                         SEQUENCE LISTING

<110>  Rawlings, David J.
       Khan, Iram F.
       Honaker, Yuchi Chiang
       Singh, Swati
       Sommer, Karen
       Scharenberg, Andrew M.
 
<120>  Expression of FOXP3 in Edited CD34+ Cells
<130>  SCRI188WO

<140>  62/663,545
<141>  2018-04-27

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T1 Guide sequence

<400>  1
ttccagggcc gagatcttcg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T3 Guide sequence

<400>  2
cgcctcgaag atctcggccc                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T4 Guide sequence

<400>  3
tcgaagatct cggccctgga                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T7 Guide sequence

<400>  4
ggccctggaa ggttccccct                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T9 Guide sequence

<400>  5
tccagctggg cgaggctcct                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T18 Guide sequence

<400>  6
tcagacctgc tgggggcccg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R1 Guide sequence

<400>  7
gagccccgcc tcgaagatct                                                   20


<210>  8
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T1 PAM sequence

<400>  8
agg                                                                      3


<210>  9
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T3 PAM sequence

<400>  9
tgg                                                                      3


<210>  10
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T4 PAM sequence

<400>  10
agg                                                                      3


<210>  11
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T7 PAM sequence

<400>  11
ggg                                                                      3


<210>  12
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T9 PAM sequence

<400>  12
ggg                                                                      3


<210>  13
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  T18 PAM sequence

<400>  13
ggg                                                                      3


<210>  14
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R1 PAM sequence

<400>  14
cgg                                                                      3


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P1 Guide sequence

<400>  15
attcccaggg ccggttaatg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P3 Guide sequence

<400>  16
gtcccctcca ccccacagtg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P4 Guide sequence

<400>  17
accccacagt ggggccacta                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N1 Guide sequence

<400>  18
cctctaaggt ttgcttacga                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N2 Guide sequence

<400>  19
tataaggtgg tcccagctcg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N3 Guide sequence

<400>  20
ccatcgtaag caaaccttag                                                   20


<210>  21
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P1 PAM sequence

<400>  21
tgg                                                                      3


<210>  22
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P3 PAM sequence

<400>  22
ggg                                                                      3


<210>  23
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P4 PAM sequence

<400>  23
ggg                                                                      3


<210>  24
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N1 PAM sequence

<400>  24
tgg                                                                      3


<210>  25
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N2 PAM sequence

<400>  25
ggg                                                                      3


<210>  26
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  N3 PAM sequence

<400>  26
agg                                                                      3


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T20 Guide sequence

<400>  27
gactcctggg gatgggccaa                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T22 Guide sequence

<400>  28
ttggcccttg gcccatcccc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T23 Guide sequence

<400>  29
ccagcttggc aagactcctg                                                   20


<210>  30
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T20 PAM sequence

<400>  30
ggg                                                                      3


<210>  31
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T22 PAM sequence

<400>  31
agg                                                                      3


<210>  32
<211>  3
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  m T23 PAM sequence

<400>  32
ggg                                                                      3


<210>  33
<211>  6679
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3008 pAAV_FoxP3_0_6kb_MND_GFP_WPRE3_pA

<400>  33
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc      720

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc      780

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      840

taatgcagct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      900

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      960

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc     1020

ggccgctcag aatctaccca cttctcgcct tctccactgc caccagccca ttctgtgcca     1080

gcatcatcac ttgccaggac tgttacaata gcctcctcac tagccccact cacagcagcc     1140

agatgaatct tttgagtcca tgcctagtca ctggggcaaa ataggactcc gaggagaaag     1200

tccgagacca gctccggcaa gatgagcaaa cacagcctgt gcagggtgca gggagggcta     1260

gaggcctgag gcttgaaaca gctctcaagt ggagggggaa acaaccattg ccctcataga     1320

ggacacatcc acaccagggc tgtgctagcg tgggcaggca agccaggtgc tggacctctg     1380

cacgtggggc atgtgtgggt atgtacatgt acctgtgttc ttggtgtgtg tgtgtgtgtg     1440

tgtgtgtgtg tgtgtctaga gctggggtgc aactatgggg cccctcggga catgtcccag     1500

ccaatgcctg ctttgaccag aggagtgtcc acgtggctca ggtggtcgag tatctcatac     1560

cgccctagca cacgtgtgac tcctttcccc tattgtctac gcagcctgcc cttggacaag     1620

gacccgacgc gtaggaacag agaaacagga gaatatgggc caaacaggat atctgtggta     1680

agcagttcct gccccggctc agggccaaga acagttggaa cagcagaata tgggccaaac     1740

aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggtccccag     1800

atgcggtccc gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag     1860

gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc tcgcttctgt     1920

tcgcgcgctt ctgctccccg agctctatat aagcagagct cgtttagtga accgtcagat     1980

cgcctggaga cgccatccac gctgttttga cttccataga aggatctcga ggccaccatg     2040

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     2100

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     2160

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     2220

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag     2280

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     2340

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     2400

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     2460

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     2520

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     2580

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     2640

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     2700

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaaaag     2760

cttgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     2820

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     2880

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttagttct tgccacggcg     2940

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     3000

aattccgtgg gtcgactgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     3060

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     3120

tcagggggag atgtgggagg ttttttaaag cactagtgtg aggccctggg cccaggatgg     3180

ggcaggcagg gtggggtacc tggacctaca ggtgccgacc tttactgtgg cactgggcgg     3240

gaggggggct ggctggggca caggaagtgg tttctgggtc ccaggcaagt ctgtgactta     3300

tgcagatgtt gcagggccaa gaaaatcccc acctgccagg cctcagagat tggaggctct     3360

ccccgacctc ccaatccctg tctcaggaga ggaggaggcc gtattgtagt cccatgagca     3420

tagctatgtg tccccatccc catgtgacaa gagaagagga ctggggccaa gtaggtgagg     3480

tgacagggct gaggccagct ctgcaactta ttagctgttt gatctttaaa aagttactcg     3540

atctccatga gcctcagttt ccatacgtgt aaaaggggga tgatcatagc atctaccatg     3600

tgggcttgca gtgcagagta tttgaattag acacagaaca gtgaggatca ggatggcctc     3660

tcacccacct gcctttctgc ccagctgccc acactgcccc tagtcatggt ggcaccctcc     3720

ggggcacggc tgggcccctt gccccactta caggcaccgc ggcgctacgt agataagtag     3780

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     3840

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     3900

gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg     3960

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgat tccgttgcaa     4020

tggctggcgg taatattgtt ctggatatta ccagcaaggc cgatagtttg agttcttcta     4080

ctcaggcaag tgatgttatt actaatcaaa gaagtattgc gacaacggtt aatttgcgtg     4140

atggacagac tcttttactc ggtggcctca ctgattataa aaacacttct caggattctg     4200

gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct gtttagctcc cgctctgatt     4260

ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac catagtacgc gccctgtagc     4320

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     4380

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     4440

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     4500

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag     4560

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     4620

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     4680

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac     4740

aaaatattaa cgtttacaat ttaaatattt gcttatacaa tcttcctgtt tttggggctt     4800

ttctgattat caaccggggt acatatgatt gacatgctag ttttacgatt accgttcatc     4860

gattctcttg tttgctccag actctcaggc aatgacctga tagcctttgt agagacctct     4920

caaaaatagc taccctctcc ggcatgaatt tatcagctag aacggttgaa tatcatattg     4980

atggtgattt gactgtctcc ggcctttctc acccgtttga atctttacct acacattact     5040

caggcattgc atttaaaata tatgagggtt ctaaaaattt ttatccttgc gttgaaataa     5100

aggcttctcc cgcaaaagta ttacagggtc ataatgtttt tggtacaacc gatttagctt     5160

tatgctctga ggctttattg cttaattttg ctaattcttt gccttgcctg tatgatttat     5220

tggatgttgg aatcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     5280

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     5340

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     5400

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     5460

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     5520

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     5580

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5640

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5700

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5760

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5820

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     5880

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     5940

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6000

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6060

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6120

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6180

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     6240

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6300

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6360

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6420

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6480

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6540

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6600

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6660

ccactgagcg tcagacccc                                                  6679


<210>  34
<211>  6844
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3037 pAAV_FoxP3_0_6kb_FoxP3cDNA_WPRE3_pA

<400>  34
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc      720

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc      780

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      840

taatgcagct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      900

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      960

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc     1020

ggccgctcag aatctaccca cttctcgcct tctccactgc caccagccca ttctgtgcca     1080

gcatcatcac ttgccaggac tgttacaata gcctcctcac tagccccact cacagcagcc     1140

agatgaatct tttgagtcca tgcctagtca ctggggcaaa ataggactcc gaggagaaag     1200

tccgagacca gctccggcaa gatgagcaaa cacagcctgt gcagggtgca gggagggcta     1260

gaggcctgag gcttgaaaca gctctcaagt ggagggggaa acaaccattg ccctcataga     1320

ggacacatcc acaccagggc tgtgctagcg tgggcaggca agccaggtgc tggacctctg     1380

cacgtggggc atgtgtgggt atgtacatgt acctgtgttc ttggtgtgtg tgtgtgtgtg     1440

tgtgtgtgtg tgtgtctaga gctggggtgc aactatgggg cccctcggga catgtcccag     1500

ccaatgcctg ctttgaccag aggagtgtcc acgtggctca ggtggtcgag tatctcatac     1560

cgccctagca cacgtgtgac tcctttcccc tattgtctac gcagcctgcc cttggacaag     1620

gacccgatgc ctaatcctcg gcctggaaag cctagcgctc cttctcttgc tctgggacct     1680

tctcctggcg cctctccatc ttggagagcc gctcctaaag ccagcgatct gctgggagct     1740

agaggacctg gcggcacatt tcagggcaga gatcttagag gcggagccca cgctagctcc     1800

tccagcctta atcctatgcc tcctagccag ctccagctgc ctacactgcc tctggttatg     1860

gtggctccta gcggagctag actgggccct ctgcctcatc tgcaagctct gctgcaggac     1920

agaccccact tcatgcacca gctgagcacc gtggatgccc acgcaagaac acctgtgctg     1980

caggttcacc ctctggaatc cccagccatg atcagcctga cacctccaac aacagccacc     2040

ggcgtgttca gcctgaaagc cagacctgga ctgcctcctg gcatcaatgt ggccagcctg     2100

gaatgggtgt ccagagaacc tgctctgctg tgcacattcc ccaatccaag cgctcccaga     2160

aaggacagca cactgtctgc cgtgcctcag agcagctatc ccctgcttgc taacggcgtg     2220

tgcaagtggc ctggatgcga gaaggtgttc gaggaacccg aggacttcct gaagcactgc     2280

caggccgatc atctgctgga cgagaaaggc agagcccagt gtctgctcca gcgcgagatg     2340

gtgcagtctc tggaacagca gctggtcctg gaaaaagaaa agctgagcgc catgcaggcc     2400

cacctggccg gaaaaatggc cctgacaaag gccagcagcg tggcctcttc tgataagggc     2460

agctgctgca ttgtggccgc tggatctcag ggacctgtgg ttcctgcttg gagcggacct     2520

agagaggccc ctgattctct gtttgccgtg cggagacacc tgtggggctc tcacggcaac     2580

tctactttcc ccgagttcct gcacaacatg gactacttca agttccacaa catgcggcct     2640

ccattcacct acgccacact gatcagatgg gccattctgg aagcccctga gaagcagaga     2700

accctgaacg agatctacca ctggtttacc cggatgttcg ccttcttccg gaatcaccct     2760

gccacctgga agaacgccat ccggcacaat ctgagcctgc acaagtgctt cgtgcgcgtg     2820

gaatctgaga aaggcgccgt gtggacagtg gacgagctgg aattcagaaa gaagagaagc     2880

cagcggccta gccggtgcag caatcctaca cctggacctt gaaagcttga taatcaacct     2940

ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg     3000

ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc     3060

attttctcct ccttgtataa atcctggtta gttcttgcca cggcggaact catcgccgcc     3120

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtgggtcga     3180

ctgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa     3240

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggagatgtg     3300

ggaggttttt taaagcacta gtgtgaggcc ctgggcccag gatggggcag gcagggtggg     3360

gtacctggac ctacaggtgc cgacctttac tgtggcactg ggcgggaggg gggctggctg     3420

gggcacagga agtggtttct gggtcccagg caagtctgtg acttatgcag atgttgcagg     3480

gccaagaaaa tccccacctg ccaggcctca gagattggag gctctccccg acctcccaat     3540

ccctgtctca ggagaggagg aggccgtatt gtagtcccat gagcatagct atgtgtcccc     3600

atccccatgt gacaagagaa gaggactggg gccaagtagg tgaggtgaca gggctgaggc     3660

cagctctgca acttattagc tgtttgatct ttaaaaagtt actcgatctc catgagcctc     3720

agtttccata cgtgtaaaag ggggatgatc atagcatcta ccatgtgggc ttgcagtgca     3780

gagtatttga attagacaca gaacagtgag gatcaggatg gcctctcacc cacctgcctt     3840

tctgcccagc tgcccacact gcccctagtc atggtggcac cctccggggc acggctgggc     3900

cccttgcccc acttacaggc accgcggcgc tacgtagata agtagcatgg cgggttaatc     3960

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4020

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4080

gtgagcgagc gagcgcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     4140

ccaacagttg cgcagcctga atggcgaatg gcgattccgt tgcaatggct ggcggtaata     4200

ttgttctgga tattaccagc aaggccgata gtttgagttc ttctactcag gcaagtgatg     4260

ttattactaa tcaaagaagt attgcgacaa cggttaattt gcgtgatgga cagactcttt     4320

tactcggtgg cctcactgat tataaaaaca cttctcagga ttctggcgta ccgttcctgt     4380

ctaaaatccc tttaatcggc ctcctgttta gctcccgctc tgattctaac gaggaaagca     4440

cgttatacgt gctcgtcaaa gcaaccatag tacgcgccct gtagcggcgc attaagcgcg     4500

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     4560

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     4620

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     4680

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     4740

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     4800

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     4860

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgttt     4920

acaatttaaa tatttgctta tacaatcttc ctgtttttgg ggcttttctg attatcaacc     4980

ggggtacata tgattgacat gctagtttta cgattaccgt tcatcgattc tcttgtttgc     5040

tccagactct caggcaatga cctgatagcc tttgtagaga cctctcaaaa atagctaccc     5100

tctccggcat gaatttatca gctagaacgg ttgaatatca tattgatggt gatttgactg     5160

tctccggcct ttctcacccg tttgaatctt tacctacaca ttactcaggc attgcattta     5220

aaatatatga gggttctaaa aatttttatc cttgcgttga aataaaggct tctcccgcaa     5280

aagtattaca gggtcataat gtttttggta caaccgattt agctttatgc tctgaggctt     5340

tattgcttaa ttttgctaat tctttgcctt gcctgtatga tttattggat gttggaatcg     5400

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatggtgcac     5460

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc     5520

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac     5580

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg     5640

aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta     5700

gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     5760

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     5820

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     5880

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     5940

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     6000

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     6060

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     6120

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     6180

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     6240

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     6300

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     6360

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     6420

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     6480

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     6540

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     6600

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     6660

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     6720

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     6780

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     6840

cccc                                                                  6844


<210>  35
<211>  7048
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3088 pAAV_FOXP3_08_MND_GFP 08_for T3

<400>  35
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc      720

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc      780

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      840

taatgcagct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      900

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      960

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc     1020

ggccgccttg cccactacat ccaagctgct agcactgctc ctgatccagc ttcagattaa     1080

gtctcagaat ctacccactt ctcgccttct ccactgccac cagcccattc tgtgccagca     1140

tcatcacttg ccaggactgt tacaatagcc tcctcactag ccccactcac agcagccaga     1200

tgaatctttt gagtccatgc ctagtcactg gggcaaaata ggactccgag gagaaagtcc     1260

gagaccagct ccggcaagat gagcaaacac agcctgtgca gggtgcaggg agggctagag     1320

gcctgaggct tgaaacagct ctcaagtgga gggggaaaca accattgccc tcatagagga     1380

cacatccaca ccagggctgt gctagcgtgg gcaggcaagc caggtgctgg acctctgcac     1440

gtggggcatg tgtgggtatg tacatgtacc tgtgttcttg gtgtgtgtgt gtgtgtgtgt     1500

gtgtgtgtgt gtctagagct ggggtgcaac tatggggccc ctcgggacat gtcccagcca     1560

atgcctgctt tgaccagagg agtgtccacg tggctcaggt ggtcgagtat ctcataccgc     1620

cctagcacac gtgtgactcc tttcccctat tgtctacgca gcctgccctt ggacaaggac     1680

ccgatgccca accccaggcc tggcaagccc tcggcccctt ccttggccct tggcccatcc     1740

ccaggagcct cgcccagctg gagggctgca cccaaagcct cagacctgct gggggcccgg     1800

ggcccagggg gaaccttcca acgcgtagga acagagaaac aggagaatat gggccaaaca     1860

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagtt ggaacagcag     1920

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     1980

cagatggtcc ccagatgcgg tcccgccctc agcagtttct agagaaccat cagatgtttc     2040

cagggtgccc caaggacctg aaatgaccct gtgccttatt tgaactaacc aatcagttcg     2100

cttctcgctt ctgttcgcgc gcttctgctc cccgagctct atataagcag agctcgttta     2160

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacttcca tagaaggatc     2220

tcgaggccac catggtgagc aagggcgagg agctgttcac cggggtggtg cccatcctgg     2280

tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag ggcgagggcg     2340

atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag ctgcccgtgc     2400

cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc cgctaccccg     2460

accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc     2520

gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg aagttcgagg     2580

gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag gacggcaaca     2640

tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc atggccgaca     2700

agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag gacggcagcg     2760

tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc     2820

ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac gagaagcgcg     2880

atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc atggacgagc     2940

tgtacaagta aaagcttgat aatcaacctc tggattacaa aatttgtgaa agattgactg     3000

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt     3060

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttag     3120

ttcttgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc     3180

tgttgggcac tgacaattcc gtgggtcgac tgctttattt gtgaaatttg tgatgctatt     3240

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat     3300

tttatgtttc aggttcaggg ggagatgtgg gaggtttttt aaagcactag tcgagatctt     3360

cgaggcgggg cccatgcctc ctcttcttcc ttgaacccca tgccaccatc gcagctgcag     3420

gtgaggccct gggcccagga tggggcaggc agggtggggt acctggacct acaggtgccg     3480

acctttactg tggcactggg cgggaggggg gctggctggg gcacaggaag tggtttctgg     3540

gtcccaggca agtctgtgac ttatgcagat gttgcagggc caagaaaatc cccacctgcc     3600

aggcctcaga gattggaggc tctccccgac ctcccaatcc ctgtctcagg agaggaggag     3660

gccgtattgt agtcccatga gcatagctat gtgtccccat ccccatgtga caagagaaga     3720

ggactggggc caagtaggtg aggtgacagg gctgaggcca gctctgcaac ttattagctg     3780

tttgatcttt aaaaagttac tcgatctcca tgagcctcag tttccatacg tgtaaaaggg     3840

ggatgatcat agcatctacc atgtgggctt gcagtgcaga gtatttgaat tagacacaga     3900

acagtgagga tcaggatggc ctctcaccca cctgcctttc tgcccagctg cccacactgc     3960

ccctagtcat ggtggcaccc tccggggcac ggctgggccc cttgccccac ttacaggcac     4020

tcctccagga caggccacat ttcatgcacc aggtatggac ggtgaatggg cagggaggag     4080

ggagcaggtg ggagaactgt ggggaggggc cccgagtcag gctgaaccgg atcctacgta     4140

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4200

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4260

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gccagctggc gtaatagcga     4320

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgatt     4380

ccgttgcaat ggctggcggt aatattgttc tggatattac cagcaaggcc gatagtttga     4440

gttcttctac tcaggcaagt gatgttatta ctaatcaaag aagtattgcg acaacggtta     4500

atttgcgtga tggacagact cttttactcg gtggcctcac tgattataaa aacacttctc     4560

aggattctgg cgtaccgttc ctgtctaaaa tccctttaat cggcctcctg tttagctccc     4620

gctctgattc taacgaggaa agcacgttat acgtgctcgt caaagcaacc atagtacgcg     4680

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4740

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4800

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     4860

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4920

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4980

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     5040

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5100

aattttaaca aaatattaac gtttacaatt taaatatttg cttatacaat cttcctgttt     5160

ttggggcttt tctgattatc aaccggggta catatgattg acatgctagt tttacgatta     5220

ccgttcatcg attctcttgt ttgctccaga ctctcaggca atgacctgat agcctttgta     5280

gagacctctc aaaaatagct accctctccg gcatgaattt atcagctaga acggttgaat     5340

atcatattga tggtgatttg actgtctccg gcctttctca cccgtttgaa tctttaccta     5400

cacattactc aggcattgca tttaaaatat atgagggttc taaaaatttt tatccttgcg     5460

ttgaaataaa ggcttctccc gcaaaagtat tacagggtca taatgttttt ggtacaaccg     5520

atttagcttt atgctctgag gctttattgc ttaattttgc taattctttg ccttgcctgt     5580

atgatttatt ggatgttgga atcgcctgat gcggtatttt ctccttacgc atctgtgcgg     5640

tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag     5700

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     5760

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     5820

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     5880

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     5940

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     6000

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     6060

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     6120

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     6180

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     6240

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     6300

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     6360

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     6420

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     6480

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     6540

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     6600

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     6660

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     6720

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     6780

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     6840

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     6900

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     6960

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     7020

gttttcgttc cactgagcgt cagacccc                                        7048


<210>  36
<211>  7056
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3089 pAAV_FOXP3_08_MND_GFP08_for T9

<400>  36
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc      720

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc      780

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      840

taatgcagct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      900

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      960

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc     1020

ggccgcatct caggtaatgt cagctcggtc cttccagctg ctcaagctaa aacccatgtc     1080

actttgactc tccctcttgc ccactacatc caagctgcta gcactgctcc tgatccagct     1140

tcagattaag tctcagaatc tacccacttc tcgccttctc cactgccacc agcccattct     1200

gtgccagcat catcacttgc caggactgtt acaatagcct cctcactagc cccactcaca     1260

gcagccagat gaatcttttg agtccatgcc tagtcactgg ggcaaaatag gactccgagg     1320

agaaagtccg agaccagctc cggcaagatg agcaaacaca gcctgtgcag ggtgcaggga     1380

gggctagagg cctgaggctt gaaacagctc tcaagtggag ggggaaacaa ccattgccct     1440

catagaggac acatccacac cagggctgtg ctagcgtggg caggcaagcc aggtgctgga     1500

cctctgcacg tggggcatgt gtgggtatgt acatgtacct gtgttcttgg tgtgtgtgtg     1560

tgtgtgtgtg tgtgtgtgtg tctagagctg gggtgcaact atggggcccc tcgggacatg     1620

tcccagccaa tgcctgcttt gaccagagga gtgtccacgt ggctcaggtg gtcgagtatc     1680

tcataccgcc ctagcacacg tgtgactcct ttcccctatt gtctacgcag cctgcccttg     1740

gacaaggacc cgatgcccaa ccccaggcct ggcaagccct cggccccttc cttggccctt     1800

ggcccatccc cacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg     1860

tggtaagcag ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc     1920

caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc     1980

cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc     2040

ccaaggacct gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct     2100

tctgttcgcg cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt     2160

cagatcgcct ggagacgcca tccacgctgt tttgacttcc atagaaggat ctcgaggcca     2220

ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg     2280

acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct     2340

acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca     2400

ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga     2460

agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct     2520

tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc     2580

tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc     2640

acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga     2700

acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg     2760

ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc     2820

actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg     2880

tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt     2940

aaaagcttga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     3000

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     3060

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggtta gttcttgcca     3120

cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca     3180

ctgacaattc cgtgggtcga ctgctttatt tgtgaaattt gtgatgctat tgctttattt     3240

gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt     3300

caggttcagg gggagatgtg ggaggttttt taaagcacta gtgcctcgcc cagctggagg     3360

gctgcaccca aagcctcaga cctgctgggg gcccggggcc cagggggaac cttccagggc     3420

cgagatcttc gaggcggggc ccatgcctcc tcttcttcct tgaaccccat gccaccatcg     3480

cagctgcagg tgaggccctg ggcccaggat ggggcaggca gggtggggta cctggaccta     3540

caggtgccga cctttactgt ggcactgggc gggagggggg ctggctgggg cacaggaagt     3600

ggtttctggg tcccaggcaa gtctgtgact tatgcagatg ttgcagggcc aagaaaatcc     3660

ccacctgcca ggcctcagag attggaggct ctccccgacc tcccaatccc tgtctcagga     3720

gaggaggagg ccgtattgta gtcccatgag catagctatg tgtccccatc cccatgtgac     3780

aagagaagag gactggggcc aagtaggtga ggtgacaggg ctgaggccag ctctgcaact     3840

tattagctgt ttgatcttta aaaagttact cgatctccat gagcctcagt ttccatacgt     3900

gtaaaagggg gatgatcata gcatctacca tgtgggcttg cagtgcagag tatttgaatt     3960

agacacagaa cagtgaggat caggatggcc tctcacccac ctgcctttct gcccagctgc     4020

ccacactgcc cctagtcatg gtggcaccct ccggggcacg gctgggcccc ttgccccact     4080

tacaggcact cctccaggac aggccacatt tcatgcacca ggtatggacg gtgaatggat     4140

cctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg     4200

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4260

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc cagctggcgt     4320

aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa     4380

tggcgattcc gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga     4440

tagtttgagt tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac     4500

aacggttaat ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa     4560

cacttctcag gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt     4620

tagctcccgc tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat     4680

agtacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     4740

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     4800

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     4860

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     4920

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     4980

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     5040

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     5100

ttaacgcgaa ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct     5160

tcctgttttt ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt     5220

tacgattacc gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag     5280

cctttgtaga gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac     5340

ggttgaatat catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc     5400

tttacctaca cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta     5460

tccttgcgtt gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg     5520

tacaaccgat ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc     5580

ttgcctgtat gatttattgg atgttggaat cgcctgatgc ggtattttct ccttacgcat     5640

ctgtgcggta tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca     5700

tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     5760

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     5820

ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta     5880

taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat     5940

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     6000

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa     6060

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac     6120

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac     6180

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt     6240

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc     6300

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca     6360

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc     6420

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     6480

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     6540

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     6600

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     6660

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     6720

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     6780

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     6840

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     6900

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     6960

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     7020

taacgtgagt tttcgttcca ctgagcgtca gacccc                               7056


<210>  37
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  38
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  39
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  naked FRB wild type polypeptide

<400>  39

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  40
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  naked FRB mutant polypeptide

<400>  40

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  41
<211>  4187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DISC vector DNA

<400>  41
gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc       60

cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt      120

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc      180

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc      240

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc      300

tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgct agcaccggtg      360

ccgccaccat gcctctgggc ctgctgtggc tgggcctggc cctgctgggc gccctgcacg      420

cccaggccgg cgtgcaggtg gagacaatct ccccaggcga cggacgcaca ttccctaagc      480

ggggccagac ctgcgttgtg cactatacag gcatgctgga ggatggcaag aagtttgaca      540

gctcccggga tagaaacaag ccattcaagt ttatgctggg caagcaggaa gtgatcagag      600

gctgggagga gggcgtggcc cagatgtctg tgggccagag ggccaagctg accatcagcc      660

cagactacgc ctatggagca acaggccacc caggaatcat cccacctcac gccaccctgg      720

tgttcgatgt ggagctgctg aagctgggcg agggatccaa cacatcaaaa gagaacccct      780

ttctgttcgc attggaggcc gtagtcatat ctgttggatc catgggactt attatctccc      840

tgttgtgtgt gtacttctgg ctggaacgga ctatgcccag gatccccacg ctcaagaatc      900

tggaagatct cgtcacagaa taccatggta atttcagcgc ctggagcgga gtctctaagg      960

gtctggccga atccctccaa cccgattatt ctgaacggtt gtgcctcgta tccgaaatac     1020

caccaaaagg cggggctctg ggtgagggcc caggggcgag tccgtgcaat caacacagcc     1080

cgtattgggc ccctccttgt tatacgttga agcccgaaac tggaagcgga gctactaact     1140

tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctatg gcactgcccg     1200

tgaccgccct gctgctgcct ctggccctgc tgctgcacgc agcccggcct atcctgtggc     1260

acgagatgtg gcacgagggc ctggaggagg ccagcaggct gtattttggc gagcgcaacg     1320

tgaagggcat gttcgaggtg ctggagcctc tgcacgccat gatggagaga ggcccacaga     1380

ccctgaagga gacatccttt aaccaggcct atggacggga cctgatggag gcacaggagt     1440

ggtgcagaaa gtacatgaag tctggcaatg tgaaggacct gctgcaggcc tgggatctgt     1500

actatcacgt gtttcggaga atctccaagg gcaaagacac gattccgtgg cttgggcatc     1560

tgctcgttgg gctgagtggt gcgtttggtt tcatcatctt ggtctatctc ttgatcaatt     1620

gcagaaatac aggcccttgg ctgaaaaaag tgctcaagtg taataccccc gacccaagca     1680

agttcttctc ccagctttct tcagagcatg gaggcgatgt gcagaaatgg ctctcttcac     1740

cttttccctc ctcaagcttc tccccgggag ggctggcgcc cgagatttca cctcttgagg     1800

tacttgaacg agacaaggtt acccaacttc tccttcaaca ggataaggta cccgaacctg     1860

cgagccttag ctccaaccac tctcttacga gctgcttcac caatcaggga tacttctttt     1920

tccaccttcc cgatgcgctg gaaatcgaag cttgtcaagt ttactttacc tatgatccat     1980

atagcgagga agatcccgac gaaggagtcg ccggtgcgcc cacgggttcc tcaccccaac     2040

ctctccagcc tctctcagga gaagatgatg cttattgcac ttttcccagt agagacgatc     2100

tcctcctctt ttctccatct cttttggggg gaccttcccc cccttctacg gcacctggcg     2160

ggtctggtgc tggcgaggag cggatgccgc cgtccctcca ggagcgagta ccacgagatt     2220

gggatcccca gccacttgga ccccccaccc ccggcgtacc tgaccttgtc gattttcaac     2280

ctccccctga attggtgctg cgagaggctg gggaggaagt tccggacgct gggccgaggg     2340

agggcgtgtc ctttccatgg agtaggcctc caggtcaagg cgagtttagg gctctcaacg     2400

cgcggctgcc gttgaataca gacgcttatc tctcactgca ggaactgcaa ggtcaggacc     2460

caacacatct tgtaggatct ggtgctacta atttttctct tttgaagcaa gctggagatg     2520

ttgaagagaa ccccggtccg gagatgtggc atgagggtct ggaagaagcg tctcgactgt     2580

actttggtga gcgcaatgtg aagggcatgt ttgaagtcct cgaacccctt catgccatga     2640

tggaacgcgg accccagacc ttgaaggaga caagttttaa ccaagcttac ggaagagacc     2700

tgatggaagc ccaggaatgg tgcaggaaat acatgaaaag cgggaatgtg aaggacttgc     2760

tccaagcgtg ggacctgtac tatcatgtct ttaggcgcat tagtaagggc agcggcgcca     2820

ccaacttcag cctgctgaag caggccggcg acgtggagga gaaccccggc cccgtgagca     2880

agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag gtgcacatgg     2940

agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc cgcccctacg     3000

agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc ttcgcctggg     3060

acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac cccgccgaca     3120

tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc gtgatgaact     3180

tcgaggacgg cggcgtggtg accgtgaccc aggactcctc tctgcaggac ggcgagttca     3240

tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta atgcagaaga     3300

agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc gccctgaagg     3360

gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct gaggtcaaga     3420

ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc aacatcaagt     3480

tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa cgcgccgagg     3540

gccgccactc caccggcggc atggacgagc tgtacaagtg aactagtgtc gacaatcaac     3600

ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta     3660

cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt     3720

tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg     3780

ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg     3840

gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca     3900

cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca     3960

ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg     4020

ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag     4080

cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc     4140

gccctcagac gagtcggatc tccctttggg ccgcctcccc gcctgga                   4187


<210>  42
<211>  393
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  uDISC DNA cytoplasmic tail only codon diverged

<400>  42
ccagcagctc tcggcaaaga cacgattccg tggcttgggc atctgctcgt tgggctgagc       60

ggtgcgtttg gtttcatcat cttggtctat ctcttgatca attgcagaaa tacaggccct      120

tggctgaaaa aagtgctcaa gtgtaatacc cccgacccaa gcaagttctt ctcccagctt      180

tcttcagagc atggaggcga tgtgcagaaa tggctctctt caccttttcc ctcctcaagc      240

ttctccccgg gagggctggc gcccgagatt tcacctcttg aggtacttga acgagacaag      300

gttacccaac ttctccttca acaggataag gtacccgaac ctgcgagcct tagcttgaat      360

acagacgctt atctctcact gcaggaactg caa                                   393


<210>  43
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  uDISC polypeptide cytoplasmic tail only

<400>  43

Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu 
1               5                   10                  15      


Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys 
        35                  40                  45              


Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His 
    50                  55                  60                  


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
65                  70                  75                  80  


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
                85                  90                  95      


Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro 
            100                 105                 110         


Glu Pro Ala Ser Leu Ser Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        115                 120                 125             


Glu Leu Gln 
    130     


<210>  44
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  FKBP CISC domain

<400>  44

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
            100                 105             


<210>  45
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Entire uDISC polypeptide FRB truncated IL2Rbeta

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His 
        115                 120                 125             


Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr 
    130                 135                 140                 


Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu 
145                 150                 155                 160 


Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser 
                165                 170                 175     


Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser 
            180                 185                 190         


Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu 
        195                 200                 205             


Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys 
    210                 215                 220                 


Val Pro Glu Pro Ala Ser Leu Ser Leu Asn Thr Asp Ala Tyr Leu Ser 
225                 230                 235                 240 


Leu Gln Glu Leu Gln 
                245 


<210>  46
<211>  3623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  uDISC vector DNA

<400>  46
gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc       60

cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt      120

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc      180

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc      240

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc      300

tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgct agcaccggtg      360

ccgccaccat gcctctgggc ctgctgtggc tgggcctggc cctgctgggc gccctgcacg      420

cccaggccgg cgtgcaggtg gagacaatct ccccaggcga cggacgcaca ttccctaagc      480

ggggccagac ctgcgttgtg cactatacag gcatgctgga ggatggcaag aagtttgaca      540

gctcccggga tagaaacaag ccattcaagt ttatgctggg caagcaggaa gtgatcagag      600

gctgggagga gggcgtggcc cagatgtctg tgggccagag ggccaagctg accatcagcc      660

cagactacgc ctatggagca acaggccacc caggaatcat cccacctcac gccaccctgg      720

tgttcgatgt ggagctgctg aagctgggcg agggatccaa cacatcaaaa gagaacccct      780

ttctgttcgc attggaggcc gtagtcatat ctgttggatc catgggactt attatctccc      840

tgttgtgtgt gtacttctgg ctggaacgga ctatgcccag gatccccacg ctcaagaatc      900

tggaagatct cgtcacagaa taccatggta atttcagcgc ctggagcgga gtctctaagg      960

gtctggccga atccctccaa cccgattatt ctgaacggtt gtgcctcgta tccgaaatac     1020

caccaaaagg cggggctctg ggtgagggcc caggggcgag tccgtgcaat caacacagcc     1080

cgtattgggc ccctccttgt tatacgttga agcccgaaac tggaagcgga gctactaact     1140

tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctatg gcactgcccg     1200

tgaccgccct gctgctgcct ctggccctgc tgctgcacgc agcccggcct atcctgtggc     1260

acgagatgtg gcacgagggc ctggaggagg ccagcaggct gtattttggc gagcgcaacg     1320

tgaagggcat gttcgaggtg ctggagcctc tgcacgccat gatggagaga ggcccacaga     1380

ccctgaagga gacatccttt aaccaggcct atggacggga cctgatggag gcacaggagt     1440

ggtgcagaaa gtacatgaag tctggcaatg tgaaggacct gctgcaggcc tgggatctgt     1500

actatcacgt gtttcggaga atctccaagg gcaaagacac gattccgtgg cttgggcatc     1560

tgctcgttgg gctgagtggt gcgtttggtt tcatcatctt ggtctatctc ttgatcaatt     1620

gcagaaatac aggcccttgg ctgaaaaaag tgctcaagtg taataccccc gacccaagca     1680

agttcttctc ccagctttct tcagagcatg gaggcgatgt gcagaaatgg ctctcttcac     1740

cttttccctc ctcaagcttc tccccgggag ggctggcgcc cgagatttca cctcttgagg     1800

tacttgaacg agacaaggtt acccaacttc tccttcaaca ggataaggta cccgaacctg     1860

cgagccttag cttgaataca gacgcttatc tctcactgca ggaactgcaa ggatctggtg     1920

ctactaattt ttctcttttg aagcaagctg gagatgttga agagaacccc ggtccggaga     1980

tgtggcatga gggtctggaa gaagcgtctc gactgtactt tggtgagcgc aatgtgaagg     2040

gcatgtttga agtcctcgaa ccccttcatg ccatgatgga acgcggaccc cagaccttga     2100

aggagacaag ttttaaccaa gcttacggaa gagacctgat ggaagcccag gaatggtgca     2160

ggaaatacat gaaaagcggg aatgtgaagg acttgctcca agcgtgggac ctgtactatc     2220

atgtctttag gcgcattagt aagggcagcg gcgccaccaa cttcagcctg ctgaagcagg     2280

ccggcgacgt ggaggagaac cccggccccg tgagcaaggg cgaggaggat aacatggcca     2340

tcatcaagga gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt     2400

tcgagatcga gggcgagggc gagggccgcc cctacgaggg cacccagacc gccaagctga     2460

aggtgaccaa gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt     2520

acggctccaa ggcctacgtg aagcaccccg ccgacatccc cgactacttg aagctgtcct     2580

tccccgaggg cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg     2640

tgacccagga ctcctctctg caggacggcg agttcatcta caaggtgaag ctgcgcggca     2700

ccaacttccc ctccgacggc cccgtaatgc agaagaagac catgggctgg gaggcctcct     2760

ccgagcggat gtaccccgag gacggcgccc tgaagggcga gatcaagcag aggctgaagc     2820

tgaaggacgg cggccactac gacgctgagg tcaagaccac ctacaaggcc aagaagcccg     2880

tgcagctgcc cggcgcctac aacgtcaaca tcaagttgga catcacctcc cacaacgagg     2940

actacaccat cgtggaacag tacgaacgcg ccgagggccg ccactccacc ggcggcatgg     3000

acgagctgta caagtgaact agtgtcgaca atcaacctct ggattacaaa atttgtgaaa     3060

gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa     3120

tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat     3180

cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt     3240

gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc     3300

tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc     3360

ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg     3420

ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga     3480

cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc     3540

tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc     3600

tttgggccgc ctccccgcct gga                                             3623


<210>  47
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC polypeptide

<400>  47

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  48
<211>  352
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC polypeptide

<400>  48

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Gly Ser Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr 
    130                 135                 140                 


Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg 
145                 150                 155                 160 


Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp 
                165                 170                 175     


Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser 
            180                 185                 190         


Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser 
        195                 200                 205             


Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser 
    210                 215                 220                 


His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu 
225                 230                 235                 240 


Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile 
                245                 250                 255     


Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg 
            260                 265                 270         


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
        275                 280                 285             


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
    290                 295                 300                 


Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro 
305                 310                 315                 320 


Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln 
                325                 330                 335     


His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345                 350         


<210>  49
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC polypeptide

<400>  49

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys 
    130                 135                 140                 


Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn 
145                 150                 155                 160 


His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser 
                165                 170                 175     


Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser 
            180                 185                 190         


Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn 
        195                 200                 205             


Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile 
    210                 215                 220                 


His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu 
225                 230                 235                 240 


Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu 
                245                 250                 255     


Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr 
            260                 265                 270         


Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser 
        275                 280                 285             


Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp 
    290                 295                 300                 


Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly 
305                 310                 315                 320 


Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro 
                325                 330                 335     


Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345                 


<210>  50
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC polypeptide

<400>  50

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  51
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC polypeptide

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
        115                 120                 125             


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
    130                 135                 140                 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
145                 150                 155                 160 


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
                165                 170                 175     


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
            180                 185                 190         


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
        195                 200                 205             


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
    210                 215                 220                 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
225                 230                 235                 240 


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
                245                 250                 255     


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
            260                 265                 270         


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
        275                 280                 285             


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
    290                 295                 300                 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
305                 310                 315                 320 


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
                325                 330                 335     


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
            340                 345                 350         


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
        355                 360                 365             


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
    370                 375                 380                 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
385                 390                 395                 400 


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
                405                 410                 415     


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            420                 425                 


<210>  52
<211>  543
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC polypeptide

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Gly Ser Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
        115                 120                 125             


Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser 
    130                 135                 140                 


Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
145                 150                 155                 160 


Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                165                 170                 175     


Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr 
            180                 185                 190         


Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
        195                 200                 205             


Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
    210                 215                 220                 


Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu 
225                 230                 235                 240 


Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu 
                245                 250                 255     


Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys 
            260                 265                 270         


Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Gln Leu Ser Ser Glu His 
        275                 280                 285             


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
    290                 295                 300                 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
305                 310                 315                 320 


Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro 
                325                 330                 335     


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
            340                 345                 350         


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
        355                 360                 365             


Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
    370                 375                 380                 


Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu 
385                 390                 395                 400 


Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg 
                405                 410                 415     


Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro 
            420                 425                 430         


Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro 
        435                 440                 445             


Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu 
    450                 455                 460                 


Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro 
465                 470                 475                 480 


Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly 
                485                 490                 495     


Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly 
            500                 505                 510         


Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr 
        515                 520                 525             


Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    530                 535                 540             


<210>  53
<211>  541
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC polypeptide

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
        115                 120                 125             


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
    130                 135                 140                 


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
145                 150                 155                 160 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
                165                 170                 175     


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
            180                 185                 190         


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
        195                 200                 205             


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
    210                 215                 220                 


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
225                 230                 235                 240 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
                245                 250                 255     


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
            260                 265                 270         


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
        275                 280                 285             


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
    290                 295                 300                 


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
305                 310                 315                 320 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
                325                 330                 335     


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
            340                 345                 350         


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
        355                 360                 365             


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
    370                 375                 380                 


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
                405                 410                 415     


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
            420                 425                 430         


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
        435                 440                 445             


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
    450                 455                 460                 


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
465                 470                 475                 480 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
                485                 490                 495     


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
            500                 505                 510         


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
        515                 520                 525             


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    530                 535                 540     


<210>  54
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL7Ralpha_CISC polypeptide

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Trp Leu Gly His Leu Leu Val Gly Leu Ser 
65                  70                  75                  80  


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
                85                  90                  95      


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
            100                 105                 110         


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
        115                 120                 125             


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
    130                 135                 140                 


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
145                 150                 155                 160 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
                165                 170                 175     


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
            180                 185                 190         


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
        195                 200                 205             


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
    210                 215                 220                 


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
225                 230                 235                 240 


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
                245                 250                 255     


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
            260                 265                 270         


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
        275                 280                 285             


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
    290                 295                 300                 


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
305                 310                 315                 320 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
                325                 330                 335     


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
            340                 345                 350         


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        355                 360                 365             


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    370                 375                 


<210>  55
<211>  345
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL7Ralpha_CISC polypeptide

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu 
        115                 120                 125             


Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile 
    130                 135                 140                 


Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro 
145                 150                 155                 160 


Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro 
                165                 170                 175     


Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys 
            180                 185                 190         


Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly 
        195                 200                 205             


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
    210                 215                 220                 


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
225                 230                 235                 240 


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
                245                 250                 255     


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
            260                 265                 270         


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
        275                 280                 285             


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
    290                 295                 300                 


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
305                 310                 315                 320 


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
                325                 330                 335     


Thr Met Ser Ser Phe Tyr Gln Asn Gln 
            340                 345 


<210>  56
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker polypeptide

<400>  56

Gly Gly Gly Ser 
1               


<210>  57
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker polypeptide

<400>  57

Gly Gly Gly Ser Gly Gly Gly 
1               5           


<210>  58
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker polypeptide

<400>  58

Gly Gly Gly 
1           


<210>  59
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker polypeptide

<400>  59

Gly Gly Ser 
1           


<210>  60
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  linker polypeptide

<400>  60

Gly Gly Ser Pro 
1               


<210>  61
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC polypeptide

<400>  61

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  62
<211>  443
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC polypeptide

<400>  62

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser 
    130                 135                 140                 


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
145                 150                 155                 160 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
                165                 170                 175     


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
            180                 185                 190         


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
        195                 200                 205             


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
    210                 215                 220                 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
225                 230                 235                 240 


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
                245                 250                 255     


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
            260                 265                 270         


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
        275                 280                 285             


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
    290                 295                 300                 


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
305                 310                 315                 320 


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
                325                 330                 335     


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
            340                 345                 350         


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
        355                 360                 365             


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
    370                 375                 380                 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
385                 390                 395                 400 


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
                405                 410                 415     


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
            420                 425                 430         


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        435                 440             


<210>  63
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Ralpha_CISC polypeptide

<400>  63

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile 
    130                 135                 140                 


Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys 
145                 150                 155                 160 


Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro 
                165                 170                 175     


Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn 
            180                 185                 190         


Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His 
        195                 200                 205             


Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
    210                 215                 220                 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
225                 230                 235                 240 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
                245                 250                 255     


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
            260                 265                 270         


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
        275                 280                 285             


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
    290                 295                 300                 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
                325                 330                 335     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            340                 345                 350         


Ser Phe Tyr Gln Asn Gln 
        355             


<210>  64
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL7Ralpha_CISC polypeptide

<400>  64

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile 
    130                 135                 140                 


Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys 
145                 150                 155                 160 


Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro 
                165                 170                 175     


Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn 
            180                 185                 190         


Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His 
        195                 200                 205             


Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
    210                 215                 220                 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
225                 230                 235                 240 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
                245                 250                 255     


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
            260                 265                 270         


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
        275                 280                 285             


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
    290                 295                 300                 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
                325                 330                 335     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            340                 345                 350         


Ser Phe Tyr Gln Asn Gln 
        355             


<210>  65
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  MPL_CISC polypeptide

<400>  65

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly 
    130                 135                 140                 


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
145                 150                 155                 160 


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
                165                 170                 175     


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
            180                 185                 190         


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
        195                 200                 205             


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys 
    210                 215                 220                 


Ser Ser Gln Ala Gln Met Asp Tyr Arg Arg Leu Gln Pro Ser Cys Leu 
225                 230                 235                 240 


Gly Thr Met Pro Leu Ser Val Cys Pro Pro Met Ala Glu Ser Gly Ser 
                245                 250                 255     


Cys Cys Thr Thr His Ile Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr 
            260                 265                 270         


Trp Gln Gln Pro 
        275     


<210>  66
<211>  9405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISC vector DNA

<400>  66
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gggatccaac acatcaaaag     2760

agaacccctt tctgttcgca ttggaggccg tagtcatatc tgttggatcc atgggactta     2820

ttatctccct gttgtgtgtg tacttctggc tggaacggac tatgcccagg atccccacgc     2880

tcaagaatct ggaagatctc gtcacagaat accatggtaa tttcagcgcc tggagcggag     2940

tctctaaggg tctggccgaa tccctccaac ccgattattc tgaacggttg tgcctcgtat     3000

ccgaaatacc accaaaaggc ggggctctgg gtgagggccc aggggcgagt ccgtgcaatc     3060

aacacagccc gtattgggcc cctccttgtt atacgttgaa gcccgaaact ggaagcggag     3120

ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctatgg     3180

cactgcccgt gaccgccctg ctgctgcctc tggccctgct gctgcacgca gcccggccta     3240

tcctgtggca cgagatgtgg cacgagggcc tggaggaggc cagcaggctg tattttggcg     3300

agcgcaacgt gaagggcatg ttcgaggtgc tggagcctct gcacgccatg atggagagag     3360

gcccacagac cctgaaggag acatccttta accaggccta tggacgggac ctgatggagg     3420

cacaggagtg gtgcagaaag tacatgaagt ctggcaatgt gaaggacctg ctgcaggcct     3480

gggatctgta ctatcacgtg tttcggagaa tctccaaggg caaagacacg attccgtggc     3540

ttgggcatct gctcgttggg ctgagtggtg cgtttggttt catcatcttg gtctatctct     3600

tgatcaattg cagaaataca ggcccttggc tgaaaaaagt gctcaagtgt aatacccccg     3660

acccaagcaa gttcttctcc cagctttctt cagagcatgg aggcgatgtg cagaaatggc     3720

tctcttcacc ttttccctcc tcaagcttct ccccgggagg gctggcgccc gagatttcac     3780

ctcttgaggt acttgaacga gacaaggtta cccaacttct ccttcaacag gataaggtac     3840

ccgaacctgc gagccttagc tccaaccact ctcttacgag ctgcttcacc aatcagggat     3900

acttcttttt ccaccttccc gatgcgctgg aaatcgaagc ttgtcaagtt tactttacct     3960

atgatccata tagcgaggaa gatcccgacg aaggagtcgc cggtgcgccc acgggttcct     4020

caccccaacc tctccagcct ctctcaggag aagatgatgc ttattgcact tttcccagta     4080

gagacgatct cctcctcttt tctccatctc ttttgggggg accttccccc ccttctacgg     4140

cacctggcgg gtctggtgct ggcgaggagc ggatgccgcc gtccctccag gagcgagtac     4200

cacgagattg ggatccccag ccacttggac cccccacccc cggcgtacct gaccttgtcg     4260

attttcaacc tccccctgaa ttggtgctgc gagaggctgg ggaggaagtt ccggacgctg     4320

ggccgaggga gggcgtgtcc tttccatgga gtaggcctcc aggtcaaggc gagtttaggg     4380

ctctcaacgc gcggctgccg ttgaatacag acgcttatct ctcactgcag gaactgcaag     4440

gtcaggaccc aacacatctt gtaggatctg gtgctactaa tttttctctt ttgaagcaag     4500

ctggagatgt tgaagagaac cctggtccag tgagcaaggg cgaggagctg ttcaccgggg     4560

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     4620

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     4680

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     4740

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     4800

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     4860

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     4920

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     4980

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     5040

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     5100

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     5160

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     5220

tcggcatgga cgagctgtac aagtaaacta gtgtcgacaa tcaacctctg gattacaaaa     5280

tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg     5340

ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct     5400

tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg     5460

gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct     5520

gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg     5580

ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg     5640

tgttgtcggg gaagctgacg tcctttccat ggctgctcgc ctgtgttgcc acctggattc     5700

tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc     5760

gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc     5820

ggatctccct ttgggccgcc tccccgcctg gaattcgagc tcggtacctt taagaccaat     5880

gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg     5940

gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt     6000

agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca     6060

ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa     6120

ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta gtagttcatg     6180

tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa     6240

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     6300

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     6360

tcatgtctgg ctctagctat cccgccccta actccgccca gttccgccca ttctccgccc     6420

catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta     6480

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcgtcga gacgtaccca     6540

attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg     6600

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     6660

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     6720

atggcgaatg gcgcgacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     6780

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     6840

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     6900

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     6960

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     7020

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     7080

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     7140

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcccaggtgg     7200

cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa     7260

tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa     7320

gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct     7380

tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg     7440

tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg     7500

ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt     7560

atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga     7620

cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga     7680

attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac     7740

gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg     7800

ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac     7860

gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct     7920

agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct     7980

gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg     8040

gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat     8100

ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg     8160

tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat     8220

tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct     8280

catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     8340

gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     8400

aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     8460

gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta     8520

gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     8580

gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     8640

atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     8700

cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     8760

cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     8820

agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     8880

tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     8940

gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     9000

catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg     9060

agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc     9120

ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     9180

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag     9240

ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg     9300

tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa     9360

gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgca                     9405


<210>  67
<211>  10053
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISC vector DNA

<400>  67
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gggcggtagt cagaaccttg     2760

tgataccatg ggccccagaa aatctcacac ttcataaact ttccgaatca caactcgaac     2820

tcaactggaa taaccggttc ctgaatcact gtcttgaaca cctggtacaa tatcggaccg     2880

actgggatca ctcatggaca gaacaatctg tggactatag gcacaaattc tcactcccaa     2940

gcgtagacgg ccaaaaaaga tacacttttc gcgtacgatc ccgctttaat cctctctgcg     3000

gctctgctca gcactggagt gaatggtccc atcccattca ttggggatcc aacacatcaa     3060

aagagaaccc ctttctgttc gcattggagg ccgtagtcat atctgttgga tccatgggac     3120

ttattatctc cctgttgtgt gtgtacttct ggctggaacg gactatgccc aggatcccca     3180

cgctcaagaa tctggaagat ctcgtcacag aataccatgg taatttcagc gcctggagcg     3240

gagtctctaa gggtctggcc gaatccctcc aacccgatta ttctgaacgg ttgtgcctcg     3300

tatccgaaat accaccaaaa ggcggggctc tgggtgaggg cccaggggcg agtccgtgca     3360

atcaacacag cccgtattgg gcccctcctt gttatacgtt gaagcccgaa actggaagcg     3420

gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac cctggaccta     3480

tggcactgcc cgtgaccgcc ctgctgctgc ctctggccct gctgctgcac gcagcccggc     3540

ctatcctgtg gcacgagatg tggcacgagg gcctggagga ggccagcagg ctgtattttg     3600

gcgagcgcaa cgtgaagggc atgttcgagg tgctggagcc tctgcacgcc atgatggaga     3660

gaggcccaca gaccctgaag gagacatcct ttaaccaggc ctatggacgg gacctgatgg     3720

aggcacagga gtggtgcaga aagtacatga agtctggcaa tgtgaaggac ctgctgcagg     3780

cctgggatct gtactatcac gtgtttcgga gaatctccaa gggaggttca aaaccttttg     3840

agaaccttag actgatggcg cccatctctc tgcaggtagt tcacgttgag acccatagat     3900

gcaatataag ctgggaaatc tcacaagcca gccattactt tgaacggcat ttggaattcg     3960

aggcccgaac actttccccc ggtcatacgt gggaagaagc tcctctcttg acgctgaagc     4020

agaagcagga gtggatttgt ctggagactt tgactcctga tactcagtat gagttccaag     4080

ttcgggtgaa accactccaa ggcgagttca cgacgtggtc tccgtggagt caaccgttgg     4140

cgttccgcac gaagcccgct gcccttggca aagacacgat tccgtggctt gggcatctgc     4200

tcgttgggct gagtggtgcg tttggtttca tcatcttggt ctatctcttg atcaattgca     4260

gaaatacagg cccttggctg aaaaaagtgc tcaagtgtaa tacccccgac ccaagcaagt     4320

tcttctccca gctttcttca gagcatggag gcgatgtgca gaaatggctc tcttcacctt     4380

ttccctcctc aagcttctcc ccgggagggc tggcgcccga gatttcacct cttgaggtac     4440

ttgaacgaga caaggttacc caacttctcc ttcaacagga taaggtaccc gaacctgcga     4500

gccttagctc caaccactct cttacgagct gcttcaccaa tcagggatac ttctttttcc     4560

accttcccga tgcgctggaa atcgaagctt gtcaagttta ctttacctat gatccatata     4620

gcgaggaaga tcccgacgaa ggagtcgccg gtgcgcccac gggttcctca ccccaacctc     4680

tccagcctct ctcaggagaa gatgatgctt attgcacttt tcccagtaga gacgatctcc     4740

tcctcttttc tccatctctt ttggggggac cttccccccc ttctacggca cctggcgggt     4800

ctggtgctgg cgaggagcgg atgccgccgt ccctccagga gcgagtacca cgagattggg     4860

atccccagcc acttggaccc cccacccccg gcgtacctga ccttgtcgat tttcaacctc     4920

cccctgaatt ggtgctgcga gaggctgggg aggaagttcc ggacgctggg ccgagggagg     4980

gcgtgtcctt tccatggagt aggcctccag gtcaaggcga gtttagggct ctcaacgcgc     5040

ggctgccgtt gaatacagac gcttatctct cactgcagga actgcaaggt caggacccaa     5100

cacatcttgt aggatctggt gctactaatt tttctctttt gaagcaagct ggagatgttg     5160

aagagaaccc tggtccagtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc     5220

tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg     5280

gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg     5340

tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc     5400

ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg     5460

agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg     5520

agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca     5580

acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg     5640

acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca     5700

gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc     5760

tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc     5820

gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg     5880

agctgtacaa gtaaactagt gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat     5940

tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc     6000

ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct     6060

ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca     6120

ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt     6180

ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg     6240

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga     6300

agctgacgtc ctttccatgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt     6360

ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc     6420

cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt     6480

gggccgcctc cccgcctgga attcgagctc ggtaccttta agaccaatga cttacaaggc     6540

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc     6600

ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg     6660

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc     6720

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct     6780

cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat     6840

tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc     6900

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     6960

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct     7020

ctagctatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     7080

atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag     7140

tgaggaggct tttttggagg cctaggcttt tgcgtcgaga cgtacccaat tcgccctata     7200

gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc     7260

ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata     7320

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc     7380

gcgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     7440

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     7500

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     7560

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     7620

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     7680

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     7740

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     7800

ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc ccaggtggca cttttcgggg     7860

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     7920

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     7980

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     8040

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     8100

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     8160

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     8220

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     8280

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     8340

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     8400

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     8460

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     8520

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     8580

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     8640

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     8700

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     8760

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     8820

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     8880

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     8940

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     9000

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     9060

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     9120

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     9180

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     9240

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     9300

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     9360

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     9420

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     9480

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     9540

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     9600

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     9660

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     9720

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     9780

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     9840

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     9900

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     9960

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa    10020

ccctcactaa agggaacaaa agctggagct gca                                 10053


<210>  68
<211>  10035
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISC vector DNA

<400>  68
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gcaaaacttg gtgattcctt     2760

gggccccaga aaatctcacg cttcacaagt tgtccgaatc ccagctcgag ctcaactgga     2820

ataatagatt tcttaatcat tgtttggaac acctggttca atatagaacg gattgggacc     2880

actcatggac cgagcagtca gttgactacc gccacaaatt ttcacttccc agcgtagatg     2940

ggcagaagag gtacacattt agggtcagat ccaggtttaa tcctctgtgt ggttctgctc     3000

aacactggtc tgagtggagc catccgatcc actggggctc aaatacctct aaagaaaatc     3060

cgttcctctt tgcgctcgaa gccgttgtta tcagcgtcgg aagcatggga cttatcattt     3120

cccttctctg cgtgtacttc tggctggagc ggacgatgcc gcggattccg acgctcaaaa     3180

acctggagga ccttgtaaca gaatatcacg gtaatttctc cgcttggagt ggcgtatcaa     3240

aggggcttgc tgagtccctt caaccggatt actctgagcg cctctgcttg gtgtccgaga     3300

tacctcccaa aggaggtgca cttggggagg ggccaggcgc gtccccttgc aatcagcata     3360

gtccgtattg ggcgcccccc tgttataccc tcaaaccgga aacgggaagc ggagctacta     3420

acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct atggcactgc     3480

ccgtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcccgg cctatcctgt     3540

ggcacgagat gtggcacgag ggcctggagg aggccagcag gctgtatttt ggcgagcgca     3600

acgtgaaggg catgttcgag gtgctggagc ctctgcacgc catgatggag agaggcccac     3660

agaccctgaa ggagacatcc tttaaccagg cctatggacg ggacctgatg gaggcacagg     3720

agtggtgcag aaagtacatg aagtctggca atgtgaagga cctgctgcag gcctgggatc     3780

tgtactatca cgtgtttcgg agaatctcca agaaaccttt tgagaacctt agactgatgg     3840

cgcccatctc tctgcaggta gttcacgttg agacccatag atgcaatata agctgggaaa     3900

tctcacaagc cagccattac tttgaacggc atttggaatt cgaggcccga acactttccc     3960

ccggtcatac gtgggaagaa gctcctctct tgacgctgaa gcagaagcag gagtggattt     4020

gtctggagac tttgactcct gatactcagt atgagttcca agttcgggtg aaaccactcc     4080

aaggcgagtt cacgacgtgg tctccgtgga gtcaaccgtt ggcgttccgc acgaagcccg     4140

ctgcccttgg caaagacacg attccgtggc ttgggcatct gctcgttggg ctgagtggtg     4200

cgtttggttt catcatcttg gtctatctct tgatcaattg cagaaataca ggcccttggc     4260

tgaaaaaagt gctcaagtgt aatacccccg acccaagcaa gttcttctcc cagctttctt     4320

cagagcatgg aggcgatgtg cagaaatggc tctcttcacc ttttccctcc tcaagcttct     4380

ccccgggagg gctggcgccc gagatttcac ctcttgaggt acttgaacga gacaaggtta     4440

cccaacttct ccttcaacag gataaggtac ccgaacctgc gagccttagc tccaaccact     4500

ctcttacgag ctgcttcacc aatcagggat acttcttttt ccaccttccc gatgcgctgg     4560

aaatcgaagc ttgtcaagtt tactttacct atgatccata tagcgaggaa gatcccgacg     4620

aaggagtcgc cggtgcgccc acgggttcct caccccaacc tctccagcct ctctcaggag     4680

aagatgatgc ttattgcact tttcccagta gagacgatct cctcctcttt tctccatctc     4740

ttttgggggg accttccccc ccttctacgg cacctggcgg gtctggtgct ggcgaggagc     4800

ggatgccgcc gtccctccag gagcgagtac cacgagattg ggatccccag ccacttggac     4860

cccccacccc cggcgtacct gaccttgtcg attttcaacc tccccctgaa ttggtgctgc     4920

gagaggctgg ggaggaagtt ccggacgctg ggccgaggga gggcgtgtcc tttccatgga     4980

gtaggcctcc aggtcaaggc gagtttaggg ctctcaacgc gcggctgccg ttgaatacag     5040

acgcttatct ctcactgcag gaactgcaag gtcaggaccc aacacatctt gtaggatctg     5100

gtgctactaa tttttctctt ttgaagcaag ctggagatgt tgaagagaac cctggtccag     5160

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     5220

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     5280

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     5340

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     5400

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     5460

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     5520

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     5580

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     5640

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     5700

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     5760

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     5820

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaacta     5880

gtgtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact     5940

atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg     6000

cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg     6060

aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa     6120

cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc     6180

ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg     6240

ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat     6300

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt     6360

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc     6420

cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcctg     6480

gaattcgagc tcggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca     6540

ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct     6600

gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     6660

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     6720

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     6780

gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt tataacttgc     6840

aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa     6900

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     6960

tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta     7020

actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca     7080

gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga     7140

ggcctaggct tttgcgtcga gacgtaccca attcgcccta tagtgagtcg tattacgcgc     7200

gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta     7260

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg     7320

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcgacgcg ccctgtagcg     7380

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     7440

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     7500

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     7560

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     7620

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     7680

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     7740

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca     7800

aaatattaac gtttacaatt tcccaggtgg cacttttcgg ggaaatgtgc gcggaacccc     7860

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     7920

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc     7980

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt     8040

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct     8100

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac     8160

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact     8220

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa     8280

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga     8340

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt     8400

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga     8460

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg     8520

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat     8580

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat     8640

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc     8700

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga     8760

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc     8820

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     8880

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     8940

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     9000

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     9060

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     9120

accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     9180

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     9240

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     9300

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     9360

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag     9420

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     9480

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     9540

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     9600

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc     9660

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac     9720

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct     9780

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc     9840

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt     9900

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac     9960

aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca    10020

aaagctggag ctgca                                                     10035


<210>  69
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Linker spacer polypeptide

<400>  69

Pro Ala Ala Leu 
1               


<210>  70
<211>  267
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Naked FRB domain nucleic acid sequence

<400>  70
gagatgtggc atgagggtct ggaagaagcg tctcgactgt actttggtga gcgcaatgtg       60

aagggcatgt ttgaagtcct cgaacccctt catgccatga tggaacgcgg accccagacc      120

ttgaaggaga caagttttaa ccaagcttac ggaagagacc tgatggaagc ccaggaatgg      180

tgcaggaaat acatgaaaag cgggaatgtg aaggacttga cccaagcgtg ggacctgtac      240

tatcatgtct ttaggcgcat tagtaag                                          267


<210>  71
<211>  353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MND promoter

<400>  71
gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc       60

cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt      120

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc      180

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc      240

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc      300

tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgct agc             353


<210>  72
<211>  2190
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  FOXP3cDNA_P2A_LNGFR kozak_start codon_FOXP3cDNA_P2A_LNGFR_stop 
       codon

<400>  72
gccaccatgc ctaatcctcg gcctggaaag cctagcgctc cttctcttgc tctgggacct       60

tctcctggcg cctctccatc ttggagagcc gctcctaaag ccagcgatct gctgggagct      120

agaggacctg gcggcacatt tcagggcaga gatcttagag gcggagccca cgctagctcc      180

tccagcctta atcctatgcc tcctagccag ctccagctgc ctacactgcc tctggttatg      240

gtggctccta gcggagctag actgggccct ctgcctcatc tgcaagctct gctgcaggac      300

agaccccact tcatgcacca gctgagcacc gtggatgccc acgcaagaac acctgtgctg      360

caggttcacc ctctggaatc cccagccatg atcagcctga cacctccaac aacagccacc      420

ggcgtgttca gcctgaaagc cagacctgga ctgcctcctg gcatcaatgt ggccagcctg      480

gaatgggtgt ccagagaacc tgctctgctg tgcacattcc ccaatccaag cgctcccaga      540

aaggacagca cactgtctgc cgtgcctcag agcagctatc ccctgcttgc taacggcgtg      600

tgcaagtggc ctggatgcga gaaggtgttc gaggaacccg aggacttcct gaagcactgc      660

caggccgatc atctgctgga cgagaaaggc agagcccagt gtctgctcca gcgcgagatg      720

gtgcagtctc tggaacagca gctggtcctg gaaaaagaaa agctgagcgc catgcaggcc      780

cacctggccg gaaaaatggc cctgacaaag gccagcagcg tggcctcttc tgataagggc      840

agctgctgca ttgtggccgc tggatctcag ggacctgtgg ttcctgcttg gagcggacct      900

agagaggccc ctgattctct gtttgccgtg cggagacacc tgtggggctc tcacggcaac      960

tctactttcc ccgagttcct gcacaacatg gactacttca agttccacaa catgcggcct     1020

ccattcacct acgccacact gatcagatgg gccattctgg aagcccctga gaagcagaga     1080

accctgaacg agatctacca ctggtttacc cggatgttcg ccttcttccg gaatcaccct     1140

gccacctgga agaacgccat ccggcacaat ctgagcctgc acaagtgctt cgtgcgcgtg     1200

gaatctgaga aaggcgccgt gtggacagtg gacgagctgg aattcagaaa gaagagaagc     1260

cagcggccta gccggtgcag caatcctaca cctggacctg gaagcggagc gactaacttc     1320

agcctgctga agcaggccgg agatgtggag gaaaaccctg gaccgatggg ggcaggtgcc     1380

accggacgag ccatggacgg gccgcgcctg ctgctgttgc tgcttctggg ggtgtccctt     1440

ggaggtgcca aggaggcatg ccccacaggc ctgtacacac acagcggtga gtgctgcaaa     1500

gcctgcaacc tgggcgaggg tgtggcccag ccttgtggag ccaaccagac cgtgtgtgag     1560

ccctgcctgg acagcgtgac gttctccgac gtggtgagcg cgaccgagcc gtgcaagccg     1620

tgcaccgagt gcgtggggct ccagagcatg tcggcgccgt gcgtggaggc cgacgacgcc     1680

gtgtgccgct gcgcctacgg ctactaccag gatgagacga ctgggcgctg cgaggcgtgc     1740

cgcgtgtgcg aggcgggctc gggcctcgtg ttctcctgcc aggacaagca gaacaccgtg     1800

tgcgaggagt gccccgacgg cacgtattcc gacgaggcca accacgtgga cccgtgcctg     1860

ccctgcaccg tgtgcgagga caccgagcgc cagctccgcg agtgcacacg ctgggccgac     1920

gccgagtgcg aggagatccc tggccgttgg attacacggt ccacaccccc agagggctcg     1980

gacagcacag cccccagcac ccaggagcct gaggcacctc cagaacaaga cctcatagcc     2040

agcacggtgg caggtgtggt gaccacagtg atgggcagct cccagcccgt ggtgacccga     2100

ggcaccaccg acaacctcat ccctgtctat tgctccatcc tggctgctgt ggttgtgggt     2160

cttgtggcct acatagcctt caagaggtga                                      2190


<210>  73
<211>  2190
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LNGFR_P2A_FOXP3cDNA kozak_start codon_LNGFR_P2A_FOXP3cDNA_stop 
       codon

<400>  73
gccaccatgg gggcaggtgc caccggacga gccatggacg ggccgcgcct gctgctgttg       60

ctgcttctgg gggtgtccct tggaggtgcc aaggaggcat gccccacagg cctgtacaca      120

cacagcggtg agtgctgcaa agcctgcaac ctgggcgagg gtgtggccca gccttgtgga      180

gccaaccaga ccgtgtgtga gccctgcctg gacagcgtga cgttctccga cgtggtgagc      240

gcgaccgagc cgtgcaagcc gtgcaccgag tgcgtggggc tccagagcat gtcggcgccg      300

tgcgtggagg ccgacgacgc cgtgtgccgc tgcgcctacg gctactacca ggatgagacg      360

actgggcgct gcgaggcgtg ccgcgtgtgc gaggcgggct cgggcctcgt gttctcctgc      420

caggacaagc agaacaccgt gtgcgaggag tgccccgacg gcacgtattc cgacgaggcc      480

aaccacgtgg acccgtgcct gccctgcacc gtgtgcgagg acaccgagcg ccagctccgc      540

gagtgcacac gctgggccga cgccgagtgc gaggagatcc ctggccgttg gattacacgg      600

tccacacccc cagagggctc ggacagcaca gcccccagca cccaggagcc tgaggcacct      660

ccagaacaag acctcatagc cagcacggtg gcaggtgtgg tgaccacagt gatgggcagc      720

tcccagcccg tggtgacccg aggcaccacc gacaacctca tccctgtcta ttgctccatc      780

ctggctgctg tggttgtggg tcttgtggcc tacatagcct tcaagagggg aagcggagcg      840

actaacttca gcctgctgaa gcaggccgga gatgtggagg aaaaccctgg accgatgcct      900

aatcctcggc ctggaaagcc tagcgctcct tctcttgctc tgggaccttc tcctggcgcc      960

tctccatctt ggagagccgc tcctaaagcc agcgatctgc tgggagctag aggacctggc     1020

ggcacatttc agggcagaga tcttagaggc ggagcccacg ctagctcctc cagccttaat     1080

cctatgcctc ctagccagct ccagctgcct acactgcctc tggttatggt ggctcctagc     1140

ggagctagac tgggccctct gcctcatctg caagctctgc tgcaggacag accccacttc     1200

atgcaccagc tgagcaccgt ggatgcccac gcaagaacac ctgtgctgca ggttcaccct     1260

ctggaatccc cagccatgat cagcctgaca cctccaacaa cagccaccgg cgtgttcagc     1320

ctgaaagcca gacctggact gcctcctggc atcaatgtgg ccagcctgga atgggtgtcc     1380

agagaacctg ctctgctgtg cacattcccc aatccaagcg ctcccagaaa ggacagcaca     1440

ctgtctgccg tgcctcagag cagctatccc ctgcttgcta acggcgtgtg caagtggcct     1500

ggatgcgaga aggtgttcga ggaacccgag gacttcctga agcactgcca ggccgatcat     1560

ctgctggacg agaaaggcag agcccagtgt ctgctccagc gcgagatggt gcagtctctg     1620

gaacagcagc tggtcctgga aaaagaaaag ctgagcgcca tgcaggccca cctggccgga     1680

aaaatggccc tgacaaaggc cagcagcgtg gcctcttctg ataagggcag ctgctgcatt     1740

gtggccgctg gatctcaggg acctgtggtt cctgcttgga gcggacctag agaggcccct     1800

gattctctgt ttgccgtgcg gagacacctg tggggctctc acggcaactc tactttcccc     1860

gagttcctgc acaacatgga ctacttcaag ttccacaaca tgcggcctcc attcacctac     1920

gccacactga tcagatgggc cattctggaa gcccctgaga agcagagaac cctgaacgag     1980

atctaccact ggtttacccg gatgttcgcc ttcttccgga atcaccctgc cacctggaag     2040

aacgccatcc ggcacaatct gagcctgcac aagtgcttcg tgcgcgtgga atctgagaaa     2100

ggcgccgtgt ggacagtgga cgagctggaa ttcagaaaga agagaagcca gcggcctagc     2160

cggtgcagca atcctacacc tggaccttga                                      2190


<210>  74
<211>  3261
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  FOXP3cDNA_uDISC nucleotide sequence  coding sequence only codon 
       optimized our DISC architecture version 6

<400>  74
atgcctaatc ctcggcctgg aaagcctagc gctccttctc ttgctctggg accttctcct       60

ggcgcctctc catcttggag agccgctcct aaagccagcg atctgctggg agctagagga      120

cctggcggca catttcaggg cagagatctt agaggcggag cccacgctag ctcctccagc      180

cttaatccta tgcctcctag ccagctccag ctgcctacac tgcctctggt tatggtggct      240

cctagcggag ctagactggg ccctctgcct catctgcaag ctctgctgca ggacagaccc      300

cacttcatgc accagctgag caccgtggat gcccacgcaa gaacacctgt gctgcaggtt      360

caccctctgg aatccccagc catgatcagc ctgacacctc caacaacagc caccggcgtg      420

ttcagcctga aagccagacc tggactgcct cctggcatca atgtggccag cctggaatgg      480

gtgtccagag aacctgctct gctgtgcaca ttccccaatc caagcgctcc cagaaaggac      540

agcacactgt ctgccgtgcc tcagagcagc tatcccctgc ttgctaacgg cgtgtgcaag      600

tggcctggat gcgagaaggt gttcgaggaa cccgaggact tcctgaagca ctgccaggcc      660

gatcatctgc tggacgagaa aggcagagcc cagtgtctgc tccagcgcga gatggtgcag      720

tctctggaac agcagctggt cctggaaaaa gaaaagctga gcgccatgca ggcccacctg      780

gccggaaaaa tggccctgac aaaggccagc agcgtggcct cttctgataa gggcagctgc      840

tgcattgtgg ccgctggatc tcagggacct gtggttcctg cttggagcgg acctagagag      900

gcccctgatt ctctgtttgc cgtgcggaga cacctgtggg gctctcacgg caactctact      960

ttccccgagt tcctgcacaa catggactac ttcaagttcc acaacatgcg gcctccattc     1020

acctacgcca cactgatcag atgggccatt ctggaagccc ctgagaagca gagaaccctg     1080

aacgagatct accactggtt tacccggatg ttcgccttct tccggaatca ccctgccacc     1140

tggaagaacg ccatccggca caatctgagc ctgcacaagt gcttcgtgcg cgtggaatct     1200

gagaaaggcg ccgtgtggac agtggacgag ctggaattca gaaagaagag aagccagcgg     1260

cctagccggt gcagcaatcc tacacctgga cctggaagcg gagcgactaa cttcagcctg     1320

cttaagcagg ccggagatgt ggaggaaaac cctggaccga tgcctctggg cctgctgtgg     1380

ctgggcctgg ccctgctggg cgccctgcac gcccaggccg gcgtgcaggt ggagacaatc     1440

tccccaggcg acggacgcac attccctaag cggggccaga cctgcgtggt gcactataca     1500

ggcatgctgg aggatggcaa gaagtttgac agctcccggg atagaaacaa gccattcaag     1560

tttatgctgg gcaagcagga agtgatcaga ggctgggagg agggcgtggc ccagatgtct     1620

gtgggccaga gggccaagct gaccatcagc ccagactacg cctatggagc aacaggccac     1680

ccaggaatca tcccacctca cgccaccctg gtgttcgatg tggagctgct gaagctgggc     1740

gagggagggt cacctggatc caacacatca aaagagaacc cctttctgtt cgcattggag     1800

gccgtagtca tatctgttgg atccatggga cttattatct ccctgttgtg tgtgtacttc     1860

tggctggaac ggactatgcc caggatcccc acgctcaaga atctggaaga tctcgtcaca     1920

gaataccatg gtaatttcag cgcctggagc ggagtctcta agggtctggc cgaatccctc     1980

caacccgatt attctgaacg gttgtgcctc gtatccgaaa taccaccaaa aggcggggct     2040

ctgggtgagg gcccaggggc gagtccgtgc aatcaacaca gcccgtattg ggcccctcct     2100

tgttatacgt tgaagcccga aactggaagc ggagctacta acttcagcct gctgaagcag     2160

gctggagacg tggaggagaa ccctggacct atggcactgc ccgtgaccgc cctgctgctg     2220

cctctggccc tgctgctgca cgcagcccgg cctatcctgt ggcacgagat gtggcacgag     2280

ggcctggagg aggccagcag gctgtatttt ggcgagcgca acgtgaaggg catgttcgag     2340

gtgctggagc ctctgcacgc catgatggag agaggcccac agaccctgaa ggagacatcc     2400

tttaaccagg cctatggacg ggacctgatg gaggcacagg agtggtgcag aaagtacatg     2460

aagtctggca atgtgaagga cctgctgcag gcctgggatc tgtactatca cgtgtttcgg     2520

agaatctcca agccagcagc tctcggcaaa gacacgattc cgtggcttgg gcatctgctc     2580

gttgggctga gcggtgcgtt tggtttcatc atcttggtct atctcttgat caattgcaga     2640

aatacaggcc cttggctgaa aaaagtgctc aagtgtaata cccccgaccc aagcaagttc     2700

ttctcccagc tttcttcaga gcatggaggc gatgtgcaga aatggctctc ttcacctttt     2760

ccctcctcaa gcttctcccc gggagggctg gcgcccgaga tttcacctct tgaggtactt     2820

gaacgagaca aggttaccca acttctcctt caacaggata aggtacccga acctgcgagc     2880

cttagcttga atacagacgc ttatctctca ctgcaggaac tgcaaggatc tggtgctact     2940

aatttttctc ttttgaagca agctggagat gttgaagaga accccggtcc ggagatgtgg     3000

catgagggtc tggaagaagc gtctcgactg tactttggtg agcgcaatgt gaagggcatg     3060

tttgaagtcc tcgaacccct tcatgccatg atggaacgcg gaccccagac cttgaaggag     3120

acaagtttta accaagctta cggaagagac ctgatggaag cccaggaatg gtgcaggaaa     3180

tacatgaaaa gcgggaatgt gaaggacttg ctccaagcgt gggacctgta ctatcatgtc     3240

tttaggcgca ttagtaagtg a                                               3261


<210>  75
<211>  3805
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MND_FOXP3cDNA_uDISC_SV40 polyA nucleotide sequence codon 
       optimized 

<400>  75
gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc       60

cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt      120

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc      180

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc      240

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc      300

tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc      360

atccacgctg ttttgacttc catagaagga tctcgaggcc accatgccta atcctcggcc      420

tggaaagcct agcgctcctt ctcttgctct gggaccttct cctggcgcct ctccatcttg      480

gagagccgct cctaaagcca gcgatctgct gggagctaga ggacctggcg gcacatttca      540

gggcagagat cttagaggcg gagcccacgc tagctcctcc agccttaatc ctatgcctcc      600

tagccagctc cagctgccta cactgcctct ggttatggtg gctcctagcg gagctagact      660

gggccctctg cctcatctgc aagctctgct gcaggacaga ccccacttca tgcaccagct      720

gagcaccgtg gatgcccacg caagaacacc tgtgctgcag gttcaccctc tggaatcccc      780

agccatgatc agcctgacac ctccaacaac agccaccggc gtgttcagcc tgaaagccag      840

acctggactg cctcctggca tcaatgtggc cagcctggaa tgggtgtcca gagaacctgc      900

tctgctgtgc acattcccca atccaagcgc tcccagaaag gacagcacac tgtctgccgt      960

gcctcagagc agctatcccc tgcttgctaa cggcgtgtgc aagtggcctg gatgcgagaa     1020

ggtgttcgag gaacccgagg acttcctgaa gcactgccag gccgatcatc tgctggacga     1080

gaaaggcaga gcccagtgtc tgctccagcg cgagatggtg cagtctctgg aacagcagct     1140

ggtcctggaa aaagaaaagc tgagcgccat gcaggcccac ctggccggaa aaatggccct     1200

gacaaaggcc agcagcgtgg cctcttctga taagggcagc tgctgcattg tggccgctgg     1260

atctcaggga cctgtggttc ctgcttggag cggacctaga gaggcccctg attctctgtt     1320

tgccgtgcgg agacacctgt ggggctctca cggcaactct actttccccg agttcctgca     1380

caacatggac tacttcaagt tccacaacat gcggcctcca ttcacctacg ccacactgat     1440

cagatgggcc attctggaag cccctgagaa gcagagaacc ctgaacgaga tctaccactg     1500

gtttacccgg atgttcgcct tcttccggaa tcaccctgcc acctggaaga acgccatccg     1560

gcacaatctg agcctgcaca agtgcttcgt gcgcgtggaa tctgagaaag gcgccgtgtg     1620

gacagtggac gagctggaat tcagaaagaa gagaagccag cggcctagcc ggtgcagcaa     1680

tcctacacct ggacctggaa gcggagcgac taacttcagc ctgcttaagc aggccggaga     1740

tgtggaggaa aaccctggac cgatgcctct gggcctgctg tggctgggcc tggccctgct     1800

gggcgccctg cacgcccagg ccggcgtgca ggtggagaca atctccccag gcgacggacg     1860

cacattccct aagcggggcc agacctgcgt ggtgcactat acaggcatgc tggaggatgg     1920

caagaagttt gacagctccc gggatagaaa caagccattc aagtttatgc tgggcaagca     1980

ggaagtgatc agaggctggg aggagggcgt ggcccagatg tctgtgggcc agagggccaa     2040

gctgaccatc agcccagact acgcctatgg agcaacaggc cacccaggaa tcatcccacc     2100

tcacgccacc ctggtgttcg atgtggagct gctgaagctg ggcgagggag ggtcacctgg     2160

atccaacaca tcaaaagaga acccctttct gttcgcattg gaggccgtag tcatatctgt     2220

tggatccatg ggacttatta tctccctgtt gtgtgtgtac ttctggctgg aacggactat     2280

gcccaggatc cccacgctca agaatctgga agatctcgtc acagaatacc atggtaattt     2340

cagcgcctgg agcggagtct ctaagggtct ggccgaatcc ctccaacccg attattctga     2400

acggttgtgc ctcgtatccg aaataccacc aaaaggcggg gctctgggtg agggcccagg     2460

ggcgagtccg tgcaatcaac acagcccgta ttgggcccct ccttgttata cgttgaagcc     2520

cgaaactgga agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga     2580

gaaccctgga cctatggcac tgcccgtgac cgccctgctg ctgcctctgg ccctgctgct     2640

gcacgcagcc cggcctatcc tgtggcacga gatgtggcac gagggcctgg aggaggccag     2700

caggctgtat tttggcgagc gcaacgtgaa gggcatgttc gaggtgctgg agcctctgca     2760

cgccatgatg gagagaggcc cacagaccct gaaggagaca tcctttaacc aggcctatgg     2820

acgggacctg atggaggcac aggagtggtg cagaaagtac atgaagtctg gcaatgtgaa     2880

ggacctgctg caggcctggg atctgtacta tcacgtgttt cggagaatct ccaagccagc     2940

agctctcggc aaagacacga ttccgtggct tgggcatctg ctcgttgggc tgagcggtgc     3000

gtttggtttc atcatcttgg tctatctctt gatcaattgc agaaatacag gcccttggct     3060

gaaaaaagtg ctcaagtgta atacccccga cccaagcaag ttcttctccc agctttcttc     3120

agagcatgga ggcgatgtgc agaaatggct ctcttcacct tttccctcct caagcttctc     3180

cccgggaggg ctggcgcccg agatttcacc tcttgaggta cttgaacgag acaaggttac     3240

ccaacttctc cttcaacagg ataaggtacc cgaacctgcg agccttagct tgaatacaga     3300

cgcttatctc tcactgcagg aactgcaagg atctggtgct actaattttt ctcttttgaa     3360

gcaagctgga gatgttgaag agaaccccgg tccggagatg tggcatgagg gtctggaaga     3420

agcgtctcga ctgtactttg gtgagcgcaa tgtgaagggc atgtttgaag tcctcgaacc     3480

ccttcatgcc atgatggaac gcggacccca gaccttgaag gagacaagtt ttaaccaagc     3540

ttacggaaga gacctgatgg aagcccagga atggtgcagg aaatacatga aaagcgggaa     3600

tgtgaaggac ttgctccaag cgtgggacct gtactatcat gtctttaggc gcattagtaa     3660

gtgagtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat     3720

aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg     3780

ggagatgtgg gaggtttttt aaagc                                           3805


<210>  76
<211>  1086
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  FOXP3cDNA_uDISC amino acid sequence

<400>  76

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro Gly 
            420                 425                 430         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        435                 440                 445             


Glu Asn Pro Gly Pro Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala 
    450                 455                 460                 


Leu Leu Gly Ala Leu His Ala Gln Ala Gly Val Gln Val Glu Thr Ile 
465                 470                 475                 480 


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
                485                 490                 495     


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
            500                 505                 510         


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
        515                 520                 525             


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
    530                 535                 540                 


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
545                 550                 555                 560 


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
                565                 570                 575     


Leu Lys Leu Gly Glu Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu 
            580                 585                 590         


Asn Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser 
        595                 600                 605             


Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg 
    610                 615                 620                 


Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr 
625                 630                 635                 640 


Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu 
                645                 650                 655     


Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser 
            660                 665                 670         


Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser 
        675                 680                 685             


Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu 
    690                 695                 700                 


Lys Pro Glu Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
705                 710                 715                 720 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
                725                 730                 735     


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile 
            740                 745                 750         


Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
        755                 760                 765             


Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
    770                 775                 780                 


Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
785                 790                 795                 800 


Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
                805                 810                 815     


Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp 
            820                 825                 830         


Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu 
        835                 840                 845             


Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser 
    850                 855                 860                 


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
865                 870                 875                 880 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
                885                 890                 895     


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
            900                 905                 910         


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
        915                 920                 925             


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
    930                 935                 940                 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
945                 950                 955                 960 


Leu Ser Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
                965                 970                 975     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            980                 985                 990         


Glu Asn Pro Gly Pro Glu Met Trp  His Glu Gly Leu Glu  Glu Ala Ser 
        995                 1000                 1005             


Arg Leu  Tyr Phe Gly Glu Arg  Asn Val Lys Gly Met  Phe Glu Val 
    1010                 1015                 1020             


Leu Glu  Pro Leu His Ala Met  Met Glu Arg Gly Pro  Gln Thr Leu 
    1025                 1030                 1035             


Lys Glu  Thr Ser Phe Asn Gln  Ala Tyr Gly Arg Asp  Leu Met Glu 
    1040                 1045                 1050             


Ala Gln  Glu Trp Cys Arg Lys  Tyr Met Lys Ser Gly  Asn Val Lys 
    1055                 1060                 1065             


Asp Leu  Leu Gln Ala Trp Asp  Leu Tyr Tyr His Val  Phe Arg Arg 
    1070                 1075                 1080             


Ile Ser  Lys 
    1085     


<210>  77
<211>  4080
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  FOXP3cDNA_LNGFRe_uDISC nucleotide sequence coding sequence only 

<400>  77
atgcctaatc ctcggcctgg aaagcctagc gctccttctc ttgctctggg accttctcct       60

ggcgcctctc catcttggag agccgctcct aaagccagcg atctgctggg agctagagga      120

cctggcggca catttcaggg cagagatctt agaggcggag cccacgctag ctcctccagc      180

cttaatccta tgcctcctag ccagctccag ctgcctacac tgcctctggt tatggtggct      240

cctagcggag ctagactggg ccctctgcct catctgcaag ctctgctgca ggacagaccc      300

cacttcatgc accagctgag caccgtggat gcccacgcaa gaacacctgt gctgcaggtt      360

caccctctgg aatccccagc catgatcagc ctgacacctc caacaacagc caccggcgtg      420

ttcagcctga aagccagacc tggactgcct cctggcatca atgtggccag cctggaatgg      480

gtgtccagag aacctgctct gctgtgcaca ttccccaatc caagcgctcc cagaaaggac      540

agcacactgt ctgccgtgcc tcagagcagc tatcccctgc ttgctaacgg cgtgtgcaag      600

tggcctggat gcgagaaggt gttcgaggaa cccgaggact tcctgaagca ctgccaggcc      660

gatcatctgc tggacgagaa aggcagagcc cagtgtctgc tccagcgcga gatggtgcag      720

tctctggaac agcagctggt cctggaaaaa gaaaagctga gcgccatgca ggcccacctg      780

gccggaaaaa tggccctgac aaaggccagc agcgtggcct cttctgataa gggcagctgc      840

tgcattgtgg ccgctggatc tcagggacct gtggttcctg cttggagcgg acctagagag      900

gcccctgatt ctctgtttgc cgtgcggaga cacctgtggg gctctcacgg caactctact      960

ttccccgagt tcctgcacaa catggactac ttcaagttcc acaacatgcg gcctccattc     1020

acctacgcca cactgatcag atgggccatt ctggaagccc ctgagaagca gagaaccctg     1080

aacgagatct accactggtt tacccggatg ttcgccttct tccggaatca ccctgccacc     1140

tggaagaacg ccatccggca caatctgagc ctgcacaagt gcttcgtgcg cgtggaatct     1200

gagaaaggcg ccgtgtggac agtggacgag ctggaattca gaaagaagag aagccagcgg     1260

cctagccggt gcagcaatcc tacacctgga cctggaagcg gagcgactaa cttcagcctg     1320

cttaagcagg ccggagatgt ggaggaaaac cctggaccga tgcctctggg cctgctgtgg     1380

ctgggcctgg ccctgctggg cgccctgcac gcccaggcca tgggggcagg tgccaccgga     1440

cgagccatgg acgggccgcg cctgctgctg ttgctgcttc tgggggtgtc ccttggaggt     1500

gccaaggagg catgccccac aggcctgtac acacacagcg gtgagtgctg caaagcctgc     1560

aacctgggcg agggtgtggc ccagccttgt ggagccaacc agaccgtgtg tgagccctgc     1620

ctggacagcg tgacgttctc cgacgtggtg agcgcgaccg agccgtgcaa gccgtgcacc     1680

gagtgcgtgg ggctccagag catgtcggcg ccgtgcgtgg aggccgacga cgccgtgtgc     1740

cgctgcgcct acggctacta ccaggatgag acgactgggc gctgcgaggc gtgccgcgtg     1800

tgcgaggcgg gctcgggcct cgtgttctcc tgccaggaca agcagaacac cgtgtgcgag     1860

gagtgccccg acggcacgta ttccgacgag gccaaccacg tggacccgtg cctgccctgc     1920

accgtgtgcg aggacaccga gcgccagctc cgcgagtgca cacgctgggc cgacgccgag     1980

tgcgaggaga tccctggccg ttggattaca cggtccacac ccccagaggg ctcggacagc     2040

acagccccca gcacccagga gcctgaggca cctccagaac aagacctcat agccagcacg     2100

gtggcaggtg tggtgaccac agtgatgggc agctcccagc ccgtggtgac ccgaggcacc     2160

accgacaacc tcatccctgt ctattgctcc atcctggctg ctgtggttgt gggtcttgtg     2220

gcctacatag ccttcaagag gggcgtgcag gtggagacaa tctccccagg cgacggacgc     2280

acattcccta agcggggcca gacctgcgtg gtgcactata caggcatgct ggaggatggc     2340

aagaagtttg acagctcccg ggatagaaac aagccattca agtttatgct gggcaagcag     2400

gaagtgatca gaggctggga ggagggcgtg gcccagatgt ctgtgggcca gagggccaag     2460

ctgaccatca gcccagacta cgcctatgga gcaacaggcc acccaggaat catcccacct     2520

cacgccaccc tggtgttcga tgtggagctg ctgaagctgg gcgagggagg gtcacctgga     2580

tccaacacat caaaagagaa cccctttctg ttcgcattgg aggccgtagt catatctgtt     2640

ggatccatgg gacttattat ctccctgttg tgtgtgtact tctggctgga acggactatg     2700

cccaggatcc ccacgctcaa gaatctggaa gatctcgtca cagaatacca tggtaatttc     2760

agcgcctgga gcggagtctc taagggtctg gccgaatccc tccaacccga ttattctgaa     2820

cggttgtgcc tcgtatccga aataccacca aaaggcgggg ctctgggtga gggcccaggg     2880

gcgagtccgt gcaatcaaca cagcccgtat tgggcccctc cttgttatac gttgaagccc     2940

gaaactggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     3000

aaccctggac ctatggcact gcccgtgacc gccctgctgc tgcctctggc cctgctgctg     3060

cacgcagccc ggcctatcct gtggcacgag atgtggcacg agggcctgga ggaggccagc     3120

aggctgtatt ttggcgagcg caacgtgaag ggcatgttcg aggtgctgga gcctctgcac     3180

gccatgatgg agagaggccc acagaccctg aaggagacat cctttaacca ggcctatgga     3240

cgggacctga tggaggcaca ggagtggtgc agaaagtaca tgaagtctgg caatgtgaag     3300

gacctgctgc aggcctggga tctgtactat cacgtgtttc ggagaatctc caagccagca     3360

gctctcggca aagacacgat tccgtggctt gggcatctgc tcgttgggct gagcggtgcg     3420

tttggtttca tcatcttggt ctatctcttg atcaattgca gaaatacagg cccttggctg     3480

aaaaaagtgc tcaagtgtaa tacccccgac ccaagcaagt tcttctccca gctttcttca     3540

gagcatggag gcgatgtgca gaaatggctc tcttcacctt ttccctcctc aagcttctcc     3600

ccgggagggc tggcgcccga gatttcacct cttgaggtac ttgaacgaga caaggttacc     3660

caacttctcc ttcaacagga taaggtaccc gaacctgcga gccttagctt gaatacagac     3720

gcttatctct cactgcagga actgcaagga tctggtgcta ctaatttttc tcttttgaag     3780

caagctggag atgttgaaga gaaccccggt ccggagatgt ggcatgaggg tctggaagaa     3840

gcgtctcgac tgtactttgg tgagcgcaat gtgaagggca tgtttgaagt cctcgaaccc     3900

cttcatgcca tgatggaacg cggaccccag accttgaagg agacaagttt taaccaagct     3960

tacggaagag acctgatgga agcccaggaa tggtgcagga aatacatgaa aagcgggaat     4020

gtgaaggact tgctccaagc gtgggacctg tactatcatg tctttaggcg cattagtaag     4080


<210>  78
<211>  1360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  FOXP3cDNA_LNGFRe_uDISC amino acid sequence

<400>  78

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro Gly 
            420                 425                 430         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        435                 440                 445             


Glu Asn Pro Gly Pro Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala 
    450                 455                 460                 


Leu Leu Gly Ala Leu His Ala Gln Ala Met Gly Ala Gly Ala Thr Gly 
465                 470                 475                 480 


Arg Ala Met Asp Gly Pro Arg Leu Leu Leu Leu Leu Leu Leu Gly Val 
                485                 490                 495     


Ser Leu Gly Gly Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His 
            500                 505                 510         


Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln 
        515                 520                 525             


Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val 
    530                 535                 540                 


Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr 
545                 550                 555                 560 


Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp 
                565                 570                 575     


Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr 
            580                 585                 590         


Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val 
        595                 600                 605             


Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp 
    610                 615                 620                 


Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys 
625                 630                 635                 640 


Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp 
                645                 650                 655     


Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser 
            660                 665                 670         


Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro 
        675                 680                 685             


Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val 
    690                 695                 700                 


Val Thr Thr Val Met Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr 
705                 710                 715                 720 


Thr Asp Asn Leu Ile Pro Val Tyr Cys Ser Ile Leu Ala Ala Val Val 
                725                 730                 735     


Val Gly Leu Val Ala Tyr Ile Ala Phe Lys Arg Gly Val Gln Val Glu 
            740                 745                 750         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        755                 760                 765             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    770                 775                 780                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
785                 790                 795                 800 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                805                 810                 815     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            820                 825                 830         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        835                 840                 845             


Glu Leu Leu Lys Leu Gly Glu Gly Gly Ser Pro Gly Ser Asn Thr Ser 
    850                 855                 860                 


Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val 
865                 870                 875                 880 


Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu 
                885                 890                 895     


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
            900                 905                 910         


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
        915                 920                 925             


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
    930                 935                 940                 


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
945                 950                 955                 960 


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
                965                 970                 975     


Thr Leu Lys Pro Glu Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
            980                 985                 990         


Lys Gln Ala Gly Asp Val Glu Glu  Asn Pro Gly Pro Met  Ala Leu Pro 
        995                 1000                 1005             


Val Thr  Ala Leu Leu Leu Pro  Leu Ala Leu Leu Leu  His Ala Ala 
    1010                 1015                 1020             


Arg Pro  Ile Leu Trp His Glu  Met Trp His Glu Gly  Leu Glu Glu 
    1025                 1030                 1035             


Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn Val Lys  Gly Met Phe 
    1040                 1045                 1050             


Glu Val  Leu Glu Pro Leu His  Ala Met Met Glu Arg  Gly Pro Gln 
    1055                 1060                 1065             


Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala Tyr Gly  Arg Asp Leu 
    1070                 1075                 1080             


Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr Met Lys  Ser Gly Asn 
    1085                 1090                 1095             


Val Lys  Asp Leu Leu Gln Ala  Trp Asp Leu Tyr Tyr  His Val Phe 
    1100                 1105                 1110             


Arg Arg  Ile Ser Lys Pro Ala  Ala Leu Gly Lys Asp  Thr Ile Pro 
    1115                 1120                 1125             


Trp Leu  Gly His Leu Leu Val  Gly Leu Ser Gly Ala  Phe Gly Phe 
    1130                 1135                 1140             


Ile Ile  Leu Val Tyr Leu Leu  Ile Asn Cys Arg Asn  Thr Gly Pro 
    1145                 1150                 1155             


Trp Leu  Lys Lys Val Leu Lys  Cys Asn Thr Pro Asp  Pro Ser Lys 
    1160                 1165                 1170             


Phe Phe  Ser Gln Leu Ser Ser  Glu His Gly Gly Asp  Val Gln Lys 
    1175                 1180                 1185             


Trp Leu  Ser Ser Pro Phe Pro  Ser Ser Ser Phe Ser  Pro Gly Gly 
    1190                 1195                 1200             


Leu Ala  Pro Glu Ile Ser Pro  Leu Glu Val Leu Glu  Arg Asp Lys 
    1205                 1210                 1215             


Val Thr  Gln Leu Leu Leu Gln  Gln Asp Lys Val Pro  Glu Pro Ala 
    1220                 1225                 1230             


Ser Leu  Ser Leu Asn Thr Asp  Ala Tyr Leu Ser Leu  Gln Glu Leu 
    1235                 1240                 1245             


Gln Gly  Ser Gly Ala Thr Asn  Phe Ser Leu Leu Lys  Gln Ala Gly 
    1250                 1255                 1260             


Asp Val  Glu Glu Asn Pro Gly  Pro Glu Met Trp His  Glu Gly Leu 
    1265                 1270                 1275             


Glu Glu  Ala Ser Arg Leu Tyr  Phe Gly Glu Arg Asn  Val Lys Gly 
    1280                 1285                 1290             


Met Phe  Glu Val Leu Glu Pro  Leu His Ala Met Met  Glu Arg Gly 
    1295                 1300                 1305             


Pro Gln  Thr Leu Lys Glu Thr  Ser Phe Asn Gln Ala  Tyr Gly Arg 
    1310                 1315                 1320             


Asp Leu  Met Glu Ala Gln Glu  Trp Cys Arg Lys Tyr  Met Lys Ser 
    1325                 1330                 1335             


Gly Asn  Val Lys Asp Leu Leu  Gln Ala Trp Asp Leu  Tyr Tyr His 
    1340                 1345                 1350             


Val Phe  Arg Arg Ile Ser Lys  
    1355                 1360 


<210>  79
<211>  3258
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  uDISC_FOXP3cDNA nucleotide sequence  coding sequence only

<400>  79
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagctact      780

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatggcactg      840

cccgtgaccg ccctgctgct gcctctggcc ctgctgctgc acgcagcccg gcctatcctg      900

tggcacgaga tgtggcacga gggcctggag gaggccagca ggctgtattt tggcgagcgc      960

aacgtgaagg gcatgttcga ggtgctggag cctctgcacg ccatgatgga gagaggccca     1020

cagaccctga aggagacatc ctttaaccag gcctatggac gggacctgat ggaggcacag     1080

gagtggtgca gaaagtacat gaagtctggc aatgtgaagg acctgctgca ggcctgggat     1140

ctgtactatc acgtgtttcg gagaatctcc aagccagcag ctctcggcaa agacacgatt     1200

ccgtggcttg ggcatctgct cgttgggctg agcggtgcgt ttggtttcat catcttggtc     1260

tatctcttga tcaattgcag aaatacaggc ccttggctga aaaaagtgct caagtgtaat     1320

acccccgacc caagcaagtt cttctcccag ctttcttcag agcatggagg cgatgtgcag     1380

aaatggctct cttcaccttt tccctcctca agcttctccc cgggagggct ggcgcccgag     1440

atttcacctc ttgaggtact tgaacgagac aaggttaccc aacttctcct tcaacaggat     1500

aaggtacccg aacctgcgag ccttagcttg aatacagacg cttatctctc actgcaggaa     1560

ctgcaaggat ctggtgctac taatttttct cttttgaagc aagctggaga tgttgaagag     1620

aaccccggtc cggagatgtg gcatgagggt ctggaagaag cgtctcgact gtactttggt     1680

gagcgcaatg tgaagggcat gtttgaagtc ctcgaacccc ttcatgccat gatggaacgc     1740

ggaccccaga ccttgaagga gacaagtttt aaccaagctt acggaagaga cctgatggaa     1800

gcccaggaat ggtgcaggaa atacatgaaa agcgggaatg tgaaggactt gctccaagcg     1860

tgggacctgt actatcatgt ctttaggcgc attagtaagg gaagcggagc gactaacttc     1920

agcctgctta agcaggccgg agatgtggag gaaaaccctg gaccgatgcc taatcctcgg     1980

cctggaaagc ctagcgctcc ttctcttgct ctgggacctt ctcctggcgc ctctccatct     2040

tggagagccg ctcctaaagc cagcgatctg ctgggagcta gaggacctgg cggcacattt     2100

cagggcagag atcttagagg cggagcccac gctagctcct ccagccttaa tcctatgcct     2160

cctagccagc tccagctgcc tacactgcct ctggttatgg tggctcctag cggagctaga     2220

ctgggccctc tgcctcatct gcaagctctg ctgcaggaca gaccccactt catgcaccag     2280

ctgagcaccg tggatgccca cgcaagaaca cctgtgctgc aggttcaccc tctggaatcc     2340

ccagccatga tcagcctgac acctccaaca acagccaccg gcgtgttcag cctgaaagcc     2400

agacctggac tgcctcctgg catcaatgtg gccagcctgg aatgggtgtc cagagaacct     2460

gctctgctgt gcacattccc caatccaagc gctcccagaa aggacagcac actgtctgcc     2520

gtgcctcaga gcagctatcc cctgcttgct aacggcgtgt gcaagtggcc tggatgcgag     2580

aaggtgttcg aggaacccga ggacttcctg aagcactgcc aggccgatca tctgctggac     2640

gagaaaggca gagcccagtg tctgctccag cgcgagatgg tgcagtctct ggaacagcag     2700

ctggtcctgg aaaaagaaaa gctgagcgcc atgcaggccc acctggccgg aaaaatggcc     2760

ctgacaaagg ccagcagcgt ggcctcttct gataagggca gctgctgcat tgtggccgct     2820

ggatctcagg gacctgtggt tcctgcttgg agcggaccta gagaggcccc tgattctctg     2880

tttgccgtgc ggagacacct gtggggctct cacggcaact ctactttccc cgagttcctg     2940

cacaacatgg actacttcaa gttccacaac atgcggcctc cattcaccta cgccacactg     3000

atcagatggg ccattctgga agcccctgag aagcagagaa ccctgaacga gatctaccac     3060

tggtttaccc ggatgttcgc cttcttccgg aatcaccctg ccacctggaa gaacgccatc     3120

cggcacaatc tgagcctgca caagtgcttc gtgcgcgtgg aatctgagaa aggcgccgtg     3180

tggacagtgg acgagctgga attcagaaag aagagaagcc agcggcctag ccggtgcagc     3240

aatcctacac ctggacct                                                   3258


<210>  80
<211>  1086
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  uDISC_FOXP3cDNA amino acid sequence

<400>  80

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        275                 280                 285             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His Glu Met 
    290                 295                 300                 


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
305                 310                 315                 320 


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
                325                 330                 335     


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
            340                 345                 350         


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
        355                 360                 365             


Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His 
    370                 375                 380                 


Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile 
385                 390                 395                 400 


Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe 
                405                 410                 415     


Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp 
            420                 425                 430         


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
        435                 440                 445             


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
    450                 455                 460                 


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
465                 470                 475                 480 


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
                485                 490                 495     


Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Leu Asn Thr 
            500                 505                 510         


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
545                 550                 555                 560 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
                565                 570                 575     


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
            580                 585                 590         


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
        595                 600                 605             


Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
    610                 615                 620                 


Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly Ala Thr Asn Phe 
625                 630                 635                 640 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                645                 650                 655     


Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu Gly 
            660                 665                 670         


Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala Ser 
        675                 680                 685             


Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg Asp 
    690                 695                 700                 


Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met Pro 
705                 710                 715                 720 


Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala Pro 
                725                 730                 735     


Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu Gln 
            740                 745                 750         


Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His Ala 
        755                 760                 765             


Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met Ile 
    770                 775                 780                 


Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys Ala 
785                 790                 795                 800 


Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val 
                805                 810                 815     


Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala Pro 
            820                 825                 830         


Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro Leu 
        835                 840                 845             


Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe Glu 
    850                 855                 860                 


Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu Asp 
865                 870                 875                 880 


Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser 
                885                 890                 895     


Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln 
            900                 905                 910         


Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala 
        915                 920                 925             


Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly 
    930                 935                 940                 


Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu 
945                 950                 955                 960 


Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe 
                965                 970                 975     


Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg 
            980                 985                 990         


Pro Pro Phe Thr Tyr Ala Thr Leu  Ile Arg Trp Ala Ile  Leu Glu Ala 
        995                 1000                 1005             


Pro Glu  Lys Gln Arg Thr Leu  Asn Glu Ile Tyr His  Trp Phe Thr 
    1010                 1015                 1020             


Arg Met  Phe Ala Phe Phe Arg  Asn His Pro Ala Thr  Trp Lys Asn 
    1025                 1030                 1035             


Ala Ile  Arg His Asn Leu Ser  Leu His Lys Cys Phe  Val Arg Val 
    1040                 1045                 1050             


Glu Ser  Glu Lys Gly Ala Val  Trp Thr Val Asp Glu  Leu Glu Phe 
    1055                 1060                 1065             


Arg Lys  Lys Arg Ser Gln Arg  Pro Ser Arg Cys Ser  Asn Pro Thr 
    1070                 1075                 1080             


Pro Gly  Pro 
    1085     


<210>  81
<211>  4083
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LNGFRe_uDISC _FOXP3cDNA nucleotide sequence  coding sequence only

<400>  81
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

atgggggcag gtgccaccgg acgagccatg gacgggccgc gcctgctgct gttgctgctt      120

ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacacagc      180

ggtgagtgct gcaaagcctg caacctgggc gagggtgtgg cccagccttg tggagccaac      240

cagaccgtgt gtgagccctg cctggacagc gtgacgttct ccgacgtggt gagcgcgacc      300

gagccgtgca agccgtgcac cgagtgcgtg gggctccaga gcatgtcggc gccgtgcgtg      360

gaggccgacg acgccgtgtg ccgctgcgcc tacggctact accaggatga gacgactggg      420

cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtgttctc ctgccaggac      480

aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attccgacga ggccaaccac      540

gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct ccgcgagtgc      600

acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac acggtccaca      660

cccccagagg gctcggacag cacagccccc agcacccagg agcctgaggc acctccagaa      720

caagacctca tagccagcac ggtggcaggt gtggtgacca cagtgatggg cagctcccag      780

cccgtggtga cccgaggcac caccgacaac ctcatccctg tctattgctc catcctggct      840

gctgtggttg tgggtcttgt ggcctacata gccttcaaga ggggcgtgca ggtggagaca      900

atctccccag gcgacggacg cacattccct aagcggggcc agacctgcgt ggtgcactat      960

acaggcatgc tggaggatgg caagaagttt gacagctccc gggatagaaa caagccattc     1020

aagtttatgc tgggcaagca ggaagtgatc agaggctggg aggagggcgt ggcccagatg     1080

tctgtgggcc agagggccaa gctgaccatc agcccagact acgcctatgg agcaacaggc     1140

cacccaggaa tcatcccacc tcacgccacc ctggtgttcg atgtggagct gctgaagctg     1200

ggcgagggag ggtcacctgg atccaacaca tcaaaagaga acccctttct gttcgcattg     1260

gaggccgtag tcatatctgt tggatccatg ggacttatta tctccctgtt gtgtgtgtac     1320

ttctggctgg aacggactat gcccaggatc cccacgctca agaatctgga agatctcgtc     1380

acagaatacc atggtaattt cagcgcctgg agcggagtct ctaagggtct ggccgaatcc     1440

ctccaacccg attattctga acggttgtgc ctcgtatccg aaataccacc aaaaggcggg     1500

gctctgggtg agggcccagg ggcgagtccg tgcaatcaac acagcccgta ttgggcccct     1560

ccttgttata cgttgaagcc cgaaactgga agcggagcta ctaacttcag cctgctgaag     1620

caggctggag acgtggagga gaaccctgga cctatggcac tgcccgtgac cgccctgctg     1680

ctgcctctgg ccctgctgct gcacgcagcc cggcctatcc tgtggcacga gatgtggcac     1740

gagggcctgg aggaggccag caggctgtat tttggcgagc gcaacgtgaa gggcatgttc     1800

gaggtgctgg agcctctgca cgccatgatg gagagaggcc cacagaccct gaaggagaca     1860

tcctttaacc aggcctatgg acgggacctg atggaggcac aggagtggtg cagaaagtac     1920

atgaagtctg gcaatgtgaa ggacctgctg caggcctggg atctgtacta tcacgtgttt     1980

cggagaatct ccaagccagc agctctcggc aaagacacga ttccgtggct tgggcatctg     2040

ctcgttgggc tgagcggtgc gtttggtttc atcatcttgg tctatctctt gatcaattgc     2100

agaaatacag gcccttggct gaaaaaagtg ctcaagtgta atacccccga cccaagcaag     2160

ttcttctccc agctttcttc agagcatgga ggcgatgtgc agaaatggct ctcttcacct     2220

tttccctcct caagcttctc cccgggaggg ctggcgcccg agatttcacc tcttgaggta     2280

cttgaacgag acaaggttac ccaacttctc cttcaacagg ataaggtacc cgaacctgcg     2340

agccttagct tgaatacaga cgcttatctc tcactgcagg aactgcaagg atctggtgct     2400

actaattttt ctcttttgaa gcaagctgga gatgttgaag agaaccccgg tccggagatg     2460

tggcatgagg gtctggaaga agcgtctcga ctgtactttg gtgagcgcaa tgtgaagggc     2520

atgtttgaag tcctcgaacc ccttcatgcc atgatggaac gcggacccca gaccttgaag     2580

gagacaagtt ttaaccaagc ttacggaaga gacctgatgg aagcccagga atggtgcagg     2640

aaatacatga aaagcgggaa tgtgaaggac ttgctccaag cgtgggacct gtactatcat     2700

gtctttaggc gcattagtaa gggaagcgga gcgactaact tcagcctgct taagcaggcc     2760

ggagatgtgg aggaaaaccc tggaccgatg cctaatcctc ggcctggaaa gcctagcgct     2820

ccttctcttg ctctgggacc ttctcctggc gcctctccat cttggagagc cgctcctaaa     2880

gccagcgatc tgctgggagc tagaggacct ggcggcacat ttcagggcag agatcttaga     2940

ggcggagccc acgctagctc ctccagcctt aatcctatgc ctcctagcca gctccagctg     3000

cctacactgc ctctggttat ggtggctcct agcggagcta gactgggccc tctgcctcat     3060

ctgcaagctc tgctgcagga cagaccccac ttcatgcacc agctgagcac cgtggatgcc     3120

cacgcaagaa cacctgtgct gcaggttcac cctctggaat ccccagccat gatcagcctg     3180

acacctccaa caacagccac cggcgtgttc agcctgaaag ccagacctgg actgcctcct     3240

ggcatcaatg tggccagcct ggaatgggtg tccagagaac ctgctctgct gtgcacattc     3300

cccaatccaa gcgctcccag aaaggacagc acactgtctg ccgtgcctca gagcagctat     3360

cccctgcttg ctaacggcgt gtgcaagtgg cctggatgcg agaaggtgtt cgaggaaccc     3420

gaggacttcc tgaagcactg ccaggccgat catctgctgg acgagaaagg cagagcccag     3480

tgtctgctcc agcgcgagat ggtgcagtct ctggaacagc agctggtcct ggaaaaagaa     3540

aagctgagcg ccatgcaggc ccacctggcc ggaaaaatgg ccctgacaaa ggccagcagc     3600

gtggcctctt ctgataaggg cagctgctgc attgtggccg ctggatctca gggacctgtg     3660

gttcctgctt ggagcggacc tagagaggcc cctgattctc tgtttgccgt gcggagacac     3720

ctgtggggct ctcacggcaa ctctactttc cccgagttcc tgcacaacat ggactacttc     3780

aagttccaca acatgcggcc tccattcacc tacgccacac tgatcagatg ggccattctg     3840

gaagcccctg agaagcagag aaccctgaac gagatctacc actggtttac ccggatgttc     3900

gccttcttcc ggaatcaccc tgccacctgg aagaacgcca tccggcacaa tctgagcctg     3960

cacaagtgct tcgtgcgcgt ggaatctgag aaaggcgccg tgtggacagt ggacgagctg     4020

gaattcagaa agaagagaag ccagcggcct agccggtgca gcaatcctac acctggacct     4080

tga                                                                   4083


<210>  82
<211>  1360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  LNGFRe_uDISC_FOXP3cDNA amino acid sequence

<400>  82

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly 
            20                  25                  30          


Pro Arg Leu Leu Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala 
        35                  40                  45              


Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
    50                  55                  60                  


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
65                  70                  75                  80  


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
                85                  90                  95      


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
            100                 105                 110         


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
        115                 120                 125             


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
    130                 135                 140                 


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
                165                 170                 175     


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
            180                 185                 190         


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
        195                 200                 205             


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
    210                 215                 220                 


Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu 
225                 230                 235                 240 


Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met 
                245                 250                 255     


Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile 
            260                 265                 270         


Pro Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala 
        275                 280                 285             


Tyr Ile Ala Phe Lys Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
    290                 295                 300                 


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
305                 310                 315                 320 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
                325                 330                 335     


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
            340                 345                 350         


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
        355                 360                 365             


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
    370                 375                 380                 


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
385                 390                 395                 400 


Gly Glu Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                405                 410                 415     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            420                 425                 430         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        435                 440                 445             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    450                 455                 460                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
465                 470                 475                 480 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                485                 490                 495     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            500                 505                 510         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        515                 520                 525             


Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    530                 535                 540                 


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
545                 550                 555                 560 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His 
                565                 570                 575     


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
            580                 585                 590         


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
        595                 600                 605             


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
    610                 615                 620                 


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
625                 630                 635                 640 


Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
                645                 650                 655     


Tyr His Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp 
            660                 665                 670         


Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe 
        675                 680                 685             


Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly 
    690                 695                 700                 


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
705                 710                 715                 720 


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
                725                 730                 735     


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
            740                 745                 750         


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
        755                 760                 765             


Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Leu 
    770                 775                 780                 


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Ser Gly Ala 
785                 790                 795                 800 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                805                 810                 815     


Gly Pro Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
            820                 825                 830         


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
        835                 840                 845             


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
    850                 855                 860                 


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
865                 870                 875                 880 


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp 
                885                 890                 895     


Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly Ala Thr 
            900                 905                 910         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        915                 920                 925             


Pro Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala 
    930                 935                 940                 


Leu Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys 
945                 950                 955                 960 


Ala Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly 
                965                 970                 975     


Arg Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro 
            980                 985                 990         


Met Pro Pro Ser Gln Leu Gln Leu  Pro Thr Leu Pro Leu  Val Met Val 
        995                 1000                 1005             


Ala Pro  Ser Gly Ala Arg Leu  Gly Pro Leu Pro His  Leu Gln Ala 
    1010                 1015                 1020             


Leu Leu  Gln Asp Arg Pro His  Phe Met His Gln Leu  Ser Thr Val 
    1025                 1030                 1035             


Asp Ala  His Ala Arg Thr Pro  Val Leu Gln Val His  Pro Leu Glu 
    1040                 1045                 1050             


Ser Pro  Ala Met Ile Ser Leu  Thr Pro Pro Thr Thr  Ala Thr Gly 
    1055                 1060                 1065             


Val Phe  Ser Leu Lys Ala Arg  Pro Gly Leu Pro Pro  Gly Ile Asn 
    1070                 1075                 1080             


Val Ala  Ser Leu Glu Trp Val  Ser Arg Glu Pro Ala  Leu Leu Cys 
    1085                 1090                 1095             


Thr Phe  Pro Asn Pro Ser Ala  Pro Arg Lys Asp Ser  Thr Leu Ser 
    1100                 1105                 1110             


Ala Val  Pro Gln Ser Ser Tyr  Pro Leu Leu Ala Asn  Gly Val Cys 
    1115                 1120                 1125             


Lys Trp  Pro Gly Cys Glu Lys  Val Phe Glu Glu Pro  Glu Asp Phe 
    1130                 1135                 1140             


Leu Lys  His Cys Gln Ala Asp  His Leu Leu Asp Glu  Lys Gly Arg 
    1145                 1150                 1155             


Ala Gln  Cys Leu Leu Gln Arg  Glu Met Val Gln Ser  Leu Glu Gln 
    1160                 1165                 1170             


Gln Leu  Val Leu Glu Lys Glu  Lys Leu Ser Ala Met  Gln Ala His 
    1175                 1180                 1185             


Leu Ala  Gly Lys Met Ala Leu  Thr Lys Ala Ser Ser  Val Ala Ser 
    1190                 1195                 1200             


Ser Asp  Lys Gly Ser Cys Cys  Ile Val Ala Ala Gly  Ser Gln Gly 
    1205                 1210                 1215             


Pro Val  Val Pro Ala Trp Ser  Gly Pro Arg Glu Ala  Pro Asp Ser 
    1220                 1225                 1230             


Leu Phe  Ala Val Arg Arg His  Leu Trp Gly Ser His  Gly Asn Ser 
    1235                 1240                 1245             


Thr Phe  Pro Glu Phe Leu His  Asn Met Asp Tyr Phe  Lys Phe His 
    1250                 1255                 1260             


Asn Met  Arg Pro Pro Phe Thr  Tyr Ala Thr Leu Ile  Arg Trp Ala 
    1265                 1270                 1275             


Ile Leu  Glu Ala Pro Glu Lys  Gln Arg Thr Leu Asn  Glu Ile Tyr 
    1280                 1285                 1290             


His Trp  Phe Thr Arg Met Phe  Ala Phe Phe Arg Asn  His Pro Ala 
    1295                 1300                 1305             


Thr Trp  Lys Asn Ala Ile Arg  His Asn Leu Ser Leu  His Lys Cys 
    1310                 1315                 1320             


Phe Val  Arg Val Glu Ser Glu  Lys Gly Ala Val Trp  Thr Val Asp 
    1325                 1330                 1335             


Glu Leu  Glu Phe Arg Lys Lys  Arg Ser Gln Arg Pro  Ser Arg Cys 
    1340                 1345                 1350             


Ser Asn  Pro Thr Pro Gly Pro  
    1355                 1360 


<210>  83
<211>  2463
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DISC nucleotide sequence  coding sequence only codon optimized 

<400>  83
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagctact      780

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatggcactg      840

cccgtgaccg ccctgctgct gcctctggcc ctgctgctgc acgcagcccg gcctatcctg      900

tggcacgaga tgtggcacga gggcctggag gaggccagca ggctgtattt tggcgagcgc      960

aacgtgaagg gcatgttcga ggtgctggag cctctgcacg ccatgatgga gagaggccca     1020

cagaccctga aggagacatc ctttaaccag gcctatggac gggacctgat ggaggcacag     1080

gagtggtgca gaaagtacat gaagtctggc aatgtgaagg acctgctgca ggcctgggat     1140

ctgtactatc acgtgtttcg gagaatctcc aagccagcag ctctcggcaa agacacgatt     1200

ccgtggcttg ggcatctgct cgttgggctg agcggtgcgt ttggtttcat catcttggtc     1260

tatctcttga tcaattgcag aaatacaggc ccttggctga aaaaagtgct caagtgtaat     1320

acccccgacc caagcaagtt cttctcccag ctttcttcag agcatggagg cgatgtgcag     1380

aaatggctct cttcaccttt tccctcctca agcttctccc cgggagggct ggcgcccgag     1440

atttcacctc ttgaggtact tgaacgagac aaggttaccc aacttctcct tcaacaggat     1500

aaggtacccg aacctgcgag ccttagctcc aaccactctc ttacgagctg cttcaccaat     1560

cagggatact tctttttcca ccttcccgat gcgctggaaa tcgaagcttg tcaagtttac     1620

tttacctatg atccatatag cgaggaagat cccgacgaag gagtcgccgg tgcgcccacg     1680

ggttcctcac cccaacctct ccagcctctc tcaggagaag atgatgctta ttgcactttt     1740

cccagtagag acgatctcct cctcttttct ccatctcttt tggggggacc ttccccccct     1800

tctacggcac ctggcgggtc tggtgctggc gaggagcgga tgccgccgtc cctccaggag     1860

cgagtaccac gagattggga tccccagcca cttggacccc ccacccccgg cgtacctgac     1920

cttgtcgatt ttcaacctcc ccctgaattg gtgctgcgag aggctgggga ggaagttccg     1980

gacgctgggc cgagggaggg cgtgtccttt ccatggagta ggcctccagg tcaaggcgag     2040

tttagggctc tcaacgcgcg gctgccgttg aatacagacg cttatctctc actgcaggaa     2100

ctgcaaggtc aggacccaac acatcttgta ggatctggtg ctactaattt ttctcttttg     2160

aagcaagctg gagatgttga agagaacccc ggtccggaga tgtggcatga gggtctggaa     2220

gaagcgtctc gactgtactt tggtgagcgc aatgtgaagg gcatgtttga agtcctcgaa     2280

ccccttcatg ccatgatgga acgcggaccc cagaccttga aggagacaag ttttaaccaa     2340

gcttacggaa gagacctgat ggaagcccag gaatggtgca ggaaatacat gaaaagcggg     2400

aatgtgaagg acttgctcca agcgtgggac ctgtactatc atgtctttag gcgcattagt     2460

aag                                                                   2463


<210>  84
<211>  821
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  DISC amino acid sequence

<400>  84

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        275                 280                 285             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His Glu Met 
    290                 295                 300                 


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
305                 310                 315                 320 


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
                325                 330                 335     


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
            340                 345                 350         


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
        355                 360                 365             


Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His 
    370                 375                 380                 


Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile 
385                 390                 395                 400 


Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe 
                405                 410                 415     


Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp 
            420                 425                 430         


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
        435                 440                 445             


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
    450                 455                 460                 


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
465                 470                 475                 480 


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
                485                 490                 495     


Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His 
            500                 505                 510         


Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu 
        515                 520                 525             


Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp 
    530                 535                 540                 


Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr 
545                 550                 555                 560 


Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala 
                565                 570                 575     


Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser 
            580                 585                 590         


Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly 
        595                 600                 605             


Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg 
    610                 615                 620                 


Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp 
625                 630                 635                 640 


Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly 
                645                 650                 655     


Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp 
            660                 665                 670         


Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu 
        675                 680                 685             


Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln 
    690                 695                 700                 


Asp Pro Thr His Leu Val Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
705                 710                 715                 720 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Met Trp His 
                725                 730                 735     


Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
            740                 745                 750         


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
        755                 760                 765             


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
    770                 775                 780                 


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
785                 790                 795                 800 


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
                805                 810                 815     


Arg Arg Ile Ser Lys 
            820     


<210>  85
<211>  1899
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  uDISC nucleotide sequence  coding sequence only codon optimized 

<400>  85
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagctact      780

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatggcactg      840

cccgtgaccg ccctgctgct gcctctggcc ctgctgctgc acgcagcccg gcctatcctg      900

tggcacgaga tgtggcacga gggcctggag gaggccagca ggctgtattt tggcgagcgc      960

aacgtgaagg gcatgttcga ggtgctggag cctctgcacg ccatgatgga gagaggccca     1020

cagaccctga aggagacatc ctttaaccag gcctatggac gggacctgat ggaggcacag     1080

gagtggtgca gaaagtacat gaagtctggc aatgtgaagg acctgctgca ggcctgggat     1140

ctgtactatc acgtgtttcg gagaatctcc aagccagcag ctctcggcaa agacacgatt     1200

ccgtggcttg ggcatctgct cgttgggctg agcggtgcgt ttggtttcat catcttggtc     1260

tatctcttga tcaattgcag aaatacaggc ccttggctga aaaaagtgct caagtgtaat     1320

acccccgacc caagcaagtt cttctcccag ctttcttcag agcatggagg cgatgtgcag     1380

aaatggctct cttcaccttt tccctcctca agcttctccc cgggagggct ggcgcccgag     1440

atttcacctc ttgaggtact tgaacgagac aaggttaccc aacttctcct tcaacaggat     1500

aaggtacccg aacctgcgag ccttagcttg aatacagacg cttatctctc actgcaggaa     1560

ctgcaaggat ctggtgctac taatttttct cttttgaagc aagctggaga tgttgaagag     1620

aaccccggtc cggagatgtg gcatgagggt ctggaagaag cgtctcgact gtactttggt     1680

gagcgcaatg tgaagggcat gtttgaagtc ctcgaacccc ttcatgccat gatggaacgc     1740

ggaccccaga ccttgaagga gacaagtttt aaccaagctt acggaagaga cctgatggaa     1800

gcccaggaat ggtgcaggaa atacatgaaa agcgggaatg tgaaggactt gctccaagcg     1860

tgggacctgt actatcatgt ctttaggcgc attagtaag                            1899


<210>  86
<211>  633
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  uDISC amino acid sequence

<400>  86

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        275                 280                 285             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His Glu Met 
    290                 295                 300                 


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
305                 310                 315                 320 


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
                325                 330                 335     


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
            340                 345                 350         


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
        355                 360                 365             


Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His 
    370                 375                 380                 


Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile 
385                 390                 395                 400 


Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe 
                405                 410                 415     


Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp 
            420                 425                 430         


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
        435                 440                 445             


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
    450                 455                 460                 


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
465                 470                 475                 480 


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
                485                 490                 495     


Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Leu Asn Thr 
            500                 505                 510         


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
545                 550                 555                 560 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
                565                 570                 575     


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
            580                 585                 590         


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
        595                 600                 605             


Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
    610                 615                 620                 


Tyr His Val Phe Arg Arg Ile Ser Lys 
625                 630             


<210>  87
<211>  1632
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCbeta_DN nucleotide sequence  coding sequence only 

<400>  87
atggcactgc ccgtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcccgg       60

cctatcctgt ggcacgagat gtggcacgag ggcctggagg aggccagcag gctgtatttt      120

ggcgagcgca acgtgaaggg catgttcgag gtgctggagc ctctgcacgc catgatggag      180

agaggcccac agaccctgaa ggagacatcc tttaaccagg cctatggacg ggacctgatg      240

gaggcacagg agtggtgcag aaagtacatg aagtctggca atgtgaagga cctgctgcag      300

gcctgggatc tgtactatca cgtgtttcgg agaatctcca agccagcagc tctcggcaaa      360

gacacgattc cgtggcttgg gcatctgctc gttgggctga gcggtgcgtt tggtttcatc      420

atcttggtct atctcttgat caattgcaga aatacaggcc cttggctgaa aaaagtgctc      480

aagtgtaata cccccgaccc aagcaagttc ttctcccagc tttcttcaga gcatggaggc      540

gatgtgcaga aatggctctc ttcacctttt ccctcctcaa gcttctcccc gggagggctg      600

gcgcccgaga tttcacctct tgaggtactt gaacgagaca aggttaccca acttctcctt      660

caacaggata aggtacccga acctgcgagc cttagctcca accactctct tacgagctgc      720

ttcaccaatc agggatactt ctttttccac cttcccgatg cgctggaaat cgaagcttgt      780

caagtttact ttacctatga tccatatagc gaggaagatc ccgacgaagg agtcgccggt      840

gcgcccacgg gttcctcacc ccaacctctc cagcctctct caggagaaga tgatgcttat      900

tgcacttttc ccagtagaga cgatctcctc ctcttttctc catctctttt ggggggacct      960

tccccccctt ctacggcacc tggcgggtct ggtgctggcg aggagcggat gccgccgtcc     1020

ctccaggagc gagtaccacg agattgggat ccccagccac ttggaccccc cacccccggc     1080

gtacctgacc ttgtcgattt tcaacctccc cctgaattgg tgctgcgaga ggctggggag     1140

gaagttccgg acgctgggcc gagggagggc gtgtcctttc catggagtag gcctccaggt     1200

caaggcgagt ttagggctct caacgcgcgg ctgccgttga atacagacgc ttatctctca     1260

ctgcaggaac tgcaaggtca ggacccaaca catcttgtag gatctggtgc tactaatttt     1320

tctcttttga agcaagctgg agatgttgaa gagaaccccg gtccggagat gtggcatgag     1380

ggtctggaag aagcgtctcg actgtacttt ggtgagcgca atgtgaaggg catgtttgaa     1440

gtcctcgaac cccttcatgc catgatggaa cgcggacccc agaccttgaa ggagacaagt     1500

tttaaccaag cttacggaag agacctgatg gaagcccagg aatggtgcag gaaatacatg     1560

aaaagcggga atgtgaagga cttgctccaa gcgtgggacc tgtactatca tgtctttagg     1620

cgcattagta ag                                                         1632


<210>  88
<211>  544
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  CISCbeta_DN amino acid sequence

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His 
        115                 120                 125             


Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr 
    130                 135                 140                 


Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu 
145                 150                 155                 160 


Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser 
                165                 170                 175     


Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser 
            180                 185                 190         


Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu 
        195                 200                 205             


Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys 
    210                 215                 220                 


Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys 
225                 230                 235                 240 


Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu 
                245                 250                 255     


Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu 
            260                 265                 270         


Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln 
        275                 280                 285             


Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro 
    290                 295                 300                 


Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg 
                325                 330                 335     


Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln 
            340                 345                 350         


Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln 
        355                 360                 365             


Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp 
    370                 375                 380                 


Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly 
385                 390                 395                 400 


Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp 
                405                 410                 415     


Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu 
            420                 425                 430         


Val Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        435                 440                 445             


Val Glu Glu Asn Pro Gly Pro Glu Met Trp His Glu Gly Leu Glu Glu 
    450                 455                 460                 


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
465                 470                 475                 480 


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
                485                 490                 495     


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
            500                 505                 510         


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
        515                 520                 525             


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
    530                 535                 540                 


<210>  89
<211>  3015
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCgamma_FOXP3cDNA_LNGFR nucleotide sequence  coding sequence 
       only codon optimized

<400>  89
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagcgact      780

aacttcagcc tgcttaagca ggccggagat gtggaggaaa accctggacc gatgcctaat      840

cctcggcctg gaaagcctag cgctccttct cttgctctgg gaccttctcc tggcgcctct      900

ccatcttgga gagccgctcc taaagccagc gatctgctgg gagctagagg acctggcggc      960

acatttcagg gcagagatct tagaggcgga gcccacgcta gctcctccag ccttaatcct     1020

atgcctccta gccagctcca gctgcctaca ctgcctctgg ttatggtggc tcctagcgga     1080

gctagactgg gccctctgcc tcatctgcaa gctctgctgc aggacagacc ccacttcatg     1140

caccagctga gcaccgtgga tgcccacgca agaacacctg tgctgcaggt tcaccctctg     1200

gaatccccag ccatgatcag cctgacacct ccaacaacag ccaccggcgt gttcagcctg     1260

aaagccagac ctggactgcc tcctggcatc aatgtggcca gcctggaatg ggtgtccaga     1320

gaacctgctc tgctgtgcac attccccaat ccaagcgctc ccagaaagga cagcacactg     1380

tctgccgtgc ctcagagcag ctatcccctg cttgctaacg gcgtgtgcaa gtggcctgga     1440

tgcgagaagg tgttcgagga acccgaggac ttcctgaagc actgccaggc cgatcatctg     1500

ctggacgaga aaggcagagc ccagtgtctg ctccagcgcg agatggtgca gtctctggaa     1560

cagcagctgg tcctggaaaa agaaaagctg agcgccatgc aggcccacct ggccggaaaa     1620

atggccctga caaaggccag cagcgtggcc tcttctgata agggcagctg ctgcattgtg     1680

gccgctggat ctcagggacc tgtggttcct gcttggagcg gacctagaga ggcccctgat     1740

tctctgtttg ccgtgcggag acacctgtgg ggctctcacg gcaactctac tttccccgag     1800

ttcctgcaca acatggacta cttcaagttc cacaacatgc ggcctccatt cacctacgcc     1860

acactgatca gatgggccat tctggaagcc cctgagaagc agagaaccct gaacgagatc     1920

taccactggt ttacccggat gttcgccttc ttccggaatc accctgccac ctggaagaac     1980

gccatccggc acaatctgag cctgcacaag tgcttcgtgc gcgtggaatc tgagaaaggc     2040

gccgtgtgga cagtggacga gctggaattc agaaagaaga gaagccagcg gcctagccgg     2100

tgcagcaatc ctacacctgg acctggaagc ggagcgacta acttcagcct gctgaagcag     2160

gccggagatg tggaggaaaa ccctggaccg atgggggcag gtgccaccgg acgagccatg     2220

gacgggccgc gcctgctgct gttgctgctt ctgggggtgt cccttggagg tgccaaggag     2280

gcatgcccca caggcctgta cacacacagc ggtgagtgct gcaaagcctg caacctgggc     2340

gagggtgtgg cccagccttg tggagccaac cagaccgtgt gtgagccctg cctggacagc     2400

gtgacgttct ccgacgtggt gagcgcgacc gagccgtgca agccgtgcac cgagtgcgtg     2460

gggctccaga gcatgtcggc gccgtgcgtg gaggccgacg acgccgtgtg ccgctgcgcc     2520

tacggctact accaggatga gacgactggg cgctgcgagg cgtgccgcgt gtgcgaggcg     2580

ggctcgggcc tcgtgttctc ctgccaggac aagcagaaca ccgtgtgcga ggagtgcccc     2640

gacggcacgt attccgacga ggccaaccac gtggacccgt gcctgccctg caccgtgtgc     2700

gaggacaccg agcgccagct ccgcgagtgc acacgctggg ccgacgccga gtgcgaggag     2760

atccctggcc gttggattac acggtccaca cccccagagg gctcggacag cacagccccc     2820

agcacccagg agcctgaggc acctccagaa caagacctca tagccagcac ggtggcaggt     2880

gtggtgacca cagtgatggg cagctcccag cccgtggtga cccgaggcac caccgacaac     2940

ctcatccctg tctattgctc catcctggct gctgtggttg tgggtcttgt ggcctacata     3000

gccttcaaga ggtga                                                      3015


<210>  90
<211>  1004
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  CISCgamma_FOXP3cDNA_LNGFR amino acid sequence

<400>  90

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala 
        275                 280                 285             


Pro Ser Leu Ala Leu Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg 
    290                 295                 300                 


Ala Ala Pro Lys Ala Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly 
305                 310                 315                 320 


Thr Phe Gln Gly Arg Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser 
                325                 330                 335     


Ser Leu Asn Pro Met Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro 
            340                 345                 350         


Leu Val Met Val Ala Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His 
        355                 360                 365             


Leu Gln Ala Leu Leu Gln Asp Arg Pro His Phe Met His Gln Leu Ser 
    370                 375                 380                 


Thr Val Asp Ala His Ala Arg Thr Pro Val Leu Gln Val His Pro Leu 
385                 390                 395                 400 


Glu Ser Pro Ala Met Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly 
                405                 410                 415     


Val Phe Ser Leu Lys Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val 
            420                 425                 430         


Ala Ser Leu Glu Trp Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe 
        435                 440                 445             


Pro Asn Pro Ser Ala Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro 
    450                 455                 460                 


Gln Ser Ser Tyr Pro Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly 
465                 470                 475                 480 


Cys Glu Lys Val Phe Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln 
                485                 490                 495     


Ala Asp His Leu Leu Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln 
            500                 505                 510         


Arg Glu Met Val Gln Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu 
        515                 520                 525             


Lys Leu Ser Ala Met Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr 
    530                 535                 540                 


Lys Ala Ser Ser Val Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val 
545                 550                 555                 560 


Ala Ala Gly Ser Gln Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg 
                565                 570                 575     


Glu Ala Pro Asp Ser Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser 
            580                 585                 590         


His Gly Asn Ser Thr Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe 
        595                 600                 605             


Lys Phe His Asn Met Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg 
    610                 615                 620                 


Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile 
625                 630                 635                 640 


Tyr His Trp Phe Thr Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala 
                645                 650                 655     


Thr Trp Lys Asn Ala Ile Arg His Asn Leu Ser Leu His Lys Cys Phe 
            660                 665                 670         


Val Arg Val Glu Ser Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu 
        675                 680                 685             


Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro 
    690                 695                 700                 


Thr Pro Gly Pro Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
705                 710                 715                 720 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ala Gly Ala Thr 
                725                 730                 735     


Gly Arg Ala Met Asp Gly Pro Arg Leu Leu Leu Leu Leu Leu Leu Gly 
            740                 745                 750         


Val Ser Leu Gly Gly Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr 
        755                 760                 765             


His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala 
    770                 775                 780                 


Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser 
785                 790                 795                 800 


Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys 
                805                 810                 815     


Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala 
            820                 825                 830         


Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr 
        835                 840                 845             


Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu 
    850                 855                 860                 


Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu Cys Pro 
865                 870                 875                 880 


Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro 
                885                 890                 895     


Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg 
            900                 905                 910         


Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg 
        915                 920                 925             


Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu 
    930                 935                 940                 


Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly 
945                 950                 955                 960 


Val Val Thr Thr Val Met Gly Ser Ser Gln Pro Val Val Thr Arg Gly 
                965                 970                 975     


Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys Ser Ile Leu Ala Ala Val 
            980                 985                 990         


Val Val Gly Leu Val Ala Tyr Ile  Ala Phe Lys Arg 
        995                 1000                 


<210>  91
<211>  3015
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCgamma_LNGFR_FOXP3cDNA nucleotide sequence  coding sequence 
       only codon optimized

<400>  91
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagcgact      780

aacttcagcc tgcttaagca ggccggagat gtggaggaaa accctggacc gatgggggca      840

ggtgccaccg gacgagccat ggacgggccg cgcctgctgc tgttgctgct tctgggggtg      900

tcccttggag gtgccaagga ggcatgcccc acaggcctgt acacacacag cggtgagtgc      960

tgcaaagcct gcaacctggg cgagggtgtg gcccagcctt gtggagccaa ccagaccgtg     1020

tgtgagccct gcctggacag cgtgacgttc tccgacgtgg tgagcgcgac cgagccgtgc     1080

aagccgtgca ccgagtgcgt ggggctccag agcatgtcgg cgccgtgcgt ggaggccgac     1140

gacgccgtgt gccgctgcgc ctacggctac taccaggatg agacgactgg gcgctgcgag     1200

gcgtgccgcg tgtgcgaggc gggctcgggc ctcgtgttct cctgccagga caagcagaac     1260

accgtgtgcg aggagtgccc cgacggcacg tattccgacg aggccaacca cgtggacccg     1320

tgcctgccct gcaccgtgtg cgaggacacc gagcgccagc tccgcgagtg cacacgctgg     1380

gccgacgccg agtgcgagga gatccctggc cgttggatta cacggtccac acccccagag     1440

ggctcggaca gcacagcccc cagcacccag gagcctgagg cacctccaga acaagacctc     1500

atagccagca cggtggcagg tgtggtgacc acagtgatgg gcagctccca gcccgtggtg     1560

acccgaggca ccaccgacaa cctcatccct gtctattgct ccatcctggc tgctgtggtt     1620

gtgggtcttg tggcctacat agccttcaag aggggaagcg gagcgactaa cttcagcctg     1680

ctgaagcagg ccggagatgt ggaggaaaac cctggaccga tgcctaatcc tcggcctgga     1740

aagcctagcg ctccttctct tgctctggga ccttctcctg gcgcctctcc atcttggaga     1800

gccgctccta aagccagcga tctgctggga gctagaggac ctggcggcac atttcagggc     1860

agagatctta gaggcggagc ccacgctagc tcctccagcc ttaatcctat gcctcctagc     1920

cagctccagc tgcctacact gcctctggtt atggtggctc ctagcggagc tagactgggc     1980

cctctgcctc atctgcaagc tctgctgcag gacagacccc acttcatgca ccagctgagc     2040

accgtggatg cccacgcaag aacacctgtg ctgcaggttc accctctgga atccccagcc     2100

atgatcagcc tgacacctcc aacaacagcc accggcgtgt tcagcctgaa agccagacct     2160

ggactgcctc ctggcatcaa tgtggccagc ctggaatggg tgtccagaga acctgctctg     2220

ctgtgcacat tccccaatcc aagcgctccc agaaaggaca gcacactgtc tgccgtgcct     2280

cagagcagct atcccctgct tgctaacggc gtgtgcaagt ggcctggatg cgagaaggtg     2340

ttcgaggaac ccgaggactt cctgaagcac tgccaggccg atcatctgct ggacgagaaa     2400

ggcagagccc agtgtctgct ccagcgcgag atggtgcagt ctctggaaca gcagctggtc     2460

ctggaaaaag aaaagctgag cgccatgcag gcccacctgg ccggaaaaat ggccctgaca     2520

aaggccagca gcgtggcctc ttctgataag ggcagctgct gcattgtggc cgctggatct     2580

cagggacctg tggttcctgc ttggagcgga cctagagagg cccctgattc tctgtttgcc     2640

gtgcggagac acctgtgggg ctctcacggc aactctactt tccccgagtt cctgcacaac     2700

atggactact tcaagttcca caacatgcgg cctccattca cctacgccac actgatcaga     2760

tgggccattc tggaagcccc tgagaagcag agaaccctga acgagatcta ccactggttt     2820

acccggatgt tcgccttctt ccggaatcac cctgccacct ggaagaacgc catccggcac     2880

aatctgagcc tgcacaagtg cttcgtgcgc gtggaatctg agaaaggcgc cgtgtggaca     2940

gtggacgagc tggaattcag aaagaagaga agccagcggc ctagccggtg cagcaatcct     3000

acacctggac cttga                                                      3015


<210>  92
<211>  3015
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCgamma_LNGFR_FOXP3cDNA amino acid sequence

<400>  92
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagcgact      780

aacttcagcc tgcttaagca ggccggagat gtggaggaaa accctggacc gatgggggca      840

ggtgccaccg gacgagccat ggacgggccg cgcctgctgc tgttgctgct tctgggggtg      900

tcccttggag gtgccaagga ggcatgcccc acaggcctgt acacacacag cggtgagtgc      960

tgcaaagcct gcaacctggg cgagggtgtg gcccagcctt gtggagccaa ccagaccgtg     1020

tgtgagccct gcctggacag cgtgacgttc tccgacgtgg tgagcgcgac cgagccgtgc     1080

aagccgtgca ccgagtgcgt ggggctccag agcatgtcgg cgccgtgcgt ggaggccgac     1140

gacgccgtgt gccgctgcgc ctacggctac taccaggatg agacgactgg gcgctgcgag     1200

gcgtgccgcg tgtgcgaggc gggctcgggc ctcgtgttct cctgccagga caagcagaac     1260

accgtgtgcg aggagtgccc cgacggcacg tattccgacg aggccaacca cgtggacccg     1320

tgcctgccct gcaccgtgtg cgaggacacc gagcgccagc tccgcgagtg cacacgctgg     1380

gccgacgccg agtgcgagga gatccctggc cgttggatta cacggtccac acccccagag     1440

ggctcggaca gcacagcccc cagcacccag gagcctgagg cacctccaga acaagacctc     1500

atagccagca cggtggcagg tgtggtgacc acagtgatgg gcagctccca gcccgtggtg     1560

acccgaggca ccaccgacaa cctcatccct gtctattgct ccatcctggc tgctgtggtt     1620

gtgggtcttg tggcctacat agccttcaag aggggaagcg gagcgactaa cttcagcctg     1680

ctgaagcagg ccggagatgt ggaggaaaac cctggaccga tgcctaatcc tcggcctgga     1740

aagcctagcg ctccttctct tgctctggga ccttctcctg gcgcctctcc atcttggaga     1800

gccgctccta aagccagcga tctgctggga gctagaggac ctggcggcac atttcagggc     1860

agagatctta gaggcggagc ccacgctagc tcctccagcc ttaatcctat gcctcctagc     1920

cagctccagc tgcctacact gcctctggtt atggtggctc ctagcggagc tagactgggc     1980

cctctgcctc atctgcaagc tctgctgcag gacagacccc acttcatgca ccagctgagc     2040

accgtggatg cccacgcaag aacacctgtg ctgcaggttc accctctgga atccccagcc     2100

atgatcagcc tgacacctcc aacaacagcc accggcgtgt tcagcctgaa agccagacct     2160

ggactgcctc ctggcatcaa tgtggccagc ctggaatggg tgtccagaga acctgctctg     2220

ctgtgcacat tccccaatcc aagcgctccc agaaaggaca gcacactgtc tgccgtgcct     2280

cagagcagct atcccctgct tgctaacggc gtgtgcaagt ggcctggatg cgagaaggtg     2340

ttcgaggaac ccgaggactt cctgaagcac tgccaggccg atcatctgct ggacgagaaa     2400

ggcagagccc agtgtctgct ccagcgcgag atggtgcagt ctctggaaca gcagctggtc     2460

ctggaaaaag aaaagctgag cgccatgcag gcccacctgg ccggaaaaat ggccctgaca     2520

aaggccagca gcgtggcctc ttctgataag ggcagctgct gcattgtggc cgctggatct     2580

cagggacctg tggttcctgc ttggagcgga cctagagagg cccctgattc tctgtttgcc     2640

gtgcggagac acctgtgggg ctctcacggc aactctactt tccccgagtt cctgcacaac     2700

atggactact tcaagttcca caacatgcgg cctccattca cctacgccac actgatcaga     2760

tgggccattc tggaagcccc tgagaagcag agaaccctga acgagatcta ccactggttt     2820

acccggatgt tcgccttctt ccggaatcac cctgccacct ggaagaacgc catccggcac     2880

aatctgagcc tgcacaagtg cttcgtgcgc gtggaatctg agaaaggcgc cgtgtggaca     2940

gtggacgagc tggaattcag aaagaagaga agccagcggc ctagccggtg cagcaatcct     3000

acacctggac cttga                                                      3015


<210>  93
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC amino acid sequence

<400>  93

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  94
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
        115                 120                 125             


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
    130                 135                 140                 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
145                 150                 155                 160 


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
                165                 170                 175     


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
            180                 185                 190         


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
        195                 200                 205             


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
    210                 215                 220                 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
225                 230                 235                 240 


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
                245                 250                 255     


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
            260                 265                 270         


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
        275                 280                 285             


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
    290                 295                 300                 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
305                 310                 315                 320 


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
                325                 330                 335     


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
            340                 345                 350         


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
        355                 360                 365             


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
    370                 375                 380                 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
385                 390                 395                 400 


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
                405                 410                 415     


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            420                 425                 


<210>  95
<211>  352
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC

<400>  95

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Gly Ser Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr 
    130                 135                 140                 


Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg 
145                 150                 155                 160 


Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp 
                165                 170                 175     


Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser 
            180                 185                 190         


Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser 
        195                 200                 205             


Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser 
    210                 215                 220                 


His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu 
225                 230                 235                 240 


Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile 
                245                 250                 255     


Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg 
            260                 265                 270         


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
        275                 280                 285             


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
    290                 295                 300                 


Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro 
305                 310                 315                 320 


Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln 
                325                 330                 335     


His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345                 350         


<210>  96
<211>  543
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC

<400>  96

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Gly Ser Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
        115                 120                 125             


Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser 
    130                 135                 140                 


Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
145                 150                 155                 160 


Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                165                 170                 175     


Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr 
            180                 185                 190         


Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
        195                 200                 205             


Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
    210                 215                 220                 


Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu 
225                 230                 235                 240 


Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu 
                245                 250                 255     


Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys 
            260                 265                 270         


Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Gln Leu Ser Ser Glu His 
        275                 280                 285             


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
    290                 295                 300                 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
305                 310                 315                 320 


Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro 
                325                 330                 335     


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
            340                 345                 350         


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
        355                 360                 365             


Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
    370                 375                 380                 


Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu 
385                 390                 395                 400 


Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg 
                405                 410                 415     


Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro 
            420                 425                 430         


Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro 
        435                 440                 445             


Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu 
    450                 455                 460                 


Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro 
465                 470                 475                 480 


Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly 
                485                 490                 495     


Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly 
            500                 505                 510         


Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr 
        515                 520                 525             


Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    530                 535                 540             


<210>  97
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC

<400>  97

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys 
    130                 135                 140                 


Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn 
145                 150                 155                 160 


His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser 
                165                 170                 175     


Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser 
            180                 185                 190         


Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn 
        195                 200                 205             


Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile 
    210                 215                 220                 


His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu 
225                 230                 235                 240 


Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu 
                245                 250                 255     


Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr 
            260                 265                 270         


Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser 
        275                 280                 285             


Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp 
    290                 295                 300                 


Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly 
305                 310                 315                 320 


Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro 
                325                 330                 335     


Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345                 


<210>  98
<211>  541
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC

<400>  98

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
        115                 120                 125             


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
    130                 135                 140                 


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
145                 150                 155                 160 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
                165                 170                 175     


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
            180                 185                 190         


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
        195                 200                 205             


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
    210                 215                 220                 


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
225                 230                 235                 240 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
                245                 250                 255     


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
            260                 265                 270         


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
        275                 280                 285             


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
    290                 295                 300                 


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
305                 310                 315                 320 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
                325                 330                 335     


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
            340                 345                 350         


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
        355                 360                 365             


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
    370                 375                 380                 


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
                405                 410                 415     


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
            420                 425                 430         


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
        435                 440                 445             


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
    450                 455                 460                 


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
465                 470                 475                 480 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
                485                 490                 495     


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
            500                 505                 510         


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
        515                 520                 525             


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    530                 535                 540     


<210>  99
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC

<400>  99

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  100
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC

<400>  100

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Trp Leu Gly His Leu Leu Val Gly Leu Ser 
65                  70                  75                  80  


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
                85                  90                  95      


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
            100                 105                 110         


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
        115                 120                 125             


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
    130                 135                 140                 


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
145                 150                 155                 160 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
                165                 170                 175     


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
            180                 185                 190         


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
        195                 200                 205             


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
    210                 215                 220                 


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
225                 230                 235                 240 


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
                245                 250                 255     


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
            260                 265                 270         


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
        275                 280                 285             


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
    290                 295                 300                 


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
305                 310                 315                 320 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
                325                 330                 335     


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
            340                 345                 350         


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        355                 360                 365             


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    370                 375                 


<210>  101
<211>  345
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL7Ralpha_CISC

<400>  101

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Gly Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu 
        115                 120                 125             


Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile 
    130                 135                 140                 


Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro 
145                 150                 155                 160 


Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro 
                165                 170                 175     


Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys 
            180                 185                 190         


Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly 
        195                 200                 205             


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
    210                 215                 220                 


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
225                 230                 235                 240 


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
                245                 250                 255     


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
            260                 265                 270         


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
        275                 280                 285             


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
    290                 295                 300                 


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
305                 310                 315                 320 


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
                325                 330                 335     


Thr Met Ser Ser Phe Tyr Gln Asn Gln 
            340                 345 


<210>  102
<211>  443
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rbeta_CISC

<400>  102

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser 
    130                 135                 140                 


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
145                 150                 155                 160 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
                165                 170                 175     


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
            180                 185                 190         


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
        195                 200                 205             


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
    210                 215                 220                 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
225                 230                 235                 240 


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
                245                 250                 255     


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
            260                 265                 270         


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
        275                 280                 285             


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
    290                 295                 300                 


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
305                 310                 315                 320 


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
                325                 330                 335     


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
            340                 345                 350         


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
        355                 360                 365             


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
    370                 375                 380                 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
385                 390                 395                 400 


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
                405                 410                 415     


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
            420                 425                 430         


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        435                 440             


<210>  103
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Rgamma_CISC

<400>  103

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210>  104
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL2Ralpha_CISC

<400>  104

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile 
    130                 135                 140                 


Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys 
145                 150                 155                 160 


Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro 
                165                 170                 175     


Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn 
            180                 185                 190         


Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His 
        195                 200                 205             


Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
    210                 215                 220                 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
225                 230                 235                 240 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
                245                 250                 255     


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
            260                 265                 270         


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
        275                 280                 285             


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
    290                 295                 300                 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
                325                 330                 335     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            340                 345                 350         


Ser Phe Tyr Gln Asn Gln 
        355             


<210>  105
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IL7Ralpha_CISC

<400>  105

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile 
    130                 135                 140                 


Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys 
145                 150                 155                 160 


Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro 
                165                 170                 175     


Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn 
            180                 185                 190         


Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His 
        195                 200                 205             


Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
    210                 215                 220                 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
225                 230                 235                 240 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
                245                 250                 255     


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
            260                 265                 270         


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
        275                 280                 285             


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
    290                 295                 300                 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
                325                 330                 335     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            340                 345                 350         


Ser Phe Tyr Gln Asn Gln 
        355             


<210>  106
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  MPL_CISC

<400>  106

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly 
    130                 135                 140                 


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
145                 150                 155                 160 


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
                165                 170                 175     


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
            180                 185                 190         


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
        195                 200                 205             


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys 
    210                 215                 220                 


Ser Ser Gln Ala Gln Met Asp Tyr Arg Arg Leu Gln Pro Ser Cys Leu 
225                 230                 235                 240 


Gly Thr Met Pro Leu Ser Val Cys Pro Pro Met Ala Glu Ser Gly Ser 
                245                 250                 255     


Cys Cys Thr Thr His Ile Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr 
            260                 265                 270         


Trp Gln Gln Pro 
        275     


<210>  107
<211>  10053
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  expression vector

<400>  107
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gggcggtagt cagaaccttg     2760

tgataccatg ggccccagaa aatctcacac ttcataaact ttccgaatca caactcgaac     2820

tcaactggaa taaccggttc ctgaatcact gtcttgaaca cctggtacaa tatcggaccg     2880

actgggatca ctcatggaca gaacaatctg tggactatag gcacaaattc tcactcccaa     2940

gcgtagacgg ccaaaaaaga tacacttttc gcgtacgatc ccgctttaat cctctctgcg     3000

gctctgctca gcactggagt gaatggtccc atcccattca ttggggatcc aacacatcaa     3060

aagagaaccc ctttctgttc gcattggagg ccgtagtcat atctgttgga tccatgggac     3120

ttattatctc cctgttgtgt gtgtacttct ggctggaacg gactatgccc aggatcccca     3180

cgctcaagaa tctggaagat ctcgtcacag aataccatgg taatttcagc gcctggagcg     3240

gagtctctaa gggtctggcc gaatccctcc aacccgatta ttctgaacgg ttgtgcctcg     3300

tatccgaaat accaccaaaa ggcggggctc tgggtgaggg cccaggggcg agtccgtgca     3360

atcaacacag cccgtattgg gcccctcctt gttatacgtt gaagcccgaa actggaagcg     3420

gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac cctggaccta     3480

tggcactgcc cgtgaccgcc ctgctgctgc ctctggccct gctgctgcac gcagcccggc     3540

ctatcctgtg gcacgagatg tggcacgagg gcctggagga ggccagcagg ctgtattttg     3600

gcgagcgcaa cgtgaagggc atgttcgagg tgctggagcc tctgcacgcc atgatggaga     3660

gaggcccaca gaccctgaag gagacatcct ttaaccaggc ctatggacgg gacctgatgg     3720

aggcacagga gtggtgcaga aagtacatga agtctggcaa tgtgaaggac ctgctgcagg     3780

cctgggatct gtactatcac gtgtttcgga gaatctccaa gggaggttca aaaccttttg     3840

agaaccttag actgatggcg cccatctctc tgcaggtagt tcacgttgag acccatagat     3900

gcaatataag ctgggaaatc tcacaagcca gccattactt tgaacggcat ttggaattcg     3960

aggcccgaac actttccccc ggtcatacgt gggaagaagc tcctctcttg acgctgaagc     4020

agaagcagga gtggatttgt ctggagactt tgactcctga tactcagtat gagttccaag     4080

ttcgggtgaa accactccaa ggcgagttca cgacgtggtc tccgtggagt caaccgttgg     4140

cgttccgcac gaagcccgct gcccttggca aagacacgat tccgtggctt gggcatctgc     4200

tcgttgggct gagtggtgcg tttggtttca tcatcttggt ctatctcttg atcaattgca     4260

gaaatacagg cccttggctg aaaaaagtgc tcaagtgtaa tacccccgac ccaagcaagt     4320

tcttctccca gctttcttca gagcatggag gcgatgtgca gaaatggctc tcttcacctt     4380

ttccctcctc aagcttctcc ccgggagggc tggcgcccga gatttcacct cttgaggtac     4440

ttgaacgaga caaggttacc caacttctcc ttcaacagga taaggtaccc gaacctgcga     4500

gccttagctc caaccactct cttacgagct gcttcaccaa tcagggatac ttctttttcc     4560

accttcccga tgcgctggaa atcgaagctt gtcaagttta ctttacctat gatccatata     4620

gcgaggaaga tcccgacgaa ggagtcgccg gtgcgcccac gggttcctca ccccaacctc     4680

tccagcctct ctcaggagaa gatgatgctt attgcacttt tcccagtaga gacgatctcc     4740

tcctcttttc tccatctctt ttggggggac cttccccccc ttctacggca cctggcgggt     4800

ctggtgctgg cgaggagcgg atgccgccgt ccctccagga gcgagtacca cgagattggg     4860

atccccagcc acttggaccc cccacccccg gcgtacctga ccttgtcgat tttcaacctc     4920

cccctgaatt ggtgctgcga gaggctgggg aggaagttcc ggacgctggg ccgagggagg     4980

gcgtgtcctt tccatggagt aggcctccag gtcaaggcga gtttagggct ctcaacgcgc     5040

ggctgccgtt gaatacagac gcttatctct cactgcagga actgcaaggt caggacccaa     5100

cacatcttgt aggatctggt gctactaatt tttctctttt gaagcaagct ggagatgttg     5160

aagagaaccc tggtccagtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc     5220

tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg     5280

gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg     5340

tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc     5400

ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg     5460

agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg     5520

agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca     5580

acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg     5640

acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca     5700

gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc     5760

tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc     5820

gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg     5880

agctgtacaa gtaaactagt gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat     5940

tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc     6000

ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct     6060

ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca     6120

ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt     6180

ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg     6240

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga     6300

agctgacgtc ctttccatgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt     6360

ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc     6420

cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt     6480

gggccgcctc cccgcctgga attcgagctc ggtaccttta agaccaatga cttacaaggc     6540

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc     6600

ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg     6660

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc     6720

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct     6780

cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat     6840

tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc     6900

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     6960

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct     7020

ctagctatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     7080

atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag     7140

tgaggaggct tttttggagg cctaggcttt tgcgtcgaga cgtacccaat tcgccctata     7200

gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc     7260

ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata     7320

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc     7380

gcgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     7440

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     7500

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     7560

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     7620

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     7680

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     7740

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     7800

ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc ccaggtggca cttttcgggg     7860

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     7920

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     7980

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     8040

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     8100

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     8160

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     8220

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     8280

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     8340

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     8400

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     8460

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     8520

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     8580

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     8640

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     8700

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     8760

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     8820

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     8880

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     8940

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     9000

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     9060

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     9120

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     9180

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     9240

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     9300

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     9360

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     9420

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     9480

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     9540

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     9600

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     9660

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     9720

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     9780

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     9840

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     9900

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     9960

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa    10020

ccctcactaa agggaacaaa agctggagct gca                                 10053


<210>  108
<211>  10035
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  expression vector

<400>  108
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gcaaaacttg gtgattcctt     2760

gggccccaga aaatctcacg cttcacaagt tgtccgaatc ccagctcgag ctcaactgga     2820

ataatagatt tcttaatcat tgtttggaac acctggttca atatagaacg gattgggacc     2880

actcatggac cgagcagtca gttgactacc gccacaaatt ttcacttccc agcgtagatg     2940

ggcagaagag gtacacattt agggtcagat ccaggtttaa tcctctgtgt ggttctgctc     3000

aacactggtc tgagtggagc catccgatcc actggggctc aaatacctct aaagaaaatc     3060

cgttcctctt tgcgctcgaa gccgttgtta tcagcgtcgg aagcatggga cttatcattt     3120

cccttctctg cgtgtacttc tggctggagc ggacgatgcc gcggattccg acgctcaaaa     3180

acctggagga ccttgtaaca gaatatcacg gtaatttctc cgcttggagt ggcgtatcaa     3240

aggggcttgc tgagtccctt caaccggatt actctgagcg cctctgcttg gtgtccgaga     3300

tacctcccaa aggaggtgca cttggggagg ggccaggcgc gtccccttgc aatcagcata     3360

gtccgtattg ggcgcccccc tgttataccc tcaaaccgga aacgggaagc ggagctacta     3420

acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct atggcactgc     3480

ccgtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcccgg cctatcctgt     3540

ggcacgagat gtggcacgag ggcctggagg aggccagcag gctgtatttt ggcgagcgca     3600

acgtgaaggg catgttcgag gtgctggagc ctctgcacgc catgatggag agaggcccac     3660

agaccctgaa ggagacatcc tttaaccagg cctatggacg ggacctgatg gaggcacagg     3720

agtggtgcag aaagtacatg aagtctggca atgtgaagga cctgctgcag gcctgggatc     3780

tgtactatca cgtgtttcgg agaatctcca agaaaccttt tgagaacctt agactgatgg     3840

cgcccatctc tctgcaggta gttcacgttg agacccatag atgcaatata agctgggaaa     3900

tctcacaagc cagccattac tttgaacggc atttggaatt cgaggcccga acactttccc     3960

ccggtcatac gtgggaagaa gctcctctct tgacgctgaa gcagaagcag gagtggattt     4020

gtctggagac tttgactcct gatactcagt atgagttcca agttcgggtg aaaccactcc     4080

aaggcgagtt cacgacgtgg tctccgtgga gtcaaccgtt ggcgttccgc acgaagcccg     4140

ctgcccttgg caaagacacg attccgtggc ttgggcatct gctcgttggg ctgagtggtg     4200

cgtttggttt catcatcttg gtctatctct tgatcaattg cagaaataca ggcccttggc     4260

tgaaaaaagt gctcaagtgt aatacccccg acccaagcaa gttcttctcc cagctttctt     4320

cagagcatgg aggcgatgtg cagaaatggc tctcttcacc ttttccctcc tcaagcttct     4380

ccccgggagg gctggcgccc gagatttcac ctcttgaggt acttgaacga gacaaggtta     4440

cccaacttct ccttcaacag gataaggtac ccgaacctgc gagccttagc tccaaccact     4500

ctcttacgag ctgcttcacc aatcagggat acttcttttt ccaccttccc gatgcgctgg     4560

aaatcgaagc ttgtcaagtt tactttacct atgatccata tagcgaggaa gatcccgacg     4620

aaggagtcgc cggtgcgccc acgggttcct caccccaacc tctccagcct ctctcaggag     4680

aagatgatgc ttattgcact tttcccagta gagacgatct cctcctcttt tctccatctc     4740

ttttgggggg accttccccc ccttctacgg cacctggcgg gtctggtgct ggcgaggagc     4800

ggatgccgcc gtccctccag gagcgagtac cacgagattg ggatccccag ccacttggac     4860

cccccacccc cggcgtacct gaccttgtcg attttcaacc tccccctgaa ttggtgctgc     4920

gagaggctgg ggaggaagtt ccggacgctg ggccgaggga gggcgtgtcc tttccatgga     4980

gtaggcctcc aggtcaaggc gagtttaggg ctctcaacgc gcggctgccg ttgaatacag     5040

acgcttatct ctcactgcag gaactgcaag gtcaggaccc aacacatctt gtaggatctg     5100

gtgctactaa tttttctctt ttgaagcaag ctggagatgt tgaagagaac cctggtccag     5160

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     5220

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     5280

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     5340

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     5400

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     5460

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     5520

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     5580

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     5640

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     5700

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     5760

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     5820

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaacta     5880

gtgtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact     5940

atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg     6000

cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg     6060

aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa     6120

cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc     6180

ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg     6240

ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat     6300

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt     6360

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc     6420

cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcctg     6480

gaattcgagc tcggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca     6540

ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct     6600

gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     6660

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     6720

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     6780

gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt tataacttgc     6840

aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa     6900

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     6960

tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta     7020

actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca     7080

gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga     7140

ggcctaggct tttgcgtcga gacgtaccca attcgcccta tagtgagtcg tattacgcgc     7200

gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta     7260

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg     7320

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcgacgcg ccctgtagcg     7380

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     7440

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     7500

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     7560

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     7620

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     7680

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     7740

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca     7800

aaatattaac gtttacaatt tcccaggtgg cacttttcgg ggaaatgtgc gcggaacccc     7860

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     7920

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc     7980

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt     8040

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct     8100

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac     8160

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact     8220

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa     8280

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga     8340

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt     8400

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga     8460

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg     8520

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat     8580

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat     8640

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc     8700

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga     8760

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc     8820

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     8880

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     8940

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     9000

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     9060

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     9120

accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     9180

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     9240

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     9300

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     9360

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag     9420

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     9480

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     9540

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     9600

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc     9660

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac     9720

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct     9780

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc     9840

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt     9900

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac     9960

aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca    10020

aaagctggag ctgca                                                     10035


<210>  109
<211>  9405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  expression vector

<400>  109
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta     2340

gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg     2400

ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat     2460

tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga     2520

agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag     2580

tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga     2640

ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg     2700

ccaccctggt gttcgatgtg gagctgctga agctgggcga gggatccaac acatcaaaag     2760

agaacccctt tctgttcgca ttggaggccg tagtcatatc tgttggatcc atgggactta     2820

ttatctccct gttgtgtgtg tacttctggc tggaacggac tatgcccagg atccccacgc     2880

tcaagaatct ggaagatctc gtcacagaat accatggtaa tttcagcgcc tggagcggag     2940

tctctaaggg tctggccgaa tccctccaac ccgattattc tgaacggttg tgcctcgtat     3000

ccgaaatacc accaaaaggc ggggctctgg gtgagggccc aggggcgagt ccgtgcaatc     3060

aacacagccc gtattgggcc cctccttgtt atacgttgaa gcccgaaact ggaagcggag     3120

ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctatgg     3180

cactgcccgt gaccgccctg ctgctgcctc tggccctgct gctgcacgca gcccggccta     3240

tcctgtggca cgagatgtgg cacgagggcc tggaggaggc cagcaggctg tattttggcg     3300

agcgcaacgt gaagggcatg ttcgaggtgc tggagcctct gcacgccatg atggagagag     3360

gcccacagac cctgaaggag acatccttta accaggccta tggacgggac ctgatggagg     3420

cacaggagtg gtgcagaaag tacatgaagt ctggcaatgt gaaggacctg ctgcaggcct     3480

gggatctgta ctatcacgtg tttcggagaa tctccaaggg caaagacacg attccgtggc     3540

ttgggcatct gctcgttggg ctgagtggtg cgtttggttt catcatcttg gtctatctct     3600

tgatcaattg cagaaataca ggcccttggc tgaaaaaagt gctcaagtgt aatacccccg     3660

acccaagcaa gttcttctcc cagctttctt cagagcatgg aggcgatgtg cagaaatggc     3720

tctcttcacc ttttccctcc tcaagcttct ccccgggagg gctggcgccc gagatttcac     3780

ctcttgaggt acttgaacga gacaaggtta cccaacttct ccttcaacag gataaggtac     3840

ccgaacctgc gagccttagc tccaaccact ctcttacgag ctgcttcacc aatcagggat     3900

acttcttttt ccaccttccc gatgcgctgg aaatcgaagc ttgtcaagtt tactttacct     3960

atgatccata tagcgaggaa gatcccgacg aaggagtcgc cggtgcgccc acgggttcct     4020

caccccaacc tctccagcct ctctcaggag aagatgatgc ttattgcact tttcccagta     4080

gagacgatct cctcctcttt tctccatctc ttttgggggg accttccccc ccttctacgg     4140

cacctggcgg gtctggtgct ggcgaggagc ggatgccgcc gtccctccag gagcgagtac     4200

cacgagattg ggatccccag ccacttggac cccccacccc cggcgtacct gaccttgtcg     4260

attttcaacc tccccctgaa ttggtgctgc gagaggctgg ggaggaagtt ccggacgctg     4320

ggccgaggga gggcgtgtcc tttccatgga gtaggcctcc aggtcaaggc gagtttaggg     4380

ctctcaacgc gcggctgccg ttgaatacag acgcttatct ctcactgcag gaactgcaag     4440

gtcaggaccc aacacatctt gtaggatctg gtgctactaa tttttctctt ttgaagcaag     4500

ctggagatgt tgaagagaac cctggtccag tgagcaaggg cgaggagctg ttcaccgggg     4560

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     4620

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     4680

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     4740

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     4800

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     4860

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     4920

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     4980

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     5040

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     5100

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     5160

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     5220

tcggcatgga cgagctgtac aagtaaacta gtgtcgacaa tcaacctctg gattacaaaa     5280

tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg     5340

ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct     5400

tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg     5460

gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct     5520

gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg     5580

ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg     5640

tgttgtcggg gaagctgacg tcctttccat ggctgctcgc ctgtgttgcc acctggattc     5700

tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc     5760

gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc     5820

ggatctccct ttgggccgcc tccccgcctg gaattcgagc tcggtacctt taagaccaat     5880

gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg     5940

gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt     6000

agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca     6060

ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa     6120

ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta gtagttcatg     6180

tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa     6240

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     6300

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     6360

tcatgtctgg ctctagctat cccgccccta actccgccca gttccgccca ttctccgccc     6420

catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta     6480

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcgtcga gacgtaccca     6540

attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg     6600

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     6660

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     6720

atggcgaatg gcgcgacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     6780

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     6840

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     6900

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     6960

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     7020

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     7080

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     7140

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcccaggtgg     7200

cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa     7260

tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa     7320

gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct     7380

tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg     7440

tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg     7500

ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt     7560

atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga     7620

cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga     7680

attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac     7740

gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg     7800

ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac     7860

gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct     7920

agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct     7980

gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg     8040

gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat     8100

ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg     8160

tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat     8220

tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct     8280

catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     8340

gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     8400

aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     8460

gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta     8520

gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     8580

gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     8640

atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     8700

cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     8760

cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     8820

agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     8880

tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     8940

gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     9000

catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg     9060

agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc     9120

ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     9180

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag     9240

ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg     9300

tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa     9360

gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgca                     9405


<210>  110
<211>  1293
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon optimized human FOXP3 cDNA Without stop codon 

<400>  110
atgcctaatc ctcggcctgg aaagcctagc gctccttctc ttgctctggg accttctcct       60

ggcgcctctc catcttggag agccgctcct aaagccagcg atctgctggg agctagagga      120

cctggcggca catttcaggg cagagatctt agaggcggag cccacgctag ctcctccagc      180

cttaatccta tgcctcctag ccagctccag ctgcctacac tgcctctggt tatggtggct      240

cctagcggag ctagactggg ccctctgcct catctgcaag ctctgctgca ggacagaccc      300

cacttcatgc accagctgag caccgtggat gcccacgcaa gaacacctgt gctgcaggtt      360

caccctctgg aatccccagc catgatcagc ctgacacctc caacaacagc caccggcgtg      420

ttcagcctga aagccagacc tggactgcct cctggcatca atgtggccag cctggaatgg      480

gtgtccagag aacctgctct gctgtgcaca ttccccaatc caagcgctcc cagaaaggac      540

agcacactgt ctgccgtgcc tcagagcagc tatcccctgc ttgctaacgg cgtgtgcaag      600

tggcctggat gcgagaaggt gttcgaggaa cccgaggact tcctgaagca ctgccaggcc      660

gatcatctgc tggacgagaa aggcagagcc cagtgtctgc tccagcgcga gatggtgcag      720

tctctggaac agcagctggt cctggaaaaa gaaaagctga gcgccatgca ggcccacctg      780

gccggaaaaa tggccctgac aaaggccagc agcgtggcct cttctgataa gggcagctgc      840

tgcattgtgg ccgctggatc tcagggacct gtggttcctg cttggagcgg acctagagag      900

gcccctgatt ctctgtttgc cgtgcggaga cacctgtggg gctctcacgg caactctact      960

ttccccgagt tcctgcacaa catggactac ttcaagttcc acaacatgcg gcctccattc     1020

acctacgcca cactgatcag atgggccatt ctggaagccc ctgagaagca gagaaccctg     1080

aacgagatct accactggtt tacccggatg ttcgccttct tccggaatca ccctgccacc     1140

tggaagaacg ccatccggca caatctgagc ctgcacaagt gcttcgtgcg cgtggaatct     1200

gagaaaggcg ccgtgtggac agtggacgag ctggaattca gaaagaagag aagccagcgg     1260

cctagccggt gcagcaatcc tacacctgga cct                                  1293


<210>  111
<211>  1296
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon optimized human FOXP3 cDNA  With stop codon 

<400>  111
atgcctaatc ctcggcctgg aaagcctagc gctccttctc ttgctctggg accttctcct       60

ggcgcctctc catcttggag agccgctcct aaagccagcg atctgctggg agctagagga      120

cctggcggca catttcaggg cagagatctt agaggcggag cccacgctag ctcctccagc      180

cttaatccta tgcctcctag ccagctccag ctgcctacac tgcctctggt tatggtggct      240

cctagcggag ctagactggg ccctctgcct catctgcaag ctctgctgca ggacagaccc      300

cacttcatgc accagctgag caccgtggat gcccacgcaa gaacacctgt gctgcaggtt      360

caccctctgg aatccccagc catgatcagc ctgacacctc caacaacagc caccggcgtg      420

ttcagcctga aagccagacc tggactgcct cctggcatca atgtggccag cctggaatgg      480

gtgtccagag aacctgctct gctgtgcaca ttccccaatc caagcgctcc cagaaaggac      540

agcacactgt ctgccgtgcc tcagagcagc tatcccctgc ttgctaacgg cgtgtgcaag      600

tggcctggat gcgagaaggt gttcgaggaa cccgaggact tcctgaagca ctgccaggcc      660

gatcatctgc tggacgagaa aggcagagcc cagtgtctgc tccagcgcga gatggtgcag      720

tctctggaac agcagctggt cctggaaaaa gaaaagctga gcgccatgca ggcccacctg      780

gccggaaaaa tggccctgac aaaggccagc agcgtggcct cttctgataa gggcagctgc      840

tgcattgtgg ccgctggatc tcagggacct gtggttcctg cttggagcgg acctagagag      900

gcccctgatt ctctgtttgc cgtgcggaga cacctgtggg gctctcacgg caactctact      960

ttccccgagt tcctgcacaa catggactac ttcaagttcc acaacatgcg gcctccattc     1020

acctacgcca cactgatcag atgggccatt ctggaagccc ctgagaagca gagaaccctg     1080

aacgagatct accactggtt tacccggatg ttcgccttct tccggaatca ccctgccacc     1140

tggaagaacg ccatccggca caatctgagc ctgcacaagt gcttcgtgcg cgtggaatct     1200

gagaaaggcg ccgtgtggac agtggacgag ctggaattca gaaagaagag aagccagcgg     1260

cctagccggt gcagcaatcc tacacctgga ccttga                               1296


<210>  112
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  naked FRB domain

<400>  112

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  113
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  naked FRB domain

<400>  113

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  114
<211>  1299
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCbeta FRB_IL2Rbeta nucleotide sequence  coding sequence only 

<400>  114
atggcactgc ccgtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcccgg       60

cctatcctgt ggcacgagat gtggcacgag ggcctggagg aggccagcag gctgtatttt      120

ggcgagcgca acgtgaaggg catgttcgag gtgctggagc ctctgcacgc catgatggag      180

agaggcccac agaccctgaa ggagacatcc tttaaccagg cctatggacg ggacctgatg      240

gaggcacagg agtggtgcag aaagtacatg aagtctggca atgtgaagga cctgctgcag      300

gcctgggatc tgtactatca cgtgtttcgg agaatctcca agccagcagc tctcggcaaa      360

gacacgattc cgtggcttgg gcatctgctc gttgggctga gcggtgcgtt tggtttcatc      420

atcttggtct atctcttgat caattgcaga aatacaggcc cttggctgaa aaaagtgctc      480

aagtgtaata cccccgaccc aagcaagttc ttctcccagc tttcttcaga gcatggaggc      540

gatgtgcaga aatggctctc ttcacctttt ccctcctcaa gcttctcccc gggagggctg      600

gcgcccgaga tttcacctct tgaggtactt gaacgagaca aggttaccca acttctcctt      660

caacaggata aggtacccga acctgcgagc cttagctcca accactctct tacgagctgc      720

ttcaccaatc agggatactt ctttttccac cttcccgatg cgctggaaat cgaagcttgt      780

caagtttact ttacctatga tccatatagc gaggaagatc ccgacgaagg agtcgccggt      840

gcgcccacgg gttcctcacc ccaacctctc cagcctctct caggagaaga tgatgcttat      900

tgcacttttc ccagtagaga cgatctcctc ctcttttctc catctctttt ggggggacct      960

tccccccctt ctacggcacc tggcgggtct ggtgctggcg aggagcggat gccgccgtcc     1020

ctccaggagc gagtaccacg agattgggat ccccagccac ttggaccccc cacccccggc     1080

gtacctgacc ttgtcgattt tcaacctccc cctgaattgg tgctgcgaga ggctggggag     1140

gaagttccgg acgctgggcc gagggagggc gtgtcctttc catggagtag gcctccaggt     1200

caaggcgagt ttagggctct caacgcgcgg ctgccgttga atacagacgc ttatctctca     1260

ctgcaggaac tgcaaggtca ggacccaaca catcttgta                            1299


<210>  115
<211>  433
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  CISCbeta FRB_IL2Rbeta amino acid sequence

<400>  115

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            20                  25                  30          


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        35                  40                  45              


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    50                  55                  60                  


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
65                  70                  75                  80  


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                85                  90                  95      


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            100                 105                 110         


Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His 
        115                 120                 125             


Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr 
    130                 135                 140                 


Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu 
145                 150                 155                 160 


Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser 
                165                 170                 175     


Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser 
            180                 185                 190         


Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu 
        195                 200                 205             


Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys 
    210                 215                 220                 


Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys 
225                 230                 235                 240 


Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu 
                245                 250                 255     


Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu 
            260                 265                 270         


Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln 
        275                 280                 285             


Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro 
    290                 295                 300                 


Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg 
                325                 330                 335     


Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln 
            340                 345                 350         


Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln 
        355                 360                 365             


Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp 
    370                 375                 380                 


Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly 
385                 390                 395                 400 


Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp 
                405                 410                 415     


Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu 
            420                 425                 430         


Val 
    


<210>  116
<211>  765
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CISCgamma FKBP_IL2Rgamma nucleotide sequence  coding sequence 
       only codon optimized

<400>  116
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaact                      765


<210>  117
<211>  255
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  CISCgamma FKBP_IL2Rgamma  amino acid sequence

<400>  117

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250                 255 


<210>  118
<211>  2463
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DISC CISC_FRB nucleotide sequence  coding sequence only codon 
       optimized 

<400>  118
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagctact      780

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatggcactg      840

cccgtgaccg ccctgctgct gcctctggcc ctgctgctgc acgcagcccg gcctatcctg      900

tggcacgaga tgtggcacga gggcctggag gaggccagca ggctgtattt tggcgagcgc      960

aacgtgaagg gcatgttcga ggtgctggag cctctgcacg ccatgatgga gagaggccca     1020

cagaccctga aggagacatc ctttaaccag gcctatggac gggacctgat ggaggcacag     1080

gagtggtgca gaaagtacat gaagtctggc aatgtgaagg acctgctgca ggcctgggat     1140

ctgtactatc acgtgtttcg gagaatctcc aagccagcag ctctcggcaa agacacgatt     1200

ccgtggcttg ggcatctgct cgttgggctg agcggtgcgt ttggtttcat catcttggtc     1260

tatctcttga tcaattgcag aaatacaggc ccttggctga aaaaagtgct caagtgtaat     1320

acccccgacc caagcaagtt cttctcccag ctttcttcag agcatggagg cgatgtgcag     1380

aaatggctct cttcaccttt tccctcctca agcttctccc cgggagggct ggcgcccgag     1440

atttcacctc ttgaggtact tgaacgagac aaggttaccc aacttctcct tcaacaggat     1500

aaggtacccg aacctgcgag ccttagctcc aaccactctc ttacgagctg cttcaccaat     1560

cagggatact tctttttcca ccttcccgat gcgctggaaa tcgaagcttg tcaagtttac     1620

tttacctatg atccatatag cgaggaagat cccgacgaag gagtcgccgg tgcgcccacg     1680

ggttcctcac cccaacctct ccagcctctc tcaggagaag atgatgctta ttgcactttt     1740

cccagtagag acgatctcct cctcttttct ccatctcttt tggggggacc ttccccccct     1800

tctacggcac ctggcgggtc tggtgctggc gaggagcgga tgccgccgtc cctccaggag     1860

cgagtaccac gagattggga tccccagcca cttggacccc ccacccccgg cgtacctgac     1920

cttgtcgatt ttcaacctcc ccctgaattg gtgctgcgag aggctgggga ggaagttccg     1980

gacgctgggc cgagggaggg cgtgtccttt ccatggagta ggcctccagg tcaaggcgag     2040

tttagggctc tcaacgcgcg gctgccgttg aatacagacg cttatctctc actgcaggaa     2100

ctgcaaggtc aggacccaac acatcttgta ggatctggtg ctactaattt ttctcttttg     2160

aagcaagctg gagatgttga agagaacccc ggtccggaga tgtggcatga gggtctggaa     2220

gaagcgtctc gactgtactt tggtgagcgc aatgtgaagg gcatgtttga agtcctcgaa     2280

ccccttcatg ccatgatgga acgcggaccc cagaccttga aggagacaag ttttaaccaa     2340

gcttacggaa gagacctgat ggaagcccag gaatggtgca ggaaatacat gaaaagcggg     2400

aatgtgaagg acttgctcca agcgtgggac ctgtactatc atgtctttag gcgcattagt     2460

aag                                                                   2463


<210>  119
<211>  821
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  DISC CISC_FRB uDISC amino acid sequence

<400>  119

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        275                 280                 285             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His Glu Met 
    290                 295                 300                 


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
305                 310                 315                 320 


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
                325                 330                 335     


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
            340                 345                 350         


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
        355                 360                 365             


Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His 
    370                 375                 380                 


Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile 
385                 390                 395                 400 


Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe 
                405                 410                 415     


Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp 
            420                 425                 430         


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
        435                 440                 445             


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
    450                 455                 460                 


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
465                 470                 475                 480 


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
                485                 490                 495     


Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His 
            500                 505                 510         


Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu 
        515                 520                 525             


Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp 
    530                 535                 540                 


Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr 
545                 550                 555                 560 


Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala 
                565                 570                 575     


Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser 
            580                 585                 590         


Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly 
        595                 600                 605             


Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg 
    610                 615                 620                 


Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp 
625                 630                 635                 640 


Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly 
                645                 650                 655     


Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp 
            660                 665                 670         


Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu 
        675                 680                 685             


Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln 
    690                 695                 700                 


Asp Pro Thr His Leu Val Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
705                 710                 715                 720 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Met Trp His 
                725                 730                 735     


Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
            740                 745                 750         


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
        755                 760                 765             


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
    770                 775                 780                 


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
785                 790                 795                 800 


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
                805                 810                 815     


Arg Arg Ile Ser Lys 
            820     


<210>  120
<211>  267
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  FRB express intracellularly to function as a decoy for rapamycin 
       FRB nucleotide sequence  coding sequence only decoy codon 
       optimized WT

<400>  120
gagatgtggc atgagggtct ggaagaagcg tctcgactgt actttggtga gcgcaatgtg       60

aagggcatgt ttgaagtcct cgaacccctt catgccatga tggaacgcgg accccagacc      120

ttgaaggaga caagttttaa ccaagcttac ggaagagacc tgatggaagc ccaggaatgg      180

tgcaggaaat acatgaaaag cgggaatgtg aaggacttga cccaagcgtg ggacctgtac      240

tatcatgtct ttaggcgcat tagtaag                                          267


<210>  121
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  FRB amino acid sequence

<400>  121

Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
1               5                   10                  15      


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
            20                  25                  30          


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
        35                  40                  45              


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
    50                  55                  60                  


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
65                  70                  75                  80  


Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  


<210>  122
<211>  825
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LNGFR coding sequence with stop codon

<400>  122
atgggggcag gtgccaccgg acgagccatg gacgggccgc gcctgctgct gttgctgctt       60

ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacacagc      120

ggtgagtgct gcaaagcctg caacctgggc gagggtgtgg cccagccttg tggagccaac      180

cagaccgtgt gtgagccctg cctggacagc gtgacgttct ccgacgtggt gagcgcgacc      240

gagccgtgca agccgtgcac cgagtgcgtg gggctccaga gcatgtcggc gccgtgcgtg      300

gaggccgacg acgccgtgtg ccgctgcgcc tacggctact accaggatga gacgactggg      360

cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtgttctc ctgccaggac      420

aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attccgacga ggccaaccac      480

gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct ccgcgagtgc      540

acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac acggtccaca      600

cccccagagg gctcggacag cacagccccc agcacccagg agcctgaggc acctccagaa      660

caagacctca tagccagcac ggtggcaggt gtggtgacca cagtgatggg cagctcccag      720

cccgtggtga cccgaggcac caccgacaac ctcatccctg tctattgctc catcctggct      780

gctgtggttg tgggtcttgt ggcctacata gccttcaaga ggtga                      825


<210>  123
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LNGFRe LNGFR epitope coding sequence  2A P2A self cleaving 
       peptide

<400>  123
ggaagcggag cgactaactt cagcctgctg aagcaggccg gagatgtgga ggaaaaccct       60

ggaccg                                                                  66


<210>  124
<211>  258
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_25kb human FOXP3 5'HA designed for both TALEN and Cas9 

<400>  124
tgctagcgtg ggcaggcaag ccaggtgctg gacctctgca cgtggggcat gtgtgggtat       60

gtacatgtac ctgtgttctt ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtctagagc      120

tggggtgcaa ctatggggcc cctcgggaca tgtcccagcc aatgcctgct ttgaccagag      180

gagtgtccac gtggctcagg tggtcgagta tctcataccg ccctagcaca cgtgtgactc      240

ctttccccta ttgtctac                                                    258


<210>  125
<211>  296
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_3kb human FOXP3 5'HA for Cas9_T9

<400>  125
catgtgtggg tatgtacatg tacctgtgtt cttggtgtgt gtgtgtgtgt gtgtgtgtgt       60

gtgtgtctag agctggggtg caactatggg gcccctcggg acatgtccca gccaatgcct      120

gctttgacca gaggagtgtc cacgtggctc aggtggtcga gtatctcata ccgccctagc      180

acacgtgtga ctcctttccc ctattgtcta cgcagcctgc ccttggacaa ggacccgatg      240

cccaacccca ggcctggcaa gccctcggcc ccttccttgg cccttggccc atcccc          296


<210>  126
<211>  452
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_45kb human FOXP3 5'HA for Cas9_T9

<400>  126
agcctgtgca gggtgcaggg agggctagag gcctgaggct tgaaacagct ctcaagtgga       60

gggggaaaca accattgccc tcatagagga cacatccaca ccagggctgt gctagcgtgg      120

gcaggcaagc caggtgctgg acctctgcac gtggggcatg tgtgggtatg tacatgtacc      180

tgtgttcttg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtctagagct ggggtgcaac      240

tatggggccc ctcgggacat gtcccagcca atgcctgctt tgaccagagg agtgtccacg      300

tggctcaggt ggtcgagtat ctcataccgc cctagcacac gtgtgactcc tttcccctat      360

tgtctacgca gcctgccctt ggacaaggac ccgatgccca accccaggcc tggcaagccc      420

tcggcccctt ccttggccct tggcccatcc cc                                    452


<210>  127
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb human FOXP3 5'HA for Cas9_T9

<400>  127
atcacttgcc aggactgtta caatagcctc ctcactagcc ccactcacag cagccagatg       60

aatcttttga gtccatgcct agtcactggg gcaaaatagg actccgagga gaaagtccga      120

gaccagctcc ggcaagatga gcaaacacag cctgtgcagg gtgcagggag ggctagaggc      180

ctgaggcttg aaacagctct caagtggagg gggaaacaac cattgccctc atagaggaca      240

catccacacc agggctgtgc tagcgtgggc aggcaagcca ggtgctggac ctctgcacgt      300

ggggcatgtg tgggtatgta catgtacctg tgttcttggt gtgtgtgtgt gtgtgtgtgt      360

gtgtgtgtgt ctagagctgg ggtgcaacta tggggcccct cgggacatgt cccagccaat      420

gcctgctttg accagaggag tgtccacgtg gctcaggtgg tcgagtatct cataccgccc      480

tagcacacgt gtgactcctt tcccctattg tctacgcagc ctgcccttgg acaaggaccc      540

gatgcccaac cccaggcctg gcaagccctc ggccccttcc ttggcccttg gcccatcccc      600


<210>  128
<211>  785
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_8kb human FOXP3 5'HA for Cas9_T9

<400>  128
atctcaggta atgtcagctc ggtccttcca gctgctcaag ctaaaaccca tgtcactttg       60

actctccctc ttgcccacta catccaagct gctagcactg ctcctgatcc agcttcagat      120

taagtctcag aatctaccca cttctcgcct tctccactgc caccagccca ttctgtgcca      180

gcatcatcac ttgccaggac tgttacaata gcctcctcac tagccccact cacagcagcc      240

agatgaatct tttgagtcca tgcctagtca ctggggcaaa ataggactcc gaggagaaag      300

tccgagacca gctccggcaa gatgagcaaa cacagcctgt gcagggtgca gggagggcta      360

gaggcctgag gcttgaaaca gctctcaagt ggagggggaa acaaccattg ccctcataga      420

ggacacatcc acaccagggc tgtgctagcg tgggcaggca agccaggtgc tggacctctg      480

cacgtggggc atgtgtgggt atgtacatgt acctgtgttc ttggtgtgtg tgtgtgtgtg      540

tgtgtgtgtg tgtgtctaga gctggggtgc aactatgggg cccctcggga catgtcccag      600

ccaatgcctg ctttgaccag aggagtgtcc acgtggctca ggtggtcgag tatctcatac      660

cgccctagca cacgtgtgac tcctttcccc tattgtctac gcagcctgcc cttggacaag      720

gacccgatgc ccaaccccag gcctggcaag ccctcggccc cttccttggc ccttggccca      780

tcccc                                                                  785


<210>  129
<211>  275
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_3kb human FOXP3 5'HA for Cas9_T3 

<400>  129
gacatgtccc agccaatgcc tgctttgacc agaggagtgt ccacgtggct caggtggtcg       60

agtatctcat accgccctag cacacgtgtg actcctttcc cctattgtct acgcagcctg      120

cccttggaca aggacccgat gcccaacccc aggcctggca agccctcggc cccttccttg      180

gcccttggcc catccccagg agcctcgccc agctggaggg ctgcacccaa agcctcagac      240

ctgctggggg cccggggccc agggggaacc ttcca                                 275


<210>  130
<211>  449
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_45kb human FOXP3 5'HA for Cas9_T3

<400>  130
catagaggac acatccacac cagggctgtg ctagcgtggg caggcaagcc aggtgctgga       60

cctctgcacg tggggcatgt gtgggtatgt acatgtacct gtgttcttgg tgtgtgtgtg      120

tgtgtgtgtg tgtgtgtgtg tctagagctg gggtgcaact atggggcccc tcgggacatg      180

tcccagccaa tgcctgcttt gaccagagga gtgtccacgt ggctcaggtg gtcgagtatc      240

tcataccgcc ctagcacacg tgtgactcct ttcccctatt gtctacgcag cctgcccttg      300

gacaaggacc cgatgcccaa ccccaggcct ggcaagccct cggccccttc cttggccctt      360

ggcccatccc caggagcctc gcccagctgg agggctgcac ccaaagcctc agacctgctg      420

ggggcccggg gcccaggggg aaccttcca                                        449


<210>  131
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb human FOXP3 5'HA for Cas9_T3

<400>  131
ctagtcactg gggcaaaata ggactccgag gagaaagtcc gagaccagct ccggcaagat       60

gagcaaacac agcctgtgca gggtgcaggg agggctagag gcctgaggct tgaaacagct      120

ctcaagtgga gggggaaaca accattgccc tcatagagga cacatccaca ccagggctgt      180

gctagcgtgg gcaggcaagc caggtgctgg acctctgcac gtggggcatg tgtgggtatg      240

tacatgtacc tgtgttcttg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtctagagct      300

ggggtgcaac tatggggccc ctcgggacat gtcccagcca atgcctgctt tgaccagagg      360

agtgtccacg tggctcaggt ggtcgagtat ctcataccgc cctagcacac gtgtgactcc      420

tttcccctat tgtctacgca gcctgccctt ggacaaggac ccgatgccca accccaggcc      480

tggcaagccc tcggcccctt ccttggccct tggcccatcc ccaggagcct cgcccagctg      540

gagggctgca cccaaagcct cagacctgct gggggcccgg ggcccagggg gaaccttcca      600


<210>  132
<211>  245
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_25kb human FOXP3 3'HA designed for both TALEN and Cas9 

<400>  132
gtgaggccct gggcccagga tggggcaggc agggtggggt acctggacct acaggtgccg       60

acctttactg tggcactggg cgggaggggg gctggctggg gcacaggaag tggtttctgg      120

gtcccaggca agtctgtgac ttatgcagat gttgcagggc caagaaaatc cccacctgcc      180

aggcctcaga gattggaggc tctccccgac ctcccaatcc ctgtctcagg agaggaggag      240

gccgt                                                                  245


<210>  133
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_3kb human FOXP3 3'HA for Cas9_T9

<400>  133
gcctcgccca gctggagggc tgcacccaaa gcctcagacc tgctgggggc ccggggccca       60

gggggaacct tccagggccg agatcttcga ggcggggccc atgcctcctc ttcttccttg      120

aaccccatgc caccatcgca gctgcaggtg aggccctggg cccaggatgg ggcaggcagg      180

gtggggtacc tggacctaca ggtgccgacc tttactgtgg cactgggcgg gaggggggct      240

ggctggggca caggaagtgg tttctgggtc ccaggcaagt ctgtgactta tgcagatgtt      300


<210>  134
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_45kb human FOXP3 3'HA for Cas9_T9

<400>  134
gcctcgccca gctggagggc tgcacccaaa gcctcagacc tgctgggggc ccggggccca       60

gggggaacct tccagggccg agatcttcga ggcggggccc atgcctcctc ttcttccttg      120

aaccccatgc caccatcgca gctgcaggtg aggccctggg cccaggatgg ggcaggcagg      180

gtggggtacc tggacctaca ggtgccgacc tttactgtgg cactgggcgg gaggggggct      240

ggctggggca caggaagtgg tttctgggtc ccaggcaagt ctgtgactta tgcagatgtt      300

gcagggccaa gaaaatcccc acctgccagg cctcagagat tggaggctct ccccgacctc      360

ccaatccctg tctcaggaga ggaggaggcc gtattgtagt cccatgagca tagctatgtg      420

tccccatccc catgtgacaa gagaagagga                                       450


<210>  135
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb human FOXP3 3'HA for Cas9_T9

<400>  135
gcctcgccca gctggagggc tgcacccaaa gcctcagacc tgctgggggc ccggggccca       60

gggggaacct tccagggccg agatcttcga ggcggggccc atgcctcctc ttcttccttg      120

aaccccatgc caccatcgca gctgcaggtg aggccctggg cccaggatgg ggcaggcagg      180

gtggggtacc tggacctaca ggtgccgacc tttactgtgg cactgggcgg gaggggggct      240

ggctggggca caggaagtgg tttctgggtc ccaggcaagt ctgtgactta tgcagatgtt      300

gcagggccaa gaaaatcccc acctgccagg cctcagagat tggaggctct ccccgacctc      360

ccaatccctg tctcaggaga ggaggaggcc gtattgtagt cccatgagca tagctatgtg      420

tccccatccc catgtgacaa gagaagagga ctggggccaa gtaggtgagg tgacagggct      480

gaggccagct ctgcaactta ttagctgttt gatctttaaa aagttactcg atctccatga      540

gcctcagttt ccatacgtgt aaaaggggga tgatcatagc atctaccatg tgggcttgca      600


<210>  136
<211>  794
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_8kb human FOXP3 3'HA for Cas9_T9

<400>  136
gcctcgccca gctggagggc tgcacccaaa gcctcagacc tgctgggggc ccggggccca       60

gggggaacct tccagggccg agatcttcga ggcggggccc atgcctcctc ttcttccttg      120

aaccccatgc caccatcgca gctgcaggtg aggccctggg cccaggatgg ggcaggcagg      180

gtggggtacc tggacctaca ggtgccgacc tttactgtgg cactgggcgg gaggggggct      240

ggctggggca caggaagtgg tttctgggtc ccaggcaagt ctgtgactta tgcagatgtt      300

gcagggccaa gaaaatcccc acctgccagg cctcagagat tggaggctct ccccgacctc      360

ccaatccctg tctcaggaga ggaggaggcc gtattgtagt cccatgagca tagctatgtg      420

tccccatccc catgtgacaa gagaagagga ctggggccaa gtaggtgagg tgacagggct      480

gaggccagct ctgcaactta ttagctgttt gatctttaaa aagttactcg atctccatga      540

gcctcagttt ccatacgtgt aaaaggggga tgatcatagc atctaccatg tgggcttgca      600

gtgcagagta tttgaattag acacagaaca gtgaggatca ggatggcctc tcacccacct      660

gcctttctgc ccagctgccc acactgcccc tagtcatggt ggcaccctcc ggggcacggc      720

tgggcccctt gccccactta caggcactcc tccaggacag gccacatttc atgcaccagg      780

tatggacggt gaat                                                        794


<210>  137
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_3kb human FOXP3 3'HA for Cas9_T3

<400>  137
cgagatcttc gaggcggggc ccatgcctcc tcttcttcct tgaaccccat gccaccatcg       60

cagctgcagg tgaggccctg ggcccaggat ggggcaggca gggtggggta cctggaccta      120

caggtgccga cctttactgt ggcactgggc gggagggggg ctggctgggg cacaggaagt      180

ggtttctggg tcccaggcaa gtctgtgact tatgcagatg ttgcagggcc aagaaaatcc      240

ccacctgcca ggcctcagag attggaggct ctccccgacc tcccaatccc tgtctcagga      300


<210>  138
<211>  451
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_45kb human FOXP3 3'HA for Cas9_T3

<400>  138
cgagatcttc gaggcggggc ccatgcctcc tcttcttcct tgaaccccat gccaccatcg       60

cagctgcagg tgaggccctg ggcccaggat ggggcaggca gggtggggta cctggaccta      120

caggtgccga cctttactgt ggcactgggc gggagggggg ctggctgggg cacaggaagt      180

ggtttctggg tcccaggcaa gtctgtgact tatgcagatg ttgcagggcc aagaaaatcc      240

ccacctgcca ggcctcagag attggaggct ctccccgacc tcccaatccc tgtctcagga      300

gaggaggagg ccgtattgta gtcccatgag catagctatg tgtccccatc cccatgtgac      360

aagagaagag gactggggcc aagtaggtga ggtgacaggg ctgaggccag ctctgcaact      420

tattagctgt ttgatcttta aaaagttact c                                     451


<210>  139
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb human FOXP3 3'HA for Cas9_T3

<400>  139
cgagatcttc gaggcggggc ccatgcctcc tcttcttcct tgaaccccat gccaccatcg       60

cagctgcagg tgaggccctg ggcccaggat ggggcaggca gggtggggta cctggaccta      120

caggtgccga cctttactgt ggcactgggc gggagggggg ctggctgggg cacaggaagt      180

ggtttctggg tcccaggcaa gtctgtgact tatgcagatg ttgcagggcc aagaaaatcc      240

ccacctgcca ggcctcagag attggaggct ctccccgacc tcccaatccc tgtctcagga      300

gaggaggagg ccgtattgta gtcccatgag catagctatg tgtccccatc cccatgtgac      360

aagagaagag gactggggcc aagtaggtga ggtgacaggg ctgaggccag ctctgcaact      420

tattagctgt ttgatcttta aaaagttact cgatctccat gagcctcagt ttccatacgt      480

gtaaaagggg gatgatcata gcatctacca tgtgggcttg cagtgcagag tatttgaatt      540

agacacagaa cagtgaggat caggatggcc tctcacccac ctgcctttct gcccagctgc      600


<210>  140
<211>  250
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_25kb AAVS1 5'HA for Cas9_P1 and Cas9_N2

<400>  140
tagccacctc tccatcctct tgctttcttt gcctggacac cccgttctcc tgtggattcg       60

ggtcacctct cactcctttc atttgggcag ctcccctacc ccccttacct ctctagtctg      120

tgctagctct tccagccccc tgtcatggca tcttccaggg gtccgagagc tcagctagtc      180

ttcttcctcc aacccgggcc cctatgtcca cttcaggaca gcatgtttgc tgcctccagg      240

gatcctgtgt                                                             250


<210>  141
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb AAVS1 5'HA for Cas9_P1 and Cas9_N2

<400>  141
aggttccgtc ttcctccact ccctcttccc cttgctctct gctgtgttgc tgcccaagga       60

tgctctttcc ggagcacttc cttctcggcg ctgcaccacg tgatgtcctc tgagcggatc      120

ctccccgtgt ctgggtcctc tccgggcatc tctcctccct cacccaaccc catgccgtct      180

tcactcgctg ggttcccttt tccttctcct tctggggcct gtgccatctc tcgtttctta      240

ggatggcctt ctccgacgga tgtctccctt gcgtcccgcc tccccttctt gtaggcctgc      300

atcatcaccg tttttctgga caaccccaaa gtaccccgtc tccctggctt tagccacctc      360

tccatcctct tgctttcttt gcctggacac cccgttctcc tgtggattcg ggtcacctct      420

cactcctttc atttgggcag ctcccctacc ccccttacct ctctagtctg tgctagctct      480

tccagccccc tgtcatggca tcttccaggg gtccgagagc tcagctagtc ttcttcctcc      540

aacccgggcc cctatgtcca cttcaggaca gcatgtttgc tgcctccagg gatcctgtgt      600


<210>  142
<211>  250
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_25kb AAVS1 3'HA for Cas9_P1 and Cas9_N2

<400>  142
ctctggttct gggtactttt atctgtcccc tccaccccac agtggggcca ctagggacag       60

gattggtgac agaaaagccc catccttagg cctcctcctt cctagtctcc tgatattggg      120

tctaaccccc acctcctgtt aggcagattc cttatctggt gacacacccc catttcctgg      180

agccatctct ctccttgcca gaacctctaa ggtttgctta cgatggagcc agagaggatc      240

ctgggaggga                                                             250


<210>  143
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  0_6kb AAVS1 3'HA for Cas9_P1 and Cas9_N2

<400>  143
ctctggttct gggtactttt atctgtcccc tccaccccac agtggggcca ctagggacag       60

gattggtgac agaaaagccc catccttagg cctcctcctt cctagtctcc tgatattggg      120

tctaaccccc acctcctgtt aggcagattc cttatctggt gacacacccc catttcctgg      180

agccatctct ctccttgcca gaacctctaa ggtttgctta cgatggagcc agagaggatc      240

ctgggaggga gagcttggca gggggtggga gggaaggggg ggatgcgtga cctgcccggt      300

tctcagtggc caccctgcgc taccctctcc cagaacctga gctgctctga cgcggccgtc      360

tggtgcgttt cactgatcct ggtgctgcag cttccttaca cttcccaaga ggagaagcag      420

tttggaaaaa caaaatcaga ataagttggt cctgagttct aactttggct cttcaccttt      480

ctagtcccca atttatattg ttcctccgtg cgtcagtttt acctgtgaga taaggccagt      540

agccagcccc gtcctggcag ggctgtggtg aggagggggg tgtccgtgtg gaaaactccc      600


<210>  144
<211>  274
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Selection marker LNGFR RQR8 EGFRt LNGFRt protein sequence  

<400>  144

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg 
        


<210>  145
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  RQR8 protein sequence

<400>  145

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
145                 150                 155         


<210>  146
<211>  357
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  EGFRt with GM_CSFR signal peptide

<400>  146

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  147
<211>  347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  MND promoter

<400>  147
gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc       60

cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt      120

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc      180

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc      240

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc      300

tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatc                    347


<210>  148
<211>  523
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PGK promoter

<400>  148
ccacggggtt ggggttgcgc cttttccaag gcagccctgg gtttgcgcag ggacgcggct       60

gctctgggcg tggttccggg aaacgcagcg gcgccgaccc tgggtctcgc acattcttca      120

cgtccgttcg cagcgtcacc cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc      180

ttcctgctcc gcccctaagt cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac      240

aaacggaagc cgcacgtctc actagtaccc tcgcagacgg acagcgccag ggagcaatgg      300

cagcgcgccg accgcgatgg gctgtggcca atagcggctg ctcagcgggg cgcgccgaga      360

gcagcggccg ggaaggggcg gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt      420

tcctgcccgc gcggtgttcc gcattctgca agcctccgga gcgcacgtcg gcagtcggct      480

ccctcgttga ccgaatcacc gacctctctc cccaggggga tcc                        523


<210>  149
<211>  231
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  EF1 promoter

<400>  149
aggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg       60

gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag      120

tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc      180

agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac a               231


<210>  150
<211>  135
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  SV40 polyA

<400>  150
tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat       60

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg      120

gaggtttttt aaagc                                                       135


<210>  151
<211>  898
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3'UTR of FOXP3

<400>  151
cctcaagatc aaggaaagga ggatggacga acaggggcca aactggtggg aggcagaggt       60

ggtgggggca gggatgatag gccctggatg tgcccacagg gaccaagaag tgaggtttcc      120

actgtcttgc ctgccagggc ccctgttccc ccgctggcag ccaccccctc ccccatcata      180

tcctttgccc caaggctgct cagaggggcc ccggtcctgg ccccagcccc cacctccgcc      240

ccagacacac cccccagtcg agccctgcag ccaaacagag ccttcacaac cagccacaca      300

gagcctgcct cagctgctcg cacagattac ttcagggctg gaaaagtcac acagacacac      360

aaaatgtcac aatcctgtcc ctcactcaac acaaacccca aaacacagag agcctgcctc      420

agtacactca aacaacctca aagctgcatc atcacacaat cacacacaag cacagccctg      480

acaacccaca caccccaagg cacgcaccca cagccagcct cagggcccac aggggcactg      540

tcaacacagg ggtgtgccca gaggcctaca cagaagcagc gtcagtaccc tcaggatctg      600

aggtcccaac acgtgctcgc tcacacacac ggcctgttag aattcacctg tgtatctcac      660

gcatatgcac acgcacagcc ccccagtggg tctcttgagt cccgtgcaga cacacacagc      720

cacacacact gccttgccaa aaataccccg tgtctcccct gccactcacc tcactcccat      780

tccctgagcc ctgatccatg cctcagctta gactgcagag gaactactca tttatttggg      840

atccaaggcc cccaacccac agtaccgtcc ccaataaact gcagccgagc tccccaca        898


<210>  152
<211>  822
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  LNGFR coding sequence without stop codon

<400>  152
atgggggcag gtgccaccgg acgagccatg gacgggccgc gcctgctgct gttgctgctt       60

ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacacagc      120

ggtgagtgct gcaaagcctg caacctgggc gagggtgtgg cccagccttg tggagccaac      180

cagaccgtgt gtgagccctg cctggacagc gtgacgttct ccgacgtggt gagcgcgacc      240

gagccgtgca agccgtgcac cgagtgcgtg gggctccaga gcatgtcggc gccgtgcgtg      300

gaggccgacg acgccgtgtg ccgctgcgcc tacggctact accaggatga gacgactggg      360

cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtgttctc ctgccaggac      420

aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attccgacga ggccaaccac      480

gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct ccgcgagtgc      540

acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac acggtccaca      600

cccccagagg gctcggacag cacagccccc agcacccagg agcctgaggc acctccagaa      660

caagacctca tagccagcac ggtggcaggt gtggtgacca cagtgatggg cagctcccag      720

cccgtggtga cccgaggcac caccgacaac ctcatccctg tctattgctc catcctggct      780

gctgtggttg tgggtcttgt ggcctacata gccttcaaga gg                         822


<210>  153
<211>  1899
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  uDISC uCISC_FRB nucleotide sequence coding sequence only codon 
       optimized

<400>  153
atgcctctgg gcctgctgtg gctgggcctg gccctgctgg gcgccctgca cgcccaggcc       60

ggcgtgcagg tggagacaat ctccccaggc gacggacgca cattccctaa gcggggccag      120

acctgcgtgg tgcactatac aggcatgctg gaggatggca agaagtttga cagctcccgg      180

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      240

gagggcgtgg cccagatgtc tgtgggccag agggccaagc tgaccatcag cccagactac      300

gcctatggag caacaggcca cccaggaatc atcccacctc acgccaccct ggtgttcgat      360

gtggagctgc tgaagctggg cgagggaggg tcacctggat ccaacacatc aaaagagaac      420

ccctttctgt tcgcattgga ggccgtagtc atatctgttg gatccatggg acttattatc      480

tccctgttgt gtgtgtactt ctggctggaa cggactatgc ccaggatccc cacgctcaag      540

aatctggaag atctcgtcac agaataccat ggtaatttca gcgcctggag cggagtctct      600

aagggtctgg ccgaatccct ccaacccgat tattctgaac ggttgtgcct cgtatccgaa      660

ataccaccaa aaggcggggc tctgggtgag ggcccagggg cgagtccgtg caatcaacac      720

agcccgtatt gggcccctcc ttgttatacg ttgaagcccg aaactggaag cggagctact      780

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatggcactg      840

cccgtgaccg ccctgctgct gcctctggcc ctgctgctgc acgcagcccg gcctatcctg      900

tggcacgaga tgtggcacga gggcctggag gaggccagca ggctgtattt tggcgagcgc      960

aacgtgaagg gcatgttcga ggtgctggag cctctgcacg ccatgatgga gagaggccca     1020

cagaccctga aggagacatc ctttaaccag gcctatggac gggacctgat ggaggcacag     1080

gagtggtgca gaaagtacat gaagtctggc aatgtgaagg acctgctgca ggcctgggat     1140

ctgtactatc acgtgtttcg gagaatctcc aagccagcag ctctcggcaa agacacgatt     1200

ccgtggcttg ggcatctgct cgttgggctg agcggtgcgt ttggtttcat catcttggtc     1260

tatctcttga tcaattgcag aaatacaggc ccttggctga aaaaagtgct caagtgtaat     1320

acccccgacc caagcaagtt cttctcccag ctttcttcag agcatggagg cgatgtgcag     1380

aaatggctct cttcaccttt tccctcctca agcttctccc cgggagggct ggcgcccgag     1440

atttcacctc ttgaggtact tgaacgagac aaggttaccc aacttctcct tcaacaggat     1500

aaggtacccg aacctgcgag ccttagcttg aatacagacg cttatctctc actgcaggaa     1560

ctgcaaggat ctggtgctac taatttttct cttttgaagc aagctggaga tgttgaagag     1620

aaccccggtc cggagatgtg gcatgagggt ctggaagaag cgtctcgact gtactttggt     1680

gagcgcaatg tgaagggcat gtttgaagtc ctcgaacccc ttcatgccat gatggaacgc     1740

ggaccccaga ccttgaagga gacaagtttt aaccaagctt acggaagaga cctgatggaa     1800

gcccaggaat ggtgcaggaa atacatgaaa agcgggaatg tgaaggactt gctccaagcg     1860

tgggacctgt actatcatgt ctttaggcgc attagtaag                            1899


<210>  154
<211>  633
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  uDISC uCISC_FRB amino acid sequence

<400>  154

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu 
        115                 120                 125             


Gly Gly Ser Pro Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
    130                 135                 140                 


Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile 
145                 150                 155                 160 


Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile 
                165                 170                 175     


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
            180                 185                 190         


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
        195                 200                 205             


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
    210                 215                 220                 


Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His 
225                 230                 235                 240 


Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr Gly 
                245                 250                 255     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            260                 265                 270         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        275                 280                 285             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ile Leu Trp His Glu Met 
    290                 295                 300                 


Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg 
305                 310                 315                 320 


Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met 
                325                 330                 335     


Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr 
            340                 345                 350         


Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys 
        355                 360                 365             


Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His 
    370                 375                 380                 


Val Phe Arg Arg Ile Ser Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile 
385                 390                 395                 400 


Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe 
                405                 410                 415     


Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp 
            420                 425                 430         


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
        435                 440                 445             


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
    450                 455                 460                 


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
465                 470                 475                 480 


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
                485                 490                 495     


Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Leu Asn Thr 
            500                 505                 510         


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
545                 550                 555                 560 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
                565                 570                 575     


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
            580                 585                 590         


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
        595                 600                 605             


Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
    610                 615                 620                 


Tyr His Val Phe Arg Arg Ile Ser Lys 
625                 630             


<210>  155
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  NHEJ_F

<400>  155
cacgtgtgac tcctttccc                                                    19


<210>  156
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  NHEJ_R

<400>  156
cccagtgcca cagtaaaggt                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  FAM_NHEJ probe

<400>  157
agggccgaga tcttcgaggc                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Control_F

<400>  158
cgacacttca ccccttttct                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Control_R

<400>  159
ctccccaatg tgcctatgag                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  HEX_Control probe

<400>  160
gtggcggtga ctgggatggc                                                   20


<210>  161
<211>  7219
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3232_pAAV_FOXP3_0_8HA_ATG_FOXP3cDNA_WPRE3_pA_T3 specific

<400>  161
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg       60

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc      720

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc      780

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      840

taatgcagct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      900

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      960

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc     1020

ggccgcattt aatgccagac tcttcatgtc tatctacacc tgcacttttg cacccaatcc     1080

aactccccgc catgtccccc atctcaggta atgtcagctc ggtccttcca gctgctcaag     1140

ctaaaaccca tgtcactttg actctccctc ttgcccacta catccaagct gctagcactg     1200

ctcctgatcc agcttcagat taagtctcag aatctaccca cttctcgcct tctccactgc     1260

caccagccca ttctgtgcca gcatcatcac ttgccaggac tgttacaata gcctcctcac     1320

tagccccact cacagcagcc agatgaatct tttgagtcca tgcctagtca ctggggcaaa     1380

ataggactcc gaggagaaag tccgagacca gctccggcaa gatgagcaaa cacagcctgt     1440

gcagggtgca gggagggcta gaggcctgag gcttgaaaca gctctcaagt ggagggggaa     1500

acaaccattg ccctcataga ggacacatcc acaccagggc tgtgctagcg tgggcaggca     1560

agccaggtgc tggacctctg cacgtggggc atgtgtgggt atgtacatgt acctgtgttc     1620

ttggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtctaga gctggggtgc aactatgggg     1680

cccctcggga catgtcccag ccaatgcctg ctttgaccag aggagtgtcc acgtggctca     1740

ggtggtcgag tatctcatac cgccctagca cacgtgtgac tcctttcccc tattgtctac     1800

gcagcctgcc cttggacaag gacccgatgc ctaatcctcg gcctggaaag cctagcgctc     1860

cttctcttgc tctgggacct tctcctggcg cctctccatc ttggagagcc gctcctaaag     1920

ccagcgatct gctgggagct agaggacctg gcggcacatt tcagggcaga gatcttagag     1980

gcggagccca cgctagctcc tccagcctta atcctatgcc tcctagccag ctccagctgc     2040

ctacactgcc tctggttatg gtggctccta gcggagctag actgggccct ctgcctcatc     2100

tgcaagctct gctgcaggac agaccccact tcatgcacca gctgagcacc gtggatgccc     2160

acgcaagaac acctgtgctg caggttcacc ctctggaatc cccagccatg atcagcctga     2220

cacctccaac aacagccacc ggcgtgttca gcctgaaagc cagacctgga ctgcctcctg     2280

gcatcaatgt ggccagcctg gaatgggtgt ccagagaacc tgctctgctg tgcacattcc     2340

ccaatccaag cgctcccaga aaggacagca cactgtctgc cgtgcctcag agcagctatc     2400

ccctgcttgc taacggcgtg tgcaagtggc ctggatgcga gaaggtgttc gaggaacccg     2460

aggacttcct gaagcactgc caggccgatc atctgctgga cgagaaaggc agagcccagt     2520

gtctgctcca gcgcgagatg gtgcagtctc tggaacagca gctggtcctg gaaaaagaaa     2580

agctgagcgc catgcaggcc cacctggccg gaaaaatggc cctgacaaag gccagcagcg     2640

tggcctcttc tgataagggc agctgctgca ttgtggccgc tggatctcag ggacctgtgg     2700

ttcctgcttg gagcggacct agagaggccc ctgattctct gtttgccgtg cggagacacc     2760

tgtggggctc tcacggcaac tctactttcc ccgagttcct gcacaacatg gactacttca     2820

agttccacaa catgcggcct ccattcacct acgccacact gatcagatgg gccattctgg     2880

aagcccctga gaagcagaga accctgaacg agatctacca ctggtttacc cggatgttcg     2940

ccttcttccg gaatcaccct gccacctgga agaacgccat ccggcacaat ctgagcctgc     3000

acaagtgctt cgtgcgcgtg gaatctgaga aaggcgccgt gtggacagtg gacgagctgg     3060

aattcagaaa gaagagaagc cagcggccta gccggtgcag caatcctaca cctggacctt     3120

gaaagcttga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     3180

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     3240

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggtta gttcttgcca     3300

cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca     3360

ctgacaattc cgtgggtcga ctgctttatt tgtgaaattt gtgatgctat tgctttattt     3420

gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt     3480

caggttcagg gggagatgtg ggaggttttt taaagcacta gtcgagatct tcgaggcggg     3540

gcccatgcct cctcttcttc cttgaacccc atgccaccat cgcagctgca ggtgaggccc     3600

tgggcccagg atggggcagg cagggtgggg tacctggacc tacaggtgcc gacctttact     3660

gtggcactgg gcgggagggg ggctggctgg ggcacaggaa gtggtttctg ggtcccaggc     3720

aagtctgtga cttatgcaga tgttgcaggg ccaagaaaat ccccacctgc caggcctcag     3780

agattggagg ctctccccga cctcccaatc cctgtctcag gagaggagga ggccgtattg     3840

tagtcccatg agcatagcta tgtgtcccca tccccatgtg acaagagaag aggactgggg     3900

ccaagtaggt gaggtgacag ggctgaggcc agctctgcaa cttattagct gtttgatctt     3960

taaaaagtta ctcgatctcc atgagcctca gtttccatac gtgtaaaagg gggatgatca     4020

tagcatctac catgtgggct tgcagtgcag agtatttgaa ttagacacag aacagtgagg     4080

atcaggatgg cctctcaccc acctgccttt ctgcccagct gcccacactg cccctagtca     4140

tggtggcacc ctccggggca cggctgggcc ccttgcccca cttacaggca ctcctccagg     4200

acaggccaca tttcatgcac caggtatgga cggtgaatgg gcagggagga gggagcaggt     4260

gggagaactg tggggagggg ccccgagtca ggctgaaccg gatcctacgt agataagtag     4320

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     4380

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4440

gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg     4500

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgat tccgttgcaa     4560

tggctggcgg taatattgtt ctggatatta ccagcaaggc cgatagtttg agttcttcta     4620

ctcaggcaag tgatgttatt actaatcaaa gaagtattgc gacaacggtt aatttgcgtg     4680

atggacagac tcttttactc ggtggcctca ctgattataa aaacacttct caggattctg     4740

gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct gtttagctcc cgctctgatt     4800

ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac catagtacgc gccctgtagc     4860

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     4920

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     4980

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     5040

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag     5100

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     5160

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     5220

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac     5280

aaaatattaa cgtttacaat ttaaatattt gcttatacaa tcttcctgtt tttggggctt     5340

ttctgattat caaccggggt acatatgatt gacatgctag ttttacgatt accgttcatc     5400

gattctcttg tttgctccag actctcaggc aatgacctga tagcctttgt agagacctct     5460

caaaaatagc taccctctcc ggcatgaatt tatcagctag aacggttgaa tatcatattg     5520

atggtgattt gactgtctcc ggcctttctc acccgtttga atctttacct acacattact     5580

caggcattgc atttaaaata tatgagggtt ctaaaaattt ttatccttgc gttgaaataa     5640

aggcttctcc cgcaaaagta ttacagggtc ataatgtttt tggtacaacc gatttagctt     5700

tatgctctga ggctttattg cttaattttg ctaattcttt gccttgcctg tatgatttat     5760

tggatgttgg aatcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     5820

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     5880

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     5940

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     6000

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     6060

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     6120

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     6180

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     6240

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     6300

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     6360

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     6420

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     6480

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6540

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6600

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6660

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6720

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     6780

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6840

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6900

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6960

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     7020

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     7080

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     7140

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     7200

ccactgagcg tcagacccc                                                  7219


