                         SEQUENCE LISTING

<110>  National Research Council of Canada
 
<120>  BLOOD-BRAIN BARRIER TRANSMIGRATING THERAPEUTIC COMPOUNDS AND USES
        THEREOF

<130>  P4314PC00

<150>  US 62/661,869
<151>  2018-04-24

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  1

Gly Phe Lys Ile Thr His Tyr Thr Met Gly 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be D or K

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be N or D

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa can be F, I or L

<400>  2

Arg Ile Thr Trp Gly Gly Xaa Xaa Thr Xaa Tyr Ser Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be T or K

<400>  3

Gly Ser Thr Ser Thr Ala Xaa Pro Leu Arg Val Asp Tyr 
1               5                   10              


<210>  4
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  4

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val 
        115                 120 


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be D or E

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa can be F or V

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Xaa can be E or G

<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Xaa can be R or L

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Xaa can be F or W

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Xaa can be L or V

<400>  5

Xaa Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  6

Glu Tyr Pro Ser Asn Phe Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  7

Val Ser Arg Asp Gly Leu Thr Thr 
1               5               


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  8

Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
1               5                   10                  15      


Ser Tyr His Tyr 
            20  


<210>  9
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be E or Q

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be K or Q

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be V or E

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa can be A or P

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa can be V or A

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa can be F or V

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Xaa can be E or G

<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Xaa can be R or L

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Xaa can be F or W

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Xaa can be A or S

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Xaa can be M or I

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Xaa can be A or S

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Xaa can be V or L

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Xaa can be D or Y

<220>
<221>  VARIANT
<222>  (86)..(86)
<223>  Xaa can be V or L

<220>
<221>  VARIANT
<222>  (87)..(87)
<223>  Xaa can be K or R

<220>
<221>  VARIANT
<222>  (122)..(122)
<223>  Xaa can be Q or L

<400>  9

Xaa Val Xaa Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Xaa Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Xaa Ser Arg Asp Asn Xaa Lys Asn Thr Xaa Xaa 
65                  70                  75                  80  


Leu Gln Met Asn Ser Xaa Xaa Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 125         


<210>  10
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  11

Gly Arg Thr Ile Asp Asn Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be A or T

<400>  12

Ile Asp Trp Gly Asp Gly Gly Xaa 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  13

Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be E or Q

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be K or Q

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be V or E

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa can be A or P

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa can be V or S

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Xaa can be D or G

<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Xaa can be L or R

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Xaa can be F or W

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Xaa can be A or S

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Xaa can be A or T

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Xaa can be A or S

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Xaa can be G or N

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Xaa can be M or L

<220>
<221>  VARIANT
<222>  (85)..(85)
<223>  Xaa can be N or R

<220>
<221>  VARIANT
<222>  (87)..(87)
<223>  Xaa can be E or R

<220>
<221>  VARIANT
<222>  (88)..(88)
<223>  Xaa can be P or A

<220>
<221>  VARIANT
<222>  (95)..(95)
<223>  Xaa can be S or Y

<220>
<221>  VARIANT
<222>  (119)..(119)
<223>  Xaa can be Q or L

<400>  14

Xaa Val Xaa Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Xaa Thr Ile Asp Trp Gly Asp Gly Gly Xaa Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Xaa Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Xaa Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Xaa Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  16

Gly Arg Thr Phe Ile Ala Tyr Ala 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  17

Ile Thr Asn Phe Ala Gly Gly Thr Thr 
1               5                   


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  18

Ala Ala Asp Arg Ser Ala Gln Thr Met Arg Gln Val Arg Pro Val Leu 
1               5                   10                  15      


Pro Tyr 
        


<210>  19
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ile Ala Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Asn Phe Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Arg Ser Ala Gln Thr Met Arg Gln Val Arg Pro Val 
            100                 105                 110         


Leu Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  20

Gly Ser Thr Phe Ser Ser Ser Ser 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  21

Ile Thr Ser Gly Gly Ser Thr 
1               5           


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  22

Asn Val Ala Gly Arg Asn Trp Val Pro Ile Ser Arg Tyr Ser Pro Gly 
1               5                   10                  15      


Pro Tyr 
        


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  23

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Ser 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Thr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Arg Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Ala Gly Arg Asn Trp Val Pro Ile Ser Arg Tyr Ser Pro Gly Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  24

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  25
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  25

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His His His 
        515                 520                 525             


His His His His His Trp Ser His Pro Gln Phe Glu Lys 
    530                 535                 540     


<210>  26
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  26

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


Leu Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Asn Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  27
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  27

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


Leu Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Asn Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln His His His His His His His His 
            500                 505 


<210>  28
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  28

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Pro Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  29
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  29

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu Ile 
    130                 135                 140                 


Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu 
145                 150                 155                 160 


Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu Phe 
                165                 170                 175     


Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val Ser 
            180                 185                 190         


Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn 
        195                 200                 205             


Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr 
    210                 215                 220                 


Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe His 
225                 230                 235                 240 


Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp Ser 
                245                 250                 255     


Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr 
            260                 265                 270         


Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro Val 
        275                 280                 285             


Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr 
    290                 295                 300                 


Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser Pro 
305                 310                 315                 320 


Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg Tyr 
                325                 330                 335     


Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala 
            340                 345                 350         


Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro 
        355                 360                 365             


Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile Ser 
    370                 375                 380                 


Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg Gln 
385                 390                 395                 400 


Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu 
                405                 410                 415     


Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala 
            420                 425                 430         


Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp Ala 
        435                 440                 445             


Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe Tyr 
    450                 455                 460                 


Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe 
465                 470                 475                 480 


Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro Gly 
                485                 490                 495     


Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr Leu 
            500                 505                 510         


Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro Ser 
        515                 520                 525             


Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His Phe 
    530                 535                 540                 


Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg 
545                 550                 555                 560 


Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln 
                565                 570                 575     


Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr 
            580                 585                 590         


Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn 
        595                 600                 605             


Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu Leu 
    610                 615                 620                 


Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn Asp 
625                 630                 635                 640 


Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His His His His 
                645                 650                 655     


His His His His Trp Ser His Pro Gln Phe Glu Lys 
            660                 665             


<210>  30
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr 
145                 150                 155                 160 


Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
                165                 170                 175     


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            180                 185                 190         


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        195                 200                 205             


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    210                 215                 220                 


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
225                 230                 235                 240 


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                245                 250                 255     


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            260                 265                 270         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        275                 280                 285             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    290                 295                 300                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
305                 310                 315                 320 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                325                 330                 335     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            340                 345                 350         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        355                 360                 365             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    370                 375                 380                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
385                 390                 395                 400 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                405                 410                 415     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            420                 425                 430         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        435                 440                 445             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    450                 455                 460                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
465                 470                 475                 480 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                485                 490                 495     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            500                 505                 510         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        515                 520                 525             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    530                 535                 540                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
545                 550                 555                 560 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                565                 570                 575     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            580                 585                 590         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        595                 600                 605             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    610                 615                 620                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
625                 630                 635                 640 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                645                 650                 655     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            660                 665                 670         


Gln Leu Leu Met Pro His His His His His His His His Trp Ser His 
        675                 680                 685             


Pro Gln Phe Glu Lys 
    690             


<210>  31
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala 
145                 150                 155                 160 


Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly 
                165                 170                 175     


Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala 
            180                 185                 190         


Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys 
        195                 200                 205             


Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr 
    210                 215                 220                 


Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe 
225                 230                 235                 240 


Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser 
                245                 250                 255     


Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp 
            260                 265                 270         


Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys 
        275                 280                 285             


Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala 
    290                 295                 300                 


Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu 
305                 310                 315                 320 


Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met 
                325                 330                 335     


Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro 
            340                 345                 350         


His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu 
        355                 360                 365             


Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro 
    370                 375                 380                 


Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val 
385                 390                 395                 400 


Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe 
                405                 410                 415     


Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp 
            420                 425                 430         


Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala 
        435                 440                 445             


Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly 
    450                 455                 460                 


Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His 
465                 470                 475                 480 


Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu 
                485                 490                 495     


Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser 
            500                 505                 510         


Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val 
        515                 520                 525             


Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro 
    530                 535                 540                 


Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys 
545                 550                 555                 560 


Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr 
                565                 570                 575     


Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg 
            580                 585                 590         


Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp 
        595                 600                 605             


Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr 
    610                 615                 620                 


Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp 
625                 630                 635                 640 


Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp 
                645                 650                 655     


His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu 
            660                 665                 670         


Met Pro His His His His His His His His Trp Ser His Pro Gln Phe 
        675                 680                 685             


Glu Lys 
    690 


<210>  32
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Pro Cys Ile Pro Lys Ser 
145                 150                 155                 160 


Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp 
                165                 170                 175     


Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr 
            180                 185                 190         


Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile 
        195                 200                 205             


Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu 
    210                 215                 220                 


Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala 
225                 230                 235                 240 


Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu 
                245                 250                 255     


Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg 
            260                 265                 270         


Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala 
        275                 280                 285             


Asp Thr Pro Asp Asp Phe Gln Leu Leu Asn Phe Ser Leu Pro Glu Glu 
    290                 295                 300                 


Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala 
305                 310                 315                 320 


Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp 
                325                 330                 335     


Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln 
            340                 345                 350         


Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe 
        355                 360                 365             


Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala 
    370                 375                 380                 


Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys 
385                 390                 395                 400 


Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu 
                405                 410                 415     


Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met 
            420                 425                 430         


Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu 
        435                 440                 445             


Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp 
    450                 455                 460                 


Tyr Leu Asp Phe Leu Ala Pro Ala Asn Ala Thr Leu Gly Glu Thr His 
465                 470                 475                 480 


Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly 
                485                 490                 495     


Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly 
            500                 505                 510         


Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val 
        515                 520                 525             


Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn 
    530                 535                 540                 


Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys 
545                 550                 555                 560 


Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser 
                565                 570                 575     


Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln 
            580                 585                 590         


Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala 
        595                 600                 605             


Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile 
    610                 615                 620                 


Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser 
625                 630                 635                 640 


Ile His Thr Tyr Leu Trp Arg Arg Gln His His His His His His His 
                645                 650                 655     


His 
    


<210>  33
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  33

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
545                 550                 555                 560 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                565                 570                 575     


Arg Thr Phe Ile Ala Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
            580                 585                 590         


Lys Glu Arg Glu Phe Val Ala Ala Ile Thr Asn Phe Ala Gly Gly Thr 
        595                 600                 605             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    610                 615                 620                 


Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
625                 630                 635                 640 


Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Asp Arg Ser Ala Gln Thr Met 
                645                 650                 655     


Arg Gln Val Arg Pro Val Leu Pro Tyr Trp Gly Gln Gly Thr Gln Val 
            660                 665                 670         


Thr Val Ser His His His His His His His His 
        675                 680             


<210>  34
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  34

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
545                 550                 555                 560 


Leu Val Gln Ala Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                565                 570                 575     


Ser Thr Phe Ser Ser Ser Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly 
            580                 585                 590         


Gln Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn 
        595                 600                 605             


Thr Ala Asp Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala 
    610                 615                 620                 


Lys Asn Thr Val Tyr Leu Gln Met Arg Asp Leu Lys Pro Glu Asp Thr 
625                 630                 635                 640 


Ala Val Tyr Tyr Cys Asn Val Ala Gly Arg Asn Trp Val Pro Ile Ser 
                645                 650                 655     


Arg Tyr Ser Pro Gly Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            660                 665                 670         


Ser Ser His His His His His His His His 
        675                 680         


<210>  35
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr 
145                 150                 155                 160 


Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
                165                 170                 175     


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            180                 185                 190         


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        195                 200                 205             


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    210                 215                 220                 


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
225                 230                 235                 240 


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                245                 250                 255     


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            260                 265                 270         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        275                 280                 285             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    290                 295                 300                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
305                 310                 315                 320 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                325                 330                 335     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            340                 345                 350         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        355                 360                 365             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    370                 375                 380                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
385                 390                 395                 400 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                405                 410                 415     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            420                 425                 430         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        435                 440                 445             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    450                 455                 460                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
465                 470                 475                 480 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                485                 490                 495     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            500                 505                 510         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        515                 520                 525             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    530                 535                 540                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
545                 550                 555                 560 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                565                 570                 575     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            580                 585                 590         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        595                 600                 605             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    610                 615                 620                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
625                 630                 635                 640 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                645                 650                 655     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            660                 665                 670         


Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu 
        675                 680                 685             


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
    690                 695                 700                 


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
705                 710                 715                 720 


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
                725                 730                 735     


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
            740                 745                 750         


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
        755                 760                 765             


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
    770                 775                 780                 


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
785                 790                 795                 800 


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
                805                 810                 815     


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
            820                 825                 830         


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
        835                 840                 845             


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
    850                 855                 860                 


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
865                 870                 875                 880 


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
                885                 890                 895     


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
            900                 905                 910         


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
        915                 920                 925             


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
    930                 935                 940                 


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
945                 950                 955                 960 


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
                965                 970                 975     


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
            980                 985                 990         


Glu Ser Lys Asp Val Cys Lys Asn  Tyr Ala Glu Ala Lys  Asp Val Phe 
        995                 1000                 1005             


Leu Gly  Met Phe Leu Tyr Glu  Tyr Ala Arg Arg His  Pro Asp Tyr 
    1010                 1015                 1020             


Ser Val  Val Leu Leu Leu Arg  Leu Ala Lys Thr Tyr  Glu Thr Thr 
    1025                 1030                 1035             


Leu Glu  Lys Cys Cys Ala Ala  Ala Asp Pro His Glu  Cys Tyr Ala 
    1040                 1045                 1050             


Lys Val  Phe Asp Glu Phe Lys  Pro Leu Val Glu Glu  Pro Gln Asn 
    1055                 1060                 1065             


Leu Ile  Lys Gln Asn Cys Glu  Leu Phe Glu Gln Leu  Gly Glu Tyr 
    1070                 1075                 1080             


Lys Phe  Gln Asn Ala Leu Leu  Val Arg Tyr Thr Lys  Lys Val Pro 
    1085                 1090                 1095             


Gln Val  Ser Thr Pro Thr Leu  Val Glu Val Ser Arg  Asn Leu Gly 
    1100                 1105                 1110             


Lys Val  Gly Ser Lys Cys Cys  Lys His Pro Glu Ala  Lys Arg Met 
    1115                 1120                 1125             


Pro Cys  Ala Glu Asp Tyr Leu  Ser Val Val Leu Asn  Gln Leu Cys 
    1130                 1135                 1140             


Val Leu  His Glu Lys Thr Pro  Val Ser Asp Arg Val  Thr Lys Cys 
    1145                 1150                 1155             


Cys Thr  Glu Ser Leu Val Asn  Arg Arg Pro Cys Phe  Ser Ala Leu 
    1160                 1165                 1170             


Glu Val  Asp Glu Thr Tyr Val  Pro Lys Glu Phe Asn  Ala Glu Thr 
    1175                 1180                 1185             


Phe Thr  Phe His Ala Asp Ile  Cys Thr Leu Ser Glu  Lys Glu Arg 
    1190                 1195                 1200             


Gln Ile  Lys Lys Gln Thr Ala  Leu Val Glu Leu Val  Lys His Lys 
    1205                 1210                 1215             


Pro Lys  Ala Thr Lys Glu Gln  Leu Lys Ala Val Met  Asp Asp Phe 
    1220                 1225                 1230             


Ala Ala  Phe Val Glu Lys Cys  Cys Lys Ala Asp Asp  Lys Glu Thr 
    1235                 1240                 1245             


Cys Phe  Ala Glu Glu Gly Pro  Lys Leu Val Ala Ala  Ser Gln Ala 
    1250                 1255                 1260             


Ala Leu  Gly Leu His His His  His His His His His  
    1265                 1270                 1275 


<210>  36
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr 
145                 150                 155                 160 


Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
                165                 170                 175     


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            180                 185                 190         


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        195                 200                 205             


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    210                 215                 220                 


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
225                 230                 235                 240 


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                245                 250                 255     


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            260                 265                 270         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        275                 280                 285             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    290                 295                 300                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
305                 310                 315                 320 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                325                 330                 335     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            340                 345                 350         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        355                 360                 365             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    370                 375                 380                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
385                 390                 395                 400 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                405                 410                 415     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            420                 425                 430         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        435                 440                 445             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    450                 455                 460                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
465                 470                 475                 480 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                485                 490                 495     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            500                 505                 510         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        515                 520                 525             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    530                 535                 540                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
545                 550                 555                 560 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                565                 570                 575     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            580                 585                 590         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        595                 600                 605             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    610                 615                 620                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
625                 630                 635                 640 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                645                 650                 655     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            660                 665                 670         


Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    690                 695                 700                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
705                 710                 715                 720 


Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ile Ala Tyr Ala Met 
                725                 730                 735     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
            740                 745                 750         


Ile Thr Asn Phe Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
        755                 760                 765             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu 
    770                 775                 780                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
785                 790                 795                 800 


Ala Asp Arg Ser Ala Gln Thr Met Arg Gln Val Arg Pro Val Leu Pro 
                805                 810                 815     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser His His His His His 
            820                 825                 830         


His His His 
        835 


<210>  37
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr 
145                 150                 155                 160 


Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
                165                 170                 175     


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            180                 185                 190         


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        195                 200                 205             


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    210                 215                 220                 


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
225                 230                 235                 240 


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                245                 250                 255     


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            260                 265                 270         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        275                 280                 285             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    290                 295                 300                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
305                 310                 315                 320 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                325                 330                 335     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            340                 345                 350         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        355                 360                 365             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    370                 375                 380                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
385                 390                 395                 400 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                405                 410                 415     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            420                 425                 430         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        435                 440                 445             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    450                 455                 460                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
465                 470                 475                 480 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                485                 490                 495     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            500                 505                 510         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        515                 520                 525             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    530                 535                 540                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
545                 550                 555                 560 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                565                 570                 575     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            580                 585                 590         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        595                 600                 605             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    610                 615                 620                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
625                 630                 635                 640 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                645                 650                 655     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            660                 665                 670         


Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    690                 695                 700                 


Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
705                 710                 715                 720 


Lys Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Ser Ser Val 
                725                 730                 735     


Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Glu Leu Val Ala Ala 
            740                 745                 750         


Ile Thr Ser Gly Gly Ser Thr Asn Thr Ala Asp Ser Val Lys Gly Arg 
        755                 760                 765             


Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
    770                 775                 780                 


Arg Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Ala 
785                 790                 795                 800 


Gly Arg Asn Trp Val Pro Ile Ser Arg Tyr Ser Pro Gly Pro Tyr Trp 
                805                 810                 815     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His His 
            820                 825                 830         


His His 
        


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr 
145                 150                 155                 160 


Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
                165                 170                 175     


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            180                 185                 190         


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        195                 200                 205             


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    210                 215                 220                 


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
225                 230                 235                 240 


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                245                 250                 255     


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            260                 265                 270         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        275                 280                 285             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    290                 295                 300                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
305                 310                 315                 320 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                325                 330                 335     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            340                 345                 350         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        355                 360                 365             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    370                 375                 380                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
385                 390                 395                 400 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                405                 410                 415     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            420                 425                 430         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        435                 440                 445             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    450                 455                 460                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
465                 470                 475                 480 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                485                 490                 495     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            500                 505                 510         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        515                 520                 525             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    530                 535                 540                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
545                 550                 555                 560 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                565                 570                 575     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            580                 585                 590         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        595                 600                 605             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    610                 615                 620                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
625                 630                 635                 640 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                645                 650                 655     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            660                 665                 670         


Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    690                 695                 700                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
705                 710                 715                 720 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                725                 730                 735     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            740                 745                 750         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        755                 760                 765             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    770                 775                 780                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
785                 790                 795                 800 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                805                 810                 815     


Ser His His His His His His His His 
            820                 825 


<210>  40
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  40

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  41
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  41

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala 
145                 150                 155                 160 


Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly 
                165                 170                 175     


Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala 
            180                 185                 190         


Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys 
        195                 200                 205             


Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr 
    210                 215                 220                 


Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe 
225                 230                 235                 240 


Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser 
                245                 250                 255     


Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp 
            260                 265                 270         


Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys 
        275                 280                 285             


Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala 
    290                 295                 300                 


Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu 
305                 310                 315                 320 


Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met 
                325                 330                 335     


Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro 
            340                 345                 350         


His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu 
        355                 360                 365             


Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro 
    370                 375                 380                 


Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val 
385                 390                 395                 400 


Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe 
                405                 410                 415     


Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp 
            420                 425                 430         


Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala 
        435                 440                 445             


Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly 
    450                 455                 460                 


Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His 
465                 470                 475                 480 


Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu 
                485                 490                 495     


Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser 
            500                 505                 510         


Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val 
        515                 520                 525             


Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro 
    530                 535                 540                 


Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys 
545                 550                 555                 560 


Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr 
                565                 570                 575     


Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg 
            580                 585                 590         


Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp 
        595                 600                 605             


Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr 
    610                 615                 620                 


Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp 
625                 630                 635                 640 


Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp 
                645                 650                 655     


His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu 
            660                 665                 670         


Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gln Leu Val 
    690                 695                 700                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
705                 710                 715                 720 


Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val 
                725                 730                 735     


Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val Ser Ser Ile Ser Gly 
            740                 745                 750         


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        755                 760                 765             


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
    770                 775                 780                 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
785                 790                 795                 800 


Leu Ser Arg Ser Ser Gln Gly Thr Gln Val Thr Val Ser Ser His His 
                805                 810                 815     


His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
            820                 825                 830 


<210>  42
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    210                 215                 220                 


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu 
    290                 295                 300                 


Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp 
305                 310                 315                 320 


Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu 
                325                 330                 335     


Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg 
            340                 345                 350         


Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp 
        355                 360                 365             


Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro 
    370                 375                 380                 


Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val 
385                 390                 395                 400 


Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser 
                405                 410                 415     


Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr 
            420                 425                 430         


Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys 
        435                 440                 445             


Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln 
    450                 455                 460                 


Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala 
465                 470                 475                 480 


Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe 
                485                 490                 495     


Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr 
            500                 505                 510         


Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr 
        515                 520                 525             


Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn 
    530                 535                 540                 


Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile 
545                 550                 555                 560 


Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly 
                565                 570                 575     


Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile 
            580                 585                 590         


Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu 
        595                 600                 605             


Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile 
    610                 615                 620                 


Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys 
625                 630                 635                 640 


Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu 
                645                 650                 655     


Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro 
            660                 665                 670         


Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val 
        675                 680                 685             


Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys 
    690                 695                 700                 


His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn 
705                 710                 715                 720 


Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile 
                725                 730                 735     


Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met 
            740                 745                 750         


Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly 
        755                 760                 765             


Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly 
    770                 775                 780                 


Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr 
785                 790                 795                 800 


Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His His 
                805                 810                 815     


His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
            820                 825                 830 


<210>  43
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  43

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val Ser 
        35                  40                  45              


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr Ala Met Ala Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Asp Trp 
            180                 185                 190         


Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Met Ala Arg Gln 
225                 230                 235                 240 


Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
    290                 295                 300                 


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
305                 310                 315                 320 


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
                325                 330                 335     


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
            340                 345                 350         


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
        355                 360                 365             


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
    370                 375                 380                 


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
385                 390                 395                 400 


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
                405                 410                 415     


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
            420                 425                 430         


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
        435                 440                 445             


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
    450                 455                 460                 


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
465                 470                 475                 480 


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
                485                 490                 495     


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
            500                 505                 510         


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
        515                 520                 525             


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
    530                 535                 540                 


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
545                 550                 555                 560 


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
                565                 570                 575     


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
            580                 585                 590         


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
        595                 600                 605             


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
    610                 615                 620                 


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
625                 630                 635                 640 


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
                645                 650                 655     


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
            660                 665                 670         


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
        675                 680                 685             


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
    690                 695                 700                 


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
705                 710                 715                 720 


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
                725                 730                 735     


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
            740                 745                 750         


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
        755                 760                 765             


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
    770                 775                 780                 


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
785                 790                 795                 800 


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His His His 
                805                 810                 815     


His His His His His Trp Ser His Pro Gln Phe Glu Lys 
            820                 825                 


<210>  44
<211>  1278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala 
145                 150                 155                 160 


Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly 
                165                 170                 175     


Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala 
            180                 185                 190         


Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys 
        195                 200                 205             


Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr 
    210                 215                 220                 


Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe 
225                 230                 235                 240 


Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser 
                245                 250                 255     


Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp 
            260                 265                 270         


Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys 
        275                 280                 285             


Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala 
    290                 295                 300                 


Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu 
305                 310                 315                 320 


Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met 
                325                 330                 335     


Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro 
            340                 345                 350         


His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu 
        355                 360                 365             


Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro 
    370                 375                 380                 


Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val 
385                 390                 395                 400 


Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe 
                405                 410                 415     


Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp 
            420                 425                 430         


Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala 
        435                 440                 445             


Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly 
    450                 455                 460                 


Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His 
465                 470                 475                 480 


Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu 
                485                 490                 495     


Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser 
            500                 505                 510         


Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val 
        515                 520                 525             


Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro 
    530                 535                 540                 


Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys 
545                 550                 555                 560 


Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr 
                565                 570                 575     


Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg 
            580                 585                 590         


Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp 
        595                 600                 605             


Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr 
    610                 615                 620                 


Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp 
625                 630                 635                 640 


Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp 
                645                 650                 655     


His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu 
            660                 665                 670         


Met Pro Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His 
        675                 680                 685             


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
    690                 695                 700                 


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
705                 710                 715                 720 


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
                725                 730                 735     


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
            740                 745                 750         


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
        755                 760                 765             


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
    770                 775                 780                 


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
785                 790                 795                 800 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
                805                 810                 815     


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
            820                 825                 830         


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
        835                 840                 845             


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
    850                 855                 860                 


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
865                 870                 875                 880 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
                885                 890                 895     


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
            900                 905                 910         


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
        915                 920                 925             


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
    930                 935                 940                 


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
945                 950                 955                 960 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
                965                 970                 975     


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
            980                 985                 990         


Asp Val Cys Lys Asn Tyr Ala Glu  Ala Lys Asp Val Phe  Leu Gly Met 
        995                 1000                 1005             


Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro Asp Tyr  Ser Val Val 
    1010                 1015                 1020             


Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu Thr Thr  Leu Glu Lys 
    1025                 1030                 1035             


Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys Tyr Ala  Lys Val Phe 
    1040                 1045                 1050             


Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro Gln Asn  Leu Ile Lys 
    1055                 1060                 1065             


Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly Glu Tyr  Lys Phe Gln 
    1070                 1075                 1080             


Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys Val Pro  Gln Val Ser 
    1085                 1090                 1095             


Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn Leu Gly  Lys Val Gly 
    1100                 1105                 1110             


Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys Arg Met  Pro Cys Ala 
    1115                 1120                 1125             


Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln Leu Cys  Val Leu His 
    1130                 1135                 1140             


Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr Lys Cys  Cys Thr Glu 
    1145                 1150                 1155             


Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser Ala Leu  Glu Val Asp 
    1160                 1165                 1170             


Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala Glu Thr  Phe Thr Phe 
    1175                 1180                 1185             


His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys 
    1190                 1195                 1200             


Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys His Lys  Pro Lys Ala 
    1205                 1210                 1215             


Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe 
    1220                 1225                 1230             


Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala 
    1235                 1240                 1245             


Glu Glu  Gly Pro Lys Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly 
    1250                 1255                 1260             


Leu His  His His His His His  Trp Ser His Pro Gln  Phe Glu Lys 
    1265                 1270                 1275             


<210>  45
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  45

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Lys Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


Ser Leu Gly Lys 
    210         


<210>  46
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  46

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val 
            20                  25                  30          


Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly 
        35                  40                  45              


Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser 
    50                  55                  60                  


Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser 
65                  70                  75                  80  


Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr 
                85                  90                  95      


Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile 
            100                 105                 110         


Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys 
        115                 120                 125             


Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr 
    130                 135                 140                 


Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn 
145                 150                 155                 160 


Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu 
                165                 170                 175     


Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys 
            180                 185                 190         


Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser 
        195                 200                 205             


Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro 
    210                 215                 220                 


Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile 
225                 230                 235                 240 


Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala 
                245                 250                 255     


Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu 
            260                 265                 270         


Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys 
        275                 280                 285             


Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val 
    290                 295                 300                 


Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr 
305                 310                 315                 320 


Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly 
                325                 330                 335     


Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu 
            340                 345                 350         


Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu 
        355                 360                 365             


Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met 
    370                 375                 380                 


Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe 
385                 390                 395                 400 


Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro 
                405                 410                 415     


Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu 
            420                 425                 430         


Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly 
        435                 440                 445             


Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp 
    450                 455                 460                 


Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile 
465                 470                 475                 480 


Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val 
                485                 490                 495     


Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala 
            500                 505                 510         


Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met 
        515                 520                 525             


Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
    530                 535                 540             


<210>  47
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  47

Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
1               5                   10                  15      


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
            20                  25                  30          


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
        35                  40                  45              


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
    50                  55                  60                  


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
65                  70                  75                  80  


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
                85                  90                  95      


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
            100                 105                 110         


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
        115                 120                 125             


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
    130                 135                 140                 


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
                165                 170                 175     


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
            180                 185                 190         


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
        195                 200                 205             


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
    210                 215                 220                 


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
225                 230                 235                 240 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
                245                 250                 255     


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
            260                 265                 270         


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
        275                 280                 285             


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
    290                 295                 300                 


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
305                 310                 315                 320 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
                325                 330                 335     


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
            340                 345                 350         


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
        355                 360                 365             


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
    370                 375                 380                 


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
385                 390                 395                 400 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
                405                 410                 415     


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
            420                 425                 430         


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
        435                 440                 445             


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
    450                 455                 460                 


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
465                 470                 475                 480 


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
                485                 490                 495     


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
            500                 505                 510         


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
        515                 520                 525             


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
    530                 535                 540                 


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
545                 550                 555                 560 


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
                565                 570                 575     


Gly Pro Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590 


<210>  48
<211>  1292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  48

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser 
                165                 170                 175     


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
            180                 185                 190         


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
        195                 200                 205             


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
    210                 215                 220                 


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
225                 230                 235                 240 


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
                245                 250                 255     


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
            260                 265                 270         


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
        275                 280                 285             


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
    290                 295                 300                 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
305                 310                 315                 320 


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
                325                 330                 335     


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
            340                 345                 350         


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
        355                 360                 365             


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
385                 390                 395                 400 


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
                405                 410                 415     


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
            420                 425                 430         


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
        435                 440                 445             


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
    450                 455                 460                 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
465                 470                 475                 480 


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
                485                 490                 495     


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
            500                 505                 510         


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
        515                 520                 525             


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
    530                 535                 540                 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
545                 550                 555                 560 


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
                565                 570                 575     


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
            580                 585                 590         


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
        595                 600                 605             


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
    610                 615                 620                 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
625                 630                 635                 640 


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
                645                 650                 655     


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
            660                 665                 670         


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
        675                 680                 685             


Phe Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Asp Ala His Lys Ser 
    690                 695                 700                 


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
705                 710                 715                 720 


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
                725                 730                 735     


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
            740                 745                 750         


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
        755                 760                 765             


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
    770                 775                 780                 


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
785                 790                 795                 800 


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
                805                 810                 815     


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
            820                 825                 830         


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
        835                 840                 845             


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
    850                 855                 860                 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
865                 870                 875                 880 


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
                885                 890                 895     


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
            900                 905                 910         


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
        915                 920                 925             


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
    930                 935                 940                 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
945                 950                 955                 960 


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
                965                 970                 975     


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
            980                 985                 990         


Glu Asn Asp Glu Met Pro Ala Asp  Leu Pro Ser Leu Ala  Ala Asp Phe 
        995                 1000                 1005             


Val Glu  Ser Lys Asp Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp 
    1010                 1015                 1020             


Val Phe  Leu Gly Met Phe Leu  Tyr Glu Tyr Ala Arg  Arg His Pro 
    1025                 1030                 1035             


Asp Tyr  Ser Val Val Leu Leu  Leu Arg Leu Ala Lys  Thr Tyr Glu 
    1040                 1045                 1050             


Thr Thr  Leu Glu Lys Cys Cys  Ala Ala Ala Asp Pro  His Glu Cys 
    1055                 1060                 1065             


Tyr Ala  Lys Val Phe Asp Glu  Phe Lys Pro Leu Val  Glu Glu Pro 
    1070                 1075                 1080             


Gln Asn  Leu Ile Lys Gln Asn  Cys Glu Leu Phe Glu  Gln Leu Gly 
    1085                 1090                 1095             


Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val Arg Tyr  Thr Lys Lys 
    1100                 1105                 1110             


Val Pro  Gln Val Ser Thr Pro  Thr Leu Val Glu Val  Ser Arg Asn 
    1115                 1120                 1125             


Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys 
    1130                 1135                 1140             


Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
    1145                 1150                 1155             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1160                 1165                 1170             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1175                 1180                 1185             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1190                 1195                 1200             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1205                 1210                 1215             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1220                 1225                 1230             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1235                 1240                 1245             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1250                 1255                 1260             


Glu Thr  Cys Phe Ala Glu Glu  Gly Pro Lys Leu Val  Ala Ala Ser 
    1265                 1270                 1275             


Gln Ala  Ala Leu Gly Leu His  His His His His His  His His 
    1280                 1285                 1290         


<210>  49
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  49

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser 
                165                 170                 175     


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
            180                 185                 190         


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
        195                 200                 205             


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
    210                 215                 220                 


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
225                 230                 235                 240 


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
                245                 250                 255     


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
            260                 265                 270         


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
        275                 280                 285             


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
    290                 295                 300                 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
305                 310                 315                 320 


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
                325                 330                 335     


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
            340                 345                 350         


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
        355                 360                 365             


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
385                 390                 395                 400 


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
                405                 410                 415     


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
            420                 425                 430         


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
        435                 440                 445             


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
    450                 455                 460                 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
465                 470                 475                 480 


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
                485                 490                 495     


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
            500                 505                 510         


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
        515                 520                 525             


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
    530                 535                 540                 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
545                 550                 555                 560 


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
                565                 570                 575     


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
            580                 585                 590         


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
        595                 600                 605             


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
    610                 615                 620                 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
625                 630                 635                 640 


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
                645                 650                 655     


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
            660                 665                 670         


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
        675                 680                 685             


Phe Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
705                 710                 715                 720 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
                725                 730                 735     


Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ile Ala Tyr Ala 
            740                 745                 750         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        755                 760                 765             


Ala Ile Thr Asn Phe Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    770                 775                 780                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
785                 790                 795                 800 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                805                 810                 815     


Ala Ala Asp Arg Ser Ala Gln Thr Met Arg Gln Val Arg Pro Val Leu 
            820                 825                 830         


Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser His His His His 
        835                 840                 845             


His His His His 
    850         


<210>  50
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  50

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser 
                165                 170                 175     


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
            180                 185                 190         


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
        195                 200                 205             


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
    210                 215                 220                 


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
225                 230                 235                 240 


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
                245                 250                 255     


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
            260                 265                 270         


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
        275                 280                 285             


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
    290                 295                 300                 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
305                 310                 315                 320 


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
                325                 330                 335     


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
            340                 345                 350         


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
        355                 360                 365             


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
385                 390                 395                 400 


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
                405                 410                 415     


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
            420                 425                 430         


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
        435                 440                 445             


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
    450                 455                 460                 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
465                 470                 475                 480 


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
                485                 490                 495     


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
            500                 505                 510         


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
        515                 520                 525             


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
    530                 535                 540                 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
545                 550                 555                 560 


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
                565                 570                 575     


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
            580                 585                 590         


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
        595                 600                 605             


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
    610                 615                 620                 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
625                 630                 635                 640 


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
                645                 650                 655     


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
            660                 665                 670         


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
        675                 680                 685             


Phe Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
705                 710                 715                 720 


Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
                725                 730                 735     


Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Ser Ser 
            740                 745                 750         


Val Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Glu Leu Val Ala 
        755                 760                 765             


Ala Ile Thr Ser Gly Gly Ser Thr Asn Thr Ala Asp Ser Val Lys Gly 
    770                 775                 780                 


Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
785                 790                 795                 800 


Met Arg Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
                805                 810                 815     


Ala Gly Arg Asn Trp Val Pro Ile Ser Arg Tyr Ser Pro Gly Pro Tyr 
            820                 825                 830         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His 
        835                 840                 845             


His His His 
    850     


<210>  51
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  51

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val 
            20                  25                  30          


Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly 
        35                  40                  45              


Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser 
    50                  55                  60                  


Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser 
65                  70                  75                  80  


Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr 
                85                  90                  95      


Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile 
            100                 105                 110         


Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys 
        115                 120                 125             


Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr 
    130                 135                 140                 


Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn 
145                 150                 155                 160 


Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu 
                165                 170                 175     


Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys 
            180                 185                 190         


Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser 
        195                 200                 205             


Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro 
    210                 215                 220                 


Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile 
225                 230                 235                 240 


Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala 
                245                 250                 255     


Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu 
            260                 265                 270         


Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys 
        275                 280                 285             


Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val 
    290                 295                 300                 


Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr 
305                 310                 315                 320 


Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly 
                325                 330                 335     


Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu 
            340                 345                 350         


Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu 
        355                 360                 365             


Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met 
    370                 375                 380                 


Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe 
385                 390                 395                 400 


Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro 
                405                 410                 415     


Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu 
            420                 425                 430         


Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly 
        435                 440                 445             


Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp 
    450                 455                 460                 


Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile 
465                 470                 475                 480 


Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val 
                485                 490                 495     


Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala 
            500                 505                 510         


Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met 
        515                 520                 525             


Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His 
    530                 535                 540                 


His His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555                 


<210>  52
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  52

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His 
        35                  40                  45              


Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr 
        115                 120                 125             


Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
145                 150                 155                 160 


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
                165                 170                 175     


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
            180                 185                 190         


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
        195                 200                 205             


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
    210                 215                 220                 


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
225                 230                 235                 240 


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
                245                 250                 255     


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
            260                 265                 270         


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
        275                 280                 285             


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
    290                 295                 300                 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
305                 310                 315                 320 


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
                325                 330                 335     


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
            340                 345                 350         


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
        355                 360                 365             


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
    370                 375                 380                 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
385                 390                 395                 400 


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
                405                 410                 415     


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
            420                 425                 430         


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
        435                 440                 445             


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
    450                 455                 460                 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
465                 470                 475                 480 


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
                485                 490                 495     


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
            500                 505                 510         


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
        515                 520                 525             


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
    530                 535                 540                 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
545                 550                 555                 560 


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
                565                 570                 575     


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
            580                 585                 590         


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
        595                 600                 605             


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
    610                 615                 620                 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
625                 630                 635                 640 


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
                645                 650                 655     


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His His His 
            660                 665                 670         


His His His His His Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685 


<210>  53
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  53

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser 
                165                 170                 175     


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
            180                 185                 190         


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
        195                 200                 205             


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
    210                 215                 220                 


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
225                 230                 235                 240 


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
                245                 250                 255     


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
            260                 265                 270         


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
        275                 280                 285             


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
    290                 295                 300                 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
305                 310                 315                 320 


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
                325                 330                 335     


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
            340                 345                 350         


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
        355                 360                 365             


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
385                 390                 395                 400 


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
                405                 410                 415     


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
            420                 425                 430         


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
        435                 440                 445             


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
    450                 455                 460                 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
465                 470                 475                 480 


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
                485                 490                 495     


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
            500                 505                 510         


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
        515                 520                 525             


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
    530                 535                 540                 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
545                 550                 555                 560 


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
                565                 570                 575     


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
            580                 585                 590         


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
        595                 600                 605             


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
    610                 615                 620                 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
625                 630                 635                 640 


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
                645                 650                 655     


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
            660                 665                 670         


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
        675                 680                 685             


Phe Gln Leu Leu Met Pro His His His His His His His His Trp Ser 
    690                 695                 700                 


His Pro Gln Phe Glu Lys 
705                 710 


<210>  54
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  54

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
        35                  40                  45              


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp 
                165                 170                 175     


Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu 
            180                 185                 190         


Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu 
        195                 200                 205             


Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val 
    210                 215                 220                 


Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr 
225                 230                 235                 240 


Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn 
                245                 250                 255     


Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met 
            260                 265                 270         


Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp 
        275                 280                 285             


Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu 
    290                 295                 300                 


Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His 
305                 310                 315                 320 


Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr 
                325                 330                 335     


Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys 
            340                 345                 350         


Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys 
        355                 360                 365             


Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro 
    370                 375                 380                 


Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp 
                405                 410                 415     


Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp 
            420                 425                 430         


Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu 
        435                 440                 445             


Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu 
    450                 455                 460                 


Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu 
465                 470                 475                 480 


Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr 
                485                 490                 495     


His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro 
            500                 505                 510         


Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala 
        515                 520                 525             


Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu 
    530                 535                 540                 


Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro 
545                 550                 555                 560 


Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly 
                565                 570                 575     


Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro 
            580                 585                 590         


Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro 
        595                 600                 605             


Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys 
    610                 615                 620                 


Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr 
625                 630                 635                 640 


Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser 
                645                 650                 655     


Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln 
            660                 665                 670         


Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu 
        675                 680                 685             


Leu Met Pro His His His His His His His His Trp Ser His Pro Gln 
    690                 695                 700                 


Phe Glu Lys 
705         


<210>  55
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  55

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Pro Cys Ile Pro Lys 
                165                 170                 175     


Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys 
            180                 185                 190         


Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg 
        195                 200                 205             


Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro 
    210                 215                 220                 


Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro 
225                 230                 235                 240 


Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp 
                245                 250                 255     


Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu 
            260                 265                 270         


Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile 
        275                 280                 285             


Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr 
    290                 295                 300                 


Ala Asp Thr Pro Asp Asp Phe Gln Leu Leu Asn Phe Ser Leu Pro Glu 
305                 310                 315                 320 


Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu 
                325                 330                 335     


Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr 
            340                 345                 350         


Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly 
        355                 360                 365             


Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys 
    370                 375                 380                 


Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr 
385                 390                 395                 400 


Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln 
                405                 410                 415     


Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp 
            420                 425                 430         


Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu 
        435                 440                 445             


Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val 
    450                 455                 460                 


Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His 
465                 470                 475                 480 


Trp Tyr Leu Asp Phe Leu Ala Pro Ala Asn Ala Thr Leu Gly Glu Thr 
                485                 490                 495     


His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val 
            500                 505                 510         


Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg 
        515                 520                 525             


Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val 
    530                 535                 540                 


Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro 
545                 550                 555                 560 


Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr 
                565                 570                 575     


Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe 
            580                 585                 590         


Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser 
        595                 600                 605             


Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser 
    610                 615                 620                 


Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr 
625                 630                 635                 640 


Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr 
                645                 650                 655     


Ser Ile His Thr Tyr Leu Trp Arg Arg Gln His His His His His His 
            660                 665                 670         


His His 
        


<210>  56
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  56

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe 
        35                  40                  45              


Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    50                  55                  60                  


Val Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser 
        115                 120                 125             


Arg Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser 
                165                 170                 175     


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
            180                 185                 190         


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
        195                 200                 205             


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
    210                 215                 220                 


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
225                 230                 235                 240 


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
                245                 250                 255     


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
            260                 265                 270         


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
        275                 280                 285             


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
    290                 295                 300                 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
305                 310                 315                 320 


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
                325                 330                 335     


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
            340                 345                 350         


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
        355                 360                 365             


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
    370                 375                 380                 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
385                 390                 395                 400 


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
                405                 410                 415     


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
            420                 425                 430         


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
        435                 440                 445             


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
    450                 455                 460                 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
465                 470                 475                 480 


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
                485                 490                 495     


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
            500                 505                 510         


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
        515                 520                 525             


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
    530                 535                 540                 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
545                 550                 555                 560 


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
                565                 570                 575     


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
            580                 585                 590         


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
        595                 600                 605             


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
    610                 615                 620                 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
625                 630                 635                 640 


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
                645                 650                 655     


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
            660                 665                 670         


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
        675                 680                 685             


Phe Gln Leu Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
705                 710                 715                 720 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
                725                 730                 735     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
            740                 745                 750         


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        755                 760                 765             


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
    770                 775                 780                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
785                 790                 795                 800 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                805                 810                 815     


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
            820                 825                 830         


Ser Ser His His His His His His His His 
        835                 840         


<210>  57
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  57

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
        35                  40                  45              


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp 
                165                 170                 175     


Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu 
            180                 185                 190         


Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu 
        195                 200                 205             


Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val 
    210                 215                 220                 


Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr 
225                 230                 235                 240 


Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn 
                245                 250                 255     


Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met 
            260                 265                 270         


Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp 
        275                 280                 285             


Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu 
    290                 295                 300                 


Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His 
305                 310                 315                 320 


Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr 
                325                 330                 335     


Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys 
            340                 345                 350         


Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys 
        355                 360                 365             


Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro 
    370                 375                 380                 


Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp 
                405                 410                 415     


Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp 
            420                 425                 430         


Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu 
        435                 440                 445             


Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu 
    450                 455                 460                 


Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu 
465                 470                 475                 480 


Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr 
                485                 490                 495     


His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro 
            500                 505                 510         


Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala 
        515                 520                 525             


Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu 
    530                 535                 540                 


Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro 
545                 550                 555                 560 


Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly 
                565                 570                 575     


Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro 
            580                 585                 590         


Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro 
        595                 600                 605             


Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys 
    610                 615                 620                 


Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr 
625                 630                 635                 640 


Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser 
                645                 650                 655     


Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln 
            660                 665                 670         


Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu 
        675                 680                 685             


Leu Met Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gln Leu 
705                 710                 715                 720 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
                725                 730                 735     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp 
            740                 745                 750         


Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val Ser Ser Ile Ser 
        755                 760                 765             


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    770                 775                 780                 


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
785                 790                 795                 800 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
                805                 810                 815     


Ser Leu Ser Arg Ser Ser Gln Gly Thr Gln Val Thr Val Ser Ser His 
            820                 825                 830         


His His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
        835                 840                 845         


<210>  58
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  58

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
        35                  40                  45              


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ala Val Gln Leu Val Glu Ser Gly Gly Gly 
                165                 170                 175     


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            180                 185                 190         


Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
    210                 215                 220                 


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
225                 230                 235                 240 


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val 
305                 310                 315                 320 


Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly 
                325                 330                 335     


Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser 
            340                 345                 350         


Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser 
        355                 360                 365             


Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr 
    370                 375                 380                 


Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile 
385                 390                 395                 400 


Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys 
                405                 410                 415     


Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr 
            420                 425                 430         


Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn 
        435                 440                 445             


Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu 
    450                 455                 460                 


Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys 
465                 470                 475                 480 


Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser 
                485                 490                 495     


Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro 
            500                 505                 510         


Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile 
        515                 520                 525             


Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala 
    530                 535                 540                 


Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu 
545                 550                 555                 560 


Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys 
                565                 570                 575     


Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val 
            580                 585                 590         


Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr 
        595                 600                 605             


Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly 
    610                 615                 620                 


Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu 
625                 630                 635                 640 


Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu 
                645                 650                 655     


Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met 
            660                 665                 670         


Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe 
        675                 680                 685             


Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro 
    690                 695                 700                 


Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu 
705                 710                 715                 720 


Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly 
                725                 730                 735     


Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp 
            740                 745                 750         


Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile 
        755                 760                 765             


Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val 
    770                 775                 780                 


Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala 
785                 790                 795                 800 


Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met 
                805                 810                 815     


Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His 
            820                 825                 830         


His His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
        835                 840                 845         


<210>  59
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  59

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser 
        35                  40                  45              


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp 
    50                  55                  60                  


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr Ala Met Ala 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile 
        195                 200                 205             


Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Met Ala 
                245                 250                 255     


Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val 
305                 310                 315                 320 


Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly 
                325                 330                 335     


Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser 
            340                 345                 350         


Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser 
        355                 360                 365             


Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr 
    370                 375                 380                 


Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile 
385                 390                 395                 400 


Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys 
                405                 410                 415     


Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr 
            420                 425                 430         


Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn 
        435                 440                 445             


Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu 
    450                 455                 460                 


Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys 
465                 470                 475                 480 


Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser 
                485                 490                 495     


Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro 
            500                 505                 510         


Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile 
        515                 520                 525             


Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala 
    530                 535                 540                 


Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu 
545                 550                 555                 560 


Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys 
                565                 570                 575     


Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val 
            580                 585                 590         


Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr 
        595                 600                 605             


Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly 
    610                 615                 620                 


Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu 
625                 630                 635                 640 


Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu 
                645                 650                 655     


Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met 
            660                 665                 670         


Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe 
        675                 680                 685             


Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro 
    690                 695                 700                 


Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu 
705                 710                 715                 720 


Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly 
                725                 730                 735     


Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp 
            740                 745                 750         


Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile 
        755                 760                 765             


Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val 
    770                 775                 780                 


Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala 
785                 790                 795                 800 


Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met 
                805                 810                 815     


Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro His 
            820                 825                 830         


His His His His His His His Trp Ser His Pro Gln Phe Glu Lys 
        835                 840                 845         


<210>  60
<211>  1295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  60

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
        35                  40                  45              


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp 
                165                 170                 175     


Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu 
            180                 185                 190         


Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu 
        195                 200                 205             


Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val 
    210                 215                 220                 


Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr 
225                 230                 235                 240 


Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn 
                245                 250                 255     


Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met 
            260                 265                 270         


Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp 
        275                 280                 285             


Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu 
    290                 295                 300                 


Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His 
305                 310                 315                 320 


Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr 
                325                 330                 335     


Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys 
            340                 345                 350         


Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys 
        355                 360                 365             


Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro 
    370                 375                 380                 


Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp 
                405                 410                 415     


Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp 
            420                 425                 430         


Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu 
        435                 440                 445             


Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu 
    450                 455                 460                 


Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu 
465                 470                 475                 480 


Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr 
                485                 490                 495     


His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro 
            500                 505                 510         


Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala 
        515                 520                 525             


Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu 
    530                 535                 540                 


Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro 
545                 550                 555                 560 


Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly 
                565                 570                 575     


Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro 
            580                 585                 590         


Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro 
        595                 600                 605             


Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys 
    610                 615                 620                 


Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr 
625                 630                 635                 640 


Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser 
                645                 650                 655     


Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln 
            660                 665                 670         


Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu 
        675                 680                 685             


Leu Met Pro Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala 
    690                 695                 700                 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
705                 710                 715                 720 


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
                725                 730                 735     


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
            740                 745                 750         


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
        755                 760                 765             


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
    770                 775                 780                 


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
785                 790                 795                 800 


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
                805                 810                 815     


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
            820                 825                 830         


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
        835                 840                 845             


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
    850                 855                 860                 


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
865                 870                 875                 880 


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
                885                 890                 895     


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
            900                 905                 910         


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
        915                 920                 925             


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
    930                 935                 940                 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
945                 950                 955                 960 


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
                965                 970                 975     


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
            980                 985                 990         


Glu Met Pro Ala Asp Leu Pro Ser  Leu Ala Ala Asp Phe  Val Glu Ser 
        995                 1000                 1005             


Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu 
    1010                 1015                 1020             


Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg His Pro  Asp Tyr Ser 
    1025                 1030                 1035             


Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu 
    1040                 1045                 1050             


Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys 
    1055                 1060                 1065             


Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu 
    1070                 1075                 1080             


Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys 
    1085                 1090                 1095             


Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln 
    1100                 1105                 1110             


Val Ser  Thr Pro Thr Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys 
    1115                 1120                 1125             


Val Gly  Ser Lys Cys Cys Lys  His Pro Glu Ala Lys  Arg Met Pro 
    1130                 1135                 1140             


Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu Asn Gln  Leu Cys Val 
    1145                 1150                 1155             


Leu His  Glu Lys Thr Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys 
    1160                 1165                 1170             


Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu 
    1175                 1180                 1185             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe 
    1190                 1195                 1200             


Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln 
    1205                 1210                 1215             


Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu Val Lys  His Lys Pro 
    1220                 1225                 1230             


Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
    1235                 1240                 1245             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1250                 1255                 1260             


Phe Ala  Glu Glu Gly Pro Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1265                 1270                 1275             


Leu Gly  Leu His His His His  His His Trp Ser His  Pro Gln Phe 
    1280                 1285                 1290             


Glu Lys  
    1295 


<210>  61
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  61

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu 
            20                  25                  30          


Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp 
        35                  40                  45              


Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu 
    50                  55                  60                  


Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg 
65                  70                  75                  80  


Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp 
                85                  90                  95      


Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro 
            100                 105                 110         


Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val 
        115                 120                 125             


Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser 
    130                 135                 140                 


Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr 
145                 150                 155                 160 


Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys 
                165                 170                 175     


Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln 
            180                 185                 190         


Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala 
        195                 200                 205             


Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe 
    210                 215                 220                 


Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr 
225                 230                 235                 240 


Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr 
                245                 250                 255     


Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn 
            260                 265                 270         


Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile 
        275                 280                 285             


Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly 
    290                 295                 300                 


Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile 
305                 310                 315                 320 


Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu 
                325                 330                 335     


Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile 
            340                 345                 350         


Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys 
        355                 360                 365             


Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu 
    370                 375                 380                 


Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro 
385                 390                 395                 400 


Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val 
                405                 410                 415     


Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys 
            420                 425                 430         


His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn 
        435                 440                 445             


Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile 
    450                 455                 460                 


Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met 
465                 470                 475                 480 


Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly 
                485                 490                 495     


Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly 
            500                 505                 510         


Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr 
        515                 520                 525             


Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                565                 570                 575     


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser 
            580                 585                 590         


Gly Arg Thr Phe Ile Ala Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
        595                 600                 605             


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Thr Asn Phe Ala Gly Gly 
    610                 615                 620                 


Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
625                 630                 635                 640 


Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
                645                 650                 655     


Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Asp Arg Ser Ala Gln Thr 
            660                 665                 670         


Met Arg Gln Val Arg Pro Val Leu Pro Tyr Trp Gly Gln Gly Thr Gln 
        675                 680                 685             


Val Thr Val Ser His His His His His His His His 
    690                 695                 700 


<210>  62
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  62

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu 
            20                  25                  30          


Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp 
        35                  40                  45              


Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu 
    50                  55                  60                  


Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg 
65                  70                  75                  80  


Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp 
                85                  90                  95      


Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro 
            100                 105                 110         


Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val 
        115                 120                 125             


Phe His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser 
    130                 135                 140                 


Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr 
145                 150                 155                 160 


Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys 
                165                 170                 175     


Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln 
            180                 185                 190         


Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala 
        195                 200                 205             


Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe 
    210                 215                 220                 


Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr 
225                 230                 235                 240 


Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr 
                245                 250                 255     


Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn 
            260                 265                 270         


Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile 
        275                 280                 285             


Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly 
    290                 295                 300                 


Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile 
305                 310                 315                 320 


Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu 
                325                 330                 335     


Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile 
            340                 345                 350         


Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys 
        355                 360                 365             


Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu 
    370                 375                 380                 


Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro 
385                 390                 395                 400 


Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val 
                405                 410                 415     


Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys 
            420                 425                 430         


His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn 
        435                 440                 445             


Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile 
    450                 455                 460                 


Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met 
465                 470                 475                 480 


Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly 
                485                 490                 495     


Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly 
            500                 505                 510         


Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr 
        515                 520                 525             


Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly 
                565                 570                 575     


Gly Leu Val Gln Ala Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            580                 585                 590         


Gly Ser Thr Phe Ser Ser Ser Ser Val Gly Trp Tyr Arg Gln Ala Pro 
        595                 600                 605             


Gly Gln Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Gly Ser Thr 
    610                 615                 620                 


Asn Thr Ala Asp Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asn 
625                 630                 635                 640 


Ala Lys Asn Thr Val Tyr Leu Gln Met Arg Asp Leu Lys Pro Glu Asp 
                645                 650                 655     


Thr Ala Val Tyr Tyr Cys Asn Val Ala Gly Arg Asn Trp Val Pro Ile 
            660                 665                 670         


Ser Arg Tyr Ser Pro Gly Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        675                 680                 685             


Val Ser Ser His His His His His His His His 
    690                 695                 


<210>  63
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  63

Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
1               5                   10                  15      


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            100                 105                 110         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Gln Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser 
            180                 185                 190         


Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Leu Gly Lys 
225                 230     


<210>  64
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  64

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
        35                  40                  45              


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys 
    130                 135                 140                 


Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly 
145                 150                 155                 160 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            180                 185                 190         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Lys Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        355                 360                 365             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala 
385                 390                 395                 400 


Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp 
                405                 410                 415     


Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro 
            420                 425                 430         


Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe 
        435                 440                 445             


Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly 
    450                 455                 460                 


Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg 
465                 470                 475                 480 


Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn 
                485                 490                 495     


Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser 
            500                 505                 510         


Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr 
        515                 520                 525             


His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro 
    530                 535                 540                 


Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp 
545                 550                 555                 560 


Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile 
                565                 570                 575     


Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala 
            580                 585                 590         


Val Gly Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe 
        595                 600                 605             


Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu 
    610                 615                 620                 


Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile 
625                 630                 635                 640 


Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly 
                645                 650                 655     


Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala 
            660                 665                 670         


Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu 
        675                 680                 685             


Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp 
    690                 695                 700                 


His Gly Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn 
705                 710                 715                 720 


Phe Asp Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg 
                725                 730                 735     


Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp 
            740                 745                 750         


Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met 
        755                 760                 765             


Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala 
    770                 775                 780                 


Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu 
785                 790                 795                 800 


Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp 
                805                 810                 815     


Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala 
            820                 825                 830         


Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp 
        835                 840                 845             


Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr 
    850                 855                 860                 


Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe 
865                 870                 875                 880 


Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp 
                885                 890                 895     


Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly 
            900                 905                 910         


Asp Leu Phe Gln Leu Leu Met Pro 
        915                 920 


<210>  65
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr 
        115                 120                 125             


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                165                 170                 175     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Lys Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            340                 345                 350         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Gln Ala Asn 
    370                 375                 380                 


Ser Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu 
385                 390                 395                 400 


Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn 
                405                 410                 415     


Ile Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala 
            420                 425                 430         


Gln Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg 
        435                 440                 445             


Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val 
    450                 455                 460                 


His Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly 
465                 470                 475                 480 


Tyr Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser 
                485                 490                 495     


Asn His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His 
            500                 505                 510         


Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp 
        515                 520                 525             


Gly Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val 
    530                 535                 540                 


Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln 
545                 550                 555                 560 


Leu Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val 
                565                 570                 575     


Gly Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln 
            580                 585                 590         


Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val 
        595                 600                 605             


Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg 
    610                 615                 620                 


Gln Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro 
625                 630                 635                 640 


Ile Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser 
                645                 650                 655     


Val Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp 
            660                 665                 670         


Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His 
        675                 680                 685             


Gly Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe 
    690                 695                 700                 


Asp Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr 
705                 710                 715                 720 


Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro 
                725                 730                 735     


Phe Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp 
            740                 745                 750         


Leu Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly 
        755                 760                 765             


Leu Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu 
    770                 775                 780                 


Cys Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu 
785                 790                 795                 800 


Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr 
                805                 810                 815     


Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys 
            820                 825                 830         


Pro Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile 
        835                 840                 845             


Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu 
    850                 855                 860                 


Ala Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser 
865                 870                 875                 880 


Asp Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp 
                885                 890                 895     


Leu Phe Gln Leu Leu Met Pro His His His His His His 
            900                 905                 


<210>  66
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  66

Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro 
1               5                   10                  15      


Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp 
            20                  25                  30          


Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln 
        35                  40                  45              


Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro 
    50                  55                  60                  


Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala 
65                  70                  75                  80  


Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val 
                85                  90                  95      


Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His 
            100                 105                 110         


Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser 
        115                 120                 125             


Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu 
    130                 135                 140                 


Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu 
                165                 170                 175     


Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr 
            180                 185                 190         


His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu 
        195                 200                 205             


Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp 
    210                 215                 220                 


Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg 
225                 230                 235                 240 


Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro 
                245                 250                 255     


Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser 
            260                 265                 270         


Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu 
        275                 280                 285             


Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp 
    290                 295                 300                 


Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val 
305                 310                 315                 320 


Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser 
                325                 330                 335     


Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp 
            340                 345                 350         


Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val 
        355                 360                 365             


Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln 
    370                 375                 380                 


Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg 
385                 390                 395                 400 


Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu 
                405                 410                 415     


Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln 
            420                 425                 430         


Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser 
        435                 440                 445             


Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr 
    450                 455                 460                 


Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn 
465                 470                 475                 480 


Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro 
                485                 490                 495     


Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe 
            500                 505                 510         


Gln Leu Leu Met Pro 
        515         


<210>  67
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  67

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  68
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  69
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Met Asp 
            20                  25                  30          


Pro Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Gly Ser Ser Thr Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Tyr Gly Ala Asn Trp Tyr Arg Asp Glu Tyr Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Glu Pro Lys Ser 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly 
        355 


<210>  70
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid

<400>  70

Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                245                 250                 255     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn 
            260                 265                 270         


Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        275                 280                 285             


Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365 


