
                                SEQUENCE LISTING

<110> OPHIUCHUS MEDICINE INC.
      HASSAN, Yasser

<120> ANTI-VIRAL PROTEINS
  

<130> 10207600-1PCT

<150> US 62/661836        
<151> 2018-04-24  

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 541
<212> PRT
<213> Artificial Sequence

<220> 
<223> RTA-PAPS1

<400> 1
Met Ile Phe Pro Lys Gln Tyr Pro Ile Ile Asn Phe Thr Thr Ala Gly
 1               5                  10                  15      
Ala Thr Val Gln Ser Tyr Thr Asn Phe Ile Arg Ala Val Arg Gly Arg
            20                  25                  30          
Leu Thr Thr Gly Ala Asp Val Arg His Glu Ile Pro Val Leu Pro Asn
        35                  40                  45              
Arg Val Gly Leu Pro Ile Asn Gln Arg Phe Ile Leu Val Glu Leu Ser
    50                  55                  60                  
Asn His Ala Glu Leu Ser Val Thr Leu Ala Leu Asp Val Thr Asn Ala
65                  70                  75                  80  
Tyr Val Val Gly Tyr Arg Ala Gly Asn Ser Ala Tyr Phe Phe His Pro
                85                  90                  95      
Asp Asn Gln Glu Asp Ala Glu Ala Ile Thr His Leu Phe Thr Asp Val
            100                 105                 110         
Gln Asn Arg Tyr Thr Phe Ala Phe Gly Gly Asn Tyr Asp Arg Leu Glu
        115                 120                 125             
Gln Leu Ala Gly Asn Leu Arg Glu Asn Ile Glu Leu Gly Asn Gly Pro
    130                 135                 140                 
Leu Glu Glu Ala Ile Ser Ala Leu Tyr Tyr Tyr Ser Thr Gly Gly Thr
145                 150                 155                 160 
Gln Leu Pro Thr Leu Ala Arg Ser Phe Ile Ile Cys Ile Gln Met Ile
                165                 170                 175     
Ser Glu Ala Ala Arg Phe Gln Tyr Ile Glu Gly Glu Met Arg Thr Arg
            180                 185                 190         
Ile Arg Tyr Asn Arg Arg Ser Ala Pro Asp Pro Ser Val Ile Thr Leu
        195                 200                 205             
Glu Asn Ser Trp Gly Arg Leu Ser Thr Ala Ile Gln Glu Ser Asn Gln
    210                 215                 220                 
Gly Ala Phe Ala Ser Pro Ile Gln Leu Gln Arg Arg Asn Gly Ser Lys
225                 230                 235                 240 
Phe Ser Val Tyr Asp Val Ser Ile Leu Ile Pro Ile Ile Ala Leu Met
                245                 250                 255     
Val Tyr Arg Cys Ala Pro Pro Pro Ser Ser Gln Phe Ser Leu Leu Ile
            260                 265                 270         
Arg Pro Val Val Pro Asn Phe Asn Ile Asn Thr Ile Thr Phe Asp Ala
        275                 280                 285             
Gly Asn Ala Thr Ile Asn Lys Tyr Ala Thr Phe Met Glu Ser Leu Arg
    290                 295                 300                 
Asn Glu Ala Lys Asp Pro Ser Leu Lys Cys Tyr Gly Ile Pro Met Leu
305                 310                 315                 320 
Pro Asn Thr Asn Ser Thr Ile Lys Tyr Leu Leu Val Lys Leu Gln Gly
                325                 330                 335     
Ala Ser Leu Lys Thr Ile Thr Leu Met Leu Arg Arg Asn Asn Leu Tyr
            340                 345                 350         
Val Met Gly Tyr Ser Asp Pro Tyr Asp Asn Lys Cys Arg Tyr His Ile
        355                 360                 365             
Phe Asn Asp Ile Lys Gly Thr Glu Tyr Ser Asp Val Glu Asn Thr Leu
    370                 375                 380                 
Cys Pro Ser Ser Asn Pro Arg Val Ala Lys Pro Ile Asn Tyr Asn Gly
385                 390                 395                 400 
Leu Tyr Pro Thr Leu Glu Lys Lys Ala Gly Val Thr Ser Arg Asn Gln
                405                 410                 415     
Val Gln Leu Gly Ile Gln Ile Leu Ser Ser Asp Ile Gly Lys Ile Ser
            420                 425                 430         
Gly Gln Gly Ser Phe Thr Glu Lys Ile Glu Ala Lys Phe Leu Leu Val
        435                 440                 445             
Ala Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Asn
    450                 455                 460                 
Gln Val Lys Thr Asn Phe Asn Arg Asp Phe Ser Pro Asn Asp Lys Val
465                 470                 475                 480 
Leu Asp Leu Glu Glu Asn Trp Gly Lys Ile Ser Thr Ala Ile His Asn
                485                 490                 495     
Ser Lys Asn Gly Ala Leu Pro Lys Pro Leu Glu Leu Lys Asn Ala Asp
            500                 505                 510         
Gly Thr Lys Trp Ile Val Leu Arg Val Asp Glu Ile Lys Pro Asp Val
        515                 520                 525             
Gly Leu Leu Asn Tyr Val Asn Gly Thr Cys Gln Ala Thr
    530                 535                 540     


<210> 2
<211> 556
<212> PRT
<213> Artificial Sequence

<220> 
<223> RTAM-PAPS1

<400> 2
Met His His His His His His Ile Phe Pro Lys Gln Tyr Pro Ile Ile
 1               5                  10                  15      
Asn Phe Thr Thr Ala Gly Ala Thr Val Gln Ser Tyr Thr Asn Phe Ile
            20                  25                  30          
Arg Ala Val Arg Gly Arg Leu Thr Thr Gly Ala Asp Val Arg His Glu
        35                  40                  45              
Ile Pro Val Leu Pro Asn Arg Val Gly Leu Pro Ile Asn Gln Arg Phe
    50                  55                  60                  
Ile Leu Val Glu Leu Ser Asn His Ala Glu Leu Ser Val Thr Leu Ala
65                  70                  75                  80  
Leu Asp Val Thr Asn Ala Tyr Val Val Gly Tyr Arg Ala Gly Asn Ser
                85                  90                  95      
Ala Tyr Phe Phe His Pro Asp Asn Gln Glu Asp Ala Glu Ala Ile Thr
            100                 105                 110         
His Leu Phe Thr Asp Val Gln Asn Arg Tyr Thr Phe Ala Phe Gly Gly
        115                 120                 125             
Asn Tyr Asp Arg Leu Glu Gln Leu Ala Gly Asn Leu Arg Glu Asn Ile
    130                 135                 140                 
Glu Leu Gly Asn Gly Pro Leu Glu Glu Ala Ile Ser Ala Leu Tyr Tyr
145                 150                 155                 160 
Tyr Ser Thr Gly Gly Thr Gln Leu Pro Thr Leu Ala Arg Ser Phe Ile
                165                 170                 175     
Ile Ala Ile Gln Met Ile Ser Glu Ala Ala Arg Phe Gln Tyr Ile Glu
            180                 185                 190         
Gly Glu Met Arg Thr Arg Ile Arg Tyr Asn Arg Arg Ser Ala Pro Asp
        195                 200                 205             
Pro Ser Val Ile Thr Leu Glu Asn Ser Trp Gly Arg Leu Ser Thr Ala
    210                 215                 220                 
Ile Gln Glu Ser Asn Gln Gly Ala Phe Ala Ser Pro Ile Gln Leu Gln
225                 230                 235                 240 
Arg Arg Asn Gly Ser Lys Phe Ser Val Tyr Asp Val Ser Ile Leu Ile
                245                 250                 255     
Pro Ile Ile Ala Leu Met Val Tyr Arg Ala Ala Pro Pro Pro Ser Ser
            260                 265                 270         
Gln Phe Gly Gly Gly Gly Ser Asp Val Ala Asp Ile Gly Gly Gly Gly
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Val Asn Thr Ile Ile Tyr Asn Val Gly Ser
    290                 295                 300                 
Thr Thr Ile Ser Lys Tyr Ala Thr Phe Leu Asn Asp Leu Arg Asn Glu
305                 310                 315                 320 
Ala Lys Asp Pro Ser Leu Lys Cys Tyr Gly Ile Pro Met Leu Pro Asn
                325                 330                 335     
Thr Asn Thr Asn Pro Lys Tyr Val Leu Val Glu Leu Gln Gly Ser Asn
            340                 345                 350         
Lys Lys Thr Ile Thr Leu Met Leu Arg Arg Asn Asn Leu Tyr Val Met
        355                 360                 365             
Gly Tyr Ser Asp Pro Phe Glu Thr Asn Lys Cys Arg Tyr His Ile Phe
    370                 375                 380                 
Asn Asp Ile Ser Gly Thr Glu Arg Gln Asp Val Glu Thr Thr Leu Cys
385                 390                 395                 400 
Pro Asn Ala Asn Ser Arg Val Ser Lys Asn Ile Asn Phe Asp Ser Arg
                405                 410                 415     
Tyr Pro Thr Leu Glu Ser Lys Ala Gly Val Lys Ser Arg Ser Gln Val
            420                 425                 430         
Gln Leu Gly Ile Gln Ile Leu Asp Ser Asn Ile Gly Lys Ile Ser Gly
        435                 440                 445             
Val Met Ser Phe Thr Glu Lys Thr Glu Ala Glu Phe Leu Leu Val Ala
    450                 455                 460                 
Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Asn Gln
465                 470                 475                 480 
Val Lys Thr Asn Phe Asn Arg Ala Phe Asn Pro Asn Pro Lys Val Leu
                485                 490                 495     
Asn Leu Gln Glu Thr Trp Gly Lys Ile Ser Thr Ala Ile His Asp Ala
            500                 505                 510         
Lys Asn Gly Val Leu Pro Lys Pro Leu Glu Leu Val Asp Ala Ser Gly
        515                 520                 525             
Ala Lys Trp Ile Val Leu Arg Val Asp Glu Ile Lys Pro Asp Val Ala
    530                 535                 540                 
Leu Leu Asn Tyr Val Gly Gly Ser Cys Gln Thr Thr
545                 550                 555     


<210> 3
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer RP1-A48

<400> 3
tttaacttta agaaggagat atacatatga tcttcccgaa acagtacc              48

<210> 4
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer RPAP1-A48

<400> 4
tttaacttta agaaggagat atacatatgc accaccatca ccaccata              48

<210> 5
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer RPAP1-B50

<400> 5
cagccggatc tcagtggtgg tgctcgagtt aggtagtctg gcaagaaccg            50
