                               SEQUENCE LISTING

<110> JANSSEN PHARMACEUTICA NV
 
<120> THIOETHER CYCLIC PEPTIDE AMYLIN RECEPTOR MODULATORS

<130> PRD3471WOPCT1

<140>
<141>

<150> 62/662,492
<151> 2018-04-25

<160> 66    

<170> PatentIn version 3.5

<210> 1
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MISC_FEATURE
<222> (2)..(7)
<223> Cyclic

<400> 1
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 2
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (2)..(7)
<223> Cyclic

<400> 2
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 3
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (2)..(7)
<223> Cyclic

<400> 3
Lys Cys Asn Thr Ala Thr Cys Val Leu Gly Arg Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Asn Thr Tyr 
            20                  25                  30          


<210> 4
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<400> 4
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 5
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 5
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 6
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<400> 6
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 7
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 7
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 8
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Alloc)

<400> 8
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 9
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 9
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 10
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Alloc)

<400> 10
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 11
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Abu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 11
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 12
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Abu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 12
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 13
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> (S)-Beta-Aib

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 13
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 14
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> (R)-Beta-Aib

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 14
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 15
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-hAla

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 15
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 16
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-hPro

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 16
Asn Thr Pro Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 17
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Pyrrolidinyl-(3S)-carboxyl

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 17
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 18
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> (1R,2R)-2-aminocyclopentanecarboxylic acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 18
Asn Thr Xaa Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 19
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Beta-hThr

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 19
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 20
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Beta-hThr

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 20
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 21
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Beta-hThr

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 21
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 22
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Beta-hThr

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(Ac)

<400> 22
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 23
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(6)
<223> Cyclic

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (6)..(6)
<223> hCys

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys(Ac)

<400> 23
Ser Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 24
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(6)
<223> Cyclic

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys(Ac)

<400> 24
Ser Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 25
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(Ac)

<400> 25
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 26
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Lys(Ac)

<400> 26
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Lys Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 27
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Lys(Ac)

<400> 27
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly Lys 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 28
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<400> 28
Asn Thr Ala Thr Cys Val Leu Gly Arg Leu Ser Gln Glu Leu His Arg 
1               5                   10                  15      


Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Asn Thr Tyr 
            20                  25                  30  


<210> 29
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(OEG2-Pal)

<400> 29
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 30
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(OEG2-gamma-Glu-Pal)

<400> 30
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 31
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Alpha-MeLeu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12-AcBR)

<400> 31
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 32
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> hArg

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12-AcBr)

<400> 32
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 33
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12-AcBr)

<400> 33
Asn Thr Ala Thr Cys Ala Thr Glu Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 34
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Alpha-MeLeu

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12-AcBr)

<400> 34
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 35
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> hArg

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12-AcBr)

<400> 35
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 36
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12-AcBr)

<400> 36
Asn Thr Ala Thr Cys Ala Thr Glu Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 37
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Alpha-MeLeu

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12)

<400> 37
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 38
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> hArg

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12)

<400> 38
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 39
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(dPEG12)

<400> 39
Asn Thr Ala Thr Cys Ala Thr Glu Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 40
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Alpha-MeLeu

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12)

<400> 40
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 41
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> hArg

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12)

<400> 41
Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 42
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Beta-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> hCys

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(dPEG12)

<400> 42
Asn Thr Ala Thr Cys Ala Thr Glu Arg Leu Ala Asn Phe Leu Val His 
1               5                   10                  15      


Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly Ser 
            20                  25                  30          


Asn Thr Tyr 
        35  


<210> 43
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Asp Gly Cys Tyr Gly Glu Leu Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 44
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Asp Gly Cys Tyr Gly Glu Leu Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210> 45
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 46
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 47
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Ser Tyr Ala Met Ser 
1               5   


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Tyr Asp Gly Cys Tyr Gly Glu Leu Asp Phe 
1               5                   10  


<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210> 53
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (7)..(33)
<223> This region may encompass one of the following sequences:
      "VLGRLSQELHRLQTYPRTNTGS" or "ATZ10Z11Z12ANFZ16VHSSNNFGZ25Z26L
      PZ29TNVGZ34" wherein Z10 is Gln or Glu, Z11 is Arg or Lys, 
      Z12 is Leu or (S)-2-amino-2,4-dimethylpentanoic acid, 

<220>
<221> MOD_RES
<222> (7)..(33)
<223> CONT. FROM ABOVE: Z16 is Leu or (S)-2-amino-2,4-
      dimethylpentanoic acid, Z25 is Pro or Lys, Z26 is 
      Ile or Lys, Z29 is Pro or Lys, and Z34 is Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 53
Xaa Asn Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 54
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 54
Ala Thr Xaa Xaa Xaa Ala Asn Phe Xaa Val His Ser Ser Asn Asn Phe 
1               5                   10                  15      


Gly Xaa Xaa Leu Pro Xaa Thr Asn Val Gly Xaa 
            20                  25          


<210> 55
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Val Leu Gly Arg Leu Ser Gln Glu Leu His Arg Leu Gln Thr Tyr Pro 
1               5                   10                  15      


Arg Thr Asn Thr Gly Ser 
            20          


<210> 56
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (7)..(33)
<223> This region may encompass one of the following sequences:
      "VLGRLSQELHRLQTYPRTNTGS" or "ATZ10Z11Z12ANFLVHSSNNFGZ25Z26L
      PZ29TNVGZ34" wherein Z10 is Gln or Glu, Z11 is Arg or Lys, 
      Z12 is Leu or (S)-2-amino-2,4-dimethylpentanoic acid, 

<220>
<221> MOD_RES
<222> (7)..(33)
<223> CONT. FROM ABOVE: Z25 is Pro or Lys, Z26 is 
      Ile or Lys, Z29 is Pro or Lys, and Z34 is Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 56
Xaa Asn Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 57
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MISC_FEATURE
<222> (1)..(6)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (7)..(33)
<223> This region may encompass one of the following sequences:
      "VLGRLSQELHRLQTYPRTNTGS" or "ATZ10Z11Z12ANFLVHSSNNFGZ25Z26L
      PZ29TNVGZ34" wherein Z10 is Gln or Glu, Z11 is Arg or Lys, 
      Z12 is Leu or (S)-2-amino-2,4-dimethylpentanoic acid, 

<220>
<221> MOD_RES
<222> (7)..(33)
<223> CONT. FROM ABOVE: Z25 is Pro or Lys, Z26 is 
      Ile or Lys, Z29 is Pro or Lys, and Z34 is Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 57
Xaa Asn Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 58
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 58
Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe 
1               5                   10                  15      


Gly Xaa Xaa Leu Pro Xaa Thr Asn Val Gly Xaa 
            20                  25          


<210> 59
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Lys(FMOC)

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
Lys Xaa Leu Pro Xaa Thr Asn Val Gly Xaa Asn Thr Tyr 
1               5                   10              


<210> 60
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
Xaa Xaa Leu Pro Xaa Thr Asn Val Gly Xaa Asn Thr Tyr 
1               5                   10              


<210> 61
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
Xaa Asn Xaa Xaa Xaa Cys Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Xaa Xaa Leu Pro Xaa Thr Asn Val Gly 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 62
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(BOC)

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 62
Xaa Asn Xaa Xaa Xaa Cys Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Xaa Leu Pro Xaa Thr Asn Val Gly 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 63
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(NH2)

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 63
Xaa Asn Xaa Xaa Xaa Cys Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Xaa Leu Pro Xaa Thr Asn Val Gly 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 64
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MISC_FEATURE
<222> (1)..(6)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(NH2)

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 64
Xaa Asn Xaa Xaa Xaa Cys Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Xaa Leu Pro Xaa Thr Asn Val Gly 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 65
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser, Gly or not present

<220>
<221> MISC_FEATURE
<222> (1)..(6)
<223> Cyclic

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, beta-Ala, 4-aminobutanoic acid, (S)-3-amino-2-
      methylpropanoic acid, (R)-3-amino-2-methylpropanoic 
      acid, (S)-3-aminobutanoic acid, (S)-2-(pyrrolidin-2-yl)
      acetic acid, (S)-pyrrolidine-3-carboxylic acid, or 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> CONT. FROM ABOVE: (1R,2R)-2-aminocyclopentane-1-carboxylic
      acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or 3-amino-4-hydroxypentanoic acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Cys or hCys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gln or Glu 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or (S)-2-amino-2,4-dimethylpentanoic acid 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(NH-dPEGx-AcBr)

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Lys 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Pro or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser or Lys 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 65
Xaa Asn Xaa Xaa Xaa Cys Ala Thr Xaa Xaa Xaa Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Xaa Leu Pro Xaa Thr Asn Val Gly 
            20                  25                  30          


Xaa Asn Thr Tyr 
        35      


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


