                         SEQUENCE LISTING

<110>  UNICHEM LABORATORIES LTD
 
<120>  AN ENZYMATIC PROCESS FOR THE PREPARATION OF (R)-SITAGLIPTIN

<130>  IN201821015430

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Sequence

<400>  1
atggcgagca tggacaaggt gttcagcggt tactatgcgc gtcagaaact gctggagcgt       60

agcgataacc cgtttagcaa gggcatcgcg tacgtggaag gtaaactggt tctgccgagc      120

gacgcgcgta ttccgctgct ggatgagggc ttctacacca gcgacgcgac ctataccacc      180

ttccacgttt ggaacggcaa cgcgtttcgt ctgggtgacc acatcgagcg tctgtttagc      240

aacgcggaaa gcatccgtct gattccgccg ctgacccaag atgaggtgaa ggaaattgcg      300

ctggagctgg ttgcgaaaac cgagctgcgt gaagcgatgg ttaccgtgac catcacccgt      360

ggttatagca gcaccccgtt cgaacgtgac attaccaagc accgtccgca ggtgtacatg      420

agcgcgtgcc cgtatcaatg gatcgttccg tttgaccgta ttcgtgatgg cgttcacctg      480

atggtggcgc agagcgttcg tcgtaccccg cgtagcagca tcgatccgca ggtgaaaaac      540

ttccaatggg gtgacctgat ccgtgcgatt caagaaaccc acgatcgtgg ctttgaactg      600

ccgctgctgc tggactgcga taacctgctg gcggagggtc cgggtttcaa cgtggttgtg      660

atcaaggatg gtgttgttcg ttctccgggt cgtgcggcgc tgccgggcat cacccgtaaa      720

accgtgctgg agattgcgga aagcctgggt cacgaagcga tcctggcgga tattaccccg      780

gcggagctgt acgacgcgga tgaagtgctg ggttgcagca ccggtggcgg tgtttggccg      840

tttgttagcg tggacggcaa cagcatcagc gatggcgttc cgggtccgat tacccagagc      900

atcattcgtc gttactggga gctgaacgtg gaaccgagca gcctgctgac cccggttcaa      960

tatctcgag                                                              969


<210>  2
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified from Aspergillus fumigatus

<400>  2

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Tyr Thr Ser Asp Ala Thr Tyr Thr Thr Phe His Val Trp 
    50                  55                  60                  


Asn Gly Asn Ala Phe Arg Leu Gly Asp His Ile Glu Arg Leu Phe Ser 
65                  70                  75                  80  


Asn Ala Glu Ser Ile Arg Leu Ile Pro Pro Leu Thr Gln Asp Glu Val 
                85                  90                  95      


Lys Glu Ile Ala Leu Glu Leu Val Ala Lys Thr Glu Leu Arg Glu Ala 
            100                 105                 110         


Met Val Thr Val Thr Ile Thr Arg Gly Tyr Ser Ser Thr Pro Phe Glu 
        115                 120                 125             


Arg Asp Ile Thr Lys His Arg Pro Gln Val Tyr Met Ser Ala Cys Pro 
    130                 135                 140                 


Tyr Gln Trp Ile Val Pro Phe Asp Arg Ile Arg Asp Gly Val His Leu 
145                 150                 155                 160 


Met Val Ala Gln Ser Val Arg Arg Thr Pro Arg Ser Ser Ile Asp Pro 
                165                 170                 175     


Gln Val Lys Asn Phe Gln Trp Gly Asp Leu Ile Arg Ala Ile Gln Glu 
            180                 185                 190         


Thr His Asp Arg Gly Phe Glu Leu Pro Leu Leu Leu Asp Cys Asp Asn 
        195                 200                 205             


Leu Leu Ala Glu Gly Pro Gly Phe Asn Val Val Val Ile Lys Asp Gly 
    210                 215                 220                 


Val Val Arg Ser Pro Gly Arg Ala Ala Leu Pro Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Thr Val Leu Glu Ile Ala Glu Ser Leu Gly His Glu Ala Ile Leu Ala 
                245                 250                 255     


Asp Ile Thr Pro Ala Glu Leu Tyr Asp Ala Asp Glu Val Leu Gly Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Val Trp Pro Phe Val Ser Val Asp Gly Asn Ser 
        275                 280                 285             


Ile Ser Asp Gly Val Pro Gly Pro Ile Thr Gln Ser Ile Ile Arg Arg 
    290                 295                 300                 


Tyr Trp Glu Leu Asn Val Glu Pro Ser Ser Leu Leu Thr Pro Val Gln 
305                 310                 315                 320 


Tyr Leu Glu 
            


<210>  3
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Sequence

<400>  3
atggcgacga tggacaaggt gttcgcgggt tacgcggagc gtcaggcggt tctggaagcg       60

agcaagaacc cgctggcgaa aggcgtggcg tggattcagg gcgagctggt tccgctgcac      120

gaagcgcgta ttccgctgct ggaccaaggc ttctacacca gcgatgcgac ctataccacc      180

ttccacgtgt ggaacggcaa cgcgtttcgt ctgggtgatc acatcgagcg tctgtttagc      240

aacgcggaaa gcatccgtct gattccgccg ctgacccaag acgaggtgaa ggaaattgcg      300

ctggagctgg ttgcgaaaac cgagctgcgt gaagcgatgg ttaccgtgac catcacccgt      360

ggttatagca gcaccccgtt cgaacgtgac attaccaagc accgtccgca ggtgtacatg      420

agcgcgtgcc cgtatcaatg gatcgttccg tttgaccgta ttcgtgatgg cgttcacctg      480

atggtggcgc agagcgttcg tcgtaccccg cgtagcagca tcgacccgca ggttaaaaac      540

ttccaatggg gtgatctgat ccgtgcgatt caagaaaccc acgaccgtgg ctttgaactg      600

ccgctgctgc tggactgcga taacctgctg gcggagggtc cgggtttcaa cgtggttgtg      660

atcaaggatg gtgttgttcg ttctccgggt cgtgcggcgc tgccgggcat cacccgtaaa      720

accgtgctgg agattgcgga aagcctgggt cacgaagcga tcctggcgga cattaccccg      780

gcggagctgt acgacgcgga tgaagtgctg ggttgcagca ccggtggcgg tgtttggccg      840

tttgttagcg tggacggcaa cagcatcagc gatggcgttc cgggtccgat tacccagagc      900

atcattcgtc gttactggga gctgaacgtg gaaccgagca gcctgctgac cccggttcaa      960

tatctcgag                                                              969


<210>  4
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Sequence from Nectria haematococca

<400>  4

Met Ala Thr Met Asp Lys Val Phe Ala Gly Tyr Ala Glu Arg Gln Ala 
1               5                   10                  15      


Val Leu Glu Ala Ser Lys Asn Pro Leu Ala Lys Gly Val Ala Trp Ile 
            20                  25                  30          


Gln Gly Glu Leu Val Pro Leu His Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Gln Gly Phe Tyr Thr Ser Asp Ala Thr Tyr Thr Thr Phe His Val Trp 
    50                  55                  60                  


Asn Gly Asn Ala Phe Arg Leu Gly Asp His Ile Glu Arg Leu Phe Ser 
65                  70                  75                  80  


Asn Ala Glu Ser Ile Arg Leu Ile Pro Pro Leu Thr Gln Asp Glu Val 
                85                  90                  95      


Lys Glu Ile Ala Leu Glu Leu Val Ala Lys Thr Glu Leu Arg Glu Ala 
            100                 105                 110         


Met Val Thr Val Thr Ile Thr Arg Gly Tyr Ser Ser Thr Pro Phe Glu 
        115                 120                 125             


Arg Asp Ile Thr Lys His Arg Pro Gln Val Tyr Met Ser Ala Cys Pro 
    130                 135                 140                 


Tyr Gln Trp Ile Val Pro Phe Asp Arg Ile Arg Asp Gly Val His Leu 
145                 150                 155                 160 


Met Val Ala Gln Ser Val Arg Arg Thr Pro Arg Ser Ser Ile Asp Pro 
                165                 170                 175     


Gln Val Lys Asn Phe Gln Trp Gly Asp Leu Ile Arg Ala Ile Gln Glu 
            180                 185                 190         


Thr His Asp Arg Gly Phe Glu Leu Pro Leu Leu Leu Asp Cys Asp Asn 
        195                 200                 205             


Leu Leu Ala Glu Gly Pro Gly Phe Asn Val Val Val Ile Lys Asp Gly 
    210                 215                 220                 


Val Val Arg Ser Pro Gly Arg Ala Ala Leu Pro Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Thr Val Leu Glu Ile Ala Glu Ser Leu Gly His Glu Ala Ile Leu Ala 
                245                 250                 255     


Asp Ile Thr Pro Ala Glu Leu Tyr Asp Ala Asp Glu Val Leu Gly Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Val Trp Pro Phe Val Ser Val Asp Gly Asn Ser 
        275                 280                 285             


Ile Ser Asp Gly Val Pro Gly Pro Ile Thr Gln Ser Ile Ile Arg Arg 
    290                 295                 300                 


Tyr Trp Glu Leu Asn Val Glu Pro Ser Ser Leu Leu Thr Pro Val Gln 
305                 310                 315                 320 


Tyr Leu Glu 
            


<210>  5
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence

<400>  5
atggcgagca tggataaagt gttcgcgggt tatgcggcgc gtcaggcgat cctggagagc       60

accgaaacca ccaacccgtt tgcgaaaggc attgcgtggg tggaaggtga actggttccg      120

ctggcggagg cgcgtatccc gctgctggac caaggcttct acaccagcga tgcgacctat      180

accaccttcc acgtttggaa cggcaacgcg tttcgtctgg gtgatcacat cgagcgtctg      240

tttagcaacg cggaaagcat ccgtctgatt ccgccgctga cccaggacga ggtgaaggaa      300

attgcgctgg agctggttgc gaaaaccgag ctgcgtgaag cgatggttac cgtgaccatc      360

acccgtggtt atagcagcac cccgttcgaa cgtgacatta ccaagcaccg tccgcaggtg      420

tacatgagcg cgtgcccgta tcaatggatc gttccgtttg accgtattcg tgatggcgtt      480

cacctgatgg tggcgcagag cgttcgtcgt accccgcgta gcagcatcga cccgcaggtg      540

aaaaacttcc aatggggtga tctgatccgt gcgattcaag aaacccacga ccgtggcttt      600

gaactgccgc tgctgctgga ctgcgataac ctgctggcgg agggtccggg tttcaacgtg      660

gttgtgatta aggatggtgt tgttcgttct ccgggtcgtg cggcgctgcc gggcatcacc      720

cgtaaaaccg tgctggagat tgcggaaagc ctgggtcacg aagcgatcct ggcggacatt      780

accccggcgg agctgtacga cgcggatgaa gtgctgggtt gcagcaccgg tggcggtgtt      840

tggccgtttg ttagcgtgga cggcaacagc atcagcgatg gcgttccggg tccgattacc      900

cagagcatca ttcgtcgtta ctgggagctg aacgtggaac cgagcagcct gctgaccccg      960

gttcaatatc tcgag                                                       975


<210>  6
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified sequence from Aspergillus terrus

<400>  6

Met Ala Ser Met Asp Lys Val Phe Ala Gly Tyr Ala Ala Arg Gln Ala 
1               5                   10                  15      


Ile Leu Glu Ser Thr Glu Thr Thr Asn Pro Phe Ala Lys Gly Ile Ala 
            20                  25                  30          


Trp Val Glu Gly Glu Leu Val Pro Leu Ala Glu Ala Arg Ile Pro Leu 
        35                  40                  45              


Leu Asp Gln Gly Phe Tyr Thr Ser Asp Ala Thr Tyr Thr Thr Phe His 
    50                  55                  60                  


Val Trp Asn Gly Asn Ala Phe Arg Leu Gly Asp His Ile Glu Arg Leu 
65                  70                  75                  80  


Phe Ser Asn Ala Glu Ser Ile Arg Leu Ile Pro Pro Leu Thr Gln Asp 
                85                  90                  95      


Glu Val Lys Glu Ile Ala Leu Glu Leu Val Ala Lys Thr Glu Leu Arg 
            100                 105                 110         


Glu Ala Met Val Thr Val Thr Ile Thr Arg Gly Tyr Ser Ser Thr Pro 
        115                 120                 125             


Phe Glu Arg Asp Ile Thr Lys His Arg Pro Gln Val Tyr Met Ser Ala 
    130                 135                 140                 


Cys Pro Tyr Gln Trp Ile Val Pro Phe Asp Arg Ile Arg Asp Gly Val 
145                 150                 155                 160 


His Leu Met Val Ala Gln Ser Val Arg Arg Thr Pro Arg Ser Ser Ile 
                165                 170                 175     


Asp Pro Gln Val Lys Asn Phe Gln Trp Gly Asp Leu Ile Arg Ala Ile 
            180                 185                 190         


Gln Glu Thr His Asp Arg Gly Phe Glu Leu Pro Leu Leu Leu Asp Cys 
        195                 200                 205             


Asp Asn Leu Leu Ala Glu Gly Pro Gly Phe Asn Val Val Val Ile Lys 
    210                 215                 220                 


Asp Gly Val Val Arg Ser Pro Gly Arg Ala Ala Leu Pro Gly Ile Thr 
225                 230                 235                 240 


Arg Lys Thr Val Leu Glu Ile Ala Glu Ser Leu Gly His Glu Ala Ile 
                245                 250                 255     


Leu Ala Asp Ile Thr Pro Ala Glu Leu Tyr Asp Ala Asp Glu Val Leu 
            260                 265                 270         


Gly Cys Ser Thr Gly Gly Gly Val Trp Pro Phe Val Ser Val Asp Gly 
        275                 280                 285             


Asn Ser Ile Ser Asp Gly Val Pro Gly Pro Ile Thr Gln Ser Ile Ile 
    290                 295                 300                 


Arg Arg Tyr Trp Glu Leu Asn Val Glu Pro Ser Ser Leu Leu Thr Pro 
305                 310                 315                 320 


Val Gln Tyr Leu Glu 
                325 


<210>  7
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence

<400>  7
atggcgagca tggacaaggt gttcagcggt taccacgcgc gtcagaaact gctggagcgt       60

agcgataacc cgtttagcaa gggcatcgcg tatgtggaag gtaaactggt tctgccgagc      120

gacgcgcgta ttccgctgct ggatgagggc ttctacacca gcgacgcgac ctataccacc      180

ttccacgttt ggaacggcaa cgcgtttcgt ctgggtgacc acatcgagcg tctgtttagc      240

aacgcggaaa gcatccgtct gattccgccg ctgacccaag atgaggtgaa ggaaattgcg      300

ctggagctgg ttgcgaaaac cgagctgcgt gaagcgatgg ttaccgtgac catcacccgt      360

ggttacagca gcaccccgtt cgaacgtgac attaccaagc accgtccgca ggtgtacatg      420

agcgcgtgcc cgtatcaatg gatcgttccg tttgaccgta ttcgtgatgg cgttcacctg      480

atggtggcgc agagcgttcg tcgtaccccg cgtagcagca tcgatccgca ggtgaaaaac      540

ttccaatggg gtgacctgat ccgtgcgatt caagaaaccc acgatcgtgg ctttgaactg      600

ccgctgctgc tggactgcga taacctgctg gcggagggtc cgggtttcaa cgtggttgtg      660

atcaaggatg gtgttgttcg ttctccgggt cgtgcggcgc tgccgggcat cacccgtaaa      720

accgtgctgg agattgcgga aagcctgggt cacgaagcga tcctggcgga tattaccccg      780

gcggagctgt atgacgcgga tgaagtgctg ggttgcagca ccggtggcgg tgtttggccg      840

tttgttagcg tggacggcaa cagcatcagc gatggcgttc cgggtccgat tacccagagc      900

atcattcgtc gttactggga gctgaacgtg gaaccgagca gcctgctgac cccggttcaa      960

tatctcgag                                                              969


<210>  8
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified sequence from Aspergillus fischeri

<400>  8

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr His Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Tyr Thr Ser Asp Ala Thr Tyr Thr Thr Phe His Val Trp 
    50                  55                  60                  


Asn Gly Asn Ala Phe Arg Leu Gly Asp His Ile Glu Arg Leu Phe Ser 
65                  70                  75                  80  


Asn Ala Glu Ser Ile Arg Leu Ile Pro Pro Leu Thr Gln Asp Glu Val 
                85                  90                  95      


Lys Glu Ile Ala Leu Glu Leu Val Ala Lys Thr Glu Leu Arg Glu Ala 
            100                 105                 110         


Met Val Thr Val Thr Ile Thr Arg Gly Tyr Ser Ser Thr Pro Phe Glu 
        115                 120                 125             


Arg Asp Ile Thr Lys His Arg Pro Gln Val Tyr Met Ser Ala Cys Pro 
    130                 135                 140                 


Tyr Gln Trp Ile Val Pro Phe Asp Arg Ile Arg Asp Gly Val His Leu 
145                 150                 155                 160 


Met Val Ala Gln Ser Val Arg Arg Thr Pro Arg Ser Ser Ile Asp Pro 
                165                 170                 175     


Gln Val Lys Asn Phe Gln Trp Gly Asp Leu Ile Arg Ala Ile Gln Glu 
            180                 185                 190         


Thr His Asp Arg Gly Phe Glu Leu Pro Leu Leu Leu Asp Cys Asp Asn 
        195                 200                 205             


Leu Leu Ala Glu Gly Pro Gly Phe Asn Val Val Val Ile Lys Asp Gly 
    210                 215                 220                 


Val Val Arg Ser Pro Gly Arg Ala Ala Leu Pro Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Thr Val Leu Glu Ile Ala Glu Ser Leu Gly His Glu Ala Ile Leu Ala 
                245                 250                 255     


Asp Ile Thr Pro Ala Glu Leu Tyr Asp Ala Asp Glu Val Leu Gly Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Val Trp Pro Phe Val Ser Val Asp Gly Asn Ser 
        275                 280                 285             


Ile Ser Asp Gly Val Pro Gly Pro Ile Thr Gln Ser Ile Ile Arg Arg 
    290                 295                 300                 


Tyr Trp Glu Leu Asn Val Glu Pro Ser Ser Leu Leu Thr Pro Val Gln 
305                 310                 315                 320 


Tyr Leu Glu 
            


<210>  9
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence

<400>  9
atggcgacga tggacgaggt gttcgcgggt tacgcgaagc gtcaggcgac cctggaagcg       60

agcaccaaca tcctgagcca aggcattgcg tgggtggagg gtgaactggt tccgctgcaa      120

agcgcgcgta tcccgctgct ggaccaaggc ttctacacca gcgatgcgac ctataccacc      180

ttccacgttt ggaacggcaa cgcgtttcgt ctgggtgatc acatcgagcg tctgtttagc      240

aacgcggaaa gcatccgtct gattccgccg ctgacccagg acgaggtgaa ggaaattgcg      300

ctggagctgg ttgcgaaaac cgagctgcgt gaagcgatgg ttaccgtgac catcacccgt      360

ggttatagca gcaccccgtt cgaacgtgac attaccaagc accgtccgca ggtgtacatg      420

agcgcgtgcc cgtatcaatg gatcgttccg tttgaccgta ttcgtgatgg cgttcacctg      480

atggtggcgc agagcgttcg tcgtaccccg cgtagcagca tcgacccgca ggtgaaaaac      540

ttccaatggg gtgatctgat ccgtgcgatt caagaaaccc acgaccgtgg ctttgaactg      600

ccgctgctgc tggactgcga taacctgctg gcggagggtc cgggtttcaa cgtggttgtg      660

attaaggatg gtgttgttcg ttctccgggt cgtgcggcgc tgccgggcat cacccgtaaa      720

accgtgctgg agattgcgga aagcctgggt cacgaagcga tcctggcgga cattaccccg      780

gcggagctgt acgacgcgga tgaagtgctg ggttgcagca ccggtggcgg tgtttggccg      840

tttgttagcg tggacggcaa cagcatcagc gatggcgttc cgggtccgat tacccagagc      900

atcattcgtc gttactggga gctgaacgtg gaaccgagca gcctgctgac cccggttcaa      960

tatctcgag                                                              969


<210>  10
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified sequence from Fusarium oxysporum

<400>  10

Met Ala Thr Met Asp Glu Val Phe Ala Gly Tyr Ala Lys Arg Gln Ala 
1               5                   10                  15      


Thr Leu Glu Ala Ser Thr Asn Ile Leu Ser Gln Gly Ile Ala Trp Val 
            20                  25                  30          


Glu Gly Glu Leu Val Pro Leu Gln Ser Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Gln Gly Phe Tyr Thr Ser Asp Ala Thr Tyr Thr Thr Phe His Val Trp 
    50                  55                  60                  


Asn Gly Asn Ala Phe Arg Leu Gly Asp His Ile Glu Arg Leu Phe Ser 
65                  70                  75                  80  


Asn Ala Glu Ser Ile Arg Leu Ile Pro Pro Leu Thr Gln Asp Glu Val 
                85                  90                  95      


Lys Glu Ile Ala Leu Glu Leu Val Ala Lys Thr Glu Leu Arg Glu Ala 
            100                 105                 110         


Met Val Thr Val Thr Ile Thr Arg Gly Tyr Ser Ser Thr Pro Phe Glu 
        115                 120                 125             


Arg Asp Ile Thr Lys His Arg Pro Gln Val Tyr Met Ser Ala Cys Pro 
    130                 135                 140                 


Tyr Gln Trp Ile Val Pro Phe Asp Arg Ile Arg Asp Gly Val His Leu 
145                 150                 155                 160 


Met Val Ala Gln Ser Val Arg Arg Thr Pro Arg Ser Ser Ile Asp Pro 
                165                 170                 175     


Gln Val Lys Asn Phe Gln Trp Gly Asp Leu Ile Arg Ala Ile Gln Glu 
            180                 185                 190         


Thr His Asp Arg Gly Phe Glu Leu Pro Leu Leu Leu Asp Cys Asp Asn 
        195                 200                 205             


Leu Leu Ala Glu Gly Pro Gly Phe Asn Val Val Val Ile Lys Asp Gly 
    210                 215                 220                 


Val Val Arg Ser Pro Gly Arg Ala Ala Leu Pro Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Thr Val Leu Glu Ile Ala Glu Ser Leu Gly His Glu Ala Ile Leu Ala 
                245                 250                 255     


Asp Ile Thr Pro Ala Glu Leu Tyr Asp Ala Asp Glu Val Leu Gly Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Val Trp Pro Phe Val Ser Val Asp Gly Asn Ser 
        275                 280                 285             


Ile Ser Asp Gly Val Pro Gly Pro Ile Thr Gln Ser Ile Ile Arg Arg 
    290                 295                 300                 


Tyr Trp Glu Leu Asn Val Glu Pro Ser Ser Leu Leu Thr Pro Val Gln 
305                 310                 315                 320 


Tyr Leu Glu 
            


