                         SEQUENCE LISTING

<110>  Janssen Pharmaceutica N.V.
 
<120>  Glucagon Like Peptide 1 (GLP-1) Fusion Peptide Coupled 
Cyclic Peptide Tyrosine Tyrosine Conjugates and Uses Thereof

<130>  PRD3465

<150>  PCT/US2018/029284
<151>  2018-04-25

<150>  US 62/662,313
<151>  2018-04-25

<160>  274   

<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the Ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein Cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  1

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Leu
<222>  (29)..(29)
<223>  Leu, wherien Leu is a norleucine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a N-Me chemical modification

<400>  2

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Leu Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Leu
<222>  (29)..(29)
<223>  Leu, wherein leu is a norleucine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  3

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Leu Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  4
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Glu
<222>  (30)..(30)
<223>  Glu with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  4

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Glu Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  5
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG6-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  5

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  6
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  6

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  7

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  8
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Gln
<222>  (33)..(33)
<223>  Gln with a N-Me chemical modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  8

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  9
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me and a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  9

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  10
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  10

Ala Ile Arg Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Trp Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  11

Ile Arg Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Trp Cys Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Lys
<222>  (1)..(1)
<223>  Lys with a cyclic modification

<220>
<221>  Lys
<222>  (8)..(8)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (32)..(32)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (33)..(33)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  12

Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn Arg 
1               5                   10                  15      


Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg Gln Arg 
            20                  25                  30          


Tyr 
    


<210>  13
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Leu
<222>  (29)..(29)
<223>  Leu, wherein the leu is a norleucine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  13

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Leu Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  14
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a PEG-8-triazolyl-CH2CH2CO-PEG4-AcBr chemical 
       modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a (R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a (R35, Y36) chemical modification

<400>  14

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (22)..(22)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  15

Ala Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Lys Leu Arg His Tyr Leu Asn Leu Cys Val Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (21)..(21)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  16

Ala Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Lys Ser Leu Arg His Tyr Leu Asn Leu Cys Val Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (6)..(6)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  17

Ala Ile Lys Pro Glu Lys Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Val Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  18
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  18

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  19
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  19

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  20
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  20

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  21
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  21

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  22
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  22

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  23
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG12-AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  23

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  24
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Glu
<222>  (29)..(29)
<223>  Glu with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  24

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Glu Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  25
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG24-AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  25

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  26
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  26

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  27
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  27

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  28
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  28

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  29
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  29

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  30
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  30

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  31
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  31

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  32
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with an AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  32

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  33
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Glu
<222>  (29)..(29)
<223>  Glu with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  33

Gly Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Glu Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  34
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino-butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys, wherein cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  34

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  35
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a N-Me chemical modification

<400>  35

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  36
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  36

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  37
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a N-Me chemical modification

<400>  37

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  38
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  38

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ile
<222>  (1)..(1)
<223>  Ile with a cyclic modification

<220>
<221>  Lys
<222>  (9)..(9)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (28)..(28)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (33)..(33)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (34)..(34)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  39

Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  40
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  40

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  41

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  42

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  43

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  44
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  44

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  45
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys is a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine is a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  45

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  46

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  47

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  48
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a delta-amino valeric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  48

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  49
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a delta-amino valeric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  49

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  50
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a delta-amino valeric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  50

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  51
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a delta-amino valeric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  51

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  52
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  52

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  53
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  53

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  54
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic PYY Peptide Compound


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a AcBr chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  54

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  55
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  56
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 (7-36)

<400>  56

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  57
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 (7-37)

<400>  57

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210>  58
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extendin 4 (1-39)

<400>  58

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  59
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extendin 4 (1-28)

<400>  59

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn 
            20                  25              


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-1

<400>  60

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala 
1               5                   10                  15      


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-2

<400>  61

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala 
1               5                   10                  15      


<210>  62
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-3

<400>  62

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala 
            20      


<210>  63
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-4

<400>  63

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala 
            20                  25  


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-5

<400>  64

Ala Pro Ala Pro Ala Pro 
1               5       


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-6

<400>  65

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser 
1               5                   10                  


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-7

<400>  66

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Gly Ser 
            20                  


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-8

<400>  67

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  68
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-9

<400>  68

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  69
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-10

<400>  69

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-11

<400>  70

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
1               5                   10                  15  


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-12

<400>  71

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala 
            20  


<210>  72
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-13

<400>  72

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Ala 
            20      


<210>  73
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-14

<400>  73

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala 
            20                  25      


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-15

<400>  74

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-16

<400>  75

Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Ala 
1               5                   10                  15      


<210>  76
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-17

<400>  76

Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly 
1               5                   10                  15      


Gly Gly Gly His Ala 
            20      


<210>  77
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-18

<400>  77

Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly 
1               5                   10                  15      


Gly Gly Gly His Gly Gly Gly Gly His Ala 
            20                  25      


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-19

<400>  78

Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Ala 
1               5                   10                  15      


<210>  79
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-20

<400>  79

Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Gly Pro Ala 
            20      


<210>  80
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-21

<400>  80

Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Gly Pro Gly Gly Gly Gly Pro Ala 
            20                  25      


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-22

<400>  81

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-23

<400>  82

Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ala Pro 
            20      


<210>  83
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1-24

<400>  83

Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ala Pro Ala 
            20          


<210>  84
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 1

<400>  84

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  85
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 2

<400>  85

Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        35                  40                  45              


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    210                 215                 220                 


<210>  86
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 3

<400>  86

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  87
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 4

<400>  87

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    210                 215                 220     


<210>  88
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 5

<400>  88

Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        35                  40                  45              


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    210                 215                 220                 


Lys 
225 


<210>  89
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 6

<400>  89

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  90
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-Fc Region Peptide 7

<400>  90

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-1

<400>  91

Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
1               5                   10                  15      


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-2

<400>  92

Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
1               5                   10                  15  


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-3

<400>  93

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Glu 
1               5                   10                  15      


Pro 
    


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-4

<400>  94

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro 
1               5                   10                  


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-5

<400>  95

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Cys 
1               5                   10                  15      


Ala 
    


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-6

<400>  96

Gly Gly Gly Gly Ala Tyr Cys Ala Lys Tyr Asp Gly Cys Tyr Gly Glu 
1               5                   10                  15      


Leu Asp Phe Trp Cys Gln 
            20          


<210>  97
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-7

<400>  97

Gly Gly Gly Gly Ala Tyr Ser Ala Lys Tyr Asp Gly Cys Tyr Gly Glu 
1               5                   10                  15      


Leu Asp Phe Trp Gly Gln 
            20          


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-8

<400>  98

Ala Ala Ala Cys Pro Glu Glu Glu 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-9

<400>  99

Ala Ala Ala Glu Glu Pro Cys Ala 
1               5               


<210>  100
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-10

<400>  100

Ala Pro Ala Pro Ala Pro Ala Pro Cys Ala Pro Arg Arg Arg 
1               5                   10                  


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-11

<400>  101

Ala Pro Ala Pro Glu Glu Pro Cys Ala 
1               5                   


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-12

<400>  102

Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys Glu Glu Glu 
1               5                   10                  15      


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-13

<400>  103

Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Glu 
1               5                   10                  15      


Pro 
    


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-14

<400>  104

Ala Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Cys Ala 
1               5                   10                  


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-15

<400>  105

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys 
1               5                   10                  15      


Ala 
    


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-16

<400>  106

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
1               5                   10          


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-17

<400>  107

Ala Ser Gly Ser Pro Pro Pro Pro Pro Pro Glu Pro Glu Pro Cys Ala 
1               5                   10                  15      


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-18

<400>  108

Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Pro 
1               5                   10                  15      


Glu 
    


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-19

<400>  109

Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
1               5                   10                  15      


<210>  110
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-20

<400>  110

Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Glu Glu Glu 
1               5                   10                  15      


Pro Cys Ala 
            


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-21

<400>  111

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
1               5                   10                  15      


Ala 
    


<210>  112
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2-22

<400>  112

Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu 
1               5                   10                  15      


Glu Ala Cys Ala 
            20  


<210>  113
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 1

<400>  113

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  114
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 2

<400>  114

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  115
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 3

<400>  115

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro 
    290                 


<210>  116
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 4

<400>  116

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro 
        275                 280                 285     


<210>  117
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 5

<400>  117

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro 
        275                 280                 285     


<210>  118
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 6

<400>  118

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Cys Pro 
    290     


<210>  119
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 7

<400>  119

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Cys Pro 
    290     


<210>  120
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 8

<400>  120

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly 
        275                 280                 285             


Gly Ala Cys Ala 
    290         


<210>  121
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 9

<400>  121

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly 
        275                 280                 285             


Gly Ala Cys Ala 
    290         


<210>  122
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 10

<400>  122

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ala Gly Gly Gly 
        275                 280                 285             


Gly Ala Gly Gly Gly Gly Ala Cys Ala 
    290                 295         


<210>  123
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 11

<400>  123

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Cys 
        275                 280                 285             


Ala 
    


<210>  124
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 12

<400>  124

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Cys 
        275                 280                 285             


Ala 
    


<210>  125
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 13

<400>  125

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
        275                 280                 285             


Gly Gly Gly Ala Cys Ala 
    290                 


<210>  126
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 14

<400>  126

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
        275                 280                 285             


Gly Gly Gly Ala Cys Ala 
    290                 


<210>  127
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 15

<400>  127

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ala Tyr Cys Ala Lys Tyr Asp Gly Cys 
        275                 280                 285             


Tyr Gly Glu Leu Asp Phe Trp Cys Gln 
    290                 295         


<210>  128
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 16

<400>  128

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Gly Gly Gly Gly Ala Tyr Cys Ala Lys Tyr Asp 
        275                 280                 285             


Gly Cys Tyr Gly Glu Leu Asp Phe Trp Cys Gln 
    290                 295                 


<210>  129
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 17

<400>  129

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ala Tyr Ser Ala Lys Tyr Asp Gly Cys 
        275                 280                 285             


Tyr Gly Glu Leu Asp Phe Trp Gly Gln 
    290                 295         


<210>  130
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 18

<400>  130

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Gly Gly Gly Gly Ala Tyr Ser Ala Lys Tyr Asp 
        275                 280                 285             


Gly Cys Tyr Gly Glu Leu Asp Phe Trp Gly Gln 
    290                 295                 


<210>  131
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 19

<400>  131

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro 
        275                 280                 285             


Cys Ala 
    290 


<210>  132
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 20

<400>  132

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro 
        275                 280                 285             


Cys Ala 
    290 


<210>  133
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 21

<400>  133

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280                 285         


<210>  134
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 22

<400>  134

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly 
        35                  40                  45              


Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
    290                 295             


<210>  135
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 23

<400>  135

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
    290                 295             


<210>  136
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 24

<400>  136

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  137
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 25

<400>  137

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  138
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 26

<400>  138

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  139
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 27

<400>  139

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  140
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 28

<400>  140

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Glu 
        275                 280                 285             


Pro 
    


<210>  141
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 29

<400>  141

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Glu 
        275                 280                 285             


Pro 
    


<210>  142
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 30

<400>  142

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Cys Pro Glu Glu Pro 
    290                 


<210>  143
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 31

<400>  143

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Cys Pro Glu Glu Pro 
    290                 


<210>  144
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 32

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Ala Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
    130                 135                 140                 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro 
            260                 265                 270         


Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280 


<210>  145
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 33

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Ala Ser 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Cys Pro Pro Cys 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    50                  55                  60                  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
65                  70                  75                  80  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
                85                  90                  95      


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            100                 105                 110         


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        115                 120                 125             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    130                 135                 140                 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
145                 150                 155                 160 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
                165                 170                 175     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            180                 185                 190         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        195                 200                 205             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    210                 215                 220                 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
225                 230                 235                 240 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                245                 250                 255     


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro 
            260                 265                 270         


Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280         


<210>  146
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 34

<400>  146

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys 
        275                 280                 285             


Ala 
    


<210>  147
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 35

<400>  147

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu 
        275                 280                 285             


Pro Cys Ala 
    290     


<210>  148
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 36

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Ala Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys Pro Pro 
        35                  40                  45              


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    50                  55                  60                  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
65                  70                  75                  80  


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                85                  90                  95      


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            100                 105                 110         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        115                 120                 125             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    130                 135                 140                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                165                 170                 175     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            180                 185                 190         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        195                 200                 205             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    210                 215                 220                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
225                 230                 235                 240 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                245                 250                 255     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280             


<210>  149
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 37

<400>  149

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu 
        275                 280                 285             


Glu Pro Cys Ala 
    290         


<210>  150
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 38

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Ala Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
    50                  55                  60                  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
65                  70                  75                  80  


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
                85                  90                  95      


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            100                 105                 110         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
        115                 120                 125             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    130                 135                 140                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
145                 150                 155                 160 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                165                 170                 175     


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            180                 185                 190         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        195                 200                 205             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    210                 215                 220                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
225                 230                 235                 240 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
                245                 250                 255     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
            260                 265                 270         


Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro 
        275                 280                 285             


Cys Ala 
    290 


<210>  151
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 39

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Ala Ser 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu 
        275                 280                 285             


Glu Pro Cys Ala 
    290         


<210>  152
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 40

<400>  152

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala 
            260                 265                 270         


Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280     


<210>  153
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 41

<400>  153

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu 
        275                 280                 285             


Pro Cys Ala 
    290     


<210>  154
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 42

<400>  154

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Ala Pro Ala Pro Glu Pro Glu Pro Glu Pro Cys 
        275                 280                 285             


Ala 
    


<210>  155
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 43

<400>  155

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Cys Ala 
    290     


<210>  156
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 44

<400>  156

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala 
            260                 265                 270         


Pro Glu Pro Glu Pro Glu Pro Cys Ala 
        275                 280     


<210>  157
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 45

<400>  157

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys Glu Glu 
        275                 280                 285             


Glu 
    


<210>  158
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 46

<400>  158

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Glu Glu Glu 
    290     


<210>  159
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 47

<400>  159

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Cys Glu Glu Glu 
    290         


<210>  160
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 48

<400>  160

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Cys Glu Glu Glu 
        275                 280     


<210>  161
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 49

<400>  161

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu 
        275                 280                 285             


Glu Pro 
    290 


<210>  162
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 50

<400>  162

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  163
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 51

<400>  163

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Cys Pro Glu Glu Pro 
    290             


<210>  164
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 52

<400>  164

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Cys Pro Glu Glu Pro 
        275                 280         


<210>  165
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 53

<400>  165

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Cys Pro Pro 
        35                  40                  45              


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    50                  55                  60                  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
65                  70                  75                  80  


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                85                  90                  95      


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            100                 105                 110         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        115                 120                 125             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    130                 135                 140                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                165                 170                 175     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            180                 185                 190         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        195                 200                 205             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    210                 215                 220                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
225                 230                 235                 240 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                245                 250                 255     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280             


<210>  166
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 54

<400>  166

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Pro Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    50                  55                  60                  


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
65                  70                  75                  80  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                85                  90                  95      


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            100                 105                 110         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        115                 120                 125             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    130                 135                 140                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
145                 150                 155                 160 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                165                 170                 175     


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
            180                 185                 190         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        195                 200                 205             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    210                 215                 220                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
225                 230                 235                 240 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
                245                 250                 255     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            260                 265                 270         


Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu 
        275                 280                 285             


Glu Glu Pro Cys Ala 
    290             


<210>  167
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 55

<400>  167

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        35                  40                  45              


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
    130                 135                 140                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu 
            260                 265                 270         


Glu Glu Pro Cys Ala 
        275         


<210>  168
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 56

<400>  168

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Cys Pro Pro 
        35                  40                  45              


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    50                  55                  60                  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
65                  70                  75                  80  


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                85                  90                  95      


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            100                 105                 110         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        115                 120                 125             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    130                 135                 140                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                165                 170                 175     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            180                 185                 190         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        195                 200                 205             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    210                 215                 220                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
225                 230                 235                 240 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                245                 250                 255     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280             


<210>  169
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 57

<400>  169

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Pro Ala Pro Ala Pro Cys Pro Pro 
        35                  40                  45              


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    50                  55                  60                  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
65                  70                  75                  80  


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                85                  90                  95      


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            100                 105                 110         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        115                 120                 125             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    130                 135                 140                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                165                 170                 175     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            180                 185                 190         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        195                 200                 205             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    210                 215                 220                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
225                 230                 235                 240 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                245                 250                 255     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala 
            260                 265                 270         


Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280             


<210>  170
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 58

<400>  170

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Pro Ala Pro Glu Glu Pro Cys Ala 
        275                 280         


<210>  171
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 59

<400>  171

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ala Ala Glu Glu Pro Cys Ala 
        275                 280     


<210>  172
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 60

<400>  172

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Pro Ala Pro Ala Pro Ala Pro Cys Ala Pro Arg Arg Arg 
        275                 280                 285         


<210>  173
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 61

<400>  173

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ala Ala Cys Pro Glu Glu Glu 
        275                 280     


<210>  174
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 62

<400>  174

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
        275                 280                 285             


Ala 
    


<210>  175
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 63

<400>  175

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Glu Glu Glu Pro Cys Ala 
    290                 295         


<210>  176
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 64

<400>  176

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Glu Ser Lys Tyr 
    50                  55                  60                  


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            100                 105                 110         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        275                 280                 285             


Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys 
    290                 295                 300                 


Ala 
305 


<210>  177
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 65

<400>  177

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
145                 150                 155                 160 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Glu Glu Glu Pro Cys Ala 
    290                 


<210>  178
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 66

<400>  178

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
    290                 295                 300 


<210>  179
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 67

<400>  179

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys 
        275                 280                 285             


Ala 
    


<210>  180
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 68

<400>  180

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro 
        275                 280                 285             


Cys Ala 
    290 


<210>  181
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 69

<400>  181

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Pro Ala Pro Glu Glu Pro Cys Ala 
        275                 280                 285 


<210>  182
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 70

<400>  182

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Pro Ala Pro Glu Glu Pro Cys Ala 
        275                 280                 285 


<210>  183
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 71

<400>  183

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Pro Ala Pro 
        275                 280                 285             


Glu Glu Pro Cys Ala 
    290             


<210>  184
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 72

<400>  184

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ala Gly Gly Gly Gly 
        35                  40                  45              


Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Pro Ala Pro 
        275                 280                 285             


Glu Glu Pro Cys Ala 
    290             


<210>  185
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 73

<400>  185

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  186
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 74

<400>  186

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  187
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 75

<400>  187

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Gly Ala Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro 
    290                 295 


<210>  188
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 76

<400>  188

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly 
        35                  40                  45              


Gly Gly Pro Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro 
    290                 


<210>  189
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 77

<400>  189

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly 
        35                  40                  45              


Gly Gly His Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro 
    290                 


<210>  190
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 78

<400>  190

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Gly Gly Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro 
    290                 


<210>  191
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 79

<400>  191

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    130                 135                 140                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                165                 170                 175     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala 
    290                 295                 300                 


Pro Glu Glu Glu Pro Cys Ala 
305                 310     


<210>  192
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 80

<400>  192

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
        275                 280                 285 


<210>  193
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 81

<400>  193

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu 
        275                 280                 285             


Pro Cys Ala 
    290     


<210>  194
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 82

<400>  194

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu 
        275                 280                 285             


Glu Pro Cys Ala 
    290         


<210>  195
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 83

<400>  195

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Ala Ser Gly Ser Ala Pro Ala Pro Ala Pro Glu Glu 
        275                 280                 285             


Glu Pro Cys Ala 
    290         


<210>  196
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 84

<400>  196

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Lys Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu 
        275                 280                 285             


Pro Cys Ala 
    290     


<210>  197
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 85

<400>  197

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  198
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 86

<400>  198

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro 
    


<210>  199
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 87

<400>  199

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly 
        35                  40                  45              


Gly Gly Pro Gly Gly Gly Gly Pro Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro 
    290                 295 


<210>  200
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 88

<400>  200

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly 
        35                  40                  45              


Gly Gly His Gly Gly Gly Gly His Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro 
    290                 295 


<210>  201
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 89

<400>  201

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  202
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 90

<400>  202

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  203
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 91

<400>  203

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  204
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 92

<400>  204

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys 
        275                 280                 285             


Pro Glu Glu Pro 
    290         


<210>  205
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 93

<400>  205

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly 
        35                  40                  45              


Gly Gly Pro Gly Gly Gly Gly Pro Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295             


<210>  206
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 94

<400>  206

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly 
        35                  40                  45              


Gly Gly His Gly Gly Gly Gly His Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295             


<210>  207
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 95

<400>  207

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Gly Ala Ala Gly Pro Pro Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            180                 185                 190         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295             


<210>  208
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 96

<400>  208

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly 
        35                  40                  45              


Gly Gly Pro Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  209
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 97

<400>  209

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly His Gly Gly Gly Gly His Gly Gly Gly Gly His Gly Gly 
        35                  40                  45              


Gly Gly His Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  210
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 98

<400>  210

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Gly Gly Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  211
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 99

<400>  211

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro 
    290                 


<210>  212
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 100

<400>  212

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  213
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 101

<400>  213

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Cys Pro Glu Glu Pro 
    290                 295         


<210>  214
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 102

<400>  214

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Gly Gly Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    50                  55                  60                  


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
65                  70                  75                  80  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                85                  90                  95      


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            100                 105                 110         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    130                 135                 140                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
145                 150                 155                 160 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                165                 170                 175     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            180                 185                 190         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        195                 200                 205             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    210                 215                 220                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                245                 250                 255     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            260                 265                 270         


Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Glu Glu Glu Pro Cys Ala 
    290                 


<210>  215
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 103

<400>  215

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Glu Ser 
        35                  40                  45              


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                85                  90                  95      


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Leu Gly Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys 
        275                 280                 285             


Ala 
    


<210>  216
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 104

<400>  216

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280                 285             


<210>  217
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 105

<400>  217

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280                 285         


<210>  218
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 106

<400>  218

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys 
        275                 280                 285             


Ala 
    


<210>  219
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 107

<400>  219

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Cys 
        275                 280                 285             


Ala 
    


<210>  220
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 108

<400>  220

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro 
        275                 280                 285     


<210>  221
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 109

<400>  221

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Cys Pro Glu Glu 
        275                 280                 285             


Pro 
    


<210>  222
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 110

<400>  222

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Lys Gly Gly Gly Ala Pro Ala Pro Ala Pro Glu Glu Glu Pro Cys Ala 
        275                 280                 285             


<210>  223
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 111

<400>  223

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys 
        275                 280                 285             


Ala 
    


<210>  224
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 112

<400>  224

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        275                 280                 285             


Gly Gly Cys Ala 
    290         


<210>  225
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 1 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  225

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  226
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 1 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  226

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  227
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 1 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  227

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  228
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 1 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  228

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  229
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 24 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  229

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  230
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 24 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  230

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  231
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the alanine is a beta-alanine with a cyclic 
       modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 24 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  231

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  232
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 24 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  232

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  233
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 70 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  233

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  234
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 11 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  234

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  235
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 28 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  235

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  236
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 67 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  236

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  237
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 27 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  237

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  238
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 23 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  238

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  239
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 54 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a chemical modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  239

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  240
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 63 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  240

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  241
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 64 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  241

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  242
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 22 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  242

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  243
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 49 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  243

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  244
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a PEG24 GLP-1 fusion 34 chemical modification

<220>
<221>  Cys
<222>  (30)..(30)
<223>  Cys, wherein the cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  244

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Cys Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  245
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 35 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  245

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  246
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 65 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  246

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  247
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 45 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  247

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  248
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 40 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  248

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  249
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 40 chemical modification

<220>
<221>  Glu
<222>  (29)..(29)
<223>  Glu with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  249

Gly Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Glu Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  250
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 40 chemical modification

<220>
<221>  Glu
<222>  (29)..(29)
<223>  Glu with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  250

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Glu Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  251
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 19 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  251

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  252
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 8 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  252

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  253
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is a gamma amino-butyric acid with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 34 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys, wherein cys is a homocysteine with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  253

Xaa Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  254
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 42 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  254

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  255
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 59 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  255

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  256
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 60 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  256

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  257
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 61 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  257

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  258
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 63 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  258

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  259
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 63 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a psi-(R35, Y36) chemical modification

<220>
<221>  Tyr
<222>  (35)..(35)
<223>  Tyr with a psi-(R35, Y36) chemical modification

<400>  259

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  260
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Ala
<222>  (1)..(1)
<223>  Ala, wherein the ala is a beta-alanine with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 40 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  260

Ala Ile Lys Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  261
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 40 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  261

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  262
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion coupled cyclic PYY peptide conjugate


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly with a cyclic modification

<220>
<221>  Lys
<222>  (10)..(10)
<223>  Lys with a GLP-1 fusion 34 chemical modification

<220>
<221>  Cys
<222>  (29)..(29)
<223>  Cys with a cyclic modification

<220>
<221>  Arg
<222>  (34)..(34)
<223>  Arg with a N-Me chemical modification

<400>  262

Gly Ile Ser Pro Glu Ala Pro Gly Glu Lys Ala Ser Pro Glu Glu Leu 
1               5                   10                  15      


Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Cys Val Thr Arg 
            20                  25                  30          


Gln Arg Tyr 
        35  


<210>  263
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGE for GLPD30

<400>  263

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys 
            20  


<210>  264
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGE for GLPD31

<400>  264

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys 
1               5                   10          


<210>  265
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VVS peptide

<400>  265

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
1               5                   10                  15      


<210>  266
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YYA peptide

<400>  266

Tyr Tyr Ala Ser Leu Arg 
1               5       


<210>  267
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 113

<400>  267

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
        275                 280                 285         


<210>  268
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 114

<400>  268

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
        275                 280                 


<210>  269
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 115

<400>  269

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Gly Ser Cys Ala 
    290             


<210>  270
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 116

<400>  270

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
        275                 280                 285             


Cys Ala 
    290 


<210>  271
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 117

<400>  271

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
        275                 280                 


<210>  272
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 118

<400>  272

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Cys Ala 
    290                 295 


<210>  273
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 119

<400>  273

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr 
        35                  40                  45              


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                85                  90                  95      


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
        275                 280                 285             


Ala 
    


<210>  274
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 fusion 120

<400>  274

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    50                  55                  60                  


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                245                 250                 255     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            260                 265                 270         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Ala 
    290                 295                 300 


