                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Sunahara, Roger K.
       Clark, Mary J.
       Kobilka, Brian K.
       Zhang, Cheng
       Liu, Xiangyu
       Gmeiner, Peter
       Stossel, Anne
       Hubner, Harald
       Dengler, Daniela
       Stanek, Markus
       Shoichet, Brian S.
       Korczynska, Magdalena
       Mahoney, Jacob P.
       Kaindl, Jonas
 
<120>  BETA-ADRENERGIC RECEPTOR ALLOSTERIC MODULATORS

<130>  048537-607001WO

<150>  62/660,832
<151>  2018-04-20

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile Asp Val Leu Cys Val 
1               5                   10                  15      


Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala Val Asp Arg Tyr Phe 
            20                  25                  30          


Ala Ile Thr Ser 
        35      


<210>  2
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln Glu Ala Lys 
            20                  25                  30          


Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu 
        35                  40          


<210>  3
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Gly Ser Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val 
1               5                   10                  15      


Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu 
            20                  25                  30          


Ala Ile Thr Ser 
        35      


<210>  4
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Asn Arg Ala Tyr Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Leu Cys Ile Met Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln 
            20                  25                  30          


Lys Gln Val Lys Lys Ile Asp Ser 
        35                  40  


<210>  5
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Gly Arg Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys 
1               5                   10                  15      


Thr Ala Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile 
            20                  25                  30          


Gly Val Ser Tyr 
        35      


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser Phe Tyr Leu Pro 
1               5                   10                  15      


Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr Val Val Ala Lys 
            20                  25                  30          


Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu 
        35                  40          


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Gly Lys Val Trp Cys Glu Ile Tyr Leu Ala Leu Asp Val Leu Phe Cys 
1               5                   10                  15      


Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Trp 
            20                  25                  30          


Ser Ile Thr Gln 
        35      


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Gln Lys Trp Tyr Val Ile Ser Ser Ser Ile Gly Ser Phe Phe Ala Pro 
1               5                   10                  15      


Cys Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys 
            20                  25                  30          


Arg Arg Thr Arg Val Pro Pro Ser Arg 
        35                  40      


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Gly Gln Val Thr Cys Asp Leu Phe Ile Ala Leu Asp Val Leu Cys Cys 
1               5                   10                  15      


Thr Ser Ser Ile Leu His Leu Cys Ala Ile Ala Leu Asp Arg Tyr Trp 
            20                  25                  30          


Ala Ile Thr Asp 
        35      


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro 
1               5                   10                  15      


Leu Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg 
            20                  25                  30          


Phe Arg Ile Arg Lys Thr Val Lys Lys Val 
        35                  40          


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Gly Pro Val Val Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser 
1               5                   10                  15      


Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe 
            20                  25                  30          


Cys Val Thr Lys 
        35      


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asn Ala Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro 
1               5                   10                  15      


Val Ile Ile Met Thr Val Leu Tyr Trp His Ile Ser Arg Ala Ser Lys 
            20                  25                  30          


Ser Arg Ile Lys Lys Asp Lys Lys Glu 
        35                  40      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gly Asn Leu Ala Cys Asp Leu Trp Leu Ala Ile Asp Tyr Val Ala Ser 
1               5                   10                  15      


Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg Tyr Phe 
            20                  25                  30          


Ser Ile Thr Arg 
        35      


<210>  14
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Met Pro 
1               5                   10                  15      


Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys Glu Thr Glu 
            20                  25                  30          


Lys Arg Thr Lys Glu Leu Ala Gly Leu 
        35                  40      


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Ser Arg Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys 
1               5                   10                  15      


Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr 
            20                  25                  30          


Ala Val Ala Met 
        35      


<210>  16
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val Leu Arg 
            20                  25                  30          


Arg Arg Arg Lys Arg Val Asn Thr Lys 
        35                  40      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Gly Asp Ala Gly Cys Arg Gly Tyr Tyr Phe Leu Arg Asp Ala Cys Thr 
1               5                   10                  15      


Tyr Ala Thr Ala Leu Asn Val Ala Ser Leu Ser Val Glu Arg Tyr Leu 
            20                  25                  30          


Ala Ile Cys His 
        35      


<210>  18
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Thr Ala Thr Val Lys Val Val Ile Gln Val Asn Thr Phe Met Ser Phe 
1               5                   10                  15      


Ile Phe Pro Met Val Val Ile Ser Val Leu Asn Thr Ile Ile Ala Asn 
            20                  25                  30          


Lys Leu Thr Val Met Val Arg Gln Ala Ala Glu Gln Gly 
        35                  40                  45  


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Gly Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp Tyr Tyr Asn Met 
1               5                   10                  15      


Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile 
            20                  25                  30          


Ala Val Cys His 
        35      


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Ser Trp Tyr Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala 
1               5                   10                  15      


Phe Val Val Pro Ile Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Leu 
            20                  25                  30          


Leu Arg Leu Arg Ser Val 
        35              


<210>  21
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Asp Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met 
1               5                   10                  15      


Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile 
            20                  25                  30          


Ala Val Cys His 
        35      


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile Phe Ala 
1               5                   10                  15      


Phe Val Ile Pro Val Leu Ile Ile Ile Val Cys Tyr Thr Leu Met Ile 
            20                  25                  30          


Leu Arg Leu Lys Ser Val 
        35              


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Gly Thr Ile Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met 
1               5                   10                  15      


Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg Tyr Ile 
            20                  25                  30          


Ala Val Cys His 
        35      


<210>  24
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala 
1               5                   10                  15      


Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile 
            20                  25                  30          


Leu Arg Leu Lys Ser Val 
        35              


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Gly Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp 
            20                  25                  30          


Val Ile Val Asn 
        35      


<210>  26
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val 
1               5                   10                  15      


Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser Ala Tyr Val Leu Met Ile 
            20                  25                  30          


Arg Met Leu Arg Ser Ser 
        35              


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala Val Asp Arg Tyr Phe 
1               5                   10                  15      


Ala Ile Thr Ser 
            20  


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Leu Val Ile Met Val Phe Val 
            20              


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu 
1               5                   10                  15      


Ala Ile Thr Ser 
            20  


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Asn Arg Ala Tyr Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Leu Cys Ile Met Ala Phe 
            20          


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Thr Ala Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile 
1               5                   10                  15      


Gly Val Ser Tyr 
            20  


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser Phe Tyr Leu Pro 
1               5                   10                  15      


Leu Ala Ile Ile Leu Val 
            20          


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Trp 
1               5                   10                  15      


Ser Ile Thr Gln 
            20  


<210>  34
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Gln Lys Trp Tyr Val Ile Ser Ser Ser Ile Gly Ser Phe Phe Ala Pro 
1               5                   10                  15      


Cys Leu Ile Met Ile Leu 
            20          


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Thr Ser Ser Ile Leu His Leu Cys Ala Ile Ala Leu Asp Arg Tyr Trp 
1               5                   10                  15      


Ala Ile Thr Asp 
            20  


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Asp His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro 
1               5                   10                  15      


Leu Leu Leu Met Leu Val 
            20          


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe 
1               5                   10                  15      


Cys Val Thr Lys 
            20  


<210>  38
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Asn Ala Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro 
1               5                   10                  15      


Val Ile Ile Met Thr Val 
            20          


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg Tyr Phe 
1               5                   10                  15      


Ser Ile Thr Arg 
            20  


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Met Pro 
1               5                   10                  15      


Val Thr Ile Met Thr Ile 
            20          


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr 
1               5                   10                  15      


Ala Val Ala Met 
            20  


<210>  42
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val Pro 
1               5                   10                  15      


Phe Ile Val Thr Leu Leu 
            20          


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Tyr Ala Thr Ala Leu Asn Val Ala Ser Leu Ser Val Glu Arg Tyr Leu 
1               5                   10                  15      


Ala Ile Cys His 
            20  


<210>  44
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Thr Ala Thr Val Lys Val Val Ile Gln Val Asn Thr Phe Met Ser Phe 
1               5                   10                  15      


Ile Phe Pro Met Val Val Ile Ser Val 
            20                  25  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile 
1               5                   10                  15      


Ala Val Cys His 
            20  


<210>  46
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Ser Trp Tyr Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala 
1               5                   10                  15      


Phe Val Val Pro Ile Leu Ile Ile Thr Val 
            20                  25      


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile 
1               5                   10                  15      


Ala Val Cys His 
            20  


<210>  48
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile Phe Ala 
1               5                   10                  15      


Phe Val Ile Pro Val Leu Ile Ile Ile Val 
            20                  25      


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg Tyr Ile 
1               5                   10                  15      


Ala Val Cys His 
            20  


<210>  50
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala 
1               5                   10                  15      


Phe Ile Met Pro Val Leu Ile Ile Thr Val 
            20                  25      


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Tyr Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp 
1               5                   10                  15      


Val Ile Val Asn 
            20  


<210>  52
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Leu Val Gly Asp Met Phe Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val 
1               5                   10                  15      


Phe Leu Phe Pro Ala Phe Leu Thr Ala Ser 
            20                  25      


<210>  53
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


