ggg aag gga ctg gag tgg att        144
Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg cga aca tat act aac acc aag acc act tac act tac aac ccc tcc        192
Gly Arg Thr Tyr Thr Asn Thr Lys Thr Thr Tyr Thr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga ctc agt ttg tct ata gac acg tcc atg aac caa ttc        240
Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ttg acc tct gtg acg gcc gcg gac acg gcc gtc tat tac        288
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgc gcg aga tgg ggg gcg gtg act ggt gac tac tac tac ggt atg gac        336
Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp           
            100                 105                 110                   

gtc tgg ggc cca ggc acc ctg gtc acc gtc tcc tcg                        372
Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           



<210> 21
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Thr Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 22
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NI-308.5J10 VH-CDR2 sequence  - G55T mutation"

<400> 22
Arg Thr Tyr Thr Asn Thr Lys Thr Thr Tyr Thr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Glu Ser 
        


<210> 23
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(336)
<223> /note="NI-308.5J10 variable light chain (VK) sequence - N75D 
      Mutation"

<400> 23
gaa att gtg ctg act cag tct cca ctc tcc ctg tcc gtc acc cct gga         48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct cct cgg agc ctt cta cat act         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr           
            20                  25                  30                    

aat gga tat aca tat ttg gac tgg tac cta caa agg cca ggg cag tct        144
Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca caa ctc ctg atc ttt ttg gct tct aat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agc gga tca ggc aca gac ttt aca ctg aga atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile           
65                  70                  75                  80            

agc gga gtg gag gct gac gat gtt gga gtt tat tac tgc atg caa ggt        288
Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

cta caa cct tcg tgg acg ttc ggc cag ggg acc aag gtg gaa atc aaa        336
Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210> 24
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 25
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10 variable light chain (VK) plasmid 
     (SDD 152)"

<400> 25
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 26
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-hIgG1 variable heavy chain (VH) plasmid 
     (SDD 151)"

<400> 26
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210> 27
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10 variable light chain (VK) plasmid (SDD 177) 
      - N75D mutation"

<400> 27
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Pro Arg Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 28
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-hIgG1 variable heavy chain (VH) plasmid 
      (SDD 173) - N54S mutation"
 
<400> 28
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Ser Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210> 29
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-hIgG1 variable heavy chain (VH) plasmid 
      (SDD 174) - N54T mutation"
 
<400> 29
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Thr Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210> 30
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-hIgG1 variable heavy chain (VH) plasmid 
      (SDD 175) - G55S mutation"

<400> 30
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Ser Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210> 31
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-hIgG1 variable heavy chain (VH) plasmid 
      (SDD 176) - G55T mutation"

<400> 31
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Thr Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210> 32
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-Fab-6His variable heavy chain (VH) plasmid
      (SDD 178)"

<400> 32
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210> 33
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note=" NI-308.5J10-Fab-6His variable heavy chain (VH) plasmid 
      (SDD 179) - N54S mutation"

<400> 33
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Ser Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210> 34
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-Fab-6His variable heavy chain (VH) plasmid 
      (SDD 180) - N54T mutation"

<400> 34
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Thr Gly Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210> 35
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-Fab-6His variable heavy chain (VH) plasmid 
      (SDD 181) - G55S mutation"

<400> 35
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Ser Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210> 36
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NI-308.5J10-Fab-6His variable heavy chain (VH) plasmid 
      (SDD 182) - G55T mutation"

<400> 36
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Tyr Thr Val Leu Gly Gly Ser Val Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Cys Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Thr Tyr Thr Asn Thr Lys Thr Thr Tyr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Ser Leu Ser Ile Asp Thr Ser Met Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Val Thr Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210> 37
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Ile Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Tyr Ser Leu Thr Ala Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210> 38
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Thr Ala Asp Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210> 39
<211> 329
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210> 40
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Thr Ala Asp Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 41
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asn Ile Asp Lys Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Ser Phe Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210> 42
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 43
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 44
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 45
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gly Phe Thr Phe Ser Asn His Ala Met His 
1               5                   10  


<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Val Ile Ser Tyr Asp Gly Glu Asn Thr Tyr Tyr Ala Asp Ser Ile Glu 
1               5                   10                  15      


Gly 
    


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gly Gly Arg Arg Gly His Phe Thr Ser Tyr Tyr Leu Asp Tyr 
1               5                   10                  


<210> 48
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Arg Ala Ser Gln Asn Ile Asp Lys Tyr Leu Asn 
1               5                   10      


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Ala Ala Ser Ser Leu His Ser 
1               5           


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gln Gln Ser Tyr Ser Ser Phe Arg Thr 
1               5                   


<210> 51
<211> 1416
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 51
atgggttgga gcctcatctt gctgtttctt gtcgctgttg ctacgcgtgt cctgtcgcag       60

gtgcagctgg tggagtctgg gggaggcgta gtccagcctg ggaggtccct gagactgtcc      120

tgtgcagcct ctggattcac cttcagtaat catgctatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tcatatgatg gcgagaacac atattatgca      240

gactccattg agggccgatt caccatttcc agagacaatt tcaagaacac actctttcta      300

caaatgtaca gcctgacagc tgatgacacg gctatgtact tctgtgcgag agggggccgt      360

cgggggcact tcacctcata ctaccttgac tactggggcc agggaaccct ggtcaccgtc      420

tcctcggcta gtaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acccgtgacg      540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa gactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtttccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgttgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaaa aaagcctctc cctgtctccc ggttga                               1416


<210> 52
<211> 1359
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
caggtgcagc tggtggagtc tgggggaggc gtagtccagc ctgggaggtc cctgagactg       60

tcctgtgcag cctctggatt caccttcagt aatcatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggcgagaa cacatattat      180

gcagactcca ttgagggccg attcaccatt tccagagaca atttcaagaa cacactcttt      240

ctacaaatgt acagcctgac agctgatgac acggctatgt acttctgtgc gagagggggc      300

cgtcgggggc acttcacctc atactacctt gactactggg gccagggaac cctggtcacc      360

gtctcctcgg ctagtaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacccgtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caagactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtttcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgt tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc aaaaaagcct ctccctgtct cccggttga                            1359


<210> 53
<211> 990
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 53
gctagtacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaagactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtttc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ttggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

caaaaaagcc tctccctgtc tcccggttga                                       990


<210> 54
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
caggtgcagc tggtggagtc tgggggaggc gtagtccagc ctgggaggtc cctgagactg       60

tcctgtgcag cctctggatt caccttcagt aatcatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggcgagaa cacatattat      180

gcagactcca ttgagggccg attcaccatt tccagagaca atttcaagaa cacactcttt      240

ctacaaatgt acagcctgac agctgatgac acggctatgt acttctgtgc gagagggggc      300

cgtcgggggc acttcacctc atactacctt gactactggg gccagggaac cctggtcacc      360

gtctcctcg                                                              369


<210> 55
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 55
atggacatgc gggtgcccgc ccagctgctg ggcctgctgc tgctgtggtt ccccggctct       60

agatgcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccgggc aagccagaac atagacaagt acttaaattg gtatcagcag      180

ataccgggga aagcccctaa gctcctgatc tatgctgcat cgagtttgca cagtggggtc      240

ccatcaaggt tcagtggcag tggatctggg acagatttct ctctcaccat cagcagtctg      300

caacctgaag attttgcaat ttactactgt caacagagtt acagttcctt ccggacgttc      360

ggccaaggga ccaagctgga gatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gttcgcccgt cacaaagagc ttcaacaggg gagagtgttg a               711


<210> 56
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagcca gaacatagac aagtacttaa attggtatca gcagataccg      120

gggaaagccc ctaagctcct gatctatgct gcatcgagtt tgcacagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttctctctca ccatcagcag tctgcaacct      240

gaagattttg caatttacta ctgtcaacag agttacagtt ccttccggac gttcggccaa      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagttcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210> 57
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 57
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagttcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttga                                             324


<210> 58
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagcca gaacatagac aagtacttaa attggtatca gcagataccg      120

gggaaagccc ctaagctcct gatctatgct gcatcgagtt tgcacagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttctctctca ccatcagcag tctgcaacct      240

gaagattttg caatttacta ctgtcaacag agttacagtt ccttccggac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321


<210> 59
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser 
            


<210> 60
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys 
            20          


<210> 61
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)15"

<400> 61
Cys His His His His His His Gly Ala Gly Ala Gly Ala Gly Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Gly Ala Gly Ala 
        35          


<210> 62
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GP)15"

<400> 62
Cys Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly 
1               5                   10                  15      


Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
            20                  25                  30      


<210> 63
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GR)15"

<400> 63
Cys Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
1               5                   10                  15      


Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            20                  25                  30      


<210> 64
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (PA)15"

<400> 64
Cys Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
            20                  25                  30      


<210> 65
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (PR)15"

<400> 65
Cys Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg 
            20                  25                  30      


<210> 66
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein peptide GA"

<400> 66
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            20                  25                  30  


<210> 67
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein peptide GP"

<400> 67
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
1               5                   10                  15      


Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
            20                  25                  30  


<210> 68
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein peptide GR"

<400> 68
Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
1               5                   10                  15      


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            20                  25                  30  


<210> 69
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein peptide PA"

<400> 69
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
            20                  25                  30  


<210> 70
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein peptide PR"

<400> 70
Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg 
            20                  25                  30  


<210> 71
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)20"

<400> 71
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            20                  25                  30          


Gly Ala Gly Ala Gly Ala Gly Ala His His His His His His 
        35                  40                  45      


<210> 72
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)10"

<400> 72
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala His His His His His His 
            20                  25      


<210> 73
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)6"

<400> 73
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala His His His His 
1               5                   10                  15      


His His 
        


<210> 74
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)5"

<400> 74
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala His His His His His His 
1               5                   10                  15      


<210> 75
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)4"

<400> 75
Gly Ala Gly Ala Gly Ala Gly Ala His His His His His His 
1               5                   10                  


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)3"

<400> 76
Gly Ala Gly Ala Gly Ala His His His His His His 
1               5                   10          


<210> 77
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      dipeptide repeat protein (GA)2"

<400> 77
Gly Ala Gly Ala His His His His His His 
1               5                   10  


<210> 78
<211> 10
<212> PRT
<213> Homo sapiens

<400> 78
Gly Gly Ser Val Ser Asp Tyr Tyr Trp Ser 
1               5                   10  


<210> 79
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala 
            20  


<210> 80
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10          


<210> 81
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


<210> 82
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            20                  25                  30          


Gly Ala Gly Ala Gly Ala Gly Ala 
        35                  40  


<210> 83
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(30)
<223> /note="This sequence may encompass 6-15 "Gly Ala" repeating
      units"

<400> 83
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            20                  25                  30  


<210> 84
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 84
His His His His His His 
1               5       


