﻿               SEQUENCE LISTING

<110> GIRAUDO Enrico
      
<120> Medical use of combinations of non-natural Semaphorins 3 and antimetabolites

<130> AB1454 PCT S3

<150> EP 18 16 9372.2
<151> 2018-04-25

<160> 85

<170> BiSSAP 1.3.6

<210> 1
<211> 5672
<212> DNA
<213> Homo sapiens


<220> 
<223> wildtype full length SEMA3A (>gi|100913215|ref|NM_006080.2|)

<220> 
<221> CDS
<222> 316..2631
<223> /transl_table=1

<400> 1
aagcaccact gcagcagacc ttgttaattt tttttttttt tctttccaca caacagttgt    60

gcctcattat ccggtgcctg gctcggaatt tttttttttt tttttctttt tggagggttt   120

gaagtttctg tgcttcagtg actgttacag aagaagaggt gttagtgttg ccatgaggtc   180

ttgattgtct gcatttatga atgaaactga cctaaatcac ctgttacctc cagtttccag   240

attgtttgaa cttctctggc cgcacaatac aggaaggaag actaaagcag caaagggacc   300

tacagcgtct gcagc atg ggc tgg tta act agg att gtc tgt ctt ttc tgg    351
                 Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp 
                 1               5                   10          

gga gta tta ctt aca gca aga gca aac tat cag aat ggg aag aac aat     399
Gly Val Leu Leu Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn 
        15                  20                  25              

gtg cca agg ctg aaa tta tcc tac aaa gaa atg ttg gaa tcc aac aat     447
Val Pro Arg Leu Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn 
    30                  35                  40                  

gtg atc act ttc aat ggc ttg gcc aac agc tcc agt tat cat acc ttc     495
Val Ile Thr Phe Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe 
45                  50                  55                  60  

ctt ttg gat gag gaa cgg agt agg ctg tat gtt gga gca aag gat cac     543
Leu Leu Asp Glu Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His 
                65                  70                  75      

ata ttt tca ttc gac ctg gtt aat atc aag gat ttt caa aag att gtg     591
Ile Phe Ser Phe Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val 
            80                  85                  90          

tgg cca gta tct tac acc aga aga gat gaa tgc aag tgg gct gga aaa     639
Trp Pro Val Ser Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys 
        95                  100                 105             

gac atc ctg aaa gaa tgt gct aat ttc atc aag gta ctt aag gca tat     687
Asp Ile Leu Lys Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr 
    110                 115                 120                 

aat cag act cac ttg tac gcc tgt gga acg ggg gct ttt cat cca att     735
Asn Gln Thr His Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile 
125                 130                 135                 140 

tgc acc tac att gaa att gga cat cat cct gag gac aat att ttt aag     783
Cys Thr Tyr Ile Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys 
                145                 150                 155     

ctg gag aac tca cat ttt gaa aac ggc cgt ggg aag agt cca tat gac     831
Leu Glu Asn Ser His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp 
            160                 165                 170         

cct aag ctg ctg aca gca tcc ctt tta ata gat gga gaa tta tac tct     879
Pro Lys Leu Leu Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser 
        175                 180                 185             

gga act gca gct gat ttt atg ggg cga gac ttt gct atc ttc cga act     927
Gly Thr Ala Ala Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr 
    190                 195                 200                 

ctt ggg cac cac cac cca atc agg aca gag cag cat gat tcc agg tgg     975
Leu Gly His His His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp 
205                 210                 215                 220 

ctc aat gat cca aag ttc att agt gcc cac ctc atc tca gag agt gac    1023
Leu Asn Asp Pro Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp 
                225                 230                 235     

aat cct gaa gat gac aaa gta tac ttt ttc ttc cgt gaa aat gca ata    1071
Asn Pro Glu Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile 
            240                 245                 250         

gat gga gaa cac tct gga aaa gct act cac gct aga ata ggt cag ata    1119
Asp Gly Glu His Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile 
        255                 260                 265             

tgc aag aat gac ttt gga ggg cac aga agt ctg gtg aat aaa tgg aca    1167
Cys Lys Asn Asp Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr 
    270                 275                 280                 

aca ttc ctc aaa gct cgt ctg att tgc tca gtg cca ggt cca aat ggc    1215
Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly 
285                 290                 295                 300 

att gac act cat ttt gat gaa ctg cag gat gta ttc cta atg aac ttt    1263
Ile Asp Thr His Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe 
                305                 310                 315     

aaa gat cct aaa aat cca gtt gta tat gga gtg ttt acg act tcc agt    1311
Lys Asp Pro Lys Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser 
            320                 325                 330         

aac att ttc aag gga tca gcc gtg tgt atg tat agc atg agt gat gtg    1359
Asn Ile Phe Lys Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val 
        335                 340                 345             

aga agg gtg ttc ctt ggt cca tat gcc cac agg gat gga ccc aac tat    1407
Arg Arg Val Phe Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr 
    350                 355                 360                 

caa tgg gtg cct tat caa gga aga gtc ccc tat cca cgg cca gga act    1455
Gln Trp Val Pro Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr 
365                 370                 375                 380 

tgt ccc agc aaa aca ttt ggt ggt ttt gac tct aca aag gac ctt cct    1503
Cys Pro Ser Lys Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro 
                385                 390                 395     

gat gat gtt ata acc ttt gca aga agt cat cca gcc atg tac aat cca    1551
Asp Asp Val Ile Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro 
            400                 405                 410         

gtg ttt cct atg aac aat cgc cca ata gtg atc aaa acg gat gta aat    1599
Val Phe Pro Met Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn 
        415                 420                 425             

tat caa ttt aca caa att gtc gta gac cga gtg gat gca gaa gat gga    1647
Tyr Gln Phe Thr Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly 
    430                 435                 440                 

cag tat gat gtt atg ttt atc gga aca gat gtt ggg acc gtt ctt aaa    1695
Gln Tyr Asp Val Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys 
445                 450                 455                 460 

gta gtt tca att cct aag gag act tgg tat gat tta gaa gag gtt ctg    1743
Val Val Ser Ile Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu 
                465                 470                 475     

ctg gaa gaa atg aca gtt ttt cgg gaa ccg act gct att tca gca atg    1791
Leu Glu Glu Met Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met 
            480                 485                 490         

gag ctt tcc act aag cag caa caa cta tat att ggt tca acg gct ggg    1839
Glu Leu Ser Thr Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly 
        495                 500                 505             

gtt gcc cag ctc cct tta cac cgg tgt gat att tac ggg aaa gcg tgt    1887
Val Ala Gln Leu Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys 
    510                 515                 520                 

gct gag tgt tgc ctc gcc cga gac cct tac tgt gct tgg gat ggt tct    1935
Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser 
525                 530                 535                 540 

gca tgt tct cgc tat ttt ccc act gca aag aga cgc aca aga cga caa    1983
Ala Cys Ser Arg Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln 
                545                 550                 555     

gat ata aga aat gga gac cca ctg act cac tgt tca gac tta cac cat    2031
Asp Ile Arg Asn Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His 
            560                 565                 570         

gat aat cac cat ggc cac agc cct gaa gag aga atc atc tat ggt gta    2079
Asp Asn His His Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val 
        575                 580                 585             

gag aat agt agc aca ttt ttg gaa tgc agt ccg aag tcg cag aga gcg    2127
Glu Asn Ser Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala 
    590                 595                 600                 

ctg gtc tat tgg caa ttc cag agg cga aat gaa gag cga aaa gaa gag    2175
Leu Val Tyr Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu 
605                 610                 615                 620 

atc aga gtg gat gat cat atc atc agg aca gat caa ggc ctt ctg cta    2223
Ile Arg Val Asp Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu 
                625                 630                 635     

cgt agt cta caa cag aag gat tca ggc aat tac ctc tgc cat gcg gtg    2271
Arg Ser Leu Gln Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val 
            640                 645                 650         

gaa cat ggg ttc ata caa act ctt ctt aag gta acc ctg gaa gtc att    2319
Glu His Gly Phe Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile 
        655                 660                 665             

gac aca gag cat ttg gaa gaa ctt ctt cat aaa gat gat gat gga gat    2367
Asp Thr Glu His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp 
    670                 675                 680                 

ggc tct aag acc aaa gaa atg tcc aat agc atg aca cct agc cag aag    2415
Gly Ser Lys Thr Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys 
685                 690                 695                 700 

gtc tgg tac aga gac ttc atg cag ctc atc aac cac ccc aat ctc aac    2463
Val Trp Tyr Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn 
                705                 710                 715     

aca atg gat gag ttc tgt gaa caa gtt tgg aaa agg gac cga aaa caa    2511
Thr Met Asp Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln 
            720                 725                 730         

cgt cgg caa agg cca gga cat acc cca ggg aac agt aac aaa tgg aag    2559
Arg Arg Gln Arg Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys 
        735                 740                 745             

cac tta caa gaa aat aag aaa ggt aga aac agg agg acc cac gaa ttt    2607
His Leu Gln Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe 
    750                 755                 760                 

gag agg gca ccc agg agt gtc tga gctgcattac ctctagaaac ctcaaacaag   2661
Glu Arg Ala Pro Arg Ser Val                                      
765                 770                                          

tagaaacttg cctagacaat aactggaaaa acaaatgcaa tatacatgaa cttttttcat  2721

ggcattatgt ggatgtttac aatggtggga aattcagctg agttccacca attataaatt  2781

aaatccatga gtaactttcc taataggctt tttttcctaa taccaccacc taacagagaa  2841

cacaggtgaa tgcagatgtt cactttagca gacttaatgt ttcctatgag atttcactgt  2901

acaggtttgt ctttcttctt tgcctgagaa ataaaaatgt catttgccat attgccatct  2961

aaaggagaaa aactgcatca gcaaagccat tgtattgaac taaaagttta aaatgaactg  3021

catggattta ctaagctgat gaatattcca aaacgtggtt ggattcaagg atatattttg  3081

tctaccggcc ctcatgtttg tatgtacttg aggagtaaaa tgagtaaaat gatactgaat  3141

gaaatgttct gtggaaatat taaaaaaaaa aaaaaacata agccatccat catccagaag  3201

aaaaatggaa tacactgatc tactactgat gtcttctttc agctttgatc taaagatgta  3261

ttttattaaa actataattt aaatgtacca tgaaaaatat gcagtaaaaa ttagttgttt  3321

tctaagctag agtaggattt gtcttacaat tattgtgcta tgtagttttt gttttaaaaa  3381

ttccaatggt gtgctgcttt ctttggacat tttattttca attctataag agggatagat  3441

gacattgttc tagaaacaca tatacatcat taagagtgaa tctctaaaac caggatataa  3501

attatgcttt atttctctga gaaaatcaaa caaatggaag ctgttcacac ctccccttct  3561

ttaagcatta tctaaattaa tttttacttg cataatgttc ttagaaaaaa aaacagaaca  3621

tttaagcagg aaaaaaggaa gaaacaagtt gatttttaag tgcattttac tataatgaat  3681

caatgaaggg aaaaggaact gcatatttca tgaaaataat aagcattgtc ttaatatact  3741

gttaatagaa aatgtgtctt aattccgtgc ttgaatccct gcatgatatt tgagactaag  3801

atctctctta tgattctacc aagaattata tctgtgtcac ttaatttttt taaaagagag  3861

agatcaataa ctattcagag caacatgtta aaggcaaagt ttccaatcat ttacatctgt  3921

atcaggtgcc tcttaccttt ccttatttaa gacaattatt tgtacaagaa acacatgact  3981

cttttcatat caatgggagg gacttttcta caaagtattt tccaggatgc aacccacatt  4041

taaacaatgt aaaattcttt gtttcctgca acaacttaca aaataaggta aaagactaaa  4101

attcaagatt tgcttccttc attgtcctaa gacgattcgt tgagaatcac tgactttgag  4161

atatttaaaa ctttcagcat tatactgtgg tttcttttgc actgcactca cctattcagg  4221

actcctcccc caggttcctc atcatgcaca aaaatgcaaa gaaaacatct tattagtaat  4281

taatgaagca acattgaaat tctaactcta gctgtctttg gattctaatt aactcagcat  4341

caatttctca cctcagacta cagtgaattt ttatttccta tcagctgaaa tatttcacag  4401

atggaagctc atgtttcagt tttaatgact gccttgaata aacaagttgt tgccacttgt  4461

ttcaaacaaa agcctaaaaa taatctacat tcaattttag gctccattga ctaatatggt  4521

gttgcttttg gaagtactgt atatcctcac atggaagcca aattgttaaa ttatttgaag  4581

gacacaccac tgtacagaaa gtagtgtttc aaatataaat cgaagaacaa agagtgctcc  4641

aaaaaatagg tcattctttt attttcataa agtatctaaa ctgtactaac attcagtgtt  4701

gtgtttcatt ctaaatttgc agctgaaata aatttatttg cgatagcaga aatatcttat  4761

tattcatcct cagaaataaa ggatttgaag ggatagagat tatatgataa atttatagaa  4821

gactttcaga atttgaatgc attttgttta gtgttatgaa atgacaatag aaaaaagtct  4881

cgacttcaat taaaagttac acaaacaaac aaatctacag gcatgtcttt atataccatc  4941

aggtctaagt tttcaaagaa aattgtagat ataacttgca gataactcat tacagtcata  5001

atctctgccc atgtgtattg agagggggca gtttgcacga aaaagaatta ttggcccatt  5061

taataattca gctttaaata gactttgtca tatgcatgaa tcatcagaga tgaaactgtt  5121

tgagagactc atgtgacctt acgaaaatta caacagcagt cttaaagtat gaaaaagatg  5181

catcacagca gagacattat ggcccagttg atatcaaatg taaaatgtaa atgcatgtaa  5241

atgcacactt cattttatgt attatttagt aatttgcagt ggtatgtgtt taatattttt  5301

gctacctaca cattaggcaa aaaaaagatg taaataattt gggagaaaaa gaggaagaac  5361

agtgtaaaat aaaactttct ataagtactc catttcaatg tgttcaacat catcctaaaa  5421

ggcaagattt tcccacgcag gtgacaaggt ggtttatgta ctatttaagg gcggaaggtg  5481

cgtgcccgtt caataagcat gttttttgcc aggtaggaaa tatgttccat atctttactt  5541

atcattgcat ttcagatggg aactagaaaa actggagaga aaaatgtaat gaaactgctg  5601

ctgtaaatta ttccttttag catgtattca cttgctaaat acacatttct tcaaaataaa  5661

aaaaaaaaaa a                                                       5672

<210> 2
<211> 771
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:316..2631 from SEQ ID NO 1

<400> 2
Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     
Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 
Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 
Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     
Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         
Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             
Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 
Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 
Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     
Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         
Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             
Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 
Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 
Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     
Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         
Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             
Arg Ser Val 
    770     

<210> 3
<211> 6850
<212> DNA
<213> Mus musculus


<220> 
<223> wildtype full length Sema3A transcript variant 1 (>gi|
      340523098|ref| NM_009152.4|)

<220> 
<221> CDS
<222> 650..2968
<223> /transl_table=1

<400> 3
gtgacaagag ggaaggggag tgggttgagc tcgctcctct cccattgtca gcgcgtctag    60

tgagtgttgg gaaaacctgt ccgcgggatc ctgtgtcatc tctccctgct tgtgcacagg   120

aaaagtccgc gctgctctgc tcacggctgc tcgcaccccc tctctctcct ctctctcttt   180

ctctgtttcc ctttcattct gcttcctcgg agccgaatga agcagggaga gggagcagga   240

ttagagtcag ccaccggcta tcagcggagc ggagataaaa ggaactgctt cttaagcgcc   300

actgccgcag cccttgttaa tttttttctt cttcttcttc ttctttccac acaacagttg   360

tgcctcatta tccggtgcct ggctcgattt ttttctttct tttttctttt tttcttttct   420

ttcttccttt tttttttttt tctttttttg agggtttgaa gtttctgtga ttccgtgact   480

gttacagaag agacgttagt gttgccatga ggtcttgatt gtctgcattt atgaatgaaa   540

ctgacctaaa tcacctgtta cctccagttt ccagattgtt tgaacttctc tggccgcaca   600

atacaggaag gaaggctgcc gcagctcagg gacctccagc gtctgcagc atg ggc tgg   658
                                                      Met Gly Trp 
                                                      1           

ttc act ggg att gcc tgt ctt ttc tgg ggt gta tta ctt aca gcc aga     706
Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu Thr Ala Arg 
    5                   10                  15                  

gca aac tat gca aac gga aag aac aat gtg cca aga ctg aaa tta tcg     754
Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser 
20                  25                  30                  35  

tac aaa gaa atg ttg gaa tcc aac aat gtg atc act ttt aat ggc ttg     802
Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu 
                40                  45                  50      

gcc aac agc tcc agt tac cac acc ttc ctt ctg gat gaa gaa cgg agt     850
Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser 
            55                  60                  65          

aga cta tat gtt gga gca aaa gat cat ata ttt tca ttc aac ttg gtg     898
Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val 
        70                  75                  80              

aac att aaa gat ttt caa aag att gtg tgg cca gta tct tac aca agg     946
Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg 
    85                  90                  95                  

aga gat gaa tgc aaa tgg gct gga aaa gat atc ctg aaa gaa tgt gcc     994
Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala 
100                 105                 110                 115 

aat ttc atc aag gtc ctg gag gct tat aat cag act cac ttg tat gcc    1042
Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His Leu Tyr Ala 
                120                 125                 130     

tgt gga act ggg gct ttc cat cca atc tgc acc tat att gaa gtt gga    1090
Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly 
            135                 140                 145         

cat cat cct gag gac aac att ttt aag ctg cag gac tca cat ttt gaa    1138
His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu 
        150                 155                 160             

aac ggt cgt ggg aag agc cct tat gat ccc aaa cta ctg act gcc tct    1186
Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser 
    165                 170                 175                 

ctt cta ata gac ggt gag ttg tac tct gga act gct gcg gac ttc atg    1234
Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met 
180                 185                 190                 195 

gga cgg gac ttc gct atc ttc aga aca ctg ggg cac cat cac ccc atc    1282
Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile 
                200                 205                 210     

agg acg gag cag cat gac tcc cgg tgg ctc aat gat cct aga ttc atc    1330
Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile 
            215                 220                 225         

agt gcc cat ctc atc cca gag agt gac aac cct gaa gat gac aaa gta    1378
Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val 
        230                 235                 240             

tat ttt ttc ttc cga gaa aat gca ata gac gga gaa cac tct gga aaa    1426
Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys 
    245                 250                 255                 

gcc act cat gct aga ata ggt cag ata tgc aag aat gac ttt ggt gga    1474
Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly 
260                 265                 270                 275 

cac aga agt ctt gtg aat aaa tgg aca aca ttc cta aaa gca cgc ctg    1522
His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
                280                 285                 290     

att tgc tct gtg ccc ggt ccc aat ggc att gac acc cat ttt gat gaa    1570
Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu 
            295                 300                 305         

ttg cag gat gta ttc cta atg aac tct aaa gat cct aaa aat ccg atc    1618
Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile 
        310                 315                 320             

gtc tat gga gtg ttc aca aca tca agc aac atc ttt aag gga tct gct    1666
Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala 
    325                 330                 335                 

gtg tgc atg tac agc atg agt gat gta aga agg gtg ttc ctt ggt cca    1714
Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro 
340                 345                 350                 355 

tat gct cac aga gat ggt ccc aac tat cag tgg gtg cct tac caa gga    1762
Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly 
                360                 365                 370     

aga gtc cct tat cca cgg cca gga act tgt ccc agt aaa aca ttt ggc    1810
Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly 
            375                 380                 385         

gga ttt gac tcc aca aag gac ctt cct gat gat gtc ata act ttt gca    1858
Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala 
        390                 395                 400             

aga agt cat cca gcc atg tac aac cca gtg ttt cct ata aat aat cgc    1906
Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg 
    405                 410                 415                 

ccg atc atg atc aaa aca gat gta aat tat cag ttc aca caa att gtt    1954
Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val 
420                 425                 430                 435 

gta gac cga gtg gat gca gaa gat ggc cag tat gat gtt atg ttc atc    2002
Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile 
                440                 445                 450     

gga aca gat gtt gga acc gtt ctt aaa gtg gtt tca gtc ccc aag gag    2050
Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu 
            455                 460                 465         

act tgg cat gac cta gaa gaa gtt ctt ctg gaa gaa atg acc gtc ttc    2098
Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe 
        470                 475                 480             

cgg gaa cca aca act att tcg gca atg gag ctt tct act aaa cag caa    2146
Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln 
    485                 490                 495                 

cag ctg tac att ggc tca act gcg gga gtg gca cag ctt cct cta cac    2194
Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His 
500                 505                 510                 515 

cgc tgt gac atc tat ggc aaa gcc tgt gca gaa tgc tgc ctc gct cgg    2242
Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg 
                520                 525                 530     

gac cct tac tgt gcc tgg gat ggg tcc tca tgc tca cgc tat ttt cct    2290
Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro 
            535                 540                 545         

act gca aag agg cgc aca aga cga caa gat ata agg aat gga gac cca    2338
Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro 
        550                 555                 560             

ctg act cac tgc tct gac ttg cag cac cat gat aat cat cat ggg ccc    2386
Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His His Gly Pro 
    565                 570                 575                 

agc ctt gaa gag aga atc atc tat gga gtg gaa aac agt agt aca ttc    2434
Ser Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe 
580                 585                 590                 595 

ttg gaa tgc agt ccg aag tca cag aga gcc ttg gta tat tgg caa ttt    2482
Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe 
                600                 605                 610     

cag agg aga aat gaa gat cga aaa gag gag atc aga atg ggt gat cat    2530
Gln Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Met Gly Asp His 
            615                 620                 625         

atc atc agg aca gaa caa ggg ctc ctg ctc cgt agc ctg cag aag aag    2578
Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu Gln Lys Lys 
        630                 635                 640             

gat tca ggc aat tac ctg tgt cac gct gtg gaa cac gga ttc atg caa    2626
Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Met Gln 
    645                 650                 655                 

act ctt ctt aag gta acc ctg gaa gtc att gac aca gaa cat ttg gaa    2674
Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu 
660                 665                 670                 675 

gaa ctt ctt cat aaa gat gac gat gga gat ggc tct aag ata aaa gaa    2722
Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Ile Lys Glu 
                680                 685                 690     

atg tcg agc agc atg acg ccc agc cag aaa gtc tgg tac cga gac ttc    2770
Met Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe 
            695                 700                 705         

atg cag ctc att aac cac ccc aac ctg aac acg atg gat gag ttc tgt    2818
Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys 
        710                 715                 720             

gaa caa gtg tgg aaa agg gac cga aag caa cgc cga caa agg ccg ggg    2866
Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly 
    725                 730                 735                 

cac tct caa ggg agc agc aac aag tgg aag cac atg caa gag agc aag    2914
His Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln Glu Ser Lys 
740                 745                 750                 755 

aaa ggt aga aac agg agg acc cac gag ttt gag cgg gca ccc aga agt    2962
Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser 
                760                 765                 770     

gtc tga gctgcgccac ctcccaaaac ctcaaacaag tacaaacttg cttagataat     3018
Val                                                            
                                                               

aactggaaaa aatgcaatac acatgaacat ttcatggcat tatgtggatg tttacaatga  3078

tgggaagttc aaccgggttc caccaattta agtccgtgag gaactttccc agcaggcttt  3138

cttcagtata ccaacgcttg acagagatca caggtgagca tagatgttca cgtccgctga  3198

cttagtgttt cctctgaaag ttcattttgc ttccttcttt gcctgagaaa taaaaatgtc  3258

atttgccatc gaaaggagaa aaactgcatc agcaaagcca ttttattgaa gcaagagttg  3318

aaaataaact gcatggattt agtaagcaga tgaatattcc aaaacgtgat tggattcaag  3378

gatgttttgt ctaccagcac tcgtgtttgt atgtactgga gaagtaaaat aaggagaatg  3438

acactgagtg aaatagtcta tggagatata aaaacacaaa ccacccatca tccagagtaa  3498

tggagtacat tgatctacta ctgatgtctt ctttcagctt tgatctaaag atgtatttta  3558

ttaaagttat aatttaaatg taccatggca aatatgcagt aaagattagc tgtttcctaa  3618

gctagagtag gtcttgtctt gcagttacca tgctatatcg tttgtttaaa aattccaact  3678

gtgtgctgct tttttacatt gtgttttcag ttctgtaaga ggcagtatat cactttaggt  3738

ccctactcac tgtactatta cttactgaca ccaagaatta tggtcttccc ctttgaagaa  3798

accaaacaga tagaaggtta tcaccctgac ttgcaaaggt attatctaag ttaactctca  3858

catacataat gttttcagtc aaccaaaaat taagacagca caaagagaag aaaacagtca  3918

ttagaggcat cctgaaggat caagagcaaa attaaattca tgtgtctcat gaaaagaaca  3978

ttgtcttaac agagtgttga taaaatgtct ttccctcttg gcttgaatat ttgcatgatg  4038

tgtgaggcat aggactcgct catgattcca catcccacca aagattctat tttcagtcac  4098

ttaatgattt ccaaagcaga gagaaagagc gggggtgggg ggaatcagtg acattcagga  4158

catgttctaa caacaaaatg acacatttct caactatttc tttgtgaatc aactaaattt  4218

tacccaccct gtatgataca attatttgtc tgaacaactt ataagtgttt tatctcaatg  4278

agagtgaaac tatacacttc acctagaaag tgcaaaattc tttgttttat gaataaaata  4338

taagataaca caaaatgttt cagaatgtat agcctttgtt ggttggagat gatttcctaa  4398

gaatcattga gttcaaaatg cttaataaat tcaacattat agaccagttc attggtgcta  4458

caggcctcac ttcaggaatt tttttcttcg atccttcagc atgcacaaaa atgcaaagta  4518

aatatcttct tgctaagaaa tgaagtggcg ttgatatttt aactccagtt gtctcctaat  4578

tctaattaac tcagtattaa cttctcacct caactacacc aaattgtcat tccctcgcca  4638

ctgaaatagt tcacagatgg aagcttctgt ttcagtttta atgattattt aaataaaaaa  4698

acaatttgtt gacatgtctt tcatataaaa gcctaaaatc atcctacatc tgattttagg  4758

ctcattgact aatggtgttg cttttggaaa tatgtcttca aaggcaagct gaatggatga  4818

attatttgag atcacactct gaacagaaaa tattgtcagg aacattaagt gagagaaaga  4878

gggatgctcc aaataagcca ttctctcatt taatagggtc ttaactgtcc aaacatttaa  4938

tgttatattt cattctaaat ttgcatctga tacaagtata ttggcaatta cataactctc  4998

ccatttcttt ctagctctta acaataaagg atctaatgga aggaaggttg tttaataact  5058

ttatggatgc ctttcaaaat cggaatgcat tttgtttagc actaagaaat agcaatagaa  5118

aactgcttag gtttcaatta aaagtgttaa aaacaagcaa atatattaac atgtctcaat  5178

caatcaccat gtctaagttt caaagaaagt tattgattaa ctagggaata aataaataaa  5238

tacacacata catacataaa tcttatgaca gttataacct cccattgtgt attgagagag  5298

gacagtttgc acgaagaaga atgtcccatt tactaagtaa tttagatgga ctttggcata  5358

tgcatgtatc atcacaggta agacctgcct aagagatgca tgtgacctta agcaaattac  5418

cacagcagtc tcacaatagt ctcaagttga aaaagataca tcacagtgga gagagcaggc  5478

cccgctgata gcaactgtaa agtgtaaatg catgcaaatg cacacttatt gcttctttta  5538

tgtataattt agtgatttat aatggtatgt gtttaatatt tttgctacct acacattaga  5598

caaaggtgta aataattttg aaaagagtag aaagagcact gtaaattaca agtttctata  5658

gatgctccat tccagtttgt tcaccatcat cctcaagtgc aagatttccc atacaagtga  5718

tgcggtggct tatgtactac ttaagggcag agagggtgtg cccctcgaag agcatgcttt  5778

ttgccaggtc gtaaattgtt ccgtatctgt atttatcatt gcatttcaga tgggaactag  5838

aaaactggag agaaaaatgt aacgatattg ctgctgtaaa ttattccttt ttagcatgta  5898

ttcagttgct aaatacacat ttcttcaaaa tatttgaatt cagatgtctt tactgttcca  5958

tataacatat ggtattgagg aagataagct tcgaagcctt cgagaaccag agtcaggaat  6018

cagcataatt agctaacaga tttcttcatt gtagtattct gtaaactgtg ttctatattt  6078

atagtgatga tgtgaatttt ttgcccttta aactaaatgc tgttctcttt atgtcatacc  6138

tggaaagaac acatggatga aagtctttaa tcagtggatt atgatgtgaa gcatcataat  6198

tcaagatcaa taccgattcc agatgattgg catctagagg cctgtcctgc agctcatggg  6258

caagcactgc attaatatgg atttatttct gtaatgtgtt caagtccttc tcttataaat  6318

actattttaa acacatattt aattcactga aagtctgtca gagtttattt gcttcaaaga  6378

cacatttgac aaacaggtct tagcactatt atatactaac atgatggtta caaactggcc  6438

tggtgccaaa gaatccaaag cttttaattt taacttggta ataattattt aagtcaatgt  6498

taatatttac agtatatctt tccttaaaga agcaaacatt attttcaaaa gtatggaaat  6558

tctattagct ttattttaaa aactttccta tactagctaa ttcaaaaatc acacatttgt  6618

atattaatag ataaagacaa acccaaagtg aaagttgccc cagaaatggg ttttcttata  6678

actggtcaac tttcttgatt aacctaacca aagaaaaatc ttatttcttc atttccaaca  6738

cccaagtgca caaacacagt ctatggtaga aataaaacca aattaataaa agaggaatga  6798

ttttaagtta tgatattagg acccagacgt gacagcatca acctacaatt cc          6850

<210> 4
<211> 772
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:650..2968 from SEQ ID NO 3

<400> 4
Met Gly Trp Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Val Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     
Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val 
    450                 455                 460                 
Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 
Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His 
                565                 570                 575     
His Gly Pro Ser Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         
Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr 
        595                 600                 605             
Trp Gln Phe Gln Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Met 
    610                 615                 620                 
Gly Asp His Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 
Gln Lys Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly 
                645                 650                 655     
Phe Met Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu 
            660                 665                 670         
His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys 
        675                 680                 685             
Ile Lys Glu Met Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr 
    690                 695                 700                 
Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 
Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     
Arg Pro Gly His Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln 
            740                 745                 750         
Glu Ser Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             
Pro Arg Ser Val 
    770         

<210> 5
<211> 2981
<212> DNA
<213> Homo sapiens


<220> 
<223> wildtype full length SEMA3B, transcript variant 3, (>gi|
      586798179|ref| NM_001290060.1|)

<220> 
<221> CDS
<222> 247..2496
<223> /transl_table=1

<400> 5
gcgtgggtgt gtctgtgatt gtggccaggc ggggcaccct cggaggggag ggttcggaag    60

tggaatgcga ccccccagcc tctttcccct aggggctgta atctgatccc tggggactcc   120

ccccctagcc tcccgccctc gccctcactg ctgactcctc ttccagatcc tggggcagag   180

tccagggcag ctcaaggctc ctccacacac acacccgctg aaccctgagc accctgagct   240

gctgag atg ggg cgg gcc ggg gct gcc gcc gtg atc ccg ggc ctg gcc      288
       Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala 
       1               5                   10                  

ctg ctc tgg gca gtg ggg ctg ggg agt gcc gcc ccc agc ccc cca cgc     336
Leu Leu Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg 
15                  20                  25                  30  

ctt cgg ctc tcc ttc caa gag ctc cag gcc tgg cat ggt ctc cag act     384
Leu Arg Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr 
                35                  40                  45      

ttc agc ctg gag cga acc tgc tgc tac cag gcc ttg ctg gtg gat gag     432
Phe Ser Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu 
            50                  55                  60          

gag cgt gga cgc ctg ttt gtg ggt gcc gag aac cat gtg gcc tcc ctc     480
Glu Arg Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu 
        65                  70                  75              

aac ctg gac aac atc agc aag cgg gcc aag aag ctg gcc tgg ccg gcc     528
Asn Leu Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala 
    80                  85                  90                  

cct gtg gaa tgg cga gag gag tgc aac tgg gca ggg aag gac att ggt     576
Pro Val Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly 
95                  100                 105                 110 

act gag tgc atg aac ttc gtg aag ttg ctg cat gcc tac aac cgc acc     624
Thr Glu Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr 
                115                 120                 125     

cat ttg ctg gcc tgt ggc acg gga gcc ttc cac cca acc tgt gcc ttt     672
His Leu Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe 
            130                 135                 140         

gtg gaa gtg ggc cac cgg gca gag gag ccc gtc ctc cgg ctg gac cca     720
Val Glu Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro 
        145                 150                 155             

gga agg ata gag gat ggc aag ggg aag agt cct tat gac ccc agg cat     768
Gly Arg Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His 
    160                 165                 170                 

cgg gct gcc tcc gtg ctg gtg ggg gag gag cta tac tca ggg gtg gca     816
Arg Ala Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala 
175                 180                 185                 190 

gca gac ctc atg gga cga gac ttt acc atc ttt cgc agc cta ggg caa     864
Ala Asp Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln 
                195                 200                 205     

cgt cca agt ctc cga aca gag cca cac gac tcc cgc tgg ctc aat gag     912
Arg Pro Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu 
            210                 215                 220         

ccc aag ttt gtc aag gta ttt tgg atc ccg gag agc gag aac cca gac     960
Pro Lys Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp 
        225                 230                 235             

gac gac aaa atc tac ttc ttc ttt cgt gag acg gcg gta gag gcg gcg    1008
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala 
    240                 245                 250                 

ccg gca ctg gga cgc ctg tcc gtg tcc cgc gtt ggc cag atc tgc cgg    1056
Pro Ala Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg 
255                 260                 265                 270 

aac gac gtg ggc ggc cag cgc agc ctg gtc aac aag tgg acg acg ttc    1104
Asn Asp Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe 
                275                 280                 285     

ctg aag gcg cgg ctg gtg tgc tcg gtg ccc ggc gtc gag ggc gac acc    1152
Leu Lys Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr 
            290                 295                 300         

cac ttc gat cag ctc cag gat gtg ttt ctg ttg tcc tcg cgg gac cac    1200
His Phe Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His 
        305                 310                 315             

cgg acc ccg ctg ctc tat gcc gtc ttc tcc acg tcc agc agc atc ttc    1248
Arg Thr Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe 
    320                 325                 330                 

cag ggc tct gcg gtg tgc gtg tac agc atg aac gac gtg cgc cgg gcc    1296
Gln Gly Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala 
335                 340                 345                 350 

ttc ttg gga ccc ttt gca cac aag gag ggg ccc atg cac cag tgg gtg    1344
Phe Leu Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val 
                355                 360                 365     

tca tac cag ggt cgc gtc ccc tac ccg cgg cca ggc atg tgc ccc agc    1392
Ser Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser 
            370                 375                 380         

aag acc ttt ggc acc ttc agt tcc acc aag gac ttc cca gac gat gtc    1440
Lys Thr Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val 
        385                 390                 395             

atc cag ttt gcg cgg aac cac ccc ctc atg tac aac tct gtc ctg ccc    1488
Ile Gln Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro 
    400                 405                 410                 

act ggg ggg cgc cct ctt ttc cta caa gtt gga gcc aat tac acc ttc    1536
Thr Gly Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe 
415                 420                 425                 430 

act caa att gcc gcg gac cgg gtt gca gcc gct gac gga cac tat gac    1584
Thr Gln Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp 
                435                 440                 445     

gtc ctc ttc att ggc aca gac gtt ggc acg gtg ctg aag gtg atc tcg    1632
Val Leu Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser 
            450                 455                 460         

gtc ccc aag ggc agt agg ccc agc gca gag ggg ctg ctc ctg gag gag    1680
Val Pro Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu 
        465                 470                 475             

ctg cac gtg ttt gag gac tcg gcc gct gtc acc agc atg caa att tct    1728
Leu His Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser 
    480                 485                 490                 

tcc aag agg cac cag ctg tac gta gcc tcg cgg agc gcg gtg gcc cag    1776
Ser Lys Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln 
495                 500                 505                 510 

atc gcg ttg cac cgc tgc gct gcc cac ggc cgc gtc tgc acc gaa tgc    1824
Ile Ala Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys 
                515                 520                 525     

tgt ctg gcg cgt gac ccc tac tgc gcc tgg gac ggg gtc gcg tgc acg    1872
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr 
            530                 535                 540         

cgc ttc cag ccc agt gcc aag agg cgg ttc cgg cgg caa gac gta agg    1920
Arg Phe Gln Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg 
        545                 550                 555             

aat ggc gac ccc agc acg ttg tgc tcc gga gac tcg tct cgt ccc gcg    1968
Asn Gly Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala 
    560                 565                 570                 

ctg ctg gaa cac aag gtg ttc ggc gtg gag ggc agc agc gcc ttt ctg    2016
Leu Leu Glu His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu 
575                 580                 585                 590 

gag tgt gag ccc cgc tcg ctg cag gcg cgc gtg gag tgg act ttc cag    2064
Glu Cys Glu Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln 
                595                 600                 605     

cgc gca ggg gtg aca gcc cac acc cag gtg ctg gca gag gag cgc acc    2112
Arg Ala Gly Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr 
            610                 615                 620         

gag cgc acc gcc cgg gga cta ctg ctg cgc agg ctg cgg cgc cgg gac    2160
Glu Arg Thr Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp 
        625                 630                 635             

tcg ggc gtg tac ttg tgc gcc gcc gtc gag cag ggc ttt acg caa ccg    2208
Ser Gly Val Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro 
    640                 645                 650                 

ctg cgt cgc ctg tcg ctg cac gtg ttg agt gct acg cag gcc gaa cga    2256
Leu Arg Arg Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg 
655                 660                 665                 670 

ctg gcg cgg gcc gag gag gct gcg ccc gcc gcg ccg ccg ggc ccc aaa    2304
Leu Ala Arg Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys 
                675                 680                 685     

ctc tgg tac cgg gac ttt ctg cag ctg gtg gag ccg ggc gga ggt ggc    2352
Leu Trp Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly 
            690                 695                 700         

agc gcg aac tcc ctg cgc atg tgc cgc ccg cag cct gcg ctg cag tca    2400
Ser Ala Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser 
        705                 710                 715             

ctg ccc ctg gag tcg cgg aga aag ggc cgt aac cgg agg acc cac gcc    2448
Leu Pro Leu Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala 
    720                 725                 730                 

cct gag cct cgc gct gag cgg ggg ccg cgc agc gca acg cac tgg tga    2496
Pro Glu Pro Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp     
735                 740                 745                     

ccagactgtc cccacgccgg gaaccaagca ggagacgaca ggcgagagag gagccagaca  2556

gaccctgaaa agaaggacgg gttggggccg ggcacattgg gggtcaccgg ccgatggaga  2616

caccaaccga caggccctgg ctgagggcag ctgcgcgggc ttatttatta acaggataac  2676

ccttgaatgt agcagccccg ggagggcggc acaggtcggg cgcaggattc agccggaggg  2736

aagggacggg gaagccgagc tccagagcaa cgaccagggc cgaggaggtg cctggagtgc  2796

ccaccctggg agacagaccc cacctccttg ggtagtgagc agtgagcaga aagctgtgaa  2856

caggctgggc tgctggaggt ggggcgaggc aggccgactg tactaaagta acgcaataaa  2916

cgcattatca gccaaagctg gaatggcccc agcagaaaac cccagaaaaa aaaaaaaaaa  2976

aaaaa                                                              2981

<210> 6
<211> 749
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:247..2496 from SEQ ID NO 5

<400> 6
Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 
Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg Asn Gly 
545                 550                 555                 560 
Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala Leu Leu 
                565                 570                 575     
Glu His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu Glu Cys 
            580                 585                 590         
Glu Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln Arg Ala 
        595                 600                 605             
Gly Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr Glu Arg 
    610                 615                 620                 
Thr Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp Ser Gly 
625                 630                 635                 640 
Val Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro Leu Arg 
                645                 650                 655     
Arg Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg Leu Ala 
            660                 665                 670         
Arg Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys Leu Trp 
        675                 680                 685             
Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Ser Ala 
    690                 695                 700                 
Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser Leu Pro 
705                 710                 715                 720 
Leu Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala Pro Glu 
                725                 730                 735     
Pro Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp 
            740                 745                 

<210> 7
<211> 3746
<212> DNA
<213> Mus musculus


<220> 
<223> wildtype full-length Sema3B, transcript variant 1, (>gi|
      615276319|ref| NM_001042779.2|)

<220> 
<221> CDS
<222> 400..2649
<223> /transl_table=1

<400> 7
agtgaaaggc ccaaggctcc tggtggtggc ccctcctgcc acccctccac ctcagctctg    60

acatggccca ctgaagggaa gggcaagagg caaggagggg aggaactgat ctttccaaaa   120

gctcctggga cctgagcttg ctgtggagtg tacagtcatc ccttagctgt ggagggacag   180

caactgcttt gctctttgca cttggtgccc tctggaatga ccacaggatc tgactctcat   240

ctgtcggctc ttcgcccttt actgcctggg gaccttgtcc gcatcatcag tatccttgtc   300

tctgccccag gctggcatga aatcctgggg cagagtccag gactgctgaa ggctcctcca   360

cacacgcctg ctgaaccctg agcgccctga gctgccggc atg ggg cgg gct gag      414
                                           Met Gly Arg Ala Glu 
                                           1               5   

gcc gcc gcc atg atc cca ggc ctg gcc ctt ctc tgg gta gca ggg cta     462
Ala Ala Ala Met Ile Pro Gly Leu Ala Leu Leu Trp Val Ala Gly Leu 
                10                  15                  20      

ggg gat act gcc cct aac ctt ccc cgc ctt cgg ctc tcc ttt caa gaa     510
Gly Asp Thr Ala Pro Asn Leu Pro Arg Leu Arg Leu Ser Phe Gln Glu 
            25                  30                  35          

tta cag gcc cgg cat ggt gtc cga acc ttc agg ctg gag cgg acc tgc     558
Leu Gln Ala Arg His Gly Val Arg Thr Phe Arg Leu Glu Arg Thr Cys 
        40                  45                  50              

tgt tat gaa gcc ttg ctg gtg gat gag gag cgt gga cgc ctg ttt gtg     606
Cys Tyr Glu Ala Leu Leu Val Asp Glu Glu Arg Gly Arg Leu Phe Val 
    55                  60                  65                  

ggt gct gag aac cac gtg gct tcc ctc agc ctg gac aac atc agc aag     654
Gly Ala Glu Asn His Val Ala Ser Leu Ser Leu Asp Asn Ile Ser Lys 
70                  75                  80                  85  

cga gcc aag aag ctg gcc tgg ccc gcc ccc gtg gaa tgg cgt gaa gaa     702
Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val Glu Trp Arg Glu Glu 
                90                  95                  100     

tgc aac tgg gca ggg aag gac att ggt acc gag tgc atg aac ttc gtg     750
Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu Cys Met Asn Phe Val 
            105                 110                 115         

aag ctg ctg cac acc tac aac cac acc cac ttg ctg gcc tgt ggc aca     798
Lys Leu Leu His Thr Tyr Asn His Thr His Leu Leu Ala Cys Gly Thr 
        120                 125                 130             

ggg gct ttc cac cca acc tgt gcc ttt gtg gag gtg ggc cac cgg ctg     846
Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu Val Gly His Arg Leu 
    135                 140                 145                 

gag gaa ccc atg ctt caa ctg gac cgg agg aaa ctt gag gac ggc aag     894
Glu Glu Pro Met Leu Gln Leu Asp Arg Arg Lys Leu Glu Asp Gly Lys 
150                 155                 160                 165 

ggg aag act cct tat gac cca agg cat cgg gct gcc tcg gtg ctg gtg     942
Gly Lys Thr Pro Tyr Asp Pro Arg His Arg Ala Ala Ser Val Leu Val 
                170                 175                 180     

ggg gaa gaa ctg tat tct ggg gtg aca gca gac ctt atg ggc cgg gac     990
Gly Glu Glu Leu Tyr Ser Gly Val Thr Ala Asp Leu Met Gly Arg Asp 
            185                 190                 195         

ttt acc atc ttt cga agc ctt ggt cag aat ccg agt ctc cga aca gag    1038
Phe Thr Ile Phe Arg Ser Leu Gly Gln Asn Pro Ser Leu Arg Thr Glu 
        200                 205                 210             

ccc cat gat tcc cgc tgg ctc aat gaa ccc aag ttt gtc aag gtc ttt    1086
Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys Phe Val Lys Val Phe 
    215                 220                 225                 

tgg atc cca gag agt gag aac cct gat gac gat aaa atc tat ttc ttc    1134
Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp Lys Ile Tyr Phe Phe 
230                 235                 240                 245 

ttc cgc gag tcc gct gtg gaa gca gca cca gca atg ggg cgc atg tct    1182
Phe Arg Glu Ser Ala Val Glu Ala Ala Pro Ala Met Gly Arg Met Ser 
                250                 255                 260     

gtg tct cgt gtt ggc cag atc tgc agg aat gac ctg ggt ggc cag cgg    1230
Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp Leu Gly Gly Gln Arg 
            265                 270                 275         

agc ttg gtc aac aaa tgg acc aca ttt ctg aag gcg cgg ctt gtg tgc    1278
Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val Cys 
        280                 285                 290             

tca gta cct gga gtt gag ggt gac acc cac ttt gac caa ctt cag gat    1326
Ser Val Pro Gly Val Glu Gly Asp Thr His Phe Asp Gln Leu Gln Asp 
    295                 300                 305                 

gtt ttc ctt ctg tcc tcc cga gac cgc cag aca cct ctt ctc tat gct    1374
Val Phe Leu Leu Ser Ser Arg Asp Arg Gln Thr Pro Leu Leu Tyr Ala 
310                 315                 320                 325 

gtc ttc tcc acc tcc agt ggt gtc ttc cag ggc tct gct gtg tgc gtg    1422
Val Phe Ser Thr Ser Ser Gly Val Phe Gln Gly Ser Ala Val Cys Val 
                330                 335                 340     

tac agc atg aac gat gtg cgc cga gcc ttc ttg gga cct ttt gct cac    1470
Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu Gly Pro Phe Ala His 
            345                 350                 355         

aaa gag ggg cct aca cac cag tgg gtg tcc tac cag ggt cgt gtc ccc    1518
Lys Glu Gly Pro Thr His Gln Trp Val Ser Tyr Gln Gly Arg Val Pro 
        360                 365                 370             

tac cca aga cct ggc atg tgc ccc agc aag acc ttt ggc acc ttc agc    1566
Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr Phe Gly Thr Phe Ser 
    375                 380                 385                 

tcc acc aag gac ttc cca gat gac gtt atc cag ttt gct cgg aac cac    1614
Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln Phe Ala Arg Asn His 
390                 395                 400                 405 

cct ctc atg tac aac cca gtc ctg ccc atg ggg ggg cgc cct ctc ttc    1662
Pro Leu Met Tyr Asn Pro Val Leu Pro Met Gly Gly Arg Pro Leu Phe 
                410                 415                 420     

cta caa gtg gga gct ggg tac acc ttc acc caa atc gcc gca gac cga    1710
Leu Gln Val Gly Ala Gly Tyr Thr Phe Thr Gln Ile Ala Ala Asp Arg 
            425                 430                 435         

gta gca gct gcc gat gga cac tac gat gtt ctc ttc att ggt aca gat    1758
Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu Phe Ile Gly Thr Asp 
        440                 445                 450             

gtg ggc aca gtg ctg aaa gtg atc tca gtc ccc aaa ggc agc cga cct    1806
Val Gly Thr Val Leu Lys Val Ile Ser Val Pro Lys Gly Ser Arg Pro 
    455                 460                 465                 

aat tct gaa gga ctt ctc ctg gaa gag ctg cag gtg ttc gag gac tct    1854
Asn Ser Glu Gly Leu Leu Leu Glu Glu Leu Gln Val Phe Glu Asp Ser 
470                 475                 480                 485 

gcc gct atc acc agc atg caa atc tcc tct aaa agg caa caa ctc tac    1902
Ala Ala Ile Thr Ser Met Gln Ile Ser Ser Lys Arg Gln Gln Leu Tyr 
                490                 495                 500     

ata gca tcg cgc agc gca gtg gcc cag att gct ttg cat cgc tgc act    1950
Ile Ala Ser Arg Ser Ala Val Ala Gln Ile Ala Leu His Arg Cys Thr 
            505                 510                 515         

gcc cta ggc cgc gcc tgc gca gaa tgc tgc ttg gcc cgt gat cct tac    1998
Ala Leu Gly Arg Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr 
        520                 525                 530             

tgc gcc tgg gat gga tca gct tgc aca cgc ttc cag cct acg gcc aag    2046
Cys Ala Trp Asp Gly Ser Ala Cys Thr Arg Phe Gln Pro Thr Ala Lys 
    535                 540                 545                 

aga cgg ttc cgg agg caa gac ata agg aat ggc gac ccc agc acc cta    2094
Arg Arg Phe Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Ser Thr Leu 
550                 555                 560                 565 

tgc tct gga gac tct tct cac tct gtg ctg ctg gag aag aag gtg ttg    2142
Cys Ser Gly Asp Ser Ser His Ser Val Leu Leu Glu Lys Lys Val Leu 
                570                 575                 580     

ggt gtg gag agc ggc agc gcg ttt ctg gag tgt gag ccc cgc tcg ctc    2190
Gly Val Glu Ser Gly Ser Ala Phe Leu Glu Cys Glu Pro Arg Ser Leu 
            585                 590                 595         

cag gcg cat gtg cag tgg acc ttc caa ggt gca ggg gag gca gct cac    2238
Gln Ala His Val Gln Trp Thr Phe Gln Gly Ala Gly Glu Ala Ala His 
        600                 605                 610             

acc cag gtg ctg gct gag gag aga gta gag cgc act gcg cgg ggg ctg    2286
Thr Gln Val Leu Ala Glu Glu Arg Val Glu Arg Thr Ala Arg Gly Leu 
    615                 620                 625                 

ctg ttg cgg ggg ctg cgg cgc cag gac tct ggc gtg tat ctt tgc gtc    2334
Leu Leu Arg Gly Leu Arg Arg Gln Asp Ser Gly Val Tyr Leu Cys Val 
630                 635                 640                 645 

gcg gtt gaa caa ggc ttt tca caa cca ctg cgt cgc ctg gtg ctg cat    2382
Ala Val Glu Gln Gly Phe Ser Gln Pro Leu Arg Arg Leu Val Leu His 
                650                 655                 660     

gtg ttg agt gcg gcg cag gct gaa cga ctg gca cgg gca gag gaa gca    2430
Val Leu Ser Ala Ala Gln Ala Glu Arg Leu Ala Arg Ala Glu Glu Ala 
            665                 670                 675         

gcc gct cct gca cct cct ggc cct aaa ctc tgg tac cgg gac ttt ctg    2478
Ala Ala Pro Ala Pro Pro Gly Pro Lys Leu Trp Tyr Arg Asp Phe Leu 
        680                 685                 690             

cag ttg gtg gag cca ggc ggt ggc gga ggt gca aac tcc ctg cga atg    2526
Gln Leu Val Glu Pro Gly Gly Gly Gly Gly Ala Asn Ser Leu Arg Met 
    695                 700                 705                 

tgc cgc ccg cag ccc ggg cac cac tct gtg gca gca gat tca cgt cgt    2574
Cys Arg Pro Gln Pro Gly His His Ser Val Ala Ala Asp Ser Arg Arg 
710                 715                 720                 725 

aag ggt cgc aac aga cgg atg cat gtc tct gag ctc cgt gct gag cgt    2622
Lys Gly Arg Asn Arg Arg Met His Val Ser Glu Leu Arg Ala Glu Arg 
                730                 735                 740     

gga cca cgt agt gca gct cac tgg tga ctcggctgtc cccacaatgg          2669
Gly Pro Arg Ser Ala Ala His Trp                           
            745                                           

gacgaggctg aatatgacac tccaaagagg ggcagacaga tgccaggaag acaaatgagt  2729

tatggctggg ccacactgag gtccttgggc caacagagac acctaaccct tacataggcc  2789

ctggccaaag ggtagcttat ttattaacaa gataacccgt ggatgtagcc tcaaagagtg  2849

gcctaagctc aattcaggat ctaaccagga gggaggggac agagacgtgg ggttccagag  2909

tggaccagga ccagagagtt gtcttgggtg gcagccctgg ggaaagaatt ctctttcttg  2969

ggcagcaagc agcaagctgt gaacagatta gaccgttggg tatggggtga ggcaggccaa  3029

ctgtactaaa gtaacgcaat aaacacatta tcagctgaca ttggaatggc cccagcagac  3089

aacaggtagt cctagacctt gctgggggct cttgggtatc gccctagggg tctcaagacc  3149

tgcattttcc tcatccaaga atgctaaagt gaagattaaa cgtgttagta gacgactacg  3209

ctggttccag tgagcctctg gggtactggc aatacacagt gcattagtgg caggaccaag  3269

ctctctgaag taaaaccaat actggctgtt gtgggcaagg atgtattaat tcactgaacg  3329

ggtggtgttt gagctgaata agaaggagcc aatcaccaat gtctggtgac agaacattcc  3389

gggatagaag aaccagggca acaacgtcgt ggagcagggg acagaccctc caagtctgcg  3449

gaacaaccag gaggctgata tggtgttatg gcactatgga ctcctgatgg tttggaaggt  3509

agatcccacc agccctgctt ttcaccgttg agaaacagaa cagagtccac ccagactaag  3569

gcctgcaagc tggaccagca cccttcaaga gagccacgtg cctctctctc cgtggcctgt  3629

caagcccttg tgaagaggag agggaggacc caaaacctct taagtgcttt agccatgctt  3689

cttcattttt attctcagta cagttggcca ggaacctttg ttcctgtttt acagatg     3746

<210> 8
<211> 749
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:400..2649 from SEQ ID NO 7

<400> 8
Met Gly Arg Ala Glu Ala Ala Ala Met Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Val Ala Gly Leu Gly Asp Thr Ala Pro Asn Leu Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Arg His Gly Val Arg Thr Phe Arg 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Glu Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Ser Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Thr Tyr Asn His Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Leu Glu Glu Pro Met Leu Gln Leu Asp Arg Arg Lys 
145                 150                 155                 160 
Leu Glu Asp Gly Lys Gly Lys Thr Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Thr Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Asn Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Met Gly Arg Met Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Leu Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp Arg Gln Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Gly Val Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Thr His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Pro Val Leu Pro Met Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Gly Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Asn Ser Glu Gly Leu Leu Leu Glu Glu Leu Gln 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Ile Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg Gln Gln Leu Tyr Ile Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Thr Ala Leu Gly Arg Ala Cys Ala Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Thr Ala Lys Arg Arg Phe Arg Arg Gln Asp Ile Arg Asn Gly 
545                 550                 555                 560 
Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser His Ser Val Leu Leu 
                565                 570                 575     
Glu Lys Lys Val Leu Gly Val Glu Ser Gly Ser Ala Phe Leu Glu Cys 
            580                 585                 590         
Glu Pro Arg Ser Leu Gln Ala His Val Gln Trp Thr Phe Gln Gly Ala 
        595                 600                 605             
Gly Glu Ala Ala His Thr Gln Val Leu Ala Glu Glu Arg Val Glu Arg 
    610                 615                 620                 
Thr Ala Arg Gly Leu Leu Leu Arg Gly Leu Arg Arg Gln Asp Ser Gly 
625                 630                 635                 640 
Val Tyr Leu Cys Val Ala Val Glu Gln Gly Phe Ser Gln Pro Leu Arg 
                645                 650                 655     
Arg Leu Val Leu His Val Leu Ser Ala Ala Gln Ala Glu Arg Leu Ala 
            660                 665                 670         
Arg Ala Glu Glu Ala Ala Ala Pro Ala Pro Pro Gly Pro Lys Leu Trp 
        675                 680                 685             
Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Gly Ala 
    690                 695                 700                 
Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Gly His His Ser Val Ala 
705                 710                 715                 720 
Ala Asp Ser Arg Arg Lys Gly Arg Asn Arg Arg Met His Val Ser Glu 
                725                 730                 735     
Leu Arg Ala Glu Arg Gly Pro Arg Ser Ala Ala His Trp 
            740                 745                 

<210> 9
<211> 5189
<212> DNA
<213> Homo sapiens


<220> 
<223> wildtype full-length SEMA3C (>gi| 335057525|ref| NM_006379.3|)

<220> 
<221> CDS
<222> 563..2818
<223> /transl_table=1

<400> 9
ggactgcgaa aggagcaggg ttgcggagct agggctccag cctgcggccg cgcattcttg    60

cgtctggcca gccgcgagct ctaagggtcg gccccgcccg gtccgccccc gcggctccct   120

gccaggctct cgcgggcgcg ctcggggtgg ggcctcgcgg ctggcggaga tgcggccggg   180

gctgcgcggt ggtgatgcga gcctgctggg cggcgcgccg gggcagccgg agccgcgcgc   240

cgcggcgctg taatcggaca ccaagagcgc tcgcccccgg cctccggcca ctttccattc   300

actccgaggt gcttgattga gcgacgcgga gaagagctcc gggtgccgcg gcactgcagc   360

gctgagattc ctttacaaag aaactcagag gaccgggaag aaagaatttc acctttgcga   420

cgtgctagaa aataaggtcg tctgggaaaa ggactggaga cacaagcgca tccaaccccg   480

gtagcaaact gatgactttt ccgtgctgat ttctttcaac ctcggtattt tcccttggat   540

attaacttgc atatctgaag aa atg gca ttc cgg aca att tgc gtg ttg gtt    592
                         Met Ala Phe Arg Thr Ile Cys Val Leu Val 
                         1               5                   10  

gga gta ttt att tgt tct atc tgt gtg aaa gga tct tcc cag ccc caa     640
Gly Val Phe Ile Cys Ser Ile Cys Val Lys Gly Ser Ser Gln Pro Gln 
                15                  20                  25      

gca aga gtt tat tta aca ttt gat gaa ctt cga gaa acc aag acc tct     688
Ala Arg Val Tyr Leu Thr Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser 
            30                  35                  40          

gaa tac ttc agc ctt tcc cac cat cct tta gac tac agg att tta tta     736
Glu Tyr Phe Ser Leu Ser His His Pro Leu Asp Tyr Arg Ile Leu Leu 
        45                  50                  55              

atg gat gaa gat cag gac cgg ata tat gtg gga agc aaa gat cac att     784
Met Asp Glu Asp Gln Asp Arg Ile Tyr Val Gly Ser Lys Asp His Ile 
    60                  65                  70                  

ctt tcc ctg aat att aac aat ata agt caa gaa gct ttg agt gtt ttc     832
Leu Ser Leu Asn Ile Asn Asn Ile Ser Gln Glu Ala Leu Ser Val Phe 
75                  80                  85                  90  

tgg cca gca tct aca atc aaa gtt gaa gaa tgc aaa atg gct ggc aaa     880
Trp Pro Ala Ser Thr Ile Lys Val Glu Glu Cys Lys Met Ala Gly Lys 
                95                  100                 105     

gat ccc aca cac ggc tgt ggg aac ttt gtc cgt gta att cag act ttc     928
Asp Pro Thr His Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe 
            110                 115                 120         

aat cgc aca cat ttg tat gtc tgt ggg agt ggc gct ttc agt cct gtc     976
Asn Arg Thr His Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val 
        125                 130                 135             

tgt act tac ttg aac aga ggg agg aga tca gag gac caa gtt ttc atg    1024
Cys Thr Tyr Leu Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met 
    140                 145                 150                 

att gac tcc aag tgt gaa tct gga aaa gga cgc tgc tct ttc aac ccc    1072
Ile Asp Ser Lys Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro 
155                 160                 165                 170 

aac gtg aac acg gtg tct gtt atg atc aat gag gag ctt ttc tct gga    1120
Asn Val Asn Thr Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly 
                175                 180                 185     

atg tat ata gat ttc atg ggg aca gat gct gct att ttt cga agt tta    1168
Met Tyr Ile Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu 
            190                 195                 200         

acc aag agg aat gcg gtc aga act gat caa cat aat tcc aaa tgg cta    1216
Thr Lys Arg Asn Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu 
        205                 210                 215             

agt gaa cct atg ttt gta gat gca cat gtc atc cca gat ggt act gat    1264
Ser Glu Pro Met Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp 
    220                 225                 230                 

cca aat gat gct aag gtg tac ttc ttc ttc aaa gaa aaa ctg act gac    1312
Pro Asn Asp Ala Lys Val Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp 
235                 240                 245                 250 

aat aac agg agc acg aaa cag att cat tcc atg att gct cga ata tgt    1360
Asn Asn Arg Ser Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys 
                255                 260                 265     

cct aat gac act ggt gga ctg cgt agc ctt gtc aac aag tgg acc act    1408
Pro Asn Asp Thr Gly Gly Leu Arg Ser Leu Val Asn Lys Trp Thr Thr 
            270                 275                 280         

ttc tta aag gcg agg ctg gtg tgc tcg gta aca gat gaa gac ggc cca    1456
Phe Leu Lys Ala Arg Leu Val Cys Ser Val Thr Asp Glu Asp Gly Pro 
        285                 290                 295             

gaa aca cac ttt gat gaa tta gag gat gtg ttt ctg ctg gaa act gat    1504
Glu Thr His Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Glu Thr Asp 
    300                 305                 310                 

aac ccg agg aca aca cta gtg tat ggc att ttt aca aca tca agc tca    1552
Asn Pro Arg Thr Thr Leu Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser 
315                 320                 325                 330 

gtt ttc aaa gga tca gcc gtg tgt gtg tat cat tta tct gat ata cag    1600
Val Phe Lys Gly Ser Ala Val Cys Val Tyr His Leu Ser Asp Ile Gln 
                335                 340                 345     

act gtg ttt aat ggg cct ttt gcc cac aaa gaa ggg ccc aat cat cag    1648
Thr Val Phe Asn Gly Pro Phe Ala His Lys Glu Gly Pro Asn His Gln 
            350                 355                 360         

ctg att tcc tat cag ggc aga att cca tat cct cgc cct gga act tgt    1696
Leu Ile Ser Tyr Gln Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys 
        365                 370                 375             

cca gga gga gca ttt aca ccc aat atg cga acc acc aag gag ttc cca    1744
Pro Gly Gly Ala Phe Thr Pro Asn Met Arg Thr Thr Lys Glu Phe Pro 
    380                 385                 390                 

gat gat gtt gtc act ttt att cgg aac cat cct ctc atg tac aat tcc    1792
Asp Asp Val Val Thr Phe Ile Arg Asn His Pro Leu Met Tyr Asn Ser 
395                 400                 405                 410 

atc tac cca atc cac aaa agg cct ttg att gtt cgt att ggc act gac    1840
Ile Tyr Pro Ile His Lys Arg Pro Leu Ile Val Arg Ile Gly Thr Asp 
                415                 420                 425     

tac aag tat aca aag ata gct gtg gat cga gtg aac gct gct gat ggg    1888
Tyr Lys Tyr Thr Lys Ile Ala Val Asp Arg Val Asn Ala Ala Asp Gly 
            430                 435                 440         

aga tac cat gtc ctg ttt ctc gga aca gat cgg ggt act gtg caa aaa    1936
Arg Tyr His Val Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys 
        445                 450                 455             

gtg gtt gtt ctt cct act aac aac tct gtc agt ggc gag ctc att ctg    1984
Val Val Val Leu Pro Thr Asn Asn Ser Val Ser Gly Glu Leu Ile Leu 
    460                 465                 470                 

gag gag ctg gaa gtc ttt aag aat cat gct cct ata aca aca atg aaa    2032
Glu Glu Leu Glu Val Phe Lys Asn His Ala Pro Ile Thr Thr Met Lys 
475                 480                 485                 490 

att tca tct aaa aag caa cag ttg tat gtg agt tcc aat gaa ggg gtt    2080
Ile Ser Ser Lys Lys Gln Gln Leu Tyr Val Ser Ser Asn Glu Gly Val 
                495                 500                 505     

tcc cag gta tct ctg cac cgc tgc cac atc tat ggt aca gcc tgt gct    2128
Ser Gln Val Ser Leu His Arg Cys His Ile Tyr Gly Thr Ala Cys Ala 
            510                 515                 520         

gac tgc tgc ctg gcg cgg gac cct tat tgc gcc tgg gat ggc cat tcc    2176
Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly His Ser 
        525                 530                 535             

tgt tcc aga ttc tac cca act ggg aaa cgg agg agc cga aga caa gat    2224
Cys Ser Arg Phe Tyr Pro Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp 
    540                 545                 550                 

gtg aga cat gga aac cca ctg act caa tgc aga gga ttt aat cta aaa    2272
Val Arg His Gly Asn Pro Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys 
555                 560                 565                 570 

gca tac aga aat gca gct gaa att gtc cag tat gga gta aaa aat aac    2320
Ala Tyr Arg Asn Ala Ala Glu Ile Val Gln Tyr Gly Val Lys Asn Asn 
                575                 580                 585     

acc act ttt ctg gag tgt gcc ccc aag tct ccg cag gca tct atc aag    2368
Thr Thr Phe Leu Glu Cys Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys 
            590                 595                 600         

tgg ctg tta cag aaa gac aaa gac agg agg aaa gag gtt aag ctg aat    2416
Trp Leu Leu Gln Lys Asp Lys Asp Arg Arg Lys Glu Val Lys Leu Asn 
        605                 610                 615             

gaa cga ata ata gcc act tca cag gga ctc ctg atc cgc tct gtt cag    2464
Glu Arg Ile Ile Ala Thr Ser Gln Gly Leu Leu Ile Arg Ser Val Gln 
    620                 625                 630                 

ggt tct gac caa gga ctt tat cac tgc att gct aca gaa aat agt ttc    2512
Gly Ser Asp Gln Gly Leu Tyr His Cys Ile Ala Thr Glu Asn Ser Phe 
635                 640                 645                 650 

aag cag acc ata gcc aag atc aac ttc aaa gtt tta gat tca gaa atg    2560
Lys Gln Thr Ile Ala Lys Ile Asn Phe Lys Val Leu Asp Ser Glu Met 
                655                 660                 665     

gtg gct gtt gtg acg gac aaa tgg tcc cca tgg acc tgg gcc agc tct    2608
Val Ala Val Val Thr Asp Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser 
            670                 675                 680         

gtg agg gct tta ccc ttc cac ccg aag gac atc atg ggg gca ttc agc    2656
Val Arg Ala Leu Pro Phe His Pro Lys Asp Ile Met Gly Ala Phe Ser 
        685                 690                 695             

cac tca gaa atg cag atg att aac caa tat tgc aaa gac act cgg cag    2704
His Ser Glu Met Gln Met Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln 
    700                 705                 710                 

caa cat cag cag gga gat gaa tca cag aaa atg aga ggg gac tat ggc    2752
Gln His Gln Gln Gly Asp Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly 
715                 720                 725                 730 

aag tta aag gcc ctc atc aat agt cgg aaa agt aga aac agg agg aat    2800
Lys Leu Lys Ala Leu Ile Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn 
                735                 740                 745     

cag ttg cca gag tca taa tattttctta tgtgggtctt atgcttccat           2848
Gln Leu Pro Glu Ser                                      
            750                                          

taacaaatgc tctgtcttca atgatcaaat tttgagcaaa gaaacttgtg ctttaccaag  2908

gggaattact gaaaaaggtg attactcctg aagtgagttt tacacgaact gaaatgagca  2968

tgcattttct tgtatgatag tgactagcac tagacatgtc atggtcctca tggtgcatat  3028

aaatatattt aacttaaccc agattttatt tatatcttta ttcacctttt cttcaaaatc  3088

gatatggtgg ctgcaaaact agaattgttg catccctcaa ttgaatgagg gccatatccc  3148

tgtggtattc ctttcctgct ttggggcttt agaattctaa ttgtcagtga ttttgtatat  3208

gaaaacaagt tccaaatcca cagcttttac gtagtaaaag tcataaatgc atatgacaga  3268

atggctatca aaagaaatag aaaaggaaga cagcatttaa agttgtataa aaacatgagt  3328

tattcataaa gagaaaatga tgagttttta tggttccaat gaaatatgtt ggggtttttt  3388

taagattgta aaaataatca gttactggta tctgtcactg acctttgttt ccttattcag  3448

gaagataaaa atcagtaacc taccccatga agatatttgg tgggagttat atcagtgaag  3508

cagtttggtt tatattctta tgttatcacc ttccaaacaa aagcacttac tttttttgga  3568

agttatttat tttagactca aagaatataa tctggcacta ctcagttatt actgtttgtt  3628

ctcttattcc ctagtctgtg tggcaaatta aacaatataa gaaggaaaaa tttgaagtat  3688

tagacttcta aataaggtgt gaaatcatca aaaagaaaaa tcaaagtaga aactactaat  3748

tttttaagag gaatttataa caaatatggc tagttttcaa cttcagtact caaattcaat  3808

gattcttcct tttattaaaa ccagtctcag atatcatact gatttttaag tcaacactat  3868

atattttatg atcttttcag tgtgatggca aggtgcttgt tatgtctaga aagtaagaaa  3928

acaatatgag gagacattct gtctttcaaa aggtaatggt acatacgttc actggtctct  3988

aagtgtaaaa gtagtaaatt ttgtgatgaa taaaataatt atctcctaat tgtatgttag  4048

aataatttta ttagaataat ttcatactga aattattttc tccaaataaa aattagatgg  4108

aaaaatgtga aaaaaattat tcatgctctc atatatattt taaaaacact acttttgctt  4168

ttttatttac cttttaagac attttcatgc ttccaggtaa aaacagatat tgtaccatgt  4228

acctaatcca aatatcatat aaacatttta tttatagtta ataatctatg atgaaggtaa  4288

ttaaagtaga ttatggcctt tttaagtatt gcagtctaaa acttcaaaaa ctaaaatcat  4348

tgtcaaaatt aatatgatta ttaatcagaa tatcagaata tgattcacta tttaaactat  4408

gataaattat gataatatat gaggaggcct cgctatagca aaaatagtta aaatgctgac  4468

ataacaccaa acttcatttt ttaaaaaatc tgttgttcca aatgtgtata attttaaagt  4528

aatttctaaa gcagtttatt ataatggttt gcctgcttaa aaggtataat taaacttctt  4588

ttctcttcta cattgacaca cagaaatgtg tcaatgtaaa gccaaaacca tcttctgtgt  4648

ttatggccaa tctattctca aagttaaaag taaaattgtt tcagagtcac agttcccttt  4708

atttcacata agcccaaact gatagacagt aacggtgttt agttttatac tatatttgtg  4768

ctatttaatt ctttctattt tcacaattat taaattgtgt acactttcat tacttttaaa  4828

aatgtagaaa ttcttcatga acataactct gctgaatgta aaagaaaatt ttttttcaaa  4888

aatgctgtta atgtatacta ctggtggttg attggtttta ttttatgtag cttgacaatt  4948

cagtgactta atatctattc catttgtatt gtacataaaa ttttctagaa atacactttt  5008

ttccaaagtg taagtttgtg aatagatttt agcatgatga aactgtcata atggtgaatg  5068

ttcaatctgt gtaagaaaac aaactaaatg tagttgtcac actaaaattt aattggatat  5128

tgatgaaatc attggcctgg caaaataaaa catgttgaat tccccaaaaa aaaaaaaaaa  5188

a                                                                  5189

<210> 10
<211> 751
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:563..2818 from SEQ ID NO 9

<400> 10
Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      
Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          
Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              
His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  
Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  
Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      
Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         
Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             
Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 
Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 
Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     
Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         
Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             
Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 
Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 
Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     
Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         
Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             
Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 
Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 
Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     
Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         
Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             
Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 
Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 
Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     
Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         
Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             
Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 
Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 
Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     
Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         
Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             
Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 
Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 
Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     
Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         
Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             
Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 
Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 
Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     
Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         
Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             
His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 
Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 
Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     
Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     

<210> 11
<211> 4956
<212> DNA
<213> Mus musculus


<220> 
<223> wildtype full-length Sema3C (>gi| 118130842|ref| NM_013657.5|)

<220> 
<221> CDS
<222> 189..2444
<223> /transl_table=1

<400> 11
ctgctacaaa gaaactcagc accggccggc aggaatccca ccctccggac tcactaagtc    60

tttaaaggtc ttctggggaa aggacctagg ggactggaaa tccaagcccg gagcaagtgg   120

ctgacttctc ctggatcttt tcccacctcg gtattttccc ttggatatta attcccaaat   180

cagaagaa atg gca ttc cgg gcg att tgt gtg ttg gtt gga gta ttt att    230
         Met Ala Phe Arg Ala Ile Cys Val Leu Val Gly Val Phe Ile 
         1               5                   10                  

tgt tcc att tgt gta cga gga tct tcc cag ccc caa gca aga gtt tat     278
Cys Ser Ile Cys Val Arg Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr 
15                  20                  25                  30  

tta aca ttt gat gag ctt cga gaa acc aaa acc tct gag tac ttt agt     326
Leu Thr Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser 
                35                  40                  45      

ctg tcc cac cag cag tta gac tac aga ata ttg ctg atg gat gaa gat     374
Leu Ser His Gln Gln Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp 
            50                  55                  60          

caa gac cgg ata tat gtg ggg agc aaa gac cac atc ctg tct ttg aat     422
Gln Asp Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn 
        65                  70                  75              

atc aac aat atc agt caa gaa cct ttg agt gtt ttc tgg cca gca tca     470
Ile Asn Asn Ile Ser Gln Glu Pro Leu Ser Val Phe Trp Pro Ala Ser 
    80                  85                  90                  

aca atc aaa gtt gaa gag tgc aaa atg gct ggc aaa gat cct aca cat     518
Thr Ile Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His 
95                  100                 105                 110 

ggc tgt gga aat ttc gtc cgg gtg att cag aca ttc aac cgt act cac     566
Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His 
                115                 120                 125     

ctg tat gtc tgt ggg agt gga gcg ttc agc cca gtg tgc acc tac ctg     614
Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu 
            130                 135                 140         

aac cgg gga agg agg tca gag gac cag gta ttc atg atc gac tct aag     662
Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys 
        145                 150                 155             

tgt gaa tct ggc aaa gga cga tgc tct ttc aac ccg aat gtg aac act     710
Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr 
    160                 165                 170                 

gtg tct gtt atg atc aat gag gaa ctc ttc tca gga atg tat ata gac     758
Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp 
175                 180                 185                 190 

ttc atg gga aca gat gct gct att ttc cga agt tta act aag agg aat     806
Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn 
                195                 200                 205     

gca gtt cga act gat caa cat aat tca aaa tgg ctg agt gaa ccc atg     854
Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met 
            210                 215                 220         

ttt gtg gac gca cat gtg atc cca gat ggc act gat cca aat gat gct     902
Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala 
        225                 230                 235             

aag gtc tat ttc ttc ttc aaa gaa aga ctg act gac aac aat agg agc     950
Lys Val Tyr Phe Phe Phe Lys Glu Arg Leu Thr Asp Asn Asn Arg Ser 
    240                 245                 250                 

aca aaa cag att cat tcc atg att gca aga ata tgc cct aat gac act     998
Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr 
255                 260                 265                 270 

ggt gga caa cgt agt ctt gtc aac aag tgg acc aca ttc tta aag gca    1046
Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala 
                275                 280                 285     

aga ctt gta tgc tca gtc aca gat gaa gat ggc cca gag aca cat ttt    1094
Arg Leu Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe 
            290                 295                 300         

gat gaa cta gag gat gtc ttt ctg ctg gaa act gac aat cca agg aca    1142
Asp Glu Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr 
        305                 310                 315             

aca ctc gtg tat ggc atc ttc acc aca tca agc tct gtt ttt aag gga    1190
Thr Leu Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly 
    320                 325                 330                 

tcg gca gtg tgt gtg tat cat tta tct gat ata cag act gta ttc aat    1238
Ser Ala Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn 
335                 340                 345                 350 

ggg ccc ttt gcc cac aag gaa ggg ccc aat cac cag ctg atc tcc tat    1286
Gly Pro Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr 
                355                 360                 365     

caa ggt aga atc cca tat cct cgc cca gga act tgc cca gga ggg gcc    1334
Gln Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala 
            370                 375                 380         

ttt aca ccc aat atg aga acc acc aag gac ttc cca gat gac gtt gtc    1382
Phe Thr Pro Asn Met Arg Thr Thr Lys Asp Phe Pro Asp Asp Val Val 
        385                 390                 395             

act ttt att cgg aac cac cct ctc atg tac aat tcc atc tac ccc atc    1430
Thr Phe Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile 
    400                 405                 410                 

cac aga agg cct ctg ata gtc cgc ata ggc act gac tac aag tac aca    1478
His Arg Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr 
415                 420                 425                 430 

aag att gct gtg gac cgt gtc aac gct gct gat ggg aga tac cac gtt    1526
Lys Ile Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val 
                435                 440                 445     

ctg ttt ctg ggc aca gat cgg ggc acc gtg cag aag gtc gta gtc ctt    1574
Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu 
            450                 455                 460         

cct acc aat agc tct gcc agt ggg gaa ctc atc ctg gag gag ctg gaa    1622
Pro Thr Asn Ser Ser Ala Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu 
        465                 470                 475             

gtc ttc aag aat cat gtt ccc ata aca aca atg aaa atc tca tcc aaa    1670
Val Phe Lys Asn His Val Pro Ile Thr Thr Met Lys Ile Ser Ser Lys 
    480                 485                 490                 

aag caa cag ttg tac gtg agc tcc aat gag ggg gtt tcc caa gtc tct    1718
Lys Gln Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser 
495                 500                 505                 510 

ctg cat cgc tgc cat atc tac ggc aca gcc tgt gcg gac tgc tgc ttg    1766
Leu His Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu 
                515                 520                 525     

gcg agg gat cca tac tgt gcc tgg gat ggc cac tct tgc tct agg ttc    1814
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe 
            530                 535                 540         

tac ccc act ggg aag cgg agg agc cga aga caa gat gtg aga cat gga    1862
Tyr Pro Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly 
        545                 550                 555             

aac cca ctg aca caa tgc cga ggg ttc aat ctg aaa gca tac aga aat    1910
Asn Pro Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn 
    560                 565                 570                 

gca gct gaa att gtt cag tat gga gta aga aat aac agc act ttc ctt    1958
Ala Ala Glu Ile Val Gln Tyr Gly Val Arg Asn Asn Ser Thr Phe Leu 
575                 580                 585                 590 

gag tgt gct ccc aag tct cca cag gca tct atc aag tgg ttg ctg cag    2006
Glu Cys Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln 
                595                 600                 605     

aaa gac aaa gac agg agg aag gag gtt aaa ctg aac gag cgc att ata    2054
Lys Asp Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile 
            610                 615                 620         

gct act tcc caa gga cta ctg att cgc tct gtt caa gat tct gac caa    2102
Ala Thr Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Asp Ser Asp Gln 
        625                 630                 635             

gga ctc tac cac tgc att gcc act gag aac agc ttc aaa cag acc ata    2150
Gly Leu Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile 
    640                 645                 650                 

gcc aag atc aac ttc aaa gtt tta gat tca gaa atg gtg gcc gtt gtg    2198
Ala Lys Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val 
655                 660                 665                 670 

aca gac aag tgg tcc ccg tgg aca tgg gct ggc tct gtg agg gct cta    2246
Thr Asp Lys Trp Ser Pro Trp Thr Trp Ala Gly Ser Val Arg Ala Leu 
                675                 680                 685     

ccc ttc cat cca aag gac atc ctg ggg gca ttc agc cac tcg gaa atg    2294
Pro Phe His Pro Lys Asp Ile Leu Gly Ala Phe Ser His Ser Glu Met 
            690                 695                 700         

cag ctc atc aat cag tac tgc aaa gac acc cgg cag cag cag cag ctg    2342
Gln Leu Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln Gln Gln Leu 
        705                 710                 715             

ggg gaa gaa cca cag aag atg aga ggg gac tat ggc aag ctg aag gct    2390
Gly Glu Glu Pro Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala 
    720                 725                 730                 

ctc atc aac agc agg aaa agc aga aac agg agg aat cag ctt cca gag    2438
Leu Ile Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu 
735                 740                 745                 750 

tca taa aacattcatc catgaagttt tgcttccagg aacaaatgct ctgtcttcac     2494
Ser                                                            
                                                               

tagtcaacta ttaaataaaa tcttgtgctt tacccatgag aaatttctga caaaagctgg  2554

agactcactc taaagtgtgt tctctgtgaa ctgaaaagag catgcatttt cttgtatgat  2614

acagactagc actagacatg tcatggtcct tgtggtgcat aaaaaatatt taacttatcc  2674

cagattttat ttatatcttt atgtgtcttt tcttcaaaat caatgcgaca acagaagcag  2734

aactgttaca gcctcggttg agcgagggcc ataaatttcc ctgtgctctt ccttccgtgc  2794

tctaggggtt tagctttcta attgtcactg gcttttatac atgaaaaaga attccagttc  2854

acaattttca catagtaaat gtcatataaa tgtgtgtgac atccagtgtc atgtaggtta  2914

cacaaatgac agggaagaga gcatccagat gttacgtaaa gtcaagagtg actcataaag  2974

agcaagtgat gagttcatat gcttccagtg atttatcttc ttgcttgttc ctttgtttaa  3034

gattgtaaga tgtgtcggct gctgatagct gccatcaatg tttgttctct tgttttagaa  3094

aaacaaaaga aatggcctgt accatccaag gcctttgatg ggagatctat cagtgagcca  3154

ttgacgtttc tactgttatg ttatcatctt ccaaacaaaa gtgctttgtt tttttggaag  3214

ttatttaagt tattatagac ttacataaac tattgcatta tttaattgat ttactgtttt  3274

ggttttaatc ccctagtcta cctggaaaat taaagacaac aaggatgcag tattattaaa  3334

gcattcaact tttccatgca gagtgaagct atccaaaggg aaaaggaaga ttaaaaaaaa  3394

agcatacaat ttgtcatgta aaggaattag taacatgtag tttgttttct accttagtaa  3454

tcaaattcta ggagtaattt gtacatccaa ggaaccagtt tcacaaagca taatgatttt  3514

tcaggcaagg tttcatgatt tgtaaacata tctgtgatgg gaaagttatt attacatcaa  3574

gaaagaaaat ctcaacacat tttaaacaaa acagacttct tttaaagact atctattttc  3634

acccagatat tttttccact tgataatact tctttaggaa tgttgataca catgtttaac  3694

tattggaaaa ttttagcact atcttctaat tatatacttg gattgtttaa tgagaaaagt  3754

ataatactaa aattagtttc tccaatttaa atgaataaaa tataggagat tttcttatat  3814

gtcttttaat tatacaactt tcattttatt taattttatt ttaatatgtt tatattttca  3874

gataaaaaga gaagttttac taaaacacca ttgaaacata cttcttatta acagttcatc  3934

tagaatgtaa ctacagggga tctacatcat tttataatgc tgtggaaaaa cctgcaggaa  3994

gtaaaactat ggataggagt gtaagttggt agtagactac gtgtttagca tgcacaaaga  4054

cctgggctca aacagaaaga aaggaagaaa gacaccaagg aaggagggca agcaggaaaa  4114

agaacagact gactggagag aagaagggca ggaaagtggt aaagaaggca aagaaagatg  4174

gagggaatac attcattatc agaagattaa aaaatggtag ttaaatgatg gtcaattctg  4234

gtgttcttaa gagtgcacct cagtgttgta gaaaacacca gttaaaatag cataaatgta  4294

cccaaatgtg tacagtgcta caataatcta tggggttagc atatggttaa aatgtttggt  4354

tagcatgttt aaaatgttca cactttgggt tttcttatac atataaaaat agccatgcgt  4414

tcacgtgtga tgctaacacc atcctctttc tgtgtttgta attaatctat tgtatggaaa  4474

cagctacttc cccttgctcc acttaccttc aaactgccag ccacttggct attatttgtt  4534

ctatttagta cctcctgggt tggtttttaa ccataattac atttcaaatc ttcatttctt  4594

tttctttaaa gatatagaaa ttgctgtgca gcatagcccg gccaaaacta aaacatatat  4654

ctctcaaaag cataactaat acatattgag tatgggtgat tactcggttt tattttgttt  4714

acttgggaaa attaataatt aaacatgttt ttcttttgta ttgtacataa aattacctag  4774

aaatgcactt ttcctccaaa atgtaggttc gtgaatagac ttagcatgat gaagctgtct  4834

ttacagtgaa tgcttaccct gtgtagagaa agcaaactag atgtagttac cacatgagaa  4894

tttaattaga tgttgaaaaa aataatttgt ctggaaaaat aaagcattca attcccctga  4954

aa                                                                 4956

<210> 12
<211> 751
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:189..2444 from SEQ ID NO 11

<400> 12
Met Ala Phe Arg Ala Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      
Ile Cys Val Arg Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          
Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              
His Gln Gln Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  
Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  
Asn Ile Ser Gln Glu Pro Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      
Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         
Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             
Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 
Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 
Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     
Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         
Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             
Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 
Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 
Tyr Phe Phe Phe Lys Glu Arg Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     
Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         
Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             
Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 
Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 
Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     
Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         
Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             
Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 
Pro Asn Met Arg Thr Thr Lys Asp Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 
Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Arg 
                405                 410                 415     
Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         
Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             
Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 
Asn Ser Ser Ala Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 
Lys Asn His Val Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     
Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         
Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             
Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 
Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 
Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     
Glu Ile Val Gln Tyr Gly Val Arg Asn Asn Ser Thr Phe Leu Glu Cys 
            580                 585                 590         
Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             
Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 
Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Asp Ser Asp Gln Gly Leu 
625                 630                 635                 640 
Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     
Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         
Lys Trp Ser Pro Trp Thr Trp Ala Gly Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             
His Pro Lys Asp Ile Leu Gly Ala Phe Ser His Ser Glu Met Gln Leu 
    690                 695                 700                 
Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln Gln Gln Leu Gly Glu 
705                 710                 715                 720 
Glu Pro Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     
Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     

<210> 13
<211> 6276
<212> DNA
<213> Homo sapiens


<220> 
<223> wildtype full-length SEMA3D (>gi| 41406085|ref| NM_152754.2|)

<220> 
<221> CDS
<222> 41..2374
<223> /transl_table=1

<400> 13
attaaattaa caccatttga aagagaacat tgttttcatc atg aat gct aat aaa      55
                                            Met Asn Ala Asn Lys 
                                            1               5   

gat gaa aga ctt aaa gcc aga agc caa gat ttt cac ctt ttt cct gct     103
Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe His Leu Phe Pro Ala 
                10                  15                  20      

ttg atg atg cta agc atg acc atg ttg ttt ctt cca gtc act ggc act     151
Leu Met Met Leu Ser Met Thr Met Leu Phe Leu Pro Val Thr Gly Thr 
            25                  30                  35          

ttg aag caa aat att cca aga ctc aag cta acc tac aaa gac ttg ctg     199
Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr Tyr Lys Asp Leu Leu 
        40                  45                  50              

ctt tca aat agc tgt att ccc ttt ttg ggt tca tca gaa gga ctg gat     247
Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser Ser Glu Gly Leu Asp 
    55                  60                  65                  

ttt caa act ctt ctc tta gat gag gaa aga ggc agg ctg ctc ttg gga     295
Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly Arg Leu Leu Leu Gly 
70                  75                  80                  85  

gcc aaa gac cac atc ttt cta ctc agt ctg gtt gac tta aac aaa aat     343
Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val Asp Leu Asn Lys Asn 
                90                  95                  100     

ttt aag aag att tat tgg cct gct gca aag gaa cgg gtg gaa tta tgt     391
Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu Arg Val Glu Leu Cys 
            105                 110                 115         

aaa tta gct ggg aaa gat gcc aat aca gaa tgt gca aat ttc atc aga     439
Lys Leu Ala Gly Lys Asp Ala Asn Thr Glu Cys Ala Asn Phe Ile Arg 
        120                 125                 130             

gta ctt cag ccc tat aac aaa act cac ata tat gtg tgt gga act gga     487
Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr Val Cys Gly Thr Gly 
    135                 140                 145                 

gca ttt cat cca ata tgt ggg tat att gat ctt gga gtc tac aag gag     535
Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu Gly Val Tyr Lys Glu 
150                 155                 160                 165 

gat att ata ttc aaa cta gac aca cat aat ttg gag tct ggc aga ctg     583
Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu Glu Ser Gly Arg Leu 
                170                 175                 180     

aaa tgt cct ttc gat cct cag cag cct ttt gct tca gta atg aca gat     631
Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala Ser Val Met Thr Asp 
            185                 190                 195         

gag tac ctc tac tct gga aca gct tct gat ttc ctt ggc aaa gat act     679
Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe Leu Gly Lys Asp Thr 
        200                 205                 210             

gca ttc act cga tcc ctt ggg cct act cat gac cac cac tac atc aga     727
Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp His His Tyr Ile Arg 
    215                 220                 225                 

act gac att tca gag cac tac tgg ctc aat gga gca aaa ttt att gga     775
Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly Ala Lys Phe Ile Gly 
230                 235                 240                 245 

act ttc ttc ata cca gac acc tac aat cca gat gat gat aaa ata tat     823
Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp Asp Asp Lys Ile Tyr 
                250                 255                 260     

ttc ttc ttt cgt gaa tca tct caa gaa ggc agt acc tcc gat aaa acc     871
Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser Thr Ser Asp Lys Thr 
            265                 270                 275         

atc ctt tct cga gtt gga aga gtt tgt aag aat gat gta gga gga caa     919
Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn Asp Val Gly Gly Gln 
        280                 285                 290             

cgc agc ctg ata aac aag tgg acg act ttt ctt aag gcc aga ctg att     967
Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
    295                 300                 305                 

tgc tca att cct gga agt gat ggg gca gat act tac ttt gat gag ctt    1015
Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr Tyr Phe Asp Glu Leu 
310                 315                 320                 325 

caa gat att tat tta ctc ccc aca aga gat gaa aga aat cct gta gta    1063
Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu Arg Asn Pro Val Val 
                330                 335                 340     

tat gga gtc ttt act aca acc agc tcc atc ttc aaa ggc tct gct gtt    1111
Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe Lys Gly Ser Ala Val 
            345                 350                 355         

tgt gtg tat agc atg gct gac atc aga gca gtt ttt aat ggt cca tat    1159
Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val Phe Asn Gly Pro Tyr 
        360                 365                 370             

gct cat aag gaa agt gca gac cat cgt tgg gtg cag tat gat ggg aga    1207
Ala His Lys Glu Ser Ala Asp His Arg Trp Val Gln Tyr Asp Gly Arg 
    375                 380                 385                 

att cct tat cca cgg cct ggt aca tgt cca agc aaa acc tat gac cca    1255
Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Tyr Asp Pro 
390                 395                 400                 405 

ctg att aag tcc acc cga gat ttt cca gat gat gtc atc agt ttc ata    1303
Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp Val Ile Ser Phe Ile 
                410                 415                 420     

aag cgg cac tct gtg atg tat aag tcc gta tac cca gtt gca gga gga    1351
Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr Pro Val Ala Gly Gly 
            425                 430                 435         

cca acg ttc aag aga atc aat gtg gat tac aga ctg aca cag ata gtg    1399
Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg Leu Thr Gln Ile Val 
        440                 445                 450             

gtg gat cat gtc att gca gaa gat ggc cag tac gat gta atg ttt ctt    1447
Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Leu 
    455                 460                 465                 

gga aca gac att gga act gtc ctc aaa gtt gtc agc att tca aag gaa    1495
Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val Ser Ile Ser Lys Glu 
470                 475                 480                 485 

aag tgg aat atg gaa gag gta gtg ctg gag gag ttg cag ata ttc aag    1543
Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu Leu Gln Ile Phe Lys 
                490                 495                 500     

cac tca tca atc atc ttg aac atg gaa ttg tct ctg aag cag caa caa    1591
His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser Leu Lys Gln Gln Gln 
            505                 510                 515         

ttg tac att ggt tcc cga gat gga ttg gtt cag ctc tcc ttg cac aga    1639
Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln Leu Ser Leu His Arg 
        520                 525                 530             

tgc gac act tat ggg aaa gct tgc gca gac tgt tgt ctt gcc aga gac    1687
Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys Cys Leu Ala Arg Asp 
    535                 540                 545                 

ccc tac tgt gcc tgg gat gga aat gca tgc tct cga tat gct cct act    1735
Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser Arg Tyr Ala Pro Thr 
550                 555                 560                 565 

tct aaa agg aga gct aga cgc caa gat gta aaa tat ggc gac cca atc    1783
Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys Tyr Gly Asp Pro Ile 
                570                 575                 580     

acc cag tgc tgg gac atc gaa gac agc att agt cat gaa act gct gat    1831
Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser His Glu Thr Ala Asp 
            585                 590                 595         

gaa aag gtg att ttt ggc att gaa ttt aac tca acc ttt ctg gaa tgt    1879
Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser Thr Phe Leu Glu Cys 
        600                 605                 610             

ata cct aaa tcc caa caa gca act att aaa tgg tat atc cag agg tca    1927
Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp Tyr Ile Gln Arg Ser 
    615                 620                 625                 

ggg gat gag cat cga gag gag ttg aag ccc gat gaa aga atc atc aaa    1975
Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp Glu Arg Ile Ile Lys 
630                 635                 640                 645 

acg gaa tat ggg cta ctg att cga agt ttg cag aag aag gat tct ggg    2023
Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln Lys Lys Asp Ser Gly 
                650                 655                 660     

atg tat tac tgc aaa gcc cag gag cac act ttc atc cac acc ata gtg    2071
Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe Ile His Thr Ile Val 
            665                 670                 675         

aag ctg act ttg aat gtc att gag aat gaa cag atg gaa aat acc cag    2119
Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln Met Glu Asn Thr Gln 
        680                 685                 690             

agg gca gag cat gag gag ggg aag gtc aag gat cta ttg gct gag tca    2167
Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp Leu Leu Ala Glu Ser 
    695                 700                 705                 

cgg ttg aga tac aaa gac tac atc caa atc ctt agc agc cca aac ttc    2215
Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu Ser Ser Pro Asn Phe 
710                 715                 720                 725 

agc ctc gac cag tac tgc gaa cag atg tgg cac agg gag aag cgg aga    2263
Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His Arg Glu Lys Arg Arg 
                730                 735                 740     

cag aga aac aag ggg ggc cca aag tgg aag cac atg cag gaa atg aag    2311
Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His Met Gln Glu Met Lys 
            745                 750                 755         

aag aaa cga aat cga aga cat cac aga gac ctg gat gag ctc cct aga    2359
Lys Lys Arg Asn Arg Arg His His Arg Asp Leu Asp Glu Leu Pro Arg 
        760                 765                 770             

gct gta gcc acg tag ttttctactt aatttaaaga aaagaattcc ttacctataa    2414
Ala Val Ala Thr                                                 
    775                                                         

aaacattgcc ttctgttttg tatatccctt atagtaattc ataaatgctt cccatggagt  2474

tttgctaagg cacaagacaa taatctgaat aagacaatat gtgatgaata taagaaaggg  2534

caaaaaattc atttgaacca gttttccaag aacaaatctt gcacaagcaa agtataagaa  2594

ttatcctaaa aatagggggt ttacagttgt aaatgtttta tgttttgagt tttggaattt  2654

attgtcatgt aaatagttga gctaagcaag ccccgaattt gatagtgtat aaggtgcttt  2714

attccctcga atgtccatta agcatggaat ttaccatgca gttgtgctat gttcttatga  2774

acagatatat cattcctatt gagaaccagc taccttgtgg tagggaataa gaggtcagac  2834

acaaattaag acaactccca ttatcaacag gaactttctc agtgagccat tcactcctgg  2894

agaatggtat aggaatttgg agaggtgcat tatttctttc tggccactgg ggttaaattt  2954

agtgtactac aacattgatt tactgaaggg cactaatgtt tcccccagga tttctattga  3014

ctagtcagga gtaacaggtt cacagagaga agttggtgct tagttatgtg ttttttagag  3074

tatatactaa gctctacagg gacagaatgc ttaataaata ctttaataag atatgggaaa  3134

atattttaat aaaacaagga aaacataatg atgtataatg catcctgatg ggaaggcatg  3194

cagatgggat ttgttagaag acagaaggaa agacagccat aaattctggc tttggggaaa  3254

actcatatcc ccatgaaaag gaagaacaat cacaaataaa gtgagagtaa tgtaatggag  3314

ctcttttcac tagggtataa gtagctgcca atttgtaatt catctgttaa aaaaaatcta  3374

gattataaca aactgctagc aaaatctgag gaaacataaa ttcttctgaa gaatcatagg  3434

aagagtagac attttattta taaccaatga tatttcagta tatattttct ctcttttaaa  3494

aaatatttat catactctgt atattatttc tttttactgc ctttattctc tcctgtatat  3554

tggattttgt gattatattt gagtgaatag gagaaaacaa tatataacac acagagaatt  3614

aagaaaatga catttctggg gagtggggat atatatttgt tgaataacag aacgagtgta  3674

aaattttaac aacggaaagg gttaaattaa ctctttgaca tcttcactca accttttctc  3734

attgctgagt taatctgttg taattgtagt attgtttttg taatttaaca ataaataagc  3794

ctgctacatg taaaaagaac caaactcaca atattaacat aaacatcttt catattttgt  3854

tagtactttc aaatgttttc aatttgactt tccctctgaa tatgcatggt gtgtttcctg  3914

tctgtttaag cagaactcac ctttccttct tgtaacacag aacccttagc cttcttctgt  3974

tttgcctttt cacgcccttt atagtgtgaa atgaaaaatt agtcacttcc tcacatggaa  4034

ggcagctttt cagaaaataa cagacattgc tcgtttctca tgcattctac atatcttgaa  4094

agaaaagtct gtgagaaaac cctgtgatta gagggcaact taatgcaaga tctgtggctc  4154

tatgttgaga gcattctctc tctgttattt ttattttatt tgcattgctt acctatctca  4214

aagtagtcaa actgatatat gagattgagt actccctttt gatattatac tgatgaatat  4274

ttgtaggtgt ttcactataa ggaacagcta aggaataatt ttaataaaag tgaaccagaa  4334

caaatcactc atttaaaaag taattcagaa gaacagtgtg gcatgatcag acttctaatt  4394

gaatagcgta acaacagtgt ttgtaattat agatttgctt ggacaaaata ttccaggaac  4454

tcatagcgag ctcaaagcaa ttaagtggga acatttttaa tttaaaaaaa atttccaaat  4514

atttgtgggt ccgacagtaa tgatcaaaat atgaatgact ttggaaaatt tacatgaagc  4574

tcaagtgtta ggattgactt atgaaaataa attttatttc tatccaaatt tgaatgtcca  4634

aaccattttt tagttacttc tttctaatcc tagttattca gacaaaattt ggaaacttat  4694

tttatgacca catctaatat tctggctgct ttggatacaa tactcttgat ttatgataat  4754

tagttaaaat atattaaaaa tattattagt aaaataaaat ttcacacaat aaaaaacaac  4814

atagagtaca catatttata tgtattttta aagataaaga atatctaaaa tgtgtttttt  4874

tcttagcttt ttagttgtct agaacattta gagaaagagt atgaatatat taaatccaca  4934

aacacactat atacttcctc accactgact attttatcaa atttgcctta aaataatgaa  4994

aaagaaaagt atagttaatg gtttcaaata tgctaagaaa ttgactctgc ggaggggatc  5054

ttaaaatgcc tgtttactca tgttttcgta tttttcttgt ctctaatact tttgtctttg  5114

tctgccttgt gtgttctttt ctgaatttca tttcagcaat ttatgctgct aaatagaatc  5174

ccgcatgtct gcattcattt acattcaact tattgtaaat tttgagattt tatttagaaa  5234

tgaattgtct aattaattta tgtagagtcc ttttttccaa agagctcaaa acactacatc  5294

cacattattg acttttggaa accaaccaaa ttacttaaga aatggaaaag tagtcacaga  5354

gaaatttagt aatttgcaaa agccacaaca gtagtggaag aattaaaatt cataaagtct  5414

catcattctg ttggctaaaa taatgctctt tacaatatgc tggctacaaa atggtcttac  5474

tcttgaattt tgcttttggt tcatattttg gttcttcata ttctagtatg ttttgttcct  5534

gctgaatttt acagactcag ctaaacaata agttattagt agtcacttgt tttcattatc  5594

ataattgaat ttccaagaac aacttgatat cattcagctg tccaaaaaat aataagagca  5654

ttcattaaat actgattttc ttaaacttaa atgttgtatt tcatatttat ttatataata  5714

caaatggaaa tcaaaactga aatagcctcc ctttagaatg tcacattttt cttagaaaac  5774

attttggaat tggttaacct tattgggaat ggataattta gaaacaaacc aaaaaaaaaa  5834

aaagatattt gaagtgtttt tataggagat gtatttttat catagtaaat gatcacaatt  5894

ttaaataatt catcttacaa gtcaggtaaa ataaaatcga ttcccagatt ccatacatta  5954

ggagtgcaaa gacaggatca tacacatgac ttatacctct catttaaata ttttatagta  6014

taaagtattt atggaaaggg tttgagatag atgatttttg ggaaagggca aaatgtgtca  6074

gatgccctag ttaatcatgt aatttaattc tggtattgtg agtggttagc aatcaatttt  6134

gaatttataa ttctgctatt ttaaaagaaa tgtagtcttg tagtatgaaa taattaaaaa  6194

ttgttaaatg tatattttgg ttgtattata ataaaatgca aacatgactg ttctatgatt  6254

ataaaaaaaa aaaaaaaaaa aa                                           6276

<210> 14
<211> 777
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:41..2374 from SEQ ID NO 13

<400> 14
Met Asn Ala Asn Lys Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe 
1               5                   10                  15      
His Leu Phe Pro Ala Leu Met Met Leu Ser Met Thr Met Leu Phe Leu 
            20                  25                  30          
Pro Val Thr Gly Thr Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              
Tyr Lys Asp Leu Leu Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  
Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  
Arg Leu Leu Leu Gly Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val 
                85                  90                  95      
Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         
Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn Thr Glu Cys 
        115                 120                 125             
Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr 
    130                 135                 140                 
Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 
Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     
Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         
Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             
Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp 
    210                 215                 220                 
His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly 
225                 230                 235                 240 
Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         
Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             
Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 
Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 
Tyr Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     
Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         
Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             
Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 
Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 
Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     
Val Ile Ser Phe Ile Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         
Pro Val Ala Gly Gly Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             
Leu Thr Gln Ile Val Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 
Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 
Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     
Leu Gln Ile Phe Lys His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         
Leu Lys Gln Gln Gln Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln 
        515                 520                 525             
Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 
Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     
Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         
His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             
Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp 
    610                 615                 620                 
Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 
Glu Arg Ile Ile Lys Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     
Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         
Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             
Met Glu Asn Thr Gln Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp 
    690                 695                 700                 
Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 
Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His 
                725                 730                 735     
Arg Glu Lys Arg Arg Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His 
            740                 745                 750         
Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             
Asp Glu Leu Pro Arg Ala Val Ala Thr 
    770                 775         

<210> 15
<211> 6521
<212> DNA
<213> Mus musculus


<220> 
<223> wildtype full-length Sema3D (>gi| 282847343|ref| NM_028882.4|)

<220> 
<221> CDS
<222> 547..2880
<223> /transl_table=1

<400> 15
aaacccaccc tggacagcgc ggccgagaca gggaaggttt gctcgctctg agggattgcc    60

agcacatcag aagtggccgg gagctggggg aggagactga agggagaggt aatccctggc   120

gttttgagca tccccttttt agaaagaagg agtctctccc aggacagctg ctgcggtcac   180

accacaaact taaaagccgc cctcctgctt ggagcgtgcc tttcctcacc acgctcgctg   240

gcctaagcgc caactggtgg gtcactgtcc gagagagagg cgctgcgctc gggggacagg   300

agcgccccct gccttcccgc ttggccgtag ccgcggcctc attgctctgc cagggccgcc   360

tgtgcggggt tcagccccgg ctgccgctcc gaagaactcg cgcctgtgcc cgcggtcgcc   420

atcctcttgg cttccttggg ctgtcctttc ctctctcctg agcctgcgac gtaaggaaag   480

gaaaagcgac aagagttgct agcaggaagg gtgaactaac agtgtttgaa aaacaaaatt   540

ttcatc atg aat gtt act aaa gat gag aac cca aga tcc aga agt caa      588
       Met Asn Val Thr Lys Asp Glu Asn Pro Arg Ser Arg Ser Gln 
       1               5                   10                  

gat ctt cac ctt ttt cat gct tgg atg atg tta atc atg acg gtg ctc     636
Asp Leu His Leu Phe His Ala Trp Met Met Leu Ile Met Thr Val Leu 
15                  20                  25                  30  

ttt ctt cct gtc act gaa acg tct aaa caa aat att cca aga ctc aag     684
Phe Leu Pro Val Thr Glu Thr Ser Lys Gln Asn Ile Pro Arg Leu Lys 
                35                  40                  45      

cta acc tac aaa gac ttg ctg ctt tca aac acc tgt atc ccc ttt ttg     732
Leu Thr Tyr Lys Asp Leu Leu Leu Ser Asn Thr Cys Ile Pro Phe Leu 
            50                  55                  60          

ggt tca tca gaa gga ttg gat ttc cag act ctt ctt ttg gat gag gag     780
Gly Ser Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu 
        65                  70                  75              

agg ggc ata ctg ctc cta gga gcc aaa gac cat gtc ttc ctg ctc agt     828
Arg Gly Ile Leu Leu Leu Gly Ala Lys Asp His Val Phe Leu Leu Ser 
    80                  85                  90                  

ctg gtt gac ttg aac aag aat ttt aag aag att tat tgg cct gct gca     876
Leu Val Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala 
95                  100                 105                 110 

aaa gaa cga gtg gag cta tgt aaa tta gct ggg aaa gat gcc aat gca     924
Lys Glu Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn Ala 
                115                 120                 125     

gaa tgt gca aat ttc atc cgt gtg ctt caa ccc tat aat aag act cac     972
Glu Cys Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His 
            130                 135                 140         

gtt tac gtg tgt gga act gga gcg ttt cat ccg ctg tgt ggg tac att    1020
Val Tyr Val Cys Gly Thr Gly Ala Phe His Pro Leu Cys Gly Tyr Ile 
        145                 150                 155             

gat ctc ggc gcc aac aag gag gaa ctc ata ttt aaa cta gac acg cac    1068
Asp Leu Gly Ala Asn Lys Glu Glu Leu Ile Phe Lys Leu Asp Thr His 
    160                 165                 170                 

aac ctg gag tct ggc aga ctg aaa tgt ccc ttt gat cct cag cag cct    1116
Asn Leu Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro 
175                 180                 185                 190 

ttt gct tca gta atg aca gat gag cac ctc tac tct gga aca gct tct    1164
Phe Ala Ser Val Met Thr Asp Glu His Leu Tyr Ser Gly Thr Ala Ser 
                195                 200                 205     

gat ttc ctt ggc aaa gac act gca ttc aca agg tct ctg ggg cta atg    1212
Asp Phe Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Leu Met 
            210                 215                 220         

cag gac cac cat tcc atc aga act gac att tca gag cac cac tgg ctc    1260
Gln Asp His His Ser Ile Arg Thr Asp Ile Ser Glu His His Trp Leu 
        225                 230                 235             

aat gga gca aaa ttt atc gga aca ttc ccc att cca gac acc tat aat    1308
Asn Gly Ala Lys Phe Ile Gly Thr Phe Pro Ile Pro Asp Thr Tyr Asn 
    240                 245                 250                 

cca gat gat gat aaa ata tat ttc ttc ttt cga gaa tca tcc cag gaa    1356
Pro Asp Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu 
255                 260                 265                 270 

ggc agt act tct gac aga agc att ctt tca aga gtt gga aga gtt tgt    1404
Gly Ser Thr Ser Asp Arg Ser Ile Leu Ser Arg Val Gly Arg Val Cys 
                275                 280                 285     

aag aat gat gta ggt ggg caa cga agt ctg ata aac aaa tgg aca act    1452
Lys Asn Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr 
            290                 295                 300         

ttt cta aag gca aga ctg att tgc tcg att cct gga agc gat ggg gca    1500
Phe Leu Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala 
        305                 310                 315             

gat acc cat ttt gat gaa ctc caa gat att tac tta ctc cct acg aga    1548
Asp Thr His Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg 
    320                 325                 330                 

gat gaa aga aat cct gta gta tat gga gtc ttt acc aca acc agc tcc    1596
Asp Glu Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser 
335                 340                 345                 350 

atc ttc aaa ggc tct gct gtc tgt gtg tac agc atg gct gat atc cga    1644
Ile Phe Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg 
                355                 360                 365     

gca gtc ttt aat ggt ccc tat gct cat aag gaa agt gct gac cat cgc    1692
Ala Val Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg 
            370                 375                 380         

tgg gtg caa tat gat gga agg ata cct tac ccc cga cct gga acg tgt    1740
Trp Val Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys 
        385                 390                 395             

cca agc aaa acc tat gac cca ctg att aag tcc acc cga gac ttt cca    1788
Pro Ser Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro 
    400                 405                 410                 

gac gat gtt atc agt ttc ata agg cgg cac cct gtg atg tat aag tcc    1836
Asp Asp Val Ile Ser Phe Ile Arg Arg His Pro Val Met Tyr Lys Ser 
415                 420                 425                 430 

gtg tac cca gtg gca gga gca ccg acc ttc aag aga atc aac gtg gat    1884
Val Tyr Pro Val Ala Gly Ala Pro Thr Phe Lys Arg Ile Asn Val Asp 
                435                 440                 445     

tac aga ctg acg cag ata gtg gtg gat cac gtg gtc gct gaa gac ggg    1932
Tyr Arg Leu Thr Gln Ile Val Val Asp His Val Val Ala Glu Asp Gly 
            450                 455                 460         

cag tat gat gtc atg ttt ctc gga aca gac att gga aca gtc ctg aaa    1980
Gln Tyr Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys 
        465                 470                 475             

gtt gtg agc atc tcc aag gag aag tgg aat atg gaa gag gtc gta ctg    2028
Val Val Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu 
    480                 485                 490                 

gag gag ctt cag gta ttc aag cac cca aca gct atc ttg aac atg gag    2076
Glu Glu Leu Gln Val Phe Lys His Pro Thr Ala Ile Leu Asn Met Glu 
495                 500                 505                 510 

ttg tcg ctg aag cag caa cag ttg tac gtt ggt tcc tgg gat gga ttg    2124
Leu Ser Leu Lys Gln Gln Gln Leu Tyr Val Gly Ser Trp Asp Gly Leu 
                515                 520                 525     

gtc cag ctc tcc ttg cac aga tgc gac act tac ggg aaa gca tgt gca    2172
Val Gln Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala 
            530                 535                 540         

gac tgc tgt ctc gcc aga gac cct tac tgt gcc tgg gat gga aat gct    2220
Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala 
        545                 550                 555             

tgc tcc aga tat gca ccc acg tct aaa agg cga gct aga cgc cag gat    2268
Cys Ser Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp 
    560                 565                 570                 

gta aaa tat ggg gac cca atc act cag tgc tgg gac ata gaa gac agc    2316
Val Lys Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser 
575                 580                 585                 590 

att agt cat gaa aca gct gat gaa aag gtg att ttt gga att gaa ttt    2364
Ile Ser His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe 
                595                 600                 605     

aat tca acc ttt ttg gag tgt ata cct aaa tcc caa caa gcc tct gtt    2412
Asn Ser Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Ser Val 
            610                 615                 620         

gag tgg tac atc cag cgg tca gga gat gag cat cga gag gag ttg aaa    2460
Glu Trp Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys 
        625                 630                 635             

cct gat gaa agg atc atc aaa act gac tat ggg cta ctg att cga agt    2508
Pro Asp Glu Arg Ile Ile Lys Thr Asp Tyr Gly Leu Leu Ile Arg Ser 
    640                 645                 650                 

ctg cag aag aag gat tct ggg atg tat tac tgc aaa gca cag gag cac    2556
Leu Gln Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His 
655                 660                 665                 670 

act ttc atc cac acc ata gtg aag ctg act ttg aat gtc att gag aat    2604
Thr Phe Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn 
                675                 680                 685     

gaa cag atg gaa aat acc cag agg gca gaa tac cag gag ggg cag gtc    2652
Glu Gln Met Glu Asn Thr Gln Arg Ala Glu Tyr Gln Glu Gly Gln Val 
            690                 695                 700         

aag gat ctg ttg gct gag tca cgg ttg aga tac aaa gac tac atc caa    2700
Lys Asp Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln 
        705                 710                 715             

atc ctt agc agc ccg aac ttc agc ctg gac cag tac tgt gag cag atg    2748
Ile Leu Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met 
    720                 725                 730                 

tgg tac aag gag aag cgg aga cag cgc aac aag ggc agc cca aag tgg    2796
Trp Tyr Lys Glu Lys Arg Arg Gln Arg Asn Lys Gly Ser Pro Lys Trp 
735                 740                 745                 750 

aag cac atg cag gaa atg aag aag aaa cga aat cga cga cat cac aga    2844
Lys His Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg 
                755                 760                 765     

gac ctc gat gag ctc cag aga tca gta gct aca tag ttttctattt         2890
Asp Leu Asp Glu Leu Gln Arg Ser Val Ala Thr                
            770                 775                        

aatttaaaga gggaattatt tacctgcctg cacaaataat gtcttctgtt ttgtacatcc  2950

cttatactaa ctcatacatg cttcccatgg agtctcacgg aggcacagga tgctatgctg  3010

agtaagacta tataggacat catctgaacc agctttccaa gaacaaaatc tgtatcagca  3070

aagttaagaa ttgtcttaaa aataggggcc ttatgtttgt aaatgtctca tagtttgaat  3130

ttaatgtcat gtaaataatc aagttaaatg aacccaggtc cacttagtaa gggcgttatt  3190

cccgtgcatg tccattaagc atggactttc ccatgctgct ggctatgtgc ttaatcattc  3250

cattctagaa caggtgatca tgtaggaact ggagaaaagg cacactttaa aacagcttat  3310

gttagcaaaa aaaaaacttt ctcaaggagc caacaggcca cacttggagt caggcgtggg  3370

aatttagaaa ggcatgttcc ctctttgtgg accaggctac atctagtgta ctgcagtaat  3430

gctctgtgag agggtagtaa tgatcctcac caatttcctt ttgattgctc aagcacagca  3490

tcatggacag aaccccatgg tgtgctctag agtacagaca atggaactta gtacacactt  3550

cctgtgctct ttgggaagca tggtaaaaga tcttaatata ataataaggg tgacatgata  3610

tacactgtat cctaatctgt agatgggaat tatttggaga cagacaagat agctgtaaat  3670

tctgtctctg agaaaaactt atattgccat aaaaaaggag aaagccacaa agtagataga  3730

atgtaatgga attctttcca ctggagtata aatatctgcc aacttataat gttttggtta  3790

aaaataattt agattatagc aaattgttag caaaaatgca agtgaaagta aaatttgtaa  3850

aaaaaattat gggatggcaa tatattattt ataaccaatg tatttctgtg ttctcttttt  3910

ttctaagtat ttatcgtatt ctgtatattg tttgcattta catccttttt tttattatat  3970

ttgagtaaat aggagaaagc aatacgtaat acatagagat aattgagtag atgaccaagg  4030

tggggagtgg ggctatatat ttgttgaatg gatggataat ggcaaaattt tgatgacggg  4090

aagggttaaa ttaactcttc gacatcctct cgttacataa actttcaagc agtgttgttt  4150

tcagcagttt cacaaggaag tcttcaacat ctaaagaaaa cactcacacc gttagcataa  4210

gtaccatttg tattttgcta gcctgtgtca aattcaactt tgcctttgaa cagtgttttc  4270

ctgccagtct ctccagaaat caactttcct tcctgtagca caaaaccctt agccttcctc  4330

tgttttgcct tttcacgctc tttatagtgt gaaatgaaca attagtcact tcctcacaaa  4390

gaatgcagct ttttagaaaa ccaacagacc ttgtttgttt ctcatgcatt ctacatgttt  4450

tgaaagattc tgtgagaagc ctgtgtgatt aaaaagcagt tttacagagt caagcaatct  4510

atctcttcaa agtagcatca gtattttaca ttcatttaat ttgcattggg tacctatctc  4570

aagggcataa cattatctgc aagggactag tataataatg aatatttgtt gatgtttcac  4630

tcttggaaaa agcaaaaatg aaggaacaat tttaatttgt aaaccagaat gaatcacatc  4690

tccagcagaa gtgcatacaa atccttgtgt catggttaga ctactaatca tagatcacac  4750

aataatgttt atctactggc ttactgagtc ctgcaaagtc acagcaaaca tgtcagtggg  4810

tgcatgcttc attcaaaaaa tgctttcaga tagctgtgca tcagagagta atactcaaat  4870

atcagtagta ttgaaagatt gcacaagatt ctactctttg tattgacatc tgaaaattaa  4930

ttttatatag ataataatgt ccaaactatt ttctaattac ttatgtaatt agaaatgtaa  4990

tgttttatca acattctgta aatctatttt acatcttaga tttaaaattt tggctgtttt  5050

gggcataaaa cttctaatta tgattaaata tattataaac attattagga aaatatgatt  5110

ccataataaa ggtagggcta tggtttattt tgaaatgcag actatagcta agcagcattc  5170

attcttattc aaaagactta gaagagtgtt gtgaaagatc agttgacaaa tgtaatgtgt  5230

agttccttac cattgaggat gaacaactct gttttgaaat aataaaaagc agaatattgc  5290

tcaaagttta aatattaaag gtaccagatc ccccagaagc aactctgaac tatgtagtta  5350

ttcatttttt tttaaatcta tttttctgtc ttcagtacaa gtctctagct tctgtgagtg  5410

tttttgctgc atttttattc agtcctttgt gctgctaaat agtagtatgc ctgaatgagt  5470

taatttacat ttaatttatt gggaatttta agagtttgtt tagaaatgga taatctaaat  5530

aagcaattta tgtaaaatcc tttgtttttc tttcccaaaa gagttcataa tcatatatca  5590

cacgacagag taaacatttc agaagaaaca gtcaagttac ttaaaaaact gcaaagtagt  5650

catagaaaaa ctgagcacac tgcagaatcc acaatagctc tcggatgcac aattccagga  5710

tgatttgttt aaagcaagac ttacttacaa catgcctgca atatgatggt cacgcttttg  5770

gacgtttcct ttgtgctata ctttgattct ttgcatatat taattattac atgctattcc  5830

tactgaattg gtgatcttac ctagaggcta acaagagtga ctacttgtta gactaacata  5890

accaagaata atttcccagg acaacttgtg tcatttcatt cacatgaaaa aataaaatta  5950

aacaagacca ctcagtaaac attgattctt cttaaacata tgtctaagat gtattgtaca  6010

tattttactg aaacagaata aagttaactt gggaatccct tctcttcata ataccacatt  6070

gttgcagtca gtgtgtttca actaacaagc cattttgagg gatgggtaac tttttaaaaa  6130

tagaaatgta tattttctca taatagatga tcacaatatt tcaatttaca gtatgtaagg  6190

ttaaaaatac ataagactta aattttccag acttgttaaa ctgaaaatcc atgtacacaa  6250

taaatctcac gctttgtaac tcttgcttaa atcttttgta atgtaaggta tttatgaaaa  6310

tttgaagcat acctttttgg gaaagaaaaa taaaacctgt cagaagccac agttggtctt  6370

cacttcttag cattgtcagt ggtgggtatc aatgaatttg aataatttta cttttaaaaa  6430

actgtagtct tgtagtatag catacttaaa attgttaaat gtatattttg tttgtattat  6490

aataaaacaa gtatcagtgt tctattatta t                                 6521

<210> 16
<211> 777
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:547..2880 from SEQ ID NO 15

<400> 16
Met Asn Val Thr Lys Asp Glu Asn Pro Arg Ser Arg Ser Gln Asp Leu 
1               5                   10                  15      
His Leu Phe His Ala Trp Met Met Leu Ile Met Thr Val Leu Phe Leu 
            20                  25                  30          
Pro Val Thr Glu Thr Ser Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              
Tyr Lys Asp Leu Leu Leu Ser Asn Thr Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  
Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  
Ile Leu Leu Leu Gly Ala Lys Asp His Val Phe Leu Leu Ser Leu Val 
                85                  90                  95      
Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         
Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn Ala Glu Cys 
        115                 120                 125             
Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Val Tyr 
    130                 135                 140                 
Val Cys Gly Thr Gly Ala Phe His Pro Leu Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 
Gly Ala Asn Lys Glu Glu Leu Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     
Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         
Ser Val Met Thr Asp Glu His Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             
Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Leu Met Gln Asp 
    210                 215                 220                 
His His Ser Ile Arg Thr Asp Ile Ser Glu His His Trp Leu Asn Gly 
225                 230                 235                 240 
Ala Lys Phe Ile Gly Thr Phe Pro Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         
Thr Ser Asp Arg Ser Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             
Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 
Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 
His Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     
Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         
Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             
Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 
Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 
Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     
Val Ile Ser Phe Ile Arg Arg His Pro Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         
Pro Val Ala Gly Ala Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             
Leu Thr Gln Ile Val Val Asp His Val Val Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 
Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 
Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     
Leu Gln Val Phe Lys His Pro Thr Ala Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         
Leu Lys Gln Gln Gln Leu Tyr Val Gly Ser Trp Asp Gly Leu Val Gln 
        515                 520                 525             
Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 
Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     
Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         
His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             
Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Ser Val Glu Trp 
    610                 615                 620                 
Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 
Glu Arg Ile Ile Lys Thr Asp Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     
Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         
Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             
Met Glu Asn Thr Gln Arg Ala Glu Tyr Gln Glu Gly Gln Val Lys Asp 
    690                 695                 700                 
Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 
Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp Tyr 
                725                 730                 735     
Lys Glu Lys Arg Arg Gln Arg Asn Lys Gly Ser Pro Lys Trp Lys His 
            740                 745                 750         
Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             
Asp Glu Leu Gln Arg Ser Val Ala Thr 
    770                 775         

<210> 17
<211> 2328
<212> DNA
<213> Homo sapiens


<220> 
<223> Codon optimized cDNA sequence Human SEMA3A A106K delta Ig-b

<220> 
<221> CDS
<222> 1..2328
<223> /transl_table=1

<400> 17
atg gga tgg ctg acc aga atc gtg tgc ctg ttc tgg ggc gtg ctg ctg      48
Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      

acc gcc aga gcc aac tac cag aac ggc aag aac aac gtg ccc cgg ctg      96
Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          

aag ctg agc tac aaa gag atg ctg gaa agc aac aac gtg atc acc ttc     144
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              

aac ggc ctg gcc aac agc agc agc tac cac acc ttt ctg ctg gac gag     192
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  

gaa cgg tcc cgg ctg tac gtg gga gcc aag gac cac atc ttc agc ttc     240
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  

gac ctc gtg aac atc aag gac ttc cag aaa atc gtg tgg ccc gtg tcc     288
Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      

tac acc aga cgg gac gag tgc aag tgg aag ggc aag gac atc ctg aaa     336
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         

gag tgc gcc aac ttc atc aag gtg ctg aag gcc tac aac cag acc cac     384
Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             

ctg tac gcc tgt ggc acc ggc gcc ttc cac cct atc tgc acc tac atc     432
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 

gag atc ggc cac cac ccc gag gac aat atc ttc aag ctg gaa aac agc     480
Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 

cac ttc gag aac ggc aga ggc aag agc ccc tac gac ccc aag ctg ctg     528
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     

aca gcc tcc ctg ctg atc gac ggc gag ctg tac tct ggc aca gcc gcc     576
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         

gac ttc atg ggc cgg gac ttc gcc atc ttc aga acc ctg gga cac cac     624
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             

cac cca atc cgg acc gag cag cac gac agc aga tgg ctg aac gac cct     672
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 

aag ttc atc agc gcc cac ctg atc agc gag agc gac aac cct gag gac     720
Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 

gac aag gtg tac ttc ttc ttc cgg gaa aac gcc atc gac ggg gag cac     768
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     

agc gga aag gcc aca cac gcc aga atc ggc cag atc tgc aag aac gac     816
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         

ttc ggc ggc cac cgg tcc ctc gtg aac aag tgg acc acc ttc ctg aag     864
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             

gcc cgg ctg atc tgt agc gtg cca ggc ccc aat ggc atc gac acc cac     912
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 

ttc gac gag ctg cag gac gtg ttc ctg atg aat ttc aag gac ccc aag     960
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 

aac ccc gtg gtg tac ggc gtg ttc acc acc agc agc aac atc ttc aag    1008
Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     

ggc agc gcc gtg tgc atg tac agc atg agc gac gtg cgg cgg gtg ttc    1056
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         

ctg gga cct tac gcc cat aga gat ggc ccc aat tac cag tgg gtg ccc    1104
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             

tac cag ggc aga gtg cct tac ccc aga cct ggc acc tgt ccc agc aag    1152
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 

acc ttt ggc ggc ttc gac agc acc aag gac ctg ccc gac gat gtg att    1200
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 

acc ttc gcc aga tcc cac ccc gcc atg tac aac ccc gtg ttc ccc atg    1248
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     

aac aac cgg ccc atc gtg atc aag acc gac gtg aac tac cag ttc acc    1296
Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         

cag atc gtg gtg gac aga gtg gac gcc gag gac ggc cag tac gac gtg    1344
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             

atg ttc atc ggc acc gac gtg ggc acc gtg ctg aaa gtg gtg tcc atc    1392
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 

ccc aaa gag act tgg tac gac ctg gaa gag gtg ctg ctg gaa gag atg    1440
Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 

acc gtg ttc aga gag ccc acc gcc atc tcc gcc atg gaa ctg agc aca    1488
Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     

aag cag cag cag ctg tac atc ggc agc aca gct ggc gtg gca cag ctg    1536
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         

cct ctg cac aga tgc gac atc tac ggc aag gcc tgc gcc gag tgt tgc    1584
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             

ctg gcc aga gat cct tac tgc gcc tgg gat ggc agc gcc tgc agc aga    1632
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 

tac ttc ccc acc gac aag acc cac aca tgc ccc cct tgt cct gcc cct    1680
Tyr Phe Pro Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
545                 550                 555                 560 

gaa ctg ctg gga ggc ccc tcc gtg ttt ctg ttc ccc cca aag ccc aag    1728
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                565                 570                 575     

gat acc ctg atg atc agc aga acc ccc gaa gtg acc tgc gtg gtg gtg    1776
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            580                 585                 590         

gac gtg tcc cac gag gac cct gaa gtg aag ttc aat tgg tac gtg gac    1824
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        595                 600                 605             

ggc gtg gaa gtg cac aac gcc aag acc aag ccc aga gag gaa cag tac    1872
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    610                 615                 620                 

aac agc acc tac cgc gtg gtg tcc gtg ctg acc gtg ctg cac cag gac    1920
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
625                 630                 635                 640 

tgg ctg aat ggc aaa gag tac aag tgc aag gtg tcc aac aag gcc ctg    1968
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                645                 650                 655     

cct gcc ccc atc gag aaa acc atc agc aag gcc aag ggc cag ccc cgc    2016
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            660                 665                 670         

gaa ccc cag gtg tac aca ctg ccc cct agc agg gac gag ctg acc aag    2064
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        675                 680                 685             

aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac ccc tcc gat    2112
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    690                 695                 700                 

atc gcc gtg gaa tgg gag agc aac ggc cag ccc gag aac aac tac aag    2160
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
705                 710                 715                 720 

acc acc ccc cct gtg ctg gac agc gac ggc tca ttc ttc ctg tac agc    2208
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                725                 730                 735     

aag ctg aca gtg gac aag agc cgg tgg cag cag ggc aac gtg ttc agc    2256
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            740                 745                 750         

tgc agc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc    2304
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        755                 760                 765             

ctg agc ctg agc ccc ggc aaa tga                                    2328
Leu Ser Leu Ser Pro Gly Lys     
    770                 775     

<210> 18
<211> 775
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:1..2328 from SEQ ID NO 17

<400> 18
Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     
Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 
Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
545                 550                 555                 560 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                565                 570                 575     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            580                 585                 590         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        595                 600                 605             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    610                 615                 620                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
625                 630                 635                 640 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                645                 650                 655     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            660                 665                 670         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        675                 680                 685             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    690                 695                 700                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
705                 710                 715                 720 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                725                 730                 735     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            740                 745                 750         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        755                 760                 765             
Leu Ser Leu Ser Pro Gly Lys 
    770                 775 

<210> 19
<211> 2313
<212> DNA
<213> Mus musculus


<220> 
<223> Codon optimized cDNA sequence Mouse Sema3A A106K delta Ig-b

<220> 
<221> CDS
<222> 1..2313
<223> /transl_table=1

<400> 19
atg gga tgg ttt act gga att gcc tgt ctg ttt tgg gga gtg ctt ctg      48
Met Gly Trp Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      

act gcc aga gca aat tac gcc aat ggc aag aac aac gtc ccc aga ctg      96
Thr Ala Arg Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          

aag ctc tct tac aag gag atg ctg gag tct aac aat gtg att aca ttc     144
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              

aat ggc ctt gcc aac tct tcc tca tac cac acc ttt ctg ctg gat gag     192
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  

gag cgc tca cgg ctg tat gtg gga gcc aag gac cat att ttc agt ttt     240
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  

aat ctc gtg aat atc aag gat ttt cag aag atc gta tgg cct gtc tca     288
Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      

tat acc cgc aga gac gag tgc aaa tgg aag ggc aaa gat ata ctg aag     336
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         

gaa tgc gca aat ttc att aag gtg ctc gag gca tac aac cag aca cac     384
Glu Cys Ala Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His 
        115                 120                 125             

ttg tat gcc tgt ggg act ggc gcg ttc cat cct att tgt aca tac atc     432
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 

gag gtg gga cat cat ccg gag gac aac atc ttc aag ttg cag gat agc     480
Glu Val Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser 
145                 150                 155                 160 

cac ttc gag aac ggc agg gga aag tca cct tac gac cca aaa ctc ctg     528
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     

act gct tcc ctg ctt atc gac ggt gaa ctc tac tct ggc acc gca gcc     576
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         

gac ttt atg ggc aga gac ttt gct ata ttc agg acc ctc gga cat cat     624
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             

cat ccg att cgg acc gag caa cac gac tca cgc tgg ctg aat gac ccc     672
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 

aga ttc att tca gcc cac ctg atc ccc gaa agt gat aac cca gag gac     720
Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 

gac aaa gta tac ttc ttc ttt cgc gag aat gct ata gac ggc gag cac     768
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     

agc gga aag gct act cat gct cgg atc ggg caa atc tgt aaa aac gat     816
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         

ttt gga ggc cat cga tca ttg gtt aac aag tgg acc aca ttt ctt aaa     864
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             

gca aga ctt atc tgc tct gtg cct ggt cca aac ggg ata gat act cat     912
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 

ttc gac gag ctg cag gac gtg ttc ctt atg aac agt aag gac ccg aag     960
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 

aac cct atc gtg tac gga gtt ttt acg acg tcc tcc aac atc ttc aag    1008
Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     

ggc tca gca gtc tgc atg tat agc atg agc gac gtc cgg agg gtc ttc    1056
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         

ctc gga ccc tac gca cac cgc gat ggc ccc aat tat cag tgg gtt cct    1104
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             

tat caa ggg aga gta cct tac cct aga cca ggg aca tgt cca tcc aag    1152
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 

aca ttc gga ggt ttt gat tca acc aag gac ttg cca gac gat gtc ata    1200
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 

acc ttc gcc aga tca cac ccc gcc atg tac aat cct gtt ttt ccg att    1248
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     

aac aac cgc ccc att atg atc aaa act gat gtg aac tat caa ttc acc    1296
Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         

cag att gtt gta gat aga gtt gat gct gag gat ggc cag tat gat gtc    1344
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             

atg ttc atc ggt aca gac gtg gga aca gtc ttg aaa gtc gtt tct gtc    1392
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val 
    450                 455                 460                 

cct aaa gag acc tgg cac gac ctg gaa gag gtc ctc ctg gag gag atg    1440
Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 

aca gtg ttc cgg gag ccc acc aca atc agc gcc atg gaa ctc tct acc    1488
Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     

aag cag cag cag ctc tac atc ggt tcc aca gct ggg gtg gct cag ctt    1536
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         

ccc ctc cac aga tgc gac ata tac ggg aag gcc tgt gct gag tgc tgc    1584
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             

ctg gcc aga gat ccc tac tgc gcg tgg gat ggt tca agt tgc agt cga    1632
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 

tac ttc ccc aca ggg tgc aag cct tgt att tgt act gtg ccc gaa gtg    1680
Tyr Phe Pro Thr Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
545                 550                 555                 560 

tcc tcc gtg ttc atc ttt cca ccc aag cct aag gac gtt ttg aca ata    1728
Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
                565                 570                 575     

acg ctg acc cca aag gtg acg tgc gtt gtg gtc gat atc agc aag gac    1776
Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
            580                 585                 590         

gat cca gaa gtc cag ttt tct tgg ttt gtt gat gat gtg gaa gta cac    1824
Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
        595                 600                 605             

act gcg caa aca cag cct agg gaa gag cag ttt aac tct act ttt agg    1872
Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    610                 615                 620                 

agc gta agc gag ctg ccg att atg cat cag gac tgg ttg aat ggg aag    1920
Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
625                 630                 635                 640 

gag ttc aaa tgt cgc gtt aac tcc gca gcc ttc ccc gca cct atc gaa    1968
Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
                645                 650                 655     

aaa acg atc tca aag act aag ggt agg cca aaa gcg cca cag gta tac    2016
Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
            660                 665                 670         

acc att cct cca ccg aag gaa cag atg gca aaa gat aag gtt tca ctg    2064
Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
        675                 680                 685             

aca tgc atg att act gac ttt ttc ccc gag gat atc acc gtg gaa tgg    2112
Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
    690                 695                 700                 

cag tgg aat ggc caa ccc gca gag aac tat aag aac act caa cca att    2160
Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
705                 710                 715                 720 

atg gac aca gac ggc tca tat ttc gtg tac tct aag ctg aat gtc cag    2208
Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
                725                 730                 735     

aag tca aat tgg gaa gct gga aac acg ttt acc tgt agt gtg ttg cat    2256
Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
            740                 745                 750         

gag gga ctg cac aac cat cat acc gaa aag tca ttg tcc cat agc cca    2304
Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
        755                 760                 765             

gga aag tga                                                        2313
Gly Lys     
    770     

<210> 20
<211> 770
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:1..2313 from SEQ ID NO 19

<400> 20
Met Gly Trp Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Val Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     
Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val 
    450                 455                 460                 
Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
545                 550                 555                 560 
Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
                565                 570                 575     
Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
            580                 585                 590         
Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
        595                 600                 605             
Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    610                 615                 620                 
Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
625                 630                 635                 640 
Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
                645                 650                 655     
Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
            660                 665                 670         
Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
        675                 680                 685             
Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
    690                 695                 700                 
Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
705                 710                 715                 720 
Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
                725                 730                 735     
Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
            740                 745                 750         
Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
        755                 760                 765             
Gly Lys 
    770 

<210> 21
<211> 202
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 96-297

<400> 21
Ser Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu 
1               5                   10                  15      
Lys Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr 
            20                  25                  30          
His Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr 
        35                  40                  45              
Ile Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn 
    50                  55                  60                  
Ser His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu 
65                  70                  75                  80  
Leu Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala 
                85                  90                  95      
Ala Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His 
            100                 105                 110         
His His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp 
        115                 120                 125             
Pro Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu 
    130                 135                 140                 
Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu 
145                 150                 155                 160 
His Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn 
                165                 170                 175     
Asp Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu 
            180                 185                 190         
Lys Ala Arg Leu Ile Cys Ser Val Pro Gly 
        195                 200         

<210> 22
<211> 203
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 95-297

<400> 22
Pro Val Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly 
1               5                   10                  15      
Thr Glu Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr 
            20                  25                  30          
His Leu Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe 
        35                  40                  45              
Val Glu Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro 
    50                  55                  60                  
Gly Arg Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His 
65                  70                  75                  80  
Arg Ala Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala 
                85                  90                  95      
Ala Asp Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln 
            100                 105                 110         
Arg Pro Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu 
        115                 120                 125             
Pro Lys Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp 
    130                 135                 140                 
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala 
145                 150                 155                 160 
Pro Ala Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg 
                165                 170                 175     
Asn Asp Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe 
            180                 185                 190         
Leu Lys Ala Arg Leu Val Cys Ser Val Pro Gly 
        195                 200             

<210> 23
<211> 201
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 94-294

<400> 23
Ser Thr Ile Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr 
1               5                   10                  15      
His Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr 
            20                  25                  30          
His Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr 
        35                  40                  45              
Leu Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser 
    50                  55                  60                  
Lys Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn 
65                  70                  75                  80  
Thr Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile 
                85                  90                  95      
Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg 
            100                 105                 110         
Asn Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro 
        115                 120                 125             
Met Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp 
    130                 135                 140                 
Ala Lys Val Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg 
145                 150                 155                 160 
Ser Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp 
                165                 170                 175     
Thr Gly Gly Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
            180                 185                 190         
Ala Arg Leu Val Cys Ser Val Thr Asp 
        195                 200     

<210> 24
<211> 205
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 110-314

<400> 24
Ala Lys Glu Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn 
1               5                   10                  15      
Thr Glu Cys Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr 
            20                  25                  30          
His Ile Tyr Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr 
        35                  40                  45              
Ile Asp Leu Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr 
    50                  55                  60                  
His Asn Leu Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln 
65                  70                  75                  80  
Pro Phe Ala Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala 
                85                  90                  95      
Ser Asp Phe Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro 
            100                 105                 110         
Thr His Asp His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp 
        115                 120                 125             
Leu Asn Gly Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr 
    130                 135                 140                 
Asn Pro Asp Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln 
145                 150                 155                 160 
Glu Gly Ser Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val 
                165                 170                 175     
Cys Lys Asn Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr 
            180                 185                 190         
Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly 
        195                 200                 205 

<210> 25
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 104-113

<400> 25
Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu 
1               5                   10  

<210> 26
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 214-221

<400> 26
Glu Gln His Asp Ser Arg Trp Leu 
1               5               

<210> 27
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 274-287

<400> 27
Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu 
1               5                   10                  

<210> 28
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 103-112

<400> 28
Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
1               5                   10  

<210> 29
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 213-220

<400> 29
Glu Pro His Asp Ser Arg Trp Leu 
1               5               

<210> 30
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 274-287

<400> 30
Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu 
1               5                   10                  

<210> 31
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 102-111

<400> 31
Lys Met Ala Gly Lys Asp Pro Thr His Gly 
1               5                   10  

<210> 32
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 211-218

<400> 32
Asp Gln His Asn Ser Lys Trp Leu 
1               5               

<210> 33
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 271-284

<400> 33
Gly Gly Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu 
1               5                   10                  

<210> 34
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 118-127

<400> 34
Lys Leu Ala Gly Lys Asp Ala Asn Thr Glu 
1               5                   10  

<210> 35
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 231-238

<400> 35
Asp Ile Ser Glu His Tyr Trp Leu 
1               5               

<210> 36
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 291-304

<400> 36
Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
1               5                   10                  

<210> 37
<211> 990
<212> DNA
<213> Homo sapiens


<220> 
<223> immunoglobulin heavy chain constant region gamma 1 (IGHG1 gene)
      (>gi| 12054071|ref| AJ294730.1|)

<220> 
<221> CDS
<222> 1..990
<223> /transl_table=1

<400> 37
gca agc ttc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag     48
Ala Ser Phe Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac     96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc    144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc    192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc    240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag    288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc    336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca    384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc    432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg    480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag    528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg    576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac    624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg    672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag    720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat    768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac    816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc    864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac    912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg    960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

cag aag agc ctc tcc ctg tct ccg ggt aaa                            990
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 38
<211> 330
<212> PRT
<213> Homo sapiens


<220> 
<223> [CDS]:1..990 from SEQ ID NO 37

<400> 38
Ala Ser Phe Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 39
<211> 1047
<212> DNA
<213> Mus musculus


<220> 
<223> hybridoma 36-35 immunoglobulin heavy chain constant region,
      partial cds (>gi| 195165|ref| M60435.1|)

<220> 
<221> CDS
<222> 1..975
<223> /transl_table=1

<400> 39
gcc aaa acg aca ccc cca tct gtc tat cca ctg gcc cct gga tct gct      48
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      

gcc caa act aac tcc atg gtg acc ctg gga tgc ctg gtc aag ggc tat      96
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          

ttc cct gag cca gtg aca gtg acc tgg aac tct gga tcc ctg tcc agc     144
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              

ggt gtg cac acc ttc cca gct gtc ctg cag tct gac ctc tac act ctg     192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  

agc agc tca gtg act gtc ccc tcc agc acc tgg ccc agc gag acc gtc     240
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  

acc tgc aac gtt gcc cac ccg gcc agc agc acc aag gtg gac aag aaa     288
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      

att gtg ccc agg gat tgt ggt tgt aag cct tgc ata tgt aca gtc cca     336
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         

gaa gta tca tct gtc ttc atc ttc ccc cca aag ccc aag gat gtg ctc     384
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             

acc att act ctg act cct aag gtc acg tgt gtt gtg gta gac atc agc     432
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 

aag gat gat ccc gag gtc cag ttc agc tgg ttt gta gat gat gtg gag     480
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 

gtg cac aca gct cag acg caa ccc cgg gag gag cag ttc aac agc act     528
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     

ttc cgc tca gtc agt gaa ctt ccc atc atg cac cag gac tgg ctc aat     576
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         

ggc aag gag ttc aaa tgc agg gtc aac agt gca gct ttc cct gcc ccc     624
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             

atc gag aaa acc atc tcc aaa acc aaa ggc aga ccg aag gct cca cag     672
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 

gtg tac acc att cca cct ccc aag gag cag atg gcc aag gat aaa gtc     720
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 

agt ctg acc tgc atg ata aca gac ttc ttc cct gaa gac att act gtg     768
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     

gag tgg cag tgg aat ggg cag cca gcg gag aac tac aag aac act cag     816
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         

ccc atc atg gac aca gat ggc tct tac ttc gtc tac agc aag ctc aat     864
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             

gtg cag aag agc aac tgg gag gca gga aat act ttc acc tgc tct gtg     912
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 

tta cat gag ggc ctg cac aac cac cat act gag aag agc ctc tcc cac     960
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 

tct cct ggt aaa tga tctcagtgtc cttggagccc tctggtccta caggactctg    1015
Ser Pro Gly Lys                                                 
                                                                

acacctacct ccacccctcc ctgtgtaaat aa                                1047

<210> 40
<211> 324
<212> PRT
<213> Mus musculus


<220> 
<223> [CDS]:1..975 from SEQ ID NO 39

<400> 40
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 
Ser Pro Gly Lys 
                

<210> 41
<211> 232
<212> PRT
<213> Homo sapiens


<220> 
<223> Human immunoglobulin heavy chain constant region gamma 1, aa
      104-330 encoded by nucleotides 295-990 of gi|12054071|ref|
      AJ294730.1|

<400> 41
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210> 42
<211> 222
<212> PRT
<213> Mus musculus


<220> 
<223> Mouse immunoglobulin heavy chain constant region gamma 1, aa
      103-324 encoded by nucleotides 307-975 of gi|195165|ref|
      M60435.1|

<400> 42
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
1               5                   10                  15      
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            20                  25                  30          
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        35                  40                  45              
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    50                  55                  60                  
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
65                  70                  75                  80  
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                85                  90                  95      
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        115                 120                 125             
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    130                 135                 140                 
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
145                 150                 155                 160 
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                165                 170                 175     
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            180                 185                 190         
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        195                 200                 205             
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220         

<210> 43
<211> 2328
<212> DNA
<213> Homo sapiens


<220> 
<223> Human SEMA3A-delta Ig-b

<400> 43
atgggatggc tgaccagaat cgtgtgcctg ttctggggcg tgctgctgac cgccagagcc      60

aactaccaga acggcaagaa caacgtgccc cggctgaagc tgagctacaa agagatgctg     120

gaaagcaaca acgtgatcac cttcaacggc ctggccaaca gcagcagcta ccacaccttt     180

ctgctggacg aggaacggtc ccggctgtac gtgggagcca aggaccacat cttcagcttc     240

gacctcgtga acatcaagga cttccagaaa atcgtgtggc ccgtgtccta caccagacgg     300

gacgagtgca agtgggccgg caaggacatc ctgaaagagt gcgccaactt catcaaggtg     360

ctgaaggcct acaaccagac ccacctgtac gcctgtggca ccggcgcctt ccaccctatc     420

tgcacctaca tcgagatcgg ccaccacccc gaggacaata tcttcaagct ggaaaacagc     480

cacttcgaga acggcagagg caagagcccc tacgacccca agctgctgac agcctccctg     540

ctgatcgacg gcgagctgta ctctggcaca gccgccgact tcatgggccg ggacttcgcc     600

atcttcagaa ccctgggaca ccaccaccca atccggaccg agcagcacga cagcagatgg     660

ctgaacgacc ctaagttcat cagcgcccac ctgatcagcg agagcgacaa ccctgaggac     720

gacaaggtgt acttcttctt ccgggaaaac gccatcgacg gggagcacag cggaaaggcc     780

acacacgcca gaatcggcca gatctgcaag aacgacttcg gcggccaccg gtccctcgtg     840

aacaagtgga ccaccttcct gaaggcccgg ctgatctgta gcgtgccagg ccccaatggc     900

atcgacaccc acttcgacga gctgcaggac gtgttcctga tgaatttcaa ggaccccaag     960

aaccccgtgg tgtacggcgt gttcaccacc agcagcaaca tcttcaaggg cagcgccgtg    1020

tgcatgtaca gcatgagcga cgtgcggcgg gtgttcctgg gaccttacgc ccatagagat    1080

ggccccaatt accagtgggt gccctaccag ggcagagtgc cttaccccag acctggcacc    1140

tgtcccagca agacctttgg cggcttcgac agcaccaagg acctgcccga cgatgtgatt    1200

accttcgcca gatcccaccc cgccatgtac aaccccgtgt tccccatgaa caaccggccc    1260

atcgtgatca agaccgacgt gaactaccag ttcacccaga tcgtggtgga cagagtggac    1320

gccgaggacg gccagtacga cgtgatgttc atcggcaccg acgtgggcac cgtgctgaaa    1380

gtggtgtcca tccccaaaga gacttggtac gacctggaag aggtgctgct ggaagagatg    1440

accgtgttca gagagcccac cgccatctcc gccatggaac tgagcacaaa gcagcagcag    1500

ctgtacatcg gcagcacagc tggcgtggca cagctgcctc tgcacagatg cgacatctac    1560

ggcaaggcct gcgccgagtg ttgcctggcc agagatcctt actgcgcctg ggatggcagc    1620

gcctgcagca gatacttccc caccgacaag acccacacat gccccccttg tcctgcccct    1680

gaactgctgg gaggcccctc cgtgtttctg ttccccccaa agcccaagga taccctgatg    1740

atcagcagaa cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggaccctgaa    1800

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga    1860

gaggaacagt acaacagcac ctaccgcgtg gtgtccgtgc tgaccgtgct gcaccaggac    1920

tggctgaatg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgcccccatc    1980

gagaaaacca tcagcaaggc caagggccag ccccgcgaac cccaggtgta cacactgccc    2040

cctagcaggg acgagctgac caagaaccag gtgtccctga cctgtctcgt gaagggcttc    2100

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag    2160

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtacagcaa gctgacagtg    2220

gacaagagcc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg    2280

cacaaccact acacccagaa gtccctgagc ctgagccccg gcaaatga                 2328


<210> 44
<211> 2313
<212> DNA
<213> Mus musculus


<220> 
<223> Mouse Sema3A-delta ÂIg-b

<400> 44
atgggatggt ttactggaat tgcctgtctg ttttggggag tgcttctgac tgccagagca      60

aattacgcca atggcaagaa caacgtcccc agactgaagc tctcttacaa ggagatgctg     120

gagtctaaca atgtgattac attcaatggc cttgccaact cttcctcata ccacaccttt     180

ctgctggatg aggagcgctc acggctgtat gtgggagcca aggaccatat tttcagtttt     240

aatctcgtga atatcaagga ttttcagaag atcgtatggc ctgtctcata tacccgcaga     300

gacgagtgca aatgggcagg caaagatata ctgaaggaat gcgcaaattt cattaaggtg     360

ctcgaggcat acaaccagac acacttgtat gcctgtggga ctggcgcgtt ccatcctatt     420

tgtacataca tcgaggtggg acatcatccg gaggacaaca tcttcaagtt gcaggatagc     480

cacttcgaga acggcagggg aaagtcacct tacgacccaa aactcctgac tgcttccctg     540

cttatcgacg gtgaactcta ctctggcacc gcagccgact ttatgggcag agactttgct     600

atattcagga ccctcggaca tcatcatccg attcggaccg agcaacacga ctcacgctgg     660

ctgaatgacc ccagattcat ttcagcccac ctgatccccg aaagtgataa cccagaggac     720

gacaaagtat acttcttctt tcgcgagaat gctatagacg gcgagcacag cggaaaggct     780

actcatgctc ggatcgggca aatctgtaaa aacgattttg gaggccatcg atcattggtt     840

aacaagtgga ccacatttct taaagcaaga cttatctgct ctgtgcctgg tccaaacggg     900

atagatactc atttcgacga gctgcaggac gtgttcctta tgaacagtaa ggacccgaag     960

aaccctatcg tgtacggagt ttttacgacg tcctccaaca tcttcaaggg ctcagcagtc    1020

tgcatgtata gcatgagcga cgtccggagg gtcttcctcg gaccctacgc acaccgcgat    1080

ggccccaatt atcagtgggt tccttatcaa gggagagtac cttaccctag accagggaca    1140

tgtccatcca agacattcgg aggttttgat tcaaccaagg acttgccaga cgatgtcata    1200

accttcgcca gatcacaccc cgccatgtac aatcctgttt ttccgattaa caaccgcccc    1260

attatgatca aaactgatgt gaactatcaa ttcacccaga ttgttgtaga tagagttgat    1320

gctgaggatg gccagtatga tgtcatgttc atcggtacag acgtgggaac agtcttgaaa    1380

gtcgtttctg tccctaaaga gacctggcac gacctggaag aggtcctcct ggaggagatg    1440

acagtgttcc gggagcccac cacaatcagc gccatggaac tctctaccaa gcagcagcag    1500

ctctacatcg gttccacagc tggggtggct cagcttcccc tccacagatg cgacatatac    1560

gggaaggcct gtgctgagtg ctgcctggcc agagatccct actgcgcgtg ggatggttca    1620

agttgcagtc gatacttccc cacagggtgc aagccttgta tttgtactgt gcccgaagtg    1680

tcctccgtgt tcatctttcc acccaagcct aaggacgttt tgacaataac gctgacccca    1740

aaggtgacgt gcgttgtggt cgatatcagc aaggacgatc cagaagtcca gttttcttgg    1800

tttgttgatg atgtggaagt acacactgcg caaacacagc ctagggaaga gcagtttaac    1860

tctactttta ggagcgtaag cgagctgccg attatgcatc aggactggtt gaatgggaag    1920

gagttcaaat gtcgcgttaa ctccgcagcc ttccccgcac ctatcgaaaa aacgatctca    1980

aagactaagg gtaggccaaa agcgccacag gtatacacca ttcctccacc gaaggaacag    2040

atggcaaaag ataaggtttc actgacatgc atgattactg actttttccc cgaggatatc    2100

accgtggaat ggcagtggaa tggccaaccc gcagagaact ataagaacac tcaaccaatt    2160

atggacacag acggctcata tttcgtgtac tctaagctga atgtccagaa gtcaaattgg    2220

gaagctggaa acacgtttac ctgtagtgtg ttgcatgagg gactgcacaa ccatcatacc    2280

gaaaagtcat tgtcccatag cccaggaaag tga                                 2313


<210> 45
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 527-539

<400> 45
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
1               5                   10              

<210> 46
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 526-538

<400> 46
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
1               5                   10              

<210> 47
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 524-536

<400> 47
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
1               5                   10              

<210> 48
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 544-556

<400> 48
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
1               5                   10              

<210> 49
<211> 202
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 96-297

<400> 49
Ser Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu 
1               5                   10                  15      
Lys Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr 
            20                  25                  30          
His Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr 
        35                  40                  45              
Ile Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn 
    50                  55                  60                  
Ser His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu 
65                  70                  75                  80  
Leu Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala 
                85                  90                  95      
Ala Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His 
            100                 105                 110         
His His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp 
        115                 120                 125             
Pro Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu 
    130                 135                 140                 
Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu 
145                 150                 155                 160 
His Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn 
                165                 170                 175     
Asp Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu 
            180                 185                 190         
Lys Ala Arg Leu Ile Cys Ser Val Pro Gly 
        195                 200         

<210> 50
<211> 203
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 95-297

<400> 50
Pro Val Glu Trp Arg Glu Glu Cys Asn Trp Lys Gly Lys Asp Ile Gly 
1               5                   10                  15      
Thr Glu Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr 
            20                  25                  30          
His Leu Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe 
        35                  40                  45              
Val Glu Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro 
    50                  55                  60                  
Gly Arg Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His 
65                  70                  75                  80  
Arg Ala Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala 
                85                  90                  95      
Ala Asp Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln 
            100                 105                 110         
Arg Pro Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu 
        115                 120                 125             
Pro Lys Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp 
    130                 135                 140                 
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala 
145                 150                 155                 160 
Pro Ala Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg 
                165                 170                 175     
Asn Asp Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe 
            180                 185                 190         
Leu Lys Ala Arg Leu Val Cys Ser Val Pro Gly 
        195                 200             

<210> 51
<211> 201
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 94-294

<400> 51
Ser Thr Ile Lys Val Glu Glu Cys Lys Met Lys Gly Lys Asp Pro Thr 
1               5                   10                  15      
His Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr 
            20                  25                  30          
His Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr 
        35                  40                  45              
Leu Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser 
    50                  55                  60                  
Lys Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn 
65                  70                  75                  80  
Thr Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile 
                85                  90                  95      
Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg 
            100                 105                 110         
Asn Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro 
        115                 120                 125             
Met Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp 
    130                 135                 140                 
Ala Lys Val Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg 
145                 150                 155                 160 
Ser Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp 
                165                 170                 175     
Thr Gly Gly Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
            180                 185                 190         
Ala Arg Leu Val Cys Ser Val Thr Asp 
        195                 200     

<210> 52
<211> 205
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 110-314

<400> 52
Ala Lys Glu Arg Val Glu Leu Cys Lys Leu Lys Gly Lys Asp Ala Asn 
1               5                   10                  15      
Thr Glu Cys Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr 
            20                  25                  30          
His Ile Tyr Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr 
        35                  40                  45              
Ile Asp Leu Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr 
    50                  55                  60                  
His Asn Leu Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln 
65                  70                  75                  80  
Pro Phe Ala Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala 
                85                  90                  95      
Ser Asp Phe Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro 
            100                 105                 110         
Thr His Asp His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp 
        115                 120                 125             
Leu Asn Gly Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr 
    130                 135                 140                 
Asn Pro Asp Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln 
145                 150                 155                 160 
Glu Gly Ser Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val 
                165                 170                 175     
Cys Lys Asn Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr 
            180                 185                 190         
Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly 
        195                 200                 205 

<210> 53
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3A: 104-113

<400> 53
Lys Trp Lys Gly Lys Asp Ile Leu Lys Glu 
1               5                   10  

<210> 54
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B: 103-112

<400> 54
Asn Trp Lys Gly Lys Asp Ile Gly Thr Glu 
1               5                   10  

<210> 55
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C: 102-111

<400> 55
Lys Met Lys Gly Lys Asp Pro Thr His Gly 
1               5                   10  

<210> 56
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D: 118-127

<400> 56
Lys Leu Lys Gly Lys Asp Ala Asn Thr Glu 
1               5                   10  

<210> 57
<211> 5672
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length human SEMA3A A106K

<220> 
<221> CDS
<222> 316..2631
<223> /transl_table=1

<400> 57
aagcaccact gcagcagacc ttgttaattt tttttttttt tctttccaca caacagttgt    60

gcctcattat ccggtgcctg gctcggaatt tttttttttt tttttctttt tggagggttt   120

gaagtttctg tgcttcagtg actgttacag aagaagaggt gttagtgttg ccatgaggtc   180

ttgattgtct gcatttatga atgaaactga cctaaatcac ctgttacctc cagtttccag   240

attgtttgaa cttctctggc cgcacaatac aggaaggaag actaaagcag caaagggacc   300

tacagcgtct gcagc atg ggc tgg tta act agg att gtc tgt ctt ttc tgg    351
                 Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp 
                 1               5                   10          

gga gta tta ctt aca gca aga gca aac tat cag aat ggg aag aac aat     399
Gly Val Leu Leu Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn 
        15                  20                  25              

gtg cca agg ctg aaa tta tcc tac aaa gaa atg ttg gaa tcc aac aat     447
Val Pro Arg Leu Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn 
    30                  35                  40                  

gtg atc act ttc aat ggc ttg gcc aac agc tcc agt tat cat acc ttc     495
Val Ile Thr Phe Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe 
45                  50                  55                  60  

ctt ttg gat gag gaa cgg agt agg ctg tat gtt gga gca aag gat cac     543
Leu Leu Asp Glu Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His 
                65                  70                  75      

ata ttt tca ttc gac ctg gtt aat atc aag gat ttt caa aag att gtg     591
Ile Phe Ser Phe Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val 
            80                  85                  90          

tgg cca gta tct tac acc aga aga gat gaa tgc aag tgg aag gga aaa     639
Trp Pro Val Ser Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys 
        95                  100                 105             

gac atc ctg aaa gaa tgt gct aat ttc atc aag gta ctt aag gca tat     687
Asp Ile Leu Lys Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr 
    110                 115                 120                 

aat cag act cac ttg tac gcc tgt gga acg ggg gct ttt cat cca att     735
Asn Gln Thr His Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile 
125                 130                 135                 140 

tgc acc tac att gaa att gga cat cat cct gag gac aat att ttt aag     783
Cys Thr Tyr Ile Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys 
                145                 150                 155     

ctg gag aac tca cat ttt gaa aac ggc cgt ggg aag agt cca tat gac     831
Leu Glu Asn Ser His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp 
            160                 165                 170         

cct aag ctg ctg aca gca tcc ctt tta ata gat gga gaa tta tac tct     879
Pro Lys Leu Leu Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser 
        175                 180                 185             

gga act gca gct gat ttt atg ggg cga gac ttt gct atc ttc cga act     927
Gly Thr Ala Ala Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr 
    190                 195                 200                 

ctt ggg cac cac cac cca atc agg aca gag cag cat gat tcc agg tgg     975
Leu Gly His His His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp 
205                 210                 215                 220 

ctc aat gat cca aag ttc att agt gcc cac ctc atc tca gag agt gac    1023
Leu Asn Asp Pro Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp 
                225                 230                 235     

aat cct gaa gat gac aaa gta tac ttt ttc ttc cgt gaa aat gca ata    1071
Asn Pro Glu Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile 
            240                 245                 250         

gat gga gaa cac tct gga aaa gct act cac gct aga ata ggt cag ata    1119
Asp Gly Glu His Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile 
        255                 260                 265             

tgc aag aat gac ttt gga ggg cac aga agt ctg gtg aat aaa tgg aca    1167
Cys Lys Asn Asp Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr 
    270                 275                 280                 

aca ttc ctc aaa gct cgt ctg att tgc tca gtg cca ggt cca aat ggc    1215
Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly 
285                 290                 295                 300 

att gac act cat ttt gat gaa ctg cag gat gta ttc cta atg aac ttt    1263
Ile Asp Thr His Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe 
                305                 310                 315     

aaa gat cct aaa aat cca gtt gta tat gga gtg ttt acg act tcc agt    1311
Lys Asp Pro Lys Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser 
            320                 325                 330         

aac att ttc aag gga tca gcc gtg tgt atg tat agc atg agt gat gtg    1359
Asn Ile Phe Lys Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val 
        335                 340                 345             

aga agg gtg ttc ctt ggt cca tat gcc cac agg gat gga ccc aac tat    1407
Arg Arg Val Phe Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr 
    350                 355                 360                 

caa tgg gtg cct tat caa gga aga gtc ccc tat cca cgg cca gga act    1455
Gln Trp Val Pro Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr 
365                 370                 375                 380 

tgt ccc agc aaa aca ttt ggt ggt ttt gac tct aca aag gac ctt cct    1503
Cys Pro Ser Lys Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro 
                385                 390                 395     

gat gat gtt ata acc ttt gca aga agt cat cca gcc atg tac aat cca    1551
Asp Asp Val Ile Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro 
            400                 405                 410         

gtg ttt cct atg aac aat cgc cca ata gtg atc aaa acg gat gta aat    1599
Val Phe Pro Met Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn 
        415                 420                 425             

tat caa ttt aca caa att gtc gta gac cga gtg gat gca gaa gat gga    1647
Tyr Gln Phe Thr Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly 
    430                 435                 440                 

cag tat gat gtt atg ttt atc gga aca gat gtt ggg acc gtt ctt aaa    1695
Gln Tyr Asp Val Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys 
445                 450                 455                 460 

gta gtt tca att cct aag gag act tgg tat gat tta gaa gag gtt ctg    1743
Val Val Ser Ile Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu 
                465                 470                 475     

ctg gaa gaa atg aca gtt ttt cgg gaa ccg act gct att tca gca atg    1791
Leu Glu Glu Met Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met 
            480                 485                 490         

gag ctt tcc act aag cag caa caa cta tat att ggt tca acg gct ggg    1839
Glu Leu Ser Thr Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly 
        495                 500                 505             

gtt gcc cag ctc cct tta cac cgg tgt gat att tac ggg aaa gcg tgt    1887
Val Ala Gln Leu Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys 
    510                 515                 520                 

gct gag tgt tgc ctc gcc cga gac cct tac tgt gct tgg gat ggt tct    1935
Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser 
525                 530                 535                 540 

gca tgt tct cgc tat ttt ccc act gca aag aga cgc aca aga cga caa    1983
Ala Cys Ser Arg Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln 
                545                 550                 555     

gat ata aga aat gga gac cca ctg act cac tgt tca gac tta cac cat    2031
Asp Ile Arg Asn Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His 
            560                 565                 570         

gat aat cac cat ggc cac agc cct gaa gag aga atc atc tat ggt gta    2079
Asp Asn His His Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val 
        575                 580                 585             

gag aat agt agc aca ttt ttg gaa tgc agt ccg aag tcg cag aga gcg    2127
Glu Asn Ser Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala 
    590                 595                 600                 

ctg gtc tat tgg caa ttc cag agg cga aat gaa gag cga aaa gaa gag    2175
Leu Val Tyr Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu 
605                 610                 615                 620 

atc aga gtg gat gat cat atc atc agg aca gat caa ggc ctt ctg cta    2223
Ile Arg Val Asp Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu 
                625                 630                 635     

cgt agt cta caa cag aag gat tca ggc aat tac ctc tgc cat gcg gtg    2271
Arg Ser Leu Gln Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val 
            640                 645                 650         

gaa cat ggg ttc ata caa act ctt ctt aag gta acc ctg gaa gtc att    2319
Glu His Gly Phe Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile 
        655                 660                 665             

gac aca gag cat ttg gaa gaa ctt ctt cat aaa gat gat gat gga gat    2367
Asp Thr Glu His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp 
    670                 675                 680                 

ggc tct aag acc aaa gaa atg tcc aat agc atg aca cct agc cag aag    2415
Gly Ser Lys Thr Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys 
685                 690                 695                 700 

gtc tgg tac aga gac ttc atg cag ctc atc aac cac ccc aat ctc aac    2463
Val Trp Tyr Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn 
                705                 710                 715     

aca atg gat gag ttc tgt gaa caa gtt tgg aaa agg gac cga aaa caa    2511
Thr Met Asp Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln 
            720                 725                 730         

cgt cgg caa agg cca gga cat acc cca ggg aac agt aac aaa tgg aag    2559
Arg Arg Gln Arg Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys 
        735                 740                 745             

cac tta caa gaa aat aag aaa ggt aga aac agg agg acc cac gaa ttt    2607
His Leu Gln Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe 
    750                 755                 760                 

gag agg gca ccc agg agt gtc tga gctgcattac ctctagaaac ctcaaacaag   2661
Glu Arg Ala Pro Arg Ser Val                                      
765                 770                                          

tagaaacttg cctagacaat aactggaaaa acaaatgcaa tatacatgaa cttttttcat  2721

ggcattatgt ggatgtttac aatggtggga aattcagctg agttccacca attataaatt  2781

aaatccatga gtaactttcc taataggctt tttttcctaa taccaccacc taacagagaa  2841

cacaggtgaa tgcagatgtt cactttagca gacttaatgt ttcctatgag atttcactgt  2901

acaggtttgt ctttcttctt tgcctgagaa ataaaaatgt catttgccat attgccatct  2961

aaaggagaaa aactgcatca gcaaagccat tgtattgaac taaaagttta aaatgaactg  3021

catggattta ctaagctgat gaatattcca aaacgtggtt ggattcaagg atatattttg  3081

tctaccggcc ctcatgtttg tatgtacttg aggagtaaaa tgagtaaaat gatactgaat  3141

gaaatgttct gtggaaatat taaaaaaaaa aaaaaacata agccatccat catccagaag  3201

aaaaatggaa tacactgatc tactactgat gtcttctttc agctttgatc taaagatgta  3261

ttttattaaa actataattt aaatgtacca tgaaaaatat gcagtaaaaa ttagttgttt  3321

tctaagctag agtaggattt gtcttacaat tattgtgcta tgtagttttt gttttaaaaa  3381

ttccaatggt gtgctgcttt ctttggacat tttattttca attctataag agggatagat  3441

gacattgttc tagaaacaca tatacatcat taagagtgaa tctctaaaac caggatataa  3501

attatgcttt atttctctga gaaaatcaaa caaatggaag ctgttcacac ctccccttct  3561

ttaagcatta tctaaattaa tttttacttg cataatgttc ttagaaaaaa aaacagaaca  3621

tttaagcagg aaaaaaggaa gaaacaagtt gatttttaag tgcattttac tataatgaat  3681

caatgaaggg aaaaggaact gcatatttca tgaaaataat aagcattgtc ttaatatact  3741

gttaatagaa aatgtgtctt aattccgtgc ttgaatccct gcatgatatt tgagactaag  3801

atctctctta tgattctacc aagaattata tctgtgtcac ttaatttttt taaaagagag  3861

agatcaataa ctattcagag caacatgtta aaggcaaagt ttccaatcat ttacatctgt  3921

atcaggtgcc tcttaccttt ccttatttaa gacaattatt tgtacaagaa acacatgact  3981

cttttcatat caatgggagg gacttttcta caaagtattt tccaggatgc aacccacatt  4041

taaacaatgt aaaattcttt gtttcctgca acaacttaca aaataaggta aaagactaaa  4101

attcaagatt tgcttccttc attgtcctaa gacgattcgt tgagaatcac tgactttgag  4161

atatttaaaa ctttcagcat tatactgtgg tttcttttgc actgcactca cctattcagg  4221

actcctcccc caggttcctc atcatgcaca aaaatgcaaa gaaaacatct tattagtaat  4281

taatgaagca acattgaaat tctaactcta gctgtctttg gattctaatt aactcagcat  4341

caatttctca cctcagacta cagtgaattt ttatttccta tcagctgaaa tatttcacag  4401

atggaagctc atgtttcagt tttaatgact gccttgaata aacaagttgt tgccacttgt  4461

ttcaaacaaa agcctaaaaa taatctacat tcaattttag gctccattga ctaatatggt  4521

gttgcttttg gaagtactgt atatcctcac atggaagcca aattgttaaa ttatttgaag  4581

gacacaccac tgtacagaaa gtagtgtttc aaatataaat cgaagaacaa agagtgctcc  4641

aaaaaatagg tcattctttt attttcataa agtatctaaa ctgtactaac attcagtgtt  4701

gtgtttcatt ctaaatttgc agctgaaata aatttatttg cgatagcaga aatatcttat  4761

tattcatcct cagaaataaa ggatttgaag ggatagagat tatatgataa atttatagaa  4821

gactttcaga atttgaatgc attttgttta gtgttatgaa atgacaatag aaaaaagtct  4881

cgacttcaat taaaagttac acaaacaaac aaatctacag gcatgtcttt atataccatc  4941

aggtctaagt tttcaaagaa aattgtagat ataacttgca gataactcat tacagtcata  5001

atctctgccc atgtgtattg agagggggca gtttgcacga aaaagaatta ttggcccatt  5061

taataattca gctttaaata gactttgtca tatgcatgaa tcatcagaga tgaaactgtt  5121

tgagagactc atgtgacctt acgaaaatta caacagcagt cttaaagtat gaaaaagatg  5181

catcacagca gagacattat ggcccagttg atatcaaatg taaaatgtaa atgcatgtaa  5241

atgcacactt cattttatgt attatttagt aatttgcagt ggtatgtgtt taatattttt  5301

gctacctaca cattaggcaa aaaaaagatg taaataattt gggagaaaaa gaggaagaac  5361

agtgtaaaat aaaactttct ataagtactc catttcaatg tgttcaacat catcctaaaa  5421

ggcaagattt tcccacgcag gtgacaaggt ggtttatgta ctatttaagg gcggaaggtg  5481

cgtgcccgtt caataagcat gttttttgcc aggtaggaaa tatgttccat atctttactt  5541

atcattgcat ttcagatggg aactagaaaa actggagaga aaaatgtaat gaaactgctg  5601

ctgtaaatta ttccttttag catgtattca cttgctaaat acacatttct tcaaaataaa  5661

aaaaaaaaaa a                                                       5672

<210> 58
<211> 771
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:316..2631 from SEQ ID NO 57

<400> 58
Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     
Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 
Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 
Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     
Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         
Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             
Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 
Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 
Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     
Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         
Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             
Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 
Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 
Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     
Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         
Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             
Arg Ser Val 
    770     

<210> 59
<211> 6850
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length mouse Sema3A A106K, transcript variant 1

<220> 
<221> CDS
<222> 650..2968
<223> /transl_table=1

<400> 59
gtgacaagag ggaaggggag tgggttgagc tcgctcctct cccattgtca gcgcgtctag    60

tgagtgttgg gaaaacctgt ccgcgggatc ctgtgtcatc tctccctgct tgtgcacagg   120

aaaagtccgc gctgctctgc tcacggctgc tcgcaccccc tctctctcct ctctctcttt   180

ctctgtttcc ctttcattct gcttcctcgg agccgaatga agcagggaga gggagcagga   240

ttagagtcag ccaccggcta tcagcggagc ggagataaaa ggaactgctt cttaagcgcc   300

actgccgcag cccttgttaa tttttttctt cttcttcttc ttctttccac acaacagttg   360

tgcctcatta tccggtgcct ggctcgattt ttttctttct tttttctttt tttcttttct   420

ttcttccttt tttttttttt tctttttttg agggtttgaa gtttctgtga ttccgtgact   480

gttacagaag agacgttagt gttgccatga ggtcttgatt gtctgcattt atgaatgaaa   540

ctgacctaaa tcacctgtta cctccagttt ccagattgtt tgaacttctc tggccgcaca   600

atacaggaag gaaggctgcc gcagctcagg gacctccagc gtctgcagc atg ggc tgg   658
                                                      Met Gly Trp 
                                                      1           

ttc act ggg att gcc tgt ctt ttc tgg ggt gta tta ctt aca gcc aga     706
Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu Thr Ala Arg 
    5                   10                  15                  

gca aac tat gca aac gga aag aac aat gtg cca aga ctg aaa tta tcg     754
Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser 
20                  25                  30                  35  

tac aaa gaa atg ttg gaa tcc aac aat gtg atc act ttt aat ggc ttg     802
Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu 
                40                  45                  50      

gcc aac agc tcc agt tac cac acc ttc ctt ctg gat gaa gaa cgg agt     850
Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser 
            55                  60                  65          

aga cta tat gtt gga gca aaa gat cat ata ttt tca ttc aac ttg gtg     898
Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val 
        70                  75                  80              

aac att aaa gat ttt caa aag att gtg tgg cca gta tct tac aca agg     946
Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg 
    85                  90                  95                  

aga gat gaa tgc aaa tgg aag gga aaa gat atc ctg aaa gaa tgt gcc     994
Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys Glu Cys Ala 
100                 105                 110                 115 

aat ttc atc aag gtc ctg gag gct tat aat cag act cac ttg tat gcc    1042
Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His Leu Tyr Ala 
                120                 125                 130     

tgt gga act ggg gct ttc cat cca atc tgc acc tat att gaa gtt gga    1090
Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly 
            135                 140                 145         

cat cat cct gag gac aac att ttt aag ctg cag gac tca cat ttt gaa    1138
His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu 
        150                 155                 160             

aac ggt cgt ggg aag agc cct tat gat ccc aaa cta ctg act gcc tct    1186
Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser 
    165                 170                 175                 

ctt cta ata gac ggt gag ttg tac tct gga act gct gcg gac ttc atg    1234
Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met 
180                 185                 190                 195 

gga cgg gac ttc gct atc ttc aga aca ctg ggg cac cat cac ccc atc    1282
Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile 
                200                 205                 210     

agg acg gag cag cat gac tcc cgg tgg ctc aat gat cct aga ttc atc    1330
Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile 
            215                 220                 225         

agt gcc cat ctc atc cca gag agt gac aac cct gaa gat gac aaa gta    1378
Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val 
        230                 235                 240             

tat ttt ttc ttc cga gaa aat gca ata gac gga gaa cac tct gga aaa    1426
Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys 
    245                 250                 255                 

gcc act cat gct aga ata ggt cag ata tgc aag aat gac ttt ggt gga    1474
Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly 
260                 265                 270                 275 

cac aga agt ctt gtg aat aaa tgg aca aca ttc cta aaa gca cgc ctg    1522
His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
                280                 285                 290     

att tgc tct gtg ccc ggt ccc aat ggc att gac acc cat ttt gat gaa    1570
Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu 
            295                 300                 305         

ttg cag gat gta ttc cta atg aac tct aaa gat cct aaa aat ccg atc    1618
Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile 
        310                 315                 320             

gtc tat gga gtg ttc aca aca tca agc aac atc ttt aag gga tct gct    1666
Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala 
    325                 330                 335                 

gtg tgc atg tac agc atg agt gat gta aga agg gtg ttc ctt ggt cca    1714
Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro 
340                 345                 350                 355 

tat gct cac aga gat ggt ccc aac tat cag tgg gtg cct tac caa gga    1762
Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly 
                360                 365                 370     

aga gtc cct tat cca cgg cca gga act tgt ccc agt aaa aca ttt ggc    1810
Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly 
            375                 380                 385         

gga ttt gac tcc aca aag gac ctt cct gat gat gtc ata act ttt gca    1858
Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala 
        390                 395                 400             

aga agt cat cca gcc atg tac aac cca gtg ttt cct ata aat aat cgc    1906
Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg 
    405                 410                 415                 

ccg atc atg atc aaa aca gat gta aat tat cag ttc aca caa att gtt    1954
Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val 
420                 425                 430                 435 

gta gac cga gtg gat gca gaa gat ggc cag tat gat gtt atg ttc atc    2002
Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile 
                440                 445                 450     

gga aca gat gtt gga acc gtt ctt aaa gtg gtt tca gtc ccc aag gag    2050
Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu 
            455                 460                 465         

act tgg cat gac cta gaa gaa gtt ctt ctg gaa gaa atg acc gtc ttc    2098
Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe 
        470                 475                 480             

cgg gaa cca aca act att tcg gca atg gag ctt tct act aaa cag caa    2146
Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln 
    485                 490                 495                 

cag ctg tac att ggc tca act gcg gga gtg gca cag ctt cct cta cac    2194
Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His 
500                 505                 510                 515 

cgc tgt gac atc tat ggc aaa gcc tgt gca gaa tgc tgc ctc gct cgg    2242
Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg 
                520                 525                 530     

gac cct tac tgt gcc tgg gat ggg tcc tca tgc tca cgc tat ttt cct    2290
Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro 
            535                 540                 545         

act gca aag agg cgc aca aga cga caa gat ata agg aat gga gac cca    2338
Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro 
        550                 555                 560             

ctg act cac tgc tct gac ttg cag cac cat gat aat cat cat ggg ccc    2386
Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His His Gly Pro 
    565                 570                 575                 

agc ctt gaa gag aga atc atc tat gga gtg gaa aac agt agt aca ttc    2434
Ser Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe 
580                 585                 590                 595 

ttg gaa tgc agt ccg aag tca cag aga gcc ttg gta tat tgg caa ttt    2482
Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe 
                600                 605                 610     

cag agg aga aat gaa gat cga aaa gag gag atc aga atg ggt gat cat    2530
Gln Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Met Gly Asp His 
            615                 620                 625         

atc atc agg aca gaa caa ggg ctc ctg ctc cgt agc ctg cag aag aag    2578
Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu Gln Lys Lys 
        630                 635                 640             

gat tca ggc aat tac ctg tgt cac gct gtg gaa cac gga ttc atg caa    2626
Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Met Gln 
    645                 650                 655                 

act ctt ctt aag gta acc ctg gaa gtc att gac aca gaa cat ttg gaa    2674
Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu 
660                 665                 670                 675 

gaa ctt ctt cat aaa gat gac gat gga gat ggc tct aag ata aaa gaa    2722
Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Ile Lys Glu 
                680                 685                 690     

atg tcg agc agc atg acg ccc agc cag aaa gtc tgg tac cga gac ttc    2770
Met Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe 
            695                 700                 705         

atg cag ctc att aac cac ccc aac ctg aac acg atg gat gag ttc tgt    2818
Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys 
        710                 715                 720             

gaa caa gtg tgg aaa agg gac cga aag caa cgc cga caa agg ccg ggg    2866
Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly 
    725                 730                 735                 

cac tct caa ggg agc agc aac aag tgg aag cac atg caa gag agc aag    2914
His Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln Glu Ser Lys 
740                 745                 750                 755 

aaa ggt aga aac agg agg acc cac gag ttt gag cgg gca ccc aga agt    2962
Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser 
                760                 765                 770     

gtc tga gctgcgccac ctcccaaaac ctcaaacaag tacaaacttg cttagataat     3018
Val                                                            
                                                               

aactggaaaa aatgcaatac acatgaacat ttcatggcat tatgtggatg tttacaatga  3078

tgggaagttc aaccgggttc caccaattta agtccgtgag gaactttccc agcaggcttt  3138

cttcagtata ccaacgcttg acagagatca caggtgagca tagatgttca cgtccgctga  3198

cttagtgttt cctctgaaag ttcattttgc ttccttcttt gcctgagaaa taaaaatgtc  3258

atttgccatc gaaaggagaa aaactgcatc agcaaagcca ttttattgaa gcaagagttg  3318

aaaataaact gcatggattt agtaagcaga tgaatattcc aaaacgtgat tggattcaag  3378

gatgttttgt ctaccagcac tcgtgtttgt atgtactgga gaagtaaaat aaggagaatg  3438

acactgagtg aaatagtcta tggagatata aaaacacaaa ccacccatca tccagagtaa  3498

tggagtacat tgatctacta ctgatgtctt ctttcagctt tgatctaaag atgtatttta  3558

ttaaagttat aatttaaatg taccatggca aatatgcagt aaagattagc tgtttcctaa  3618

gctagagtag gtcttgtctt gcagttacca tgctatatcg tttgtttaaa aattccaact  3678

gtgtgctgct tttttacatt gtgttttcag ttctgtaaga ggcagtatat cactttaggt  3738

ccctactcac tgtactatta cttactgaca ccaagaatta tggtcttccc ctttgaagaa  3798

accaaacaga tagaaggtta tcaccctgac ttgcaaaggt attatctaag ttaactctca  3858

catacataat gttttcagtc aaccaaaaat taagacagca caaagagaag aaaacagtca  3918

ttagaggcat cctgaaggat caagagcaaa attaaattca tgtgtctcat gaaaagaaca  3978

ttgtcttaac agagtgttga taaaatgtct ttccctcttg gcttgaatat ttgcatgatg  4038

tgtgaggcat aggactcgct catgattcca catcccacca aagattctat tttcagtcac  4098

ttaatgattt ccaaagcaga gagaaagagc gggggtgggg ggaatcagtg acattcagga  4158

catgttctaa caacaaaatg acacatttct caactatttc tttgtgaatc aactaaattt  4218

tacccaccct gtatgataca attatttgtc tgaacaactt ataagtgttt tatctcaatg  4278

agagtgaaac tatacacttc acctagaaag tgcaaaattc tttgttttat gaataaaata  4338

taagataaca caaaatgttt cagaatgtat agcctttgtt ggttggagat gatttcctaa  4398

gaatcattga gttcaaaatg cttaataaat tcaacattat agaccagttc attggtgcta  4458

caggcctcac ttcaggaatt tttttcttcg atccttcagc atgcacaaaa atgcaaagta  4518

aatatcttct tgctaagaaa tgaagtggcg ttgatatttt aactccagtt gtctcctaat  4578

tctaattaac tcagtattaa cttctcacct caactacacc aaattgtcat tccctcgcca  4638

ctgaaatagt tcacagatgg aagcttctgt ttcagtttta atgattattt aaataaaaaa  4698

acaatttgtt gacatgtctt tcatataaaa gcctaaaatc atcctacatc tgattttagg  4758

ctcattgact aatggtgttg cttttggaaa tatgtcttca aaggcaagct gaatggatga  4818

attatttgag atcacactct gaacagaaaa tattgtcagg aacattaagt gagagaaaga  4878

gggatgctcc aaataagcca ttctctcatt taatagggtc ttaactgtcc aaacatttaa  4938

tgttatattt cattctaaat ttgcatctga tacaagtata ttggcaatta cataactctc  4998

ccatttcttt ctagctctta acaataaagg atctaatgga aggaaggttg tttaataact  5058

ttatggatgc ctttcaaaat cggaatgcat tttgtttagc actaagaaat agcaatagaa  5118

aactgcttag gtttcaatta aaagtgttaa aaacaagcaa atatattaac atgtctcaat  5178

caatcaccat gtctaagttt caaagaaagt tattgattaa ctagggaata aataaataaa  5238

tacacacata catacataaa tcttatgaca gttataacct cccattgtgt attgagagag  5298

gacagtttgc acgaagaaga atgtcccatt tactaagtaa tttagatgga ctttggcata  5358

tgcatgtatc atcacaggta agacctgcct aagagatgca tgtgacctta agcaaattac  5418

cacagcagtc tcacaatagt ctcaagttga aaaagataca tcacagtgga gagagcaggc  5478

cccgctgata gcaactgtaa agtgtaaatg catgcaaatg cacacttatt gcttctttta  5538

tgtataattt agtgatttat aatggtatgt gtttaatatt tttgctacct acacattaga  5598

caaaggtgta aataattttg aaaagagtag aaagagcact gtaaattaca agtttctata  5658

gatgctccat tccagtttgt tcaccatcat cctcaagtgc aagatttccc atacaagtga  5718

tgcggtggct tatgtactac ttaagggcag agagggtgtg cccctcgaag agcatgcttt  5778

ttgccaggtc gtaaattgtt ccgtatctgt atttatcatt gcatttcaga tgggaactag  5838

aaaactggag agaaaaatgt aacgatattg ctgctgtaaa ttattccttt ttagcatgta  5898

ttcagttgct aaatacacat ttcttcaaaa tatttgaatt cagatgtctt tactgttcca  5958

tataacatat ggtattgagg aagataagct tcgaagcctt cgagaaccag agtcaggaat  6018

cagcataatt agctaacaga tttcttcatt gtagtattct gtaaactgtg ttctatattt  6078

atagtgatga tgtgaatttt ttgcccttta aactaaatgc tgttctcttt atgtcatacc  6138

tggaaagaac acatggatga aagtctttaa tcagtggatt atgatgtgaa gcatcataat  6198

tcaagatcaa taccgattcc agatgattgg catctagagg cctgtcctgc agctcatggg  6258

caagcactgc attaatatgg atttatttct gtaatgtgtt caagtccttc tcttataaat  6318

actattttaa acacatattt aattcactga aagtctgtca gagtttattt gcttcaaaga  6378

cacatttgac aaacaggtct tagcactatt atatactaac atgatggtta caaactggcc  6438

tggtgccaaa gaatccaaag cttttaattt taacttggta ataattattt aagtcaatgt  6498

taatatttac agtatatctt tccttaaaga agcaaacatt attttcaaaa gtatggaaat  6558

tctattagct ttattttaaa aactttccta tactagctaa ttcaaaaatc acacatttgt  6618

atattaatag ataaagacaa acccaaagtg aaagttgccc cagaaatggg ttttcttata  6678

actggtcaac tttcttgatt aacctaacca aagaaaaatc ttatttcttc atttccaaca  6738

cccaagtgca caaacacagt ctatggtaga aataaaacca aattaataaa agaggaatga  6798

ttttaagtta tgatattagg acccagacgt gacagcatca acctacaatt cc          6850

<210> 60
<211> 772
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:650..2968 from SEQ ID NO 59

<400> 60
Met Gly Trp Phe Thr Gly Ile Ala Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      
Thr Ala Arg Ala Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          
Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              
Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  
Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  
Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      
Tyr Thr Arg Arg Asp Glu Cys Lys Trp Lys Gly Lys Asp Ile Leu Lys 
            100                 105                 110         
Glu Cys Ala Asn Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His 
        115                 120                 125             
Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 
Glu Val Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser 
145                 150                 155                 160 
His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     
Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         
Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             
His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 
Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     
Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         
Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 
Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     
Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         
Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             
Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 
Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 
Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     
Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         
Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             
Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val 
    450                 455                 460                 
Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 
Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     
Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         
Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 
Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 
Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His 
                565                 570                 575     
His Gly Pro Ser Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         
Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr 
        595                 600                 605             
Trp Gln Phe Gln Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Met 
    610                 615                 620                 
Gly Asp His Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 
Gln Lys Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly 
                645                 650                 655     
Phe Met Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu 
            660                 665                 670         
His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys 
        675                 680                 685             
Ile Lys Glu Met Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr 
    690                 695                 700                 
Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 
Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     
Arg Pro Gly His Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln 
            740                 745                 750         
Glu Ser Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             
Pro Arg Ser Val 
    770         

<210> 61
<211> 2981
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length human SEMA3B A105K, transcript variant 3

<220> 
<221> CDS
<222> 247..2496
<223> /transl_table=1

<400> 61
gcgtgggtgt gtctgtgatt gtggccaggc ggggcaccct cggaggggag ggttcggaag    60

tggaatgcga ccccccagcc tctttcccct aggggctgta atctgatccc tggggactcc   120

ccccctagcc tcccgccctc gccctcactg ctgactcctc ttccagatcc tggggcagag   180

tccagggcag ctcaaggctc ctccacacac acacccgctg aaccctgagc accctgagct   240

gctgag atg ggg cgg gcc ggg gct gcc gcc gtg atc ccg ggc ctg gcc      288
       Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala 
       1               5                   10                  

ctg ctc tgg gca gtg ggg ctg ggg agt gcc gcc ccc agc ccc cca cgc     336
Leu Leu Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg 
15                  20                  25                  30  

ctt cgg ctc tcc ttc caa gag ctc cag gcc tgg cat ggt ctc cag act     384
Leu Arg Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr 
                35                  40                  45      

ttc agc ctg gag cga acc tgc tgc tac cag gcc ttg ctg gtg gat gag     432
Phe Ser Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu 
            50                  55                  60          

gag cgt gga cgc ctg ttt gtg ggt gcc gag aac cat gtg gcc tcc ctc     480
Glu Arg Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu 
        65                  70                  75              

aac ctg gac aac atc agc aag cgg gcc aag aag ctg gcc tgg ccg gcc     528
Asn Leu Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala 
    80                  85                  90                  

cct gtg gaa tgg cga gag gag tgc aac tgg aag ggg aag gac att ggt     576
Pro Val Glu Trp Arg Glu Glu Cys Asn Trp Lys Gly Lys Asp Ile Gly 
95                  100                 105                 110 

act gag tgc atg aac ttc gtg aag ttg ctg cat gcc tac aac cgc acc     624
Thr Glu Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr 
                115                 120                 125     

cat ttg ctg gcc tgt ggc acg gga gcc ttc cac cca acc tgt gcc ttt     672
His Leu Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe 
            130                 135                 140         

gtg gaa gtg ggc cac cgg gca gag gag ccc gtc ctc cgg ctg gac cca     720
Val Glu Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro 
        145                 150                 155             

gga agg ata gag gat ggc aag ggg aag agt cct tat gac ccc agg cat     768
Gly Arg Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His 
    160                 165                 170                 

cgg gct gcc tcc gtg ctg gtg ggg gag gag cta tac tca ggg gtg gca     816
Arg Ala Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala 
175                 180                 185                 190 

gca gac ctc atg gga cga gac ttt acc atc ttt cgc agc cta ggg caa     864
Ala Asp Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln 
                195                 200                 205     

cgt cca agt ctc cga aca gag cca cac gac tcc cgc tgg ctc aat gag     912
Arg Pro Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu 
            210                 215                 220         

ccc aag ttt gtc aag gta ttt tgg atc ccg gag agc gag aac cca gac     960
Pro Lys Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp 
        225                 230                 235             

gac gac aaa atc tac ttc ttc ttt cgt gag acg gcg gta gag gcg gcg    1008
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala 
    240                 245                 250                 

ccg gca ctg gga cgc ctg tcc gtg tcc cgc gtt ggc cag atc tgc cgg    1056
Pro Ala Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg 
255                 260                 265                 270 

aac gac gtg ggc ggc cag cgc agc ctg gtc aac aag tgg acg acg ttc    1104
Asn Asp Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe 
                275                 280                 285     

ctg aag gcg cgg ctg gtg tgc tcg gtg ccc ggc gtc gag ggc gac acc    1152
Leu Lys Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr 
            290                 295                 300         

cac ttc gat cag ctc cag gat gtg ttt ctg ttg tcc tcg cgg gac cac    1200
His Phe Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His 
        305                 310                 315             

cgg acc ccg ctg ctc tat gcc gtc ttc tcc acg tcc agc agc atc ttc    1248
Arg Thr Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe 
    320                 325                 330                 

cag ggc tct gcg gtg tgc gtg tac agc atg aac gac gtg cgc cgg gcc    1296
Gln Gly Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala 
335                 340                 345                 350 

ttc ttg gga ccc ttt gca cac aag gag ggg ccc atg cac cag tgg gtg    1344
Phe Leu Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val 
                355                 360                 365     

tca tac cag ggt cgc gtc ccc tac ccg cgg cca ggc atg tgc ccc agc    1392
Ser Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser 
            370                 375                 380         

aag acc ttt ggc acc ttc agt tcc acc aag gac ttc cca gac gat gtc    1440
Lys Thr Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val 
        385                 390                 395             

atc cag ttt gcg cgg aac cac ccc ctc atg tac aac tct gtc ctg ccc    1488
Ile Gln Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro 
    400                 405                 410                 

act ggg ggg cgc cct ctt ttc cta caa gtt gga gcc aat tac acc ttc    1536
Thr Gly Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe 
415                 420                 425                 430 

act caa att gcc gcg gac cgg gtt gca gcc gct gac gga cac tat gac    1584
Thr Gln Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp 
                435                 440                 445     

gtc ctc ttc att ggc aca gac gtt ggc acg gtg ctg aag gtg atc tcg    1632
Val Leu Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser 
            450                 455                 460         

gtc ccc aag ggc agt agg ccc agc gca gag ggg ctg ctc ctg gag gag    1680
Val Pro Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu 
        465                 470                 475             

ctg cac gtg ttt gag gac tcg gcc gct gtc acc agc atg caa att tct    1728
Leu His Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser 
    480                 485                 490                 

tcc aag agg cac cag ctg tac gta gcc tcg cgg agc gcg gtg gcc cag    1776
Ser Lys Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln 
495                 500                 505                 510 

atc gcg ttg cac cgc tgc gct gcc cac ggc cgc gtc tgc acc gaa tgc    1824
Ile Ala Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys 
                515                 520                 525     

tgt ctg gcg cgt gac ccc tac tgc gcc tgg gac ggg gtc gcg tgc acg    1872
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr 
            530                 535                 540         

cgc ttc cag ccc agt gcc aag agg cgg ttc cgg cgg caa gac gta agg    1920
Arg Phe Gln Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg 
        545                 550                 555             

aat ggc gac ccc agc acg ttg tgc tcc gga gac tcg tct cgt ccc gcg    1968
Asn Gly Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala 
    560                 565                 570                 

ctg ctg gaa cac aag gtg ttc ggc gtg gag ggc agc agc gcc ttt ctg    2016
Leu Leu Glu His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu 
575                 580                 585                 590 

gag tgt gag ccc cgc tcg ctg cag gcg cgc gtg gag tgg act ttc cag    2064
Glu Cys Glu Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln 
                595                 600                 605     

cgc gca ggg gtg aca gcc cac acc cag gtg ctg gca gag gag cgc acc    2112
Arg Ala Gly Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr 
            610                 615                 620         

gag cgc acc gcc cgg gga cta ctg ctg cgc agg ctg cgg cgc cgg gac    2160
Glu Arg Thr Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp 
        625                 630                 635             

tcg ggc gtg tac ttg tgc gcc gcc gtc gag cag ggc ttt acg caa ccg    2208
Ser Gly Val Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro 
    640                 645                 650                 

ctg cgt cgc ctg tcg ctg cac gtg ttg agt gct acg cag gcc gaa cga    2256
Leu Arg Arg Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg 
655                 660                 665                 670 

ctg gcg cgg gcc gag gag gct gcg ccc gcc gcg ccg ccg ggc ccc aaa    2304
Leu Ala Arg Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys 
                675                 680                 685     

ctc tgg tac cgg gac ttt ctg cag ctg gtg gag ccg ggc gga ggt ggc    2352
Leu Trp Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly 
            690                 695                 700         

agc gcg aac tcc ctg cgc atg tgc cgc ccg cag cct gcg ctg cag tca    2400
Ser Ala Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser 
        705                 710                 715             

ctg ccc ctg gag tcg cgg aga aag ggc cgt aac cgg agg acc cac gcc    2448
Leu Pro Leu Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala 
    720                 725                 730                 

cct gag cct cgc gct gag cgg ggg ccg cgc agc gca acg cac tgg tga    2496
Pro Glu Pro Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp     
735                 740                 745                     

ccagactgtc cccacgccgg gaaccaagca ggagacgaca ggcgagagag gagccagaca  2556

gaccctgaaa agaaggacgg gttggggccg ggcacattgg gggtcaccgg ccgatggaga  2616

caccaaccga caggccctgg ctgagggcag ctgcgcgggc ttatttatta acaggataac  2676

ccttgaatgt agcagccccg ggagggcggc acaggtcggg cgcaggattc agccggaggg  2736

aagggacggg gaagccgagc tccagagcaa cgaccagggc cgaggaggtg cctggagtgc  2796

ccaccctggg agacagaccc cacctccttg ggtagtgagc agtgagcaga aagctgtgaa  2856

caggctgggc tgctggaggt ggggcgaggc aggccgactg tactaaagta acgcaataaa  2916

cgcattatca gccaaagctg gaatggcccc agcagaaaac cccagaaaaa aaaaaaaaaa  2976

aaaaa                                                              2981

<210> 62
<211> 749
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:247..2496 from SEQ ID NO 61

<400> 62
Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Lys Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 
Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg Asn Gly 
545                 550                 555                 560 
Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala Leu Leu 
                565                 570                 575     
Glu His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu Glu Cys 
            580                 585                 590         
Glu Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln Arg Ala 
        595                 600                 605             
Gly Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr Glu Arg 
    610                 615                 620                 
Thr Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp Ser Gly 
625                 630                 635                 640 
Val Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro Leu Arg 
                645                 650                 655     
Arg Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg Leu Ala 
            660                 665                 670         
Arg Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys Leu Trp 
        675                 680                 685             
Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Ser Ala 
    690                 695                 700                 
Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser Leu Pro 
705                 710                 715                 720 
Leu Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala Pro Glu 
                725                 730                 735     
Pro Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp 
            740                 745                 

<210> 63
<211> 3746
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length mouse Sema3B A105K, transcript variant 1

<220> 
<221> CDS
<222> 400..2649
<223> /transl_table=1

<400> 63
agtgaaaggc ccaaggctcc tggtggtggc ccctcctgcc acccctccac ctcagctctg    60

acatggccca ctgaagggaa gggcaagagg caaggagggg aggaactgat ctttccaaaa   120

gctcctggga cctgagcttg ctgtggagtg tacagtcatc ccttagctgt ggagggacag   180

caactgcttt gctctttgca cttggtgccc tctggaatga ccacaggatc tgactctcat   240

ctgtcggctc ttcgcccttt actgcctggg gaccttgtcc gcatcatcag tatccttgtc   300

tctgccccag gctggcatga aatcctgggg cagagtccag gactgctgaa ggctcctcca   360

cacacgcctg ctgaaccctg agcgccctga gctgccggc atg ggg cgg gct gag      414
                                           Met Gly Arg Ala Glu 
                                           1               5   

gcc gcc gcc atg atc cca ggc ctg gcc ctt ctc tgg gta gca ggg cta     462
Ala Ala Ala Met Ile Pro Gly Leu Ala Leu Leu Trp Val Ala Gly Leu 
                10                  15                  20      

ggg gat act gcc cct aac ctt ccc cgc ctt cgg ctc tcc ttt caa gaa     510
Gly Asp Thr Ala Pro Asn Leu Pro Arg Leu Arg Leu Ser Phe Gln Glu 
            25                  30                  35          

tta cag gcc cgg cat ggt gtc cga acc ttc agg ctg gag cgg acc tgc     558
Leu Gln Ala Arg His Gly Val Arg Thr Phe Arg Leu Glu Arg Thr Cys 
        40                  45                  50              

tgt tat gaa gcc ttg ctg gtg gat gag gag cgt gga cgc ctg ttt gtg     606
Cys Tyr Glu Ala Leu Leu Val Asp Glu Glu Arg Gly Arg Leu Phe Val 
    55                  60                  65                  

ggt gct gag aac cac gtg gct tcc ctc agc ctg gac aac atc agc aag     654
Gly Ala Glu Asn His Val Ala Ser Leu Ser Leu Asp Asn Ile Ser Lys 
70                  75                  80                  85  

cga gcc aag aag ctg gcc tgg ccc gcc ccc gtg gaa tgg cgt gaa gaa     702
Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val Glu Trp Arg Glu Glu 
                90                  95                  100     

tgc aac tgg aag ggg aag gac att ggt acc gag tgc atg aac ttc gtg     750
Cys Asn Trp Lys Gly Lys Asp Ile Gly Thr Glu Cys Met Asn Phe Val 
            105                 110                 115         

aag ctg ctg cac acc tac aac cac acc cac ttg ctg gcc tgt ggc aca     798
Lys Leu Leu His Thr Tyr Asn His Thr His Leu Leu Ala Cys Gly Thr 
        120                 125                 130             

ggg gct ttc cac cca acc tgt gcc ttt gtg gag gtg ggc cac cgg ctg     846
Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu Val Gly His Arg Leu 
    135                 140                 145                 

gag gaa ccc atg ctt caa ctg gac cgg agg aaa ctt gag gac ggc aag     894
Glu Glu Pro Met Leu Gln Leu Asp Arg Arg Lys Leu Glu Asp Gly Lys 
150                 155                 160                 165 

ggg aag act cct tat gac cca agg cat cgg gct gcc tcg gtg ctg gtg     942
Gly Lys Thr Pro Tyr Asp Pro Arg His Arg Ala Ala Ser Val Leu Val 
                170                 175                 180     

ggg gaa gaa ctg tat tct ggg gtg aca gca gac ctt atg ggc cgg gac     990
Gly Glu Glu Leu Tyr Ser Gly Val Thr Ala Asp Leu Met Gly Arg Asp 
            185                 190                 195         

ttt acc atc ttt cga agc ctt ggt cag aat ccg agt ctc cga aca gag    1038
Phe Thr Ile Phe Arg Ser Leu Gly Gln Asn Pro Ser Leu Arg Thr Glu 
        200                 205                 210             

ccc cat gat tcc cgc tgg ctc aat gaa ccc aag ttt gtc aag gtc ttt    1086
Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys Phe Val Lys Val Phe 
    215                 220                 225                 

tgg atc cca gag agt gag aac cct gat gac gat aaa atc tat ttc ttc    1134
Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp Lys Ile Tyr Phe Phe 
230                 235                 240                 245 

ttc cgc gag tcc gct gtg gaa gca gca cca gca atg ggg cgc atg tct    1182
Phe Arg Glu Ser Ala Val Glu Ala Ala Pro Ala Met Gly Arg Met Ser 
                250                 255                 260     

gtg tct cgt gtt ggc cag atc tgc agg aat gac ctg ggt ggc cag cgg    1230
Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp Leu Gly Gly Gln Arg 
            265                 270                 275         

agc ttg gtc aac aaa tgg acc aca ttt ctg aag gcg cgg ctt gtg tgc    1278
Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val Cys 
        280                 285                 290             

tca gta cct gga gtt gag ggt gac acc cac ttt gac caa ctt cag gat    1326
Ser Val Pro Gly Val Glu Gly Asp Thr His Phe Asp Gln Leu Gln Asp 
    295                 300                 305                 

gtt ttc ctt ctg tcc tcc cga gac cgc cag aca cct ctt ctc tat gct    1374
Val Phe Leu Leu Ser Ser Arg Asp Arg Gln Thr Pro Leu Leu Tyr Ala 
310                 315                 320                 325 

gtc ttc tcc acc tcc agt ggt gtc ttc cag ggc tct gct gtg tgc gtg    1422
Val Phe Ser Thr Ser Ser Gly Val Phe Gln Gly Ser Ala Val Cys Val 
                330                 335                 340     

tac agc atg aac gat gtg cgc cga gcc ttc ttg gga cct ttt gct cac    1470
Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu Gly Pro Phe Ala His 
            345                 350                 355         

aaa gag ggg cct aca cac cag tgg gtg tcc tac cag ggt cgt gtc ccc    1518
Lys Glu Gly Pro Thr His Gln Trp Val Ser Tyr Gln Gly Arg Val Pro 
        360                 365                 370             

tac cca aga cct ggc atg tgc ccc agc aag acc ttt ggc acc ttc agc    1566
Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr Phe Gly Thr Phe Ser 
    375                 380                 385                 

tcc acc aag gac ttc cca gat gac gtt atc cag ttt gct cgg aac cac    1614
Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln Phe Ala Arg Asn His 
390                 395                 400                 405 

cct ctc atg tac aac cca gtc ctg ccc atg ggg ggg cgc cct ctc ttc    1662
Pro Leu Met Tyr Asn Pro Val Leu Pro Met Gly Gly Arg Pro Leu Phe 
                410                 415                 420     

cta caa gtg gga gct ggg tac acc ttc acc caa atc gcc gca gac cga    1710
Leu Gln Val Gly Ala Gly Tyr Thr Phe Thr Gln Ile Ala Ala Asp Arg 
            425                 430                 435         

gta gca gct gcc gat gga cac tac gat gtt ctc ttc att ggt aca gat    1758
Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu Phe Ile Gly Thr Asp 
        440                 445                 450             

gtg ggc aca gtg ctg aaa gtg atc tca gtc ccc aaa ggc agc cga cct    1806
Val Gly Thr Val Leu Lys Val Ile Ser Val Pro Lys Gly Ser Arg Pro 
    455                 460                 465                 

aat tct gaa gga ctt ctc ctg gaa gag ctg cag gtg ttc gag gac tct    1854
Asn Ser Glu Gly Leu Leu Leu Glu Glu Leu Gln Val Phe Glu Asp Ser 
470                 475                 480                 485 

gcc gct atc acc agc atg caa atc tcc tct aaa agg caa caa ctc tac    1902
Ala Ala Ile Thr Ser Met Gln Ile Ser Ser Lys Arg Gln Gln Leu Tyr 
                490                 495                 500     

ata gca tcg cgc agc gca gtg gcc cag att gct ttg cat cgc tgc act    1950
Ile Ala Ser Arg Ser Ala Val Ala Gln Ile Ala Leu His Arg Cys Thr 
            505                 510                 515         

gcc cta ggc cgc gcc tgc gca gaa tgc tgc ttg gcc cgt gat cct tac    1998
Ala Leu Gly Arg Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr 
        520                 525                 530             

tgc gcc tgg gat gga tca gct tgc aca cgc ttc cag cct acg gcc aag    2046
Cys Ala Trp Asp Gly Ser Ala Cys Thr Arg Phe Gln Pro Thr Ala Lys 
    535                 540                 545                 

aga cgg ttc cgg agg caa gac ata agg aat ggc gac ccc agc acc cta    2094
Arg Arg Phe Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Ser Thr Leu 
550                 555                 560                 565 

tgc tct gga gac tct tct cac tct gtg ctg ctg gag aag aag gtg ttg    2142
Cys Ser Gly Asp Ser Ser His Ser Val Leu Leu Glu Lys Lys Val Leu 
                570                 575                 580     

ggt gtg gag agc ggc agc gcg ttt ctg gag tgt gag ccc cgc tcg ctc    2190
Gly Val Glu Ser Gly Ser Ala Phe Leu Glu Cys Glu Pro Arg Ser Leu 
            585                 590                 595         

cag gcg cat gtg cag tgg acc ttc caa ggt gca ggg gag gca gct cac    2238
Gln Ala His Val Gln Trp Thr Phe Gln Gly Ala Gly Glu Ala Ala His 
        600                 605                 610             

acc cag gtg ctg gct gag gag aga gta gag cgc act gcg cgg ggg ctg    2286
Thr Gln Val Leu Ala Glu Glu Arg Val Glu Arg Thr Ala Arg Gly Leu 
    615                 620                 625                 

ctg ttg cgg ggg ctg cgg cgc cag gac tct ggc gtg tat ctt tgc gtc    2334
Leu Leu Arg Gly Leu Arg Arg Gln Asp Ser Gly Val Tyr Leu Cys Val 
630                 635                 640                 645 

gcg gtt gaa caa ggc ttt tca caa cca ctg cgt cgc ctg gtg ctg cat    2382
Ala Val Glu Gln Gly Phe Ser Gln Pro Leu Arg Arg Leu Val Leu His 
                650                 655                 660     

gtg ttg agt gcg gcg cag gct gaa cga ctg gca cgg gca gag gaa gca    2430
Val Leu Ser Ala Ala Gln Ala Glu Arg Leu Ala Arg Ala Glu Glu Ala 
            665                 670                 675         

gcc gct cct gca cct cct ggc cct aaa ctc tgg tac cgg gac ttt ctg    2478
Ala Ala Pro Ala Pro Pro Gly Pro Lys Leu Trp Tyr Arg Asp Phe Leu 
        680                 685                 690             

cag ttg gtg gag cca ggc ggt ggc gga ggt gca aac tcc ctg cga atg    2526
Gln Leu Val Glu Pro Gly Gly Gly Gly Gly Ala Asn Ser Leu Arg Met 
    695                 700                 705                 

tgc cgc ccg cag ccc ggg cac cac tct gtg gca gca gat tca cgt cgt    2574
Cys Arg Pro Gln Pro Gly His His Ser Val Ala Ala Asp Ser Arg Arg 
710                 715                 720                 725 

aag ggt cgc aac aga cgg atg cat gtc tct gag ctc cgt gct gag cgt    2622
Lys Gly Arg Asn Arg Arg Met His Val Ser Glu Leu Arg Ala Glu Arg 
                730                 735                 740     

gga cca cgt agt gca gct cac tgg tga ctcggctgtc cccacaatgg          2669
Gly Pro Arg Ser Ala Ala His Trp                           
            745                                           

gacgaggctg aatatgacac tccaaagagg ggcagacaga tgccaggaag acaaatgagt  2729

tatggctggg ccacactgag gtccttgggc caacagagac acctaaccct tacataggcc  2789

ctggccaaag ggtagcttat ttattaacaa gataacccgt ggatgtagcc tcaaagagtg  2849

gcctaagctc aattcaggat ctaaccagga gggaggggac agagacgtgg ggttccagag  2909

tggaccagga ccagagagtt gtcttgggtg gcagccctgg ggaaagaatt ctctttcttg  2969

ggcagcaagc agcaagctgt gaacagatta gaccgttggg tatggggtga ggcaggccaa  3029

ctgtactaaa gtaacgcaat aaacacatta tcagctgaca ttggaatggc cccagcagac  3089

aacaggtagt cctagacctt gctgggggct cttgggtatc gccctagggg tctcaagacc  3149

tgcattttcc tcatccaaga atgctaaagt gaagattaaa cgtgttagta gacgactacg  3209

ctggttccag tgagcctctg gggtactggc aatacacagt gcattagtgg caggaccaag  3269

ctctctgaag taaaaccaat actggctgtt gtgggcaagg atgtattaat tcactgaacg  3329

ggtggtgttt gagctgaata agaaggagcc aatcaccaat gtctggtgac agaacattcc  3389

gggatagaag aaccagggca acaacgtcgt ggagcagggg acagaccctc caagtctgcg  3449

gaacaaccag gaggctgata tggtgttatg gcactatgga ctcctgatgg tttggaaggt  3509

agatcccacc agccctgctt ttcaccgttg agaaacagaa cagagtccac ccagactaag  3569

gcctgcaagc tggaccagca cccttcaaga gagccacgtg cctctctctc cgtggcctgt  3629

caagcccttg tgaagaggag agggaggacc caaaacctct taagtgcttt agccatgctt  3689

cttcattttt attctcagta cagttggcca ggaacctttg ttcctgtttt acagatg     3746

<210> 64
<211> 749
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:400..2649 from SEQ ID NO 63

<400> 64
Met Gly Arg Ala Glu Ala Ala Ala Met Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Val Ala Gly Leu Gly Asp Thr Ala Pro Asn Leu Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Arg His Gly Val Arg Thr Phe Arg 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Glu Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Ser Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Lys Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Thr Tyr Asn His Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Leu Glu Glu Pro Met Leu Gln Leu Asp Arg Arg Lys 
145                 150                 155                 160 
Leu Glu Asp Gly Lys Gly Lys Thr Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Thr Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Asn Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Met Gly Arg Met Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Leu Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp Arg Gln Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Gly Val Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Thr His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Pro Val Leu Pro Met Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Gly Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Asn Ser Glu Gly Leu Leu Leu Glu Glu Leu Gln 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Ile Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg Gln Gln Leu Tyr Ile Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Thr Ala Leu Gly Arg Ala Cys Ala Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Thr Ala Lys Arg Arg Phe Arg Arg Gln Asp Ile Arg Asn Gly 
545                 550                 555                 560 
Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser His Ser Val Leu Leu 
                565                 570                 575     
Glu Lys Lys Val Leu Gly Val Glu Ser Gly Ser Ala Phe Leu Glu Cys 
            580                 585                 590         
Glu Pro Arg Ser Leu Gln Ala His Val Gln Trp Thr Phe Gln Gly Ala 
        595                 600                 605             
Gly Glu Ala Ala His Thr Gln Val Leu Ala Glu Glu Arg Val Glu Arg 
    610                 615                 620                 
Thr Ala Arg Gly Leu Leu Leu Arg Gly Leu Arg Arg Gln Asp Ser Gly 
625                 630                 635                 640 
Val Tyr Leu Cys Val Ala Val Glu Gln Gly Phe Ser Gln Pro Leu Arg 
                645                 650                 655     
Arg Leu Val Leu His Val Leu Ser Ala Ala Gln Ala Glu Arg Leu Ala 
            660                 665                 670         
Arg Ala Glu Glu Ala Ala Ala Pro Ala Pro Pro Gly Pro Lys Leu Trp 
        675                 680                 685             
Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Gly Ala 
    690                 695                 700                 
Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Gly His His Ser Val Ala 
705                 710                 715                 720 
Ala Asp Ser Arg Arg Lys Gly Arg Asn Arg Arg Met His Val Ser Glu 
                725                 730                 735     
Leu Arg Ala Glu Arg Gly Pro Arg Ser Ala Ala His Trp 
            740                 745                 

<210> 65
<211> 5189
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length human SEMA3C A104K

<220> 
<221> CDS
<222> 563..2818
<223> /transl_table=1

<400> 65
ggactgcgaa aggagcaggg ttgcggagct agggctccag cctgcggccg cgcattcttg    60

cgtctggcca gccgcgagct ctaagggtcg gccccgcccg gtccgccccc gcggctccct   120

gccaggctct cgcgggcgcg ctcggggtgg ggcctcgcgg ctggcggaga tgcggccggg   180

gctgcgcggt ggtgatgcga gcctgctggg cggcgcgccg gggcagccgg agccgcgcgc   240

cgcggcgctg taatcggaca ccaagagcgc tcgcccccgg cctccggcca ctttccattc   300

actccgaggt gcttgattga gcgacgcgga gaagagctcc gggtgccgcg gcactgcagc   360

gctgagattc ctttacaaag aaactcagag gaccgggaag aaagaatttc acctttgcga   420

cgtgctagaa aataaggtcg tctgggaaaa ggactggaga cacaagcgca tccaaccccg   480

gtagcaaact gatgactttt ccgtgctgat ttctttcaac ctcggtattt tcccttggat   540

attaacttgc atatctgaag aa atg gca ttc cgg aca att tgc gtg ttg gtt    592
                         Met Ala Phe Arg Thr Ile Cys Val Leu Val 
                         1               5                   10  

gga gta ttt att tgt tct atc tgt gtg aaa gga tct tcc cag ccc caa     640
Gly Val Phe Ile Cys Ser Ile Cys Val Lys Gly Ser Ser Gln Pro Gln 
                15                  20                  25      

gca aga gtt tat tta aca ttt gat gaa ctt cga gaa acc aag acc tct     688
Ala Arg Val Tyr Leu Thr Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser 
            30                  35                  40          

gaa tac ttc agc ctt tcc cac cat cct tta gac tac agg att tta tta     736
Glu Tyr Phe Ser Leu Ser His His Pro Leu Asp Tyr Arg Ile Leu Leu 
        45                  50                  55              

atg gat gaa gat cag gac cgg ata tat gtg gga agc aaa gat cac att     784
Met Asp Glu Asp Gln Asp Arg Ile Tyr Val Gly Ser Lys Asp His Ile 
    60                  65                  70                  

ctt tcc ctg aat att aac aat ata agt caa gaa gct ttg agt gtt ttc     832
Leu Ser Leu Asn Ile Asn Asn Ile Ser Gln Glu Ala Leu Ser Val Phe 
75                  80                  85                  90  

tgg cca gca tct aca atc aaa gtt gaa gaa tgc aaa atg aag ggc aaa     880
Trp Pro Ala Ser Thr Ile Lys Val Glu Glu Cys Lys Met Lys Gly Lys 
                95                  100                 105     

gat ccc aca cac ggc tgt ggg aac ttt gtc cgt gta att cag act ttc     928
Asp Pro Thr His Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe 
            110                 115                 120         

aat cgc aca cat ttg tat gtc tgt ggg agt ggc gct ttc agt cct gtc     976
Asn Arg Thr His Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val 
        125                 130                 135             

tgt act tac ttg aac aga ggg agg aga tca gag gac caa gtt ttc atg    1024
Cys Thr Tyr Leu Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met 
    140                 145                 150                 

att gac tcc aag tgt gaa tct gga aaa gga cgc tgc tct ttc aac ccc    1072
Ile Asp Ser Lys Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro 
155                 160                 165                 170 

aac gtg aac acg gtg tct gtt atg atc aat gag gag ctt ttc tct gga    1120
Asn Val Asn Thr Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly 
                175                 180                 185     

atg tat ata gat ttc atg ggg aca gat gct gct att ttt cga agt tta    1168
Met Tyr Ile Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu 
            190                 195                 200         

acc aag agg aat gcg gtc aga act gat caa cat aat tcc aaa tgg cta    1216
Thr Lys Arg Asn Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu 
        205                 210                 215             

agt gaa cct atg ttt gta gat gca cat gtc atc cca gat ggt act gat    1264
Ser Glu Pro Met Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp 
    220                 225                 230                 

cca aat gat gct aag gtg tac ttc ttc ttc aaa gaa aaa ctg act gac    1312
Pro Asn Asp Ala Lys Val Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp 
235                 240                 245                 250 

aat aac agg agc acg aaa cag att cat tcc atg att gct cga ata tgt    1360
Asn Asn Arg Ser Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys 
                255                 260                 265     

cct aat gac act ggt gga ctg cgt agc ctt gtc aac aag tgg acc act    1408
Pro Asn Asp Thr Gly Gly Leu Arg Ser Leu Val Asn Lys Trp Thr Thr 
            270                 275                 280         

ttc tta aag gcg agg ctg gtg tgc tcg gta aca gat gaa gac ggc cca    1456
Phe Leu Lys Ala Arg Leu Val Cys Ser Val Thr Asp Glu Asp Gly Pro 
        285                 290                 295             

gaa aca cac ttt gat gaa tta gag gat gtg ttt ctg ctg gaa act gat    1504
Glu Thr His Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Glu Thr Asp 
    300                 305                 310                 

aac ccg agg aca aca cta gtg tat ggc att ttt aca aca tca agc tca    1552
Asn Pro Arg Thr Thr Leu Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser 
315                 320                 325                 330 

gtt ttc aaa gga tca gcc gtg tgt gtg tat cat tta tct gat ata cag    1600
Val Phe Lys Gly Ser Ala Val Cys Val Tyr His Leu Ser Asp Ile Gln 
                335                 340                 345     

act gtg ttt aat ggg cct ttt gcc cac aaa gaa ggg ccc aat cat cag    1648
Thr Val Phe Asn Gly Pro Phe Ala His Lys Glu Gly Pro Asn His Gln 
            350                 355                 360         

ctg att tcc tat cag ggc aga att cca tat cct cgc cct gga act tgt    1696
Leu Ile Ser Tyr Gln Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys 
        365                 370                 375             

cca gga gga gca ttt aca ccc aat atg cga acc acc aag gag ttc cca    1744
Pro Gly Gly Ala Phe Thr Pro Asn Met Arg Thr Thr Lys Glu Phe Pro 
    380                 385                 390                 

gat gat gtt gtc act ttt att cgg aac cat cct ctc atg tac aat tcc    1792
Asp Asp Val Val Thr Phe Ile Arg Asn His Pro Leu Met Tyr Asn Ser 
395                 400                 405                 410 

atc tac cca atc cac aaa agg cct ttg att gtt cgt att ggc act gac    1840
Ile Tyr Pro Ile His Lys Arg Pro Leu Ile Val Arg Ile Gly Thr Asp 
                415                 420                 425     

tac aag tat aca aag ata gct gtg gat cga gtg aac gct gct gat ggg    1888
Tyr Lys Tyr Thr Lys Ile Ala Val Asp Arg Val Asn Ala Ala Asp Gly 
            430                 435                 440         

aga tac cat gtc ctg ttt ctc gga aca gat cgg ggt act gtg caa aaa    1936
Arg Tyr His Val Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys 
        445                 450                 455             

gtg gtt gtt ctt cct act aac aac tct gtc agt ggc gag ctc att ctg    1984
Val Val Val Leu Pro Thr Asn Asn Ser Val Ser Gly Glu Leu Ile Leu 
    460                 465                 470                 

gag gag ctg gaa gtc ttt aag aat cat gct cct ata aca aca atg aaa    2032
Glu Glu Leu Glu Val Phe Lys Asn His Ala Pro Ile Thr Thr Met Lys 
475                 480                 485                 490 

att tca tct aaa aag caa cag ttg tat gtg agt tcc aat gaa ggg gtt    2080
Ile Ser Ser Lys Lys Gln Gln Leu Tyr Val Ser Ser Asn Glu Gly Val 
                495                 500                 505     

tcc cag gta tct ctg cac cgc tgc cac atc tat ggt aca gcc tgt gct    2128
Ser Gln Val Ser Leu His Arg Cys His Ile Tyr Gly Thr Ala Cys Ala 
            510                 515                 520         

gac tgc tgc ctg gcg cgg gac cct tat tgc gcc tgg gat ggc cat tcc    2176
Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly His Ser 
        525                 530                 535             

tgt tcc aga ttc tac cca act ggg aaa cgg agg agc cga aga caa gat    2224
Cys Ser Arg Phe Tyr Pro Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp 
    540                 545                 550                 

gtg aga cat gga aac cca ctg act caa tgc aga gga ttt aat cta aaa    2272
Val Arg His Gly Asn Pro Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys 
555                 560                 565                 570 

gca tac aga aat gca gct gaa att gtc cag tat gga gta aaa aat aac    2320
Ala Tyr Arg Asn Ala Ala Glu Ile Val Gln Tyr Gly Val Lys Asn Asn 
                575                 580                 585     

acc act ttt ctg gag tgt gcc ccc aag tct ccg cag gca tct atc aag    2368
Thr Thr Phe Leu Glu Cys Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys 
            590                 595                 600         

tgg ctg tta cag aaa gac aaa gac agg agg aaa gag gtt aag ctg aat    2416
Trp Leu Leu Gln Lys Asp Lys Asp Arg Arg Lys Glu Val Lys Leu Asn 
        605                 610                 615             

gaa cga ata ata gcc act tca cag gga ctc ctg atc cgc tct gtt cag    2464
Glu Arg Ile Ile Ala Thr Ser Gln Gly Leu Leu Ile Arg Ser Val Gln 
    620                 625                 630                 

ggt tct gac caa gga ctt tat cac tgc att gct aca gaa aat agt ttc    2512
Gly Ser Asp Gln Gly Leu Tyr His Cys Ile Ala Thr Glu Asn Ser Phe 
635                 640                 645                 650 

aag cag acc ata gcc aag atc aac ttc aaa gtt tta gat tca gaa atg    2560
Lys Gln Thr Ile Ala Lys Ile Asn Phe Lys Val Leu Asp Ser Glu Met 
                655                 660                 665     

gtg gct gtt gtg acg gac aaa tgg tcc cca tgg acc tgg gcc agc tct    2608
Val Ala Val Val Thr Asp Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser 
            670                 675                 680         

gtg agg gct tta ccc ttc cac ccg aag gac atc atg ggg gca ttc agc    2656
Val Arg Ala Leu Pro Phe His Pro Lys Asp Ile Met Gly Ala Phe Ser 
        685                 690                 695             

cac tca gaa atg cag atg att aac caa tat tgc aaa gac act cgg cag    2704
His Ser Glu Met Gln Met Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln 
    700                 705                 710                 

caa cat cag cag gga gat gaa tca cag aaa atg aga ggg gac tat ggc    2752
Gln His Gln Gln Gly Asp Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly 
715                 720                 725                 730 

aag tta aag gcc ctc atc aat agt cgg aaa agt aga aac agg agg aat    2800
Lys Leu Lys Ala Leu Ile Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn 
                735                 740                 745     

cag ttg cca gag tca taa tattttctta tgtgggtctt atgcttccat           2848
Gln Leu Pro Glu Ser                                      
            750                                          

taacaaatgc tctgtcttca atgatcaaat tttgagcaaa gaaacttgtg ctttaccaag  2908

gggaattact gaaaaaggtg attactcctg aagtgagttt tacacgaact gaaatgagca  2968

tgcattttct tgtatgatag tgactagcac tagacatgtc atggtcctca tggtgcatat  3028

aaatatattt aacttaaccc agattttatt tatatcttta ttcacctttt cttcaaaatc  3088

gatatggtgg ctgcaaaact agaattgttg catccctcaa ttgaatgagg gccatatccc  3148

tgtggtattc ctttcctgct ttggggcttt agaattctaa ttgtcagtga ttttgtatat  3208

gaaaacaagt tccaaatcca cagcttttac gtagtaaaag tcataaatgc atatgacaga  3268

atggctatca aaagaaatag aaaaggaaga cagcatttaa agttgtataa aaacatgagt  3328

tattcataaa gagaaaatga tgagttttta tggttccaat gaaatatgtt ggggtttttt  3388

taagattgta aaaataatca gttactggta tctgtcactg acctttgttt ccttattcag  3448

gaagataaaa atcagtaacc taccccatga agatatttgg tgggagttat atcagtgaag  3508

cagtttggtt tatattctta tgttatcacc ttccaaacaa aagcacttac tttttttgga  3568

agttatttat tttagactca aagaatataa tctggcacta ctcagttatt actgtttgtt  3628

ctcttattcc ctagtctgtg tggcaaatta aacaatataa gaaggaaaaa tttgaagtat  3688

tagacttcta aataaggtgt gaaatcatca aaaagaaaaa tcaaagtaga aactactaat  3748

tttttaagag gaatttataa caaatatggc tagttttcaa cttcagtact caaattcaat  3808

gattcttcct tttattaaaa ccagtctcag atatcatact gatttttaag tcaacactat  3868

atattttatg atcttttcag tgtgatggca aggtgcttgt tatgtctaga aagtaagaaa  3928

acaatatgag gagacattct gtctttcaaa aggtaatggt acatacgttc actggtctct  3988

aagtgtaaaa gtagtaaatt ttgtgatgaa taaaataatt atctcctaat tgtatgttag  4048

aataatttta ttagaataat ttcatactga aattattttc tccaaataaa aattagatgg  4108

aaaaatgtga aaaaaattat tcatgctctc atatatattt taaaaacact acttttgctt  4168

ttttatttac cttttaagac attttcatgc ttccaggtaa aaacagatat tgtaccatgt  4228

acctaatcca aatatcatat aaacatttta tttatagtta ataatctatg atgaaggtaa  4288

ttaaagtaga ttatggcctt tttaagtatt gcagtctaaa acttcaaaaa ctaaaatcat  4348

tgtcaaaatt aatatgatta ttaatcagaa tatcagaata tgattcacta tttaaactat  4408

gataaattat gataatatat gaggaggcct cgctatagca aaaatagtta aaatgctgac  4468

ataacaccaa acttcatttt ttaaaaaatc tgttgttcca aatgtgtata attttaaagt  4528

aatttctaaa gcagtttatt ataatggttt gcctgcttaa aaggtataat taaacttctt  4588

ttctcttcta cattgacaca cagaaatgtg tcaatgtaaa gccaaaacca tcttctgtgt  4648

ttatggccaa tctattctca aagttaaaag taaaattgtt tcagagtcac agttcccttt  4708

atttcacata agcccaaact gatagacagt aacggtgttt agttttatac tatatttgtg  4768

ctatttaatt ctttctattt tcacaattat taaattgtgt acactttcat tacttttaaa  4828

aatgtagaaa ttcttcatga acataactct gctgaatgta aaagaaaatt ttttttcaaa  4888

aatgctgtta atgtatacta ctggtggttg attggtttta ttttatgtag cttgacaatt  4948

cagtgactta atatctattc catttgtatt gtacataaaa ttttctagaa atacactttt  5008

ttccaaagtg taagtttgtg aatagatttt agcatgatga aactgtcata atggtgaatg  5068

ttcaatctgt gtaagaaaac aaactaaatg tagttgtcac actaaaattt aattggatat  5128

tgatgaaatc attggcctgg caaaataaaa catgttgaat tccccaaaaa aaaaaaaaaa  5188

a                                                                  5189

<210> 66
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:563..2818 from SEQ ID NO 65

<400> 66
Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      
Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          
Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              
His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  
Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  
Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      
Lys Val Glu Glu Cys Lys Met Lys Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         
Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             
Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 
Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 
Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     
Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         
Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             
Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 
Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 
Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     
Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         
Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             
Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 
Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 
Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     
Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         
Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             
Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 
Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 
Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     
Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         
Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             
Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 
Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 
Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     
Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         
Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             
Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 
Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 
Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     
Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         
Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             
Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 
Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 
Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     
Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         
Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             
His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 
Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 
Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     
Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     

<210> 67
<211> 4956
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length mouse Sema3C A104K

<220> 
<221> CDS
<222> 189..2444
<223> /transl_table=1

<400> 67
ctgctacaaa gaaactcagc accggccggc aggaatccca ccctccggac tcactaagtc    60

tttaaaggtc ttctggggaa aggacctagg ggactggaaa tccaagcccg gagcaagtgg   120

ctgacttctc ctggatcttt tcccacctcg gtattttccc ttggatatta attcccaaat   180

cagaagaa atg gca ttc cgg gcg att tgt gtg ttg gtt gga gta ttt att    230
         Met Ala Phe Arg Ala Ile Cys Val Leu Val Gly Val Phe Ile 
         1               5                   10                  

tgt tcc att tgt gta cga gga tct tcc cag ccc caa gca aga gtt tat     278
Cys Ser Ile Cys Val Arg Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr 
15                  20                  25                  30  

tta aca ttt gat gag ctt cga gaa acc aaa acc tct gag tac ttt agt     326
Leu Thr Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser 
                35                  40                  45      

ctg tcc cac cag cag tta gac tac aga ata ttg ctg atg gat gaa gat     374
Leu Ser His Gln Gln Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp 
            50                  55                  60          

caa gac cgg ata tat gtg ggg agc aaa gac cac atc ctg tct ttg aat     422
Gln Asp Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn 
        65                  70                  75              

atc aac aat atc agt caa gaa cct ttg agt gtt ttc tgg cca gca tca     470
Ile Asn Asn Ile Ser Gln Glu Pro Leu Ser Val Phe Trp Pro Ala Ser 
    80                  85                  90                  

aca atc aaa gtt gaa gag tgc aaa atg aag ggc aaa gat cct aca cat     518
Thr Ile Lys Val Glu Glu Cys Lys Met Lys Gly Lys Asp Pro Thr His 
95                  100                 105                 110 

ggc tgt gga aat ttc gtc cgg gtg att cag aca ttc aac cgt act cac     566
Gly Cys Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His 
                115                 120                 125     

ctg tat gtc tgt ggg agt gga gcg ttc agc cca gtg tgc acc tac ctg     614
Leu Tyr Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu 
            130                 135                 140         

aac cgg gga agg agg tca gag gac cag gta ttc atg atc gac tct aag     662
Asn Arg Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys 
        145                 150                 155             

tgt gaa tct ggc aaa gga cga tgc tct ttc aac ccg aat gtg aac act     710
Cys Glu Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr 
    160                 165                 170                 

gtg tct gtt atg atc aat gag gaa ctc ttc tca gga atg tat ata gac     758
Val Ser Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp 
175                 180                 185                 190 

ttc atg gga aca gat gct gct att ttc cga agt tta act aag agg aat     806
Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn 
                195                 200                 205     

gca gtt cga act gat caa cat aat tca aaa tgg ctg agt gaa ccc atg     854
Ala Val Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met 
            210                 215                 220         

ttt gtg gac gca cat gtg atc cca gat ggc act gat cca aat gat gct     902
Phe Val Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala 
        225                 230                 235             

aag gtc tat ttc ttc ttc aaa gaa aga ctg act gac aac aat agg agc     950
Lys Val Tyr Phe Phe Phe Lys Glu Arg Leu Thr Asp Asn Asn Arg Ser 
    240                 245                 250                 

aca aaa cag att cat tcc atg att gca aga ata tgc cct aat gac act     998
Thr Lys Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr 
255                 260                 265                 270 

ggt gga caa cgt agt ctt gtc aac aag tgg acc aca ttc tta aag gca    1046
Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala 
                275                 280                 285     

aga ctt gta tgc tca gtc aca gat gaa gat ggc cca gag aca cat ttt    1094
Arg Leu Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe 
            290                 295                 300         

gat gaa cta gag gat gtc ttt ctg ctg gaa act gac aat cca agg aca    1142
Asp Glu Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr 
        305                 310                 315             

aca ctc gtg tat ggc atc ttc acc aca tca agc tct gtt ttt aag gga    1190
Thr Leu Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly 
    320                 325                 330                 

tcg gca gtg tgt gtg tat cat tta tct gat ata cag act gta ttc aat    1238
Ser Ala Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn 
335                 340                 345                 350 

ggg ccc ttt gcc cac aag gaa ggg ccc aat cac cag ctg atc tcc tat    1286
Gly Pro Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr 
                355                 360                 365     

caa ggt aga atc cca tat cct cgc cca gga act tgc cca gga ggg gcc    1334
Gln Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala 
            370                 375                 380         

ttt aca ccc aat atg aga acc acc aag gac ttc cca gat gac gtt gtc    1382
Phe Thr Pro Asn Met Arg Thr Thr Lys Asp Phe Pro Asp Asp Val Val 
        385                 390                 395             

act ttt att cgg aac cac cct ctc atg tac aat tcc atc tac ccc atc    1430
Thr Phe Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile 
    400                 405                 410                 

cac aga agg cct ctg ata gtc cgc ata ggc act gac tac aag tac aca    1478
His Arg Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr 
415                 420                 425                 430 

aag att gct gtg gac cgt gtc aac gct gct gat ggg aga tac cac gtt    1526
Lys Ile Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val 
                435                 440                 445     

ctg ttt ctg ggc aca gat cgg ggc acc gtg cag aag gtc gta gtc ctt    1574
Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu 
            450                 455                 460         

cct acc aat agc tct gcc agt ggg gaa ctc atc ctg gag gag ctg gaa    1622
Pro Thr Asn Ser Ser Ala Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu 
        465                 470                 475             

gtc ttc aag aat cat gtt ccc ata aca aca atg aaa atc tca tcc aaa    1670
Val Phe Lys Asn His Val Pro Ile Thr Thr Met Lys Ile Ser Ser Lys 
    480                 485                 490                 

aag caa cag ttg tac gtg agc tcc aat gag ggg gtt tcc caa gtc tct    1718
Lys Gln Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser 
495                 500                 505                 510 

ctg cat cgc tgc cat atc tac ggc aca gcc tgt gcg gac tgc tgc ttg    1766
Leu His Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu 
                515                 520                 525     

gcg agg gat cca tac tgt gcc tgg gat ggc cac tct tgc tct agg ttc    1814
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe 
            530                 535                 540         

tac ccc act ggg aag cgg agg agc cga aga caa gat gtg aga cat gga    1862
Tyr Pro Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly 
        545                 550                 555             

aac cca ctg aca caa tgc cga ggg ttc aat ctg aaa gca tac aga aat    1910
Asn Pro Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn 
    560                 565                 570                 

gca gct gaa att gtt cag tat gga gta aga aat aac agc act ttc ctt    1958
Ala Ala Glu Ile Val Gln Tyr Gly Val Arg Asn Asn Ser Thr Phe Leu 
575                 580                 585                 590 

gag tgt gct ccc aag tct cca cag gca tct atc aag tgg ttg ctg cag    2006
Glu Cys Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln 
                595                 600                 605     

aaa gac aaa gac agg agg aag gag gtt aaa ctg aac gag cgc att ata    2054
Lys Asp Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile 
            610                 615                 620         

gct act tcc caa gga cta ctg att cgc tct gtt caa gat tct gac caa    2102
Ala Thr Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Asp Ser Asp Gln 
        625                 630                 635             

gga ctc tac cac tgc att gcc act gag aac agc ttc aaa cag acc ata    2150
Gly Leu Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile 
    640                 645                 650                 

gcc aag atc aac ttc aaa gtt tta gat tca gaa atg gtg gcc gtt gtg    2198
Ala Lys Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val 
655                 660                 665                 670 

aca gac aag tgg tcc ccg tgg aca tgg gct ggc tct gtg agg gct cta    2246
Thr Asp Lys Trp Ser Pro Trp Thr Trp Ala Gly Ser Val Arg Ala Leu 
                675                 680                 685     

ccc ttc cat cca aag gac atc ctg ggg gca ttc agc cac tcg gaa atg    2294
Pro Phe His Pro Lys Asp Ile Leu Gly Ala Phe Ser His Ser Glu Met 
            690                 695                 700         

cag ctc atc aat cag tac tgc aaa gac acc cgg cag cag cag cag ctg    2342
Gln Leu Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln Gln Gln Leu 
        705                 710                 715             

ggg gaa gaa cca cag aag atg aga ggg gac tat ggc aag ctg aag gct    2390
Gly Glu Glu Pro Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala 
    720                 725                 730                 

ctc atc aac agc agg aaa agc aga aac agg agg aat cag ctt cca gag    2438
Leu Ile Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu 
735                 740                 745                 750 

tca taa aacattcatc catgaagttt tgcttccagg aacaaatgct ctgtcttcac     2494
Ser                                                            
                                                               

tagtcaacta ttaaataaaa tcttgtgctt tacccatgag aaatttctga caaaagctgg  2554

agactcactc taaagtgtgt tctctgtgaa ctgaaaagag catgcatttt cttgtatgat  2614

acagactagc actagacatg tcatggtcct tgtggtgcat aaaaaatatt taacttatcc  2674

cagattttat ttatatcttt atgtgtcttt tcttcaaaat caatgcgaca acagaagcag  2734

aactgttaca gcctcggttg agcgagggcc ataaatttcc ctgtgctctt ccttccgtgc  2794

tctaggggtt tagctttcta attgtcactg gcttttatac atgaaaaaga attccagttc  2854

acaattttca catagtaaat gtcatataaa tgtgtgtgac atccagtgtc atgtaggtta  2914

cacaaatgac agggaagaga gcatccagat gttacgtaaa gtcaagagtg actcataaag  2974

agcaagtgat gagttcatat gcttccagtg atttatcttc ttgcttgttc ctttgtttaa  3034

gattgtaaga tgtgtcggct gctgatagct gccatcaatg tttgttctct tgttttagaa  3094

aaacaaaaga aatggcctgt accatccaag gcctttgatg ggagatctat cagtgagcca  3154

ttgacgtttc tactgttatg ttatcatctt ccaaacaaaa gtgctttgtt tttttggaag  3214

ttatttaagt tattatagac ttacataaac tattgcatta tttaattgat ttactgtttt  3274

ggttttaatc ccctagtcta cctggaaaat taaagacaac aaggatgcag tattattaaa  3334

gcattcaact tttccatgca gagtgaagct atccaaaggg aaaaggaaga ttaaaaaaaa  3394

agcatacaat ttgtcatgta aaggaattag taacatgtag tttgttttct accttagtaa  3454

tcaaattcta ggagtaattt gtacatccaa ggaaccagtt tcacaaagca taatgatttt  3514

tcaggcaagg tttcatgatt tgtaaacata tctgtgatgg gaaagttatt attacatcaa  3574

gaaagaaaat ctcaacacat tttaaacaaa acagacttct tttaaagact atctattttc  3634

acccagatat tttttccact tgataatact tctttaggaa tgttgataca catgtttaac  3694

tattggaaaa ttttagcact atcttctaat tatatacttg gattgtttaa tgagaaaagt  3754

ataatactaa aattagtttc tccaatttaa atgaataaaa tataggagat tttcttatat  3814

gtcttttaat tatacaactt tcattttatt taattttatt ttaatatgtt tatattttca  3874

gataaaaaga gaagttttac taaaacacca ttgaaacata cttcttatta acagttcatc  3934

tagaatgtaa ctacagggga tctacatcat tttataatgc tgtggaaaaa cctgcaggaa  3994

gtaaaactat ggataggagt gtaagttggt agtagactac gtgtttagca tgcacaaaga  4054

cctgggctca aacagaaaga aaggaagaaa gacaccaagg aaggagggca agcaggaaaa  4114

agaacagact gactggagag aagaagggca ggaaagtggt aaagaaggca aagaaagatg  4174

gagggaatac attcattatc agaagattaa aaaatggtag ttaaatgatg gtcaattctg  4234

gtgttcttaa gagtgcacct cagtgttgta gaaaacacca gttaaaatag cataaatgta  4294

cccaaatgtg tacagtgcta caataatcta tggggttagc atatggttaa aatgtttggt  4354

tagcatgttt aaaatgttca cactttgggt tttcttatac atataaaaat agccatgcgt  4414

tcacgtgtga tgctaacacc atcctctttc tgtgtttgta attaatctat tgtatggaaa  4474

cagctacttc cccttgctcc acttaccttc aaactgccag ccacttggct attatttgtt  4534

ctatttagta cctcctgggt tggtttttaa ccataattac atttcaaatc ttcatttctt  4594

tttctttaaa gatatagaaa ttgctgtgca gcatagcccg gccaaaacta aaacatatat  4654

ctctcaaaag cataactaat acatattgag tatgggtgat tactcggttt tattttgttt  4714

acttgggaaa attaataatt aaacatgttt ttcttttgta ttgtacataa aattacctag  4774

aaatgcactt ttcctccaaa atgtaggttc gtgaatagac ttagcatgat gaagctgtct  4834

ttacagtgaa tgcttaccct gtgtagagaa agcaaactag atgtagttac cacatgagaa  4894

tttaattaga tgttgaaaaa aataatttgt ctggaaaaat aaagcattca attcccctga  4954

aa                                                                 4956

<210> 68
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:189..2444 from SEQ ID NO 67

<400> 68
Met Ala Phe Arg Ala Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      
Ile Cys Val Arg Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          
Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              
His Gln Gln Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  
Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  
Asn Ile Ser Gln Glu Pro Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      
Lys Val Glu Glu Cys Lys Met Lys Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         
Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             
Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 
Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 
Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     
Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         
Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             
Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 
Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 
Tyr Phe Phe Phe Lys Glu Arg Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     
Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         
Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             
Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 
Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 
Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     
Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         
Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             
Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 
Pro Asn Met Arg Thr Thr Lys Asp Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 
Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Arg 
                405                 410                 415     
Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         
Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             
Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 
Asn Ser Ser Ala Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 
Lys Asn His Val Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     
Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         
Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             
Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 
Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 
Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     
Glu Ile Val Gln Tyr Gly Val Arg Asn Asn Ser Thr Phe Leu Glu Cys 
            580                 585                 590         
Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             
Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 
Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Asp Ser Asp Gln Gly Leu 
625                 630                 635                 640 
Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     
Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         
Lys Trp Ser Pro Trp Thr Trp Ala Gly Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             
His Pro Lys Asp Ile Leu Gly Ala Phe Ser His Ser Glu Met Gln Leu 
    690                 695                 700                 
Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln Gln Gln Leu Gly Glu 
705                 710                 715                 720 
Glu Pro Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     
Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     

<210> 69
<211> 6276
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length human SEMA3D A120K

<220> 
<221> CDS
<222> 41..2374
<223> /transl_table=1

<400> 69
attaaattaa caccatttga aagagaacat tgttttcatc atg aat gct aat aaa      55
                                            Met Asn Ala Asn Lys 
                                            1               5   

gat gaa aga ctt aaa gcc aga agc caa gat ttt cac ctt ttt cct gct     103
Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe His Leu Phe Pro Ala 
                10                  15                  20      

ttg atg atg cta agc atg acc atg ttg ttt ctt cca gtc act ggc act     151
Leu Met Met Leu Ser Met Thr Met Leu Phe Leu Pro Val Thr Gly Thr 
            25                  30                  35          

ttg aag caa aat att cca aga ctc aag cta acc tac aaa gac ttg ctg     199
Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr Tyr Lys Asp Leu Leu 
        40                  45                  50              

ctt tca aat agc tgt att ccc ttt ttg ggt tca tca gaa gga ctg gat     247
Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser Ser Glu Gly Leu Asp 
    55                  60                  65                  

ttt caa act ctt ctc tta gat gag gaa aga ggc agg ctg ctc ttg gga     295
Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly Arg Leu Leu Leu Gly 
70                  75                  80                  85  

gcc aaa gac cac atc ttt cta ctc agt ctg gtt gac tta aac aaa aat     343
Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val Asp Leu Asn Lys Asn 
                90                  95                  100     

ttt aag aag att tat tgg cct gct gca aag gaa cgg gtg gaa tta tgt     391
Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu Arg Val Glu Leu Cys 
            105                 110                 115         

aaa tta aag ggg aaa gat gcc aat aca gaa tgt gca aat ttc atc aga     439
Lys Leu Lys Gly Lys Asp Ala Asn Thr Glu Cys Ala Asn Phe Ile Arg 
        120                 125                 130             

gta ctt cag ccc tat aac aaa act cac ata tat gtg tgt gga act gga     487
Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr Val Cys Gly Thr Gly 
    135                 140                 145                 

gca ttt cat cca ata tgt ggg tat att gat ctt gga gtc tac aag gag     535
Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu Gly Val Tyr Lys Glu 
150                 155                 160                 165 

gat att ata ttc aaa cta gac aca cat aat ttg gag tct ggc aga ctg     583
Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu Glu Ser Gly Arg Leu 
                170                 175                 180     

aaa tgt cct ttc gat cct cag cag cct ttt gct tca gta atg aca gat     631
Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala Ser Val Met Thr Asp 
            185                 190                 195         

gag tac ctc tac tct gga aca gct tct gat ttc ctt ggc aaa gat act     679
Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe Leu Gly Lys Asp Thr 
        200                 205                 210             

gca ttc act cga tcc ctt ggg cct act cat gac cac cac tac atc aga     727
Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp His His Tyr Ile Arg 
    215                 220                 225                 

act gac att tca gag cac tac tgg ctc aat gga gca aaa ttt att gga     775
Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly Ala Lys Phe Ile Gly 
230                 235                 240                 245 

act ttc ttc ata cca gac acc tac aat cca gat gat gat aaa ata tat     823
Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp Asp Asp Lys Ile Tyr 
                250                 255                 260     

ttc ttc ttt cgt gaa tca tct caa gaa ggc agt acc tcc gat aaa acc     871
Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser Thr Ser Asp Lys Thr 
            265                 270                 275         

atc ctt tct cga gtt gga aga gtt tgt aag aat gat gta gga gga caa     919
Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn Asp Val Gly Gly Gln 
        280                 285                 290             

cgc agc ctg ata aac aag tgg acg act ttt ctt aag gcc aga ctg att     967
Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
    295                 300                 305                 

tgc tca att cct gga agt gat ggg gca gat act tac ttt gat gag ctt    1015
Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr Tyr Phe Asp Glu Leu 
310                 315                 320                 325 

caa gat att tat tta ctc ccc aca aga gat gaa aga aat cct gta gta    1063
Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu Arg Asn Pro Val Val 
                330                 335                 340     

tat gga gtc ttt act aca acc agc tcc atc ttc aaa ggc tct gct gtt    1111
Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe Lys Gly Ser Ala Val 
            345                 350                 355         

tgt gtg tat agc atg gct gac atc aga gca gtt ttt aat ggt cca tat    1159
Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val Phe Asn Gly Pro Tyr 
        360                 365                 370             

gct cat aag gaa agt gca gac cat cgt tgg gtg cag tat gat ggg aga    1207
Ala His Lys Glu Ser Ala Asp His Arg Trp Val Gln Tyr Asp Gly Arg 
    375                 380                 385                 

att cct tat cca cgg cct ggt aca tgt cca agc aaa acc tat gac cca    1255
Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Tyr Asp Pro 
390                 395                 400                 405 

ctg att aag tcc acc cga gat ttt cca gat gat gtc atc agt ttc ata    1303
Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp Val Ile Ser Phe Ile 
                410                 415                 420     

aag cgg cac tct gtg atg tat aag tcc gta tac cca gtt gca gga gga    1351
Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr Pro Val Ala Gly Gly 
            425                 430                 435         

cca acg ttc aag aga atc aat gtg gat tac aga ctg aca cag ata gtg    1399
Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg Leu Thr Gln Ile Val 
        440                 445                 450             

gtg gat cat gtc att gca gaa gat ggc cag tac gat gta atg ttt ctt    1447
Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Leu 
    455                 460                 465                 

gga aca gac att gga act gtc ctc aaa gtt gtc agc att tca aag gaa    1495
Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val Ser Ile Ser Lys Glu 
470                 475                 480                 485 

aag tgg aat atg gaa gag gta gtg ctg gag gag ttg cag ata ttc aag    1543
Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu Leu Gln Ile Phe Lys 
                490                 495                 500     

cac tca tca atc atc ttg aac atg gaa ttg tct ctg aag cag caa caa    1591
His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser Leu Lys Gln Gln Gln 
            505                 510                 515         

ttg tac att ggt tcc cga gat gga ttg gtt cag ctc tcc ttg cac aga    1639
Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln Leu Ser Leu His Arg 
        520                 525                 530             

tgc gac act tat ggg aaa gct tgc gca gac tgt tgt ctt gcc aga gac    1687
Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys Cys Leu Ala Arg Asp 
    535                 540                 545                 

ccc tac tgt gcc tgg gat gga aat gca tgc tct cga tat gct cct act    1735
Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser Arg Tyr Ala Pro Thr 
550                 555                 560                 565 

tct aaa agg aga gct aga cgc caa gat gta aaa tat ggc gac cca atc    1783
Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys Tyr Gly Asp Pro Ile 
                570                 575                 580     

acc cag tgc tgg gac atc gaa gac agc att agt cat gaa act gct gat    1831
Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser His Glu Thr Ala Asp 
            585                 590                 595         

gaa aag gtg att ttt ggc att gaa ttt aac tca acc ttt ctg gaa tgt    1879
Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser Thr Phe Leu Glu Cys 
        600                 605                 610             

ata cct aaa tcc caa caa gca act att aaa tgg tat atc cag agg tca    1927
Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp Tyr Ile Gln Arg Ser 
    615                 620                 625                 

ggg gat gag cat cga gag gag ttg aag ccc gat gaa aga atc atc aaa    1975
Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp Glu Arg Ile Ile Lys 
630                 635                 640                 645 

acg gaa tat ggg cta ctg att cga agt ttg cag aag aag gat tct ggg    2023
Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln Lys Lys Asp Ser Gly 
                650                 655                 660     

atg tat tac tgc aaa gcc cag gag cac act ttc atc cac acc ata gtg    2071
Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe Ile His Thr Ile Val 
            665                 670                 675         

aag ctg act ttg aat gtc att gag aat gaa cag atg gaa aat acc cag    2119
Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln Met Glu Asn Thr Gln 
        680                 685                 690             

agg gca gag cat gag gag ggg aag gtc aag gat cta ttg gct gag tca    2167
Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp Leu Leu Ala Glu Ser 
    695                 700                 705                 

cgg ttg aga tac aaa gac tac atc caa atc ctt agc agc cca aac ttc    2215
Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu Ser Ser Pro Asn Phe 
710                 715                 720                 725 

agc ctc gac cag tac tgc gaa cag atg tgg cac agg gag aag cgg aga    2263
Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His Arg Glu Lys Arg Arg 
                730                 735                 740     

cag aga aac aag ggg ggc cca aag tgg aag cac atg cag gaa atg aag    2311
Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His Met Gln Glu Met Lys 
            745                 750                 755         

aag aaa cga aat cga aga cat cac aga gac ctg gat gag ctc cct aga    2359
Lys Lys Arg Asn Arg Arg His His Arg Asp Leu Asp Glu Leu Pro Arg 
        760                 765                 770             

gct gta gcc acg tag ttttctactt aatttaaaga aaagaattcc ttacctataa    2414
Ala Val Ala Thr                                                 
    775                                                         

aaacattgcc ttctgttttg tatatccctt atagtaattc ataaatgctt cccatggagt  2474

tttgctaagg cacaagacaa taatctgaat aagacaatat gtgatgaata taagaaaggg  2534

caaaaaattc atttgaacca gttttccaag aacaaatctt gcacaagcaa agtataagaa  2594

ttatcctaaa aatagggggt ttacagttgt aaatgtttta tgttttgagt tttggaattt  2654

attgtcatgt aaatagttga gctaagcaag ccccgaattt gatagtgtat aaggtgcttt  2714

attccctcga atgtccatta agcatggaat ttaccatgca gttgtgctat gttcttatga  2774

acagatatat cattcctatt gagaaccagc taccttgtgg tagggaataa gaggtcagac  2834

acaaattaag acaactccca ttatcaacag gaactttctc agtgagccat tcactcctgg  2894

agaatggtat aggaatttgg agaggtgcat tatttctttc tggccactgg ggttaaattt  2954

agtgtactac aacattgatt tactgaaggg cactaatgtt tcccccagga tttctattga  3014

ctagtcagga gtaacaggtt cacagagaga agttggtgct tagttatgtg ttttttagag  3074

tatatactaa gctctacagg gacagaatgc ttaataaata ctttaataag atatgggaaa  3134

atattttaat aaaacaagga aaacataatg atgtataatg catcctgatg ggaaggcatg  3194

cagatgggat ttgttagaag acagaaggaa agacagccat aaattctggc tttggggaaa  3254

actcatatcc ccatgaaaag gaagaacaat cacaaataaa gtgagagtaa tgtaatggag  3314

ctcttttcac tagggtataa gtagctgcca atttgtaatt catctgttaa aaaaaatcta  3374

gattataaca aactgctagc aaaatctgag gaaacataaa ttcttctgaa gaatcatagg  3434

aagagtagac attttattta taaccaatga tatttcagta tatattttct ctcttttaaa  3494

aaatatttat catactctgt atattatttc tttttactgc ctttattctc tcctgtatat  3554

tggattttgt gattatattt gagtgaatag gagaaaacaa tatataacac acagagaatt  3614

aagaaaatga catttctggg gagtggggat atatatttgt tgaataacag aacgagtgta  3674

aaattttaac aacggaaagg gttaaattaa ctctttgaca tcttcactca accttttctc  3734

attgctgagt taatctgttg taattgtagt attgtttttg taatttaaca ataaataagc  3794

ctgctacatg taaaaagaac caaactcaca atattaacat aaacatcttt catattttgt  3854

tagtactttc aaatgttttc aatttgactt tccctctgaa tatgcatggt gtgtttcctg  3914

tctgtttaag cagaactcac ctttccttct tgtaacacag aacccttagc cttcttctgt  3974

tttgcctttt cacgcccttt atagtgtgaa atgaaaaatt agtcacttcc tcacatggaa  4034

ggcagctttt cagaaaataa cagacattgc tcgtttctca tgcattctac atatcttgaa  4094

agaaaagtct gtgagaaaac cctgtgatta gagggcaact taatgcaaga tctgtggctc  4154

tatgttgaga gcattctctc tctgttattt ttattttatt tgcattgctt acctatctca  4214

aagtagtcaa actgatatat gagattgagt actccctttt gatattatac tgatgaatat  4274

ttgtaggtgt ttcactataa ggaacagcta aggaataatt ttaataaaag tgaaccagaa  4334

caaatcactc atttaaaaag taattcagaa gaacagtgtg gcatgatcag acttctaatt  4394

gaatagcgta acaacagtgt ttgtaattat agatttgctt ggacaaaata ttccaggaac  4454

tcatagcgag ctcaaagcaa ttaagtggga acatttttaa tttaaaaaaa atttccaaat  4514

atttgtgggt ccgacagtaa tgatcaaaat atgaatgact ttggaaaatt tacatgaagc  4574

tcaagtgtta ggattgactt atgaaaataa attttatttc tatccaaatt tgaatgtcca  4634

aaccattttt tagttacttc tttctaatcc tagttattca gacaaaattt ggaaacttat  4694

tttatgacca catctaatat tctggctgct ttggatacaa tactcttgat ttatgataat  4754

tagttaaaat atattaaaaa tattattagt aaaataaaat ttcacacaat aaaaaacaac  4814

atagagtaca catatttata tgtattttta aagataaaga atatctaaaa tgtgtttttt  4874

tcttagcttt ttagttgtct agaacattta gagaaagagt atgaatatat taaatccaca  4934

aacacactat atacttcctc accactgact attttatcaa atttgcctta aaataatgaa  4994

aaagaaaagt atagttaatg gtttcaaata tgctaagaaa ttgactctgc ggaggggatc  5054

ttaaaatgcc tgtttactca tgttttcgta tttttcttgt ctctaatact tttgtctttg  5114

tctgccttgt gtgttctttt ctgaatttca tttcagcaat ttatgctgct aaatagaatc  5174

ccgcatgtct gcattcattt acattcaact tattgtaaat tttgagattt tatttagaaa  5234

tgaattgtct aattaattta tgtagagtcc ttttttccaa agagctcaaa acactacatc  5294

cacattattg acttttggaa accaaccaaa ttacttaaga aatggaaaag tagtcacaga  5354

gaaatttagt aatttgcaaa agccacaaca gtagtggaag aattaaaatt cataaagtct  5414

catcattctg ttggctaaaa taatgctctt tacaatatgc tggctacaaa atggtcttac  5474

tcttgaattt tgcttttggt tcatattttg gttcttcata ttctagtatg ttttgttcct  5534

gctgaatttt acagactcag ctaaacaata agttattagt agtcacttgt tttcattatc  5594

ataattgaat ttccaagaac aacttgatat cattcagctg tccaaaaaat aataagagca  5654

ttcattaaat actgattttc ttaaacttaa atgttgtatt tcatatttat ttatataata  5714

caaatggaaa tcaaaactga aatagcctcc ctttagaatg tcacattttt cttagaaaac  5774

attttggaat tggttaacct tattgggaat ggataattta gaaacaaacc aaaaaaaaaa  5834

aaagatattt gaagtgtttt tataggagat gtatttttat catagtaaat gatcacaatt  5894

ttaaataatt catcttacaa gtcaggtaaa ataaaatcga ttcccagatt ccatacatta  5954

ggagtgcaaa gacaggatca tacacatgac ttatacctct catttaaata ttttatagta  6014

taaagtattt atggaaaggg tttgagatag atgatttttg ggaaagggca aaatgtgtca  6074

gatgccctag ttaatcatgt aatttaattc tggtattgtg agtggttagc aatcaatttt  6134

gaatttataa ttctgctatt ttaaaagaaa tgtagtcttg tagtatgaaa taattaaaaa  6194

ttgttaaatg tatattttgg ttgtattata ataaaatgca aacatgactg ttctatgatt  6254

ataaaaaaaa aaaaaaaaaa aa                                           6276

<210> 70
<211> 777
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:41..2374 from SEQ ID NO 69

<400> 70
Met Asn Ala Asn Lys Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe 
1               5                   10                  15      
His Leu Phe Pro Ala Leu Met Met Leu Ser Met Thr Met Leu Phe Leu 
            20                  25                  30          
Pro Val Thr Gly Thr Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              
Tyr Lys Asp Leu Leu Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  
Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  
Arg Leu Leu Leu Gly Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val 
                85                  90                  95      
Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         
Arg Val Glu Leu Cys Lys Leu Lys Gly Lys Asp Ala Asn Thr Glu Cys 
        115                 120                 125             
Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr 
    130                 135                 140                 
Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 
Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     
Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         
Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             
Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp 
    210                 215                 220                 
His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly 
225                 230                 235                 240 
Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         
Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             
Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 
Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 
Tyr Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     
Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         
Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             
Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 
Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 
Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     
Val Ile Ser Phe Ile Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         
Pro Val Ala Gly Gly Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             
Leu Thr Gln Ile Val Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 
Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 
Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     
Leu Gln Ile Phe Lys His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         
Leu Lys Gln Gln Gln Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln 
        515                 520                 525             
Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 
Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     
Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         
His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             
Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp 
    610                 615                 620                 
Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 
Glu Arg Ile Ile Lys Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     
Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         
Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             
Met Glu Asn Thr Gln Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp 
    690                 695                 700                 
Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 
Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His 
                725                 730                 735     
Arg Glu Lys Arg Arg Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His 
            740                 745                 750         
Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             
Asp Glu Leu Pro Arg Ala Val Ala Thr 
    770                 775         

<210> 71
<211> 6521
<212> DNA
<213> Artificial Sequence


<220> 
<223> full-length mouse Sema3D A120K

<220> 
<221> CDS
<222> 547..2880
<223> /transl_table=1

<400> 71
aaacccaccc tggacagcgc ggccgagaca gggaaggttt gctcgctctg agggattgcc    60

agcacatcag aagtggccgg gagctggggg aggagactga agggagaggt aatccctggc   120

gttttgagca tccccttttt agaaagaagg agtctctccc aggacagctg ctgcggtcac   180

accacaaact taaaagccgc cctcctgctt ggagcgtgcc tttcctcacc acgctcgctg   240

gcctaagcgc caactggtgg gtcactgtcc gagagagagg cgctgcgctc gggggacagg   300

agcgccccct gccttcccgc ttggccgtag ccgcggcctc attgctctgc cagggccgcc   360

tgtgcggggt tcagccccgg ctgccgctcc gaagaactcg cgcctgtgcc cgcggtcgcc   420

atcctcttgg cttccttggg ctgtcctttc ctctctcctg agcctgcgac gtaaggaaag   480

gaaaagcgac aagagttgct agcaggaagg gtgaactaac agtgtttgaa aaacaaaatt   540

ttcatc atg aat gtt act aaa gat gag aac cca aga tcc aga agt caa      588
       Met Asn Val Thr Lys Asp Glu Asn Pro Arg Ser Arg Ser Gln 
       1               5                   10                  

gat ctt cac ctt ttt cat gct tgg atg atg tta atc atg acg gtg ctc     636
Asp Leu His Leu Phe His Ala Trp Met Met Leu Ile Met Thr Val Leu 
15                  20                  25                  30  

ttt ctt cct gtc act gaa acg tct aaa caa aat att cca aga ctc aag     684
Phe Leu Pro Val Thr Glu Thr Ser Lys Gln Asn Ile Pro Arg Leu Lys 
                35                  40                  45      

cta acc tac aaa gac ttg ctg ctt tca aac acc tgt atc ccc ttt ttg     732
Leu Thr Tyr Lys Asp Leu Leu Leu Ser Asn Thr Cys Ile Pro Phe Leu 
            50                  55                  60          

ggt tca tca gaa gga ttg gat ttc cag act ctt ctt ttg gat gag gag     780
Gly Ser Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu 
        65                  70                  75              

agg ggc ata ctg ctc cta gga gcc aaa gac cat gtc ttc ctg ctc agt     828
Arg Gly Ile Leu Leu Leu Gly Ala Lys Asp His Val Phe Leu Leu Ser 
    80                  85                  90                  

ctg gtt gac ttg aac aag aat ttt aag aag att tat tgg cct gct gca     876
Leu Val Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala 
95                  100                 105                 110 

aaa gaa cga gtg gag cta tgt aaa tta aag ggg aaa gat gcc aat gca     924
Lys Glu Arg Val Glu Leu Cys Lys Leu Lys Gly Lys Asp Ala Asn Ala 
                115                 120                 125     

gaa tgt gca aat ttc atc cgt gtg ctt caa ccc tat aat aag act cac     972
Glu Cys Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His 
            130                 135                 140         

gtt tac gtg tgt gga act gga gcg ttt cat ccg ctg tgt ggg tac att    1020
Val Tyr Val Cys Gly Thr Gly Ala Phe His Pro Leu Cys Gly Tyr Ile 
        145                 150                 155             

gat ctc ggc gcc aac aag gag gaa ctc ata ttt aaa cta gac acg cac    1068
Asp Leu Gly Ala Asn Lys Glu Glu Leu Ile Phe Lys Leu Asp Thr His 
    160                 165                 170                 

aac ctg gag tct ggc aga ctg aaa tgt ccc ttt gat cct cag cag cct    1116
Asn Leu Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro 
175                 180                 185                 190 

ttt gct tca gta atg aca gat gag cac ctc tac tct gga aca gct tct    1164
Phe Ala Ser Val Met Thr Asp Glu His Leu Tyr Ser Gly Thr Ala Ser 
                195                 200                 205     

gat ttc ctt ggc aaa gac act gca ttc aca agg tct ctg ggg cta atg    1212
Asp Phe Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Leu Met 
            210                 215                 220         

cag gac cac cat tcc atc aga act gac att tca gag cac cac tgg ctc    1260
Gln Asp His His Ser Ile Arg Thr Asp Ile Ser Glu His His Trp Leu 
        225                 230                 235             

aat gga gca aaa ttt atc gga aca ttc ccc att cca gac acc tat aat    1308
Asn Gly Ala Lys Phe Ile Gly Thr Phe Pro Ile Pro Asp Thr Tyr Asn 
    240                 245                 250                 

cca gat gat gat aaa ata tat ttc ttc ttt cga gaa tca tcc cag gaa    1356
Pro Asp Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu 
255                 260                 265                 270 

ggc agt act tct gac aga agc att ctt tca aga gtt gga aga gtt tgt    1404
Gly Ser Thr Ser Asp Arg Ser Ile Leu Ser Arg Val Gly Arg Val Cys 
                275                 280                 285     

aag aat gat gta ggt ggg caa cga agt ctg ata aac aaa tgg aca act    1452
Lys Asn Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr 
            290                 295                 300         

ttt cta aag gca aga ctg att tgc tcg att cct gga agc gat ggg gca    1500
Phe Leu Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala 
        305                 310                 315             

gat acc cat ttt gat gaa ctc caa gat att tac tta ctc cct acg aga    1548
Asp Thr His Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg 
    320                 325                 330                 

gat gaa aga aat cct gta gta tat gga gtc ttt acc aca acc agc tcc    1596
Asp Glu Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser 
335                 340                 345                 350 

atc ttc aaa ggc tct gct gtc tgt gtg tac agc atg gct gat atc cga    1644
Ile Phe Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg 
                355                 360                 365     

gca gtc ttt aat ggt ccc tat gct cat aag gaa agt gct gac cat cgc    1692
Ala Val Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg 
            370                 375                 380         

tgg gtg caa tat gat gga agg ata cct tac ccc cga cct gga acg tgt    1740
Trp Val Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys 
        385                 390                 395             

cca agc aaa acc tat gac cca ctg att aag tcc acc cga gac ttt cca    1788
Pro Ser Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro 
    400                 405                 410                 

gac gat gtt atc agt ttc ata agg cgg cac cct gtg atg tat aag tcc    1836
Asp Asp Val Ile Ser Phe Ile Arg Arg His Pro Val Met Tyr Lys Ser 
415                 420                 425                 430 

gtg tac cca gtg gca gga gca ccg acc ttc aag aga atc aac gtg gat    1884
Val Tyr Pro Val Ala Gly Ala Pro Thr Phe Lys Arg Ile Asn Val Asp 
                435                 440                 445     

tac aga ctg acg cag ata gtg gtg gat cac gtg gtc gct gaa gac ggg    1932
Tyr Arg Leu Thr Gln Ile Val Val Asp His Val Val Ala Glu Asp Gly 
            450                 455                 460         

cag tat gat gtc atg ttt ctc gga aca gac att gga aca gtc ctg aaa    1980
Gln Tyr Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys 
        465                 470                 475             

gtt gtg agc atc tcc aag gag aag tgg aat atg gaa gag gtc gta ctg    2028
Val Val Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu 
    480                 485                 490                 

gag gag ctt cag gta ttc aag cac cca aca gct atc ttg aac atg gag    2076
Glu Glu Leu Gln Val Phe Lys His Pro Thr Ala Ile Leu Asn Met Glu 
495                 500                 505                 510 

ttg tcg ctg aag cag caa cag ttg tac gtt ggt tcc tgg gat gga ttg    2124
Leu Ser Leu Lys Gln Gln Gln Leu Tyr Val Gly Ser Trp Asp Gly Leu 
                515                 520                 525     

gtc cag ctc tcc ttg cac aga tgc gac act tac ggg aaa gca tgt gca    2172
Val Gln Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala 
            530                 535                 540         

gac tgc tgt ctc gcc aga gac cct tac tgt gcc tgg gat gga aat gct    2220
Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala 
        545                 550                 555             

tgc tcc aga tat gca ccc acg tct aaa agg cga gct aga cgc cag gat    2268
Cys Ser Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp 
    560                 565                 570                 

gta aaa tat ggg gac cca atc act cag tgc tgg gac ata gaa gac agc    2316
Val Lys Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser 
575                 580                 585                 590 

att agt cat gaa aca gct gat gaa aag gtg att ttt gga att gaa ttt    2364
Ile Ser His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe 
                595                 600                 605     

aat tca acc ttt ttg gag tgt ata cct aaa tcc caa caa gcc tct gtt    2412
Asn Ser Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Ser Val 
            610                 615                 620         

gag tgg tac atc cag cgg tca gga gat gag cat cga gag gag ttg aaa    2460
Glu Trp Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys 
        625                 630                 635             

cct gat gaa agg atc atc aaa act gac tat ggg cta ctg att cga agt    2508
Pro Asp Glu Arg Ile Ile Lys Thr Asp Tyr Gly Leu Leu Ile Arg Ser 
    640                 645                 650                 

ctg cag aag aag gat tct ggg atg tat tac tgc aaa gca cag gag cac    2556
Leu Gln Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His 
655                 660                 665                 670 

act ttc atc cac acc ata gtg aag ctg act ttg aat gtc att gag aat    2604
Thr Phe Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn 
                675                 680                 685     

gaa cag atg gaa aat acc cag agg gca gaa tac cag gag ggg cag gtc    2652
Glu Gln Met Glu Asn Thr Gln Arg Ala Glu Tyr Gln Glu Gly Gln Val 
            690                 695                 700         

aag gat ctg ttg gct gag tca cgg ttg aga tac aaa gac tac atc caa    2700
Lys Asp Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln 
        705                 710                 715             

atc ctt agc agc ccg aac ttc agc ctg gac cag tac tgt gag cag atg    2748
Ile Leu Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met 
    720                 725                 730                 

tgg tac aag gag aag cgg aga cag cgc aac aag ggc agc cca aag tgg    2796
Trp Tyr Lys Glu Lys Arg Arg Gln Arg Asn Lys Gly Ser Pro Lys Trp 
735                 740                 745                 750 

aag cac atg cag gaa atg aag aag aaa cga aat cga cga cat cac aga    2844
Lys His Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg 
                755                 760                 765     

gac ctc gat gag ctc cag aga tca gta gct aca tag ttttctattt         2890
Asp Leu Asp Glu Leu Gln Arg Ser Val Ala Thr                
            770                 775                        

aatttaaaga gggaattatt tacctgcctg cacaaataat gtcttctgtt ttgtacatcc  2950

cttatactaa ctcatacatg cttcccatgg agtctcacgg aggcacagga tgctatgctg  3010

agtaagacta tataggacat catctgaacc agctttccaa gaacaaaatc tgtatcagca  3070

aagttaagaa ttgtcttaaa aataggggcc ttatgtttgt aaatgtctca tagtttgaat  3130

ttaatgtcat gtaaataatc aagttaaatg aacccaggtc cacttagtaa gggcgttatt  3190

cccgtgcatg tccattaagc atggactttc ccatgctgct ggctatgtgc ttaatcattc  3250

cattctagaa caggtgatca tgtaggaact ggagaaaagg cacactttaa aacagcttat  3310

gttagcaaaa aaaaaacttt ctcaaggagc caacaggcca cacttggagt caggcgtggg  3370

aatttagaaa ggcatgttcc ctctttgtgg accaggctac atctagtgta ctgcagtaat  3430

gctctgtgag agggtagtaa tgatcctcac caatttcctt ttgattgctc aagcacagca  3490

tcatggacag aaccccatgg tgtgctctag agtacagaca atggaactta gtacacactt  3550

cctgtgctct ttgggaagca tggtaaaaga tcttaatata ataataaggg tgacatgata  3610

tacactgtat cctaatctgt agatgggaat tatttggaga cagacaagat agctgtaaat  3670

tctgtctctg agaaaaactt atattgccat aaaaaaggag aaagccacaa agtagataga  3730

atgtaatgga attctttcca ctggagtata aatatctgcc aacttataat gttttggtta  3790

aaaataattt agattatagc aaattgttag caaaaatgca agtgaaagta aaatttgtaa  3850

aaaaaattat gggatggcaa tatattattt ataaccaatg tatttctgtg ttctcttttt  3910

ttctaagtat ttatcgtatt ctgtatattg tttgcattta catccttttt tttattatat  3970

ttgagtaaat aggagaaagc aatacgtaat acatagagat aattgagtag atgaccaagg  4030

tggggagtgg ggctatatat ttgttgaatg gatggataat ggcaaaattt tgatgacggg  4090

aagggttaaa ttaactcttc gacatcctct cgttacataa actttcaagc agtgttgttt  4150

tcagcagttt cacaaggaag tcttcaacat ctaaagaaaa cactcacacc gttagcataa  4210

gtaccatttg tattttgcta gcctgtgtca aattcaactt tgcctttgaa cagtgttttc  4270

ctgccagtct ctccagaaat caactttcct tcctgtagca caaaaccctt agccttcctc  4330

tgttttgcct tttcacgctc tttatagtgt gaaatgaaca attagtcact tcctcacaaa  4390

gaatgcagct ttttagaaaa ccaacagacc ttgtttgttt ctcatgcatt ctacatgttt  4450

tgaaagattc tgtgagaagc ctgtgtgatt aaaaagcagt tttacagagt caagcaatct  4510

atctcttcaa agtagcatca gtattttaca ttcatttaat ttgcattggg tacctatctc  4570

aagggcataa cattatctgc aagggactag tataataatg aatatttgtt gatgtttcac  4630

tcttggaaaa agcaaaaatg aaggaacaat tttaatttgt aaaccagaat gaatcacatc  4690

tccagcagaa gtgcatacaa atccttgtgt catggttaga ctactaatca tagatcacac  4750

aataatgttt atctactggc ttactgagtc ctgcaaagtc acagcaaaca tgtcagtggg  4810

tgcatgcttc attcaaaaaa tgctttcaga tagctgtgca tcagagagta atactcaaat  4870

atcagtagta ttgaaagatt gcacaagatt ctactctttg tattgacatc tgaaaattaa  4930

ttttatatag ataataatgt ccaaactatt ttctaattac ttatgtaatt agaaatgtaa  4990

tgttttatca acattctgta aatctatttt acatcttaga tttaaaattt tggctgtttt  5050

gggcataaaa cttctaatta tgattaaata tattataaac attattagga aaatatgatt  5110

ccataataaa ggtagggcta tggtttattt tgaaatgcag actatagcta agcagcattc  5170

attcttattc aaaagactta gaagagtgtt gtgaaagatc agttgacaaa tgtaatgtgt  5230

agttccttac cattgaggat gaacaactct gttttgaaat aataaaaagc agaatattgc  5290

tcaaagttta aatattaaag gtaccagatc ccccagaagc aactctgaac tatgtagtta  5350

ttcatttttt tttaaatcta tttttctgtc ttcagtacaa gtctctagct tctgtgagtg  5410

tttttgctgc atttttattc agtcctttgt gctgctaaat agtagtatgc ctgaatgagt  5470

taatttacat ttaatttatt gggaatttta agagtttgtt tagaaatgga taatctaaat  5530

aagcaattta tgtaaaatcc tttgtttttc tttcccaaaa gagttcataa tcatatatca  5590

cacgacagag taaacatttc agaagaaaca gtcaagttac ttaaaaaact gcaaagtagt  5650

catagaaaaa ctgagcacac tgcagaatcc acaatagctc tcggatgcac aattccagga  5710

tgatttgttt aaagcaagac ttacttacaa catgcctgca atatgatggt cacgcttttg  5770

gacgtttcct ttgtgctata ctttgattct ttgcatatat taattattac atgctattcc  5830

tactgaattg gtgatcttac ctagaggcta acaagagtga ctacttgtta gactaacata  5890

accaagaata atttcccagg acaacttgtg tcatttcatt cacatgaaaa aataaaatta  5950

aacaagacca ctcagtaaac attgattctt cttaaacata tgtctaagat gtattgtaca  6010

tattttactg aaacagaata aagttaactt gggaatccct tctcttcata ataccacatt  6070

gttgcagtca gtgtgtttca actaacaagc cattttgagg gatgggtaac tttttaaaaa  6130

tagaaatgta tattttctca taatagatga tcacaatatt tcaatttaca gtatgtaagg  6190

ttaaaaatac ataagactta aattttccag acttgttaaa ctgaaaatcc atgtacacaa  6250

taaatctcac gctttgtaac tcttgcttaa atcttttgta atgtaaggta tttatgaaaa  6310

tttgaagcat acctttttgg gaaagaaaaa taaaacctgt cagaagccac agttggtctt  6370

cacttcttag cattgtcagt ggtgggtatc aatgaatttg aataatttta cttttaaaaa  6430

actgtagtct tgtagtatag catacttaaa attgttaaat gtatattttg tttgtattat  6490

aataaaacaa gtatcagtgt tctattatta t                                 6521

<210> 72
<211> 777
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:547..2880 from SEQ ID NO 71

<400> 72
Met Asn Val Thr Lys Asp Glu Asn Pro Arg Ser Arg Ser Gln Asp Leu 
1               5                   10                  15      
His Leu Phe His Ala Trp Met Met Leu Ile Met Thr Val Leu Phe Leu 
            20                  25                  30          
Pro Val Thr Glu Thr Ser Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              
Tyr Lys Asp Leu Leu Leu Ser Asn Thr Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  
Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  
Ile Leu Leu Leu Gly Ala Lys Asp His Val Phe Leu Leu Ser Leu Val 
                85                  90                  95      
Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         
Arg Val Glu Leu Cys Lys Leu Lys Gly Lys Asp Ala Asn Ala Glu Cys 
        115                 120                 125             
Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Val Tyr 
    130                 135                 140                 
Val Cys Gly Thr Gly Ala Phe His Pro Leu Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 
Gly Ala Asn Lys Glu Glu Leu Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     
Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         
Ser Val Met Thr Asp Glu His Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             
Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Leu Met Gln Asp 
    210                 215                 220                 
His His Ser Ile Arg Thr Asp Ile Ser Glu His His Trp Leu Asn Gly 
225                 230                 235                 240 
Ala Lys Phe Ile Gly Thr Phe Pro Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         
Thr Ser Asp Arg Ser Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             
Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 
Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 
His Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     
Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         
Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             
Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 
Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 
Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     
Val Ile Ser Phe Ile Arg Arg His Pro Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         
Pro Val Ala Gly Ala Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             
Leu Thr Gln Ile Val Val Asp His Val Val Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 
Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 
Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     
Leu Gln Val Phe Lys His Pro Thr Ala Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         
Leu Lys Gln Gln Gln Leu Tyr Val Gly Ser Trp Asp Gly Leu Val Gln 
        515                 520                 525             
Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 
Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     
Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         
His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             
Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Ser Val Glu Trp 
    610                 615                 620                 
Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 
Glu Arg Ile Ile Lys Thr Asp Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     
Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         
Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             
Met Glu Asn Thr Gln Arg Ala Glu Tyr Gln Glu Gly Gln Val Lys Asp 
    690                 695                 700                 
Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 
Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp Tyr 
                725                 730                 735     
Lys Glu Lys Arg Arg Gln Arg Asn Lys Gly Ser Pro Lys Trp Lys His 
            740                 745                 750         
Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             
Asp Glu Leu Gln Arg Ser Val Ala Thr 
    770                 775         

<210> 73
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid comprised in mutated Semaphorin 3 or functional
      fragment thereof

<220> 
<221> UNSURE
<222> 2
<223> X is K or N

<220> 
<221> UNSURE
<222> 3
<223> X is W, M or L

<220> 
<221> VARIANT
<222> 4
<223> replace/=hydrophilic amino acid

<400> 73
Cys Xaa Xaa Ala Gly Lys Asp 
1               5           

<210> 74
<211> 774
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B deltaIg-b-Fc

<400> 74
Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 
Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
545                 550                 555                 560 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                565                 570                 575     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            580                 585                 590         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        595                 600                 605             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    610                 615                 620                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
625                 630                 635                 640 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                645                 650                 655     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            660                 665                 670         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        675                 680                 685             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    690                 695                 700                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
705                 710                 715                 720 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                725                 730                 735     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            740                 745                 750         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        755                 760                 765             
Ser Leu Ser Pro Gly Lys 
    770                 

<210> 75
<211> 2325
<212> DNA
<213> Homo sapiens


<220> 
<223> SEMA3B deltaIg-b-Fc

<400> 75
atgggcagag ctggcgctgc tgctgtgatt cctggactgg ctctgctgtg ggccgtgggc      60

ctgggatctg ctgctccatc tcccccaaga ctgcggctga gcttccagga actgcaggcc     120

tggcacggac tgcagacctt cagcctggaa cggacatgct gttatcaggc cctgctggtg     180

gacgaggaac ggggcagact gtttgtgggc gccgagaatc atgtggccag cctgaacctg     240

gacaacatca gcaagcgggc caagaagctg gcctggcctg ctcctgtgga atggcgggaa     300

gagtgcaact gggccggcaa ggatatcggc accgagtgca tgaacttcgt gaagctgctg     360

cacgcctaca accggaccca tctgctggcc tgtggaaccg gcgccttcca ccctacctgc     420

gcctttgtgg aagtgggcca cagagccgag gaacccgtgc tgagactgga ccccggcaga     480

atcgaggacg gcaagggcaa gagcccctac gaccctagac atagagccgc cagcgtgctc     540

gtgggagagg aactgtattc tggcgtggcc gccgacctga tgggccggga cttcaccatc     600

ttcagaagcc tgggccagag gcccagcctg agaaccgagc ctcacgactc cagatggctg     660

aacgagccca agttcgtgaa ggtgttctgg attcccgaga gcgagaaccc cgacgacgac     720

aaaatctact tcttcttccg ggaaaccgcc gtggaagccg cccctgctct gggaaggctg     780

tccgtgtcta gagtgggcca gatttgccgg aacgacgtgg gcggacagcg gagcctcgtg     840

aacaagtgga ccaccttcct gaaggccaga ctcgtgtgta gcgtgcccgg cgtggaaggg     900

gacacccact ttgaccagct gcaggacgtg ttcctgctga gcagccggga ccacagaacc     960

cctctgctgt acgccgtgtt cagcaccagc tccagcatct tccagggcag cgccgtgtgc    1020

gtgtacagca tgaacgatgt gcggagagcc ttcctgggcc cctttgccca caaagagggc    1080

cccatgcatc agtgggtgtc ataccagggc agagtgccct accccagacc cggcatgtgt    1140

cccagcaaga ccttcggcac cttcagcagc accaaggact tccccgacga tgtgatccag    1200

ttcgcccgga accaccccct gatgtacaac agcgtgctgc ccactggcgg cagaccactg    1260

tttctgcaag tgggcgccaa ctacaccttt acccagatcg ccgccgacag agtggccgct    1320

gccgatggcc attacgacgt gctgttcatc ggcacagacg tgggcaccgt gctgaaagtg    1380

atcagcgtgc ccaagggcag cagacctagc gccgaaggac tgctgctgga agaactgcac    1440

gtgttcgagg actctgccgc cgtgacctcc atgcagatca gcagcaagag acaccagctg    1500

tacgtggcct ccagatccgc cgtggcccag attgccctgc atagatgtgc cgcccacggc    1560

agagtgtgta ccgagtgttg cctggcccgg gacccttact gtgcttggga tggggtggcc    1620

tgcaccagat tccagcccag cgacaagacc cacacctgtc ccccttgtcc tgcccctgaa    1680

ctgctgggcg gaccctccgt gtttctgttc cccccaaagc ccaaggacac cctgatgatc    1740

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt ctcacgagga ccctgaagtg    1800

aagttcaatt ggtacgtgga cggggtggaa gtgcacaacg ccaagaccaa gcccagagag    1860

gaacagtaca actccaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg    1920

ctgaatggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag    1980

aaaaccatct ccaaggccaa gggccagccc cgcgaacccc aggtgtacac actgccccct    2040

agcagggacg agctgaccaa gaaccaggtg tccctgacct gtctcgtgaa gggcttctac    2100

ccctccgaca ttgccgtgga atgggagagc aatggccagc ccgagaacaa ctacaagacc    2160

accccccctg tgctggacag cgacggctca ttcttcctgt acagcaagct gacagtggac    2220

aagagccggt ggcagcaggg caacgtgttc tcctgcagcg tgatgcacga ggccctgcac    2280

aaccactaca cccagaagtc cctgagcctg agccccggca aatga                    2325


<210> 76
<211> 774
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3B (A105K) deltaIg-b-Fc

<400> 76
Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      
Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          
Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              
Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  
Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  
Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      
Glu Trp Arg Glu Glu Cys Asn Trp Lys Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         
Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             
Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 
Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 
Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     
Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         
Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             
Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 
Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 
Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     
Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         
Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 
Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 
Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly 
                325                 330                 335     
Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         
Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr 
        355                 360                 365             
Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 
Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 
Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly 
                405                 410                 415     
Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln 
            420                 425                 430         
Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             
Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 
Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His 
465                 470                 475                 480 
Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     
Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         
Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu 
        515                 520                 525             
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe 
    530                 535                 540                 
Gln Pro Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
545                 550                 555                 560 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                565                 570                 575     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            580                 585                 590         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        595                 600                 605             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    610                 615                 620                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
625                 630                 635                 640 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                645                 650                 655     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            660                 665                 670         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        675                 680                 685             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    690                 695                 700                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
705                 710                 715                 720 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                725                 730                 735     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            740                 745                 750         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        755                 760                 765             
Ser Leu Ser Pro Gly Lys 
    770                 

<210> 77
<211> 2325
<212> DNA
<213> Homo sapiens


<220> 
<223> SEMA3B (A105K) deltaIg-b-Fc

<400> 77
atgggcagag ctggcgctgc tgctgtgatt cctggactgg ctctgctgtg ggccgtgggc      60

ctgggatctg ctgctccatc tcccccaaga ctgcggctga gcttccagga actgcaggcc     120

tggcacggac tgcagacctt cagcctggaa cggacatgct gttatcaggc cctgctggtg     180

gacgaggaac ggggcagact gtttgtgggc gccgagaatc atgtggccag cctgaacctg     240

gacaacatca gcaagcgggc caagaagctg gcctggcctg ctcctgtgga atggcgggaa     300

gagtgcaact ggaagggcaa ggacatcggc accgagtgca tgaacttcgt gaagctgctg     360

cacgcctaca accggaccca tctgctggcc tgtggaaccg gcgccttcca ccctacctgc     420

gcctttgtgg aagtgggcca cagagccgag gaacccgtgc tgagactgga ccccggcaga     480

atcgaggacg gcaagggcaa gagcccctac gaccctagac atagagccgc cagcgtgctc     540

gtgggagagg aactgtattc tggcgtggcc gccgacctga tgggccggga cttcaccatc     600

ttcagaagcc tgggccagag gcccagcctg agaaccgagc ctcacgactc cagatggctg     660

aacgagccca agttcgtgaa ggtgttctgg attcccgaga gcgagaaccc cgacgacgac     720

aaaatctact tcttcttccg ggaaaccgcc gtggaagccg cccctgctct gggaaggctg     780

tccgtgtcta gagtgggcca gatttgccgg aacgacgtgg gcggacagcg gagcctcgtg     840

aacaagtgga ccaccttcct gaaggccaga ctcgtgtgta gcgtgcccgg cgtggaaggg     900

gacacccact ttgaccagct gcaggacgtg ttcctgctga gcagccggga ccacagaacc     960

cctctgctgt acgccgtgtt cagcaccagc tccagcatct tccagggcag cgccgtgtgc    1020

gtgtacagca tgaacgatgt gcggagagcc ttcctgggcc cctttgccca caaagagggc    1080

cccatgcatc agtgggtgtc ataccagggc agagtgccct accccagacc cggcatgtgt    1140

cccagcaaga ccttcggcac cttcagcagc accaaggact tccccgacga tgtgatccag    1200

ttcgcccgga accaccccct gatgtacaac agcgtgctgc ccactggcgg cagaccactg    1260

tttctgcaag tgggcgccaa ctacaccttt acccagatcg ccgccgacag agtggccgct    1320

gccgatggcc attacgacgt gctgttcatc ggcacagacg tgggcaccgt gctgaaagtg    1380

atcagcgtgc ccaagggcag cagacctagc gccgaaggac tgctgctgga agaactgcac    1440

gtgttcgagg actctgccgc cgtgacctcc atgcagatca gcagcaagag acaccagctg    1500

tacgtggcct ccagatccgc cgtggcccag attgccctgc atagatgtgc cgcccacggc    1560

agagtgtgta ccgagtgttg cctggcccgg gacccttact gtgcttggga tggggtggcc    1620

tgcaccagat tccagcccag cgacaagacc cacacctgtc ccccttgtcc tgcccctgaa    1680

ctgctgggcg gaccctccgt gtttctgttc cccccaaagc ccaaggacac cctgatgatc    1740

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt ctcacgagga ccctgaagtg    1800

aagttcaatt ggtacgtgga cggggtggaa gtgcacaacg ccaagaccaa gcccagagag    1860

gaacagtaca actccaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg    1920

ctgaatggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag    1980

aaaaccatct ccaaggccaa gggccagccc cgcgaacccc aggtgtacac actgccccct    2040

agcagggacg agctgaccaa gaaccaggtg tccctgacct gtctcgtgaa gggcttctac    2100

ccctccgaca ttgccgtgga atgggagagc aatggccagc ccgagaacaa ctacaagacc    2160

accccccctg tgctggacag cgacggctca ttcttcctgt acagcaagct gacagtggac    2220

aagagccggt ggcagcaggg caacgtgttc tcctgcagcg tgatgcacga ggccctgcac    2280

aaccactaca cccagaagtc cctgagcctg agccccggca aatga                    2325


<210> 78
<211> 772
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3C A104K deltaIg-b-Fc

<400> 78
Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      
Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          
Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              
His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  
Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  
Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      
Lys Val Glu Glu Cys Lys Met Lys Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         
Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             
Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 
Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 
Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     
Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         
Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             
Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 
Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 
Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     
Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         
Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             
Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 
Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 
Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     
Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         
Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             
Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 
Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 
Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     
Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         
Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             
Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 
Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 
Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     
Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         
Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             
Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 
Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
545                 550                 555                 560 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                565                 570                 575     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            580                 585                 590         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        595                 600                 605             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    610                 615                 620                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
625                 630                 635                 640 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                645                 650                 655     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            660                 665                 670         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        675                 680                 685             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    690                 695                 700                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
705                 710                 715                 720 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                725                 730                 735     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            740                 745                 750         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        755                 760                 765             
Ser Pro Gly Lys 
    770         

<210> 79
<211> 792
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3D A120K deltaIg-b-Fc

<400> 79
Met Asn Ala Asn Lys Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe 
1               5                   10                  15      
His Leu Phe Pro Ala Leu Met Met Leu Ser Met Thr Met Leu Phe Leu 
            20                  25                  30          
Pro Val Thr Gly Thr Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              
Tyr Lys Asp Leu Leu Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  
Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  
Arg Leu Leu Leu Gly Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val 
                85                  90                  95      
Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         
Arg Val Glu Leu Cys Lys Leu Lys Gly Lys Asp Ala Asn Thr Glu Cys 
        115                 120                 125             
Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr 
    130                 135                 140                 
Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 
Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     
Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         
Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             
Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp 
    210                 215                 220                 
His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly 
225                 230                 235                 240 
Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     
Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         
Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             
Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 
Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 
Tyr Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     
Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         
Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             
Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 
Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 
Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     
Val Ile Ser Phe Ile Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         
Pro Val Ala Gly Gly Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             
Leu Thr Gln Ile Val Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 
Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 
Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     
Leu Gln Ile Phe Lys His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         
Leu Lys Gln Gln Gln Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln 
        515                 520                 525             
Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 
Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 
Arg Tyr Ala Pro Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                565                 570                 575     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            580                 585                 590         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        595                 600                 605             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    610                 615                 620                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
625                 630                 635                 640 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                645                 650                 655     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            660                 665                 670         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        675                 680                 685             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    690                 695                 700                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
705                 710                 715                 720 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                725                 730                 735     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            740                 745                 750         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        755                 760                 765             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    770                 775                 780                 
Ser Leu Ser Leu Ser Pro Gly Lys 
785                 790         

<210> 80
<211> 775
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3E

<400> 80
Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu 
1               5                   10                  15      
Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg 
            20                  25                  30          
Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile 
        35                  40                  45              
Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  
Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  
Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro 
                85                  90                  95      
Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         
Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             
His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe 
    130                 135                 140                 
Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 
Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser 
                165                 170                 175     
Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         
Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Arg 
        195                 200                 205             
Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 
Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 
Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     
Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         
Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 
Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His 
305                 310                 315                 320 
Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     
Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala 
            340                 345                 350         
Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             
Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 
Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 
Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys 
                405                 410                 415     
Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         
Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             
Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 
Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 
Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     
Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         
Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 
Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 
Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     
Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly 
            580                 585                 590         
Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             
Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu 
    610                 615                 620                 
Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 
Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     
Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         
Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu 
        675                 680                 685             
Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln 
    690                 695                 700                 
Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 
Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     
Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         
Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu 
        755                 760                 765             
Pro Arg His Thr Leu Asp Ser 
    770                 775 

<210> 81
<211> 775
<212> PRT
<213> Mus musculus


<220> 
<223> Sema3E

<400> 81
Met Ala Pro Ala Gly His Ile Leu Thr Leu Leu Leu Trp Gly His Leu 
1               5                   10                  15      
Leu Glu Leu Trp Thr Pro Gly His Ser Ala Asn Pro Ser Tyr Pro Arg 
            20                  25                  30          
Leu Arg Leu Ser His Lys Glu Leu Leu Glu Leu Asn Arg Thr Ser Ile 
        35                  40                  45              
Phe Gln Ser Pro Leu Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  
Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  
Leu Asn Leu Glu Arg Val Ser Asp Gly Tyr Arg Glu Ile Tyr Trp Pro 
                85                  90                  95      
Ser Thr Ala Val Lys Val Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         
Asn Glu Cys Ala Asn Tyr Ile Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             
His Leu Leu Thr Cys Ala Thr Gly Ala Phe Asp Pro His Cys Ala Phe 
    130                 135                 140                 
Ile Arg Val Gly His His Ser Glu Glu Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 
His Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Asn Ser 
                165                 170                 175     
Ser Phe Val Ser Thr Leu Val Gly Asn Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         
Ser Asp Tyr Trp Gly Arg Asp Ser Ala Ile Phe Arg Ser Met Gly Lys 
        195                 200                 205             
Leu Gly His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 
Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 
Asp Asn Lys Met Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     
Asn Asn Ala His Thr Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         
Asp Met Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 
Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp Pro 
305                 310                 315                 320 
Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     
Arg Gly His Ala Val Cys Val Tyr His Met Ser Ser Ile Arg Glu Ala 
            340                 345                 350         
Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             
Leu Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 
Lys Val Asn Gly Gly Lys Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 
Ala Ile Arg Phe Ala Arg Met His Pro Leu Met Tyr Gln Pro Ile Lys 
                405                 410                 415     
Pro Val His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         
Leu Arg Gln Leu Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             
Asp Val Leu Phe Ile Gly Thr Asp Thr Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 
Thr Ile Tyr Asn Gln Glu Thr Glu Trp Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 
Glu Leu Gln Ile Phe Lys Asp Pro Ala Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     
Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         
Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 
Ser Arg Tyr Tyr Pro Thr Gly Ala His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 
Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     
Phe Val Gly Asp Ala Leu Asp Arg Thr Glu Glu Arg Leu Ala Tyr Gly 
            580                 585                 590         
Ile Glu Ser Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             
Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Asp Val Arg Lys Glu 
    610                 615                 620                 
Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 
Phe Leu Arg Val Arg Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     
Val Glu His Asn Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         
Val Glu Glu His Lys Val Glu Gly Met Phe His Lys Asp His Glu Glu 
        675                 680                 685             
Glu Arg His His Lys Met Pro Cys Pro Pro Leu Ser Gly Met Ser Gln 
    690                 695                 700                 
Gly Thr Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 
Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     
Lys Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         
Asn Pro Gln Glu Lys Arg Leu Arg Ser Lys Ala Glu His Phe Arg Leu 
        755                 760                 765             
Pro Arg His Thr Leu Leu Ser 
    770                 775 

<210> 82
<211> 785
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3F

<400> 82
Met Leu Val Ala Gly Leu Leu Leu Trp Ala Ser Leu Leu Thr Gly Ala 
1               5                   10                  15      
Trp Pro Ser Phe Pro Thr Gln Asp His Leu Pro Ala Thr Pro Arg Val 
            20                  25                  30          
Arg Leu Ser Phe Lys Glu Leu Lys Ala Thr Gly Thr Ala His Phe Phe 
        35                  40                  45              
Asn Phe Leu Leu Asn Thr Thr Asp Tyr Arg Ile Leu Leu Lys Asp Glu 
    50                  55                  60                  
Asp His Asp Arg Met Tyr Val Gly Ser Lys Asp Tyr Val Leu Ser Leu 
65                  70                  75                  80  
Asp Leu His Asp Ile Asn Arg Glu Pro Leu Ile Ile His Trp Ala Ala 
                85                  90                  95      
Ser Pro Gln Arg Ile Glu Glu Cys Val Leu Ser Gly Lys Asp Val Asn 
            100                 105                 110         
Gly Glu Cys Gly Asn Phe Val Arg Leu Ile Gln Pro Trp Asn Arg Thr 
        115                 120                 125             
His Leu Tyr Val Cys Gly Thr Gly Ala Tyr Asn Pro Met Cys Thr Tyr 
    130                 135                 140                 
Val Asn Arg Gly Arg Arg Ala Gln Ala Thr Pro Trp Thr Gln Thr Gln 
145                 150                 155                 160 
Ala Val Arg Gly Arg Gly Ser Arg Ala Thr Asp Gly Ala Leu Arg Pro 
                165                 170                 175     
Met Pro Thr Ala Pro Arg Gln Asp Tyr Ile Phe Tyr Leu Glu Pro Glu 
            180                 185                 190         
Arg Leu Glu Ser Gly Lys Gly Lys Cys Pro Tyr Asp Pro Lys Leu Asp 
        195                 200                 205             
Thr Ala Ser Ala Leu Ile Asn Glu Glu Leu Tyr Ala Gly Val Tyr Ile 
    210                 215                 220                 
Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Thr Leu Gly Lys Gln 
225                 230                 235                 240 
Thr Ala Met Arg Thr Asp Gln Tyr Asn Ser Arg Trp Leu Asn Asp Pro 
                245                 250                 255     
Ser Phe Ile His Ala Glu Leu Ile Pro Asp Ser Ala Glu Arg Asn Asp 
            260                 265                 270         
Asp Lys Leu Tyr Phe Phe Phe Arg Glu Arg Ser Ala Glu Ala Pro Gln 
        275                 280                 285             
Ser Pro Ala Val Tyr Ala Arg Ile Gly Arg Ile Cys Leu Asn Asp Asp 
    290                 295                 300                 
Gly Gly His Cys Cys Leu Val Asn Lys Trp Ser Thr Phe Leu Lys Ala 
305                 310                 315                 320 
Arg Leu Val Cys Ser Val Pro Gly Glu Asp Gly Ile Glu Thr His Phe 
                325                 330                 335     
Asp Glu Leu Gln Asp Val Phe Val Gln Gln Thr Gln Asp Val Arg Asn 
            340                 345                 350         
Pro Val Ile Tyr Ala Val Phe Thr Ser Ser Gly Ser Val Phe Arg Gly 
        355                 360                 365             
Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Met Val Phe Asn 
    370                 375                 380                 
Gly Pro Phe Ala His Lys Glu Gly Pro Asn Tyr Gln Trp Met Pro Phe 
385                 390                 395                 400 
Ser Gly Lys Met Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Thr 
                405                 410                 415     
Phe Thr Pro Ser Met Lys Ser Thr Lys Asp Tyr Pro Asp Glu Val Ile 
            420                 425                 430         
Asn Phe Met Arg Ser His Pro Leu Met Tyr Gln Ala Val Tyr Pro Leu 
        435                 440                 445             
Gln Arg Arg Pro Leu Val Val Arg Thr Gly Ala Pro Tyr Arg Leu Thr 
    450                 455                 460                 
Thr Ile Ala Val Asp Gln Val Asp Ala Ala Asp Gly Arg Tyr Glu Val 
465                 470                 475                 480 
Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Ile Val Leu 
                485                 490                 495     
Pro Lys Asp Asp Gln Glu Leu Glu Glu Leu Met Leu Glu Glu Val Glu 
            500                 505                 510         
Val Phe Lys Asp Pro Ala Pro Val Lys Thr Met Thr Ile Ser Ser Lys 
        515                 520                 525             
Arg Gln Gln Leu Tyr Val Ala Ser Ala Val Gly Val Thr His Leu Ser 
    530                 535                 540                 
Leu His Arg Cys Gln Ala Tyr Gly Ala Ala Cys Ala Asp Cys Cys Leu 
545                 550                 555                 560 
Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Gln Ala Cys Ser Arg Tyr 
                565                 570                 575     
Thr Ala Ser Ser Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly 
            580                 585                 590         
Asn Pro Ile Arg Gln Cys Arg Gly Phe Asn Ser Asn Ala Asn Lys Asn 
        595                 600                 605             
Ala Val Glu Ser Val Gln Tyr Gly Val Ala Gly Ser Ala Ala Phe Leu 
    610                 615                 620                 
Glu Cys Gln Pro Arg Ser Pro Gln Ala Thr Val Lys Trp Leu Phe Gln 
625                 630                 635                 640 
Arg Asp Pro Gly Asp Arg Arg Arg Glu Ile Arg Ala Glu Asp Arg Phe 
                645                 650                 655     
Leu Arg Thr Glu Gln Gly Leu Leu Leu Arg Ala Leu Gln Leu Ser Asp 
            660                 665                 670         
Arg Gly Leu Tyr Ser Cys Thr Ala Thr Glu Asn Asn Phe Lys His Val 
        675                 680                 685             
Val Thr Arg Val Gln Leu His Val Leu Gly Arg Asp Ala Val His Ala 
    690                 695                 700                 
Ala Leu Phe Pro Pro Leu Ser Met Ser Ala Pro Pro Pro Pro Gly Ala 
705                 710                 715                 720 
Gly Pro Pro Thr Pro Pro Tyr Gln Glu Leu Ala Gln Leu Leu Ala Gln 
                725                 730                 735     
Pro Glu Val Gly Leu Ile His Gln Tyr Cys Gln Gly Tyr Trp Arg His 
            740                 745                 750         
Val Pro Pro Ser Pro Arg Glu Ala Pro Gly Ala Pro Arg Ser Pro Glu 
        755                 760                 765             
Pro Gln Asp Gln Lys Lys Pro Arg Asn Arg Arg His His Pro Pro Asp 
    770                 775                 780                 
Thr 
785 

<210> 83
<211> 754
<212> PRT
<213> Mus musculus


<220> 
<223> Sema3F

<400> 83
Met Leu Val Thr Ala Phe Ile Leu Trp Ala Ser Leu Leu Thr Gly Ala 
1               5                   10                  15      
Trp Pro Ala Thr Pro Ile Gln Asp Gln Leu Pro Ala Thr Pro Arg Val 
            20                  25                  30          
Arg Leu Ser Phe Lys Glu Leu Lys Ala Thr Gly Thr Ala His Phe Phe 
        35                  40                  45              
Asn Phe Leu Leu Asn Thr Thr Asp Tyr Arg Ile Leu Leu Lys Asp Glu 
    50                  55                  60                  
Asp His Asp Arg Met Tyr Val Gly Ser Lys Asp Tyr Val Leu Ser Leu 
65                  70                  75                  80  
Asp Leu His Asp Ile Asn Arg Glu Pro Leu Ile Ile His Trp Ala Ala 
                85                  90                  95      
Ser Pro Gln Arg Ile Glu Glu Cys Ile Leu Ser Gly Lys Asp Gly Asn 
            100                 105                 110         
Gly Glu Cys Gly Asn Phe Val Arg Leu Ile Gln Pro Trp Asn Arg Thr 
        115                 120                 125             
His Leu Tyr Val Cys Gly Thr Gly Ala Tyr Asn Pro Met Cys Thr Tyr 
    130                 135                 140                 
Val Asn Arg Gly Arg Arg Ala Gln Asp Tyr Ile Phe Tyr Leu Glu Pro 
145                 150                 155                 160 
Glu Lys Leu Glu Ser Gly Lys Gly Lys Cys Pro Tyr Asp Pro Lys Leu 
                165                 170                 175     
Asp Thr Ala Ser Ala Leu Ile Asn Glu Glu Leu Tyr Ala Gly Val Tyr 
            180                 185                 190         
Ile Asp Phe Met Gly Thr Asp Ala Ala Ile Phe Arg Thr Leu Gly Lys 
        195                 200                 205             
Gln Thr Ala Met Arg Thr Asp Gln Tyr Asn Ser Arg Trp Leu Asn Asp 
    210                 215                 220                 
Pro Ser Phe Ile His Ala Glu Leu Ile Pro Asp Ser Ala Glu Arg Asn 
225                 230                 235                 240 
Asp Asp Lys Leu Tyr Phe Phe Phe Arg Glu Arg Ser Ala Glu Ala Pro 
                245                 250                 255     
Gln Asn Pro Ala Val Tyr Ala Arg Ile Gly Arg Ile Cys Leu Asn Asp 
            260                 265                 270         
Asp Gly Gly His Cys Cys Leu Val Asn Lys Trp Ser Thr Phe Leu Lys 
        275                 280                 285             
Ala Arg Leu Val Cys Ser Val Pro Gly Glu Asp Gly Ile Glu Thr His 
    290                 295                 300                 
Phe Asp Glu Leu Gln Asp Val Phe Val Gln Gln Thr Gln Asp Val Arg 
305                 310                 315                 320 
Asn Pro Val Ile Tyr Ala Val Phe Thr Ser Ser Gly Ser Val Phe Arg 
                325                 330                 335     
Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Met Val Phe 
            340                 345                 350         
Asn Gly Pro Phe Ala His Lys Glu Gly Pro Asn Tyr Gln Trp Met Pro 
        355                 360                 365             
Phe Ser Gly Lys Met Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly 
    370                 375                 380                 
Thr Phe Thr Pro Ser Met Lys Ser Thr Lys Asp Tyr Pro Asp Glu Val 
385                 390                 395                 400 
Ile Asn Phe Met Arg Thr His Pro Leu Met Tyr Gln Ala Val Tyr Pro 
                405                 410                 415     
Leu Gln Arg Arg Pro Leu Val Val Arg Thr Gly Ala Pro Tyr Arg Leu 
            420                 425                 430         
Thr Thr Val Ala Val Asp Gln Val Asp Ala Ala Asp Gly Arg Tyr Glu 
        435                 440                 445             
Val Leu Phe Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Ile Val 
    450                 455                 460                 
Leu Pro Lys Asp Asp Gln Glu Val Glu Glu Leu Met Leu Glu Glu Val 
465                 470                 475                 480 
Glu Val Phe Lys Glu Pro Ala Pro Val Lys Thr Met Thr Ile Ser Ser 
                485                 490                 495     
Lys Arg Gln Gln Leu Tyr Val Ala Ser Ala Val Gly Val Thr His Leu 
            500                 505                 510         
Ser Leu His Arg Cys Gln Ala Tyr Gly Ala Ala Cys Ala Asp Cys Cys 
        515                 520                 525             
Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Gln Ala Cys Ser Arg 
    530                 535                 540                 
Tyr Thr Ala Ser Ser Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His 
545                 550                 555                 560 
Gly Asn Pro Ile Arg Gln Cys Arg Gly Phe Asn Ser Asn Ala Asn Lys 
                565                 570                 575     
Asn Ala Val Glu Ser Val Gln Tyr Gly Val Ala Gly Ser Ala Ala Phe 
            580                 585                 590         
Leu Glu Cys Gln Pro Arg Ser Pro Gln Ala Thr Val Lys Trp Leu Phe 
        595                 600                 605             
Gln Arg Asp Pro Ser Asp Arg Arg Arg Glu Ile Arg Ala Glu Asp Arg 
    610                 615                 620                 
Phe Leu Arg Thr Glu Gln Gly Leu Leu Leu Arg Ala Leu Gln Leu Gly 
625                 630                 635                 640 
Asp Arg Gly Leu Tyr Ser Cys Thr Ala Thr Glu Asn Asn Phe Lys His 
                645                 650                 655     
Ile Val Thr Arg Val Gln Leu His Val Leu Gly Arg Asp Ala Val His 
            660                 665                 670         
Ala Ala Leu Phe Pro Pro Leu Ala Val Ser Val Pro Pro Pro Pro Gly 
        675                 680                 685             
Thr Gly Pro Pro Thr Pro Pro Tyr Gln Glu Leu Ala Gln Leu Leu Ala 
    690                 695                 700                 
Gln Pro Glu Val Gly Leu Ile His Gln Tyr Cys Gln Gly Tyr Trp Arg 
705                 710                 715                 720 
His Val Pro Pro Arg Pro Arg Glu Ala Pro Gly Ala Leu Arg Pro Pro 
                725                 730                 735     
Glu Leu Gln Asp Gln Lys Lys Pro Arg Asn Arg Arg His His Pro Pro 
            740                 745                 750         
Asp Thr 
        

<210> 84
<211> 782
<212> PRT
<213> Homo sapiens


<220> 
<223> SEMA3G

<400> 84
Met Ala Pro Ser Ala Trp Ala Ile Cys Trp Leu Leu Gly Gly Leu Leu 
1               5                   10                  15      
Leu His Gly Gly Ser Ser Gly Pro Ser Pro Gly Pro Ser Val Pro Arg 
            20                  25                  30          
Leu Arg Leu Ser Tyr Arg Asp Leu Leu Ser Ala Asn Arg Ser Ala Ile 
        35                  40                  45              
Phe Leu Gly Pro Gln Gly Ser Leu Asn Leu Gln Ala Met Tyr Leu Asp 
    50                  55                  60                  
Glu Tyr Arg Asp Arg Leu Phe Leu Gly Gly Leu Asp Ala Leu Tyr Ser 
65                  70                  75                  80  
Leu Arg Leu Asp Gln Ala Trp Pro Asp Pro Arg Glu Val Leu Trp Pro 
                85                  90                  95      
Pro Gln Pro Gly Gln Arg Glu Glu Cys Val Arg Lys Gly Arg Asp Pro 
            100                 105                 110         
Leu Thr Glu Cys Ala Asn Phe Val Arg Val Leu Gln Pro His Asn Arg 
        115                 120                 125             
Thr His Leu Leu Ala Cys Gly Thr Gly Ala Phe Gln Pro Thr Cys Ala 
    130                 135                 140                 
Leu Ile Thr Val Gly His Arg Gly Glu His Val Leu His Leu Glu Pro 
145                 150                 155                 160 
Gly Ser Val Glu Ser Gly Arg Gly Arg Cys Pro His Glu Pro Ser Arg 
                165                 170                 175     
Pro Phe Ala Ser Thr Phe Ile Asp Gly Glu Leu Tyr Thr Gly Leu Thr 
            180                 185                 190         
Ala Asp Phe Leu Gly Arg Glu Ala Met Ile Phe Arg Ser Gly Gly Pro 
        195                 200                 205             
Arg Pro Ala Leu Arg Ser Asp Ser Asp Gln Ser Leu Leu His Asp Pro 
    210                 215                 220                 
Arg Phe Val Met Ala Ala Arg Ile Pro Glu Asn Ser Asp Gln Asp Asn 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Ser Glu Thr Val Pro Ser Pro Asp Gly 
                245                 250                 255     
Gly Ser Asn His Val Thr Val Ser Arg Val Gly Arg Val Cys Val Asn 
            260                 265                 270         
Asp Ala Gly Gly Gln Arg Val Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Pro Gly Gly Ala Glu Thr 
    290                 295                 300                 
His Phe Asp Gln Leu Glu Asp Val Phe Leu Leu Trp Pro Lys Ala Gly 
305                 310                 315                 320 
Lys Ser Leu Glu Val Tyr Ala Leu Phe Ser Thr Val Ser Ala Val Phe 
                325                 330                 335     
Gln Gly Phe Ala Val Cys Val Tyr His Met Ala Asp Ile Trp Glu Val 
            340                 345                 350         
Phe Asn Gly Pro Phe Ala His Arg Asp Gly Pro Gln His Gln Trp Gly 
        355                 360                 365             
Pro Tyr Gly Gly Lys Val Pro Phe Pro Arg Pro Gly Val Cys Pro Ser 
    370                 375                 380                 
Lys Met Thr Ala Gln Pro Gly Arg Pro Phe Gly Ser Thr Lys Asp Tyr 
385                 390                 395                 400 
Pro Asp Glu Val Leu Gln Phe Ala Arg Ala His Pro Leu Met Phe Trp 
                405                 410                 415     
Pro Val Arg Pro Arg His Gly Arg Pro Val Leu Val Lys Thr His Leu 
            420                 425                 430         
Ala Gln Gln Leu His Gln Ile Val Val Asp Arg Val Glu Ala Glu Asp 
        435                 440                 445             
Gly Thr Tyr Asp Val Ile Phe Leu Gly Thr Asp Ser Gly Ser Val Leu 
    450                 455                 460                 
Lys Val Ile Ala Leu Gln Ala Gly Gly Ser Ala Glu Pro Glu Glu Val 
465                 470                 475                 480 
Val Leu Glu Glu Leu Gln Val Phe Lys Val Pro Thr Pro Ile Thr Glu 
                485                 490                 495     
Met Glu Ile Ser Val Lys Arg Gln Met Leu Tyr Val Gly Ser Arg Leu 
            500                 505                 510         
Gly Val Ala Gln Leu Arg Leu His Gln Cys Glu Thr Tyr Gly Thr Ala 
        515                 520                 525             
Cys Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
    530                 535                 540                 
Ala Ser Cys Thr His Tyr Arg Pro Ser Leu Gly Lys Arg Arg Phe Arg 
545                 550                 555                 560 
Arg Gln Asp Ile Arg His Gly Asn Pro Ala Leu Gln Cys Leu Gly Gln 
                565                 570                 575     
Ser Gln Glu Glu Glu Ala Val Gly Leu Val Ala Ala Thr Met Val Tyr 
            580                 585                 590         
Gly Thr Glu His Asn Ser Thr Phe Leu Glu Cys Leu Pro Lys Ser Pro 
        595                 600                 605             
Gln Ala Ala Val Arg Trp Leu Leu Gln Arg Pro Gly Asp Glu Gly Pro 
    610                 615                 620                 
Asp Gln Val Lys Thr Asp Glu Arg Val Leu His Thr Glu Arg Gly Leu 
625                 630                 635                 640 
Leu Phe Arg Arg Leu Ser Arg Phe Asp Ala Gly Thr Tyr Thr Cys Thr 
                645                 650                 655     
Thr Leu Glu His Gly Phe Ser Gln Thr Val Val Arg Leu Ala Leu Val 
            660                 665                 670         
Val Ile Val Ala Ser Gln Leu Asp Asn Leu Phe Pro Pro Glu Pro Lys 
        675                 680                 685             
Pro Glu Glu Pro Pro Ala Arg Gly Gly Leu Ala Ser Thr Pro Pro Lys 
    690                 695                 700                 
Ala Trp Tyr Lys Asp Ile Leu Gln Leu Ile Gly Phe Ala Asn Leu Pro 
705                 710                 715                 720 
Arg Val Asp Glu Tyr Cys Glu Arg Val Trp Cys Arg Gly Thr Thr Glu 
                725                 730                 735     
Cys Ser Gly Cys Phe Arg Ser Arg Ser Arg Gly Lys Gln Ala Arg Gly 
            740                 745                 750         
Lys Ser Trp Ala Gly Leu Glu Leu Gly Lys Lys Met Lys Ser Arg Val 
        755                 760                 765             
His Ala Glu His Asn Arg Thr Pro Arg Glu Val Glu Ala Thr 
    770                 775                 780         

<210> 85
<211> 780
<212> PRT
<213> Mus musculus


<220> 
<223> Sema3G

<400> 85
Met Asp Pro Ser Ala Trp Ala Ile Cys Cys Leu Leu Gly Ser Leu Leu 
1               5                   10                  15      
Phe His Val Gly Ile Pro Ser Pro Gly Pro Ser Pro Ser Val Pro Arg 
            20                  25                  30          
Leu Arg Leu Ser Tyr Arg Asp Leu Leu Ser Thr Asn Arg Ser Ala Ile 
        35                  40                  45              
Phe Leu Gly Pro Arg Gly Ser Leu Asp Leu Gln Val Met Tyr Leu Asp 
    50                  55                  60                  
Glu Tyr Arg Asp Arg Leu Phe Leu Gly Ser Arg Asp Ala Leu Tyr Ser 
65                  70                  75                  80  
Leu Arg Leu Asp Gln Ala Trp Pro Asp Pro Arg Glu Val Leu Trp Leu 
                85                  90                  95      
Pro Gln Pro Gly Gln Lys Val Glu Cys Val Arg Lys Gly Lys Asp Pro 
            100                 105                 110         
Leu Thr Glu Cys Ala Asn Phe Val Arg Val Leu Gln Pro His Asn Arg 
        115                 120                 125             
Thr His Leu Leu Ala Cys Gly Thr Gly Ala Phe Gln Pro Ile Cys Thr 
    130                 135                 140                 
Phe Ile Thr Val Gly His Arg Gly Glu His Val Leu Arg Leu Asp Ala 
145                 150                 155                 160 
Ser Ser Val Glu Asn Gly Arg Gly Arg Cys Pro His Glu Pro Ser Arg 
                165                 170                 175     
Pro Phe Ala Ser Thr Phe Val Gly Gly Glu Leu Tyr Thr Gly Leu Thr 
            180                 185                 190         
Ala Asp Phe Leu Gly Arg Glu Ala Met Ile Phe Arg Ser Gly Gly Pro 
        195                 200                 205             
Arg Pro Ala Leu Arg Ser Asp Ser Asp Gln Ser Leu Leu His Glu Pro 
    210                 215                 220                 
Arg Phe Val Met Ala Ala Arg Ile Pro Asp Asn Ser Asp Arg Asp Asp 
225                 230                 235                 240 
Asp Lys Val Tyr Phe Phe Phe Ser Glu Thr Val Pro Ser Pro Asp Gly 
                245                 250                 255     
Gly Pro Gly His Val Thr Ile Ser Arg Val Gly Arg Val Cys Val Asn 
            260                 265                 270         
Asp Ala Gly Gly Gln Arg Val Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Pro Gly Gly Ala Glu Thr 
    290                 295                 300                 
His Phe Asp Gln Leu Glu Asp Val Phe Leu Leu Trp Pro Lys Ala Gly 
305                 310                 315                 320 
Lys Ser Leu Glu Val Tyr Ala Leu Phe Ser Thr Val Ser Ala Val Phe 
                325                 330                 335     
Gln Gly Phe Ala Val Cys Val Tyr His Met Val Asp Ile Trp Glu Val 
            340                 345                 350         
Phe Asn Gly Pro Phe Ala His Arg Asp Gly Pro Gln His Gln Trp Gly 
        355                 360                 365             
Pro Tyr Gly Gly Lys Val Pro Phe Pro Arg Pro Gly Val Cys Pro Ser 
    370                 375                 380                 
Lys Met Thr Ala Gln Pro Gly Arg Pro Phe Gly Ser Thr Lys Asp Tyr 
385                 390                 395                 400 
Pro Asp Glu Val Leu Gln Phe Val Arg Asp His Pro Leu Met Phe Gln 
                405                 410                 415     
Pro Val Arg Pro Arg Arg Gly Arg Pro Val Leu Val Lys Thr His Leu 
            420                 425                 430         
Ala Gln Arg Leu Arg Gln Ile Val Val Asp Arg Val Glu Ala Glu Asp 
        435                 440                 445             
Gly Thr Tyr Asp Val Ile Phe Leu Gly Thr Asp Ser Gly Ser Val Leu 
    450                 455                 460                 
Lys Val Ile Ala Leu Gln Gly Gly Gly Leu Thr Glu Pro Glu Glu Val 
465                 470                 475                 480 
Val Leu Glu Glu Leu Gln Val Phe Lys Val Pro Thr Pro Ile Thr Glu 
                485                 490                 495     
Met Glu Ile Ser Val Lys Arg Gln Thr Leu Tyr Val Gly Ser Pro Leu 
            500                 505                 510         
Gly Val Ala Arg Leu Gln Leu His Gln Cys Glu Thr Tyr Gly Ser Ala 
        515                 520                 525             
Cys Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly 
    530                 535                 540                 
Thr Ala Cys Ala Arg Tyr Arg Pro Ser Ser Gly Lys Arg Arg Phe Arg 
545                 550                 555                 560 
Arg Gln Asp Ile Arg His Gly Asn Pro Ala Val Gln Cys Leu Gly Gln 
                565                 570                 575     
Gly Gln Ser Gln Asn Lys Ala Ala Ser Gly Leu Met Thr Arg Val Phe 
            580                 585                 590         
Gly Thr Glu His Asn Ser Thr Phe Leu Glu Cys Leu Pro Lys Ser Pro 
        595                 600                 605             
Gln Ala Ala Val Arg Trp Phe Leu Gln Arg Pro Gly Asp Lys Gly Thr 
    610                 615                 620                 
Asp Gln Val Lys Thr Asp Glu Arg Val Val Gln Thr Ala Gln Gly Leu 
625                 630                 635                 640 
Leu Phe Arg Arg Leu Ser Arg His Asp Ala Gly Asn Tyr Thr Cys Thr 
                645                 650                 655     
Thr Leu Glu His Gly Phe Ser Gln Thr Val Val Arg Phe Ala Leu Glu 
            660                 665                 670         
Val Ile Ala Ala Val Gln Leu Asp Ser Leu Phe Leu Arg Glu Ser Arg 
        675                 680                 685             
Leu Glu Glu Pro Ser Ala Trp Gly Ser Leu Ala Ser Ala Ser Pro Lys 
    690                 695                 700                 
Thr Trp Tyr Lys Asp Ile Leu Gln Leu Thr Gly Phe Ala Asn Leu Pro 
705                 710                 715                 720 
Arg Val Asp Glu Tyr Cys Glu Arg Val Trp Cys Arg Gly Val Gly Glu 
                725                 730                 735     
Arg Ser Gly Ser Phe Arg Gly Lys Gly Lys Gln Ala Lys Gly Lys Ser 
            740                 745                 750         
Trp Ala Gly Leu Glu Leu Gly Lys Lys Met Lys Ser Arg Val Leu Ala 
        755                 760                 765             
Glu His Asn Arg Thr Pro Arg Glu Val Glu Ala Thr 
    770                 775                 780 

