                         SEQUENCE LISTING

<110>  FIBRIANT B.V.
 
<120>  Therapeutic uses of fibrinogen gamma prime variants

<130>  670WO

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  human

<400>  1

Asn Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala 
1               5                   10                  15      


Lys Gln Ala Gly Asp Val 
            20          


<210>  2
<211>  20
<212>  PRT
<213>  human

<400>  2

Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr Pro 
1               5                   10                  15      


Glu Asp Asp Leu 
            20  


<210>  3
<211>  38
<212>  PRT
<213>  human

<400>  3

Asn Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala 
1               5                   10                  15      


Lys Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu 
            20                  25                  30          


Tyr Pro Glu Asp Asp Leu 
        35              


<210>  4
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 
1               5                   10                  15      


Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys Asp Ser Asp 
            20                  25                  30          


Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys Pro Ser Gly 
        35                  40                  45              


Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp Phe Thr Asn 
    50                  55                  60                  


Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln Lys Asn Asn 
65                  70                  75                  80  


Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile Leu Arg Gly 
                85                  90                  95      


Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn Arg Val Ser 
            100                 105                 110         


Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys Val Ile Glu 
        115                 120                 125             


Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg Ala Gln Leu 
    130                 135                 140                 


Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys Ile Arg Ser 
145                 150                 155                 160 


Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys 
                165                 170                 175     


Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile Ala Lys Asp 
            180                 185                 190         


Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile Lys Met Lys 
        195                 200                 205             


Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln Leu Gln Lys 
    210                 215                 220                 


Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln Met Arg Met 
225                 230                 235                 240 


Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly Gly Ser Thr 
                245                 250                 255     


Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn Pro Ser Ser 
            260                 265                 270         


Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser Thr Gly Asn 
        275                 280                 285             


Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr Trp Lys Pro 
    290                 295                 300                 


Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser Gly Ser Ser 
305                 310                 315                 320 


Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro Arg Pro Gly 
                325                 330                 335     


Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly Ser Ala Gly 
            340                 345                 350         


His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly Gln Trp His 
        355                 360                 365             


Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser Gly Asn Ala 
    370                 375                 380                 


Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val Ser Gly Asn 
385                 390                 395                 400 


Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu Val Thr 
                405                 410                 415     


Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys Val Thr Ser 
            420                 425                 430         


Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr Val Thr Lys 
        435                 440                 445             


Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys Glu Val Val 
    450                 455                 460                 


Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp Leu Gly Thr 
465                 470                 475                 480 


Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp 
                485                 490                 495     


Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr Phe Pro Gly 
            500                 505                 510         


Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr Glu Ser Arg 
        515                 520                 525             


Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser Ser Ser His 
    530                 535                 540                 


His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser Ser Ser Tyr 
545                 550                 555                 560 


Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr 
                565                 570                 575     


Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly Ser Glu Ala 
            580                 585                 590         


Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala Lys Ser Arg 
        595                 600                 605             


Pro Val 
    610 


<210>  5
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Gly Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His 
1               5                   10                  15      


Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala 
            20                  25                  30          


Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala 
        35                  40                  45              


Ala Ala Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly 
    50                  55                  60                  


Cys Leu His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys 
65                  70                  75                  80  


Gln Leu Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser 
                85                  90                  95      


Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser 
            100                 105                 110         


Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg 
        115                 120                 125             


Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser 
    130                 135                 140                 


Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn 
145                 150                 155                 160 


Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg 
                165                 170                 175     


Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr 
            180                 185                 190         


Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly 
        195                 200                 205             


Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met 
    210                 215                 220                 


Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys 
225                 230                 235                 240 


Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln 
                245                 250                 255     


Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly 
            260                 265                 270         


Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu 
        275                 280                 285             


Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg 
    290                 295                 300                 


Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp 
305                 310                 315                 320 


Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn 
                325                 330                 335     


Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala 
            340                 345                 350         


Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr 
        355                 360                 365             


Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly 
    370                 375                 380                 


Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly 
385                 390                 395                 400 


Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr 
                405                 410                 415     


Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp 
            420                 425                 430         


Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg 
        435                 440                 445             


Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
    450                 455                 460     


<210>  6
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Val Ala Thr Arg Asp Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly 
1               5                   10                  15      


Ser Tyr Cys Pro Thr Thr Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr 
            20                  25                  30          


Gln Thr Lys Val Asp Lys Asp Leu Gln Ser Leu Glu Asp Ile Leu His 
        35                  40                  45              


Gln Val Glu Asn Lys Thr Ser Glu Val Lys Gln Leu Ile Lys Ala Ile 
    50                  55                  60                  


Gln Leu Thr Tyr Asn Pro Asp Glu Ser Ser Lys Pro Asn Met Ile Asp 
65                  70                  75                  80  


Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile Met Lys Tyr 
                85                  90                  95      


Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu 
            100                 105                 110         


Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val 
        115                 120                 125             


Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln 
    130                 135                 140                 


Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly 
145                 150                 155                 160 


Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln 
                165                 170                 175     


Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr 
            180                 185                 190         


Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys Lys Asn Trp 
        195                 200                 205             


Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr Gly Thr Thr 
    210                 215                 220                 


Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser Thr Gln Ser 
225                 230                 235                 240 


Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp Asn Gly Arg 
                245                 250                 255     


Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro Glu Ala Asp 
            260                 265                 270         


Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp 
        275                 280                 285             


Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe 
    290                 295                 300                 


Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp 
305                 310                 315                 320 


Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly Trp Trp Met 
                325                 330                 335     


Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr Gln Gly Gly 
            340                 345                 350         


Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile 
        355                 360                 365             


Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys Thr Thr Met 
    370                 375                 380                 


Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly Gln Gln His 
385                 390                 395                 400 


His Leu Gly Gly Ala Lys Gln Ala Gly Asp Val 
                405                 410     


<210>  7
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Val Ala Thr Arg Asp Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly 
1               5                   10                  15      


Ser Tyr Cys Pro Thr Thr Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr 
            20                  25                  30          


Gln Thr Lys Val Asp Lys Asp Leu Gln Ser Leu Glu Asp Ile Leu His 
        35                  40                  45              


Gln Val Glu Asn Lys Thr Ser Glu Val Lys Gln Leu Ile Lys Ala Ile 
    50                  55                  60                  


Gln Leu Thr Tyr Asn Pro Asp Glu Ser Ser Lys Pro Asn Met Ile Asp 
65                  70                  75                  80  


Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile Met Lys Tyr 
                85                  90                  95      


Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu 
            100                 105                 110         


Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val 
        115                 120                 125             


Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln 
    130                 135                 140                 


Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly 
145                 150                 155                 160 


Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln 
                165                 170                 175     


Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr 
            180                 185                 190         


Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys Lys Asn Trp 
        195                 200                 205             


Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr Gly Thr Thr 
    210                 215                 220                 


Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser Thr Gln Ser 
225                 230                 235                 240 


Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp Asn Gly Arg 
                245                 250                 255     


Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro Glu Ala Asp 
            260                 265                 270         


Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp 
        275                 280                 285             


Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe 
    290                 295                 300                 


Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp 
305                 310                 315                 320 


Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly Trp Trp Met 
                325                 330                 335     


Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr Gln Gly Gly 
            340                 345                 350         


Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile 
        355                 360                 365             


Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys Thr Thr Met 
    370                 375                 380                 


Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly Gln Gln His 
385                 390                 395                 400 


His Leu Gly Gly Ala Lys Gln Val Arg Pro Glu His Pro Ala Glu Thr 
                405                 410                 415     


Glu Tyr Asp Ser Leu Tyr Pro Glu Asp Asp Leu 
            420                 425         


