                         SEQUENCE LISTING

<110>  Zymergen Inc.
 
<120>  ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF HISTAMINE BY 
       FERMENTATION

<130>  ZMGNP011PWO

<150>  US 62/660,875
<151>  2018-04-20

<160>  143   

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  Acinetobacter baumannii (strain AB0057)

<400>  1

Met Ile Leu Ser Pro Ala Asp Gln Glu Arg Ile Glu Thr Phe Trp Asn 
1               5                   10                  15      


Tyr Cys Leu Lys His Gln Tyr Phe Asn Ile Gly Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ser Ala Leu Phe Arg Phe Phe Lys Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Lys Asp Tyr Ser Asn Tyr Ala Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Lys Asp Val Met Ala Tyr Phe Ala Glu Ile Phe Gln Ile 
65                  70                  75                  80  


Pro Phe Glu Glu Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Ser Asp Ser Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Gly Lys Ile Ala Lys 
        115                 120                 125             


Leu Leu Gln Met Lys Ser Cys Val Ile Glu Ser Leu Asp Asn Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Ile His Lys Ile Lys Thr Asn Lys Glu Ser 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Met Thr Gly Ala Ile 
                165                 170                 175     


Asp Asp Ile Glu Met Ile Gln Glu Arg Leu Ala Gln Ile Gly Ile Met 
            180                 185                 190         


Arg Arg Asp Tyr Tyr Ile His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp His Pro Gln Ala Phe Ser Phe Ala His Gly Ile 
    210                 215                 220                 


Asp Ser Ile Cys Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Lys Arg Gln Asn Val Glu Arg Ile Ser Val 
                245                 250                 255     


Asp Val Asp Tyr Ile Ser Thr Arg Asp Gln Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Val Leu Leu Met Trp Ala Ala Ile Arg Ser Gln Thr 
        275                 280                 285             


Asn Leu Gln Arg Arg Gln Arg Ile Gln His Cys Leu Lys Met Ala Gln 
    290                 295                 300                 


Tyr Ala Val Asp Arg Phe Gln Ala Val Gly Ile Pro Ala Trp Arg Asn 
305                 310                 315                 320 


Pro Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Glu His Ile Trp 
                325                 330                 335     


Lys Lys His Tyr Leu Ala Thr Ser Gly Asn Met Ala His Leu Ile Thr 
            340                 345                 350         


Thr Ala His His Arg Asp Thr Arg Gln Ile Asp Ser Leu Ile Asp Asp 
        355                 360                 365             


Val Ile Phe Asp Leu Gln Gly Ala Ser Lys Arg Thr Val Gly Phe 
    370                 375                 380             


<210>  2
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  2

Met Thr Val Ala Pro Arg Ile Gly Thr Ala Thr Arg Thr Thr Ser Glu 
1               5                   10                  15      


Ser Asp Ile Thr Val Glu Ile Asn Leu Asp Gly Thr Gly Lys Val Asp 
            20                  25                  30          


Ile Asp Thr Gly Leu Pro Phe Phe Asp His Met Leu Thr Ala Phe Gly 
        35                  40                  45              


Val His Gly Ser Phe Asp Leu Lys Val His Ala Lys Gly Asp Ile Glu 
    50                  55                  60                  


Ile Asp Ala His His Thr Val Glu Asp Thr Ala Ile Val Leu Gly Gln 
65                  70                  75                  80  


Ala Leu Leu Asp Ala Ile Gly Asp Lys Lys Gly Ile Arg Arg Phe Ala 
                85                  90                  95      


Ser Cys Gln Leu Pro Met Asp Glu Ala Leu Val Glu Ser Val Val Asp 
            100                 105                 110         


Ile Ser Gly Arg Pro Tyr Phe Val Ile Ser Gly Glu Pro Asp His Met 
        115                 120                 125             


Ile Thr Ser Val Ile Gly Gly His Tyr Ala Thr Val Ile Asn Glu His 
    130                 135                 140                 


Phe Phe Glu Thr Leu Ala Leu Asn Ser Arg Ile Thr Leu His Val Ile 
145                 150                 155                 160 


Cys His Tyr Gly Arg Asp Pro His His Ile Thr Glu Ala Glu Tyr Lys 
                165                 170                 175     


Ala Val Ala Arg Ala Leu Arg Gly Ala Val Glu Met Asp Pro Arg Gln 
            180                 185                 190         


Thr Gly Ile Pro Ser Thr Lys Gly Ala Leu 
        195                 200         


<210>  3
<211>  297
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Asp Leu Val Asn His Leu Thr Asp Arg Leu Leu Phe Ala Ile Pro 
1               5                   10                  15      


Lys Lys Gly Arg Leu Tyr Ser Lys Ser Val Ser Ile Leu Asn Gly Ala 
            20                  25                  30          


Asp Ile Thr Phe His Arg Ser Gln Arg Leu Asp Ile Ala Leu Ser Thr 
        35                  40                  45              


Ser Leu Pro Val Ala Leu Ile Phe Leu Pro Ala Ala Asp Ile Pro Thr 
    50                  55                  60                  


Phe Val Gly Glu Gly Lys Cys Asp Leu Gly Ile Thr Gly Val Asp Gln 
65                  70                  75                  80  


Val Arg Glu Ser Asp Val Asp Val Asp Leu Ala Ile Asp Leu Gln Phe 
                85                  90                  95      


Gly Asn Cys Lys Leu Gln Val Gln Val Pro Val Asn Gly Glu Tyr Lys 
            100                 105                 110         


Lys Pro Glu Gln Leu Ile Gly Lys Thr Ile Val Thr Ser Phe Val Lys 
        115                 120                 125             


Leu Ala Glu Lys Tyr Phe Ala Asp Leu Glu Gly Thr Thr Val Glu Lys 
    130                 135                 140                 


Met Thr Thr Arg Ile Lys Phe Val Ser Gly Ser Val Glu Ala Ser Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Gly Asp Ala Ile Val Asp Leu Val Glu Ser Gly Glu 
                165                 170                 175     


Thr Met Arg Ala Ala Gly Leu Val Asp Ile Ala Thr Val Leu Ser Thr 
            180                 185                 190         


Ser Ala Tyr Leu Ile Glu Ser Lys Asn Pro Lys Ser Asp Lys Ser Leu 
        195                 200                 205             


Ile Ala Thr Ile Lys Ser Arg Ile Glu Gly Val Met Thr Ala Gln Arg 
    210                 215                 220                 


Phe Val Ser Cys Ile Tyr Asn Ala Pro Glu Asp Lys Leu Pro Glu Leu 
225                 230                 235                 240 


Leu Lys Val Thr Pro Gly Arg Arg Ala Pro Thr Ile Ser Lys Ile Asp 
                245                 250                 255     


Asp Glu Gly Trp Val Ala Val Ser Ser Met Ile Glu Arg Lys Thr Lys 
            260                 265                 270         


Gly Val Val Leu Asp Glu Leu Lys Arg Leu Gly Ala Ser Asp Ile Met 
        275                 280                 285             


Val Phe Glu Ile Ser Asn Cys Arg Val 
    290                 295         


<210>  4
<211>  311
<212>  PRT
<213>  Lactobacillus sp. (strain 30a)

<400>  4

Met Ser Glu Leu Asp Ala Lys Leu Asn Lys Leu Gly Val Asp Arg Ile 
1               5                   10                  15      


Ala Ile Ser Pro Tyr Lys Gln Trp Thr Arg Gly Tyr Met Glu Pro Gly 
            20                  25                  30          


Asn Ile Gly Asn Gly Tyr Val Thr Gly Leu Lys Val Asp Ala Gly Val 
        35                  40                  45              


Arg Asp Lys Ser Asp Asp Asp Val Leu Asp Gly Ile Val Ser Tyr Asp 
    50                  55                  60                  


Arg Ala Glu Thr Lys Asn Ala Tyr Ile Gly Gln Ile Asn Met Thr Thr 
65                  70                  75                  80  


Ala Ser Ser Phe Thr Gly Val Gln Gly Arg Val Ile Gly Tyr Asp Ile 
                85                  90                  95      


Leu Arg Ser Pro Glu Val Asp Lys Ala Lys Pro Leu Phe Thr Glu Thr 
            100                 105                 110         


Gln Trp Asp Gly Ser Glu Leu Pro Ile Tyr Asp Ala Lys Pro Leu Gln 
        115                 120                 125             


Asp Ala Leu Val Glu Tyr Phe Gly Thr Glu Gln Asp Arg Arg His Tyr 
    130                 135                 140                 


Pro Ala Pro Gly Ser Phe Ile Val Cys Ala Asn Lys Gly Val Thr Ala 
145                 150                 155                 160 


Glu Arg Pro Lys Asn Asp Ala Asp Met Lys Pro Gly Gln Gly Tyr Gly 
                165                 170                 175     


Val Trp Ser Ala Ile Ala Ile Ser Phe Ala Lys Asp Pro Thr Lys Asp 
            180                 185                 190         


Ser Ser Met Phe Val Glu Asp Ala Gly Val Trp Glu Thr Pro Asn Glu 
        195                 200                 205             


Asp Glu Leu Leu Glu Tyr Leu Glu Gly Arg Arg Lys Ala Met Ala Lys 
    210                 215                 220                 


Ser Ile Ala Glu Cys Gly Gln Asp Ala His Ala Ser Phe Glu Ser Ser 
225                 230                 235                 240 


Trp Ile Gly Phe Ala Tyr Thr Met Met Glu Pro Gly Gln Ile Gly Asn 
                245                 250                 255     


Ala Ile Thr Val Ala Pro Tyr Val Ser Leu Pro Ile Asp Ser Ile Pro 
            260                 265                 270         


Gly Gly Ser Ile Leu Thr Pro Asp Lys Asp Met Glu Ile Met Glu Asn 
        275                 280                 285             


Leu Thr Met Pro Glu Trp Leu Glu Lys Met Gly Tyr Lys Ser Leu Ser 
    290                 295                 300                 


Ala Asn Asn Ala Leu Lys Tyr 
305                 310     


<210>  5
<211>  297
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  5

Met Leu Asp Asn Thr Arg Leu Arg Ile Ala Ile Gln Lys Ser Gly Arg 
1               5                   10                  15      


Leu Ser Asp Asp Ser Arg Glu Leu Leu Ala Arg Cys Gly Ile Lys Ile 
            20                  25                  30          


Asn Leu His Thr Gln Arg Leu Ile Ala Met Ala Glu Asn Met Pro Ile 
        35                  40                  45              


Asp Ile Leu Arg Val Arg Asp Asp Asp Ile Pro Gly Leu Val Met Asp 
    50                  55                  60                  


Gly Val Val Asp Leu Gly Ile Ile Gly Glu Asn Val Leu Glu Glu Glu 
65                  70                  75                  80  


Leu Leu Asn Arg Arg Ala Gln Gly Glu Asp Pro Arg Tyr Leu Thr Leu 
                85                  90                  95      


Arg Arg Leu Asp Phe Gly Gly Cys Arg Leu Ser Leu Ala Thr Pro Val 
            100                 105                 110         


Asp Glu Ala Trp Asp Gly Pro Ala Ala Leu Asp Gly Lys Arg Ile Ala 
        115                 120                 125             


Thr Ser Tyr Pro His Leu Leu Lys Arg Tyr Leu Asp Gln Lys Gly Val 
    130                 135                 140                 


Ser Phe Lys Ser Cys Leu Leu Asn Gly Ser Val Glu Val Ala Pro Arg 
145                 150                 155                 160 


Ala Gly Leu Ala Asp Ala Ile Cys Asp Leu Val Ser Thr Gly Ala Thr 
                165                 170                 175     


Leu Glu Ala Asn Gly Leu Arg Glu Val Glu Val Ile Tyr Arg Ser Lys 
            180                 185                 190         


Ala Cys Leu Ile Gln Arg Asp Gly Glu Met Ala Gln Ser Lys Leu Ile 
        195                 200                 205             


Asp Lys Leu Leu Thr Arg Ile Gln Gly Val Ile Gln Ala Arg Glu Ser 
    210                 215                 220                 


Lys Tyr Ile Met Met His Ala Pro Ser Glu Arg Leu Glu Glu Val Ile 
225                 230                 235                 240 


Ala Leu Leu Pro Gly Ala Glu Arg Pro Thr Ile Leu Pro Leu Ala Gly 
                245                 250                 255     


Glu Gln Gln Arg Val Ala Met His Met Val Ser Ser Glu Thr Leu Phe 
            260                 265                 270         


Trp Glu Thr Met Glu Lys Leu Lys Ala Leu Gly Ala Ser Ser Ile Leu 
        275                 280                 285             


Val Leu Pro Ile Glu Lys Met Met Glu 
    290                 295         


<210>  6
<211>  387
<212>  PRT
<213>  Chromobacterium sp. LK1

<400>  6

Met Ser Leu Ser Pro Leu Asp Gln Asn Arg Ile Glu Ser Phe Trp Gln 
1               5                   10                  15      


Tyr Cys Leu Gln His Gln Tyr Phe Asn Leu Ala Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ala Pro Leu His Arg Phe Leu Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Asn Glu Ser Ser Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Arg Glu Val Met His Phe Phe Ala Glu Leu Phe His Ile 
65                  70                  75                  80  


Pro Phe Asp Glu Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Asp Ala Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Ser His Tyr Ser Val Ala Lys Ile Ile Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Ser Arg Ala Val Asp Ser Leu Pro Ser Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Val Ala Lys Ile Gln Gln Asp Gln Glu Arg 
145                 150                 155                 160 


His Pro Ile Val Phe Val Asn Val Gly Thr Thr Met Lys Gly Ala Val 
                165                 170                 175     


Asp Asp Ile Gly Val Ile Gln His Lys Leu Ala Glu Ala Gly Ile Pro 
            180                 185                 190         


Arg Gln Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Ala Pro Gln Pro Tyr Ser Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Ser Val Ser Gly His Lys Met Ile Gly Ser Pro Met Pro 
225                 230                 235                 240 


Cys Gly Ile Val Leu Ala Lys Arg Ser Asn Val Ser Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala Lys Asp Gln Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Met Met Leu Trp Ala Ala Ile Lys Ser Arg Pro 
        275                 280                 285             


Leu Ala Glu Trp Arg Arg Lys Val Arg His Cys Leu Asp Met Ala Gln 
    290                 295                 300                 


Tyr Ala Ile Asp Arg Leu Gln Ala Ala Gly Ile Gln Ala Trp Arg Cys 
305                 310                 315                 320 


Lys Asn Ser Ile Thr Val Val Phe Pro Ser Pro Ser Glu Pro Val Cys 
                325                 330                 335     


Asp Lys His Gly Leu Ala Arg Ser Gly Gly Thr Ala His Leu Ile Thr 
            340                 345                 350         


Thr Pro His His His Asp Ser Gln Arg Leu Asp Arg Leu Leu Asp Asp 
        355                 360                 365             


Ile Val Gln Asp Leu Gly Ala Met Thr Ala Pro Ala Gly Ala Thr Met 
    370                 375                 380                 


Ser Ala Ala 
385         


<210>  7
<211>  281
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  7

Met Leu Lys Ile Ala Val Pro Asn Lys Gly Ser Leu Ser Glu Arg Ala 
1               5                   10                  15      


Met Glu Ile Leu Ala Glu Ala Gly Tyr Ala Gly Arg Gly Asp Ser Lys 
            20                  25                  30          


Ser Leu Asn Val Phe Asp Glu Ala Asn Asn Val Glu Phe Phe Phe Leu 
        35                  40                  45              


Arg Pro Lys Asp Ile Ala Ile Tyr Val Ala Gly Gly Gln Leu Asp Leu 
    50                  55                  60                  


Gly Ile Thr Gly Arg Asp Leu Ala Arg Asp Ser Gln Ala Asp Val His 
65                  70                  75                  80  


Glu Val Leu Ser Leu Gly Phe Gly Ser Ser Thr Phe Arg Tyr Ala Ala 
                85                  90                  95      


Pro Ala Asp Glu Glu Trp Ser Ile Glu Lys Leu Asp Gly Lys Arg Ile 
            100                 105                 110         


Ala Thr Ser Tyr Pro Asn Leu Val Arg Asp Asp Leu Ala Ala Arg Gly 
        115                 120                 125             


Leu Ser Ala Glu Val Leu Arg Leu Asp Gly Ala Val Glu Val Ser Ile 
    130                 135                 140                 


Lys Leu Gly Val Ala Asp Ala Ile Ala Asp Val Val Ser Thr Gly Arg 
145                 150                 155                 160 


Thr Leu Arg Gln Gln Gly Leu Ala Pro Phe Gly Glu Val Leu Cys Thr 
                165                 170                 175     


Ser Glu Ala Val Ile Val Gly Arg Lys Asp Glu Lys Val Thr Pro Glu 
            180                 185                 190         


Gln Gln Ile Leu Leu Arg Arg Ile Gln Gly Ile Leu His Ala Gln Asn 
        195                 200                 205             


Phe Leu Met Leu Asp Tyr Lys Val Asp Arg Asp Asn Leu Asp Ala Ala 
    210                 215                 220                 


Thr Ala Val Thr Pro Gly Phe Ser Gly Pro Ala Val Ser Pro Leu Ala 
225                 230                 235                 240 


Arg Asp Asn Trp Val Ala Val Arg Ala Met Val Pro Arg Arg Ser Ala 
                245                 250                 255     


Asn Ala Ile Met Asp Lys Leu Ala Gly Leu Gly Ala Glu Ala Ile Leu 
            260                 265                 270         


Ala Ser Glu Ile Arg Ile Ala Arg Ile 
        275                 280     


<210>  8
<211>  334
<212>  PRT
<213>  Methanosarcina barkeri str. Wiesmoor

<400>  8

Met Gln Lys Tyr Glu Tyr Asp Pro Lys Trp Val Ile Asn Asn Ala Ile 
1               5                   10                  15      


Ser Ser Glu Arg Glu Phe Cys Thr Gly Tyr Gln Asn Pro Gly Ala Ser 
            20                  25                  30          


Gly Asn Gly Tyr Val Thr Thr Ile Lys Leu Ser Thr Gly Leu Val Asp 
        35                  40                  45              


Ile Thr Pro Trp Glu Lys Val Gln Ala Met Ser Glu His Glu Val Ile 
    50                  55                  60                  


Lys Phe Asp Arg Gly Cys Ser Asn Ile Val Ser Tyr Asp Arg Cys Glu 
65                  70                  75                  80  


Cys Asn Asp Ala Tyr Ile Gly Ala Ile Asn Met Leu Thr Ala Ser Ser 
                85                  90                  95      


Phe Ser Gly Leu Gln Gly Val Ile Trp Gly Tyr Asp Ile Ala Val Val 
            100                 105                 110         


Glu Asn Leu Arg Ser Arg Lys Leu Tyr Asp Gln Lys Trp Pro Ser Gly 
        115                 120                 125             


Asp Pro Asn Ser Glu Tyr Ser Thr Pro Val Tyr Ser Ile Glu Pro Leu 
    130                 135                 140                 


Leu Asn Ala Thr Glu Arg Leu Phe Gly His Ala Glu Pro Gly Lys Arg 
145                 150                 155                 160 


Arg Phe Asn Pro Ile Pro Gly Ser Met Val Val Cys Ala Asn Lys Ser 
                165                 170                 175     


Ala Thr Ser Asp Pro Ser Ser Asp Val Lys Glu Gly Trp Ala Phe Ser 
            180                 185                 190         


Val Ile Ser Leu Ala Ile Leu Glu Asn Arg Asn Ser Gly Ser Asn Leu 
        195                 200                 205             


Phe Ile Glu Asp Cys Asp Ile Ile Asp Ile Asn Asn Pro Asp Gly Thr 
    210                 215                 220                 


Arg Lys Thr Lys Glu Asp Val Lys Ala Met Leu Asp Thr Thr Leu Arg 
225                 230                 235                 240 


Lys Val Thr Glu Cys Thr Val Leu Cys Gly Leu Asp Gln His Ile Lys 
                245                 250                 255     


Tyr Lys Glu Ile Phe Ile Gly Tyr Lys Val Ile Lys Phe Asn Glu Lys 
            260                 265                 270         


Gln Val Gly Cys Ala Leu Ala Cys Ala Pro Tyr Val Thr Leu Ala Arg 
        275                 280                 285             


Asn Ala Val Pro Gln Gly Met Lys Pro Ser Lys Leu Thr Asp Met Asn 
    290                 295                 300                 


Ile Ser Gln Trp Glu Asn Ala Leu Asn Leu Gln Pro Leu Glu Lys Ile 
305                 310                 315                 320 


Glu Lys Ser Lys Ile Gly Ile Leu Gly Met Gly Val Leu Asp 
                325                 330                 


<210>  9
<211>  349
<212>  PRT
<213>  Methanosarcina barkeri (strain Fusaro / DSM 804)

<400>  9

Met Thr Leu His Ser Arg Tyr Ser Lys Leu Lys Gly Glu Asn Lys Met 
1               5                   10                  15      


Gln Lys Tyr Glu Tyr Asp Pro Lys Trp Val Ile Asn Asn Ala Ile Ser 
            20                  25                  30          


Ser Glu Arg Glu Phe Cys Thr Gly Tyr Gln Asn Pro Gly Ala Ser Gly 
        35                  40                  45              


Asn Gly Tyr Val Thr Thr Ile Lys Leu Ser Thr Gly Leu Val Asp Ile 
    50                  55                  60                  


Thr Pro Trp Glu Lys Val Gln Ala Met Ser Glu His Glu Val Ile Lys 
65                  70                  75                  80  


Phe Asp Arg Gly Cys Ser Asn Ile Val Ser Tyr Asp Arg Cys Glu Cys 
                85                  90                  95      


Asn Asp Ala Tyr Ile Gly Ala Ile Asn Met Leu Thr Ala Ser Ser Phe 
            100                 105                 110         


Ser Gly Leu Gln Gly Val Ile Trp Gly Tyr Asp Ile Ala Val Val Glu 
        115                 120                 125             


Asn Leu Arg Ser Arg Lys Leu Tyr Asp Gln Lys Trp Pro Ser Gly Asp 
    130                 135                 140                 


Pro Asn Ser Glu Tyr Ser Thr Pro Val Tyr Ser Ile Glu Pro Leu Leu 
145                 150                 155                 160 


Asn Ala Thr Glu Arg Leu Phe Gly His Ala Glu Pro Gly Lys Arg Arg 
                165                 170                 175     


Phe Asn Pro Ile Pro Gly Ser Met Val Val Cys Ala Asn Lys Ser Ala 
            180                 185                 190         


Thr Ser Asp Pro Ser Ser Asp Val Lys Glu Gly Trp Ala Phe Ser Val 
        195                 200                 205             


Ile Ser Leu Ala Ile Leu Glu Asn Arg Asn Ser Gly Ser Asn Leu Phe 
    210                 215                 220                 


Ile Glu Asp Cys Asp Ile Ile Asp Ile Asn Asn Pro Asp Gly Thr Arg 
225                 230                 235                 240 


Lys Thr Lys Glu Asp Val Lys Ala Met Leu Asp Thr Thr Leu Arg Lys 
                245                 250                 255     


Val Thr Glu Cys Thr Val Leu Cys Gly Leu Asp Gln His Ile Lys Tyr 
            260                 265                 270         


Lys Glu Ile Phe Ile Gly Tyr Lys Val Ile Lys Phe Asn Glu Lys Gln 
        275                 280                 285             


Val Gly Cys Ala Leu Ala Cys Ala Pro Tyr Val Thr Leu Ala Arg Asn 
    290                 295                 300                 


Ala Val Pro Gln Gly Met Lys Pro Ser Lys Leu Thr Asp Met Asn Ile 
305                 310                 315                 320 


Ser Gln Trp Glu Asn Ala Leu Asn Leu Gln Pro Leu Glu Lys Ile Glu 
                325                 330                 335     


Lys Ser Lys Ile Gly Ile Leu Gly Met Gly Val Leu Asp 
            340                 345                 


<210>  10
<211>  847
<212>  PRT
<213>  Drosophila melanogaster

<400>  10

Met Asp Phe Lys Glu Tyr Arg Gln Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Ile Ala Asp Tyr Leu Glu Asn Ile Arg Glu Arg Arg Val Phe Pro Asp 
            20                  25                  30          


Val Ser Pro Gly Tyr Met Arg Gln Leu Leu Pro Glu Ser Ala Pro Ile 
        35                  40                  45              


Glu Gly Glu Pro Trp Pro Lys Ile Phe Ser Asp Val Glu Arg Ile Val 
    50                  55                  60                  


Met Pro Gly Ile Thr His Trp Gln Ser Pro His Met His Ala Tyr Phe 
65                  70                  75                  80  


Pro Ala Leu Asn Ser Met Pro Ser Leu Leu Gly Asp Met Leu Ala Asp 
                85                  90                  95      


Ala Ile Asn Cys Leu Gly Phe Thr Trp Ala Ser Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Ile Ile Val Met Asn Trp Leu Gly Lys Met Ile Gly Leu 
        115                 120                 125             


Pro Asp Ala Phe Leu His Leu Ser Ser Gln Ser Gln Gly Gly Gly Val 
    130                 135                 140                 


Leu Gln Thr Thr Ala Ser Glu Ala Thr Leu Val Cys Leu Leu Ala Gly 
145                 150                 155                 160 


Arg Thr Arg Ala Ile Gln Arg Phe His Glu Arg His Pro Gly Tyr Gln 
                165                 170                 175     


Asp Ala Glu Ile Asn Ala Arg Leu Val Ala Tyr Cys Ser Asp Gln Ala 
            180                 185                 190         


His Ser Ser Val Glu Lys Ala Ala Leu Ile Gly Leu Val Arg Met Arg 
        195                 200                 205             


Tyr Ile Glu Ala Asp Asp Asp Leu Ala Met Arg Gly Lys Leu Leu Arg 
    210                 215                 220                 


Glu Ala Ile Glu Asp Asp Ile Lys Gln Gly Leu Val Pro Phe Trp Val 
225                 230                 235                 240 


Cys Ala Thr Leu Gly Thr Thr Gly Ser Cys Ser Phe Asp Asn Leu Glu 
                245                 250                 255     


Glu Ile Gly Ile Val Cys Ala Glu His His Leu Trp Leu His Val Asp 
            260                 265                 270         


Ala Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg Thr Trp 
        275                 280                 285             


Leu Arg Gly Ile Glu Arg Ala Asp Ser Ile Ala Phe Asn Pro Ser Lys 
    290                 295                 300                 


Trp Leu Met Val His Phe Asp Ala Thr Ala Leu Trp Val Arg Asp Ser 
305                 310                 315                 320 


Thr Ala Val His Arg Thr Phe Asn Val Glu Pro Leu Tyr Leu Gln His 
                325                 330                 335     


Glu Asn Ser Gly Val Ala Val Asp Phe Met His Trp Gln Ile Pro Leu 
            340                 345                 350         


Ser Arg Arg Phe Arg Ala Leu Lys Val Trp Phe Val Leu Arg Ser Tyr 
        355                 360                 365             


Gly Ile Lys Gly Leu Gln Arg His Ile Arg Glu Gly Val Arg Leu Ala 
    370                 375                 380                 


Gln Lys Phe Glu Ala Leu Val Leu Ala Asp His Arg Phe Glu Leu Pro 
385                 390                 395                 400 


Ala Lys Arg His Leu Gly Leu Val Val Phe Arg Ile Arg Gly Asp Asn 
                405                 410                 415     


Glu Ile Thr Glu Lys Leu Leu Lys Arg Leu Asn His Arg Gly Asn Leu 
            420                 425                 430         


His Cys Ile Pro Ser Ser Leu Lys Gly Gln Tyr Val Ile Arg Phe Thr 
        435                 440                 445             


Ile Thr Ser Thr His Thr Thr Leu Asp Asp Ile Val Lys Asp Trp Met 
    450                 455                 460                 


Glu Ile Arg Gln Val Ala Ser Thr Val Leu Glu Glu Met Asn Ile Thr 
465                 470                 475                 480 


Ile Ser Asn Arg Val Tyr Leu Lys Glu Thr Lys Glu Lys Asn Glu Ala 
                485                 490                 495     


Phe Gly Ser Ser Leu Leu Leu Ser Asn Ser Pro Leu Ser Pro Lys Val 
            500                 505                 510         


Val Asn Gly Ser Phe Ala Ala Ile Phe Asp Ala Asp Glu Phe Leu Ala 
        515                 520                 525             


Lys Thr Tyr Ala Gly Val Arg Ile Ala His Gln Glu Ser Pro Ser Met 
    530                 535                 540                 


Arg Arg Arg Val Arg Gly Ile Leu Met Ser Gly Lys Gln Phe Ser Leu 
545                 550                 555                 560 


Asp Ser His Met Asp Val Val Val Gln Thr Thr Leu Asp Ala Gly Asn 
                565                 570                 575     


Gly Ala Thr Arg Thr Ser Thr Thr Asn Ser Tyr Gly His Thr Thr Ser 
            580                 585                 590         


Ala Ala Gln Ala Asn Ser Glu Arg Gln Ala Ser Ile Gln Glu Asp Asn 
        595                 600                 605             


Glu Glu Ser Pro Glu Glu Thr Glu Leu Leu Ser Leu Cys Arg Thr Ser 
    610                 615                 620                 


Asn Val Pro Ser Pro Glu His Ala His Ser Leu Ser Thr Pro Ser Arg 
625                 630                 635                 640 


Ser Cys Ser Ser Ser Ser His Ser Leu Ile His Ser Leu Thr Gln Ser 
                645                 650                 655     


Ser Pro Arg Ser Ser Pro Val Asn Gln Phe Arg Pro Ile Thr Leu Cys 
            660                 665                 670         


Ala Val Pro Ser Gln Ser Gln Leu Ser Met Pro Leu Ala Met Pro Leu 
        675                 680                 685             


Pro Asn Arg Asn Val Thr Val Ser Val Asp Ser Leu Leu Asn Pro Val 
    690                 695                 700                 


Thr Thr Cys Asn Val Tyr His Gly Lys Arg Phe Leu Glu Pro Leu Glu 
705                 710                 715                 720 


Asn Leu Ala Gln Thr Ser Ala Ser Phe Ser Ser Ser Ile Phe Arg Leu 
                725                 730                 735     


Pro Thr Pro Ile Ala Thr Pro Thr Arg Glu Ser Pro Glu Asp Pro Asp 
            740                 745                 750         


Trp Pro Ala Lys Thr Phe Ser Gln Leu Leu Leu Glu Arg Tyr Ser Ser 
        755                 760                 765             


Gln Ser Gln Ser Leu Gly Asn Asn Ser Ser Thr Glu Ser Ser Ser Leu 
    770                 775                 780                 


Ser Gly Gly Ala Thr Pro Thr Pro Thr Pro Met Ser Ser Leu Asp Glu 
785                 790                 795                 800 


Leu Val Thr Pro Leu Leu Leu Ser Phe Ala Ser Pro Ser Gln Pro Met 
                805                 810                 815     


Leu Ser Ala His Gly Ile Gly Glu Gly Gln Arg Glu Gln Gly Ser Asp 
            820                 825                 830         


Ser Asp Ala Thr Val Cys Ser Thr Thr Ser Ser Met Glu Ser Leu 
        835                 840                 845         


<210>  11
<211>  413
<212>  PRT
<213>  Solanum lycopersicum

<400>  11

Met Glu Ser Asp Ile Lys Asn Glu Thr Ser Phe Gln Glu Leu Asp Met 
1               5                   10                  15      


Ile Leu Thr Gln Tyr Leu Glu Thr Leu Ser Glu Arg Lys Lys Tyr His 
            20                  25                  30          


Ile Gly Tyr Pro Ile Asn Met Cys Tyr Glu His His Ala Thr Leu Ala 
        35                  40                  45              


Pro Leu Leu Gln Phe His Leu Asn Asn Cys Gly Asp Pro Phe Thr Gln 
    50                  55                  60                  


His Pro Thr Asp Phe His Ser Lys Asp Phe Glu Val Ala Val Leu Asp 
65                  70                  75                  80  


Trp Phe Ala Gln Leu Trp Glu Ile Glu Lys Asp Glu Tyr Trp Gly Tyr 
                85                  90                  95      


Ile Thr Ser Gly Gly Thr Glu Gly Asn Leu His Gly Phe Trp Leu Gly 
            100                 105                 110         


Arg Arg Glu Leu Leu Pro Asn Gly Tyr Leu Tyr Ala Ser Lys Asp Ser 
        115                 120                 125             


His Tyr Ser Ile Phe Lys Ala Ala Arg Met Tyr Arg Met Glu Leu Gln 
    130                 135                 140                 


Thr Ile Asn Thr Leu Val Asn Gly Glu Ile Asp Tyr Glu Asp Leu Gln 
145                 150                 155                 160 


Ser Lys Leu Leu Val Asn Lys Asn Lys Pro Ala Ile Ile Asn Ile Asn 
                165                 170                 175     


Ile Gly Thr Thr Phe Lys Gly Ala Ile Asp Asp Leu Asp Phe Val Ile 
            180                 185                 190         


Gln Thr Leu Glu Asn Cys Gly Tyr Ser Asn Asp Asn Tyr Tyr Ile His 
        195                 200                 205             


Cys Asp Arg Ala Leu Cys Gly Leu Ile Leu Pro Phe Ile Lys His Ala 
    210                 215                 220                 


Lys Lys Ile Thr Phe Lys Lys Pro Ile Gly Ser Ile Ser Ile Ser Gly 
225                 230                 235                 240 


His Lys Phe Leu Gly Cys Pro Met Ser Cys Gly Val Gln Ile Thr Arg 
                245                 250                 255     


Arg Ser Tyr Val Ser Thr Leu Ser Lys Ile Glu Tyr Ile Asn Ser Ala 
            260                 265                 270         


Asp Ala Thr Ile Ser Gly Ser Arg Asn Gly Phe Thr Pro Ile Phe Leu 
        275                 280                 285             


Trp Tyr Cys Leu Ser Lys Lys Gly His Ala Arg Leu Gln Gln Asp Ser 
    290                 295                 300                 


Ile Thr Cys Ile Glu Asn Ala Arg Tyr Leu Lys Asp Arg Leu Leu Glu 
305                 310                 315                 320 


Ala Gly Ile Ser Val Met Leu Asn Asp Phe Ser Ile Thr Val Val Phe 
                325                 330                 335     


Glu Arg Pro Cys Asp His Lys Phe Ile Arg Arg Trp Asn Leu Cys Cys 
            340                 345                 350         


Leu Arg Gly Met Ala His Val Val Ile Met Pro Gly Ile Thr Arg Glu 
        355                 360                 365             


Thr Ile Asp Ser Phe Phe Lys Asp Leu Met Gln Glu Arg Asn Tyr Lys 
    370                 375                 380                 


Trp Tyr Gln Asp Val Lys Ala Leu Pro Pro Cys Leu Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Leu Asn Cys Met Cys Ser Asn Lys Lys Met His Asn 
                405                 410             


<210>  12
<211>  662
<212>  PRT
<213>  Mus musculus

<400>  12

Met Met Glu Pro Cys Glu Tyr Arg Glu Tyr Arg Glu Tyr Tyr Arg Ala 
1               5                   10                  15      


Arg Gly Lys Glu Met Val Asp Tyr Ile Ser Gln Tyr Leu Ser Thr Val 
            20                  25                  30          


Arg Glu Arg Gln Val Thr Pro Asn Val Gln Pro Gly Tyr Leu Arg Ala 
        35                  40                  45              


Gln Leu Pro Ala Ser Ala Pro Glu Glu Pro Asp Ser Trp Asp Ser Ile 
    50                  55                  60                  


Phe Gly Asp Ile Glu Arg Val Ile Met Pro Gly Val Val His Trp Gln 
65                  70                  75                  80  


Ser Pro His Met His Ala Tyr Tyr Pro Ala Leu Thr Ser Trp Pro Ser 
                85                  90                  95      


Leu Leu Gly Asp Met Leu Ala Asp Ala Ile Asn Cys Leu Gly Phe Thr 
            100                 105                 110         


Trp Ala Ser Ser Pro Ala Cys Thr Glu Leu Glu Met Asn Ile Met Asp 
        115                 120                 125             


Trp Leu Ala Lys Met Leu Gly Leu Pro Glu Tyr Phe Leu His His His 
    130                 135                 140                 


Pro Ser Ser Arg Gly Gly Gly Val Leu Gln Ser Thr Val Ser Glu Ser 
145                 150                 155                 160 


Thr Leu Ile Ala Leu Leu Ala Ala Arg Lys Asn Lys Ile Leu Ala Met 
                165                 170                 175     


Lys Ala Cys Glu Pro Asp Ala Asn Glu Ser Ser Leu Asn Ala Arg Leu 
            180                 185                 190         


Val Ala Tyr Thr Ser Asp Gln Ala His Ser Ser Val Glu Lys Ala Gly 
        195                 200                 205             


Leu Ile Ser Leu Val Lys Ile Arg Phe Leu Pro Val Asp Asp Asn Phe 
    210                 215                 220                 


Ser Leu Arg Gly Glu Ala Leu Gln Lys Ala Ile Glu Glu Asp Lys Gln 
225                 230                 235                 240 


Gln Gly Leu Val Pro Val Phe Val Cys Ala Thr Leu Gly Thr Thr Gly 
                245                 250                 255     


Val Cys Ala Phe Asp Arg Leu Ser Glu Leu Gly Pro Ile Cys Ala Ser 
            260                 265                 270         


Glu Gly Leu Trp Leu His Val Asp Ala Ala Tyr Ala Gly Thr Ala Phe 
        275                 280                 285             


Leu Cys Pro Glu Leu Arg Gly Phe Leu Glu Gly Ile Glu Tyr Ala Asp 
    290                 295                 300                 


Ser Phe Thr Phe Asn Pro Ser Lys Trp Met Met Val His Phe Asp Cys 
305                 310                 315                 320 


Thr Gly Phe Trp Val Lys Asp Lys Tyr Lys Leu Gln Gln Thr Phe Ser 
                325                 330                 335     


Val Asn Pro Ile Tyr Leu Arg His Ala Asn Ser Gly Ala Ala Thr Asp 
            340                 345                 350         


Phe Met His Trp Gln Ile Pro Leu Ser Arg Arg Phe Arg Ser Ile Lys 
        355                 360                 365             


Leu Trp Phe Val Ile Arg Ser Phe Gly Val Lys Asn Leu Gln Ala His 
    370                 375                 380                 


Val Arg His Gly Thr Glu Met Ala Lys Tyr Phe Glu Ser Leu Val Arg 
385                 390                 395                 400 


Ser Asp Pro Ser Phe Glu Ile Pro Ala Lys Arg His Leu Gly Leu Val 
                405                 410                 415     


Val Phe Arg Leu Lys Gly Pro Asn Cys Leu Thr Glu Ser Val Leu Lys 
            420                 425                 430         


Glu Ile Ala Lys Ala Gly Gln Leu Phe Leu Ile Pro Ala Thr Ile Gln 
        435                 440                 445             


Asp Lys Leu Ile Ile Arg Phe Thr Val Thr Ser Gln Phe Thr Thr Lys 
    450                 455                 460                 


Glu Asp Ile Leu Arg Asp Trp His Leu Ile Gln Glu Ala Ala Asn Leu 
465                 470                 475                 480 


Val Leu Ser Gln His Cys Thr Ser Gln Pro Ser Pro Arg Ala Lys Asn 
                485                 490                 495     


Val Ile Pro Pro Pro Pro Gly Thr Arg Gly Leu Ser Leu Glu Ser Val 
            500                 505                 510         


Ser Glu Gly Gly Asp Asp Pro Ala Gln Ala Arg Lys Ile Ile Lys Gln 
        515                 520                 525             


Pro Gly Ala Ser Leu Ala Arg Arg Glu Gly Gly Ser Asp Leu Glu Thr 
    530                 535                 540                 


Met Pro Asp Pro Phe Asp Asp Cys Phe Ser Glu Glu Ala Pro Asn Thr 
545                 550                 555                 560 


Thr Lys His Lys Leu Ser Ser Phe Leu Phe Ser Tyr Leu Ser Val Gln 
                565                 570                 575     


Asn Arg Arg Lys Thr Thr Arg Ser Leu Ser Cys Asn Ser Val Pro Met 
            580                 585                 590         


Ser Ala Gln Lys Ser Leu Pro Ala Asp Ala Ser Leu Lys Asn Gly Gly 
        595                 600                 605             


Ser Phe Arg Ala Arg Ile Phe Ser Gly Phe Pro Glu Gln Met Met Met 
    610                 615                 620                 


Met Lys Lys Gly Ala Phe Lys Lys Leu Ile Lys Phe Tyr Ser Val Pro 
625                 630                 635                 640 


Ser Phe Pro Glu Cys Ser Ser Gln Cys Ala Arg Gln Leu Pro Cys Cys 
                645                 650                 655     


Pro Leu Glu Ala Met Val 
            660         


<210>  13
<211>  246
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  13

Met Thr Phe Thr Ile Leu Pro Ala Val Asp Val Val Asn Gly Gln Ala 
1               5                   10                  15      


Val Arg Leu Asp Gln Gly Glu Ala Gly Thr Glu Lys Ser Tyr Gly Thr 
            20                  25                  30          


Pro Leu Glu Ser Ala Leu Lys Trp Gln Glu Gln Gly Ala Lys Trp Leu 
        35                  40                  45              


His Phe Val Asp Leu Asp Ala Ala Phe Asn Arg Gly Ser Asn His Glu 
    50                  55                  60                  


Met Met Ala Glu Ile Val Gly Lys Leu Asp Val Asp Val Glu Leu Thr 
65                  70                  75                  80  


Gly Gly Ile Arg Asp Asp Glu Ser Leu Glu Arg Ala Leu Ala Thr Gly 
                85                  90                  95      


Ala Arg Arg Val Asn Ile Gly Thr Ala Ala Leu Glu Lys Pro Glu Trp 
            100                 105                 110         


Ile Ala Ser Ala Ile Gln Arg Tyr Gly Glu Lys Ile Ala Val Asp Ile 
        115                 120                 125             


Ala Val Arg Leu Glu Asp Gly Glu Trp Arg Thr Arg Gly Asn Gly Trp 
    130                 135                 140                 


Val Ser Asp Gly Gly Asp Leu Trp Asp Val Leu Glu Arg Leu Asp Ser 
145                 150                 155                 160 


Gln Gly Cys Ala Arg Phe Val Val Thr Asp Val Ser Lys Asp Gly Thr 
                165                 170                 175     


Leu Ser Gly Pro Asn Val Glu Leu Leu Arg Glu Val Ala Ala Ala Thr 
            180                 185                 190         


Asp Ala Pro Ile Val Ala Ser Gly Gly Ile Ser Val Leu Glu Asp Val 
        195                 200                 205             


Leu Glu Leu Ala Lys Tyr Gln Asp Glu Gly Ile Asp Ser Val Ile Ile 
    210                 215                 220                 


Gly Lys Ala Leu Tyr Glu His Lys Phe Thr Leu Glu Glu Ala Leu Ala 
225                 230                 235                 240 


Ala Val Glu Lys Leu Gly 
                245     


<210>  14
<211>  366
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  14

Met Thr Lys Ile Thr Leu Ser Asp Leu Pro Leu Arg Glu Glu Leu Arg 
1               5                   10                  15      


Gly Glu His Ala Tyr Gly Ala Pro Gln Leu Asn Val Asp Ile Arg Leu 
            20                  25                  30          


Asn Thr Asn Glu Asn Pro Tyr Pro Pro Ser Glu Ala Leu Val Ala Asp 
        35                  40                  45              


Leu Val Ala Thr Val Asp Lys Ile Ala Thr Glu Leu Asn Arg Tyr Pro 
    50                  55                  60                  


Glu Arg Asp Ala Val Glu Leu Arg Asp Glu Leu Ala Ala Tyr Ile Thr 
65                  70                  75                  80  


Lys Gln Thr Gly Val Ala Val Thr Arg Asp Asn Leu Trp Ala Ala Asn 
                85                  90                  95      


Gly Ser Asn Glu Ile Leu Gln Gln Leu Leu Gln Ala Phe Gly Gly Pro 
            100                 105                 110         


Gly Arg Thr Ala Leu Gly Phe Gln Pro Ser Tyr Ser Met His Pro Ile 
        115                 120                 125             


Leu Ala Lys Gly Thr His Thr Glu Phe Ile Ala Val Ser Arg Gly Ala 
    130                 135                 140                 


Asp Phe Arg Ile Asp Met Asp Val Ala Leu Glu Glu Ile Arg Ala Lys 
145                 150                 155                 160 


Gln Pro Asp Ile Val Phe Val Thr Thr Pro Asn Asn Pro Thr Gly Asp 
                165                 170                 175     


Val Thr Ser Leu Asp Asp Ile Glu Arg Ile Ile Asn Val Ala Pro Gly 
            180                 185                 190         


Ile Val Ile Val Asp Glu Ala Tyr Ala Glu Phe Ser Pro Ser Pro Ser 
        195                 200                 205             


Ala Thr Thr Leu Leu Glu Lys Tyr Pro Thr Lys Leu Val Val Ser Arg 
    210                 215                 220                 


Thr Met Ser Lys Ala Phe Asp Phe Ala Gly Gly Arg Leu Gly Tyr Phe 
225                 230                 235                 240 


Val Ala Asn Pro Ala Phe Ile Asp Ala Val Met Leu Val Arg Leu Pro 
                245                 250                 255     


Tyr His Leu Ser Ala Leu Ser Gln Ala Ala Ala Ile Val Ala Leu Arg 
            260                 265                 270         


His Ser Ala Asp Thr Leu Gly Thr Val Glu Lys Leu Ser Val Glu Arg 
        275                 280                 285             


Val Arg Val Ala Ala Arg Leu Glu Glu Leu Gly Tyr Ala Val Val Pro 
    290                 295                 300                 


Ser Glu Ser Asn Phe Val Phe Phe Gly Asp Phe Ser Asp Gln His Ala 
305                 310                 315                 320 


Ala Trp Gln Ala Phe Leu Asp Arg Gly Val Leu Ile Arg Asp Val Gly 
                325                 330                 335     


Ile Ala Gly His Leu Arg Thr Thr Ile Gly Val Pro Glu Glu Asn Asp 
            340                 345                 350         


Ala Phe Leu Asp Ala Ala Ala Glu Ile Ile Lys Leu Asn Leu 
        355                 360                 365     


<210>  15
<211>  442
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  15

Met Leu Asn Val Thr Asp Leu Arg Gly Gln Thr Pro Ser Lys Ser Asp 
1               5                   10                  15      


Ile Arg Arg Ala Leu Pro Arg Gly Gly Thr Asp Val Trp Ser Val Leu 
            20                  25                  30          


Pro Ile Val Gln Pro Val Val Glu Asp Val Gln Asn Arg Gly Ala Glu 
        35                  40                  45              


Ala Ala Leu Asp Tyr Gly Glu Lys Phe Asp His Ile Arg Pro Ala Ser 
    50                  55                  60                  


Val Arg Val Pro Ala Glu Val Ile Ala Ala Ala Glu Asn Thr Leu Asp 
65                  70                  75                  80  


Pro Leu Val Arg Glu Ser Ile Glu Glu Ser Ile Arg Arg Val Arg Lys 
                85                  90                  95      


Val His Ala Glu Gln Lys Pro Ala Glu His Thr Thr Glu Leu Ser Pro 
            100                 105                 110         


Gly Gly Thr Val Thr Glu Arg Phe Met Pro Ile Asp Arg Val Gly Leu 
        115                 120                 125             


Tyr Val Pro Gly Gly Asn Ala Val Tyr Pro Ser Ser Val Ile Met Asn 
    130                 135                 140                 


Thr Val Pro Ala Gln Glu Ala Gly Val Asn Ser Leu Val Val Ala Ser 
145                 150                 155                 160 


Pro Pro Gln Ala Glu His Gly Gly Trp Pro His Pro Thr Ile Leu Ala 
                165                 170                 175     


Ala Cys Ser Ile Leu Gly Val Asp Glu Val Trp Ala Val Gly Gly Gly 
            180                 185                 190         


Gln Ala Val Ala Leu Leu Ala Tyr Gly Asp Asp Ala Ala Gly Leu Glu 
        195                 200                 205             


Pro Val Asp Met Ile Thr Gly Pro Gly Asn Ile Phe Val Thr Ala Ala 
    210                 215                 220                 


Lys Arg Leu Val Arg Gly Val Val Gly Thr Asp Ser Glu Ala Gly Pro 
225                 230                 235                 240 


Thr Glu Ile Ala Val Leu Ala Asp Ala Ser Ala Asn Ala Val Asn Val 
                245                 250                 255     


Ala Tyr Asp Leu Ile Ser Gln Ala Glu His Asp Val Met Ala Ala Ser 
            260                 265                 270         


Val Leu Ile Thr Asp Ser Glu Gln Leu Ala Lys Asp Val Asn Arg Glu 
        275                 280                 285             


Ile Glu Ala Arg Tyr Ser Ile Thr Arg Asn Ala Glu Arg Val Ala Glu 
    290                 295                 300                 


Ala Leu Arg Gly Ala Gln Ser Gly Ile Val Leu Val Asp Asp Ile Ser 
305                 310                 315                 320 


Val Gly Ile Gln Val Ala Asp Gln Tyr Ala Ala Glu His Leu Glu Ile 
                325                 330                 335     


His Thr Glu Asn Ala Arg Ala Val Ala Glu Gln Ile Thr Asn Ala Gly 
            340                 345                 350         


Ala Ile Phe Val Gly Asp Phe Ser Pro Val Pro Leu Gly Asp Tyr Ser 
        355                 360                 365             


Ala Gly Ser Asn His Val Leu Pro Thr Ser Gly Ser Ala Arg Phe Ser 
    370                 375                 380                 


Ala Gly Leu Ser Thr His Met Phe Leu Arg Pro Val Asn Leu Ile Glu 
385                 390                 395                 400 


Tyr Asp Glu Ala Ala Leu Lys Asp Val Ser Gln Val Val Ile Asn Phe 
                405                 410                 415     


Ala Asn Ala Glu Asp Leu Pro Ala His Gly Glu Ala Ile Arg Ala Arg 
            420                 425                 430         


Phe Glu Asn Leu Pro Thr Thr Asp Glu Ala 
        435                 440         


<210>  16
<211>  87
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  16

Val Lys Thr Phe Asp Ser Leu Tyr Glu Glu Leu Leu Asn Arg Ala Gln 
1               5                   10                  15      


Thr Arg Pro Glu Gly Ser Gly Thr Val Ala Ala Leu Asp Lys Gly Ile 
            20                  25                  30          


His His Leu Gly Lys Lys Val Ile Glu Glu Ala Gly Glu Val Trp Ile 
        35                  40                  45              


Ala Ala Glu Tyr Glu Thr Asp Glu Glu Leu Ala Gly Glu Ile Ser Gln 
    50                  55                  60                  


Leu Ile Tyr Trp Thr Gln Val Ile Met Val Ala Arg Gly Leu Lys Pro 
65                  70                  75                  80  


Glu Asp Ile Tyr Lys Asn Leu 
                85          


<210>  17
<211>  258
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  17

Met Gly Val Ala Ile Arg Val Ile Pro Cys Leu Asp Val Asp Asn Gly 
1               5                   10                  15      


Arg Val Val Lys Gly Val Asn Phe Glu Asn Leu Arg Asp Ala Gly Asp 
            20                  25                  30          


Pro Val Glu Leu Ala Lys Arg Tyr Asp Glu Glu Gly Ala Asp Glu Leu 
        35                  40                  45              


Thr Phe Leu Asp Val Thr Ala Ser Lys His Gly Arg Gly Thr Met Leu 
    50                  55                  60                  


Asp Val Val Arg Arg Thr Ala Asp Gln Val Phe Ile Pro Leu Thr Val 
65                  70                  75                  80  


Gly Gly Gly Val Arg Ser Glu Glu Asp Val Asp Gln Leu Leu Arg Ala 
                85                  90                  95      


Gly Ala Asp Lys Val Ser Val Asn Thr Ser Ala Ile Ala Arg Pro Glu 
            100                 105                 110         


Leu Leu Ser Glu Leu Ser Lys Arg Phe Gly Ala Gln Cys Ile Val Leu 
        115                 120                 125             


Ser Val Asp Ala Arg Arg Val Pro Glu Gly Gly Thr Pro Gln Pro Ser 
    130                 135                 140                 


Gly Phe Glu Val Thr Thr His Gly Gly Ser Lys Ser Ala Glu Leu Asp 
145                 150                 155                 160 


Ala Ile Glu Trp Ala Lys Arg Gly Glu Glu Leu Gly Val Gly Glu Ile 
                165                 170                 175     


Leu Leu Asn Ser Met Asp Gly Asp Gly Thr Lys Asn Gly Phe Asp Leu 
            180                 185                 190         


Glu Leu Leu Glu Lys Val Arg Ala Ala Val Ser Ile Pro Val Ile Ala 
        195                 200                 205             


Ser Gly Gly Ala Gly Lys Ala Glu His Phe Pro Pro Ala Val Ala Ala 
    210                 215                 220                 


Gly Ala Asn Ala Val Leu Ala Ala Thr Ile Phe His Phe Arg Glu Val 
225                 230                 235                 240 


Thr Ile Ala Glu Val Lys Gly Ala Ile Lys Asp Ala Gly Phe Glu Val 
                245                 250                 255     


Arg Lys 
        


<210>  18
<211>  211
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  18

Met Thr Lys Thr Val Ala Leu Leu Asp Tyr Gly Ser Gly Asn Leu Arg 
1               5                   10                  15      


Ser Ala Gln Arg Ala Leu Glu Arg Ala Gly Ala Glu Val Thr Val Ser 
            20                  25                  30          


Ser Asp Pro Glu Val Cys Thr Asn Ala Asp Gly Leu Leu Val Pro Gly 
        35                  40                  45              


Val Gly Ala Phe Asp Ala Cys Met Lys Gly Leu Lys Asn Val Phe Gly 
    50                  55                  60                  


His Arg Ile Ile Gly Gln Arg Leu Ala Gly Gly Arg Pro Val Met Gly 
65                  70                  75                  80  


Ile Cys Val Gly Met Gln Ile Leu Phe Asp Glu Gly Asp Glu His Gly 
                85                  90                  95      


Ile Lys Ser Ala Gly Cys Gly Glu Trp Pro Gly Lys Val Glu Arg Leu 
            100                 105                 110         


Gln Ala Glu Ile Leu Pro His Met Gly Trp Asn Thr Leu Glu Met Pro 
        115                 120                 125             


Thr Asn Ser Pro Met Phe Glu Gly Ile Ser Pro Asp Glu Arg Phe Tyr 
    130                 135                 140                 


Phe Val His Ser Tyr Gly Val Arg Lys Trp Thr Leu Glu Thr Asp Asp 
145                 150                 155                 160 


Leu Thr Thr Pro Pro Glu Val Val Trp Ala Lys His Glu Asn Asp Arg 
                165                 170                 175     


Phe Val Ala Ala Val Glu Asn Gly Thr Leu Trp Ala Thr Gln Phe His 
            180                 185                 190         


Pro Glu Lys Ser Gly Asp Val Gly Ala Lys Leu Leu Arg Asn Trp Ile 
        195                 200                 205             


Asn Tyr Ile 
    210     


<210>  19
<211>  118
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  19

Met Ser Asp Asn Pro Gln Glu Tyr Glu Leu Asp Trp Asp Val Glu Lys 
1               5                   10                  15      


Arg Leu Lys Leu Asn Asp Ala Gly Leu Val Pro Ala Ile Val Gln Ala 
            20                  25                  30          


Asp Gly Thr Asn Glu Val Leu Met Met Ala Trp Met Asp Thr His Ala 
        35                  40                  45              


Leu Ala Tyr Thr Leu Ala Thr Arg Arg Gly Thr Tyr Phe Ser Arg Ser 
    50                  55                  60                  


Arg Asn Glu Tyr Trp Ile Lys Gly Leu Thr Ser Gly Asn Val Gln Glu 
65                  70                  75                  80  


Val Thr Gly Leu Ala Leu Asp Cys Asp Gly Asp Thr Val Leu Leu Thr 
                85                  90                  95      


Val Lys Gln Thr Gly Gly Ala Cys His Thr Gly Ala His Thr Cys Phe 
            100                 105                 110         


Asp Asn Asp Val Leu Leu 
        115             


<210>  20
<211>  799
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Val Leu Pro Ile Leu Pro Leu Ile Asp Asp Leu Ala Ser Trp Asn 
1               5                   10                  15      


Ser Lys Lys Glu Tyr Val Ser Leu Val Gly Gln Val Leu Leu Asp Gly 
            20                  25                  30          


Ser Ser Leu Ser Asn Glu Glu Ile Leu Gln Phe Ser Lys Glu Glu Glu 
        35                  40                  45              


Val Pro Leu Val Ala Leu Ser Leu Pro Ser Gly Lys Phe Ser Asp Asp 
    50                  55                  60                  


Glu Ile Ile Ala Phe Leu Asn Asn Gly Val Ser Ser Leu Phe Ile Ala 
65                  70                  75                  80  


Ser Gln Asp Ala Lys Thr Ala Glu His Leu Val Glu Gln Leu Asn Val 
                85                  90                  95      


Pro Lys Glu Arg Val Val Val Glu Glu Asn Gly Val Phe Ser Asn Gln 
            100                 105                 110         


Phe Met Val Lys Gln Lys Phe Ser Gln Asp Lys Ile Val Ser Ile Lys 
        115                 120                 125             


Lys Leu Ser Lys Asp Met Leu Thr Lys Glu Val Leu Gly Glu Val Arg 
    130                 135                 140                 


Thr Asp Arg Pro Asp Gly Leu Tyr Thr Thr Leu Val Val Asp Gln Tyr 
145                 150                 155                 160 


Glu Arg Cys Leu Gly Leu Val Tyr Ser Ser Lys Lys Ser Ile Ala Lys 
                165                 170                 175     


Ala Ile Asp Leu Gly Arg Gly Val Tyr Tyr Ser Arg Ser Arg Asn Glu 
            180                 185                 190         


Ile Trp Ile Lys Gly Glu Thr Ser Gly Asn Gly Gln Lys Leu Leu Gln 
        195                 200                 205             


Ile Ser Thr Asp Cys Asp Ser Asp Ala Leu Lys Phe Ile Val Glu Gln 
    210                 215                 220                 


Glu Asn Val Gly Phe Cys His Leu Glu Thr Met Ser Cys Phe Gly Glu 
225                 230                 235                 240 


Phe Lys His Gly Leu Val Gly Leu Glu Ser Leu Leu Lys Gln Arg Leu 
                245                 250                 255     


Gln Asp Ala Pro Glu Glu Ser Tyr Thr Arg Arg Leu Phe Asn Asp Ser 
            260                 265                 270         


Ala Leu Leu Asp Ala Lys Ile Lys Glu Glu Ala Glu Glu Leu Thr Glu 
        275                 280                 285             


Ala Lys Gly Lys Lys Glu Leu Ser Trp Glu Ala Ala Asp Leu Phe Tyr 
    290                 295                 300                 


Phe Ala Leu Ala Lys Leu Val Ala Asn Asp Val Ser Leu Lys Asp Val 
305                 310                 315                 320 


Glu Asn Asn Leu Asn Met Lys His Leu Lys Val Thr Arg Arg Lys Gly 
                325                 330                 335     


Asp Ala Lys Pro Lys Phe Val Gly Gln Pro Lys Ala Glu Glu Glu Lys 
            340                 345                 350         


Leu Thr Gly Pro Ile His Leu Asp Val Val Lys Ala Ser Asp Lys Val 
        355                 360                 365             


Gly Val Gln Lys Ala Leu Ser Arg Pro Ile Gln Lys Thr Ser Glu Ile 
    370                 375                 380                 


Met His Leu Val Asn Pro Ile Ile Glu Asn Val Arg Asp Lys Gly Asn 
385                 390                 395                 400 


Ser Ala Leu Leu Glu Tyr Thr Glu Lys Phe Asp Gly Val Lys Leu Ser 
                405                 410                 415     


Asn Pro Val Leu Asn Ala Pro Phe Pro Glu Glu Tyr Phe Glu Gly Leu 
            420                 425                 430         


Thr Glu Glu Met Lys Glu Ala Leu Asp Leu Ser Ile Glu Asn Val Arg 
        435                 440                 445             


Lys Phe His Ala Ala Gln Leu Pro Thr Glu Thr Leu Glu Val Glu Thr 
    450                 455                 460                 


Gln Pro Gly Val Leu Cys Ser Arg Phe Pro Arg Pro Ile Glu Lys Val 
465                 470                 475                 480 


Gly Leu Tyr Ile Pro Gly Gly Thr Ala Ile Leu Pro Ser Thr Ala Leu 
                485                 490                 495     


Met Leu Gly Val Pro Ala Gln Val Ala Gln Cys Lys Glu Ile Val Phe 
            500                 505                 510         


Ala Ser Pro Pro Arg Lys Ser Asp Gly Lys Val Ser Pro Glu Val Val 
        515                 520                 525             


Tyr Val Ala Glu Lys Val Gly Ala Ser Lys Ile Val Leu Ala Gly Gly 
    530                 535                 540                 


Ala Gln Ala Val Ala Ala Met Ala Tyr Gly Thr Glu Thr Ile Pro Lys 
545                 550                 555                 560 


Val Asp Lys Ile Leu Gly Pro Gly Asn Gln Phe Val Thr Ala Ala Lys 
                565                 570                 575     


Met Tyr Val Gln Asn Asp Thr Gln Ala Leu Cys Ser Ile Asp Met Pro 
            580                 585                 590         


Ala Gly Pro Ser Glu Val Leu Val Ile Ala Asp Glu Asp Ala Asp Val 
        595                 600                 605             


Asp Phe Val Ala Ser Asp Leu Leu Ser Gln Ala Glu His Gly Ile Asp 
    610                 615                 620                 


Ser Gln Val Ile Leu Val Gly Val Asn Leu Ser Glu Lys Lys Ile Gln 
625                 630                 635                 640 


Glu Ile Gln Asp Ala Val His Asn Gln Ala Leu Gln Leu Pro Arg Val 
                645                 650                 655     


Asp Ile Val Arg Lys Cys Ile Ala His Ser Thr Ile Val Leu Cys Asp 
            660                 665                 670         


Gly Tyr Glu Glu Ala Leu Glu Met Ser Asn Gln Tyr Ala Pro Glu His 
        675                 680                 685             


Leu Ile Leu Gln Ile Ala Asn Ala Asn Asp Tyr Val Lys Leu Val Asp 
    690                 695                 700                 


Asn Ala Gly Ser Val Phe Val Gly Ala Tyr Thr Pro Glu Ser Cys Gly 
705                 710                 715                 720 


Asp Tyr Ser Ser Gly Thr Asn His Thr Leu Pro Thr Tyr Gly Tyr Ala 
                725                 730                 735     


Arg Gln Tyr Ser Gly Ala Asn Thr Ala Thr Phe Gln Lys Phe Ile Thr 
            740                 745                 750         


Ala Gln Asn Ile Thr Pro Glu Gly Leu Glu Asn Ile Gly Arg Ala Val 
        755                 760                 765             


Met Cys Val Ala Lys Lys Glu Gly Leu Asp Gly His Arg Asn Ala Val 
    770                 775                 780                 


Lys Ile Arg Met Ser Lys Leu Gly Leu Ile Pro Lys Asp Phe Gln 
785                 790                 795                 


<210>  21
<211>  552
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Pro Val Val His Val Ile Asp Val Glu Ser Gly Asn Leu Gln Ser 
1               5                   10                  15      


Leu Thr Asn Ala Ile Glu His Leu Gly Tyr Glu Val Gln Leu Val Lys 
            20                  25                  30          


Ser Pro Lys Asp Phe Asn Ile Ser Gly Thr Ser Arg Leu Ile Leu Pro 
        35                  40                  45              


Gly Val Gly Asn Tyr Gly His Phe Val Asp Asn Leu Phe Asn Arg Gly 
    50                  55                  60                  


Phe Glu Lys Pro Ile Arg Glu Tyr Ile Glu Ser Gly Lys Pro Ile Met 
65                  70                  75                  80  


Gly Ile Cys Val Gly Leu Gln Ala Leu Phe Ala Gly Ser Val Glu Ser 
                85                  90                  95      


Pro Lys Ser Thr Gly Leu Asn Tyr Ile Asp Phe Lys Leu Ser Arg Phe 
            100                 105                 110         


Asp Asp Ser Glu Lys Pro Val Pro Glu Ile Gly Trp Asn Ser Cys Ile 
        115                 120                 125             


Pro Ser Glu Asn Leu Phe Phe Gly Leu Asp Pro Tyr Lys Arg Tyr Tyr 
    130                 135                 140                 


Phe Val His Ser Phe Ala Ala Ile Leu Asn Ser Glu Lys Lys Lys Asn 
145                 150                 155                 160 


Leu Glu Asn Asp Gly Trp Lys Ile Ala Lys Ala Lys Tyr Gly Ser Glu 
                165                 170                 175     


Glu Phe Ile Ala Ala Val Asn Lys Asn Asn Ile Phe Ala Thr Gln Phe 
            180                 185                 190         


His Pro Glu Lys Ser Gly Lys Ala Gly Leu Asn Val Ile Glu Asn Phe 
        195                 200                 205             


Leu Lys Gln Gln Ser Pro Pro Ile Pro Asn Tyr Ser Ala Glu Glu Lys 
    210                 215                 220                 


Glu Leu Leu Met Asn Asp Tyr Ser Asn Tyr Gly Leu Thr Arg Arg Ile 
225                 230                 235                 240 


Ile Ala Cys Leu Asp Val Arg Thr Asn Asp Gln Gly Asp Leu Val Val 
                245                 250                 255     


Thr Lys Gly Asp Gln Tyr Asp Val Arg Glu Lys Ser Asp Gly Lys Gly 
            260                 265                 270         


Val Arg Asn Leu Gly Lys Pro Val Gln Leu Ala Gln Lys Tyr Tyr Gln 
        275                 280                 285             


Gln Gly Ala Asp Glu Val Thr Phe Leu Asn Ile Thr Ser Phe Arg Asp 
    290                 295                 300                 


Cys Pro Leu Lys Asp Thr Pro Met Leu Glu Val Leu Lys Gln Ala Ala 
305                 310                 315                 320 


Lys Thr Val Phe Val Pro Leu Thr Val Gly Gly Gly Ile Lys Asp Ile 
                325                 330                 335     


Val Asp Val Asp Gly Thr Lys Ile Pro Ala Leu Glu Val Ala Ser Leu 
            340                 345                 350         


Tyr Phe Arg Ser Gly Ala Asp Lys Val Ser Ile Gly Thr Asp Ala Val 
        355                 360                 365             


Tyr Ala Ala Glu Lys Tyr Tyr Glu Leu Gly Asn Arg Gly Asp Gly Thr 
    370                 375                 380                 


Ser Pro Ile Glu Thr Ile Ser Lys Ala Tyr Gly Ala Gln Ala Val Val 
385                 390                 395                 400 


Ile Ser Val Asp Pro Lys Arg Val Tyr Val Asn Ser Gln Ala Asp Thr 
                405                 410                 415     


Lys Asn Lys Val Phe Glu Thr Glu Tyr Pro Gly Pro Asn Gly Glu Lys 
            420                 425                 430         


Tyr Cys Trp Tyr Gln Cys Thr Ile Lys Gly Gly Arg Glu Ser Arg Asp 
        435                 440                 445             


Leu Gly Val Trp Glu Leu Thr Arg Ala Cys Glu Ala Leu Gly Ala Gly 
    450                 455                 460                 


Glu Ile Leu Leu Asn Cys Ile Asp Lys Asp Gly Ser Asn Ser Gly Tyr 
465                 470                 475                 480 


Asp Leu Glu Leu Ile Glu His Val Lys Asp Ala Val Lys Ile Pro Val 
                485                 490                 495     


Ile Ala Ser Ser Gly Ala Gly Val Pro Glu His Phe Glu Glu Ala Phe 
            500                 505                 510         


Leu Lys Thr Arg Ala Asp Ala Cys Leu Gly Ala Gly Met Phe His Arg 
        515                 520                 525             


Gly Glu Phe Thr Val Asn Asp Val Lys Glu Tyr Leu Leu Glu His Gly 
    530                 535                 540                 


Leu Lys Val Arg Met Asp Glu Glu 
545                 550         


<210>  22
<211>  281
<212>  PRT
<213>  Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

<400>  22

Met Leu Lys Ile Ala Val Pro Asn Lys Gly Ser Leu Ser Glu Arg Ala 
1               5                   10                  15      


Met Glu Ile Leu Ala Glu Ala Gly Tyr Ala Gly Arg Gly Asp Ser Lys 
            20                  25                  30          


Ser Leu Asn Val Phe Asp Glu Ala Asn Asn Val Glu Phe Phe Phe Leu 
        35                  40                  45              


Arg Pro Lys Asp Ile Ala Ile Tyr Val Ala Gly Gly Gln Leu Asp Leu 
    50                  55                  60                  


Gly Ile Thr Gly Arg Asp Leu Ala Arg Asp Ser Gln Ala Asp Val His 
65                  70                  75                  80  


Glu Val Leu Ser Leu Gly Phe Gly Ser Ser Thr Phe Arg Tyr Ala Ala 
                85                  90                  95      


Pro Ala Asp Glu Glu Trp Ser Ile Glu Lys Leu Asp Gly Lys Arg Ile 
            100                 105                 110         


Ala Thr Ser Tyr Pro Asn Leu Val Arg Asp Asp Leu Ala Ala Arg Gly 
        115                 120                 125             


Leu Ser Ala Glu Val Leu Arg Leu Asp Gly Ala Val Glu Val Ser Ile 
    130                 135                 140                 


Lys Leu Gly Val Ala Asp Ala Ile Ala Asp Val Val Ser Thr Gly Arg 
145                 150                 155                 160 


Thr Leu Arg Gln Gln Gly Leu Ala Pro Phe Gly Glu Val Leu Cys Thr 
                165                 170                 175     


Ser Glu Ala Val Ile Val Gly Arg Lys Asp Glu Lys Val Thr Pro Glu 
            180                 185                 190         


Gln Gln Ile Leu Leu Arg Arg Ile Gln Gly Ile Leu His Ala Gln Asn 
        195                 200                 205             


Phe Leu Met Leu Asp Tyr Lys Val Asp Arg Asp Asn Leu Asp Ala Ala 
    210                 215                 220                 


Thr Ala Val Thr Pro Gly Phe Ser Gly Pro Ala Val Ser Pro Leu Ala 
225                 230                 235                 240 


Arg Asp Asn Trp Val Ala Val Arg Ala Met Val Pro Arg Arg Ser Ala 
                245                 250                 255     


Asn Ala Ile Met Asp Lys Leu Ala Gly Leu Gly Ala Glu Ala Ile Leu 
            260                 265                 270         


Ala Ser Glu Ile Arg Ile Ala Arg Ile 
        275                 280     


<210>  23
<211>  385
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Val Phe Asp Leu Lys Arg Ile Val Arg Pro Lys Ile Tyr Asn Leu 
1               5                   10                  15      


Glu Pro Tyr Arg Cys Ala Arg Asp Asp Phe Thr Glu Gly Ile Leu Leu 
            20                  25                  30          


Asp Ala Asn Glu Asn Ala His Gly Pro Thr Pro Val Glu Leu Ser Lys 
        35                  40                  45              


Thr Asn Leu His Arg Tyr Pro Asp Pro His Gln Leu Glu Phe Lys Thr 
    50                  55                  60                  


Ala Met Thr Lys Tyr Arg Asn Lys Thr Ser Ser Tyr Ala Asn Asp Pro 
65                  70                  75                  80  


Glu Val Lys Pro Leu Thr Ala Asp Asn Leu Cys Leu Gly Val Gly Ser 
                85                  90                  95      


Asp Glu Ser Ile Asp Ala Ile Ile Arg Ala Cys Cys Val Pro Gly Lys 
            100                 105                 110         


Glu Lys Ile Leu Val Leu Pro Pro Thr Tyr Ser Met Tyr Ser Val Cys 
        115                 120                 125             


Ala Asn Ile Asn Asp Ile Glu Val Val Gln Cys Pro Leu Thr Val Ser 
    130                 135                 140                 


Asp Gly Ser Phe Gln Met Asp Thr Glu Ala Val Leu Thr Ile Leu Lys 
145                 150                 155                 160 


Asn Asp Ser Leu Ile Lys Leu Met Phe Val Thr Ser Pro Gly Asn Pro 
                165                 170                 175     


Thr Gly Ala Lys Ile Lys Thr Ser Leu Ile Glu Lys Val Leu Gln Asn 
            180                 185                 190         


Trp Asp Asn Gly Leu Val Val Val Asp Glu Ala Tyr Val Asp Phe Cys 
        195                 200                 205             


Gly Gly Ser Thr Ala Pro Leu Val Thr Lys Tyr Pro Asn Leu Val Thr 
    210                 215                 220                 


Leu Gln Thr Leu Ser Lys Ser Phe Gly Leu Ala Gly Ile Arg Leu Gly 
225                 230                 235                 240 


Met Thr Tyr Ala Thr Ala Glu Leu Ala Arg Ile Leu Asn Ala Met Lys 
                245                 250                 255     


Ala Pro Tyr Asn Ile Ser Ser Leu Ala Ser Glu Tyr Ala Leu Lys Ala 
            260                 265                 270         


Val Gln Asp Ser Asn Leu Lys Lys Met Glu Ala Thr Ser Lys Ile Ile 
        275                 280                 285             


Asn Glu Glu Lys Met Arg Leu Leu Lys Glu Leu Thr Ala Leu Asp Tyr 
    290                 295                 300                 


Val Asp Asp Gln Tyr Val Gly Gly Leu Asp Ala Asn Phe Leu Leu Ile 
305                 310                 315                 320 


Arg Ile Asn Gly Gly Asp Asn Val Leu Ala Lys Lys Leu Tyr Tyr Gln 
                325                 330                 335     


Leu Ala Thr Gln Ser Gly Val Val Val Arg Phe Arg Gly Asn Glu Leu 
            340                 345                 350         


Gly Cys Ser Gly Cys Leu Arg Ile Thr Val Gly Thr His Glu Glu Asn 
        355                 360                 365             


Thr His Leu Ile Lys Tyr Phe Lys Glu Thr Leu Tyr Lys Leu Ala Asn 
    370                 375                 380                 


Glu 
385 


<210>  24
<211>  220
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Thr Glu Gln Lys Ala Leu Val Lys Arg Ile Thr Asn Glu Thr Lys 
1               5                   10                  15      


Ile Gln Ile Ala Ile Ser Leu Lys Gly Gly Pro Leu Ala Ile Glu His 
            20                  25                  30          


Ser Ile Phe Pro Glu Lys Glu Ala Glu Ala Val Ala Glu Gln Ala Thr 
        35                  40                  45              


Gln Ser Gln Val Ile Asn Val His Thr Gly Ile Gly Phe Leu Asp His 
    50                  55                  60                  


Met Ile His Ala Leu Ala Lys His Ser Gly Trp Ser Leu Ile Val Glu 
65                  70                  75                  80  


Cys Ile Gly Asp Leu His Ile Asp Asp His His Thr Thr Glu Asp Cys 
                85                  90                  95      


Gly Ile Ala Leu Gly Gln Ala Phe Lys Glu Ala Leu Gly Ala Val Arg 
            100                 105                 110         


Gly Val Lys Arg Phe Gly Ser Gly Phe Ala Pro Leu Asp Glu Ala Leu 
        115                 120                 125             


Ser Arg Ala Val Val Asp Leu Ser Asn Arg Pro Tyr Ala Val Val Glu 
    130                 135                 140                 


Leu Gly Leu Gln Arg Glu Lys Val Gly Asp Leu Ser Cys Glu Met Ile 
145                 150                 155                 160 


Pro His Phe Leu Glu Ser Phe Ala Glu Ala Ser Arg Ile Thr Leu His 
                165                 170                 175     


Val Asp Cys Leu Arg Gly Lys Asn Asp His His Arg Ser Glu Ser Ala 
            180                 185                 190         


Phe Lys Ala Leu Ala Val Ala Ile Arg Glu Ala Thr Ser Pro Asn Gly 
        195                 200                 205             


Thr Asn Asp Val Pro Ser Thr Lys Gly Val Leu Met 
    210                 215                 220 


<210>  25
<211>  335
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met His Ser His His Ser His Ser Gly Asp Tyr Ser Ala His Gly Thr 
1               5                   10                  15      


Asp Pro Leu Asp Ser Val Val Asp Gln Val Val Asn Leu Asn Phe His 
            20                  25                  30          


Thr Tyr Cys Leu Thr Glu His Ile Pro Arg Ile Glu Ala Lys Phe Ile 
        35                  40                  45              


Tyr Pro Glu Glu Gln Ser Leu Gly Lys Asn Pro Glu Glu Val Ile Ser 
    50                  55                  60                  


Lys Leu Glu Thr Ser Phe Lys Asn Phe Met Ser His Ala Gln Glu Ile 
65                  70                  75                  80  


Lys Thr Arg Tyr Ala Asp Arg Pro Asp Val Arg Thr Lys Phe Ile Ile 
                85                  90                  95      


Gly Met Glu Ile Glu Ser Cys Asp Met Ala His Ile Glu Tyr Ala Lys 
            100                 105                 110         


Arg Leu Met Lys Glu Asn Asn Asp Thr Leu Lys Phe Cys Val Gly Ser 
        115                 120                 125             


Val His His Val Asn Gly Ile Pro Ile Asp Phe Asp Gln Gln Gln Trp 
    130                 135                 140                 


Tyr Asn Ser Leu His Ser Phe Asn Asp Asn Leu Lys Asp Phe Leu Leu 
145                 150                 155                 160 


Ser Tyr Phe Gln Ser Gln Tyr Glu Met Leu Ile Asn Ile Lys Pro Leu 
                165                 170                 175     


Val Val Gly His Phe Asp Leu Tyr Lys Leu Phe Leu Pro Asn Asp Met 
            180                 185                 190         


Leu Val Asn Gln Lys Ser Gly Asn Cys Asn Glu Glu Thr Gly Val Pro 
        195                 200                 205             


Val Ala Ser Leu Asp Val Ile Ser Glu Trp Pro Glu Ile Tyr Asp Ala 
    210                 215                 220                 


Val Val Arg Asn Leu Gln Phe Ile Asp Ser Tyr Gly Gly Ala Ile Glu 
225                 230                 235                 240 


Ile Asn Thr Ser Ala Leu Arg Lys Gly Leu Glu Glu Pro Tyr Pro Ser 
                245                 250                 255     


Lys Thr Leu Cys Asn Leu Val Lys Lys His Cys Gly Ser Arg Phe Val 
            260                 265                 270         


Leu Ser Asp Asp Ala His Gly Val Ala Gln Val Gly Val Cys Tyr Asp 
        275                 280                 285             


Lys Val Lys Lys Tyr Ile Val Asp Val Leu Gln Leu Glu Tyr Ile Cys 
    290                 295                 300                 


Tyr Leu Glu Glu Ser Gln Ser Pro Glu Asn Val Leu Thr Val Lys Arg 
305                 310                 315                 320 


Leu Pro Ile Ser Gln Phe Val Asn Asp Pro Phe Trp Ala Asn Ile 
                325                 330                 335 


<210>  26
<211>  514
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  26

Met Ser Thr Asn Thr Thr Pro Ser Ser Trp Thr Asn Pro Leu Arg Asp 
1               5                   10                  15      


Pro Gln Asp Lys Arg Leu Pro Arg Ile Ala Gly Pro Ser Gly Met Val 
            20                  25                  30          


Ile Phe Gly Val Thr Gly Asp Leu Ala Arg Lys Lys Leu Leu Pro Ala 
        35                  40                  45              


Ile Tyr Asp Leu Ala Asn Arg Gly Leu Leu Pro Pro Gly Phe Ser Leu 
    50                  55                  60                  


Val Gly Tyr Gly Arg Arg Glu Trp Ser Lys Glu Asp Phe Glu Lys Tyr 
65                  70                  75                  80  


Val Arg Asp Ala Ala Ser Ala Gly Ala Arg Thr Glu Phe Arg Glu Asn 
                85                  90                  95      


Val Trp Glu Arg Leu Ala Glu Gly Met Glu Phe Val Arg Gly Asn Phe 
            100                 105                 110         


Asp Asp Asp Ala Ala Phe Asp Asn Leu Ala Ala Thr Leu Lys Arg Ile 
        115                 120                 125             


Asp Lys Thr Arg Gly Thr Ala Gly Asn Trp Ala Tyr Tyr Leu Ser Ile 
    130                 135                 140                 


Pro Pro Asp Ser Phe Ala Ala Val Cys His Gln Leu Glu Arg Ser Gly 
145                 150                 155                 160 


Met Ala Glu Ser Thr Glu Glu Ala Trp Arg Arg Val Ile Ile Glu Lys 
                165                 170                 175     


Pro Phe Gly His Asn Leu Glu Ser Ala His Glu Leu Asn Gln Leu Val 
            180                 185                 190         


Asn Ala Val Phe Pro Glu Ser Ser Val Phe Arg Ile Asp His Tyr Leu 
        195                 200                 205             


Gly Lys Glu Thr Val Gln Asn Ile Leu Ala Leu Arg Phe Ala Asn Gln 
    210                 215                 220                 


Leu Phe Glu Pro Leu Trp Asn Ser Asn Tyr Val Asp His Val Gln Ile 
225                 230                 235                 240 


Thr Met Thr Glu Asp Ile Gly Leu Gly Gly Arg Ala Gly Tyr Tyr Asp 
                245                 250                 255     


Gly Ile Gly Ala Ala Arg Asp Val Ile Gln Asn His Leu Ile Gln Leu 
            260                 265                 270         


Leu Ala Leu Val Ala Met Glu Glu Pro Ile Ser Phe Val Pro Ala Gln 
        275                 280                 285             


Leu Gln Ala Glu Lys Ile Lys Val Leu Ser Ala Thr Lys Pro Cys Tyr 
    290                 295                 300                 


Pro Leu Asp Lys Thr Ser Ala Arg Gly Gln Tyr Ala Ala Gly Trp Gln 
305                 310                 315                 320 


Gly Ser Glu Leu Val Lys Gly Leu Arg Glu Glu Asp Gly Phe Asn Pro 
                325                 330                 335     


Glu Ser Thr Thr Glu Thr Phe Ala Ala Cys Thr Leu Glu Ile Thr Ser 
            340                 345                 350         


Arg Arg Trp Ala Gly Val Pro Phe Tyr Leu Arg Thr Gly Lys Arg Leu 
        355                 360                 365             


Gly Arg Arg Val Thr Glu Ile Ala Val Val Phe Lys Asp Ala Pro His 
    370                 375                 380                 


Gln Pro Phe Asp Gly Asp Met Thr Val Ser Leu Gly Gln Asn Ala Ile 
385                 390                 395                 400 


Val Ile Arg Val Gln Pro Asp Glu Gly Val Leu Ile Arg Phe Gly Ser 
                405                 410                 415     


Lys Val Pro Gly Ser Ala Met Glu Val Arg Asp Val Asn Met Asp Phe 
            420                 425                 430         


Ser Tyr Ser Glu Ser Phe Thr Glu Glu Ser Pro Glu Ala Tyr Glu Arg 
        435                 440                 445             


Leu Ile Leu Asp Ala Leu Leu Asp Glu Ser Ser Leu Phe Pro Thr Asn 
    450                 455                 460                 


Glu Glu Val Glu Leu Ser Trp Lys Ile Leu Asp Pro Ile Leu Glu Ala 
465                 470                 475                 480 


Trp Asp Ala Asp Gly Glu Pro Glu Asp Tyr Pro Ala Gly Thr Trp Gly 
                485                 490                 495     


Pro Lys Ser Ala Asp Glu Met Leu Ser Arg Asn Gly His Thr Trp Arg 
            500                 505                 510         


Arg Pro 
        


<210>  27
<211>  680
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  27

Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg 
1               5                   10                  15      


Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly 
            20                  25                  30          


Ala Pro Leu Gly Met Ala Pro Ala Ala His Val Leu Trp Ser Gln Met 
        35                  40                  45              


Arg Met Asn Pro Thr Asn Pro Asp Trp Ile Asn Arg Asp Arg Phe Val 
    50                  55                  60                  


Leu Ser Asn Gly His Ala Val Ala Leu Leu Tyr Ser Met Leu His Leu 
65                  70                  75                  80  


Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu 
                85                  90                  95      


Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu 
            100                 105                 110         


Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met 
        115                 120                 125             


Ala Met Ala Gln Ala Asn Leu Ala Ala Thr Tyr Asn Lys Pro Gly Phe 
    130                 135                 140                 


Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys Leu 
145                 150                 155                 160 


Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu Lys 
                165                 170                 175     


Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile Asp 
            180                 185                 190         


Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr Glu 
        195                 200                 205             


Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp Leu 
    210                 215                 220                 


Ala Gly Ile Ala Lys Ala Ile Ala Gln Ala Lys Leu Ser Lys Asp Lys 
225                 230                 235                 240 


Pro Thr Leu Ile Lys Met Thr Thr Thr Ile Gly Tyr Gly Ser Leu His 
                245                 250                 255     


Ala Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp Val 
            260                 265                 270         


Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe Val 
        275                 280                 285             


Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys Pro 
    290                 295                 300                 


Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr Gln 
305                 310                 315                 320 


Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser Gly 
                325                 330                 335     


Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala Lys 
            340                 345                 350         


Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu Asp 
        355                 360                 365             


Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu Thr 
    370                 375                 380                 


Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala Leu Asp Phe Gln Pro Pro 
385                 390                 395                 400 


Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg Tyr Ile Arg Tyr Gly Ile 
                405                 410                 415     


Arg Glu His Ala Met Gly Ala Ile Met Asn Gly Ile Ser Ala Phe Gly 
            420                 425                 430         


Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe Leu Asn Phe Val Ser Tyr 
        435                 440                 445             


Ala Ala Gly Ala Val Arg Leu Ser Ala Leu Ser Gly His Pro Val Ile 
    450                 455                 460                 


Trp Val Ala Thr His Asp Ser Ile Gly Val Gly Glu Asp Gly Pro Thr 
465                 470                 475                 480 


His Gln Pro Ile Glu Thr Leu Ala His Phe Arg Ser Leu Pro Asn Ile 
                485                 490                 495     


Gln Val Trp Arg Pro Ala Asp Gly Asn Glu Val Ser Ala Ala Tyr Lys 
            500                 505                 510         


Asn Ser Leu Glu Ser Lys His Thr Pro Ser Ile Ile Ala Leu Ser Arg 
        515                 520                 525             


Gln Asn Leu Pro Gln Leu Glu Gly Ser Ser Ile Glu Ser Ala Ser Lys 
    530                 535                 540                 


Gly Gly Tyr Val Leu Gln Asp Val Ala Asn Pro Asp Ile Ile Leu Val 
545                 550                 555                 560 


Ala Thr Gly Ser Glu Val Ser Leu Ser Val Glu Ala Ala Lys Thr Leu 
                565                 570                 575     


Ala Ala Lys Asn Ile Lys Ala Arg Val Val Ser Leu Pro Asp Phe Phe 
            580                 585                 590         


Thr Phe Asp Lys Gln Pro Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp 
        595                 600                 605             


Asn Val Pro Ile Met Ser Val Glu Val Leu Ala Thr Thr Cys Trp Gly 
    610                 615                 620                 


Lys Tyr Ala His Gln Ser Phe Gly Ile Asp Arg Phe Gly Ala Ser Gly 
625                 630                 635                 640 


Lys Ala Pro Glu Val Phe Lys Phe Phe Gly Phe Thr Pro Glu Gly Val 
                645                 650                 655     


Ala Glu Arg Ala Gln Lys Thr Ile Ala Phe Tyr Lys Gly Asp Lys Leu 
            660                 665                 670         


Ile Ser Pro Leu Lys Lys Ala Phe 
        675                 680 


<210>  28
<211>  496
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  28

Met Ser Met Ser Asn Ile Val Val Phe Gly Gly Asp Ser His Pro Glu 
1               5                   10                  15      


Leu Val Thr Lys Ile Cys Glu Asn Leu Asp Ile His Pro Ser Lys Val 
            20                  25                  30          


Glu Leu Gly Lys Phe Ser Asn Gly Glu Thr Asn Ile Ala Leu Arg Glu 
        35                  40                  45              


Ser Val Arg Glu Lys Asp Val Tyr Ile Ile Gln Ser Gly Cys Gly Gln 
    50                  55                  60                  


Val Asn Asp Thr Phe Met Gln Leu Leu Ile Leu Ile Ser Ala Cys Lys 
65                  70                  75                  80  


Ser Ala Ser Ala Ser Arg Val Thr Ala Val Met Pro Tyr Leu Cys Tyr 
                85                  90                  95      


Ser Arg Gln Pro Asp Ile Pro Tyr Thr Ala Lys Gly Ala Pro Ile Ile 
            100                 105                 110         


Ser Lys Pro Lys Glu Asn Tyr Thr Phe Glu Ser His Pro Gly Thr Pro 
        115                 120                 125             


Val Ser Ser Ser Leu Met Thr Gln Arg Pro Gly Ala Glu Ser Ser Leu 
    130                 135                 140                 


Lys Ser Leu Asp Ser Ala Ile Arg Ser Thr Ile Asn Leu Glu Asn Pro 
145                 150                 155                 160 


Gln Pro Ile Arg Thr Pro Asn Ser Ser Ala Thr Ala Asn Asn Asn Phe 
                165                 170                 175     


Asp Ile Lys Lys Thr Leu Ser Phe Ser Arg Ile Pro Met Ile Pro Gly 
            180                 185                 190         


Gly Lys Leu Gln Asn Thr Ser Asn Ser Thr Asp Ala Gly Glu Leu Phe 
        195                 200                 205             


Asn Ala Gln Asn Ala Gly Tyr Lys Leu Trp Val Val Gln Ala Gly Thr 
    210                 215                 220                 


Leu Ile Ala His Leu Leu Ser Ala Ala Gly Ala Asp His Val Ile Thr 
225                 230                 235                 240 


Met Asp Leu His Asp Pro Gln Phe Pro Gly Phe Phe Asp Ile Pro Val 
                245                 250                 255     


Asp Asn Leu Tyr Cys Lys Pro Ile Ala Gln Asn Tyr Ile Gln His Arg 
            260                 265                 270         


Ile Pro Asp Tyr Gln Asp Ala Val Ile Val Ser Pro Asp Ala Gly Gly 
        275                 280                 285             


Ala Lys Arg Ala Thr Ala Ile Ala Asp Ala Leu Glu Leu Ser Phe Ala 
    290                 295                 300                 


Leu Ile His Lys Glu Arg Arg Ser Gln Leu Leu Lys Gly Pro Pro Asp 
305                 310                 315                 320 


Ala Thr Leu Thr Ser Gly Gly Ser Leu Pro Val Ser Pro Arg Pro Leu 
                325                 330                 335     


Val Thr Thr Leu Val Ser Ser Gln Asn Thr Thr Ser Ser Gly Ala Thr 
            340                 345                 350         


Gly Val Ala Ala Leu Glu Met Lys Lys Thr Thr Ser Thr Ser Ser Thr 
        355                 360                 365             


Ser Ser Gln Ser Ser Asn Ser Ser Lys Phe Val Gln Thr Thr Met Leu 
    370                 375                 380                 


Val Gly Asp Val Arg Asn Lys Val Cys Ile Ile Val Asp Asp Leu Val 
385                 390                 395                 400 


Asp Thr Ser Tyr Thr Ile Thr Arg Ala Ala Lys Leu Leu Lys Asp Gln 
                405                 410                 415     


Gly Ser Thr Lys Val Tyr Ala Leu Ile Thr His Gly Val Phe Ser Gly 
            420                 425                 430         


Asp Ala Leu Glu Arg Ile Gly Gln Ser Ser Ile Asp Lys Leu Ile Ile 
        435                 440                 445             


Ser Asn Thr Val Pro Gln Asp Arg Thr Leu Gln Tyr Leu Gly Lys Asp 
    450                 455                 460                 


Arg Val Asp Val Ile Asp Val Ser Cys Ile Ile Gly Glu Ala Ile Arg 
465                 470                 475                 480 


Arg Ile His Asn Gly Glu Ser Ile Ser Met Leu Phe Glu His Gly Trp 
                485                 490                 495     


<210>  29
<211>  2397
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  29
atggttttgc cgattctacc gttaattgat gatctggcct catggaatag taagaaggaa       60

tacgtttcac ttgttggtca ggtacttttg gatggctcga gcctgagtaa tgaagagatt      120

ctccagttct ccaaagagga agaagttcca ttggtggctt tgtccttgcc aagtggtaaa      180

ttcagcgatg atgaaatcat tgccttcttg aacaacggag tttcttctct gttcattgct      240

agccaagatg ctaaaacagc cgaacacttg gttgaacaat tgaatgtacc aaaggagcgt      300

gttgttgtgg aagagaacgg tgttttctcc aatcaattca tggtaaaaca aaaattctcg      360

caagataaaa ttgtgtccat aaagaaatta agcaaggata tgttgaccaa agaagtgctt      420

ggtgaagtac gtacagaccg tcctgacggt ttatatacca ccctagttgt cgaccaatat      480

gagcgttgtc tagggttggt gtattcttcg aagaaatcta tagcaaaggc catcgatttg      540

ggtcgtggcg tttattattc tcgttctagg aatgaaatct ggatcaaggg tgaaacttct      600

ggcaatggcc aaaagctttt acaaatctct actgactgtg attcggatgc cttaaagttt      660

atcgttgaac aagaaaacgt tggattttgc cacttggaga ccatgtcttg ctttggtgaa      720

ttcaagcatg gtttggtggg gctagaatct ttactaaaac aaaggctaca ggacgctcca      780

gaggaatctt atactagaag actattcaac gactctgcat tgttagatgc caagatcaag      840

gaagaagctg aagaactgac tgaggcaaag ggtaagaagg agctttcttg ggaggctgcc      900

gatttgttct actttgcact ggccaaatta gtggccaacg atgtttcatt gaaggacgtc      960

gagaataatc tgaatatgaa gcatctgaag gttacaagac ggaaaggtga tgctaagcca     1020

aagtttgttg gacaaccaaa ggctgaagaa gaaaaactga ccggtccaat tcacttggac     1080

gtggtgaagg cttccgacaa agttggtgtg cagaaggctt tgagcagacc aatccaaaag     1140

acttctgaaa ttatgcattt agtcaatccg atcatcgaaa atgttagaga caaaggtaac     1200

tctgcccttt tggagtacac agaaaagttt gatggtgtaa aattatccaa tcctgttctt     1260

aatgctccat tcccagaaga atactttgaa ggtttaaccg aggaaatgaa ggaagctttg     1320

gacctttcaa ttgaaaacgt ccgcaaattc catgctgctc aattgccaac agagactctt     1380

gaagttgaaa cccaacctgg tgtcttgtgt tccagattcc ctcgtcctat tgaaaaagtt     1440

ggtttgtata tccctggtgg cactgccatt ttaccaagta ctgcattaat gcttggtgtt     1500

ccagcacaag ttgcccaatg taaggagatt gtgtttgcat ctccaccaag aaaatctgat     1560

ggtaaagttt cacccgaagt tgtttatgtc gcagaaaaag ttggcgcttc caagattgtt     1620

ctagctggtg gtgcccaagc cgttgctgct atggcttacg ggacagaaac tattcctaaa     1680

gtggataaga tcttgggtcc aggtaatcaa tttgtgactg ccgccaaaat gtatgttcaa     1740

aatgacactc aagctctatg ttccattgat atgccagctg gcccaagtga agttttggtt     1800

attgccgatg aagatgccga tgtggatttt gttgcaagtg atttgctatc gcaagctgaa     1860

cacggtattg actcccaagt tatccttgtt ggtgttaact tgagcgaaaa gaaaattcaa     1920

gagattcaag atgctgtcca caatcaagct ttacaactgc cacgtgtgga tattgttcgt     1980

aaatgtattg ctcacagtac gatcgttctt tgtgacggtt acgaagaagc ccttgaaatg     2040

tccaaccaat atgcaccaga acatttgatt ctacaaatcg ccaatgctaa cgattatgtt     2100

aaattggttg acaatgcagg gtccgtattt gtgggtgctt acactccaga atcgtgcggt     2160

gactattcaa gtggtactaa ccatacatta ccaacctatg gttacgctag gcagtacagt     2220

ggtgccaaca ctgcaacctt ccaaaagttt atcactgccc aaaacattac ccctgaaggt     2280

ttagaaaaca tcggtagagc tgttatgtgc gttgccaaga aggagggtct agacggtcac     2340

agaaacgctg tgaaaatcag aatgagtaag cttgggttga tcccaaagga tttccag        2397


<210>  30
<211>  843
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  30
atgttgaaaa tcgctgtccc aaacaagggc tcgctgtccg agcgcgccat ggaaatcctc       60

gccgaagcag gctacgcagg ccgtggagat tccaaatccc tcaacgtttt tgatgaagca      120

aacaacgttg aattcttctt ccttcgccct aaagatatcg ccatctacgt tgcaggtggc      180

cagctcgatt tgggtatcac cggccgcgac cttgctcgcg attcccaggc tgatgtccac      240

gaagttcttt ccctcggctt cggttcctcc accttccgtt acgcagcacc agctgatgaa      300

gagtggagca tcgaaaagct cgacggcaag cgcatcgcta cctcttaccc caaccttgtt      360

cgcgatgacc tcgcagcacg tgggctttcc gctgaggtgc tccgcctcga cggtgcagta      420

gaggtatcca tcaagcttgg tgtcgcagat gccatcgccg atgttgtatc caccggccgc      480

acgctgcgtc agcaaggtct tgcacctttc ggcgaggttc tgtgcacctc tgaggctgtc      540

attgttggcc gcaaggatga aaaggtcacc ccagagcagc agatcctgct tcgccgcatc      600

cagggaattt tgcacgcgca gaacttcctc atgctggatt acaacgtcga ccgcgacaac      660

ctggacgctg ccactgcagt aaccccaggc ctatccggcc caacggtatc cccactggca      720

cgcgacaact gggttgctgt acgcgccatg gtgccacgca ggtcagctaa cgccatcatg      780

gataagcttg ctggactcgg cgctgaagcc atcctggctt ctgaaatccg catcgcccgc      840

atc                                                                    843


<210>  31
<211>  261
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  31

Met Thr Lys Phe Ile Gly Cys Ile Asp Leu His Asn Gly Glu Val Lys 
1               5                   10                  15      


Gln Ile Val Gly Gly Thr Leu Thr Ser Lys Lys Glu Asp Val Pro Lys 
            20                  25                  30          


Thr Asn Phe Val Ser Gln His Pro Ser Ser Tyr Tyr Ala Lys Leu Tyr 
        35                  40                  45              


Lys Asp Arg Asp Val Gln Gly Cys His Val Ile Lys Leu Gly Pro Asn 
    50                  55                  60                  


Asn Asp Asp Ala Ala Arg Glu Ala Leu Gln Glu Ser Pro Gln Phe Leu 
65                  70                  75                  80  


Gln Val Gly Gly Gly Ile Asn Asp Thr Asn Cys Leu Glu Trp Leu Lys 
                85                  90                  95      


Trp Ala Ser Lys Val Ile Val Thr Ser Trp Leu Phe Thr Lys Glu Gly 
            100                 105                 110         


His Phe Gln Leu Lys Arg Leu Glu Arg Leu Thr Glu Leu Cys Gly Lys 
        115                 120                 125             


Asp Arg Ile Val Val Asp Leu Ser Cys Arg Lys Thr Gln Asp Gly Arg 
    130                 135                 140                 


Trp Ile Val Ala Met Asn Lys Trp Gln Thr Leu Thr Asp Leu Glu Leu 
145                 150                 155                 160 


Asn Ala Asp Thr Phe Arg Glu Leu Arg Lys Tyr Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile His Ala Ala Asp Val Glu Gly Leu Cys Gly Gly Ile Asp Glu Leu 
            180                 185                 190         


Leu Val Ser Lys Leu Phe Glu Trp Thr Lys Asp Tyr Asp Asp Leu Lys 
        195                 200                 205             


Ile Val Tyr Ala Gly Gly Ala Lys Ser Val Asp Asp Leu Lys Leu Val 
    210                 215                 220                 


Asp Glu Leu Ser His Gly Lys Val Asp Leu Thr Phe Gly Ser Ser Leu 
225                 230                 235                 240 


Asp Ile Phe Gly Gly Asn Leu Val Lys Phe Glu Asp Cys Cys Arg Trp 
                245                 250                 255     


Asn Glu Lys Gln Gly 
            260     


<210>  32
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  32

Met Ala Arg Thr Phe Phe Val Gly Gly Asn Phe Lys Leu Asn Gly Ser 
1               5                   10                  15      


Lys Gln Ser Ile Lys Glu Ile Val Glu Arg Leu Asn Thr Ala Ser Ile 
            20                  25                  30          


Pro Glu Asn Val Glu Val Val Ile Cys Pro Pro Ala Thr Tyr Leu Asp 
        35                  40                  45              


Tyr Ser Val Ser Leu Val Lys Lys Pro Gln Val Thr Val Gly Ala Gln 
    50                  55                  60                  


Asn Ala Tyr Leu Lys Ala Ser Gly Ala Phe Thr Gly Glu Asn Ser Val 
65                  70                  75                  80  


Asp Gln Ile Lys Asp Val Gly Ala Lys Trp Val Ile Leu Gly His Ser 
                85                  90                  95      


Glu Arg Arg Ser Tyr Phe His Glu Asp Asp Lys Phe Ile Ala Asp Lys 
            100                 105                 110         


Thr Lys Phe Ala Leu Gly Gln Gly Val Gly Val Ile Leu Cys Ile Gly 
        115                 120                 125             


Glu Thr Leu Glu Glu Lys Lys Ala Gly Lys Thr Leu Asp Val Val Glu 
    130                 135                 140                 


Arg Gln Leu Asn Ala Val Leu Glu Glu Val Lys Asp Trp Thr Asn Val 
145                 150                 155                 160 


Val Val Ala Tyr Glu Pro Val Trp Ala Val Gly Thr Gly Leu Ala Ala 
                165                 170                 175     


Thr Pro Glu Asp Ala Gln Asp Ile His Ala Ser Ile Arg Lys Phe Leu 
            180                 185                 190         


Ala Ser Lys Leu Gly Asp Lys Ala Ala Ser Glu Leu Arg Ile Leu Tyr 
        195                 200                 205             


Gly Gly Ser Ala Asn Gly Ser Asn Ala Val Thr Phe Lys Asp Lys Ala 
    210                 215                 220                 


Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu Phe 
225                 230                 235                 240 


Val Asp Ile Ile Asn Ser Arg Asn 
                245             


<210>  33
<211>  408
<212>  PRT
<213>  Pseudomonas rhizosphaerae

<400>  33

Met Thr Leu Ser Thr Ala Asp Thr His Arg Leu Asp Asp Phe Trp Gln 
1               5                   10                  15      


His Cys Leu Lys His Gln Phe Phe Asn Ile Gly Tyr Pro Glu Asn Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ser Ala Leu Glu Arg Phe Leu Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Ser Glu His Ser Asn Tyr Val Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Lys Glu Val Met Ala Tyr Phe Ala Asp Leu Phe Glu Ile 
65                  70                  75                  80  


Pro Arg Glu Asp Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Asp Gly Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Val Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Cys Arg Ala Val Asn Ala Leu Pro Thr Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Leu Ala Lys Ile Ala Ala Asp Gly Glu Arg 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Met Arg Gly Ala Val 
                165                 170                 175     


Asp Asp Ile Ala Val Ile Gln Gln Arg Leu Gln Asp Ala Gly Ile Ala 
            180                 185                 190         


Arg Arg Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Ala Pro Gln Pro Phe Thr Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Cys Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Lys Arg Arg Asn Val Ala Arg Ile Ser Val 
                245                 250                 255     


Glu Val Asp Tyr Ile Ser Ala Ser Asp Lys Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Met Ile Met Trp Ala Ala Leu Arg Ser His Ser 
        275                 280                 285             


Ser Ala Gln Trp Arg Arg Arg Val Glu Arg Ser Leu Ala Ala Ala Gln 
    290                 295                 300                 


Tyr Ala Val Asn Arg Leu Gln Ala Gly Gly Val Lys Ala Trp Arg Asn 
305                 310                 315                 320 


Pro Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Ala Asp Ile Ala 
                325                 330                 335     


Arg Lys Tyr Gly Leu Ala Thr Ser Gly Asp Thr Ala His Leu Ile Thr 
            340                 345                 350         


Thr Pro His His Arg Asp Asn Arg Ala Ile Asp Ala Leu Ile Asp Glu 
        355                 360                 365             


Val Ile Ala Asp Ala Arg Pro Glu Val Trp Arg Ala Thr Leu Gln Arg 
    370                 375                 380                 


Ser Trp Gln Gly Ser Ala Gln Arg Leu Pro Arg Thr Ala Ser Trp Asn 
385                 390                 395                 400 


Gln Ala Ala Gly Leu Gly Arg Phe 
                405             


<210>  34
<211>  427
<212>  PRT
<213>  Pseudomonas putida (Arthrobacter siderocapsulatus)

<400>  34

Met Thr Phe Ser Pro Ala Asp His Lys Arg Leu Glu Ala Phe Trp Gln 
1               5                   10                  15      


Tyr Cys Leu Thr His Gln Tyr Phe Asn Val Gly Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ser Leu Leu His Arg Phe Met Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Asn Glu Pro Ser Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Arg Glu Val Met Arg Phe Phe Ala Glu Leu Phe His Ile 
65                  70                  75                  80  


Pro Phe Glu Asp Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Asp Ala Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Val Arg 
        115                 120                 125             


Leu Leu Arg Ile Lys Ala Gln Val Val Glu Ser Gln Ala Asn Gly Glu 
    130                 135                 140                 


Met Asp Tyr Asp Asp Leu Val Ala Arg Ile Ala Ala Asp Gly Glu Arg 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Leu Arg Gly Ala Thr 
                165                 170                 175     


Asp Asn Ile Ala Val Ile Gln Gln Arg Leu Ala Gln Ala Gly Ile Arg 
            180                 185                 190         


Arg Glu Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Ala Pro Glu Pro Tyr Ser Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Cys Val Ser Gly His Lys Met Ile Gly Ser Pro Met Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Arg Arg His Asn Val Glu Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala Arg Asp Gln Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Leu Met Met Trp Ala Ala Leu Cys Ser Arg Ser 
        275                 280                 285             


Arg Glu Asp Trp Arg Ala Arg Ile Gln Arg Cys Leu Asp Leu Ala Gln 
    290                 295                 300                 


His Ala Val Asp Arg Leu Arg Ala Ala Gly Ile Glu Ala Trp Arg Asn 
305                 310                 315                 320 


Pro Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Ala Ser Val Trp 
                325                 330                 335     


Lys Arg His Cys Leu Ala Thr Ser Gly Asp Thr Ala His Leu Ile Thr 
            340                 345                 350         


Thr Ala His His Gln Asp Ser Thr Gln Ile Asp Ala Leu Leu Asp Glu 
        355                 360                 365             


Leu Ile Ala Asp Leu Lys Ala Arg Thr Arg Tyr Pro Leu Gln Ala Pro 
    370                 375                 380                 


Leu Val Glu Gly Leu Gly Ser Arg Thr Arg Val Tyr Ser Thr Ala Gly 
385                 390                 395                 400 


Gln Pro Arg Pro Glu Pro Leu Pro Asp His Ala Arg Pro Ala Arg Asp 
                405                 410                 415     


Ser Gly Leu Ala Arg Leu Lys Asp Ser Glu Ile 
            420                 425         


<210>  35
<211>  378
<212>  PRT
<213>  Citrobacter pasteurii

<400>  35

Met Thr Leu Ser Ile Val Asp Gln Asn Lys Leu Asp Ala Phe Trp Ser 
1               5                   10                  15      


Tyr Cys Val Lys Asn Gln Tyr Phe Asn Ile Gly Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Thr Ile Leu Glu Arg Phe Met Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Gly Glu Tyr Cys Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Lys Glu Val Met Glu Tyr Phe Ala Arg Ile Phe Lys Ile 
65                  70                  75                  80  


Pro Phe Glu Glu Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Gly Arg Glu Leu Phe Pro Glu Gly Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Val Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Ser Ser Leu Val Glu Ser Gln Pro Asn Gly Glu 
    130                 135                 140                 


Met Asp Tyr Asp Asp Leu Ile Arg Lys Ile Gln Arg Asp Asn Glu Glu 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Val Arg Gly Ala Ile 
                165                 170                 175     


Asp Asn Ile Ala Glu Ile Gln Gln Arg Ile Gly Gln Leu Gly Ile Lys 
            180                 185                 190         


Arg Asp Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asn Asp Pro Gln Pro Phe Asn Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Gly Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Lys Arg Lys Asn Val Asp Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala His Asp Lys Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Leu Met Met Trp Glu Ala Ile Arg Ser His Ser 
        275                 280                 285             


Trp Ser Asp Trp Gln Arg Arg Ile Glu His Ser Leu Asn Met Ala Gln 
    290                 295                 300                 


Tyr Ala Val Asp Arg Leu Gln Ala Ala Gly Ile Asp Ala Trp Arg Asn 
305                 310                 315                 320 


Lys Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Glu Ala Val Trp 
                325                 330                 335     


Lys Lys His Cys Leu Ala Thr Ser Gly Asp Ile Ala His Leu Ile Thr 
            340                 345                 350         


Thr Ala His His Leu Asp Ser Ser Lys Ile Asp Glu Leu Ile Asp Asp 
        355                 360                 365             


Val Ile Ala Asp Leu Asn Gln Gln Ala Ala 
    370                 375             


<210>  36
<211>  387
<212>  PRT
<213>  Chromobacterium haemolyticum

<400>  36

Met Ser Leu Ser Ser Leu Asp Gln Asn Arg Ile Glu Ser Phe Trp Gln 
1               5                   10                  15      


Tyr Cys Leu Gln His Gln Tyr Phe Asn Leu Ala Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Thr Pro Leu His Arg Phe Leu Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Asn Glu Ser Ser Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Arg Glu Val Met His Phe Phe Ala Glu Leu Phe His Ile 
65                  70                  75                  80  


Pro Phe Asp Glu Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Asp Ala Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Ser His Tyr Ser Val Ala Lys Ile Ile Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Ser Arg Ala Val Asp Ser Leu Pro Ser Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Val Ala Lys Ile Gln Gln Asp Gln Glu Arg 
145                 150                 155                 160 


His Pro Ile Val Phe Val Asn Val Gly Thr Thr Met Lys Gly Ala Val 
                165                 170                 175     


Asp Asp Ile Gly Ile Ile Gln Asp Lys Leu Ala Gln Ala Gly Ile Pro 
            180                 185                 190         


Arg Arg Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Ala Pro Gln Pro Tyr Ser Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Ser Val Ser Gly His Lys Met Ile Gly Ser Pro Met Pro 
225                 230                 235                 240 


Cys Gly Ile Val Leu Ala Lys Arg Ser Asn Val Ser Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala Arg Asp Gln Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Met Met Leu Trp Ala Ala Ile Lys Ser Arg Pro 
        275                 280                 285             


Leu Ala Glu Trp Arg Arg Lys Val Arg His Cys Leu Asp Met Ala Gln 
    290                 295                 300                 


Tyr Ala Ile Asp Arg Phe Arg Ala Ala Gly Ile Gln Ala Trp Arg Cys 
305                 310                 315                 320 


Gln Asn Ser Ile Thr Val Val Phe Pro Ser Pro Ser Glu Pro Val Cys 
                325                 330                 335     


Asp Lys His Gly Leu Ala Arg Ser Gly Gly Ala Ala His Leu Ile Thr 
            340                 345                 350         


Thr Pro His His His Asp Ser Gln Arg Leu Asp Arg Leu Ile Asp Asp 
        355                 360                 365             


Ile Ile Gln Asp Leu Gly Ala Val Thr Ala Pro Ala Gly Ala Ala Met 
    370                 375                 380                 


Ser Ala Ala 
385         


<210>  37
<211>  311
<212>  PRT
<213>  Lactobacillus reuteri

<400>  37

Met Ser Glu Leu Asp Thr Lys Leu His Lys Leu Gly Val Asp Arg Ile 
1               5                   10                  15      


Ala Ile Ser Pro Tyr Lys Gln Trp Ser Arg Gly Tyr Met Glu Pro Gly 
            20                  25                  30          


Asn Ile Gly Asn Gly Tyr Val Thr Gly Leu Lys Val Asp Ala Gly Val 
        35                  40                  45              


Arg Asp Lys Thr Asp Asp Glu Val Leu Asp Gly Ile Val Ser Tyr Asp 
    50                  55                  60                  


Arg Ala Glu Thr Lys Asn Ala Tyr Ile Gly Gln Ile Asn Met Thr Thr 
65                  70                  75                  80  


Ala Ser Ser Phe Thr Gly Pro Gln Gly His Cys Ile Gly Tyr Asp Leu 
                85                  90                  95      


Leu Arg Asn Pro Glu Val Asp Thr Ala Glu Pro Leu Phe Thr Val Lys 
            100                 105                 110         


Gln Trp Asp Gly Ser Glu Leu Pro Ile Tyr Asp Ala Lys Pro Leu Gln 
        115                 120                 125             


Asp Ser Leu Val Glu Tyr Phe Gly Thr Asn Asn Asn Arg Arg His Tyr 
    130                 135                 140                 


Pro Ala Pro Gly Ser Phe Ile Val Cys Ala Asn Lys Gly Val Thr Ala 
145                 150                 155                 160 


Glu Arg Pro Met Asn Asp Ser Asp Met Lys Pro Gly Gln Gly Tyr Gly 
                165                 170                 175     


Val Trp Ser Ala Ile Ala Leu Ser Phe Ala Lys Asp Pro Ala Lys Asp 
            180                 185                 190         


Ser Ser Met Phe Ile Glu Asp Ala Gly Val Trp Glu Thr Pro Asn Glu 
        195                 200                 205             


Asp Glu Leu Ile Glu Tyr Leu Lys Gly Arg Arg Lys Ala Ile Ala Lys 
    210                 215                 220                 


Ser Ile Ala Glu Cys Gly Gln Asp Ala Asn Thr Ser Phe Lys Gly Ser 
225                 230                 235                 240 


Trp Ile Gly Phe Ala His Ala Met Met Glu Pro Gly Gln Ile Gly Asn 
                245                 250                 255     


Ala Ile Thr Val Ala Pro Tyr Ile Ser Met Pro Val Asp Ser Ile Pro 
            260                 265                 270         


Gly Gly Ser Ile Leu Thr Pro Asp Thr Asp Met Asp Ile Met Glu Asn 
        275                 280                 285             


Leu Thr Met Pro Glu Trp Leu Asp Lys Met Glu Tyr Lys Ser Leu Thr 
    290                 295                 300                 


Ala Asn Gly Ala Ile Lys Tyr 
305                 310     


<210>  38
<211>  390
<212>  PRT
<213>  Aeromonas salmonicida subsp. pectinolytica 34mel

<400>  38

Met Cys Arg His Ala Cys Ile Ala Leu Ala Met Gly Met Ile Met Gly 
1               5                   10                  15      


Leu Ser Ser Glu Asp Ala Gly Lys Ile Glu Ser Phe Trp Arg Tyr Cys 
            20                  25                  30          


Val Gln His Gln Tyr Phe Asn Ile Gly Tyr Pro Glu Ala Ala Asp Phe 
        35                  40                  45              


Asp Tyr Ser Ala Leu Asn Arg Phe Leu Asn Phe Ser Ile Asn Asn Cys 
    50                  55                  60                  


Gly Asp Trp Ser Gln Gln Ser Asn Tyr Leu Leu Asn Ser Phe Asp Phe 
65                  70                  75                  80  


Glu Arg Glu Val Met Gln Phe Phe Ala Thr Leu Phe Cys Ile Pro Phe 
                85                  90                  95      


Glu Gln Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly Asn Met 
            100                 105                 110         


Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Glu Ala Thr Leu Tyr 
        115                 120                 125             


Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Ile Arg Leu Leu 
    130                 135                 140                 


Arg Val Lys Ser Cys Met Val Asp Ser Leu Pro Asn Gly Glu Met Asn 
145                 150                 155                 160 


Tyr Asp Asp Leu Ile Asn Arg Ile Arg Leu Asp Gly Glu Arg His Pro 
                165                 170                 175     


Ile Ile Phe Ala Asn Ile Gly Thr Thr Met Thr Gly Ala Thr Asp Asn 
            180                 185                 190         


Ile Ala Thr Ile Gln Arg Arg Leu Lys Lys Ile Gly Ile Thr Lys Gly 
        195                 200                 205             


Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile Leu Pro 
    210                 215                 220                 


Phe Ile Asp Asn Pro Gln Pro Phe Ser Phe Ala Asp Gly Val Asp Ser 
225                 230                 235                 240 


Ile Ser Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro Cys Gly 
                245                 250                 255     


Ile Val Leu Ala Arg Arg Lys His Val Glu His Val Ser Val Glu Ile 
            260                 265                 270         


Asp Tyr Ile Ser Ala Cys Asp Gln Thr Ile Ser Gly Ser Arg Asn Gly 
        275                 280                 285             


Tyr Thr Pro Leu Leu Leu Trp Met Ala Ile Lys Ser Arg Ser Phe Ser 
    290                 295                 300                 


Asp Trp Arg Gln Arg Thr Gln His Cys Leu Asp Met Ala Gln Tyr Val 
305                 310                 315                 320 


Ile Glu Arg Phe His Ala Lys Gly Ile His Ala Trp Arg Asn Pro Asn 
                325                 330                 335     


Ser Ile Thr Val Val Phe Pro Lys Pro Ala Asp His Ile Trp Lys Lys 
            340                 345                 350         


His Cys Leu Ala Thr Ser Gly Lys Ile Ser His Ile Ile Thr Met Pro 
        355                 360                 365             


His His Thr Gly Lys Glu Thr Leu Asp Arg Val Ile Asn Asp Ile Ala 
    370                 375                 380                 


Leu Asp Arg Glu Pro Lys 
385                 390 


<210>  39
<211>  378
<212>  PRT
<213>  Morganella psychrotolerans

<400>  39

Met Thr Leu Ser Ile Asn Asp Gln Asn Lys Leu Asp Ala Phe Trp Ala 
1               5                   10                  15      


Tyr Cys Val Lys Asn Gln Tyr Phe Asn Ile Gly Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Thr Asn Leu Glu Arg Phe Leu Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Gly Glu Tyr Cys Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Lys Glu Val Met Glu Tyr Phe Ala Asp Leu Phe Lys Ile 
65                  70                  75                  80  


Pro Phe Glu Lys Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Gly Arg Glu Ile Phe Pro Asp Gly Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Val Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Ser Gln Val Val Glu Ala Gln Pro Asn Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Met Lys Lys Ile Ala Ala Asp Lys Glu Ala 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Val Arg Gly Ala Ile 
                165                 170                 175     


Asp Asp Ile Thr Glu Ile Gln Lys Arg Met Lys Ala Ala Gly Ile Lys 
            180                 185                 190         


Arg Glu Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Glu Pro Gln Ala Phe Thr Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Gly Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Lys Lys Glu Asn Val Asp Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala His Asp Lys Thr Ile Thr Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Leu Met Leu Trp Glu Ala Val Arg Ala His Ser 
        275                 280                 285             


Thr Glu Asp Trp Lys Arg Arg Ile Gly Arg Ser Leu Asp Met Ala Gln 
    290                 295                 300                 


Tyr Ala Val Asp Arg Leu Gln Lys Ala Gly Ile Asn Ala Trp Arg Asn 
305                 310                 315                 320 


Lys Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Glu Arg Val Trp 
                325                 330                 335     


Lys Glu His Cys Leu Ala Thr Ser Gly Asn Asp Ala His Leu Ile Thr 
            340                 345                 350         


Thr Ala His His Leu Asp Thr Ala Gln Ile Asp Ala Leu Ile Asp Asp 
        355                 360                 365             


Val Ile Ala Asp Ala Lys Leu His Ala Ala 
    370                 375             


<210>  40
<211>  311
<212>  PRT
<213>  Lactobacillus fructivorans

<400>  40

Met Ala Lys Ile Asp Lys Ile Leu Asn Gln Glu Gly Ile Asp Arg Ile 
1               5                   10                  15      


Ala Ile Asn Pro Tyr Gln Lys Tyr Ser Arg Gly Tyr Met Glu Pro Gly 
            20                  25                  30          


Asn Leu Gly Gly Gly Tyr Val Thr Gly Leu Lys Val Asp Ala Gly Thr 
        35                  40                  45              


Arg Glu Lys Thr Asp Asp Ser Met Leu Asp Gly Ile Val Ser Tyr Asp 
    50                  55                  60                  


Arg Ala Glu Cys Lys Asn Ala Tyr Ile Gly Gln Ile Asn Met Met Thr 
65                  70                  75                  80  


Ala Ser Ser Phe Thr Gly Val Gln Gly His Ile Leu Gly Tyr Asp Leu 
                85                  90                  95      


Leu Arg Asn Pro Ala Val Asp Lys Ala Gln Pro Leu Phe Tyr Glu Thr 
            100                 105                 110         


Gln Trp Asp Gly Ser Lys Leu Pro Ile Tyr Asp Gly Lys Pro Leu Gln 
        115                 120                 125             


Asp Ser Leu Val Glu Phe Phe Gly Thr Ala Asp Asn Arg Arg His Tyr 
    130                 135                 140                 


Pro Ala Pro Gly Ser Phe Ile Val Cys Ala Asn Lys Gly Val Thr Ala 
145                 150                 155                 160 


Glu Arg Pro Leu Glu Asp Arg Pro Leu Asn Pro Gly Glu Ala Tyr Gly 
                165                 170                 175     


Val Trp Ser Ala Ile Ala Ile Ser Ile Ala Lys Asp Pro Val His Asn 
            180                 185                 190         


Ser Ser Met Phe Ile Glu Asp Ala Gly Thr Trp Asn Thr Pro Asn Glu 
        195                 200                 205             


Asp Asp Leu Asn Glu Phe Leu Tyr His Arg Arg Glu Ala Ile Ala Arg 
    210                 215                 220                 


Ser Ile Ala Gln Cys Gly Gln Asp Ala Ser Thr Ser Phe Ala Ser Ser 
225                 230                 235                 240 


Trp Ile Gly Phe Ala His Val Met Met Lys Pro Gly Glu Ile Gly Asn 
                245                 250                 255     


Ala Ile Thr Val Gly Pro Tyr Phe Ser Met Pro Val Asp Ala Val Pro 
            260                 265                 270         


Gly Gly Ser Ile Leu Thr Pro Asp Val Asp Met Asn Ile Met Glu Asp 
        275                 280                 285             


Leu Ser Leu Pro Glu Trp Leu Glu Lys Met Gly Tyr Gln Ser Ile Val 
    290                 295                 300                 


Glu Asn Gln Asp Ile Gln Tyr 
305                 310     


<210>  41
<211>  315
<212>  PRT
<213>  Escherichia coli (strain K12)

<400>  41

Met Pro Asp Met Lys Leu Phe Ala Gly Asn Ala Thr Pro Glu Leu Ala 
1               5                   10                  15      


Gln Arg Ile Ala Asn Arg Leu Tyr Thr Ser Leu Gly Asp Ala Ala Val 
            20                  25                  30          


Gly Arg Phe Ser Asp Gly Glu Val Ser Val Gln Ile Asn Glu Asn Val 
        35                  40                  45              


Arg Gly Gly Asp Ile Phe Ile Ile Gln Ser Thr Cys Ala Pro Thr Asn 
    50                  55                  60                  


Asp Asn Leu Met Glu Leu Val Val Met Val Asp Ala Leu Arg Arg Ala 
65                  70                  75                  80  


Ser Ala Gly Arg Ile Thr Ala Val Ile Pro Tyr Phe Gly Tyr Ala Arg 
                85                  90                  95      


Gln Asp Arg Arg Val Arg Ser Ala Arg Val Pro Ile Thr Ala Lys Val 
            100                 105                 110         


Val Ala Asp Phe Leu Ser Ser Val Gly Val Asp Arg Val Leu Thr Val 
        115                 120                 125             


Asp Leu His Ala Glu Gln Ile Gln Gly Phe Phe Asp Val Pro Val Asp 
    130                 135                 140                 


Asn Val Phe Gly Ser Pro Ile Leu Leu Glu Asp Met Leu Gln Leu Asn 
145                 150                 155                 160 


Leu Asp Asn Pro Ile Val Val Ser Pro Asp Ile Gly Gly Val Val Arg 
                165                 170                 175     


Ala Arg Ala Ile Ala Lys Leu Leu Asn Asp Thr Asp Met Ala Ile Ile 
            180                 185                 190         


Asp Lys Arg Arg Pro Arg Ala Asn Val Ser Gln Val Met His Ile Ile 
        195                 200                 205             


Gly Asp Val Ala Gly Arg Asp Cys Val Leu Val Asp Asp Met Ile Asp 
    210                 215                 220                 


Thr Gly Gly Thr Leu Cys Lys Ala Ala Glu Ala Leu Lys Glu Arg Gly 
225                 230                 235                 240 


Ala Lys Arg Val Phe Ala Tyr Ala Thr His Pro Ile Phe Ser Gly Asn 
                245                 250                 255     


Ala Ala Asn Asn Leu Arg Asn Ser Val Ile Asp Glu Val Val Val Cys 
            260                 265                 270         


Asp Thr Ile Pro Leu Ser Asp Glu Ile Lys Ser Leu Pro Asn Val Arg 
        275                 280                 285             


Thr Leu Thr Leu Ser Gly Met Leu Ala Glu Ala Ile Arg Arg Ile Ser 
    290                 295                 300                 


Asn Glu Glu Ser Ile Ser Ala Met Phe Glu His 
305                 310                 315 


<210>  42
<211>  337
<212>  PRT
<213>  Arabidopsis thaliana (Mouse-ear cress)

<400>  42

Met Ser Glu Asn Ala Ala Asn Asn Ile Met Glu Thr Lys Ile Cys Thr 
1               5                   10                  15      


Asp Ala Ile Val Ser Glu Leu Gln Lys Lys Lys Val His Leu Phe Tyr 
            20                  25                  30          


Cys Leu Glu Cys Glu Glu Leu Ala Arg Asn Ile Ala Ala Glu Ser Asp 
        35                  40                  45              


His Ile Thr Leu Gln Ser Ile Asn Trp Arg Ser Phe Ala Asp Gly Phe 
    50                  55                  60                  


Pro Asn Leu Phe Ile Asn Asn Ala His Asp Ile Arg Gly Gln His Val 
65                  70                  75                  80  


Ala Phe Leu Ala Ser Phe Ser Ser Pro Ala Val Ile Phe Glu Gln Ile 
                85                  90                  95      


Ser Val Ile Tyr Leu Leu Pro Arg Leu Phe Val Ala Ser Phe Thr Leu 
            100                 105                 110         


Val Leu Pro Phe Phe Pro Thr Gly Ser Phe Glu Arg Met Glu Glu Glu 
        115                 120                 125             


Gly Asp Val Ala Thr Ala Phe Thr Met Ala Arg Ile Val Ser Asn Ile 
    130                 135                 140                 


Pro Ile Ser Arg Gly Gly Pro Thr Ser Val Val Ile Tyr Asp Ile His 
145                 150                 155                 160 


Ala Leu Gln Glu Arg Phe Tyr Phe Ala Asp Gln Val Leu Pro Leu Phe 
                165                 170                 175     


Glu Thr Gly Ile Pro Leu Leu Thr Lys Arg Leu Gln Gln Leu Pro Glu 
            180                 185                 190         


Thr Glu Lys Val Ile Val Ala Phe Pro Asp Asp Gly Ala Trp Lys Arg 
        195                 200                 205             


Phe His Lys Leu Leu Asp His Tyr Pro Thr Val Val Cys Thr Lys Val 
    210                 215                 220                 


Arg Glu Gly Asp Lys Arg Ile Val Arg Leu Lys Glu Gly Asn Pro Ala 
225                 230                 235                 240 


Gly Cys His Val Val Ile Val Asp Asp Leu Val Gln Ser Gly Gly Thr 
                245                 250                 255     


Leu Ile Glu Cys Gln Lys Val Leu Ala Ala His Gly Ala Val Lys Val 
            260                 265                 270         


Ser Ala Tyr Val Thr His Gly Val Phe Pro Lys Ser Ser Trp Glu Arg 
        275                 280                 285             


Phe Thr His Lys Lys Asn Gly Leu Glu Glu Ala Phe Ala Tyr Phe Trp 
    290                 295                 300                 


Ile Thr Asp Ser Cys Pro Gln Thr Val Lys Ala Ile Gly Asn Lys Ala 
305                 310                 315                 320 


Pro Phe Glu Val Leu Ser Leu Ala Gly Ser Ile Ala Asp Ala Leu Gln 
                325                 330                 335     


Ile 
    


<210>  43
<211>  318
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  43

Met Ser Thr Asn Ser Ile Lys Leu Leu Ala Gly Asn Ser His Pro Gly 
1               5                   10                  15      


Leu Ala Glu Leu Ile Ser Gln Arg Leu Gly Val Pro Leu Ser Lys Val 
            20                  25                  30          


Gly Val Tyr Gln Tyr Ser Asn Lys Glu Thr Ser Val Thr Ile Gly Glu 
        35                  40                  45              


Ser Ile Arg Asp Glu Asp Val Tyr Ile Ile Gln Thr Gly Tyr Gly Glu 
    50                  55                  60                  


His Glu Ile Asn Asp Phe Leu Met Glu Leu Leu Ile Leu Ile His Ala 
65                  70                  75                  80  


Cys Lys Thr Ala Ser Val Arg Arg Ile Thr Ala Val Ile Pro Asn Phe 
                85                  90                  95      


Pro Tyr Ala Arg Gln Asp Lys Lys Asp Lys Ser Arg Ala Pro Ile Thr 
            100                 105                 110         


Ala Lys Leu Ile Ala Asn Leu Leu Glu Thr Ala Gly Cys Asp His Val 
        115                 120                 125             


Ile Thr Met Asp Leu His Ala Ser Gln Ile Gln Gly Phe Phe His Ile 
    130                 135                 140                 


Pro Val Asp Asn Leu Tyr Gly Glu Pro Ser Val Leu Asn Tyr Ile Arg 
145                 150                 155                 160 


Thr Lys Thr Asp Phe Asn Asn Ala Ile Leu Val Ser Pro Asp Ala Gly 
                165                 170                 175     


Gly Ala Lys Arg Val Ala Ser Leu Ala Asp Lys Leu Asp Met Asn Phe 
            180                 185                 190         


Ala Leu Ile His Lys Glu Arg Gln Lys Ala Asn Glu Val Ser Arg Met 
        195                 200                 205             


Leu Leu Val Gly Asp Val Ala Gly Lys Ser Cys Leu Leu Ile Asp Asp 
    210                 215                 220                 


Met Ala Asp Thr Cys Gly Thr Leu Val Lys Ala Cys Asp Thr Leu Met 
225                 230                 235                 240 


Asp His Gly Ala Lys Glu Val Ile Ala Ile Val Thr His Gly Ile Phe 
                245                 250                 255     


Ser Gly Ser Ala Arg Glu Lys Leu Ile Asn Ser Arg Leu Ser Arg Ile 
            260                 265                 270         


Val Cys Thr Asn Thr Val Pro Val Asp Leu Asp Leu Asp Ile Val Asp 
        275                 280                 285             


Gln Val Asp Ile Ser Pro Thr Ile Ala Glu Ala Ile Arg Arg Leu His 
    290                 295                 300                 


Asn Gly Glu Ser Val Ser Tyr Leu Phe Thr His Ala Pro Val 
305                 310                 315             


<210>  44
<211>  427
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  44

Met Arg Lys Cys Lys Ile Phe Val Gly Asn Ser His Pro Glu Leu Gly 
1               5                   10                  15      


Asn Met Val Cys Gln Arg Leu Gly Ile Glu Pro Ala Pro Cys Thr Leu 
            20                  25                  30          


Lys Lys Phe Ala Asn Gly Glu Thr Ser Val Gln Ile Gly Val Ser Val 
        35                  40                  45              


Arg Asp Glu Asp Val Tyr Val Ile Gln Ser Gly Ser Pro Ser Ile Asn 
    50                  55                  60                  


Asp Asp Ile Met Glu Leu Leu Ile Leu Val Ser Ala Cys Arg Gly Gly 
65                  70                  75                  80  


Ser Ala Arg Lys Ile Thr Ala Val Ile Pro Gln Phe Pro Tyr Ser Lys 
                85                  90                  95      


Gln Cys Lys Met Lys Arg His Arg Gly Ala Ile Thr Ala Arg Met Leu 
            100                 105                 110         


Ala Asn Leu Leu Val Met Ala Gly Ala Asp His Val Val Ser Met Asp 
        115                 120                 125             


Leu His Ala Ser Gln Met Gln Gly Phe Phe Thr Lys Pro Val Asp Asn 
    130                 135                 140                 


Leu Tyr Gly Gly Pro Ser Leu Ala Lys Trp Ile Arg Glu Asn Val Glu 
145                 150                 155                 160 


Asp Tyr Glu Asp Ala Val Val Val Ser Lys Asn Pro Gly Gly Thr Lys 
                165                 170                 175     


Arg Val Thr Ala Leu Ala Asp Ser Leu Lys Ile Asn Phe Ala Met Ile 
            180                 185                 190         


His Thr Asp Arg Arg Arg Ser Lys Asp Leu Tyr Ser Gln Asn Lys Asp 
        195                 200                 205             


Leu Gln Gln Leu Lys Leu Arg Lys Gln Ser Met Leu Arg Lys Asn Arg 
    210                 215                 220                 


Pro Ile Ile Arg Gln Gly Asp His Pro Asn Glu Glu Glu Asn Ile Ile 
225                 230                 235                 240 


Leu Ser Asn Gly Ile Gln Thr Ala Arg Ile Arg Asn Gly His Val Ile 
                245                 250                 255     


Gly Asp Asp Glu Ala Asp Asp Asp Glu Asp Ala Ile Leu Glu Ser Asp 
            260                 265                 270         


Ser Glu Leu His Ser Ile Asp Gly Leu Asp Ser His Gly Leu Gly Gly 
        275                 280                 285             


Thr Tyr Asp Ala Val Asp Ser Glu Asp Glu Glu Glu Ile Pro Val Leu 
    290                 295                 300                 


Tyr Arg Glu Gln Leu Ile Thr Leu Val Gly Asn Val Arg Gly Arg Ser 
305                 310                 315                 320 


Ala Ile Ile Leu Asp Asp Met Ile Asp Arg Pro Gly Ser Phe Ile Ser 
                325                 330                 335     


Ala Ala Glu His Leu Val Gln Asn Cys Gly Ala Lys Lys Val Tyr Val 
            340                 345                 350         


Val Ala Thr His Gly Ile Phe Thr Gly Asp Cys Leu Glu Glu Leu Glu 
        355                 360                 365             


Lys Ser Asp Ala Ile Asp Thr Ile Val Val Thr Asn Thr Tyr Pro Ile 
    370                 375                 380                 


Ser Gly Glu Arg Ile Ala Gly Ser Lys Lys Leu Val Thr Ile Asp Val 
385                 390                 395                 400 


Ser Pro Ile Phe Ala Glu Cys Ile Arg Arg Asp His Tyr Gly Glu Ser 
                405                 410                 415     


Ile Ser Val Leu Phe Asp Ser Leu Ala Ala Leu 
            420                 425         


<210>  45
<211>  320
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  45

Met Pro Thr Asn Ser Ile Lys Leu Leu Ala Pro Asp Val His Arg Gly 
1               5                   10                  15      


Leu Ala Glu Leu Val Ala Lys Arg Leu Gly Leu Gln Leu Thr Ser Ser 
            20                  25                  30          


Lys Leu Lys Arg Asp Pro Thr Gly Glu Val Ser Phe Ser Ile Gly Glu 
        35                  40                  45              


Ser Val Arg Asp Gln Asp Ile Phe Ile Ile Thr Gln Ile Gly Ser Gly 
    50                  55                  60                  


Val Val Asn Asp Arg Val Leu Glu Leu Leu Ile Met Ile Asn Ala Ser 
65                  70                  75                  80  


Lys Thr Ala Ser Ala Arg Arg Ile Thr Ala Ile Ile Pro Asn Phe Pro 
                85                  90                  95      


Tyr Ala Arg Gln Asp Arg Lys Asp Lys Ser Arg Ala Pro Ile Thr Ala 
            100                 105                 110         


Lys Leu Met Ala Asp Met Leu Thr Thr Ala Gly Cys Asp His Val Ile 
        115                 120                 125             


Thr Met Asp Leu His Ala Ser Gln Ile Gln Gly Phe Phe Asp Val Pro 
    130                 135                 140                 


Val Asp Asn Leu Tyr Ala Glu Pro Ser Val Val Arg Tyr Ile Lys Glu 
145                 150                 155                 160 


Asn Val Asn Tyr Met Asp Ser Ile Ile Ile Ser Pro Asp Ala Gly Gly 
                165                 170                 175     


Ala Lys Arg Ala Ala Thr Leu Ala Asp Arg Leu Asp Leu Asn Phe Ala 
            180                 185                 190         


Leu Ile His Lys Glu Arg Ala Arg Ala Asn Glu Val Ser Arg Met Val 
        195                 200                 205             


Leu Val Gly Asp Val Thr Asp Lys Ile Cys Ile Ile Val Asp Asp Met 
    210                 215                 220                 


Ala Asp Thr Cys Gly Thr Leu Ala Lys Ala Ala Glu Ile Leu Leu Glu 
225                 230                 235                 240 


Asn Arg Ala Lys Ser Val Ile Ala Ile Val Thr His Gly Val Leu Ser 
                245                 250                 255     


Gly Arg Ala Ile Glu Asn Ile Asn Asn Ser Lys Leu Asp Arg Val Val 
            260                 265                 270         


Cys Thr Asn Thr Val Pro Phe Glu Glu Lys Ile Lys Lys Cys Pro Lys 
        275                 280                 285             


Leu Ala Val Ile Asp Ile Ser Ser Val Leu Ala Glu Ser Ile Arg Arg 
    290                 295                 300                 


Leu His Asn Gly Glu Ser Ile Ser Tyr Leu Phe Lys Asn Tyr Pro Leu 
305                 310                 315                 320 


<210>  46
<211>  335
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  46

Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu 
1               5                   10                  15      


Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp 
            20                  25                  30          


Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro 
        35                  40                  45              


Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile 
    50                  55                  60                  


Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu 
65                  70                  75                  80  


Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu 
                85                  90                  95      


Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg 
            100                 105                 110         


Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile 
        115                 120                 125             


Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys 
    130                 135                 140                 


Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu 
145                 150                 155                 160 


Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln 
                165                 170                 175     


Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val 
            180                 185                 190         


Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys 
        195                 200                 205             


Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr 
    210                 215                 220                 


Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg 
225                 230                 235                 240 


Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile 
                245                 250                 255     


Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro 
            260                 265                 270         


Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile 
        275                 280                 285             


Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp 
    290                 295                 300                 


Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala 
305                 310                 315                 320 


Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala 
                325                 330                 335 


<210>  47
<211>  603
<212>  PRT
<213>  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

<400>  47

Met Pro Arg Asn Pro Leu Lys Lys Glu Tyr Trp Ala Asp Val Val Asp 
1               5                   10                  15      


Gly Phe Lys Pro Ala Thr Ser Pro Ala Phe Glu Asn Glu Lys Glu Ser 
            20                  25                  30          


Thr Thr Phe Val Thr Glu Leu Thr Ser Lys Thr Asp Ser Ala Phe Pro 
        35                  40                  45              


Leu Ser Ser Lys Asp Ser Pro Gly Ile Asn Gln Thr Thr Asn Asp Ile 
    50                  55                  60                  


Thr Ser Ser Asp Arg Phe Arg Arg Asn Glu Asp Thr Glu Gln Glu Asp 
65                  70                  75                  80  


Ile Asn Asn Thr Asn Leu Ser Lys Asp Leu Ser Val Arg His Leu Leu 
                85                  90                  95      


Thr Leu Ala Val Gly Gly Ala Ile Gly Thr Gly Leu Tyr Val Asn Thr 
            100                 105                 110         


Gly Ala Ala Leu Ser Thr Gly Gly Pro Ala Ser Leu Val Ile Asp Trp 
        115                 120                 125             


Val Ile Ile Ser Thr Cys Leu Phe Thr Val Ile Asn Ser Leu Gly Glu 
    130                 135                 140                 


Leu Ser Ala Ala Phe Pro Val Val Gly Gly Phe Asn Val Tyr Ser Met 
145                 150                 155                 160 


Arg Phe Ile Glu Pro Ser Phe Ala Phe Ala Val Asn Leu Asn Tyr Leu 
                165                 170                 175     


Ala Gln Trp Leu Val Leu Leu Pro Leu Glu Leu Val Ala Ala Ser Ile 
            180                 185                 190         


Thr Ile Lys Tyr Trp Asn Asp Lys Ile Asn Ser Asp Ala Trp Val Ala 
        195                 200                 205             


Ile Phe Tyr Ala Thr Ile Ala Leu Ala Asn Met Leu Asp Val Lys Ser 
    210                 215                 220                 


Phe Gly Glu Thr Glu Phe Val Leu Ser Met Ile Lys Ile Leu Ser Ile 
225                 230                 235                 240 


Ile Gly Phe Thr Ile Leu Gly Ile Val Leu Ser Cys Gly Gly Gly Pro 
                245                 250                 255     


His Gly Gly Tyr Ile Gly Gly Lys Tyr Trp His Asp Pro Gly Ala Phe 
            260                 265                 270         


Val Gly His Ser Ser Gly Thr Gln Phe Lys Gly Leu Cys Ser Val Phe 
        275                 280                 285             


Val Thr Ala Ala Phe Ser Tyr Ser Gly Ile Glu Met Thr Ala Val Ser 
    290                 295                 300                 


Ala Ala Glu Ser Lys Asn Pro Arg Glu Thr Ile Pro Lys Ala Ala Lys 
305                 310                 315                 320 


Arg Thr Phe Trp Leu Ile Thr Ala Ser Tyr Val Thr Ile Leu Thr Leu 
                325                 330                 335     


Ile Gly Cys Leu Val Pro Ser Asn Asp Pro Arg Leu Leu Asn Gly Ser 
            340                 345                 350         


Ser Ser Val Asp Ala Ala Ser Ser Pro Leu Val Ile Ala Ile Glu Asn 
        355                 360                 365             


Gly Gly Ile Lys Gly Leu Pro Ser Leu Met Asn Ala Ile Ile Leu Ile 
    370                 375                 380                 


Ala Val Val Ser Val Ala Asn Ser Ala Val Tyr Ala Cys Ser Arg Cys 
385                 390                 395                 400 


Met Val Ala Met Ala His Ile Gly Asn Leu Pro Lys Phe Leu Asn Arg 
                405                 410                 415     


Val Asp Lys Arg Gly Arg Pro Met Asn Ala Ile Leu Leu Thr Leu Phe 
            420                 425                 430         


Phe Gly Leu Leu Ser Phe Val Ala Ala Ser Asp Lys Gln Ala Glu Val 
        435                 440                 445             


Phe Thr Trp Leu Ser Ala Leu Ser Gly Leu Ser Thr Ile Phe Cys Trp 
    450                 455                 460                 


Met Ala Ile Asn Leu Ser His Ile Arg Phe Arg Gln Ala Met Lys Val 
465                 470                 475                 480 


Gln Glu Arg Ser Leu Asp Glu Leu Pro Phe Ile Ser Gln Thr Gly Val 
                485                 490                 495     


Lys Gly Ser Trp Tyr Gly Phe Ile Val Leu Phe Leu Val Leu Ile Ala 
            500                 505                 510         


Ser Phe Trp Thr Ser Leu Phe Pro Leu Gly Gly Ser Gly Ala Ser Ala 
        515                 520                 525             


Glu Ser Phe Phe Glu Gly Tyr Leu Ser Phe Pro Ile Leu Ile Val Cys 
    530                 535                 540                 


Tyr Val Gly His Lys Leu Tyr Thr Arg Asn Trp Thr Leu Met Val Lys 
545                 550                 555                 560 


Leu Glu Asp Met Asp Leu Asp Thr Gly Arg Lys Gln Val Asp Leu Thr 
                565                 570                 575     


Leu Arg Arg Glu Glu Met Arg Ile Glu Arg Glu Thr Leu Ala Lys Arg 
            580                 585                 590         


Ser Phe Val Thr Arg Phe Leu His Phe Trp Cys 
        595                 600             


<210>  48
<211>  417
<212>  PRT
<213>  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

<400>  48

Met Ala Leu Leu Pro Phe Phe Asp Leu Thr Asn Phe Glu Ser Asp Ala 
1               5                   10                  15      


Ser Glu Glu Leu Gly Trp Leu Lys Tyr Val Gly Arg Val Gln Thr Arg 
            20                  25                  30          


Val Phe Pro Gln His Phe Lys Asp Asn Leu Glu Lys Val Arg Lys Ile 
        35                  40                  45              


Ser Glu Thr Ile Asp Val Ile Val Asp Thr Thr Ala Glu Leu Gly Pro 
    50                  55                  60                  


Glu Ala Cys Val Asn Leu Leu Asn Ala Gly Ala Leu Ala Ile Leu Val 
65                  70                  75                  80  


Asn Glu Glu Met Leu Asn Glu Leu Ala Asp Ile Ser Pro Asn Arg Leu 
                85                  90                  95      


Val Leu Lys Thr Asp Thr Thr Asp Ile Gly Lys Ile Glu Lys Leu Ser 
            100                 105                 110         


Gln Val Ala Gly Ser Ile Gln Trp Ile Gly Ser Ala Glu Asn Tyr Pro 
        115                 120                 125             


Pro Asp Phe Phe Glu Arg Ala Ser Lys Ile Ile His Lys Ala Val Met 
    130                 135                 140                 


Pro Glu Gly Gly Gly Arg Thr Leu Tyr Leu Glu Phe Pro Glu Gln Pro 
145                 150                 155                 160 


Ser Met Glu Val Leu Lys Ser Phe Ser Val His Ser Val Val Pro Val 
                165                 170                 175     


Leu Ser Ser Ser Phe Leu Thr Val Lys Pro Ala Glu Glu Pro Lys Lys 
            180                 185                 190         


Leu Ser Leu Ala Asp Leu Ile Leu Ile Ser Ala Asn Thr Asp Arg Glu 
        195                 200                 205             


Asp Gly Leu Phe Ser Thr Leu Val Val Asn Glu Leu Gly Ile Ala Leu 
    210                 215                 220                 


Gly Leu Val Tyr Ser Ser Lys Glu Ser Val Ala Glu Ser Leu Lys Thr 
225                 230                 235                 240 


Gly Thr Gly Val Tyr Gln Ser Arg Lys Arg Gly Leu Trp Tyr Lys Gly 
                245                 250                 255     


Ala Ser Ser Gly Ala Val Gln His Leu Ile His Ile Asp Val Asp Cys 
            260                 265                 270         


Asp Glu Asp Cys Leu Arg Phe Val Val Tyr Gln Thr Gly Lys Gly Phe 
        275                 280                 285             


Cys His Leu Asp Thr Leu His Cys Phe Gly Gln Ala Ser Gly Leu Cys 
    290                 295                 300                 


Gln Leu Glu Lys Thr Leu Ile Asp Arg Lys Asn Asn Ala Pro Glu Gly 
305                 310                 315                 320 


Ser Tyr Thr Ala Arg Leu Phe Ser Asp Pro Lys Leu Leu Arg Ala Lys 
                325                 330                 335     


Ile Met Glu Glu Ala Glu Glu Leu Cys Asp Ala Thr Thr Lys Glu Asn 
            340                 345                 350         


Val Ile Trp Glu Met Ala Asp Leu Met Tyr Phe Ala Ile Thr Arg Cys 
        355                 360                 365             


Val Gly Ser Gly Val Ser Leu Asn Asp Ile Ser Arg His Leu Asp Leu 
    370                 375                 380                 


Lys His Arg Lys Val Thr Arg Arg Lys Gly Asp Ala Lys Val Ala Trp 
385                 390                 395                 400 


Gln Glu Lys Leu Lys Asp Lys Gly Gly Val Ala Asn Thr Ser Tyr Thr 
                405                 410                 415     


Ala 
    


<210>  49
<211>  316
<212>  PRT
<213>  Oenococcus oeni (Leuconostoc oenos)

<400>  49

Met Ser Glu Phe Asp Lys Lys Leu Asn Thr Leu Gly Val Asp Arg Ile 
1               5                   10                  15      


Ser Val Ser Pro Tyr Lys Lys Trp Ser Arg Gly Tyr Leu Glu Pro Gly 
            20                  25                  30          


Asn Val Gly Asn Gly Tyr Val Ser Gly Leu Lys Val Asp Ala Gly Val 
        35                  40                  45              


Ile Asp Lys Thr Asp Asp Met Ile Leu Asp Gly Ile Val Ser Tyr Asp 
    50                  55                  60                  


Arg Ala Glu Thr Lys Asn Ala Tyr Ile Gly Gln Ile Asn Met Thr Thr 
65                  70                  75                  80  


Ala Ser Ser Phe Ser Gly Val Gly Gly Thr Val Leu Gly Tyr Asp Ile 
                85                  90                  95      


Leu Arg Asn Pro Glu Val Asp Lys Ala Lys Pro Leu Phe Thr Glu Lys 
            100                 105                 110         


Gln Trp Asp Gly Ser Glu Leu Pro Ile Tyr Asp Ala Lys Pro Leu Gln 
        115                 120                 125             


Asp Thr Leu Val Glu Tyr Phe Gly Thr Lys Asp Asp Met Arg His Tyr 
    130                 135                 140                 


Pro Ala Pro Gly Ala Phe Val Cys Cys Ala Asn Lys Gly Val Thr Ala 
145                 150                 155                 160 


Glu Arg Pro Lys Asn Asp Ala Asp Met Lys Pro Gly Gln Gly Tyr Gly 
                165                 170                 175     


Val Trp Ser Ala Ile Ala Ile Ser Phe Ala Lys Asp Pro Thr Lys Tyr 
            180                 185                 190         


Ser Ser Met Tyr Val Glu Asp Ala Gly Val Trp Glu Thr Pro Asn Glu 
        195                 200                 205             


Asp Glu Leu Ile Glu Tyr Leu Lys Gly Arg Arg Asn Ala Met Ala Lys 
    210                 215                 220                 


Ser Ile Ala Ala Cys Gly Glu Asn Thr Ala Ala Glu Asn Gly Gly Ala 
225                 230                 235                 240 


Val Phe Thr Ser Ser Trp Ile Gly Phe Ala His Ala Met Met Lys Pro 
                245                 250                 255     


Gly Gln Val Gly Asn Ala Ile Thr Val Ala Pro Tyr Ile Ala Met Pro 
            260                 265                 270         


Val Asp Ser Ile Pro Gly Gly Ser Ile Leu Thr Pro Asp Thr Asp Met 
        275                 280                 285             


Asp Ile Met Gln Asn Leu Thr Met Pro Glu Trp Leu Asp Lys Met Gly 
    290                 295                 300                 


Tyr Gln Pro Leu Thr Lys Gly Gly Asn Ile Asn Tyr 
305                 310                 315     


<210>  50
<211>  283
<212>  PRT
<213>  Lactobacillus aviarius subsp. aviarius DSM 20655

<400>  50

Met Glu Pro Gly Asn Ile Gly Asn Gly Tyr Val Thr Gly Leu Lys Val 
1               5                   10                  15      


Asp Ala Gly Val Arg Asp Lys Thr Asp Asp Asp Val Leu Asp Gly Ile 
            20                  25                  30          


Val Ser Tyr Asp Arg Ala Glu Thr Lys Asn Ala Tyr Ile Gly Gln Ile 
        35                  40                  45              


Asn Met Thr Thr Ala Ser Ser Phe Thr Gly Pro Gln Gly His Val Val 
    50                  55                  60                  


Gly Tyr Asp Ile Leu Arg Asn Pro Glu Val Asp Lys Val Lys Pro Leu 
65                  70                  75                  80  


Phe Val Glu Lys Gln Trp Asp Gly Ser Asp Leu Pro Ile Tyr Asp Ala 
                85                  90                  95      


Lys Pro Leu Gln Asp Ala Leu Val Glu Tyr Phe Gly Met Glu Gln Glu 
            100                 105                 110         


Arg Arg His Tyr Pro Ala Pro Gly Ser Phe Ile Val Cys Ala Asn Lys 
        115                 120                 125             


Gly Val Thr Ala Glu Arg Pro Lys Ala Asp Glu Pro Leu Lys Pro Gly 
    130                 135                 140                 


Gln Gly Tyr Gly Val Trp Ser Ala Ile Ala Ile Ser Phe Ala Lys Asp 
145                 150                 155                 160 


Pro Ser Lys Asn Ser Ser Met Phe Ile Glu Asp Ala Gly Val Trp Glu 
                165                 170                 175     


Thr Pro Asn Glu Asp Glu Leu Ile Glu Tyr Leu Asn Gly Arg Arg Lys 
            180                 185                 190         


Ala Ile Ala Lys Ser Ile Ala Glu Cys Gly Gln Asp Ala Asp Thr Ala 
        195                 200                 205             


Phe Glu Ser Ser Trp Ile Gly Phe Ala His Val Met Met Lys Pro Gly 
    210                 215                 220                 


Gln Ile Gly Asn Ala Ile Thr Val Gly Pro Tyr Phe Ser Leu Pro Val 
225                 230                 235                 240 


Asp Ser Ile Pro Asn Gly Ser Ile Leu Thr Pro Asp Lys Asp Met Glu 
                245                 250                 255     


Ile Met Glu Asn Leu Ser Leu Pro Glu Trp Leu Asp Lys Met Gly Tyr 
            260                 265                 270         


Glu Ser Leu Val Lys Lys Asn Asn Val Thr Tyr 
        275                 280             


<210>  51
<211>  387
<212>  PRT
<213>  Chromobacterium sp. LK1

<400>  51

Met Ser Leu Ser Pro Leu Asp Gln Asn Arg Ile Glu Ser Phe Trp Gln 
1               5                   10                  15      


Tyr Cys Leu Gln His Gln Tyr Phe Asn Leu Ala Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ala Pro Leu His Arg Phe Leu Arg Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Asn Glu Ser Ser Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Arg Glu Val Met His Phe Phe Ala Glu Leu Phe His Ile 
65                  70                  75                  80  


Pro Phe Asp Glu Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Ala Arg Glu Leu Phe Pro Asp Ala Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Ser His Tyr Ser Val Ala Lys Ile Ile Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Ser Arg Ala Val Asp Ser Leu Pro Ser Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Val Ala Lys Ile Gln Gln Asp Gln Glu Arg 
145                 150                 155                 160 


His Pro Ile Val Phe Val Asn Val Gly Thr Thr Met Lys Gly Ala Val 
                165                 170                 175     


Asp Asp Ile Gly Val Ile Gln His Lys Leu Ala Glu Ala Gly Ile Pro 
            180                 185                 190         


Arg Gln Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp Ala Pro Gln Pro Tyr Ser Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Ser Val Ser Gly His Lys Met Ile Gly Ser Pro Met Pro 
225                 230                 235                 240 


Cys Gly Ile Val Leu Ala Lys Arg Ser Asn Val Ser Arg Ile Ser Val 
                245                 250                 255     


Glu Ile Asp Tyr Ile Ser Ala Lys Asp Gln Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Met Met Leu Trp Ala Ala Ile Lys Ser Arg Pro 
        275                 280                 285             


Leu Ala Glu Trp Arg Arg Lys Val Arg His Cys Leu Asp Met Ala Gln 
    290                 295                 300                 


Tyr Ala Ile Asp Arg Leu Gln Ala Ala Gly Ile Gln Ala Trp Arg Cys 
305                 310                 315                 320 


Lys Asn Ser Ile Thr Val Val Phe Pro Ser Pro Ser Glu Pro Val Cys 
                325                 330                 335     


Asp Lys His Gly Leu Ala Arg Ser Gly Gly Thr Ala His Leu Ile Thr 
            340                 345                 350         


Thr Pro His His His Asp Ser Gln Arg Leu Asp Arg Leu Leu Asp Asp 
        355                 360                 365             


Ile Val Gln Asp Leu Gly Ala Met Thr Ala Pro Ala Gly Ala Thr Met 
    370                 375                 380                 


Ser Ala Ala 
385         


<210>  52
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  52
atgattctgt cccccgccga ccaagaaaga attgagacct tctggaatta ctgcctgaaa       60

catcagtact ttaacattgg ttaccctgag tctgccgact tcgattactc cgccctgttt      120

cggttcttca aattttctat taacaactgc ggcgactgga aggactactc caactacgcc      180

ctgaactcct ttgactttga gaaggacgtt atggcttatt tcgctgagat ctttcagatc      240

cccttcgaag agtcgtgggg atatgtcacc aatggtggca cagaaggcaa catgtttggt      300

tgttaccttg caagagagct ctttagcgat tcgaccctct actactctaa ggatacacac      360

tattccgtgg gcaagatcgc caagcttctt cagatgaaat cgtgcgtcat cgaatcgctc      420

gacaacggcg aaattgacta cgacgacctc attcacaaga tcaagacaaa taaggaatcg      480

catcctatca tctttgccaa cattggtaca actatgactg gcgctattga cgacattgag      540

atgatccagg agcgactcgc tcagatcgga attatgcgac gagattacta catccacgct      600

gacgcagccc tgtctggtat gattctgcct ttcgtcgacc atcctcaggc cttctctttt      660

gctcatggta tcgatagcat ctgcgtgtcg ggacataaga tgatcggatc ccctattcct      720

tgtggtattg tcgtcgctaa gcggcagaat gtggagcgaa tttccgtgga cgtggattac      780

atctctacac gagatcaaac tatttctggt tctcgaaacg gccataccgt gctgctgatg      840

tgggcagcca tccgttcgca gaccaacctc cagagacgac aacgaatcca gcactgtctg      900

aaaatggctc agtatgctgt cgatcgattt caagctgtcg gaatccctgc ctggcgaaac      960

cccaattcca tcactgtcgt ttttccctgt ccttctgagc acatttggaa gaagcactac     1020

ctggcaacat ctggcaacat ggctcacctt atcaccacag cccaccaccg agatacgcga     1080

cagattgact ctctcatcga tgacgtcatt tttgatcttc aaggtgcttc caagcgaacc     1140

gtcggcttc                                                             1149


<210>  53
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  53
atggatctcg tcaaccatct gaccgaccgt ctcctgttcg ctatccccaa aaagggtcgg       60

ctctattcca agtctgtgtc gatcctcaac ggagctgaca ttacgtttca tcgatctcaa      120

cggctggata ttgctctctc cacgtccctg cctgtcgccc tgattttcct gcctgccgct      180

gacattccca ctttcgtggg cgagggtaag tgtgacctcg gtatcaccgg tgtcgatcag      240

gtgagagagt ctgacgtcga cgtggacctg gccatcgatc tgcagttcgg aaactgcaag      300

cttcaggtgc aggtgcctgt gaacggtgag tacaagaagc ctgagcagct gatcggtaag      360

accatcgtca catcctttgt taagctggca gagaaatact ttgctgacct ggagggcact      420

accgtcgaga agatgaccac ccgaatcaaa ttcgtttcgg gttctgtcga ggcttcctgc      480

gctctgggca tcggtgacgc cattgtcgac cttgttgagt ctggagagac catgagagcc      540

gctggactgg tggacattgc caccgttctg tcgacttcgg cctaccttat cgagtctaag      600

aaccccaaga gcgacaagtc cctgatcgca actattaaga gcagaattga gggtgttatg      660

acagcacagc ggtttgtgtc ctgcatctat aatgctcccg aggataaact tcccgaactg      720

ctcaaggtta cgcccggcag acgagccccc accatcagca agatcgacga tgagggttgg      780

gtcgccgttt cgtctatgat cgagagaaag acaaagggag tggtcctgga cgagcttaag      840

cgactgggtg cctctgacat tatggtcttt gagatttcca actgcagagt c               891


<210>  54
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  54
atgattcttt caccggcgga tcaggaacgc attgagacct tctggaacta ctgcctgaaa       60

caccagtact tcaatatcgg ctatccagaa tcagcagatt tcgattacag cgcgctgttc      120

cgtttcttca aattttcgat aaataactgc ggagactgga aggactattc gaattacgcc      180

ttaaattcat ttgatttcga gaaagatgtg atggcctact tcgctgaaat ctttcaaatt      240

ccgttcgaag aatcatgggg ctatgtaaca aacggcggta ctgagggaaa catgtttggc      300

tgttatctgg caagagaact cttttccgat tcaaccctgt actattcaaa agatacacac      360

tattcagtcg gcaaaattgc gaaattactt caaatgaaaa gttgtgtcat tgagagttta      420

gataacggcg aaatcgacta tgatgattta atacataaaa ttaaaacaaa taaagaatca      480

catccaatca tatttgcgaa tatcggaact acaatgacgg gagctattga cgacatcgag      540

atgatacaag agagattagc acaaattgga attatgcgcc gcgattacta tattcacgca      600

gacgcggcct tgtcagggat gatacttcct tttgttgatc acccgcaggc attttctttc      660

gcgcatggta tcgatagcat ctgtgtttca ggacataaaa tgattgggag cccgatccca      720

tgtggtattg tcgtagcgaa aagacagaat gtcgaaagaa taagcgttga tgtggattac      780

attagcacac gcgaccagac aattagcggc tcacgtaacg gacatacagt cctgttaatg      840

tgggctgcta ttagatccca aactaattta caaagaagac aacgcatcca acattgcctt      900

aaaatggcac agtacgcggt agacagattt caagctgttg gaattccggc gtggagaaac      960

ccgaattcaa ttactgtagt ctttccgtgc ccttcggaac atatttggaa gaagcattat     1020

ttagcgacga gcgggaacat ggcccatctt atcacgacgg ctcaccacag agatacacgt     1080

caaattgatt ctttgattga tgatgtaatt ttcgatctgc aaggagccag taagagaacc     1140

gtgggattt                                                             1149


<210>  55
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  55
atggatttag ttaatcactt gaccgataga ttattgtttg cgattcctaa aaaaggtcgg       60

ctttactcca aaagcgtgag cattttaaat ggcgcagata ttacctttca tagatctcag      120

cgtctggata tagcgctctc cacaagcctg ccggtggcgc ttatattctt accggcggca      180

gacatcccta ctttcgtggg ggaaggaaag tgcgacctcg gaatcacagg agtagatcaa      240

gttcgcgaat cggatgtaga tgttgacctt gccatcgatt tacaatttgg aaattgcaag      300

ctccaagttc aggtacctgt gaacggagaa tataagaagc cggaacagtt aattggcaaa      360

actattgtca cttcttttgt aaagctggcg gaaaaatatt tcgcggactt ggaaggtaca      420

accgtcgaaa aaatgactac acggatcaaa tttgtaagcg ggtctgttga agcaagctgc      480

gctctgggta ttggtgacgc gatagtggac ctggtggaaa gtggggaaac gatgcgagca      540

gcaggattgg tagatatcgc tacagtgtta tcaactagtg catacctgat agaatccaaa      600

aaccctaaat cggataaatc gcttatcgcc acaataaaat cacgcattga aggagtaatg      660

acggctcaac gatttgtgtc ctgcatatat aacgctcctg aggataaatt gccggagctg      720

ctgaaggtga caccgggccg gagagccccg accataagca aaatagacga cgagggctgg      780

gttgccgtaa gcagtatgat cgaacgcaag acgaagggag tagttttgga cgaacttaag      840

cgcttagggg catccgatat aatggtgttt gaaattagca actgtagagt c               891


<210>  56
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  56
atgatcctat ctcctgctga ccaagaaaga attgaaacct tttggaacta ctgtttgaaa       60

catcaatact tcaacatcgg ttaccctgag agcgcagact ttgactatag tgcattattt      120

agatttttca aattctctat taacaactgc ggagactgga aagattactc caattacgct      180

ttaaactcct ttgattttga gaaggatgtg atggcatact ttgcagaaat attccaaatt      240

cctttcgaag aaagctgggg atacgttaca aatggtggta cagaaggtaa catgttcggt      300

tgttacttag cgagagaatt gttcagtgac tccacattgt attatagcaa agacactcat      360

tactcagtag gtaagattgc caaacttttg caaatgaagt catgcgtcat agaatcttta      420

gacaatgggg aaatagacta cgatgatctg atccataaga ttaaaactaa caaggaaagc      480

catccaatca tattcgcaaa tattggaaca acaatgacag gagcaatcga cgacatcgaa      540

atgatacaag aaagattagc ccaaataggc ataatgcgta gagactatta catacatgct      600

gacgcagcat tgagtggtat gattttgcct tttgtcgatc acccacaggc gttcagtttt      660

gctcatggta tcgatagtat atgtgtctcc ggacacaaga tgattggctc accgattcca      720

tgcggcattg ttgttgcaaa aagacagaac gtcgaaagaa ttagtgtgga cgtcgactat      780

atatcaacca gagaccaaac cattagcggt tcaagaaatg gccacacagt acttctgatg      840

tgggccgcga ttcgtagtca aacgaactta caaagaaggc aaagaattca acattgttta      900

aagatggcgc aatacgccgt cgacagattt caggctgtag gtatacctgc gtggagaaat      960

ccaaattcaa ttaccgtggt ttttccatgt ccttctgaac atatctggaa aaaacattac     1020

ttagccacta gcggtaacat ggcacaccta atcactaccg cccatcatag agatacaaga     1080

caaattgatt ccttaattga tgatgtcatt tttgacttac agggagcttc taagaggacc     1140

gttggtttc                                                             1149


<210>  57
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  57
atggatttgg tcaaccacct tactgacagg cttttgttcg ccattccaaa gaaaggcagg       60

ttatactcca aatctgtttc aatactaaat ggagcagaca ttacttttca tcgtagccag      120

agactagata ttgctttatc aacctcactt ccagtagcac ttattttttt acccgcagca      180

gatataccaa catttgtagg tgagggtaag tgtgatttag gtattacagg ggttgaccaa      240

gttagagaaa gcgatgtcga tgtagacctt gctatcgact tgcagttcgg aaattgcaag      300

ttacaagtgc aggtgccagt taatggcgag tataagaagc cggaacagtt aataggaaaa      360

acaatagtta cctcttttgt gaagttagct gaaaaatact ttgccgactt agaaggtacg      420

actgtggaaa aaatgacaac aagaattaag tttgttagtg gttctgtcga agcatcctgc      480

gcactaggaa ttggtgatgc tattgtagac ttagtagaga gtggagaaac aatgagggcc      540

gcaggtttgg tagatattgc taccgtatta tcaacatccg catatcttat tgagtctaaa      600

aatcctaaat ccgacaaaag tttgatcgct actataaagt caaggattga gggtgtcatg      660

acagctcaga gatttgtatc atgcatctat aatgctcccg aagacaagct gcctgaatta      720

ctaaaggtaa caccgggaag aagggcacca actatcagca agattgatga tgaaggatgg      780

gtcgccgttt catcaatgat tgaaagaaag acaaaaggtg tggttcttga cgaacttaaa      840

cgtttgggag ccagtgatat catggtcttc gaaatttcta attgccgtgt g               891


<210>  58
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  58
atgctggaca acacaagact gcgaattgcc atccagaagt ctggtagact cagcgatgat       60

tccagagagc ttctggcccg ttgtggcatt aaaatcaacc ttcatactca gcggctcatc      120

gccatggccg aaaacatgcc tatcgatatt cttagagtcc gagatgatga catccctgga      180

ctggtcatgg acggcgtcgt cgatctgggt attattggcg aaaacgtgct cgaggaagag      240

ctcctcaacc gacgtgccca gggagaggat ccccgatacc tcaccctccg aagactcgac      300

ttcggaggct gccgactctc gcttgccacc cccgtcgacg aggcttggga cggacctgcc      360

gcccttgatg gtaagcgaat tgccacctct tacccccacc tgctcaagcg ttacctggat      420

cagaagggag tctcgttcaa gtcgtgcctg cttaacggta gcgtcgaggt ggctccccga      480

gctggcctcg ccgacgccat ttgtgatctg gtctccactg gcgccaccct cgaagccaat      540

ggtcttcggg aggttgaggt gatttaccga tccaaggctt gtctcattca gcgagatggc      600

gagatggccc aatccaaact gattgacaag ctcctgaccc gaattcaggg agtgatccag      660

gcccgagaat cgaagtacat catgatgcac gccccttccg aacgactcga ggaggtcatc      720

gccctgcttc ccggcgctga gcgtcccacc attcttcccc tggctggtga gcaacagcga      780

gttgccatgc acatggtttc ctcggaaact cttttttggg agacaatgga gaagctcaag      840

gccctcggcg cctcgtctat cctcgtcctt cctatcgaga agatgatgga g               891


<210>  59
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  59
atgttggata acacacgcct gagaatagcc attcagaagt ctggtagatt gtcagacgat       60

agtcgggaat tgctggctcg gtgtggaatt aagattaacc tgcatacgca gcgcctgatc      120

gcgatggctg aaaatatgcc aattgatatt cttcgtgtga gagacgatga tattccaggt      180

ttagtaatgg atggcgttgt cgatcttggc atcataggag aaaatgttct ggaggaggaa      240

ttattgaacc ggcgcgcaca gggcgaggat cctcgatatt taacattacg gcgactggac      300

tttggtggat gccggttgag cttagcgacg ccagtcgacg aggcttggga tggaccggct      360

gctttggatg gaaaacgtat tgcgacctca taccctcatc tgttaaaacg ctatcttgac      420

cagaaaggag tatcctttaa atcatgtctg ctgaatggat ctgtggaggt ggcccctcgt      480

gcaggattgg ccgatgccat ctgcgatctt gtgagcacag gtgcaactct tgaggcaaat      540

gggctcagag aagtcgaagt aatttaccgt agcaaagctt gcctgatcca gcgcgatgga      600

gaaatggcgc agtctaagtt aattgacaaa ttgctgactc gaatacaagg agttatccaa      660

gctagagaat ctaaatacat catgatgcat gctccatctg agcgactgga ggaagtaatt      720

gcgcttcttc ctggggcgga aagaccgact atcttgccgt tagcaggtga acaacagcgg      780

gttgccatgc acatggtttc ctctgaaact ctgttttggg aaaccatgga aaaactgaaa      840

gcgttgggag cgtcctctat ccttgttctt cctatcgaga aaatgatgga a               891


<210>  60
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  60
atgctggaca atacaagatt aagaatagca atacagaaat caggtagact gtcagacgat       60

agccgtgagc ttttagccag atgtggcata aaaattaatt tgcacacaca aaggcttatt      120

gccatggccg aaaatatgcc gatagacata ttaagagtga gagatgatga tatacccggg      180

ttggttatgg atggtgttgt cgatttgggt atcattggtg agaacgtgtt ggaagaagaa      240

ctgttaaaca gaagagctca gggagaggac cccagatatt taactttaag gcgtctggat      300

tttggtggtt gtcgtctttc cttagccaca ccagtagacg aagcttggga tggtccagca      360

gcactagacg gtaaaaggat tgcgacatcc tacccacatt tgctaaagcg ttatttggac      420

caaaaaggcg tttcttttaa gtcttgtcta ttaaatggct cagtagaagt ggctcctaga      480

gctggtctgg ctgatgcaat ctgtgattta gtgtctacag gtgcaacact agaagctaac      540

ggcttaagag aagtggaggt catttatagg tcaaaggctt gtttgatcca aagagacgga      600

gaaatggccc aatcaaaatt aattgataaa ctgcttacta gaattcaagg tgtgatccaa      660

gcaagagaat ccaaatatat catgatgcat gcaccgtcag agcgtctgga ggaggtgatc      720

gccttgttac caggtgcgga aagaccaacg attttgcccc ttgctggtga acaacaaaga      780

gtggccatgc acatggtatc ctctgaaacg ttattctggg agacgatgga aaaattaaag      840

gcattaggtg caagttctat attagtactg ccaatagaaa agatgatgga g               891


<210>  61
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  61
atgatcctta gccctgccga ccaagaacgt atcgaaactt tctggaacta ctgcttgaaa       60

catcagtact ttaacatcgg atatccggag tctgccgact ttgactacag cgcacttttc      120

cgattcttca agttctcaat caacaattgc ggtgactgga aggattattc caactacgcc      180

ctgaactctt tcgatttcga aaaagatgta atggcatatt tcgcagagat cttccagatt      240

ccctttgaag aatcgtgggg ctacgtcacc aatggcggca ccgaaggcaa tatgttcgga      300

tgttacctgg ctcgcgaact cttttccgat tccacacttt attattcgaa ggatacccac      360

tactcggtgg gcaaaatcgc aaagctcctc cagatgaagt cctgtgttat cgaatctctt      420

gataacggtg aaatcgacta cgacgatttg attcataaaa tcaaaaccaa caaggagtct      480

catccaatta tttttgctaa cattggaacc accatgacgg gcgctattga cgatatcgaa      540

atgattcagg aacgcttggc ccagatcgga atcatgcgtc gagattacta tattcatgct      600

gatgccgcac tgtcgggtat gatcctccca ttcgtcgatc atccgcaagc cttttccttc      660

gcgcatggta tcgatagcat ctgtgtttcc ggccataaga tgattggctc gcccatcccc      720

tgcggcattg tggtggcaaa gcgccagaat gtcgagcgca tctccgtgga tgtggattat      780

atctctaccc gcgatcaaac catctcgggc tcccgcaacg gtcatactgt cttgctgatg      840

tgggcggcaa tccgttcaca aacgaacctc cagcgtcgcc agcgcatcca gcactgtctg      900

aaaatggcac aatacgcagt ggatcgcttt caagcagtcg gaattccagc atggcgcaac      960

ccgaactcca tcaccgttgt gttcccatgc ccgagcgaac acatctggaa gaagcactac     1020

ctggctacca gcggcaacat ggcccacctt atcaccactg cacatcaccg tgatactcgt     1080

cagatcgact cgctgatcga cgatgtgatc ttcgatctgc aaggtgcaag caaacgtact     1140

gtcggtttc                                                             1149


<210>  62
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  62
atgttggata acacacgcct gcgcatcgct atccagaagt caggtcgtct gtcggacgac       60

tcccgcgagc tcctcgctcg ctgtggcatt aaaatcaacc tgcataccca acgcctgatt      120

gcgatggctg agaacatgcc tatcgacatc cttcgtgtcc gcgatgatga cattccaggt      180

cttgtgatgg atggcgttgt cgacttgggc atcattggcg aaaacgtgct cgaggaagaa      240

ttgctgaatc gccgagcgca aggcgaggac cctcgctatc tgaccctccg tcgactggat      300

tttggtggct gccgcctctc tttggcaact ccggtggacg aggcatggga tggtcctgcc      360

gcccttgatg gtaaacgcat cgccacttct tacccccact tgttgaaacg ctatttggat      420

caaaaaggcg tttcttttaa gagctgtttg cttaacggct cagtggaggt cgctcctcgc      480

gccggactgg cagatgctat ctgtgacctt gtttctaccg gtgctacctt ggaagccaac      540

ggattgcgcg aggttgaagt catctaccgc tccaaggcgt gcctcattca gcgagatggt      600

gaaatggccc agtccaagct tatcgataaa ctgttgactc gcattcaggg cgtgattcag      660

gcgcgcgaat cgaaatatat catgatgcac gcgccttctg aacgcctgga agaagtgatt      720

gcactgctcc ctggagccga gcgcccaacc atcctgcctc tcgcgggtga gcaacaacgt      780

gtcgccatgc acatggtctc gtctgaaaca ctgttctggg agaccatgga gaaacttaaa      840

gcactgggcg cgtcctcaat ccttgtcctg cccattgaaa agatgatgga a               891


<210>  63
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  63
atgtccctgt ctcccctgga tcagaatcga attgagtcct tttggcagta ctgtctccag       60

caccaatact ttaacctcgc ttaccccgag tcggccgatt ttgactacgc ccctctgcac      120

cgattcctgc gattctccat caataactgc ggcgattgga acgagagctc caactacctc      180

cttaactcgt tcgacttcga gcgggaggtg atgcatttct tcgccgagct cttccatatt      240

cccttcgacg aaagctgggg ctacgtgacc aacggaggca ccgagggcaa tatgtttggt      300

tgctacctcg cccgagaact ctttcctgac gcaactctct actacagcaa ggacagccat      360

tactctgtgg ctaagatcat taagctgctg cgaatcaaaa gcagagcagt ggactccctg      420

ccctcgggtg agattgatta cgacgacctc gtggcaaaaa tccagcagga tcaggagcgg      480

caccctatcg tctttgtgaa cgtcggcaca accatgaagg gcgccgtcga tgacatcgga      540

gtcattcagc acaagcttgc tgaagccggc attccccggc aggactatta tctgcacgca      600

gatgctgctc tgtcgggcat gattcttccc tttgttgatg ccccccagcc ctacagcttt      660

gccgacggaa tcgactcgat ctccgtgtcg ggacacaaga tgatcggatc ccccatgccc      720

tgcggtattg tcctggctaa gcgttccaac gtctcgcgaa tttcggtcga gattgactac      780

atctctgcta aggaccagac catcagcggt tcccggaacg gtcacacccc catgatgctg      840

tgggccgcca tcaaatctcg acctctggct gagtggcgtc gtaaggtgcg acactgcctg      900

gatatggcac agtatgctat cgatcgactg caggccgccg gtattcaggc ttggcgatgc      960

aagaacagca ttacggttgt tttcccttcg ccatctgagc ccgtctgcga taagcatggc     1020

ctcgcacgat ctggtggtac agctcacctg attaccacgc ctcatcacca tgacagccaa     1080

cgactggacc ggcttctgga cgatatcgtt caggacctgg gagccatgac ggctcctgct     1140

ggcgctacca tgagcgccgc t                                               1161


<210>  64
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  64
atgctcaaga ttgcagtccc caacaagggt tcgctctccg agagagccat ggagattctg       60

gccgaggccg gctacgccgg cagaggagac tctaagtccc tcaacgtttt cgacgaggcc      120

aacaacgtcg agttcttctt cctccgaccc aaggatattg ctatctacgt tgccggtggc      180

cagctggatc tcggaatcac tggtagagac ctggcccgag attctcaagc cgatgtccac      240

gaagtcctgt ctctgggatt cggctcttcg acattccgat acgcagcccc tgctgacgag      300

gagtggtcga tcgagaagct cgatggcaag cgaatcgcca ccagctatcc aaatctggtt      360

cgagacgacc ttgcagcccg aggactctcg gctgaggtgc tgcgtctcga tggcgccgtc      420

gaggtctcca tcaagcttgg tgttgccgac gctattgctg acgtcgtctc cacgggccga      480

acactgcgac agcaaggtct tgcccctttc ggtgaggtgc tctgcacgtc cgaggccgtc      540

attgtcggac gaaaggatga gaaggtcact cctgaacaac agattctgct gcgtcgaatc      600

cagggtattc tgcatgctca gaacttcctc atgctcgatt acaaggtcga ccgggataac      660

ctcgatgccg ctactgccgt cactcccggc ttttctggac ctgccgtctc tcccctcgct      720

cgagacaact gggttgcagt cagagccatg gtgcctagaa gatctgctaa cgctattatg      780

gataagctcg ctggcctggg cgccgaagct atcctggcaa gcgagatcag aattgctcga      840

atc                                                                    843


<210>  65
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  65
atgtctctaa gtcccttgga ccagaatagg atcgaatctt tttggcaata ttgcttgcag       60

caccaatatt tcaacctggc ctatcctgaa agtgctgatt tcgattacgc acctcttcac      120

agattcttga ggttctctat taataattgc ggtgactgga acgaatcttc aaactacctt      180

ttaaattcct ttgattttga aagggaagtt atgcacttct tcgccgaatt attccacatt      240

ccatttgatg aatcttgggg ctatgtcacc aacggtggta ctgaaggcaa tatgttcgga      300

tgttatcttg cacgtgaatt gtttccagat gctactcttt actactccaa agactcacat      360

tattcagttg ccaagattat taaactgctt aggattaaat ctagagctgt ggacagtctg      420

ccgagtggag aaattgacta cgacgacttg gtggcgaaga tacagcaaga tcaagaacgt      480

catccgatcg ttttcgtcaa cgtcggcaca acaatgaagg gagcagtgga cgatataggc      540

gtgattcagc acaaattggc tgaggcaggc atacctcgtc aagattacta tttacatgcc      600

gacgcggcac tttctggcat gatactacca tttgttgatg ctcctcaacc atattctttt      660

gctgatggaa tcgatagcat atctgtatca gggcataaga tgataggttc cccaatgccg      720

tgtggtattg tgttggcgaa gagatctaac gttagcagaa tatctgttga aatagattac      780

atttcagcta aagatcaaac aattagtggt agtagaaacg gccatacacc aatgatgttg      840

tgggcagcca taaaaagcag accgttagcc gagtggaggc gtaaggttcg tcattgcttg      900

gatatggctc agtatgctat agatcgtctt caagccgctg gcattcaagc ttggagatgt      960

aaaaactcca tcactgtcgt tttcccttct ccatccgaac ctgtctgtga caaacacggc     1020

ctagccagaa gtggtggtac tgcacacctg attactacgc cacatcacca tgattctcag     1080

agattagata ggctacttga tgatatcgtt caggatttgg gcgctatgac tgctccagct     1140

ggtgcgacaa tgagcgcagc t                                               1161


<210>  66
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  66
atgctgaaaa tagcggtgcc taataagggt tctttatcag aaagagcaat ggaaatacta       60

gctgaagctg gttacgccgg taggggtgat tctaaatcct tgaacgtgtt cgacgaagca      120

aataatgtag agtttttctt cttgaggccc aaagatattg ctatatatgt tgccggtggt      180

caattagatt taggtattac aggcagagat ttagctaggg attcccaggc agacgtgcat      240

gaagtcttat ctttaggatt cggtagttct acattcaggt acgcagctcc tgcagatgaa      300

gaatggagca ttgaaaaact agatgggaag agaatcgcaa catcctatcc taacctagtt      360

agagatgact tggccgcacg tggtctatca gccgaagttt tgcgtttaga tggtgcagtt      420

gaagtatcta ttaaattagg cgtggctgat gctattgcag atgtagtctc aacaggtcgt      480

acattaagac aacaaggatt ggctcccttc ggggaagttt tgtgtacctc agaagcagtc      540

attgttggca ggaaagatga aaaagttaca ccggaacagc aaattttatt aagaagaatt      600

cagggcatac tacatgcgca aaatttttta atgctagatt ataaggtgga tagagacaac      660

ttggatgcag ctaccgcagt aacacctggt ttttcaggcc cagcagtttc tcctctggcc      720

agagacaatt gggtcgctgt tagagcaatg gtgcctcgta ggagcgcgaa tgccataatg      780

gataagctag ctggtttagg agcagaagcc attttggctt ctgagatcag aatcgcaagg      840

att                                                                    843


<210>  67
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  67
atgagccttt cccctttgga tcaaaatcgc attgagtctt tttggcaata ctgtttacag       60

caccaatact tcaaccttgc gtatccggag tccgcagatt ttgattatgc accgcttcac      120

cggtttctgc gtttttctat aaacaactgc ggggactgga atgaatcgtc taactatttg      180

ctcaattcat ttgacttcga acgtgaagtc atgcatttct tcgcagagct ttttcatatt      240

cctttcgacg agagttgggg gtacgtaacg aatggcggaa ccgaaggaaa catgtttgga      300

tgctaccttg cacgggaatt gtttcctgac gctacattat attacagcaa agatagccat      360

tatagcgtcg ctaaaatcat caaattgctt agaataaaaa gcagagcggt tgatagcctt      420

ccgtccggcg agatagatta cgatgatctt gtagccaaaa ttcagcaaga ccaagaacgg      480

catccaattg tttttgtaaa cgtcggaaca accatgaaag gtgccgtcga cgatattggt      540

gtcattcaac ataagctggc agaggcagga attccgcgtc aagattatta tctgcatgct      600

gacgcagcat tatcaggcat gatactgccg tttgtggacg ctccgcagcc gtactcattt      660

gctgacggta tcgattccat ttccgtctct ggccacaaaa tgattgggag cccgatgcca      720

tgtggtatag tactcgccaa acgctcaaac gtgagcagaa tttccgtcga aattgactat      780

atcagcgcga aggatcagac aattagtggt tctagaaatg gtcatacgcc gatgatgttg      840

tgggcagcga tcaaatccag acctttggct gaatggcgaa gaaaagtgcg tcattgtctg      900

gatatggctc aatatgctat agaccggctg caagctgcag gcatccaggc ctggcggtgt      960

aaaaactcaa ttactgtagt ctttccttcg ccgtccgaac cagtatgtga caaacatggg     1020

ttagccagat ctggcggcac ggcgcatctg attacaacgc ctcatcatca cgattcacaa     1080

cggttagatc ggcttttaga tgatatcgtg caggacctgg gtgcaatgac ggcaccggcg     1140

ggagccacaa tgagtgcagc c                                               1161


<210>  68
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  68
atgttaaaaa tagcagtacc taataaagga tctttgagcg aaagagctat ggaaatcttg       60

gcagaagccg gctatgcagg tcgtggcgat agcaaaagcc tgaatgtatt tgatgaagct      120

aataacgtcg agtttttctt tttgcggcca aaagatattg ctatttatgt ggcaggtggg      180

caactggacc ttggcatcac cggcagagac cttgctagag atagtcaggc cgatgtgcac      240

gaagtattaa gcttaggctt cggatcctct acttttcgct atgcggcccc tgctgatgaa      300

gaatggtcca ttgagaagct tgatggaaag cggatcgcga catcttatcc gaatcttgta      360

cgggatgatt tggcagctcg cggattgtct gcagaagtct taagacttga tggagcggtc      420

gaagtgtcta tcaagcttgg ggttgcggac gctattgcgg atgtagtctc tacaggccgt      480

acattgcgtc aacaagggct cgccccattc ggcgaagtgc tttgcacatc cgaagccgtg      540

atcgtaggca gaaaagatga aaaagttact ccggaacagc aaatactgtt gcgaagaatt      600

caagggatcc tgcatgctca gaatttttta atgttagact ataaagtcga tcgcgataac      660

ttagatgcgg caacggccgt tacgccgggg ttttcaggtc ctgctgtttc gccacttgct      720

cgcgataact gggttgcggt aagagctatg gttccgcgca gatcagctaa tgcaatcatg      780

gataagctgg ctggacttgg cgctgaagcc attctcgctt cagagattcg tattgcccgc      840

atc                                                                    843


<210>  69
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  69
atgtccgaat tggacgccaa acttaacaaa cttggggttg atagaattgc gatttccccg       60

tacaaacaat ggacgagagg atacatggaa ccggggaata tcggaaacgg ctacgttaca      120

ggacttaaag ttgatgcagg agttcgcgac aaaagtgacg atgacgttct tgatggaatc      180

gtcagttacg accgcgctga aacaaaaaac gcttatattg gacaaatcaa tatgacaaca      240

gcgagttctt ttacgggcgt gcaaggacgc gtaataggat atgatatctt gcgcagtcct      300

gaggtagaca aagcaaaacc gctgtttacg gaaacgcagt gggacggctc agagcttcct      360

atttatgatg caaaaccttt gcaagatgct ttggttgagt attttgggac agaacaagat      420

agaagacatt atcctgctcc gggatccttc atcgtgtgtg ccaataaagg agtgacagca      480

gaaagaccaa aaaatgatgc tgacatgaaa ccaggccagg ggtatggagt ttggtctgca      540

attgctatct cttttgccaa agatccgact aaagattctt cgatgtttgt agaggatgca      600

ggagtgtggg agacaccgaa tgaggatgag cttctggagt acctggaggg tagacgtaaa      660

gcgatggcta aatcaattgc ggaatgcggc caagatgcac atgctagctt tgaaagcagc      720

tggatcggtt ttgcatacac gatgatggaa ccgggccaga taggtaacgc gattactgtc      780

gcaccttatg tctcactgcc gatcgatagc atcccgggag gatcaatctt gaccccggac      840

aaagacatgg agattatgga gaatttaaca atgccggaat ggttagaaaa gatgggatat      900

aagtccctca gcgcgaataa cgccttgaag tat                                   933


<210>  70
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  70
atgtctgaac ttgatgcaaa actaaacaaa cttggggtcg atagaatcgc tatatctcca       60

tacaagcaat ggacccgtgg ttatatggaa cccggaaata taggtaatgg atatgtaact      120

gggctgaagg ttgatgccgg tgtaagagac aaaagcgatg acgacgtgct ggacggtata      180

gtctcttatg atagggccga gactaagaac gcttacatcg gccagattaa tatgactact      240

gcatcttctt ttacaggtgt gcaaggacgt gtaataggat acgatattct aagaagccca      300

gaagttgaca aggcaaaacc gctattcaca gaaactcaat gggacggctc tgaactaccg      360

atctacgatg ctaaacctct acaagatgct ttagttgaat acttcggtac ggagcaagat      420

aggcgtcact acccagcccc aggtagtttc attgtttgtg ctaataaggg tgttacagca      480

gaacgtccaa aaaacgatgc cgatatgaaa cctggtcaag gatatggggt ctggtctgcg      540

attgctattt ctttcgctaa ggacccaact aaagattctt ccatgttcgt tgaggacgca      600

ggcgtatggg agactccgaa tgaagatgaa ttgcttgaat acctagaagg taggcgtaag      660

gctatggcta agtcaatagc tgaatgtggt caagacgcgc atgcaagttt cgaatccagc      720

tggataggtt ttgcttacac aatgatggaa cccggtcaaa tcgggaacgc cattacggtc      780

gccccttacg taagtttgcc tattgacagt ataccaggag gttctattct tactcccgat      840

aaagatatgg aaattatgga aaacttaact atgccggagt ggttggaaaa gatggggtat      900

aaatctctgt ccgctaataa tgctttgaag tac                                   933


<210>  71
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  71
atgagcgaat tggacgcaaa actcaacaaa ctgggtgtgg atcgcatcgc aatcagccca       60

tacaagcagt ggacccgcgg ttatatggaa cccggtaaca tcggcaatgg ctacgtcact      120

ggacttaaag ttgacgcagg tgttcgtgat aaaagcgacg acgatgtgct ggatggaatc      180

gttagctatg accgagcaga gaccaaaaat gcatatatcg gacagatcaa tatgactacc      240

gctagctcct ttaccggagt gcagggacgt gtgattggct acgatatcct ccgctcgcct      300

gaggttgata aagccaaacc actcttcacc gaaacccagt gggatggctc cgaactgcca      360

atctacgatg cgaagcctct gcaggacgcc ctcgtcgaat attttggaac cgagcaggat      420

cgccgtcact atcccgcacc gggttccttc attgtgtgtg caaacaaagg cgtcaccgct      480

gagcgcccta aaaacgatgc agacatgaaa ccgggtcaag gatatggcgt ttggtccgcg      540

atcgccatct cgtttgccaa agacccaacc aaggactcat ccatgtttgt cgaggacgcc      600

ggagtgtggg agaccccaaa cgaggacgag ctcctggaat acctcgaggg ccgccgcaaa      660

gcgatggcaa agtcaattgc ggaatgcggt caggatgcgc acgcgtcttt tgaatcttcc      720

tggatcggat tcgcatacac gatgatggaa cccggtcaaa tcggcaacgc gatcactgtc      780

gccccttacg tctcactccc gattgacagc atcccgggtg gatcaatcct gaccccagac      840

aaggatatgg aaatcatgga gaatttgacg atgcccgagt ggttggaaaa gatgggctac      900

aagagcctgt ccgcgaacaa cgcgttgaag tat                                   933


<210>  72
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  72
atgattctgt cacctgctga ccaagaacgt atcgaaacat tctggaatta ctgcttgaag       60

caccagtact tcaacattgg ttatcctgag tcggctgact tcgattactc cgccttgttt      120

cgtttcttca aattcagcat caacaattgt ggcgattgga aggattactc caactacgcg      180

ctgaactcgt tcgatttcga aaaggatgtc atggcctatt ttgctgagat tttccaaatc      240

ccgttcgagg aatcgtgggg ttacgtcacg aatggtggta ccgagggcaa tatgtttggc      300

tgttacctcg ctcgcgaact gttctccgat tccaccctgt actactccaa agatactcat      360

tattccgttg gcaagatcgc aaaactgttg cagatgaagt cctgcgtcat cgagtctctg      420

gataacggcg aaattgatta cgatgacctg attcataaga tcaaaaccaa taaggagtcc      480

cacccaatca ttttcgcgaa tattggtacg accatgaccg gtgctattga tgacattgag      540

atgatccaag aacgcctggc acagattgga atcatgcgac gcgattatta tattcatgca      600

gacgcggcgt tgtcaggcat gatcctccct tttgtggatc acccccaggc ctttagcttt      660

gcacatggca ttgactccat ctgcgtgtcg ggccacaaaa tgatcggctc accaatcccg      720

tgtggtatcg tggtcgcaaa acgccaaaat gttgagcgca tttcagttga tgtagattac      780

atctccaccc gagatcaaac tatctccggc tcccgaaacg gtcacactgt gcttctgatg      840

tgggcagcga tccgctcaca aaccaatctg cagcgccgtc agcgtatcca gcactgcctt      900

aaaatggctc agtacgctgt agaccgcttc caggctgtgg gtatcccagc atggcgcaac      960

ccaaactcca tcaccgtcgt cttcccatgc ccgagcgaac atatctggaa gaagcactac     1020

cttgccactt ccggtaacat ggctcatctg attactaccg cgcaccatcg agatacccgt     1080

caaatcgact ccctgattga cgatgttatt ttcgacttgc aaggcgcgtc aaaacgcacg     1140

gtcggcttc                                                             1149


<210>  73
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  73
atggatctgg ttaaccactt gaccgatcgt ttgctctttg ccatcccgaa gaagggtcgc       60

ctctactcga agtcggtgtc cattctcaac ggcgccgata tcactttcca ccgctcccaa      120

cgactcgaca ttgcactgtc tacttctctg ccagtcgcac ttatcttctt gccagctgct      180

gacatcccaa cctttgttgg tgaaggtaaa tgtgacctgg gtatcactgg agttgatcag      240

gtgcgcgaga gcgacgtcga cgtcgatctt gcgatcgatc ttcaattcgg caactgcaag      300

cttcaggtac aagtcccggt caatggcgag tacaagaaac cagagcaact catcggcaag      360

accattgtca cttccttcgt taagcttgct gaaaagtatt tcgctgacct ggaaggaacc      420

acagtggaga aaatgaccac acgtattaag ttcgtttcgg gctcggttga ggcgtcctgc      480

gctttgggca ttggcgatgc aatcgttgat ttggtagagt ccggcgagac catgcgtgct      540

gcaggtctgg tcgatatcgc tactgttctg tccactagcg cttatttgat tgaaagcaag      600

aacccaaaga gcgacaagag cctgatcgca actatcaagt ctcgtatcga gggcgtgatg      660

acggcccagc gcttcgtgtc atgcatctac aacgcgcccg aagacaagct gcctgagctc      720

ttgaaagtga ccccaggccg tcgtgcgcct acaatttcca aaatcgacga cgagggttgg      780

gttgcagtgt cgtcaatgat cgaacgcaaa acaaagggtg tggtactgga tgaacttaag      840

cgcctcggag cctcagatat tatggtcttc gaaatcagca actgccgtgt t               891


<210>  74
<211>  404
<212>  PRT
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  74

Met Thr Leu Ser Pro Ala Asp Gln Arg Lys Leu Glu Gly Phe Trp Gln 
1               5                   10                  15      


His Cys Val Thr His Gln Tyr Phe Asn Ile Gly Tyr Pro Glu Ser Ala 
            20                  25                  30          


Asp Phe Asp Tyr Ser Gln Leu His Arg Phe Leu Gln Phe Ser Ile Asn 
        35                  40                  45              


Asn Cys Gly Asp Trp Asn Glu Tyr Ser Asn Tyr Leu Leu Asn Ser Phe 
    50                  55                  60                  


Asp Phe Glu Lys Asp Val Met Thr Tyr Phe Ala Glu Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Leu Glu Asp Ser Trp Gly Tyr Val Thr Asn Gly Gly Thr Glu Gly 
                85                  90                  95      


Asn Met Phe Gly Cys Tyr Leu Gly Arg Glu Leu Phe Pro Asp Gly Thr 
            100                 105                 110         


Leu Tyr Tyr Ser Lys Asp Thr His Tyr Ser Val Ala Lys Ile Val Lys 
        115                 120                 125             


Leu Leu Arg Ile Lys Cys Arg Ala Val Glu Ser Leu Pro Asn Gly Glu 
    130                 135                 140                 


Ile Asp Tyr Asp Asp Leu Met Ala Lys Ile Thr Ala Asp Gln Glu Arg 
145                 150                 155                 160 


His Pro Ile Ile Phe Ala Asn Ile Gly Thr Thr Met Arg Gly Ala Val 
                165                 170                 175     


Asp Asn Ile Val Thr Ile Gln Gln Arg Leu Gln Gln Ala Gly Ile Ala 
            180                 185                 190         


Arg His Asp Tyr Tyr Leu His Ala Asp Ala Ala Leu Ser Gly Met Ile 
        195                 200                 205             


Leu Pro Phe Val Asp His Pro Gln Pro Phe Ser Phe Ala Asp Gly Ile 
    210                 215                 220                 


Asp Ser Ile Cys Val Ser Gly His Lys Met Ile Gly Ser Pro Ile Pro 
225                 230                 235                 240 


Cys Gly Ile Val Val Ala Lys Arg Asn Asn Val Ala Arg Ile Ser Val 
                245                 250                 255     


Glu Val Asp Tyr Ile Arg Ala His Asp Lys Thr Ile Ser Gly Ser Arg 
            260                 265                 270         


Asn Gly His Thr Pro Leu Met Met Trp Ala Ala Leu Arg Ser Tyr Ser 
        275                 280                 285             


Trp Ala Glu Trp Arg His Arg Ile Lys His Ser Leu Asp Thr Ala Gln 
    290                 295                 300                 


Tyr Ala Val Asp Arg Phe Gln Ala Ser Gly Ile Asp Ala Trp Arg Asn 
305                 310                 315                 320 


Glu Asn Ser Ile Thr Val Val Phe Pro Cys Pro Ser Glu Arg Ile Ala 
                325                 330                 335     


Thr Lys Tyr Cys Leu Ala Thr Ser Gly Asn Ser Ala His Leu Ile Thr 
            340                 345                 350         


Thr Pro His His His Asp Cys Ser Met Ile Asp Ala Leu Ile Asp Glu 
        355                 360                 365             


Val Val Ala Glu Ala Gln Leu Asn Thr Leu Arg Ser Lys Arg Ala Phe 
    370                 375                 380                 


Thr Asp Gln Thr Val Val Glu Arg Leu Pro Ala Ala Ser Phe Asn Leu 
385                 390                 395                 400 


Arg Thr His Tyr 
                


<210>  75
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  75
atgcagaaat atgaatacga tcctaagtgg gtaatcaata atgcgatttc aagcgagcgt       60

gagttttgca ccggctacca aaaccccggc gcgtctggaa atggctatgt cacgactatt      120

aagctttcta cgggtctcgt ggacattacc ccttgggaaa aagtccaggc catgagcgag      180

catgaggtta ttaagttcga tcgcggttgc tctaatattg ttagctatga tcgttgtgaa      240

tgtaatgacg cctatattgg cgcaatcaac atgttgactg cctcctcctt ctctggtctg      300

caaggcgtca tttggggtta cgatatcgct gtagtggaga acctgcggag ccggaagctt      360

tacgatcaaa agtggccgag cggcgacccg aattcggaat attccacgcc ggtttattct      420

attgagccgc tgctcaacgc aacggagcgc cttttcggcc atgcggagcc tggcaagcgt      480

cgctttaatc ccatccccgg atccatggtg gtctgtgcaa ataaatctgc cacttcagac      540

cctagctcag atgtaaaaga gggctgggct ttttctgtca tctcccttgc aattcttgag      600

aaccggaata gcggatcaaa tctcttcatt gaagactgcg acattattga tatcaataat      660

ccagacggta cccgtaagac taaagaggat gtcaaagcga tgctcgacac gacccttcgc      720

aaggtcacgg aatgcacggt attgtgtggt ctcgaccaac acatcaagta caaagagatt      780

ttcatcggat acaaggtgat taagttcaac gagaagcaag taggttgtgc gctcgcgtgt      840

gcaccgtacg tgacgcttgc acggaatgca gtgcctcagg gaatgaaacc gtcgaaactg      900

acggacatga acatttctca atgggagaac gctctgaatc tgcaacccct ggagaagatt      960

gaaaaatcaa agatcggcat tttgggaatg ggtgtgcttg ac                        1002


<210>  76
<211>  1047
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  76
atgactctgc actcacggta ttctaaattg aaaggtgaga acaaaatgca aaagtacgag       60

tacgacccaa agtgggttat caacaacgca atctcgtccg aacgggaatt ttgtaccggc      120

tatcagaacc caggtgctag cggcaacggc tatgttacta ctattaaact gtcaacgggc      180

ttggtagata ttacgccatg ggagaaggtg caggcaatgt ccgagcacga agtgattaag      240

ttcgaccggg gatgcagcaa cattgtctct tacgaccggt gtgaatgtaa tgatgcttac      300

attggagcca ttaacatgct gactgcttct tctttctcgg gactgcaggg agtcatctgg      360

ggttatgata tcgcagtcgt ggaaaatctg cgttcgcgga agctctacga tcaaaaatgg      420

ccttccggcg atccaaattc ggaatattct acgcctgtgt attcgattga gccgttgttg      480

aatgccactg aacggctctt cggtcacgcg gagccaggaa agcgccgttt taacccaatc      540

cctggatcaa tggtggtgtg tgcgaacaag tcagctacct cggatccgtc ttcggacgtt      600

aaggagggat gggcattttc agttattagc ctcgctatcc ttgagaatcg caactctggt      660

agcaatctgt ttatcgaaga ctgtgatatt atcgacatta acaatcccga tggtactcgc      720

aaaaccaaag aggatgtgaa ggctatgttg gataccactt tgcgcaaagt tacggagtgt      780

acggttctct gcggtcttga ccagcatatt aagtataaag aaatcttcat tggctataaa      840

gtcattaaat tcaacgagaa gcaagtggga tgcgctcttg cctgcgcgcc ctatgttact      900

ctcgcacgta atgctgtacc gcaaggaatg aaaccgtcca agctcactga tatgaacatt      960

tcacagtggg aaaatgcact gaacttgcag ccactggaaa agattgaaaa gtcgaaaatc     1020

ggcattcttg gaatgggagt gctcgat                                         1047


<210>  77
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  77
atgagcgaac tcgacgcaaa actgaataaa ctcggagtag accggatcgc gatttccccg       60

tataagcaat ggacgcgggg atacatggag ccaggtaaca tcggaaatgg ttacgtgacg      120

ggacttaagg tagatgctgg tgtacgcgat aaatccgatg atgatgtatt ggacggtatt      180

gtcagctatg accgggcgga gacgaaaaac gcctacatcg gccaaatcaa catgaccact      240

gcatcgtcat ttactggcgt ccagggccgg gtgattggat acgacatcct tcgctcccct      300

gaggtagaca aggcgaagcc gctgttcacg gagacgcaat gggatggttc agaacttccg      360

atttatgacg cgaaaccgct tcaagacgct cttgtagagt attttggcac cgagcaagat      420

cgtcgccatt acccagcacc aggatccttc attgtttgtg ctaataaggg tgtaaccgca      480

gagcggccta agaacgacgc agacatgaag cctggccagg gctacggcgt atggtcagcg      540

attgccatta gctttgcaaa ggatcccacc aaagattctt caatgtttgt agaagatgca      600

ggagtctggg agactccgaa cgaagatgag ctcctggaat accttgaggg acggcgtaag      660

gcgatggcaa agtctatcgc ggagtgtggt caggacgcac atgcgtcctt tgaatcgtcg      720

tggattggct tcgcgtatac gatgatggag cccggccaaa tcggcaacgc tattactgtg      780

gccccctatg tttctttgcc cattgacagc atcccgggag gaagcatcct taccccggat      840

aaagatatgg aaattatgga gaacctcacg atgcccgaat ggctggagaa aatgggatac      900

aagtctctca gcgctaacaa cgcacttaaa tat                                   933


<210>  78
<211>  1149
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  78
atgattttgt ctccagccga ccaggaacgt atcgagactt tctggaatta ttgcctgaaa       60

catcagtact ttaacatcgg ctaccccgaa tcagccgact ttgactactc tgcactgttc      120

cgtttcttta agttttccat taacaactgc ggagactgga aggactattc aaactatgcc      180

cttaacagct tcgacttcga gaaagacgtc atggcgtact ttgctgagat ttttcaaatc      240

ccctttgaag agtcttgggg atacgtgact aatggcggca ctgagggcaa tatgtttggt      300

tgctacctcg cccgtgagtt gttctccgat tctacgcttt attattcgaa ggacacgcat      360

tatagcgtcg gcaaaatcgc caagctgctc caaatgaaat cctgcgttat cgagtccctc      420

gacaatggcg aaatcgacta tgacgacttg attcataaaa ttaaaacgaa taaggagtcc      480

cacccgatta ttttcgctaa tatcggtacc actatgacgg gtgcaattga tgatattgaa      540

atgattcaag aacgtctggc tcagatcggc attatgcggc gggactacta tattcacgcg      600

gacgcagctc tttctggcat gatccttccc ttcgtcgatc atccacaagc gttttccttc      660

gcacatggca tcgattcaat ttgtgtttcg ggccataaga tgattggaag cccaattcca      720

tgtggcattg tcgtagctaa acgccaaaac gtggaacgta tctcagtaga tgtggattat      780

atcagcactc gtgaccaaac catctcgggt tcccggaatg gacacaccgt gttgctcatg      840

tgggcggcaa tccggtcgca gaccaatttg caacgtcggc agcggatcca acattgcctg      900

aagatggctc agtacgcagt cgatcggttt caagcagtag gtattcctgc atggcggaac      960

ccgaatagca tcacggttgt gttcccatgt ccttctgaac acatctggaa aaaacactat     1020

ctcgcgactt cgggcaatat ggctcatctc atcactaccg ctcatcatcg cgatactcgt     1080

cagattgatt cgctgatcga cgacgtgatc tttgatttgc agggtgcgtc caaacggacc     1140

gtgggattt                                                             1149


<210>  79
<211>  2541
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  79
atggatttca aggagtaccg ccagcgcgga aaggagatgg tcgattatat tgccgactac       60

cttgagaata ttcgcgagcg gcgcgtcttc cccgatgtaa gcccgggcta tatgcgtcag      120

ctcttgcccg aatcagcgcc gatcgaagga gagccgtggc cgaagatctt cagcgatgta      180

gagcgcattg taatgccagg aatcacgcac tggcagtccc cgcatatgca tgcctatttc      240

ccagccttga attcaatgcc ctccctcctc ggagatatgt tggccgatgc gattaactgt      300

ctgggcttca cctgggcatc aagccccgca tgcactgagt tggagatcat cgtcatgaat      360

tggttgggca agatgattgg cctgcccgac gcattcctgc acctgtcgtc ccaatcacaa      420

ggtggtggcg tcctccagac tactgctagc gaggccactt tggtgtgcct gctggcagga      480

cggactcgtg caatccaacg tttccatgag cggcatcctg gttaccaaga cgcggaaatt      540

aacgcgcggc ttgttgctta ttgctccgac caagcacatt cgtcggtgga gaaggcagct      600

ttgatcggac ttgtccgtat gcgctatatc gaggctgacg atgacttggc catgcgtggt      660

aagctgctgc gggaggcgat tgaggacgat attaaacaag gattggtgcc attctgggtc      720

tgcgctactc ttggcaccac cggttcttgt agctttgaca atttggagga aattggaatt      780

gtttgcgctg agcaccactt gtggcttcac gtagatgcgg catacgcggg tagcgctttc      840

atttgccctg agtttcggac gtggttgcgg ggcatcgaac gtgccgactc gattgctttc      900

aacccctcga aatggctgat ggtccacttt gacgccactg ctctttgggt gcgggatagc      960

accgcggtcc atcgcacttt caacgtcgaa cccctctacc tccaacatga aaactcaggt     1020

gttgctgttg atttcatgca ttggcaaatc cccctgtcgc ggcggtttcg tgctttgaaa     1080

gtgtggttcg tattgcgctc ttacggtatt aaaggactgc aacggcatat ccgcgaaggt     1140

gttcgcctgg cgcagaaatt tgaagccctc gtcctggccg atcaccgttt cgagctgcca     1200

gcaaaacgcc accttggcct ggtggtattc cgtatccgcg gcgacaatga gatcactgaa     1260

aaattgctta agcgtcttaa ccaccgtggc aacctccact gcatcccatc gtccctcaag     1320

ggtcaatatg ttattcgctt caccatcacc tcaacccaca cgacgctcga tgatattgta     1380

aaggattgga tggagatccg ccaggtagcg tccacggtac tggaggaaat gaatattact     1440

atttcgaatc gtgtttacct gaaggaaacg aaagagaaga acgaagcctt cggatcgtct     1500

ctgctgctct ctaactcacc tctgtctccg aaagtggtca acggttcctt cgcagcaatc     1560

ttcgacgcgg acgaattcct cgctaaaacg tatgccggcg tgcgtattgc tcatcaggag     1620

tcaccctcca tgcgccgtcg tgtgcgcggc attctgatga gcggcaagca gttctccctg     1680

gattcccaca tggacgtcgt ggtgcaaacg acgctcgacg ctggaaacgg agcaacgcgt     1740

acttctacta ctaactcgta tggtcacacc acttccgccg cacaggccaa ttcagagcgg     1800

caggcttcta tccaggaaga taacgaggaa agcccagagg agactgaact tttgtcgctt     1860

tgccgtacct caaacgttcc cagccccgaa catgcacact ccttgtctac gccatcccgc     1920

tcatgctcgt ccagctctca ttcgttgatc cattcactta cccagtcgtc tccgcggtca     1980

agcccggtta atcagtttcg gcctattacc ctctgcgccg taccctccca atcccagctg     2040

tccatgccgc ttgcaatgcc tttgccgaac cgcaacgtca ctgtttcggt agattcactg     2100

ctcaacccag ttacgacttg caatgtgtac cacggcaaac gttttctcga acccctcgag     2160

aacttggccc aaacctctgc atctttctcc tcttctattt tccggctgcc cacccccatt     2220

gccactccca ctcgggagag cccggaggat cccgactggc cagcgaagac tttctctcaa     2280

ctcttgttgg aacggtatag cagccaaagc caatcgctgg gaaataattc ctctacggaa     2340

tcaagcagct tgtccggcgg tgccaccccg acgccgacgc caatgtcgtc acttgacgaa     2400

ctcgtaacgc ctcttctgtt gtctttcgct tccccaagcc agcccatgct ctcggcacat     2460

ggtatcggtg aaggacaacg cgagcaggga tcggactcag acgcgacggt ttgctccacg     2520

acttcctcta tggaatcact g                                               2541


<210>  80
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  80
atgtccctgt cccctttgga tcaaaatcgc attgagtcct tctggcaata ttgtttgcag       60

catcagtact tcaatctggc ttatcccgaa tctgcggatt tcgactacgc ccccttgcat      120

cgtttcctcc ggttctctat caacaactgc ggagattgga acgagtcctc aaattacctg      180

cttaactcgt ttgatttcga gcgggaggta atgcacttct tcgcggaatt gtttcatatt      240

ccctttgatg agtcttgggg ttatgttact aatggaggta ctgaaggcaa tatgtttggc      300

tgctaccttg ctcgcgagtt gttccctgat gcaaccttgt attactcaaa agatagccat      360

tactccgtcg ctaagattat caaattgttg cggatcaaat cgcgcgctgt ggacagcctc      420

cctagcggtg aaatcgatta tgacgatctt gtggcaaaga ttcaacagga tcaggaacgt      480

cacccaatcg tttttgttaa cgtgggtacg actatgaaag gcgctgtgga cgatattgga      540

gttattcagc acaaacttgc tgaagcaggt atcccccggc aagattacta cttgcatgcg      600

gatgcggcac tttccggcat gatcctcccg tttgtggatg caccccaacc ctattccttt      660

gctgatggaa ttgacagcat ctccgtatct ggacataaga tgattggaag cccgatgcct      720

tgtggcattg ttttggcaaa acggtccaat gtctctcgga ttagcgtaga gatcgattac      780

atctccgcaa aggaccagac gatctctgga tcccgtaatg gtcacacccc tatgatgctc      840

tgggctgcaa tcaaatcacg gccgcttgcg gaatggcgtc ggaaggttcg ccattgtttg      900

gatatggctc agtacgcgat tgatcgtctc caagctgcag gtattcaagc gtggcgctgc      960

aagaacagca ttacggttgt atttccttcg ccctcagagc ctgtgtgcga caagcatggc     1020

ttggcccgct ctggcggtac cgcgcacctc attaccactc cgcatcacca tgactcccaa     1080

cgcttggacc gtctcttgga cgacatcgtc caagacttgg gcgcaatgac ggctcctgct     1140

ggtgcaacta tgtctgccgc a                                               1161


<210>  81
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  81
atgttggaca atacgcgcct ccgcatcgcc atccaaaaaa gcggccgtct gtcagacgac       60

tcgcgtgaac tgctcgcccg gtgcggtatc aagattaacc ttcacaccca acgtctgatt      120

gcaatggcgg aaaacatgcc tattgacatt ttgcgtgtcc gggacgatga cattcctggc      180

ctggtaatgg acggcgtcgt tgatctggga attattggtg agaatgtgct tgaggaggag      240

ctcctgaacc ggcgcgcgca gggtgaggac cctcgctacc tgactctgcg ccgcctggat      300

tttggcggat gtcggctgtc gcttgcaacg cccgtggatg aagcctggga tggacctgct      360

gcgctggacg gcaagcgtat tgctacctca tatcctcatc ttttgaagcg ttatttggat      420

caaaaaggtg tatccttcaa gagctgcctt cttaacggtt cagtggaggt cgccccgcgc      480

gccggtcttg ctgatgctat ttgtgacctc gtttcgacgg gtgccaccct tgaggcgaac      540

ggtctgcgcg aagtggaagt aatttatcgc tcgaaagcgt gtcttatcca gcgggacgga      600

gagatggcgc agtccaaact tatcgataaa ctgcttactc gtattcaggg tgtgatccaa      660

gcccgggaaa gcaagtatat catgatgcac gccccgtcgg aacgcctgga agaagtcatt      720

gcgcttcttc cgggagctga acgtccaacc atcctgccgc tggcaggcga acaacaacgt      780

gttgctatgc acatggtttc aagcgaaact ctgttctggg agacgatgga aaagcttaag      840

gctcttggcg cgtccagcat tttggtgttg ccgattgaaa aaatgatgga a               891


<210>  82
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  82
atgtccgagt tagacgcaaa gctaaataaa ctgggtgtcg acagaatcgc aatttctcca       60

tataagcaat ggacgagagg gtatatggag ccagggaata tcgggaacgg ctacgtcact      120

ggacttaaag tagacgccgg ggttagagac aaaagcgatg atgacgtcct agatggaata      180

gtatcctacg atagagctga aaccaagaac gcatacattg ggcagataaa tatgacgact      240

gctagctctt ttacgggtgt acagggtagg gttattggat acgacatctt gagatccccg      300

gaagtcgata aggccaaacc gttatttaca gaaacgcagt gggatgggtc agagctaccg      360

atatatgacg caaaaccatt gcaagatgcg ttagtggagt acttcgggac cgaacaagat      420

agaagacact accctgctcc cggttcattc atagtatgcg ccaataaagg cgtaacagcc      480

gaaaggccga aaaacgatgc ggacatgaaa ccaggtcaag gttacggtgt gtggtctgct      540

atagcgatta gttttgcgaa agatcctacc aaagatagca gcatgttcgt cgaagacgct      600

ggtgtgtggg agacccctaa cgaggacgaa ttacttgagt atttggaagg cagaagaaaa      660

gcgatggcta agtcaattgc tgaatgcggg caggacgcac acgcgtcctt tgaaagcagc      720

tggataggct ttgcatatac aatgatggag ccaggtcaaa taggtaacgc gatcaccgta      780

gcaccttacg tgtcccttcc tatcgattcc atccctggag gtagcatttt gacgcctgac      840

aaggatatgg agatcatgga gaaccttaca atgcctgagt ggctagagaa gatggggtac      900

aaatccctat ccgcgaacaa cgcgctaaag tac                                   933


<210>  83
<211>  1239
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  83
atggaatcag acattaagaa cgagacctct ttccaagagc ttgatatgat cctgacacag       60

tacctggaaa cactatcaga aagaaaaaag tatcatatag gctaccccat aaacatgtgt      120

tacgagcatc atgcgaccct ggcacccttg cttcagtttc acctgaataa ctgcggtgat      180

ccgttcacac aacaccccac tgactttcac agcaaggact ttgaggttgc ggtgcttgac      240

tggttcgccc aactgtggga gatagagaag gacgagtact ggggttatat aacttccgga      300

ggaactgaag ggaatctgca tggtttttgg ttaggtagaa gagagttgtt gccaaatggt      360

tacctatatg ccagcaaaga ttcccattac tccatattta aagccgctag aatgtacaga      420

atggagttac aaactatcaa tacgctagtt aatggagaga ttgattacga agacttgcag      480

agtaaactgc ttgtcaacaa gaacaagccc gcgataatta atatcaatat tgggacaact      540

tttaaaggtg ctatagatga cttggatttc gttatacaga cattagaaaa ctgcggctat      600

tctaatgata actattacat tcactgcgac agggctctat gtggactaat tcttccattt      660

atcaaacacg cgaagaagat cacgttcaag aagcccattg ggagcatcag catttctggg      720

cacaagttct taggttgccc gatgagctgc ggcgtgcaaa taacacgtag gtcatatgta      780

agtacactga gcaaaatcga gtacattaac tccgcggacg caaccattag tggcagccgt      840

aacggattca cgccgatctt tctgtggtat tgtctatcta agaaaggaca tgcgagatta      900

caacaagatt ctattacctg tattgagaat gcgagatacc taaaggatag gctgctggaa      960

gccgggatta gcgtaatgct gaatgatttt agcatcacag tagtattcga acgtccctgt     1020

gatcataaat ttattagaag atggaacctg tgctgtctgc gtggcatggc tcacgtagtc     1080

atcatgccgg ggataactcg tgagacgatt gatagttttt tcaaggatct gatgcaggag     1140

cgtaattata aatggtacca ggacgtgaaa gccctaccac cttgtttggc agatgactta     1200

gcattgaact gcatgtgtag caataagaaa atgcataac                            1239


<210>  84
<211>  1986
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  84
atgatggagc cgtgtgaata cagggagtac agggagtatt acagagcgag gggtaaagag       60

atggttgatt atatcagcca gtatttaagt acagtcaggg agagacaggt cacccctaat      120

gtacagcccg ggtatctacg tgcgcagttg ccagcatccg caccagaaga gcctgattct      180

tgggattcta tctttgggga tatagagaga gtcattatgc ctggggtcgt ccattggcaa      240

tctccgcaca tgcatgctta ctatcccgcg ctgactagtt ggccgtccct acttggagat      300

atgttagctg atgcgattaa ctgtcttggc ttcacctggg ccagctcacc cgcttgcact      360

gaactggaaa tgaatattat ggactggtta gcgaagatgt tagggcttcc ggaatatttt      420

cttcaccatc acccatcatc cagaggagga ggggtcttac aatccacagt ctctgagtcc      480

acgctgatag cacttttagc ggctcgtaaa aataaaatct tagccatgaa ggcttgcgaa      540

cccgatgcaa atgagagttc actaaacgca aggctggtag cgtatacctc agatcaagcg      600

cattcctcag ttgaaaaggc cgggcttatt agcttggtta agatcaggtt cctaccggtt      660

gatgataatt ttagtctaag gggggaagcg ctgcaaaagg ctatcgaaga agataagcag      720

cagggacttg tacctgtctt cgtgtgcgcg actcttggaa ctacgggtgt ttgtgcattc      780

gatcgtctga gcgaactagg accaatctgc gcctccgagg ggttgtggct acacgtagat      840

gccgcctatg ctggcactgc tttcttatgc ccagagctga gagggtttct agagggtatc      900

gagtacgctg attcattcac ttttaatcca tccaagtgga tgatggtcca cttcgattgt      960

acaggcttct gggtaaagga caaatataag ttgcagcaaa cgttctctgt aaacccgatt     1020

tatcttaggc atgctaattc cggggcagcc accgacttca tgcactggca gatccccctt     1080

tctcgtaggt ttagaagcat aaagttatgg ttcgtaatca gatctttcgg tgtaaagaat     1140

ttgcaggcgc atgttaggca cggaactgaa atggccaaat atttcgaatc cttggttaga     1200

agcgacccca gtttcgagat ccccgcgaaa agacatctgg gtctagtagt tttcagactt     1260

aaaggtccta attgtttgac agagtcagtt ttgaaggaga tcgcaaaagc gggtcagtta     1320

tttttgatac cagcgacaat acaagacaaa ttgataatca ggtttacggt cacatcacag     1380

tttactacaa aggaggatat attacgtgat tggcacttaa tccaagaggc cgcaaatctg     1440

gtcctatctc agcactgcac ttctcagccc agcccccgtg cgaagaatgt gatcccaccc     1500

ccgcctggta cacgtggatt aagcttagaa tctgtttctg aaggaggtga tgatccggca     1560

caagcaagga aaataatcaa gcaaccaggg gctagcttgg cgcgtcgtga aggcggttcc     1620

gatttggaga caatgccgga ccccttcgac gattgtttca gtgaagaagc gccaaacacg     1680

acaaagcaca aattgtcaag ctttttattt agctatttat cagttcaaaa cagacgtaag     1740

acaacacgtt ccctgagctg taatagtgta ccaatgagcg cacaaaaatc attgccagct     1800

gacgcatctt tgaagaacgg tggaagtttc cgtgcaagaa ttttttctgg gtttcccgaa     1860

caaatgatga tgatgaagaa gggggcattc aagaagttaa taaagttcta tagtgtacct     1920

agtttcccgg agtgcagtag ccagtgcgcg cgtcaactac cctgttgtcc gttagaagct     1980

atggtt                                                                1986


<210>  85
<211>  2541
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  85
atggacttta aggagtatag gcagagaggt aaagaaatgg tagactatat agcagactac       60

ttggaaaata ttcgtgaaag acgtgtattc cccgatgtct caccaggcta tatgcgtcag      120

ttattaccag aaagcgcccc catagagggg gagccttggc ccaaaatctt cagcgatgta      180

gaacgtatcg ttatgcccgg gataacccat tggcaatccc cgcatatgca tgcgtatttt      240

ccggccctga actcaatgcc aagtctgttg ggggatatgc tagccgacgc catcaattgt      300

ctgggtttta cctgggcttc ttcaccagcc tgcacggagc tggagatcat cgtgatgaac      360

tggttgggaa aaatgattgg actgcctgac gcttttctac acttatcctc ccaatcccaa      420

ggtgggggcg tcttacagac aactgccagc gaggccacgc tggtgtgcct tctagctggt      480

cgtactagag caatacagag gttccacgaa agacatcctg ggtaccagga cgctgaaata      540

aacgctagat tagttgccta ttgcagcgac caggcgcatt cttctgttga gaaagcggca      600

ctaataggcc tagtgagaat gagatatatt gaggccgatg atgatctggc gatgagaggg      660

aagcttctgc gtgaagctat tgaagacgac atcaaacaag ggttggtccc tttctgggtg      720

tgtgctacac taggcacaac cgggagctgt tcatttgata atctggagga gatcggaata      780

gtttgcgcag agcatcacct atggttacac gtagatgctg cttatgcagg atcagctttt      840

atatgtcctg agtttcgtac atggctgagg gggattgaac gtgcggacag catcgctttt      900

aacccatcca agtggttgat ggttcacttt gatgctacgg cactgtgggt cagggatagt      960

acagccgtac acagaacatt caatgtcgag cccctttatc tgcaacacga gaactctggt     1020

gtagcagttg attttatgca ttggcagatc ccattatcaa ggcgttttag agccctgaaa     1080

gtatggttcg ttctgaggag ctatggtata aaagggttac aaagacatat aagggaggga     1140

gtgaggttgg cacagaaatt tgaggctttg gtcttggccg atcacaggtt cgaactaccc     1200

gcgaaaagac acctgggact ggttgttttc cgtatcagag gcgataatga aataacagag     1260

aaattgctga agagattgaa tcatcgtggc aacttacact gtataccctc atccctaaaa     1320

ggacaatacg tcataaggtt tactatcacc tccactcaca cgacactgga tgatatagta     1380

aaagactgga tggaaatacg tcaggtcgcc agtaccgtgt tagaagagat gaacataacg     1440

attagcaata gagtttatct taaagagaca aaagaaaaga acgaggcgtt tggttcttct     1500

ttattgctgt ctaacagccc tctatcccct aaggtagtaa acggctcctt tgctgcaatc     1560

ttcgacgcgg acgagttcct agcgaaaaca tacgcaggcg tcaggatcgc tcatcaagaa     1620

tctcctagta tgcgtaggag ggtcagagga atcttgatgt ctggaaagca attttcctta     1680

gattcacaca tggatgttgt tgtccaaacc acacttgacg ctgggaatgg tgcaacgaga     1740

acttcaacca ctaatagcta cggacatacg acgagcgcgg cgcaggccaa ttccgaaagg     1800

caagctagca tacaagaaga taacgaagag tccccggaag aaactgaact tctgagtcta     1860

tgcaggacat ccaacgtccc gagtccagaa catgcgcatt cattgtctac accaagcagg     1920

tcctgttcat cttcatctca ctcccttatc cattcactta cccaatccag ccctcgtagt     1980

tcacccgtca atcagttcag gccgattact ctttgcgcgg tcccgtccca atctcaactt     2040

tccatgccgt tggctatgcc actaccaaat agaaacgtta cagtttctgt agattctctt     2100

ctaaaccctg taactacatg taatgtatat catggcaaaa gatttctgga gccactggaa     2160

aacctggccc agacgagcgc aagttttagc agctcaattt ttagacttcc aacaccgatc     2220

gcaacgccga ccagagagtc cccagaagat cctgattggc cggctaagac attcagtcaa     2280

ttgctgttgg agaggtactc cagccagtcc cagtcattag gtaacaactc tagcaccgaa     2340

tcctcatcat tgtccggagg ggctactccc acacctaccc ccatgtccag tttggatgaa     2400

ttggtcacac cgttattatt gtctttcgca tccccttctc aaccgatgct atctgcacat     2460

gggataggcg aaggtcaaag ggagcagggc tctgatagtg atgcaactgt gtgtagtact     2520

acaagctcta tggaaagcct a                                               2541


<210>  86
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  86
atgtctcttt ccccacttga ccagaacagg attgaatctt tctggcaata ttgcttgcag       60

caccaatact tcaacttggc ctaccccgag tcagctgact tcgactatgc ccctttgcac      120

cgttttttgc gtttctccat taataactgc ggcgactgga atgagtcctc aaattacttg      180

ttaaattcat tcgatttcga gagggaagtt atgcacttct ttgccgaatt gttccacatt      240

ccgtttgacg agtcatgggg atacgtgacg aatggcggaa cggaagggaa tatgttcggg      300

tgctacctgg cgagggagct gtttcctgat gcaacccttt actatagtaa agactcccac      360

tacagtgtag ctaagattat aaagttgctg agaatcaaat ccagagcagt agactcacta      420

ccgagcggcg agatagatta cgacgacctt gtagccaaga ttcaacaaga ccaggagaga      480

catccaattg tattcgtaaa tgttggaacg actatgaaag gtgccgtaga tgacatagga      540

gttatccaac ataaacttgc ggaagctggt ataccgcgtc aagattacta cttgcacgcg      600

gatgcggctc tttcaggtat gatcttaccc ttcgtggacg caccacaacc gtactcattt      660

gcggatggga tagactcaat atctgtgagc ggtcataaaa tgataggaag ccctatgcca      720

tgtggtatag tattggcaaa gaggagcaac gtgagtcgta tatctgtaga aatcgattat      780

atatcagcga aagaccagac gatttctggg agtaggaacg gtcacacccc gatgatgttg      840

tgggctgcta ttaaatcaag gcccctagcg gaatggagaa gaaaggttag acattgctta      900

gacatggcac aatacgcaat cgacaggcta caggcggccg ggatacaagc ttggagatgt      960

aagaatagta ttaccgtagt tttccccagc ccctccgaac cggtctgcga caagcatggc     1020

ttagcccgtt ctgggggaac cgcacattta atcaccacgc cccaccacca cgatagtcaa     1080

agattggatc gtctgttaga tgacatagtg caagatttag gcgcgatgac tgcccctgct     1140

ggtgcgacaa tgtctgctgc c                                               1161


<210>  87
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  87
atgcagaaat atgaatacga tccgaagtgg gtaattaata atgcaattag cagtgagcgt       60

gaattttgca ctggctacca aaatccaggt gcgtccggta atggatacgt caccacgatc      120

aaattgagca cagggctagt cgatattacc ccctgggaaa aagttcaagc gatgagtgaa      180

catgaggtaa taaaattcga tagagggtgc agtaatatcg tgagctacga taggtgtgaa      240

tgtaatgatg cctacattgg tgccattaat atgttgacgg ccagctcctt ttcaggactt      300

caaggagtta tctggggtta cgatatagct gttgtcgaga acctgcgttc cagaaaactt      360

tacgaccaaa agtggcccag tggtgatcct aatagtgaat acagtactcc agtctactca      420

atcgagccgc tgttgaacgc aactgagaga ctgtttggac acgcggagcc aggaaaaaga      480

aggtttaatc caatcccagg ttctatggta gtatgtgcca acaaatctgc cactagtgat      540

ccttcctcag acgtcaaaga aggctgggcg ttcagtgtca ttagcttagc aatcttggag      600

aatagaaatt ctggaagtaa cctattcatc gaagattgcg acattatcga tataaacaac      660

ccggacggaa cgcgtaagac gaaagaggac gtgaaggcta tgctggacac tactctacgt      720

aaggtgactg agtgcacggt gctatgtggg ttggaccagc acattaagta caaagaaata      780

ttcattggct acaaagtcat caagtttaat gagaagcaag ttgggtgcgc actagcatgc      840

gcgccttatg ttaccttggc gaggaacgct gttccccagg gtatgaagcc ttcaaagttg      900

acggatatga atatctctca gtgggagaat gcattaaatt tacaaccctt ggagaaaatt      960

gaaaaatcta agattggaat tctgggaatg ggcgttctgg at                        1002


<210>  88
<211>  1047
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  88
atgaccctgc acagtagata tagcaagtta aagggtgaaa ataaaatgca aaagtacgag       60

tatgatccca agtgggttat caataacgct atttctagtg aaagagaatt ctgcacggga      120

taccagaacc ctggggcaag cggcaacggt tatgtgacaa ctatcaaatt gtctaccggc      180

ttagttgata taacaccctg ggagaaagtt caagcaatgt ccgaacacga ggttatcaag      240

tttgataggg ggtgttcaaa catagtcagc tatgaccgtt gtgaatgcaa cgatgcttat      300

atcggtgcaa tcaacatgct aacggcgtct agcttctctg ggctacaagg ggtcatatgg      360

gggtacgaca ttgcggtggt cgaaaatcta agatcaagaa agctgtatga ccagaaatgg      420

cccagtggcg atccaaattc cgaatacagc acgccagtgt actctattga gccacttctt      480

aatgccacag aaagactatt cggacacgca gaaccaggta aaaggagatt taatccaatc      540

ccaggatcaa tggtagtgtg tgctaacaag tccgcaacgt cagatccatc atcagatgta      600

aaagaaggtt gggccttctc tgtgataagc ttggctattt tggagaacag aaatagcggt      660

tctaaccttt ttatcgagga ttgcgacatt atcgacatta acaatccgga tgggacgcgt      720

aagaccaagg aggacgtcaa agcgatgttg gacactacat tgaggaaagt aacggaatgc      780

acagtcctgt gtggtttgga ccagcacata aagtataaag agattttcat agggtataag      840

gtaataaagt tcaatgagaa acaagttggt tgtgcactag catgcgcccc ctatgtaacc      900

ttagccagaa atgcagtacc acaagggatg aagccctcca agctgacgga tatgaacatt      960

agccagtggg agaatgcact taacctacaa ccgttggaaa agatagagaa aagcaaaatc     1020

ggcatcttgg gaatgggcgt gcttgat                                         1047


<210>  89
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  89
atgctaaaga tagcagtacc caacaaaggt agcctaagcg agagagctat ggaaatcttg       60

gctgaggctg gctatgctgg gagaggagac tccaaatctc taaatgtgtt tgacgaggct      120

aataatgttg agtttttttt tcttagacca aaggatatcg ccatatatgt cgcgggagga      180

cagctagacc taggcatcac cggcagggat ctagccaggg acagccaagc agatgtccac      240

gaggtcctgt ctttaggatt tggatcttct accttcaggt atgcagcccc tgccgatgaa      300

gagtggtcta tcgagaagct agatggcaaa cgtatcgcca caagttatcc caatttggtc      360

agggatgatc tagccgcgag aggtttatca gccgaggtcc tgagacttga tggggccgtc      420

gaggttagta tcaaactagg tgttgcggat gcgattgcag acgtggtatc caccggaagg      480

acgctacgtc aacaagggct tgccccattc ggtgaggtgc tgtgcacatc cgaggctgtt      540

atcgtgggaa gaaaagacga aaaggttaca cctgagcagc agatattact aagaaggata      600

cagggaattc tgcacgctca aaactttcta atgctggatt ataaggttga tagggataac      660

ctagacgccg ccacagccgt tactcctggt ttctccggtc ccgctgtcag tcctctagct      720

agggacaact gggtcgccgt cagggctatg gttccaagac gtagcgctaa cgcaataatg      780

gacaaattgg cgggccttgg ggccgaagca atactggcga gcgaaatcag gattgcacgt      840

att                                                                    843


<210>  90
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  90
atgttagata atactcgtct tagaatagcg atacagaaaa gtgggaggct ttccgatgac       60

tctcgtgaat tactagcgag gtgcgggatt aagataaacc ttcatacaca aaggttgatt      120

gcaatggccg agaacatgcc gatagacatt ttaagagtca gggatgatga tatcccagga      180

ctagtgatgg atggggtggt tgatttagga attattggag agaatgtttt agaggaagaa      240

ctgttgaacc gtcgtgcgca aggtgaagat cctaggtacc ttacccttag gagacttgat      300

tttggcggtt gccgtttaag cctagcaact ccagtcgatg aggcatggga cgggcccgct      360

gccctggatg gtaaacgtat agccacatcc tacccacacc tactgaaaag atatctggac      420

cagaaggggg tttctttcaa aagttgtttg cttaacggct ccgtcgaagt cgcgcctcgt      480

gcgggattgg ccgatgcgat atgcgatctg gtctccacgg gtgctaccct ggaggctaat      540

ggccttagag aagtggaagt aatatacagg agcaaagcgt gccttatcca gagagacggt      600

gaaatggccc agagcaaact tatagataag ctactaacga gaattcaagg tgttatccaa      660

gcaagagagt ccaagtatat aatgatgcac gcgccctctg agagattaga ggaggtcatc      720

gcattgttgc caggggcaga acgtcccacc atacttcctc tagcgggtga gcaacagagg      780

gtagccatgc acatggtgtc cagcgaaact ttgttctggg aaacgatgga aaagctaaag      840

gcccttggag cctcttcaat tctagttctg ccgatcgaaa agatgatgga g               891


<210>  91
<211>  738
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  91
atgaccttca ctattcttcc tgcagtcgat gtagttaacg gacaagcagt tcgcctagat       60

cagggcgagg ccggcactga aaaatcttat ggcacccctt tggaatctgc actgaagtgg      120

caggagcagg gtgcaaagtg gttgcacttt gtggacctgg acgcagcgtt caaccgtggt      180

tccaatcatg agatgatggc ggaaattgtc ggcaagctcg atgttgatgt ggagctcact      240

ggcggtatcc gtgatgatga gtctctggag cgcgcgctgg caaccggtgc acgtcgtgta      300

aacattggta ccgctgctct ggagaagcca gagtggattg cttctgcgat tcaacgctat      360

ggcgagaaga ttgctgtcga tatcgctgtg cgtttggaag atggtgaatg gcgcacccgt      420

ggaaacggtt gggtctccga tggtggcgat ctgtgggacg ttctcgagcg tttggattcc      480

caaggttgtg cacgtttcgt ggttaccgat gtgtccaagg acggcacctt gagtggtcca      540

aatgttgagc tgctgcgtga ggttgctgca gctacagacg cacctatcgt ggcatctggt      600

ggaatttctg ttttggaaga tgttttggaa ctagccaagt accaggatga gggcattgat      660

tccgtcatca ttggcaaggc actttatgag cacaagttca ccctcgaaga ggctttggct      720

gcagtagaaa agctcggt                                                    738


<210>  92
<211>  606
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  92
atgactgtcg caccaagaat tggtaccgca acccgcacca ccagcgaatc cgacatcacc       60

gtcgagatca acctggacgg caccggcaaa gtagatatcg ataccggcct gccatttttc      120

gaccacatgc tcactgcatt cggcgtgcac ggcagttttg atctgaaagt ccatgccaag      180

ggcgacatcg agatcgacgc acaccacacc gtggaagata ccgccatcgt gctcggccaa      240

gcactccttg acgctattgg cgacaagaaa ggcatccgcc gtttcgcatc ctgccagctg      300

cccatggatg aggcattagt ggagtccgtg gtggatatct ccggtcgccc atacttcgtg      360

atctccggcg aaccagacca catgatcacc tccgtgatcg gtggacacta cgcaaccgtg      420

atcaacgagc acttctttga aaccctcgcg ctcaactccc gaatcaccct ccacgtgatc      480

tgccactacg gccgcgaccc tcaccacatc accgaagcag agtacaaggc tgttgcccgt      540

gcgctgcgcg gtgccgtaga gatggatcct cgtcaaacag gaatcccatc caccaaggga      600

gcgctc                                                                 606


<210>  93
<211>  1098
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  93
atgaccaaaa ttactttgag cgatttgcca ttgcgtgaag aactgcgcgg tgagcacgct       60

tacggcgcac cccagctcaa cgttgatatt cgcctcaaca ccaacgaaaa cccttaccca      120

ccgtcagagg cattggtcgc tgacttggtt gccaccgtgg ataagatcgc caccgagctg      180

aaccgctacc cagagcgcga tgctgtggaa ctgcgtgatg agttggctgc gtacatcacc      240

aagcaaaccg gcgtggctgt caccagggat aacctgtggg ctgccaatgg ttccaatgaa      300

attctgcagc agctgctgca ggcttttggt ggacctggac gcaccgcatt gggattccaa      360

cccagctatt ccatgcaccc aattttggct aaaggcaccc acactgaatt cattgcggtg      420

tcccgaggtg ctgatttccg catcgatatg gatgtggcgc tggaagaaat tcgtgcaaag      480

cagcctgaca ttgtttttgt caccaccccg aacaacccga ccggtgatgt gacctcgctg      540

gacgatattg agcgcatcat caacgttgcc ccaggcatcg tgatcgtgga tgaagcttat      600

gcggaattct ccccatcacc ttcagcaacc actcttctgg agaagtaccc aaccaagctg      660

gtggtgtccc gcaccatgag taaggctttt gatttcgcag gtggacgcct cggctacttc      720

gtggccaacc cagcgtttat cgacgccgtg atgctagtcc gccttccgta tcatctttca      780

gcgctaagcc aagcagccgc aatcgtagcg ctgcgtcact ccgctgacac gctgggaacc      840

gtcgaaaagc tctctgtaga gcgtgttcgc gtggcagcac gcttggagga actgggctac      900

gctgtggtgc caagtgagtc caactttgtg ttctttggag atttctccga tcagcacgct      960

gcatggcagg catttttgga taggggagtg ctcatccgcg atgtgggaat cgccgggcac     1020

ttgcgcacta ccattggtgt gcctgaggaa aatgatgcgt ttttggacgc agctgcagag     1080

atcatcaagc tgaacctg                                                   1098


<210>  94
<211>  1326
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  94
atgttgaatg tcactgacct gcgaggtcaa acaccatcca agagcgacat ccgacgtgct       60

ttgccacgtg gtggcactga cgtgtggtct gtgcttccca tagtgcagcc tgttgtagaa      120

gatgtccaaa accgcggcgc tgaagctgct ttggattacg gcgagaagtt cgaccatatt      180

cgccccgcct cggtgcgggt gccagctgag gttattgctg cagcagaaaa caccttggat      240

ccgttggtgc gtgaatcgat tgaagagtcg attcgtcgcg tccgcaaggt tcacgctgag      300

caaaagccag ccgagcacac cactgaactt tcaccaggtg gcaccgtcac tgagcgtttc      360

atgccgattg atcgcgtggg actgtacgtt ccaggcggca atgcggtgta cccatcaagc      420

gtgattatga atactgtccc agctcaagag gctggtgtga actcccttgt ggttgcgtcg      480

cctcctcagg ctgagcacgg tggctggcct caccccacca ttttggcggc gtgttccatc      540

ttgggtgttg atgaggtgtg ggctgtcggc ggcggtcagg ccgtggcgtt gctggcttat      600

ggtgatgacg ctgcaggtct cgagcctgtg gatatgatca ctggacctgg caatatcttt      660

gtcaccgctg cgaagcgcct ggtcagggga gtggtaggta ctgattctga ggctggccct      720

acagaaatcg ctgtgcttgc tgatgcctct gccaacgccg tcaacgttgc ctacgatctg      780

atcagccaag cagaacacga tgtcatggct gcgtccgtgc tcatcactga ctccgagcag      840

cttgccaagg acgtaaacag ggaaatcgag gcgcgttact caatcacgcg caacgccgag      900

cgcgtcgcag aagctttgcg cggggcccag agtggcatcg tgcttgtcga cgacatttcc      960

gtgggtatcc aagtagccga tcaatacgca gcggaacacc tggaaatcca cactgagaac     1020

gcgcgcgccg tagcagagca gatcaccaac gcgggtgcga tcttcgtggg cgatttctca     1080

ccagtaccac tgggtgatta ctccgcagga tccaaccacg tgctgccaac ctctggatcc     1140

gctcgtttct ccgcaggtct atccacgcac atgttccttc gcccagtcaa cctcattgaa     1200

tacgatgagg ctgctctgaa ggacgtctcg caggttgtca tcaactttgc caacgccgaa     1260

gatcttccag cgcacggcga agcaatccgt gcacgctttg aaaacctccc caccaccgac     1320

gaggcc                                                                1326


<210>  95
<211>  261
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  95
gtgaagacat ttgactcgct gtacgaagaa cttcttaacc gtgctcagac ccgccctgaa       60

gggtctggaa ccgtggccgc cttggataaa ggcatccatc atctaggtaa gaaggtcatc      120

gaagaagccg gagaggtctg gattgcagcc gagtatgaga ccgatgaaga gctagccgga      180

gaaatctccc agctcattta ttggacccag gtcatcatgg ttgctcgcgg cctgaagcca      240

gaagatatct acaagaacct g                                                261


<210>  96
<211>  774
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  96
atgggcgtgg caattcgagt tattccttgc ctggacgtgg acaacggccg ggttgttaaa       60

ggcgtgaact ttgaaaacct ccgcgatgct ggcgatcctg tggagttggc aaagcgctat      120

gacgaggaag gggcagatga gctgaccttc ttggatgtca ccgcctcgaa gcatggtcgc      180

ggcaccatgc tggatgttgt tcgacgcacc gctgatcagg tgttcatccc tctgactgtc      240

ggtggcggcg tgcgcagcga agaagatgtt gatcaattgc tgcgcgcggg cgccgacaag      300

gtttcggtga acacgtctgc gattgcccgt ccagaactgc tatcagagct gtccaagcgt      360

tttggtgctc agtgcatcgt gttgtctgtg gatgccaggc gcgttcctga aggtggaact      420

cctcagccat ctggttttga agtcaccact cacggcggtt ccaagtccgc agaacttgat      480

gcaatcgagt gggcaaagcg cggcgaagag ctgggcgttg gcgaaattct gctcaactcc      540

atggacggcg acggcaccaa aaacggcttt gacctagagc tgctggaaaa agttcgcgca      600

gccgtatcca ttcctgtaat cgcctccggc ggcgctggca aggcggagca tttcccacca      660

gctgttgcag ctggcgccaa cgcagtgctt gccgcgacca ttttccactt ccgcgaagta      720

accatcgccg aagtaaaggg agccattaaa gatgcaggat ttgaggtgcg gaaa            774


<210>  97
<211>  633
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  97
atgaccaaaa ctgtcgccct tctcgactac ggatctggaa accttcgttc tgctcaacgc       60

gcattagagc gtgctggtgc agaagttacc gtgagctctg atccagaagt ttgcaccaac      120

gctgatggcc tcctagttcc tggggtgggc gcatttgatg cctgcatgaa gggtttgaaa      180

aacgtcttcg gacatcgcat tatcggacag cgtcttgctg gtgggcgtcc agtgatgggt      240

atttgtgtgg gcatgcagat cctgtttgat gaaggcgatg agcatggcat taagtcagct      300

ggttgtggcg agtggcctgg caaggtggaa cgcctccagg cggagatcct gcctcacatg      360

gggtggaaca cacttgaaat gcctaccaac tcaccaatgt ttgagggaat ttcacctgat      420

gagcgtttct acttcgtgca ctcctatggt gtgcgcaagt ggacgttgga aaccgacgat      480

ctgaccacgc ctccagaggt tgtgtgggcg aagcacgaaa atgatcgttt tgtggctgct      540

gtggaaaacg gcacgctgtg ggctactcaa ttccacccag aaaaatcagg tgacgtaggc      600

gcaaagctac tgcgaaactg gatcaactac atc                                   633


<210>  98
<211>  354
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  98
atgagtgaca atccacaaga gtatgagctg gattgggacg tcgaaaagcg attaaagctt       60

aacgacgccg gcctggtgcc ggcaatcgtc caggccgacg ggaccaacga ggtcctcatg      120

atggcctgga tggataccca cgcgctagcc tatactttgg cgacccgccg tggaacctat      180

ttttctaggt cccgcaacga gtactggatc aagggcctga cctctggaaa cgtccaagaa      240

gtcaccggac ttgccctcga ctgcgacggc gacactgtcc ttctgaccgt gaaacaaacc      300

ggcggtgcgt gccacactgg tgcccacaca tgtttcgaca atgacgtttt gctg            354


<210>  99
<211>  891
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  99
atggatttgg tgaaccatct aaccgataga ctactgtttg caatcccaaa gaaaggtcgt       60

ttatattcta aaagtgtttc tattttgaat ggtgctgata ttacatttca ccgctctcaa      120

agattagaca ttgcactaag cacaagctta cctgtagcgt tgatctttct gcccgctgca      180

gatattccaa cttttgttgg tgaaggtaaa tgtgatcttg gtataactgg tgttgaccaa      240

gttcgtgaat ctgacgtcga cgtagactta gcaatcgatt tgcaatttgg taactgtaaa      300

ttgcaggtac aagtccccgt aaatggcgag tataaaaagc cagaacagtt aattggcaaa      360

accattgtta ccagtttcgt gaaacttgct gaaaaatact ttgccgattt ggaaggtact      420

actgttgaaa aaatgaccac aaggataaag tttgtcagtg gttccgtgga ggcatcatgt      480

gctctgggaa ttggtgatgc tattgtagat cttgtagaga gtggtgagac aatgagggca      540

gcaggtttag ttgatattgc caccgtccta agcacaagtg cctacctaat agaatcaaag      600

aacccaaaga gcgataagag tttgattgct actatcaaat caagaattga aggtgtcatg      660

accgctcaaa ggttcgtttc atgtatttat aacgcacctg aagacaagct gcctgaactg      720

ttgaaggtga cgcctggccg tagagcacca accatttcca aaattgacga tgaaggatgg      780

gttgctgtta gttccatgat tgagagaaaa acgaagggtg ttgttttaga tgaattgaaa      840

agactcggcg catctgatat catggttttc gaaatttcta attgtcgtgt a               891


<210>  100
<211>  1656
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  100
atgccggtcg ttcacgtgat tgacgttgaa agtggtaacc tacagtcact aaccaatgca       60

attgagcatt taggttacga agtacaactg gtgaaatcac caaaggattt taacatatca      120

ggcacgtcaa gattgatttt gcctggtgtc ggaaattatg gccatttcgt cgacaattta      180

tttaatagag gattcgaaaa gccgataaga gaatacattg aatctggaaa accaataatg      240

ggaatttgcg tcgggctaca agcgctcttt gccggttccg tggaaagccc taagagtacg      300

ggtctgaact acattgattt taagttgtcc aggttcgatg attcagaaaa gccagtacca      360

gaaataggtt ggaattcttg cattccctcg gaaaacctat tctttggatt ggatccatac      420

aagaggtact atttcgtcca ttcttttgct gccattctga attcagaaaa gaaaaaaaac      480

ctagaaaatg acggttggaa aattgcaaaa gctaagtacg gttcagagga atttattgcg      540

gcagtcaaca agaataatat attcgctact cagttccatc ctgaaaaatc aggtaaagct      600

ggtttgaacg tcattgagaa ttttttgaag caacaaagtc ctccgattcc aaactatagt      660

gcggaagaga aggaactctt aatgaatgac tattcaaatt atggtctaac acgcagaatt      720

attgcttgtc ttgatgtacg tactaatgac caaggtgatt tggtggttac taaaggtgat      780

caatacgatg tacgtgaaaa aagtgatggt aaaggtgtta gaaaccttgg taagcctgtt      840

cagttggcac agaaatatta ccaacagggt gcggatgaag taacattttt gaatataact      900

tcttttagag attgtccttt gaaggatact ccgatgctag aggttctgaa acaagccgca      960

aagacagtct ttgttccatt gacagtcggt ggggggatca aggatattgt cgatgttgat     1020

ggaaccaaaa tacctgcttt agaagttgca agtctatact tcagatctgg tgctgataaa     1080

gtatcgatcg gtacggatgc agtctatgca gccgaaaaat actacgagtt gggtaacaga     1140

ggagatggaa cgtcaccaat agagacaatc tcgaaagcat acggtgctca ggcagttgtt     1200

atttctgtcg atcctaagag agtatatgta aattcacaag cagatacgaa gaacaaagtc     1260

ttcgagacag aatatccggg ccccaatgga gagaaatact gctggtacca atgtacaatc     1320

aaaggtggaa gagaatctag agaccttggt gtgtgggaat taacaagggc atgtgaagct     1380

ctaggtgctg gggagatttt attgaactgc atagacaagg atggctctaa ttctggttat     1440

gatctggaat tgatagaaca tgttaaagat gcggtcaaga ttcccgtcat tgcatccagt     1500

ggcgccggtg tacccgaaca tttcgaagag gccttcctaa agacccgcgc agatgcttgc     1560

ttgggtgcag gtatgttcca cagaggtgaa ttcactgtta acgatgtaaa ggagtattta     1620

ctagagcacg gattaaaggt tagaatggat gaagag                               1656


<210>  101
<211>  1158
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  101
atggtttttg atttgaaaag aattgttaga ccaaaaattt ataacttgga accttatcgc       60

tgtgcaagag atgatttcac cgagggtata ttgctagacg ccaatgaaaa tgcccatgga      120

cctactccag ttgaattgag caagaccaat ttacatcgtt acccggatcc tcaccaattg      180

gaattcaaga ccgcaatgac gaaatacagg aacaaaacaa gcagttatgc caatgaccca      240

gaggtaaaac ctttaactgc tgacaatctg tgcctaggtg tgggatctga tgagagtatt      300

gatgctatta ttagagcatg ctgtgttccc gggaaagaaa agattctggt tcttccacca      360

acatattcta tgtactctgt ttgtgcaaac attaatgata tagaagtcgt ccaatgtcct      420

ttaactgttt ccgacggttc ttttcaaatg gataccgaag ctgtattaac cattttgaaa      480

aacgactcgc taattaagtt gatgttcgtt acttcaccag gtaatccaac cggagccaaa      540

attaagacca gtttaatcga aaaggtctta cagaattggg acaatgggtt agtcgttgtt      600

gatgaagctt acgtagattt ttgtggtggc tctacagctc cactagtcac caagtatcct      660

aacttggtta ctttgcaaac tctatccaag tcattcggtt tagccgggat taggttgggt      720

atgacatatg caacagcaga gttggccaga attttaaatg caatgaaggc gccttataat      780

atttcctccc tagcctctga atatgcacta aaagctgttc aagacagtaa tctaaagaag      840

atggaagcca cttcgaaaat aatcaatgaa gagaaaatgc gcctcttaaa ggaattaact      900

gctttggatt acgttgatga ccaatatgtt ggtggattag atgctaattt tcttttaata      960

cggatcaacg ggggtgacaa tgtcttggca aagaagttat attaccaatt ggctactcaa     1020

tctggggttg tcgtcagatt tagaggtaac gaattaggct gttccggatg tttgagaatt     1080

accgttggaa cccatgagga gaacacacat ttgataaagt acttcaagga gacgttatat     1140

aagctggcca atgaataa                                                   1158


<210>  102
<211>  660
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  102
atgacagagc agaaagccct agtaaagcgt attacaaatg aaaccaagat tcagattgcg       60

atctctttaa agggtggtcc cctagcgata gagcactcga tcttcccaga aaaagaggca      120

gaagcagtag cagaacaggc cacacaatcg caagtgatta acgtccacac aggtataggg      180

tttctggacc atatgataca tgctctggcc aagcattccg gctggtcgct aatcgttgag      240

tgcattggtg acttacacat agacgaccat cacaccactg aagactgcgg gattgctctc      300

ggtcaagctt ttaaagaggc cctaggggcc gtgcgtggag taaaaaggtt tggatcagga      360

tttgcgcctt tggatgaggc actttccaga gcggtggtag atctttcgaa caggccgtac      420

gcagttgtcg aacttggttt gcaaagggag aaagtaggag atctctcttg cgagatgatc      480

ccgcattttc ttgaaagctt tgcagaggct agcagaatta ccctccacgt tgattgtctg      540

cgaggcaaga atgatcatca ccgtagtgag agtgcgttca aggctcttgc ggttgccata      600

agagaagcca cctcgcccaa tggtaccaac gatgttccct ccaccaaagg tgttcttatg      660


<210>  103
<211>  1005
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  103
atgcactcac accattcaca ctccggtgac tatagtgccc acggtacgga ccctttggat       60

tccgtggtcg atcaggtggt caacctcaac tttcacacgt actgtttgac agagcacata      120

ccaagaattg aggccaagtt tatatacccc gaagagcagt cattgggcaa gaatcctgag      180

gaagtcataa gcaagctaga aacatcgttc aagaatttca tgagtcatgc gcaagaaatc      240

aagactcgtt acgctgatag acccgatgtg cggactaaat tcattatagg aatggagatc      300

gaaagttgtg acatggctca tatcgaatat gcaaagcgac tcatgaagga gaataatgat      360

actttgaagt tttgtgtggg ttcggtccat cacgtcaacg ggatccctat tgatttcgac      420

caacaacaat ggtacaattc attgcattcc ttcaatgata atttgaaaga ttttctcctg      480

tcttacttcc aatcacagta cgaaatgctg atcaatatta aaccgttggt cgtgggtcac      540

ttcgaccttt acaaattatt tttgcccaat gacatgctag taaaccagaa atcgggcaac      600

tgcaacgaag aaaccggagt tcctgtagct tcactggacg tcatcagtga atggccagaa      660

atatacgatg cagttgtaag aaatttacaa tttatagact cctatggcgg cgcaattgaa      720

atcaatacgt ccgcattaag aaagggcctc gaggagccgt accccagcaa aaccttatgt      780

aatctggtca agaagcactg tggatccaga tttgttctaa gtgatgacgc acacggcgtg      840

gcgcaagtgg gtgtgtgcta tgacaaggta aagaaataca tagtagacgt gctacaatta      900

gagtacattt gctaccttga ggaaagccaa tcaccagaga atgtgttaac tgtaaagaga      960

ttacccattt cgcaattcgt taatgatccc ttttgggcca atata                     1005


<210>  104
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  104
atggcaaaaa ttgataaaat tctcaatcag gaaggcattg accgcattgc aatcaatcca       60

taccagaaat acagccgtgg atatatggaa ccgggcaacc ttggaggagg ctacgtgacc      120

ggtctcaagg tggatgcagg cacccgtgaa aagactgacg actctatgct ggatggcatt      180

gtgtcttatg atcgcgccga atgcaaaaat gcctacatcg gccagatcaa catgatgacc      240

gcatccagct ttacgggcgt gcaaggccac atccttggat atgatctgct gcgcaaccct      300

gccgttgaca aggcccagcc cctcttttat gaaacacaat gggatggtag caaactgcca      360

atctatgacg gcaagcctct tcaagattcc ttggtagaat ttttcggtac cgcggacaat      420

cgacgccatt atccagcccc gggatctttt atcgtatgtg ctaataaggg tgttaccgct      480

gaacgaccac ttgaggatcg accattgaat cctggagaag catacggtgt gtggtcagca      540

atcgctattt caattgcaaa ggacccggtc cataactcct ctatgtttat cgaggatgcg      600

ggtacctgga acacgccgaa cgaagatgac cttaacgagt tcctgtatca tcgccgcgaa      660

gccattgcac gcagcattgc gcaatgtggc caagacgcct caacttcatt tgcatcctcc      720

tggattggct tcgcacatgt gatgatgaag ccaggcgaga ttggcaacgc cattacggtc      780

ggcccgtact tcagcatgcc tgttgacgcc gttccaggtg gctctattct cactccggat      840

gttgatatga acattatgga agacctctcc ctccctgaat ggcttgaaaa gatgggctac      900

caatccattg tggaaaacca agacatccag tat                                   933


<210>  105
<211>  1170
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  105
atgtgccgcc atgcgtgcat cgccttggca atgggaatga ttatgggcct ttcatcagag       60

gacgccggaa agatcgaatc gttctggcgc tattgcgtgc agcaccaata cttcaatatc      120

ggttatcccg aggcagctga ttttgactac tccgccctta atcgttttct gaacttctct      180

attaacaact gcggagattg gtcacagcaa tccaactacc tcctgaactc gttcgacttc      240

gaacgtgaag tcatgcagtt cttcgctact ctgttctgca tcccattcga acagtcctgg      300

ggttatgtga caaacggcgg cactgagggc aacatgttcg gttgctactt ggctcgtgag      360

ctcttcccag aagccaccct gtactactcc aaggacaccc attacagcgt cgctaaaatc      420

atccgactct tgcgcgtgaa atcttgcatg gtggactccc tcccgaatgg tgaaatgaac      480

tacgatgact tgatcaatcg catccgtctg gatggagaac gccacccgat catctttgca      540

aacatcggca ctaccatgac cggcgctacg gataacatcg caacgatcca acgccgtctc      600

aaaaagatcg gtattactaa gggcgattac tacctgcacg ctgacgcagc actgtctggc      660

atgatcttgc ctttcattga taacccacaa ccgttcagct tcgcagatgg tgttgactct      720

atttccgtgt ccggacacaa gatgattgga tctccgatcc cctgcggtat cgtgcttgca      780

cgccgtaaac acgtcgaaca cgtttctgtc gagattgatt acatttcagc ttgcgatcag      840

actatctccg gttcccgcaa cggttatact cctttgctgc tctggatggc cattaagtcc      900

cgctccttct ccgactggcg tcagcgtacc cagcactgcc tcgacatggc gcagtacgta      960

attgaacgct tccatgctaa gggtatccac gcttggcgca atcccaactc catcaccgtt     1020

gtcttcccga aaccagctga tcacatctgg aagaagcact gcctcgccac ctctggtaag     1080

atctcacaca tcatcacgat gccacatcac accggcaaag agactctgga tcgcgttatc     1140

aatgacatcg ctctcgaccg tgagccaaag                                      1170


<210>  106
<211>  1134
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  106
atgacgctga gcatcaacga ccaaaacaag ttggatgctt tctgggcata ctgtgttaaa       60

aaccaatatt ttaacatcgg ctaccctgaa agcgctgatt ttgactacac caaccttgag      120

cgctttttgc gcttttcaat caacaactgt ggtgattggg gcgaatattg caattacctg      180

ttgaactcct tcgacttcga gaaggaagtg atggaatatt tcgctgacct cttcaagatc      240

ccattcgaga agtcctgggg atacgtcacc aacggcggaa cggaaggcaa catgttcggt      300

tgctatctgg gccgagaaat ttttcccgat ggtaccctgt actactctaa agatacacac      360

tattcagtgg cgaagatcgt taagcttctc cgaatcaagt ctcaggtagt agaagcccaa      420

ccaaacggcg aaattgatta cgatgatctt atgaagaaga ttgcagcaga caaggaggcc      480

cacccaatta tctttgccaa tatcggtacc accgtacgcg gagctatcga cgatatcacc      540

gagatccaga aacgcatgaa ggccgccggc atcaagcgcg aggactacta cctgcatgca      600

gacgctgccc tctccggcat gatcctgcct tttgtggatg aacctcaggc cttcaccttt      660

gctgatggca ttgactccat tggcgtctcc ggtcataaga tgatcggcag cccgattccg      720

tgcggcatcg ttgtggcgaa aaaggaaaat gtggatcgca tctcagtgga aattgactat      780

atctcagcac atgacaaaac tatcactggc tcacgtaacg gccacacgcc actcatgctc      840

tgggaggcgg tgcgcgcgca ctctacggaa gattggaagc gtcgtatcgg tcgctctttg      900

gatatggcgc agtacgcagt agaccgtctg cagaaggccg gcatcaatgc ttggcgtaac      960

aaaaactcca ttaccgtcgt gtttccgtgc ccgagcgagc gtgtgtggaa ggaacactgc     1020

ctcgcaacct ctggtaatga tgcacatctg atcaccaccg cacaccattt ggacactgct     1080

cagattgatg ccctgatcga cgacgttatt gcagatgcca agctccacgc tgct           1134


<210>  107
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  107
atgcttaaga ttgcagtccc aaacaaaggt agcttgtccg agcgtgccat ggagatcttg       60

gccgaagcag gctatgccgg ccgtggcgat tcaaaatcgc ttaacgtctt cgacgaagcg      120

aataatgttg aatttttctt cctccgaccg aaagatatcg ctatttacgt ggcaggcggc      180

caattggacc tgggcattac aggacgagac ttggcacgag attcccaggc ggacgtgcac      240

gaggtactga gcctgggatt cggctctagc acctttcgct atgcagctcc agccgacgag      300

gaatggagca tcgaaaagct cgatggtaag cgcatcgcaa cctcttaccc aaacctggtg      360

cgcgatgatc tcgcggcccg cggcctttcg gcagaagtgc ttcgccttga tggtgcagtt      420

gaagtcagca tcaagctggg agtcgccgat gccattgcag atgtcgtctc tacgggacgc      480

acattgcgcc aacagggact cgctcctttc ggagaggtgc tctgcacctc ggaagcggtg      540

atcgtaggcc gcaaggacga aaaggtcaca ccagagcagc agatcctcct ccgccgaatt      600

caaggcatcc tgcacgcaca gaactttctt atgctggatt acaacgttga ccgcgataat      660

ctggacgcag cgaccgcggt cacccccgga ctctccggtc ccaccgtgtc gccacttgct      720

cgtgataatt gggttgcggt gcgtgctatg gtcccccgcc gcagcgcgaa cgctattatg      780

gataaactgg cgggacttgg cgcggaagcc atccttgcat ccgaaatccg cattgcgcga      840

att                                                                    843


<210>  108
<211>  945
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  108
atgcctgaca tgaaattgtt cgcgggcaat gcgacacctg agctcgctca acgaatcgcc       60

aatcgactgt acaccagcct tggagatgcg gcggttggac gcttttcgga tggcgaggtt      120

tccgtacaga tcaacgaaaa cgtgcgcggc ggcgacatct tcatcattca gtccacgtgc      180

gctcccacca acgacaatct gatggaactg gttgttatgg tcgatgccct gcgccgcgca      240

tcggctggtc gcatcacagc agtgattcca tattttggct acgctcgcca ggatcgacgt      300

gtgcgatcgg cccgcgttcc catcaccgcc aaagtcgtgg cggatttcct ttcctctgtg      360

ggagttgacc gtgtgctcac tgtagacttg catgcggaac agattcaagg cttctttgat      420

gtgcctgttg acaacgtttt cggcagccct atcctgctcg aagatatgct ccaactgaac      480

ctcgataatc ctattgtcgt ttcaccagat attggtggtg tcgttcgtgc tcgagcaatc      540

gcgaagcttc tcaacgatac cgatatggca attatcgaca aacgtcgccc acgcgcgaac      600

gtttcacaag ttatgcatat tattggtgat gttgccggcc gcgattgcgt gttggtggat      660

gatatgatcg acactggcgg cactttgtgc aaagcggcgg aagccctgaa ggaacgcggc      720

gccaaacgcg tatttgcata cgccacccac ccaattttct ctggcaatgc cgcgaacaac      780

ctgcgcaact ccgtgatcga tgaagttgtg gtgtgtgata cgatcccctt gtctgacgaa      840

atcaaatccc tcccgaacgt gcgcacactg actctctcag gcatgctggc cgaggccatt      900

cgacgaatct ctaacgagga gagcatctcc gcaatgtttg aacat                      945


<210>  109
<211>  1488
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  109
atgtctatgt ccaatattgt cgttttcgga ggagactcgc acccagaatt ggtgaccaag       60

atttgcgaaa atcttgacat tcaccccagc aaggttgagc tgggcaaatt ttctaacggt      120

gaaactaaca tcgcactgcg tgaatcggtc cgagagaaag acgtctacat cattcagtcg      180

ggctgcggtc aagtgaacga tactttcatg caactgttga tcctcatctc cgcatgtaag      240

agcgcttccg catcccgtgt caccgcagtc atgccatacc tttgctattc gcgacaacca      300

gacatccctt acacagcgaa gggagcaccc attatttcca agccgaaaga aaactatacg      360

tttgaatcac atccaggaac ccccgtgtcc tcctccctta tgacccagcg acccggcgcg      420

gagtcgagcc ttaaaagctt ggattcagct atccgaagca ccatcaatct ggagaacccg      480

cagccaatcc gcactcccaa ttcttctgca accgcgaata acaactttga tattaagaaa      540

accctgagct tctcacgtat cccaatgatc cccggcggaa aactgcagaa tacttcgaac      600

tctaccgatg cgggcgaact cttcaatgct caaaacgccg gatacaagct ttgggttgtc      660

caagcaggaa ccctgatcgc acacctgctg tctgccgctg gtgccgatca cgtcatcacc      720

atggatctgc atgacccaca attcccagga ttctttgata ttcctgtaga taacctgtat      780

tgcaaaccca tcgctcaaaa ctatattcag caccgcattc ccgattacca agatgctgtt      840

atcgtgtctc ccgacgctgg cggcgccaag cgcgctaccg ctatcgcgga tgcattggaa      900

ctctcctttg ctttgatcca caaggaacgc cgaagccagc tgcttaaggg acctccagat      960

gccactctga cttcaggcgg ctctctgcct gtttcccccc gcccactcgt tacgaccctg     1020

gtctcctctc agaatacgac ttcctccggt gctacaggtg tggctgctct cgaaatgaag     1080

aaaactacct ccacaagctc cacctcatcg cagtccagca attcatctaa gtttgtccag     1140

accacaatgc ttgttggcga tgtccgcaat aaggtgtgca ttattgtcga tgacctggta     1200

gacactagct ataccattac ccgtgcagcc aaactcctca aggaccaggg ctcgacgaaa     1260

gtttacgccc tgattactca cggcgtattc agcggcgacg ctctggagcg cattggtcag     1320

agctccatcg ataagctgat catctctaac acagtccccc aggaccgtac cttgcaatac     1380

ctgggaaagg accgcgttga cgtaattgat gtgtcctgca tcatcggcga ggctatccgc     1440

cgtatccata acggagaatc gatctctatg ctgttcgagc atggttgg                  1488


<210>  110
<211>  1281
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  110
atgcgtaaat gcaaaatctt cgtgggaaac tcacacccag aactgggaaa catggtatgc       60

caacgcttgg gtatcgagcc cgcaccttgt acccttaaaa agttcgccaa cggagagacc      120

tccgtccaaa tcggcgtgag cgtccgcgat gaagatgtct acgtgattca gtccggttcc      180

ccttcaatca acgatgacat tatggaattg ctgattctcg tttcagcgtg ccgaggcggt      240

tccgcccgta agatcaccgc tgtgatccca cagtttccat actcgaaaca gtgcaagatg      300

aaacgacacc gcggagcaat taccgcacgc atgctggcaa acttgcttgt catggcagga      360

gccgaccatg tggtatcgat ggatctgcat gcatcccaga tgcagggttt ctttaccaag      420

ccagttgaca acctttacgg aggcccgtca cttgccaaat ggatccgaga gaacgtcgaa      480

gactacgagg acgcagtagt tgtctcaaag aaccccggcg gaaccaagcg tgttaccgca      540

cttgcagact ctctcaagat caacttcgcc atgatccaca ccgatcgccg ccgtagcaag      600

gacctttatt cgcagaataa ggacctccaa caactgaagt tgcgtaaaca gtccatgctc      660

cgcaagaacc gtcccatcat tcgacagggc gatcatccaa acgaagaaga aaatattatt      720

ttgtcgaacg gcattcagac ggcccgtatc cgcaacggtc atgtgatcgg cgacgatgag      780

gccgacgatg acgaagatgc aattctcgaa agcgactcag agcttcactc catcgatggc      840

ctcgactcgc acggcctcgg aggcacttat gacgcagttg actccgaaga tgaagaagag      900

atcccggtgc tttaccgcga acagctcatt acattggtag gtaacgtgcg cggtcgcagc      960

gccatcatcc ttgatgatat gatcgatcgc cctggctctt ttatctccgc ggctgaacac     1020

ttggttcaga actgtggcgc aaagaaggtg tacgttgtgg ccacccacgg catttttacc     1080

ggtgattgtt tggaagagct cgagaagtcc gatgccatcg acactattgt ggttaccaac     1140

acctacccaa tttctggaga gcgcattgct ggtagcaaaa agctggttac catcgatgtt     1200

agccccatct tcgccgagtg cattcgtcgc gaccactatg gcgagtccat tagcgtgctt     1260

ttcgacagcc tggcggccct g                                               1281


<210>  111
<211>  2040
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  111
atgactcagt ttactgatat cgacaagctg gcagtttcta ccatccgcat cctggcggtc       60

gacaccgtct caaaggcaaa ctccggccac cctggtgcgc ctctgggtat ggctccagcg      120

gcccacgtcc tttggtcaca gatgcgaatg aatccaacga atcctgattg gatcaaccgc      180

gaccgcttcg ttctctccaa tggacacgca gttgctttgc tgtactcaat gcttcatctc      240

accggttacg atctgagcat tgaagatttg aagcaattcc gccagctggg ttcccgcacc      300

cccggtcacc ctgagttcga attgcccggc gttgaagtta cgaccggccc acttggacaa      360

ggtatttcca acgcagtcgg aatggctatg gcgcaggcga atctggcagc gacctacaac      420

aaaccgggtt ttacactctc cgacaattac acttacgttt tcctgggcga cggatgcctg      480

caagaaggca tctccagcga ggcgtcctcc ttggcgggcc acctcaaact gggtaacctg      540

attgcaatct atgacgataa caaaatcact attgacggcg ccacttccat ctctttcgac      600

gaggatgttg caaagcgcta cgaggcatac ggttgggaag tactgtacgt cgagaatgga      660

aacgaagatc tcgcaggcat cgcgaaagct atcgcccaag ccaagctgtc caaggataag      720

cccactctga ttaaaatgac gaccaccatt ggatacggct ccttgcacgc gggttcacac      780

tctgttcatg gtgctccttt gaaagccgat gatgttaagc aactcaaatc taagtttggc      840

ttcaatcctg ataagtcatt cgttgttcca caggaagtgt acgaccacta tcagaagacc      900

atcctcaaac ccggagttga agccaacaac aagtggaata agctcttcag cgaataccag      960

aagaagtttc ccgagctggg agcggaactt gcccgtcgtc tcagcggtca actgcctgcc     1020

aattgggaat ccaagctgcc cacgtacact gccaaggaca gcgccgttgc gacccgtaaa     1080

ctgtccgaaa ccgtcttgga ggacgtctac aaccaattgc ctgagctgat cggtggctcc     1140

gcggatctta caccgagcaa tttgacccgc tggaaggaag cgctcgattt tcagcctccc     1200

tcgtctggca gcggcaacta ctccggccgc tacatccgtt acggtatccg cgagcacgcc     1260

atgggcgcca tcatgaacgg aatcagcgca ttcggtgcca attacaagcc ttacggtggc     1320

acgttcctga atttcgtgag ctatgccgct ggtgcagttc gtttgtctgc actgtccggt     1380

cacccggtca tctgggtggc aactcacgac tctattggcg ttggagagga cggtccgacc     1440

catcaaccga tcgagactct ggcccacttc cgaagcctcc ccaacattca ggtctggcgc     1500

ccagccgacg gaaacgaggt ctctgcagcc tacaagaaca gccttgagtc caagcacacc     1560

cctagcatca tcgcgctctc tcgccagaat ctgccacagc tcgagggctc ctctatcgaa     1620

tccgcgtcca agggcggtta cgttttgcag gatgtggcaa atccggacat cattttggta     1680

gcaaccggct ccgaagtctc cctgtcagtg gaggccgcaa aaacactcgc ggcaaagaac     1740

atcaaggctc gagtggtctc gcttcccgat ttctttacct tcgataaaca gcccctggag     1800

taccgtttgt ctgtgttgcc agacaacgtg cccatcatgt cagtcgaggt actcgcaacc     1860

acgtgttggg gtaaatacgc gcaccagtcc ttcggcatcg atcgcttcgg agcgagcggc     1920

aaggcacccg aggtctttaa gttttttgga tttaccccag aaggagttgc agagcgtgcg     1980

caaaaaacca ttgcattcta taagggtgac aagctgatct cgccgctcaa gaaggcgttc     2040


<210>  112
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  112
atgccgcgca acccgcttaa gaaggagtac tgggctgacg tggtcgatgg tttcaagcca       60

gccacctctc ctgcgttcga aaacgaaaag gaaagcacca ccttcgtgac agaactgact      120

tcaaagaccg actctgcgtt ccctctgtca tcaaaagata gccctggaat caaccaaacc      180

actaacgata tcaccagctc agaccgtttc cgccgaaacg aggataccga gcaggaggat      240

atcaataaca ccaacctctc gaaagatctg tcggttcgcc acctgttgac gttggcggtg      300

ggaggcgcta tcggcacagg tctctatgtg aataccggag ccgcgctttc taccggagga      360

ccagcttctt tggtcattga ctgggtcatc atttcaactt gtctgtttac tgtcatcaac      420

tccctgggtg agctgtcggc tgcgttccca gtggtgggag gatttaacgt ttactccatg      480

cgattcatcg agccctcatt tgcattcgcc gtgaatttga actacctggc gcagtggctg      540

gtgcttctgc cactggaact ggtggcagcg agcattacca tcaagtactg gaatgacaaa      600

atcaactctg atgcatgggt tgctatcttc tacgcaacca tcgcgctggc taacatgttg      660

gacgtgaagt catttggcga aaccgaattc gtgcttagca tgattaaaat tctgtcgatt      720

attggtttca ccatcctcgg catcgttctt tcatgcggag gtggccccca tggtggctac      780

attggcggca agtattggca tgaccccgga gctttcgtgg gccactcttc gggtacccag      840

ttcaagggcc tctgtagcgt ctttgtcacc gctgcattct cgtactctgg catcgaaatg      900

actgcggttt cggcagcaga aagcaaaaat cctcgcgaaa cgatcccaaa agcggcaaaa      960

cgcacattct ggttgattac cgcgagctac gttaccatct tgactctgat cggttgtctc     1020

gtaccaagca acgacccacg ccttcttaac ggtagctcat ccgttgacgc tgcatcctcc     1080

ccactggtaa tcgccattga aaacggcggc atcaagggct tgcccagcct tatgaatgct     1140

attatcctga tcgcggtcgt ctcggttgca aactcggcgg tgtacgcttg cagccgatgc     1200

atggttgcca tggcgcacat cggaaacttg cccaaattcc tgaatcgtgt ggataaacgc     1260

ggtcgtccta tgaatgccat tctgcttacc cttttcttcg gtctgctgtc ctttgtggcg     1320

gctagcgaca aacaagccga ggtgtttacc tggctttctg ccctgtccgg cctctccact     1380

atcttctgtt ggatggcaat caacttgtct catatccgct tccgtcaggc catgaaagtg     1440

caagagcgct ctctcgacga actgccgttc atctctcaga ccggcgtgaa aggctcctgg     1500

tacggattca tcgtgttgtt cctggtactt attgcatctt tttggacctc cctcttcccg     1560

ttgggaggca gcggcgcgtc ggcagagtcc ttcttcgaag gttacctttc cttccccatc     1620

cttatcgtct gctatgtggg ccacaaactt tacacccgta actggactct catggttaaa     1680

ttggaggata tggatttgga cactggccga aaacaagttg acttgactct ccgtcgcgag     1740

gaaatgcgta tcgagcgcga gaccctggca aagcgctctt ttgttacgcg atttctccac     1800

ttctggtgc                                                             1809


<210>  113
<211>  2397
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  113
atggtgctcc caattctgcc tctgattgac gacttggcct cttggaactc taagaaggag       60

tacgtctctc ttgttggtca agttctcctg gacggatcca gcctgtccaa cgaggaaatc      120

ttgcaattct ctaaggaaga ggaggtgccg cttgtcgcgc tttccctgcc ttcgggtaag      180

ttctctgatg atgagatcat cgcgttcctc aacaacggag tatcctccct gttcatcgcc      240

tcccaggacg ctaagactgc tgagcatctt gtcgaacaac tgaacgttcc aaaggaacgt      300

gtggttgtag aagaaaacgg tgttttctcc aaccagttca tggtaaagca aaaattctcc      360

caagacaaaa ttgtttccat taagaagctg tccaaagata tgttgaccaa agaagtactg      420

ggcgaagtcc gtactgaccg cccagacgga ctctatacca ctctcgtcgt tgatcagtac      480

gaacgctgtt tgggtctggt gtattcctcc aagaaatcca tcgcaaaagc tatcgatttg      540

ggacgcggtg tctactattc gcgatcccgc aacgagattt ggattaaggg cgagacatcc      600

ggtaatggcc agaaacttct gcagatttca accgattgcg atagcgacgc tctcaaattt      660

attgtggagc aggaaaacgt cggcttttgc cacttggaaa ccatgtcatg tttcggtgaa      720

tttaagcacg gattggtcgg tctcgaatca ctcctgaagc aacgtctcca ggacgctcca      780

gaggaaagct atacacgacg cctgtttaat gactccgctc tgctggacgc aaagatcaaa      840

gaggaagccg aggagttgac agaagctaag ggaaagaaag aactctcttg ggaagcagcg      900

gacctttttt acttcgccct cgccaagctc gtcgccaacg acgtctcgct caaagatgtc      960

gaaaacaacc ttaacatgaa gcaccttaag gtgacccgtc gcaagggaga cgcaaaacca     1020

aaattcgtgg gccaaccgaa ggcagaggaa gaaaagctta ctggtcctat tcatctcgac     1080

gtggtgaagg cctccgacaa agttggtgtt cagaaggcac tgagccgccc aattcaaaaa     1140

acctccgaaa tcatgcacct cgttaaccca attatcgaaa atgttcgcga taaaggaaat     1200

agcgcactgc ttgaatatac cgagaagttc gatggtgtga agttgtcaaa ccctgtactg     1260

aacgccccat tcccagagga atacttcgaa ggacttactg aggagatgaa ggaagcactc     1320

gacctctcca tcgaaaacgt gcgcaagttc cacgccgccc agctgccgac ggaaacactg     1380

gaagtggaga cccagccggg cgttctgtgt tcgcgtttcc cacgcccgat tgagaaggtt     1440

ggcctttata tcccaggtgg cactgctatt ctgccctcaa ccgctttgat gttgggagtt     1500

ccggctcaag tggcgcagtg caaggagatc gtgttcgcct cccctccacg caagtccgat     1560

ggcaaggtct ccccagaagt ggtgtacgtt gctgaaaagg ttggcgcgag caaaatcgtg     1620

ctcgcgggcg gtgcacaagc agttgcagca atggcttacg gcaccgaaac catccccaag     1680

gttgataaga tccttggtcc aggtaatcaa ttcgtaaccg cggccaaaat gtacgttcag     1740

aacgataccc aggctctctg cagcatcgat atgcccgctg gtccgtcaga ggttctggtg     1800

atcgccgatg aagacgccga tgttgacttt gtggcctccg acctcctcag ccaggcggag     1860

cacggtattg atagccaagt aatcctcgtt ggtgttaacc tttcggagaa aaagattcaa     1920

gaaatccagg acgcggtgca caatcaagct ctgcagcttc cccgcgtgga tattgtgcgc     1980

aagtgcatcg cacactccac catcgttctg tgcgatggat atgaggaagc tttggagatg     2040

tcgaatcagt atgcaccaga acacctgatt ctccagattg caaacgctaa tgactacgtc     2100

aaactcgttg ataacgcagg ttctgtgttt gtaggtgcct acacccctga gtcctgcgga     2160

gattactcca gcggtacaaa ccacaccctg cccacctacg gttatgcgcg tcagtactct     2220

ggagcgaaca ctgccacctt tcaaaaattc atcacggctc aaaacatcac cccagaaggc     2280

ctggagaata tcggtcgagc tgtgatgtgc gttgcaaaga aagaaggcct cgatggtcac     2340

cgcaacgctg ttaaaatccg tatgtcaaag ctgggactga ttccgaagga cttccag        2397


<210>  114
<211>  1155
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  114
atggtgttcg acctcaaacg catcgttcgc cctaaaattt acaatctcga accatatcgc       60

tgtgctcgcg atgatttcac cgaaggcatc ctcctcgacg caaacgagaa cgcccacggt      120

cctacgcctg tagagttgtc taagaccaac ctgcatcgct acccggaccc acatcaactc      180

gagtttaaga ccgctatgac taagtaccgc aataagacca gcagctacgc gaacgacccc      240

gaggtgaagc cactcaccgc cgataacctg tgcctgggtg tgggttctga tgaatccatt      300

gatgcgatca tccgagcttg ctgcgtgcca ggtaaggaaa agatccttgt acttccgccc      360

acgtactcca tgtattcagt ctgtgcaaat atcaacgata ttgaagtcgt acagtgtccc      420

cttacggtct ctgatggctc tttccagatg gacaccgagg cggtcttgac catcctgaag      480

aacgattccc ttatcaagtt gatgtttgtg acctcaccag gaaacccaac tggtgccaaa      540

atcaaaacct ccctcatcga aaaggtcctc caaaactggg acaacggcct ggtcgtcgtc      600

gatgaagcct acgtggactt ctgtggtggc tcgaccgcgc cccttgttac gaagtacccc      660

aacctcgtga cactccagac cttgagcaag tcctttggat tggccggtat ccgccttggt      720

atgacttatg caactgccga gctggctcgc attttgaacg ctatgaaagc accgtacaac      780

attagctcct tggcgtcaga gtacgcattg aaggcggtgc aggactccaa cttgaagaaa      840

atggaagcta cgagcaagat tatcaacgaa gaaaaaatgc gtcttttgaa ggagctgaca      900

gcgcttgact atgtggatga tcagtatgtc ggcggtctgg atgcaaactt tttgctcatt      960

cgcatcaacg gcggtgacaa tgtcctggca aagaagctgt actaccaact cgcaacccaa     1020

tcaggcgtgg tggttcgttt tcgcggcaac gagttgggct gttcaggatg ccttcgcatt     1080

accgttggta cacacgagga aaatacacac ttgatcaagt actttaaaga aacgttgtac     1140

aagttggcaa acgag                                                      1155


<210>  115
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  115
atggacctgg taaaccatct cactgatcgc cttcttttcg ccatcccaaa gaagggtcgc       60

ctgtactcta aatcggtatc catccttaac ggtgctgata tcacctttca ccgttcacag      120

cgcctggata ttgccctttc tacttctctc cccgtggcct tggtgttctt gccagcggcc      180

gacatcccaa cttttgttgg cgagggcaag tgtgatctgg gcattactgg cgttgaccag      240

gttcgtgaaa gcaacgtcga tgttgatctg gctattgacc tgcaattcgg caactgcaag      300

ctccaagtgc aggttcctgt taatggtgag tacaagaaac ccgaacagct cattggcaaa      360

accattgtta cctcctttgt taaactggct gagaagtatt tcgcggattt ggagggtacc      420

accgttgaaa aaatgacaac gcgcatcaag ttcgtgagcg gctcggttga ggcctcttgt      480

gctcttggca ttggagatgc tattgtcgac ttggtcgaat ccggcgaaac gatgcgtgca      540

gcaggtctgg ttgatatcgc gaccgtcctg tcaacctccg cctacctgat cgagtcgaaa      600

aaccccaaga gcgacaaatc ccttatcgca acgattaaat cccgtatcga aggagttatg      660

actgcacaac gcttcgtttc ttgtatttat aatgccccag aggacaaatt gcccgaactc      720

ctgaaggtga ctccaggtcg tcgcgccccc accatttcca agattgacga tgagggttgg      780

gttgccgttt cctctatgat cgagcgcaag accaagggcg tagtcctcga tgaactcaaa      840

cgactgggcg catctgatat catggtattc gaaatctcta actgccgagt g               891


<210>  116
<211>  783
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  116
atgacgaaat tcatcggatg catcgacctt cacaatggcg aggttaagca gattgtcggc       60

ggtacactga catccaagaa ggaagatgtc cctaagacta acttcgtttc ccaacatccg      120

tcttcttact atgcgaagct ttacaaagat cgcgatgtac agggctgtca cgttatcaag      180

cttggtccta acaatgatga tgctgcccgc gaagctcttc aggaatctcc ccagtttctt      240

caagtcggtg gtggaattaa cgataccaac tgcttggaat ggctcaagtg ggcttccaaa      300

gtcattgtaa cctcctggct ctttaccaag gagggacatt ttcaattgaa gcgcctggaa      360

cgtcttacgg agctttgtgg aaaggaccgc atcgttgtgg acctctcctg tcgtaaaact      420

caggacggcc gctggattgt agccatgaac aagtggcaga cccttaccga tctcgagctt      480

aacgccgata ctttccgcga actgcgcaaa tacactaacg aattcttgat tcacgcagca      540

gatgtcgaag gattgtgtgg cggaatcgac gaactgctcg tgtccaagtt gttcgagtgg      600

acaaaagact acgatgattt gaagattgtt tacgccggag gcgccaagtc tgtggacgat      660

cttaaacttg tggacgagct ctctcacggc aaagtggacc tcacgttcgg atcgtccctt      720

gatattttcg gtggcaacct ggttaaattt gaggactgct gccgttggaa cgagaagcaa      780

ggc                                                                    783


<210>  117
<211>  1656
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  117
atgcctgttg tgcacgtgat tgacgtggaa tctggcaatt tgcagtccct caccaatgca       60

atcgagcacc tcggttacga agtccagctt gtaaagtccc ccaaggattt taacatttcg      120

ggtacctccc gacttatctt gcccggcgtt ggtaattacg gacatttcgt cgacaatctt      180

tttaaccgag gttttgaaaa gccgattcgt gaatacatcg aatcgggcaa gcccattatg      240

ggcatttgtg tgggcctgca ggcccttttc gcgggttccg tcgaatcccc taagtccacc      300

ggccttaatt acattgattt caaactgtct cgcttcgacg attccgaaaa gcccgttccg      360

gaaatcggct ggaacagctg catccccagc gagaatctgt tcttcggact cgatccatac      420

aagcgatact actttgtaca ttctttcgct gcgattctga attccgaaaa gaaaaagaac      480

ctggaaaacg acggttggaa gatcgcgaag gccaaatatg gctctgaaga attcattgcc      540

gccgtgaata agaacaacat ttttgcaacg cagttccatc cagaaaaatc tggtaaagcc      600

ggtcttaatg tgatcgagaa cttcttgaaa caacagtcac ccccaatccc caactactcc      660

gctgaggaaa aggaactttt gatgaacgac tatagcaact acggactcac ccgacgtatc      720

attgcatgcc ttgacgttcg caccaacgac cagggtgatt tggttgtcac caaaggtgac      780

caatatgatg ttcgcgagaa gtccgacggc aaaggcgtac gcaatctcgg taagcctgtt      840

caactggctc agaagtatta ccaacaaggc gccgacgagg taacgtttct gaatattact      900

tcatttcgcg actgccctct gaaggatacc cccatgctcg aagttttgaa gcaggccgca      960

aaaactgtgt tcgtaccgct gaccgtggga ggcggcatca aagacatcgt agatgtggat     1020

ggtaccaaga tcccagcact cgaggttgct tccctttact ttcgatctgg tgcagacaag     1080

gtttcaattg gcacggacgc tgtctacgct gccgagaagt attatgagtt gggtaaccgc     1140

ggcgacggca catcgccaat tgagacgatc agcaaagcct acggtgcaca ggcagttgtc     1200

atctctgtag acccaaaacg cgtgtatgtc aattctcagg ctgacactaa gaacaaggtc     1260

tttgagactg aatacccagg tcccaacggt gaaaaatatt gctggtacca gtgcacgatc     1320

aaaggaggcc gcgagtcccg tgatcttggc gtgtgggaat tgactcgcgc atgtgaggca     1380

ttgggtgccg gcgaaatcct tcttaactgt atcgacaagg acggctcgaa ctccggttac     1440

gatctcgaac tcatcgaaca cgtgaaggat gccgttaaga ttcccgtgat tgccagctcc     1500

ggcgcaggag tgcctgaaca cttcgaggaa gccttcctga aaacccgcgc tgacgcatgc     1560

ttgggtgcgg gaatgtttca ccgtggcgaa ttcacagtca acgatgtaaa agaatatctt     1620

ctcgagcacg gccttaaggt tcgaatggac gaggaa                               1656


<210>  118
<211>  744
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  118
atggctcgta ccttcttcgt gggaggtaac ttcaagctca atggttctaa acagtcaatc       60

aaagagatcg tggaacgact caatactgcg tccatcccgg aaaacgtcga ggtcgtaatt      120

tgcccacccg ccacctatct tgattactcc gtctcccttg tgaagaaacc acaagttact      180

gttggcgcgc aaaacgccta tttgaaggct tccggtgcgt tcaccggaga gaattcagtg      240

gaccagatta aagatgtggg cgcaaaatgg gttatcctcg gacactcaga gcgccgctcg      300

tacttccacg aggacgacaa gttcatcgca gacaaaacta agtttgcact gggacagggc      360

gtaggcgtca tcctttgcat tggagaaacc ctggaggaaa aaaaggcagg caaaacactc      420

gacgttgtcg aacgccaact caacgccgtt ctggaagaag tgaaggattg gactaatgtg      480

gtggtggcat atgaaccagt ctgggccgtg ggtaccggcc tggcggcgac ccccgaagat      540

gcgcaggaca ttcacgcgag catccgtaaa tttctggcct ctaagctggg tgataaggcc      600

gcttccgagc tccgcattct ttacggtggt tcagccaacg gctcgaacgc tgtgaccttt      660

aaggacaagg ccgacgtcga tggattcttg gtcggcggtg catctcttaa accagagttc      720

gttgacatca tcaacagccg caac                                             744


<210>  119
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  119
atgctgaaga tcgcagtgcc aaacaagggt tcgctttccg aacgagctat ggagatcctg       60

gcggaagctg gttacgccgg ccgtggagat tccaagagcc tgaatgtgtt cgatgaggcc      120

aacaacgttg aatttttctt tttgcgacca aaggacatcg cgatctatgt tgcaggtggt      180

caactggacc tgggtatcac cggtcgagat ctggcacgtg attcccaagc cgatgtgcac      240

gaagttctgt cgttgggctt cggctcttcc acgtttcgct atgccgctcc agctgatgaa      300

gaatggtcga tcgaaaaact cgatggaaag cgcatcgcga cctcatatcc aaaccttgtc      360

cgcgatgacc tggcagcacg cggattgtcg gccgaagtcc tccgtctgga tggcgcggta      420

gaagtcagca ttaagcttgg tgttgccgat gcaattgctg atgtggtgtc cacaggccgc      480

accctgcgcc aacagggcct cgcgcctttc ggagaagttc tgtgcacctc tgaagccgtg      540

atcgtgggcc gcaaagatga aaaggttact ccggaacaac agatcctttt gcgacgcatc      600

caaggcattc tccacgcaca gaacttcctc atgttggatt acaacgtgga ccgagataac      660

ctggatgctg caaccgcggt caccccaggc ctttctggtc ccaccgtctc cccgctcgcc      720

cgcgacaact gggtggcggt tcgtgcaatg gtaccgcgcc gatccgccaa cgcgatcatg      780

gataaactgg ccggcctcgg cgcggaggca attttggctt ctgaaattcg tatcgcacgc      840

atc                                                                    843


<210>  120
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  120
atgcttaaga ttgcagtgcc gaataaaggc tccctgtcgg agcgagctat ggaaattctg       60

gcggaagcgg gttacgcggg tcgcggtgat tctaagtccc tgaacgtctt cgatgaagcg      120

aacaacgttg aatttttttt tttgcgcccg aaggacattg caatctacgt agcgggaggt      180

cagctcgatc tgggtattac cggccgcgac ctggcacgtg attcacaggc tgatgtgcac      240

gaagtgctga gccttggctt cggctcctca acattccgct atgcggcacc agccgatgaa      300

gagtggtcga ttgaaaaact cgatggtaaa cgtatcgcaa cctcctatcc caacctggtc      360

cgtgatgatc ttgcggcgcg cggattgtcc gctgaagttc tccgactcga tggcgcggtc      420

gaggtatcca tcaagctggg cgtagcggat gcaatcgctg atgtcgtgag cactggccgt      480

accctccgcc agcaaggatt ggctccattc ggcgaggttc tctgtacttc ggaagctgtt      540

attgtgggcc gcaaggacga gaaagtgact ccagaacagc aaatcctcct gcgccgcatc      600

cagggtatcc tccatgccca aaactttttg atgcttgatt ataaggtgga ccgagataac      660

ctcgacgccg ccacggccgt gactccaggc ttttctggac ctgctgtttc gccgcttgca      720

cgtgataact gggttgcggt acgtgccatg gttcctcgtc gttctgccaa cgccattatg      780

gataagctcg caggcctcgg tgcggaagcg atcctcgctt ccgaaattcg cattgcgcgt      840

atc                                                                    843


<210>  121
<211>  948
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  121
atgtccgaat tcgacaagaa acttaacacc ctcggagtgg accgaatctc ggtatcaccc       60

tataagaaat ggtcccgtgg ttacctggaa ccgggtaacg ttggcaacgg ttacgtctcc      120

ggtctcaaag tcgacgcagg cgtgatcgat aaaacagatg acatgattct cgacggtatc      180

gtgtcgtatg atcgcgcgga gaccaaaaac gcctacatcg gccagattaa tatgactacc      240

gcgtcctcat tttctggagt gggcggcacc gttctgggct atgatatcct tcgaaatccc      300

gaggtcgata aagcgaaacc tctctttact gaaaaacagt gggatggttc cgagcttcct      360

atttatgacg cgaaaccact gcaggacacc ctggtggaat actttggcac caaagatgat      420

atgcgccatt accccgcacc gggcgcgttc gtttgctgcg caaataaagg agtgaccgcg      480

gaacgcccta aaaacgacgc cgatatgaaa ccgggacaag gctacggagt gtggagcgct      540

atcgctatca gcttcgcgaa agatcccaca aagtactcgt ccatgtacgt ggaagatgcc      600

ggtgtctggg aaacccctaa tgaggatgag ttgatcgaat acctgaaggg ccgacgcaat      660

gccatggcaa agtctatcgc cgcgtgcggt gagaacacag cagcagagaa cggcggagcc      720

gttttcacct caagctggat cggattcgct catgcaatga tgaaaccagg ccaggtcgga      780

aacgcgatta ccgtggcccc gtatatcgcc atgccagtgg actcaattcc aggcggttca      840

attcttacgc cagatactga catggatatt atgcagaatt tgacgatgcc tgagtggctc      900

gataagatgg gataccagcc cctcacgaag ggaggaaaca tcaactat                   948


<210>  122
<211>  849
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  122
atggaaccag gcaacatcgg aaacggttat gtcaccggtt tgaaggtaga cgctggcgtt       60

cgcgacaaga ccgatgacga cgtgctggat ggaatcgtct catacgatcg tgctgaaact      120

aagaacgcat acatcggcca aatcaacatg accacggcaa gctccttcac gggcccgcag      180

ggccacgttg tgggatatga catcctgcga aatcctgagg tggacaaggt aaagccgctt      240

ttcgtggaaa agcaatggga tggctcggac ctgccaattt acgatgcaaa gccgcttcag      300

gacgccctgg tcgaatattt cggcatggag caggaacgcc gccactaccc agcaccgggc      360

tctttcatcg tttgcgccaa caaaggtgtc acggcggagc gccctaaagc tgacgagcca      420

cttaagccgg gtcagggcta cggcgtgtgg tccgccatcg ctatctcttt cgctaaggac      480

ccgtcgaaaa actcatccat gttcattgaa gacgcgggcg tgtgggaaac ccctaacgag      540

gatgagctca tcgagtatct gaatggccgc cgcaaggcaa tcgctaaatc tatcgctgag      600

tgcggtcagg acgctgatac cgctttcgaa tcttcctgga tcggctttgc ccatgttatg      660

atgaagcctg gtcagatcgg caatgcgatc accgttggac cgtacttttc gcttccggtg      720

gattccatcc ctaacggttc gattctgacc cctgataagg atatggagat catggagaac      780

ctttccctcc cggagtggct cgacaaaatg ggctatgagt cccttgtgaa gaagaataat      840

gtgacatac                                                              849


<210>  123
<211>  1212
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  123
atgaccctct cgccagcgga tcagcgcaag cttgaaggtt tttggcagca ctgcgttacc       60

caccagtact ttaatattgg ataccccgaa tctgccgact tcgactattc ccagctgcac      120

cgattccttc agttctccat caataactgc ggagattgga atgaatactc taactacttg      180

ttgaactctt tcgacttcga gaaggacgtc atgacgtatt ttgcagaact cttcaatatc      240

gcactggagg actcctgggg ctacgtgaca aacggcggta ccgagggaaa catgttcggc      300

tgctacttgg gccgcgaact cttcccagat ggaacccttt actactcaaa ggacactcac      360

tactcggtgg ctaagattgt caagctcctc cgcatcaagt gtcgtgcagt tgaatctctc      420

ccaaacggag agatcgacta tgatgatctg atggctaaga tcaccgctga tcaggagcgc      480

cacccgatca ttttcgcgaa tattggtaca acgatgcgcg gcgctgtgga caatattgta      540

acgatccagc aacgccttca acaagctggc atcgcgcgcc acgattatta cctgcatgca      600

gatgctgccc tttccggcat gatcttgcct ttcgtggacc atccccagcc cttctcgttc      660

gctgacggca ttgactctat ctgtgtgtcc ggccacaaga tgatcggctc cccaattcca      720

tgcggcatcg tagttgcaaa acgcaataac gtcgctcgca ttagcgtcga agtcgactac      780

atccgtgcac acgacaagac aatttccgga tcgcgtaacg gccacactcc cctgatgatg      840

tgggcggcgc ttcgttctta ctcctgggca gaatggcgac atcgcattaa acactctctt      900

gatactgcgc agtacgcagt ggatcgattt caggcatcgg gtattgatgc gtggcgcaac      960

gaaaactcga tcaccgtcgt tttcccatgt ccatccgaac gtattgcgac caaatactgc     1020

ttggctactt ctggcaatag cgcccacctc atcacgaccc cgcaccatca cgactgttcc     1080

atgatcgacg cgcttatcga tgaagtcgtc gccgaggcac agctgaatac tctgcgctcc     1140

aaacgtgcgt tcacggacca gactgtggtt gagcgtctgc cagcggcaag ctttaacttg     1200

cgcacccatt ac                                                         1212


<210>  124
<211>  1224
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  124
atgactttgt ctacggcaga cactcatcgt cttgatgact tttggcagca ctgtctcaag       60

caccagtttt tcaacattgg atatcctgaa aacgccgatt ttgactattc cgcgctggag      120

cgtttcctgc gattctccat caataactgc ggagactggt cggagcactc caactacgta      180

ttgaactcct ttgatttcga gaaagaagtc atggcttact ttgcagactt gtttgagatt      240

ccacgtgaag actcatgggg ctacgtgact aacggcggaa ccgaaggcaa catgttcggt      300

tgttatctcg ctcgcgaact gttccctgat ggtaccctct actactcaaa ggatacccac      360

tactctgtag ctaagatcgt aaagcttctc cgcatcaagt gccgcgctgt gaacgctctg      420

ccaaccggcg aaatcgatta cgacgacctg ctcgccaaga tcgcggccga cggtgagcgc      480

catccaatta tctttgcaaa cattggcact actatgcgcg gcgcagttga cgatatcgcc      540

gttattcaac agcgcttgca ggacgcaggc attgcgcgcc gcgattatta cttgcacgct      600

gatgcggcac tgtccggtat gattctccca ttcgtcgacg caccacagcc tttcactttc      660

gccgacggta tcgattccat ctgcgtctcc ggccacaaga tgatcggttc cccgatccca      720

tgtggtatcg ttgtggctaa gcgtcgcaat gtagcccgaa tctccgtgga ggtggactat      780

atctccgcct ccgataaaac tatctccggt tcgcgcaacg gccatacccc catgattatg      840

tgggcagcat tgcgtagcca ctcgtccgcg cagtggcgac gccgcgtcga gcgttccctg      900

gcggccgcac agtacgcggt gaaccgcctg caggccggcg gtgtcaaggc ttggcgtaac      960

cctaacagca tcacggtggt cttcccctgt ccgtcggcag atatcgctcg aaagtacggc     1020

ttggctactt ccggtgacac cgctcatctc attaccaccc cacatcatcg cgataatcgc     1080

gctattgacg ctctgatcga tgaagttatc gcggatgcgc gccccgaggt ctggcgagca     1140

acattgcaac gctcgtggca gggttccgct cagcgcttgc cacgaaccgc atcctggaac     1200

caggcggccg gactgggccg cttt                                            1224


<210>  125
<211>  1281
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  125
atgacatttt cgccagcaga ccacaaacgc cttgaggctt tctggcagta ttgtcttacc       60

caccagtatt tcaacgtggg ctatccggaa tccgcagact tcgactactc actccttcac      120

cgcttcatgc gtttttccat caataactgc ggcgattgga acgaacccag caactacttg      180

cttaacagct tcgattttga acgcgaagtt atgcgatttt ttgcggaact ctttcacatc      240

ccctttgaag actcgtgggg ctacgtgacc aacggaggaa ccgagggaaa tatgttcgga      300

tgttaccttg cgcgcgaact ttttccggac gcaaccctct actactccaa agatacgcac      360

tactccgtcg ctaagatcgt ccgtctcctg cgcatcaagg cacaggtcgt ggaatcacaa      420

gcaaacggag agatggacta tgatgatctt gtggcccgta ttgcagccga cggcgaacgt      480

caccccatca tcttcgccaa tattggtacc acgctgcgcg gtgccaccga taatattgcg      540

gtcatccaac aacgtctggc tcaagccggc atccgtcgcg aggattacta cttgcacgcc      600

gatgccgcac tgtcgggcat gatcttgcca tttgtggatg ctccagaacc atattcattt      660

gcggatggca ttgactccat ctgtgtgtcg ggacacaaga tgattggctc tccaatgcct      720

tgcggcatcg tcgttgctcg tcgccacaat gtagaacgaa tctccgtgga aatcgactac      780

atctcagcac gagatcagac catttcaggt agccgcaacg gtcacactcc acttatgatg      840

tgggctgcct tgtgctcccg ctctcgcgag gactggcgcg cccgtatcca gcgttgtctc      900

gatttggcgc aacacgcggt ggatcgcctg cgtgcagctg gcatcgaggc atggcgcaac      960

ccaaactcca tcaccgtcgt ttttccatgc ccctctgcct cggtctggaa gcgccattgc     1020

ctcgcaacca gcggcgatac cgcacacttg atcactactg ctcatcatca ggattccacc     1080

cagatcgatg cactgttgga tgagttgatt gccgacttga aggcgcgcac ccgctaccct     1140

ttgcaggccc ccctggtcga aggtctgggt tcacgaacgc gcgtgtattc cactgcaggc     1200

cagccgcgcc cggagccact ccctgatcac gcacgccccg cgcgcgattc aggacttgca     1260

cgtctgaaag actccgaaat c                                               1281


<210>  126
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  126
atgtcgctga gcccgcttga ccaaaaccgc attgaaagct tctggcagta ttgccttcag       60

catcagtatt tcaaccttgc ctatcctgaa tccgccgact ttgactatgc cccccttcac      120

cgtttcttgc gattctctat caataactgc ggtgattgga acgagtcctc caactacctc      180

ctcaattcgt tcgacttcga gcgcgaagtg atgcacttct tcgcggaatt gtttcacatt      240

ccatttgatg agagctgggg ttatgtcacc aacggcggaa ccgagggcaa catgttcggt      300

tgttacctgg cccgcgaatt gtttccagat gcaacattgt actattcgaa agattcacac      360

tactcggtcg ctaagatcat taagctgctg cgtattaagt ctcgtgccgt ggactccctc      420

ccatccggtg agatcgatta cgacgatctt gtcgcaaaaa tccaacagga tcaggaacgc      480

catcccattg tttttgttaa tgtaggtact accatgaagg gagcagtcga tgacatcggc      540

gtgatccagc ataaactcgc tgaagcggga attccccgtc aggactacta cctccacgcg      600

gacgcagcat tgtcgggtat gatcttgccc ttcgttgacg cgcctcagcc gtactcattc      660

gcagacggaa ttgattccat tagcgtgtcc ggccacaaga tgatcggctc tccaatgccc      720

tgcggcatcg tactggcaaa gcgctcgaat gtctctcgca tttctgttga gattgattat      780

atctcggcca aggatcaaac catctccggc tctcgtaacg gccacactcc aatgatgttg      840

tgggcggcaa tcaagtcccg tccgctcgcg gaatggcgcc gcaaggtccg ccactgtctc      900

gacatggcgc agtacgcgat tgatcgactc caggcggcag gtatccaggc atggcgctgc      960

aagaactcga ttactgtcgt tttcccatct ccttcagaac ccgtttgtga taaacacgga     1020

cttgctcgca gcggcggtac ggcgcacctc atcacgaccc cacatcacca tgatagccaa     1080

cgccttgacc gccttctgga tgacatcgtt caggatctcg gtgcaatgac tgctccggct     1140

ggagctacaa tgtctgccgc g                                               1161


<210>  127
<211>  1134
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  127
atgaccttgt ccattgttga tcagaataag ctggacgctt tctggtctta ctgtgttaag       60

aaccaatact tcaacatcgg ttatccggaa agcgccgatt ttgattatac catcctcgaa      120

cgtttcatgc gcttcagcat caacaactgc ggtgattggg gcgagtattg taactacctg      180

ctgaactcct tcgacttcga aaaagaagta atggaatatt tcgcccgtat ctttaagatt      240

cctttcgaag agtcgtgggg ctatgttacc aatggtggca ccgaaggcaa catgtttggc      300

tgttacttgg gccgtgaatt gttccctgaa ggaactcttt actattccaa ggacacgcac      360

tatagcgttg cgaaaattgt gaagttgctt cgcattaaat cctccctcgt agaatcgcaa      420

ccaaatggag aaatggatta cgacgatttg atccgcaaaa ttcaacgcga taatgaagaa      480

catcccatca tcttcgctaa cattggcacc accgttcgtg gagctatcga caacattgca      540

gaaattcaac aacgcattgg acagttggga atcaaacgag acgactacta tttgcacgcc      600

gatgctgccc tgagcggaat gattttgcca tttgtcaacg acccacaacc atttaatttt      660

gcagacggca tcgacagcat tggtgtgtca ggacacaaga tgatcggttc ccctattcca      720

tgtggcatcg tcgttgctaa acgtaagaac gtggatcgaa tctccgtcga gatcgattac      780

atttccgcgc atgataaaac catctccggc tctcgcaatg gtcatacacc actgatgatg      840

tgggaagcta tccgctcgca ctcttggagc gattggcagc gccgcatcga gcactcgctc      900

aacatggccc aatacgccgt ggatcgcctc caagctgctg gtatcgacgc atggcgtaac      960

aagaatagca tcaccgtcgt gtttccatgt ccgtccgaag cagtgtggaa gaagcactgc     1020

ttggctacga gcggcgatat cgctcatctt atcacaactg cacatcacct cgacagctct     1080

aagattgatg agttgattga cgacgttatt gctgatttga accagcaagc cgca           1134


<210>  128
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  128
atgagcctgt cctccttgga tcaaaaccgc attgaatctt tctggcaata ttgtctccag       60

caccagtatt ttaaccttgc ctatcccgaa tccgccgact tcgattacac cccgttgcat      120

cgctttttgc gattctcaat caacaattgt ggtgattgga acgaaagctc caactacctc      180

cttaactctt tcgatttcga gcgcgaagtc atgcacttct tcgcggaact cttccacatc      240

cccttcgacg agtcctgggg ctacgtgacg aacggtggca cggagggaaa catgtttggc      300

tgctaccttg cccgagagtt gttccccgat gctaccctct attacagcaa ggatagccac      360

tactctgtgg caaaaatcat caaactcctg cgcattaaga gccgcgcggt ggactctctt      420

ccctccggtg agatcgatta tgacgatctt gtcgccaaga tccagcaaga ccaagagcgt      480

catccaatcg ttttcgtcaa tgtgggcacg acaatgaagg gtgctgtgga cgacattggt      540

atcattcagg ataaactggc acaggcgggc attccgcgtc gcgattacta cctgcatgct      600

gacgcggcac tcagcggtat gatcctccca tttgtagacg cacctcaacc ttattctttt      660

gcagatggca tcgactccat ctccgtcagc ggtcacaaga tgatcggctc ccccatgcca      720

tgtggcattg tcttggcaaa acgttccaat gtatcgcgca tctccgtgga gatcgattac      780

atctctgccc gcgatcagac aatctctggc tcccgtaacg gacacacccc gatgatgctg      840

tgggcagcaa tcaaatctcg ccccttggca gaatggcgcc gtaaagtacg ccactgtctg      900

gatatggctc agtacgccat cgaccgcttc cgcgccgcag gcattcaggc ttggcgctgt      960

caaaattcaa tcaccgtcgt cttcccatcg ccctccgagc ccgtctgcga taagcacggt     1020

ctcgcgcgct ccggcggtgc cgcccacttg atcacaactc cacatcacca tgattcccag     1080

cgcctcgacc gtctcatcga cgatatcatt caggatctgg gtgcagtaac ggctcctgcc     1140

ggtgccgcta tgtccgcagc a                                               1161


<210>  129
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  129
atgtctgaat tggatgccaa actgaacaaa ttgggagtcg atcgcattgc gatttcccca       60

tacaaacagt ggactcgagg atatatggaa ccaggcaaca ttggtaacgg ttacgtcacc      120

ggcttgaagg ttgatgcagg cgttcgcgat aagagcgatg atgatgtgct cgacggtatc      180

gtgagctacg atcgtgcaga aaccaagaac gcctatatcg gacagattaa tatgactacc      240

gcgtcatcat tcactggtgt tcagggtcgc gtgatcggtt acgatattct gcgatccccg      300

gaagttgaca aggcaaagcc cttgttcaca gaaacccagt gggacggttc cgaactgccc      360

atctacgacg ccaaaccttt gcaagacgct cttgtcgagt attttggcac cgaacaggat      420

cgtcgacact accctgctcc gggttctttc attgtctgcg ctaataaagg tgtgaccgct      480

gagcgtccca aaaacgatgc ggatatgaaa ccaggtcaag gctatggtgt ctggtcggcc      540

attgcgattt cgtttgccaa ggacccaacg aaggactcgt ccatgttcgt tgaagatgca      600

ggtgtttggg aaacccccaa cgaggatgag ctgctcgagt accttgaagg ccgtcgaaaa      660

gctatggcga aatctatcgc ggaatgcgga caggatgctc acgcctcatt cgaatcttcg      720

tggatcggtt ttgcgtacac aatgatggaa ccaggtcaga tcggaaatgc tattacagtt      780

gcgccctacg tgtccttgcc tattgattca attcctggtg gttctatcct cactccggat      840

aaggatatgg agattatgga gaatctcacc atgcctgaat ggcttgagaa gatgggctac      900

aaatccttga gcgctaacaa tgctctcaaa tat                                   933


<210>  130
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  130
atgtccgagc ttgacactaa attgcacaag ttgggcgttg atcgcattgc aatttctcct       60

tataagcaat ggtcccgagg atacatggag cccggcaata ttggtaacgg ttacgtaacc      120

ggtttgaagg tggacgccgg cgtgcgcgac aagaccgacg atgaagttct cgacggaatt      180

gtgtcatacg atcgagcaga aacgaaaaac gcatacattg gccagatcaa catgacgacc      240

gcctcgtcct tcaccggccc acaaggacac tgcattggct acgatcttct ccgcaaccct      300

gaggtggaca ccgccgaacc tctcttcact gttaagcaat gggatggcag cgaattgccg      360

atttacgacg ccaaaccgct gcaggattct cttgtggagt atttcggcac caacaacaac      420

cgccgccact acccagcgcc tggctcgttc attgtttgcg caaacaaggg tgtaactgcc      480

gaacgcccaa tgaatgattc cgatatgaaa ccgggccagg gctacggagt gtggagcgca      540

attgcgcttt cctttgcgaa ggatccggca aaagactcct caatgtttat cgaagatgcg      600

ggcgtgtggg aaactccgaa tgaggacgag cttatcgagt atcttaaggg acgtcgtaag      660

gcgattgcaa aatccattgc agaatgcggt caagatgcca acacatcctt caaaggctct      720

tggatcggct ttgcccacgc catgatggaa ccgggccaga tcggaaacgc aattacagtt      780

gctccttata tttctatgcc ggtcgatagc attccaggcg gctcaatcct gactccggat      840

accgatatgg acattatgga aaatctcacc atgccagaat ggttggataa aatggagtac      900

aaatccctga ctgctaacgg tgcaatcaag tac                                   933


<210>  131
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  131
atgtccacta actcgatcaa actgctggct ggaaactcgc acccaggcct tgccgaactg       60

atctcgcagc gacttggcgt gccgctcagc aaagtcggcg tgtaccagta ctctaacaag      120

gagacctcag tcacaattgg cgaatccatt cgcgacgagg acgtttacat tatccaaacc      180

ggttacggtg agcatgaaat caacgatttt cttatggagc tcctgatcct gattcacgct      240

tgcaagacag ccagcgtgcg ccgtatcacc gcggtcatcc ctaactttcc gtacgcacgc      300

caagataaga aagataagtc ccgtgcgccg atcaccgcca aattgatcgc caacctcctg      360

gagacggccg gctgcgatca cgtgatcacc atggacttgc atgcatcgca gattcagggt      420

ttcttccaca tcccggttga caacctttac ggcgaaccgt cagtgctgaa ctacatccgc      480

acgaagaccg attttaataa cgcaattttg gtatcgcccg acgcaggcgg cgcgaaacgt      540

gttgcgtctt tggcagacaa gctggatatg aactttgctt tgatccacaa ggagcgccag      600

aaggcaaacg aggtctcccg catgctgctc gtcggtgatg tcgcgggcaa aagctgcctt      660

cttatcgacg atatggcaga cacatgtggt actctggtga aggcttgtga caccctgatg      720

gaccatggcg ccaaggaagt tattgcaatc gtgacccacg gcattttctc gggttcagct      780

cgcgagaaac tcattaattc gcgcctgtcc cgcattgtct gcacgaatac cgtaccggtg      840

gatctcgatc tcgacatcgt ggatcaggtc gatatctcac caacgattgc tgaagcaatt      900

cgccgtctcc acaacggcga atccgtttcg tacctcttca cgcatgcgcc agtc            954


<210>  132
<211>  960
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  132
atgcctacaa attcgatcaa gttgttggcg cccgatgttc accgcggtct tgcggagctg       60

gttgctaaac gcttgggact gcaacttact tcctcaaagc tgaagcgaga ccctaccggc      120

gaggtgtcct tcagcatcgg cgaatcagta cgcgaccagg atatcttcat catcactcaa      180

attggctccg gcgtggtgaa cgatcgtgtc ctggaactgc tgatcatgat caacgcctcg      240

aaaaccgcgt ccgcccgacg catcaccgcg atcatcccca attttccgta tgcgcgccag      300

gaccgcaagg ataagtcccg tgctccaatt accgctaaac ttatggcaga catgctgacc      360

accgcaggct gtgaccatgt tatcactatg gatctccacg cgtctcagat ccagggtttt      420

ttcgacgtgc cagtggataa tctgtacgcg gaaccatccg tcgtgcgcta tatcaaggaa      480

aacgtgaatt atatggattc cattatcatc agccccgatg cgggaggcgc caagcgcgcg      540

gcaaccctcg cggatcgcct ggatttgaat ttcgcactca tccacaagga gcgcgcgcgc      600

gctaatgaag tctcccgcat ggtgctcgtt ggcgatgtta ctgataagat ctgcattatc      660

gtagatgaca tggctgacac ttgtggaact ttggccaagg cagccgagat tctgctggaa      720

aaccgcgcga agtctgttat cgcgattgtc acccacggcg tcctttcggg tcgcgcaatt      780

gaaaatatca ataactccaa actcgatcgc gttgtgtgca ccaacacagt tccatttgaa      840

gaaaagatca aaaaatgccc caagctggct gtcatcgata ttagctctgt actggcagag      900

tccatccgcc gccttcacaa cggtgaatca atctcctatc tcttcaagaa ctatccgttg      960


<210>  133
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  133
atgtccgaac cagcccaaaa aaagcaaaag gttgctaaca attccctgga gcaactgaag       60

gcctctggta ctgttgtagt ggctgatact ggtgatttcg gttccatcgc caagtttcag      120

cctcaggatt ccactacaaa cccctccttg atccttgccg ccgctaagca accaacctac      180

gccaagctca tcgacgtcgc agttgaatac ggcaagaaac acggtaagac tacggaggag      240

caagtcgaga acgcggtcga ccgcctgttg gtggagttcg gcaaggagat ccttaaaatc      300

gttcccggcc gcgtctccac cgaagtcgat gcccgattgt cctttgatac ccaagccacg      360

atcgaaaagg cccgtcacat cattaagctc tttgagcagg aaggcgtttc caaagaacga      420

gtcctcatta agattgcgtc aacctgggaa ggcatccaag cagccaaaga gcttgaggag      480

aaggacggta ttcattgtaa tctgacgctg ctcttttctt tcgttcaggc tgtagcttgt      540

gcagaggcgc aggttactct catctcccca ttcgtaggtc gaatcctgga ttggtacaaa      600

tcttcaaccg gcaaggatta caagggcgag gctgaccctg gcgtcatctc cgtcaaaaag      660

atctataact actacaagaa gtatggctat aagaccatcg tcatgggcgc ctctttccgt      720

tccaccgatg aaattaaaaa ccttgctggc gttgactatc tgacgatttc ccccgcactc      780

ctggacaaac tgatgaattc aaccgaaccc tttccccgtg tcttggatcc tgtctcggcg      840

aaaaaggaag ccggcgataa aatttcatac atctctgacg agtctaagtt ccgttttgat      900

ctgaatgaag acgctatggc aaccgaaaaa ctgtcagaag gcatccgtaa gttctccgcc      960

gacatcgtta ccctttttga cctcattgaa aagaaagtga cagcc                     1005


<210>  134
<211>  1011
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  134
atgtctgaaa atgcagcaaa caacatcatg gaaactaaga tttgcaccga tgccatcgtg       60

tccgagcttc aaaagaaaaa ggtacatttg ttctactgcc tggaatgcga agaactcgct      120

cgaaatatcg cagccgagtc cgatcatatc acccttcaaa gcattaactg gcgctccttc      180

gcagacggtt tccctaacct cttcatcaat aacgcacacg atatccgcgg ccagcacgtc      240

gcgttccttg caagcttcag ctccccagcc gttatctttg aacaaattag cgtgatttat      300

ttgcttcccc gcctcttcgt tgcctcattt actcttgtac ttccgttttt cccaacaggc      360

tccttcgaac gcatggaaga agagggagat gtcgcgaccg ctttcaccat ggctcgaatc      420

gtgagcaaca tcccgatctc ccgcggcgga cctactagcg ttgtgattta tgatatccac      480

gctctccaag aacgctttta ttttgccgac caggtcctgc ctttgttcga gactggcatc      540

cctcttttga cgaaacgtct gcaacaattg cccgaaaccg aaaaggtcat cgtggcattc      600

ccggatgatg gtgcctggaa gcgctttcac aaactcctgg atcattaccc caccgttgtc      660

tgtaccaaag tccgcgaggg tgacaagcgt attgtacgac ttaaagaggg caacccagct      720

ggctgccacg ttgtgatcgt ggatgacttg gtgcagtccg gtggaaccct tatcgaatgt      780

cagaaagtcc tcgcggcgca cggcgctgtt aaggtttccg catacgttac tcacggagtt      840

ttcccaaagt cttcctggga acgcttcact cataagaaaa atggcctgga agaggcattc      900

gcttattttt ggattacaga ctcgtgcccg cagactgtta aggctattgg taataaggct      960

ccattcgagg tcctcagcct ggctggctca attgctgatg ctctccaaat c              1011


<210>  135
<211>  1251
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  135
atggcccttc ttcccttctt cgacctcacc aacttcgagt ccgatgcttc cgaggaactg       60

ggttggctta aatacgtcgg ccgagtacag acacgtgtgt ttccacagca ttttaaggac      120

aatttggaaa aagtgcgcaa aatctccgag actattgatg tcatcgtaga taccaccgct      180

gagttgggcc cggaagcatg tgtgaatctg ctcaatgctg gtgcattggc aatcttggtg      240

aacgaggaga tgcttaatga gttggcagac atctcaccta accgccttgt gttgaagacc      300

gataccaccg atatcggaaa aatcgaaaag ctgtcccagg ttgccggttc gatccagtgg      360

attggaagcg cagagaacta cccaccagat tttttcgaac gtgcatcgaa gatcatccat      420

aaggccgtca tgcctgaagg cggcggacgt actctgtacc tggaattccc agagcaacca      480

tcaatggagg tcctgaaaag cttttcggtg cacagcgttg ttcctgtgct ttcgtcctct      540

ttcctcaccg taaagcccgc agaagaacct aagaaactct ccctggcaga tctcatcctc      600

atctccgcga ataccgaccg cgaggatggc cttttctcaa cactggtggt caacgagctg      660

ggaatcgcac tcggcctcgt gtattcctcc aaagagtcgg tcgcagaatc cttgaagacg      720

ggtactggag tgtaccaatc ccgtaagcga ggactctggt acaagggcgc cagctccggc      780

gcagtccaac acctcattca cattgacgtt gattgcgacg aggattgcct gcgcttcgtg      840

gtttatcaaa ccggaaaagg cttctgccac ctggacactc tgcattgctt tggtcaggcc      900

agcggcttgt gtcagctcga aaaaacgctc atcgatcgta aaaacaatgc gcctgagggc      960

agctacacgg cccgcctgtt ctccgatccc aagcttcttc gagcgaagat tatggaggaa     1020

gccgaggagc tgtgtgatgc caccacgaag gaaaacgtga tctgggaaat ggcggatttg     1080

atgtattttg ccattactcg ttgtgtcggc tccggtgtct cactcaacga cattagccgt     1140

catctggacc tgaagcaccg caaagtgaca cgccgtaaag gtgatgcgaa agtagcatgg     1200

caagagaaat tgaaggataa gggtggcgtg gcaaatacat cctatactgc g              1251


<210>  136
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  136
atgcactccc accactcgca ctcgggagat tactccgctc atggcaccga tcccctcgat       60

tccgttgtcg atcaagtcgt gaacttgaat ttccacactt actgcttgac agagcatatc      120

ccccgtattg aagccaaatt catttacccg gaggaacagt cgttgggtaa gaacccagag      180

gaagttatta ctaagctcga gacgtccttc aagaatttca tgtcccacgc tcaggagatc      240

aagacccgtt atgccgaccg cccagacgtg cgcaccaaat tcattatcgg tatggagatc      300

gaaagctgtg acatggctca catcgagtat gccaaacgct tgatgaagga aaacaatgac      360

atcctcaagt tctgcgttgg atccgtacac cacgtgaatg gcatccccat tgattttgat      420

cagcagcagt ggtacaactc cctccattcc tttaacgata acctgaagca cttcttgttg      480

tcttactttc aatctcagta tgagatgctc attaacatta agcctctggt ggtcggtcat      540

ttcgacctgt acaaactctt cctgccgaat gacatgttgg ttaatcaaaa atctggtaac      600

tgtaacgaag aaaccggtgt acccgtcgca tcccttgatg ttatttcaga atggcctgag      660

atctacgatg cagtggttcg taaccttcag tttatcgatt catacggcgg cgctatcgaa      720

attaacacct ccgcgttgcg caagcgtctg gaggaaccat acccctctaa aaccctgtgc      780

aacttggtca aaaagcattg cggttcccgc tttgtgctga gcgacgatgc acacggagtg      840

gcacaggtcg gtgtgtgcta tgacaaagtt aagaagtaca ttgtggacgt gctccaactc      900

gaatacatct gttatctgga agaatcacaa tctccagaaa atctgctcac tgtcaagcga      960

ttgccaatct cccaatttgt taatgaccca ttttgggcga acatc                     1005


<210>  137
<211>  1542
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  137
atgtctacca acaccactcc ttcctcctgg accaatcctt tgcgtgatcc acaggataag       60

cgtctcccgc gcattgctgg tccttccggt atggttatct tcggtgtaac tggtgatctg      120

gctcgtaaga agctgttgcc agcgatctat gacctggcca atcgcggcct gctcccccca      180

ggcttcagcc tggtcggtta cggccgccgc gagtggagca aggaggactt cgagaaatat      240

gtgcgcgatg cagcgtcagc cggtgcacgt accgaatttc gtgagaacgt ttgggaacgc      300

ctcgcggaag gtatggaatt cgttcgtggt aatttcgacg atgacgccgc ttttgataat      360

ctcgccgcga ccctcaaacg cattgacaaa acgcgcggta ctgcaggtaa ttgggcatac      420

tatctcagca ttccccccga tagctttgcg gcagtatgcc accagctgga acgctccggt      480

atggccgaat ccaccgagga ggcttggcgt cgcgtcatca tcgagaagcc attcggtcac      540

aacctggaat ccgcgcacga acttaaccag ttggtgaatg ccgtgtttcc agaatctagc      600

gtgttccgca tcgatcacta ccttggaaag gaaaccgtgc aaaacatcct tgctctgcgc      660

ttcgctaacc agttgtttga gccgctgtgg aactcaaatt acgttgacca cgtgcagatc      720

actatgacgg aggatatcgg cttgggcggt cgcgccggct actacgacgg tattggagca      780

gcgcgtgacg tgattcaaaa ccatctcatc cagctgctcg cactggttgc aatggaagaa      840

ccgatttcat tcgtcccagc tcaactgcag gctgaaaaga tcaaagtcct gtctgcgaca      900

aagccttgct accctctcga caagacctcg gcacgcggac aatatgcagc cggctggcag      960

ggctccgaac tggttaaggg actccgcgaa gaggatggct ttaacccaga gtccacaacc     1020

gagactttcg ctgcatgcac acttgagatc acatcacgcc gttgggctgg cgtaccgttc     1080

tacctgcgta cgggcaagcg cctgggccgc cgcgtaaccg agatcgcagt tgtgttcaag     1140

gatgctcccc accagccatt cgatggtgat atgaccgttt ctctgggtca aaacgctatt     1200

gtgattcgcg tacagcctga tgaaggcgtt ttgatccgtt tcggttcaaa agtgcctggc     1260

tccgcaatgg aggtacgcga tgtcaatatg gattttagct actctgagtc atttaccgag     1320

gaatcgccag aagcatacga acgcctgatc ctggatgcac tccttgatga gtcttcgctc     1380

ttccctacca acgaagaggt agaactttcc tggaaaattc tggacccaat tctggaagca     1440

tgggatgcag atggcgaacc tgaggactat ccggcaggca cgtggggccc taagtccgcg     1500

gacgaaatgt tgagccgcaa cggccacaca tggcgtcgtc ca                        1542


<210>  138
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  138
atgtctgagc tggatgctaa gctgaacaag ctcggagtgg accgaattgc tatctcgccc       60

tacaagcagt ggactcgagg atacatggag cccggcaaca tcggaaatgg atacgtcacg      120

ggacttaagg tcgatgcagg tgtgcgagac aagtccgacg acgacgtcct ggacggaatt      180

gtttcctacg atagagcaga gactaagaac gcttacattg gacaaatcaa catgaccaca      240

gctagctctt tcactggcgt tcaaggccga gtgatcggat acgacattct tcgatctccc      300

gaggtcgata aggccaagcc tctgtttacc gagacccagt gggatggttc cgagcttcct      360

atctacgacg ctaagcctct tcaggatgct ctggttgagt actttggtac tgagcaggat      420

cgtcgtcact acccagctcc cggttccttc atcgtttgtg ctaacaaagg cgtcaccgcc      480

gaacgaccaa agaacgacgc cgatatgaag cccggtcaag gatacggcgt ttggtccgcc      540

atcgctatta gcttcgctaa ggaccctacc aaggactcct ctatgttcgt tgaggacgct      600

ggtgtgtggg agacccctaa cgaggacgag ctgcttgagt acctcgaggg tagacgaaag      660

gccatggcta agtccattgc agaatgtggt caggatgccc acgcctcgtt cgaatcctcc      720

tggattggtt tcgcatacac aatgatggag ccaggccaga ttggtaacgc tattaccgtt      780

gccccctacg tgtctctgcc cattgattcc atccctggtg gctctatcct tactcctgac      840

aaggatatgg agatcatgga gaacctcacc atgccagagt ggctcgaaaa aatgggctac      900

aagtctctct ctgctaacaa cgcccttaag tac                                   933


<210>  139
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  139
atgtcgctct ccccgctcga ccaaaaccgc atcgaaagct tctggcagta ttgtctccaa       60

caccagtatt ttaatttggc atatccggaa agcgctgatt ttgattacgc acccttgcat      120

cgctttctgc gcttttccat caacaattgc ggcgattgga acgaaagctc gaactacctg      180

ttgaactctt tcgactttga gcgcgaagtg atgcacttct tcgcagaact gttccacatt      240

ccgttcgacg agtcgtgggg ttacgtgacg aacggcggta cagaaggaaa catgttcggt      300

tgctatctgg ctcgcgaact cttccctgat gcgaccctct actactccaa agattcccac      360

tattccgttg ccaagatcat caaactcttg cgcattaagt cccgcgcagt ggattccctc      420

ccttccggag aaatcgacta cgacgatctc gtggcgaaga tccaacagga ccaggaacga      480

caccctatcg tctttgtcaa tgtaggcact acgatgaaag gtgcggtgga tgacatcggt      540

gtgatccagc ataagcttgc agaagcaggt atcccacgtc aagactacta cctgcacgca      600

gacgcagccc tctcaggtat gatcctccct tttgtggacg caccgcagcc gtattcattt      660

gctgatggca ttgatagcat ctccgtctca ggacataaga tgattggctc tccgatgcct      720

tgcggcattg tactggcgaa gcgctccaac gtgtctcgaa tctccgttga gatcgactac      780

atttccgcaa aggatcagac tatttctggc tctcgaaatg gtcacacgcc catgatgctc      840

tgggcagcta tcaaatcccg tcccctggct gaatggcgcc gtaaagtccg ccattgcctg      900

gatatggccc aatatgccat cgaccgcttg caagctgcag gcatccaagc atggcgctgt      960

aagaacagca ttacggtagt cttcccttcc ccctccgaac cagtgtgcga taaacacggt     1020

ctcgctcgct ccggaggcac cgctcacctc atcaccactc cacaccacca cgattcccag     1080

cgcctcgatc gcctgctgga cgacatcgta caggaccttg gagcgatgac ggcaccagcg     1140

ggtgctacta tgtctgccgc g                                               1161


<210>  140
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  140
atgctgaaga ttgccgtgcc gaataagggc tctcttagcg aacgtgcgat ggagattctc       60

gccgaagctg gctatgccgg ccgcggcgac tcgaaatcgc tgaacgtgtt tgacgaagca      120

aataacgttg aatttttctt ccttcgaccg aaagacattg caatctatgt ggctggcggc      180

cagcttgatc tgggaatcac gggacgcgac ttggcacgcg actcacaggc agatgttcac      240

gaagtcttga gcttgggttt cggctcgtcg actttccgct acgcggcacc agctgatgag      300

gaatggtcca ttgaaaaact cgatggtaaa cgcattgcta ccagctaccc taatctcgtt      360

cgcgatgatc tcgcagcacg tggactcagc gccgaggtgt tgcgcttgga cggagccgtg      420

gaagtctcca tcaagctcgg cgtggctgac gcgatcgctg atgtggtgtc aaccggccgc      480

acactccgtc aacagggcct ggctcctttc ggtgaggtgc tttgtacctc cgaagcggtg      540

attgtcggtc gtaaggatga gaaggtgaca cccgagcagc agatcttgtt gcgacgaatt      600

cagggtatct tgcatgcgca gaacttcctt atgctggatt acaaggttga tcgagacaat      660

ctcgatgcag ctactgcagt tacccctggc ttctccggcc ctgccgtatc accccttgcg      720

cgtgataatt gggtcgcagt gcgcgcaatg gttcctcgtc gctccgcgaa cgctatcatg      780

gataaactgg ctggactggg tgccgaagct atccttgcta gcgaaatccg catcgcgcga      840

atc                                                                    843


<210>  141
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized and/or mutated sequence

<400>  141
atgctaaaga tagcagtacc caacaaaggt agcctaagcg agagagctat ggaaatcttg       60

gctgaggctg gctatgctgg gagaggagac tccaaatctc taaatgtgtt tgacgaggct      120

aataatgttg agtttttttt tcttagacca aaggatatcg ccatatatgt cgcgggagga      180

cagctagacc taggcatcac cggcagggat ctagccaggg acagccaagc agatgtccac      240

gaggtcctgt ctttaggatt tggatcttct accttcaggt atgcagcccc tgccgatgaa      300

gagtggtcta tcgagaagct agatggcaaa cgtatcgcca caagttatcc caatttggtc      360

agggatgatc tagccgcgag aggtttatca gccgaggtcc tgagacttga tggggccgtc      420

gaggttagta tcaaactagg tgttgcggat gcgattgcag acgtggtatc caccggaagg      480

acgctacgtc aacaagggct tgccccattc ggtgaggtgc tgtgcacatc cgaggctgtt      540

atcgtgggaa gaaaagacga aaaggttaca cctgagcagc agatattact aagaaggata      600

cagggaattc tgcacgctca aaactttcta atgctggatt ataaggttga tagggataac      660

ctagacgccg ccacagccgt tactcctggt ttctccggtc ccgctgtcag tcctctagct      720

agggacaact gggtcgccgt cagggctatg gttccaagac gtagcgctaa cgcaataatg      780

gacaaattgg cgggccttgg ggccgaagca atactggcga gcgaaatcag gattgcacgt      840

att                                                                    843


<210>  142
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Solubility tag

<400>  142

Met Gln Tyr Lys Leu Ala Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr 
1               5                   10                  15      


Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln 
            20                  25                  30          


Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala 
        35                  40                  45              


Thr Lys Thr Phe Thr Val Thr 
    50                  55  


<210>  143
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated

<400>  143

Met Ser Asn Glu Tyr Gly Asp Lys Asn Leu Lys Ile Phe Ser Leu Asn 
1               5                   10                  15      


Ser Asn Pro Glu Leu Ala Lys Glu Ile Ala Asp Asn Val Gly Val Gln 
            20                  25                  30          


Leu Gly Lys Cys Ser Val Thr Arg Phe Ser Asp Gly Glu Val Gln Ile 
        35                  40                  45              


Asn Ile Glu Glu Ser Ile Arg Gly Cys Asp Cys Tyr Ile Ile Gln Ser 
    50                  55                  60                  


Thr Ser Ala Pro Val Asn Glu His Ile Met Glu Leu Leu Ile Met Val 
65                  70                  75                  80  


Asp Ala Leu Lys Arg Ala Ser Ala Lys Thr Ile Asn Ile Val Ile Pro 
                85                  90                  95      


Tyr Tyr Gly Tyr Ala Arg Gln Asp Arg Lys Ala Arg Ser Arg Glu Pro 
            100                 105                 110         


Ile Thr Ala Lys Leu Phe Ala Asn Leu Leu Glu Thr Ala Gly Ala Thr 
        115                 120                 125             


Arg Val Ile Ala Leu Asp Ile His Ala Pro Gln Ile Gln Gly Phe Phe 
    130                 135                 140                 


Asp Ile Pro Ile Asp His Leu Met Gly Val Pro Ile Leu Gly His Tyr 
145                 150                 155                 160 


Phe Glu Gly Lys Asp Leu Lys Asp Ile Val Ile Val Ser Pro Asp His 
                165                 170                 175     


Gly Gly Val Thr Arg Ala Arg Lys Leu Ala Asp Arg Leu Lys Ala Pro 
            180                 185                 190         


Ile Ala Ile Ile Asp Lys Arg Arg Pro Arg Pro Asn Glu Val Glu Val 
        195                 200                 205             


Met Asn Ile Val Gly Asn Val Glu Gly Lys Thr Ala Ile Leu Ile Asp 
    210                 215                 220                 


Asp Ile Ile Asp Thr Ala Gly Thr Ile Thr Leu Ala Ala Asn Ala Leu 
225                 230                 235                 240 


Val Glu Asn Gly Ala Ala Glu Val Tyr Ala Cys Cys Thr His Pro Val 
                245                 250                 255     


Leu Ser Gly Pro Ala Val Glu Arg Ile Asn Asn Ser Lys Ile Lys Glu 
            260                 265                 270         


Leu Val Val Thr Asn Ser Ile Lys Leu Pro Glu Glu Lys Lys Ile Glu 
        275                 280                 285             


Arg Phe Lys Gln Leu Ser Val Gly Pro Leu Leu Ala Glu Ala Ile Ile 
    290                 295                 300                 


Arg Val His Glu Lys Gln Ser Val Ser Tyr Leu Phe Ser 
305                 310                 315         


