                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Chen, Jin
       Gilbert, Luke
       Nunez, James
       Weissman, Jonathan
 
<120>  Compositions and Methods for Gene Editing

<130>  048536-620001WO

<140>  PCT/US2019/028377
<141>  2019-04-19

<150>  US 62/660,023
<151>  2018-04-19

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  2294
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Glu  Ala Ser Gly 
    1460                 1465                 1470             


Ser Gly  Arg Ala Ser Pro Gly  Ile Pro Gly Ser Thr  Arg Asn His 
    1475                 1480                 1485             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1490                 1495                 1500             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1505                 1510                 1515             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1520                 1525                 1530             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1535                 1540                 1545             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1550                 1555                 1560             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1565                 1570                 1575             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1580                 1585                 1590             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1595                 1600                 1605             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1610                 1615                 1620             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1625                 1630                 1635             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1640                 1645                 1650             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1655                 1660                 1665             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1670                 1675                 1680             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1685                 1690                 1695             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1700                 1705                 1710             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1715                 1720                 1725             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1730                 1735                 1740             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1745                 1750                 1755             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1760                 1765                 1770             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1775                 1780                 1785             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1790                 1795                 1800             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1805                 1810                 1815             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1820                 1825                 1830             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1835                 1840                 1845             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1850                 1855                 1860             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1865                 1870                 1875             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1880                 1885                 1890             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1895                 1900                 1905             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1910                 1915                 1920             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    1925                 1930                 1935             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    1940                 1945                 1950             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    1955                 1960                 1965             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    1970                 1975                 1980             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    1985                 1990                 1995             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2000                 2005                 2010             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2015                 2020                 2025             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2030                 2035                 2040             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2045                 2050                 2055             


Asn Pro  Gly Pro Ser Glu Leu  Ile Lys Glu Asn Met  His Met Lys 
    2060                 2065                 2070             


Leu Tyr  Met Glu Gly Thr Val  Asp Asn His His Phe  Lys Cys Thr 
    2075                 2080                 2085             


Ser Glu  Gly Glu Gly Lys Pro  Tyr Glu Gly Thr Gln  Thr Met Arg 
    2090                 2095                 2100             


Ile Lys  Val Val Glu Gly Gly  Pro Leu Pro Phe Ala  Phe Asp Ile 
    2105                 2110                 2115             


Leu Ala  Thr Ser Phe Leu Tyr  Gly Ser Lys Thr Phe  Ile Asn His 
    2120                 2125                 2130             


Thr Gln  Gly Ile Pro Asp Phe  Phe Lys Gln Ser Phe  Pro Glu Gly 
    2135                 2140                 2145             


Phe Thr  Trp Glu Arg Val Thr  Thr Tyr Glu Asp Gly  Gly Val Leu 
    2150                 2155                 2160             


Thr Ala  Thr Gln Asp Thr Ser  Leu Gln Asp Gly Cys  Leu Ile Tyr 
    2165                 2170                 2175             


Asn Val  Lys Ile Arg Gly Val  Asn Phe Thr Ser Asn  Gly Pro Val 
    2180                 2185                 2190             


Met Gln  Lys Lys Thr Leu Gly  Trp Glu Ala Phe Thr  Glu Thr Leu 
    2195                 2200                 2205             


Tyr Pro  Ala Asp Gly Gly Leu  Glu Gly Arg Asn Asp  Met Ala Leu 
    2210                 2215                 2220             


Lys Leu  Val Gly Gly Ser His  Leu Ile Ala Asn Ile  Lys Thr Thr 
    2225                 2230                 2235             


Tyr Arg  Ser Lys Lys Pro Ala  Lys Asn Leu Lys Met  Pro Gly Val 
    2240                 2245                 2250             


Tyr Tyr  Val Asp Tyr Arg Leu  Glu Arg Ile Lys Glu  Ala Asn Asn 
    2255                 2260                 2265             


Glu Thr  Tyr Val Glu Gln His  Glu Val Ala Val Ala  Arg Tyr Cys 
    2270                 2275                 2280             


Asp Leu  Pro Ser Lys Leu Gly  His Lys Leu Asn 
    2285                 2290                 


<210>  2
<211>  2296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Pro Gly Ser 
    1460                 1465                 1470             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1475                 1480                 1485             


Asn His  Asp Gln Glu Phe Asp  Pro Pro Lys Val Tyr  Pro Pro Val 
    1490                 1495                 1500             


Pro Ala  Glu Lys Arg Lys Pro  Ile Arg Val Leu Ser  Leu Phe Asp 
    1505                 1510                 1515             


Gly Ile  Ala Thr Gly Leu Leu  Val Leu Lys Asp Leu  Gly Ile Gln 
    1520                 1525                 1530             


Val Asp  Arg Tyr Ile Ala Ser  Glu Val Cys Glu Asp  Ser Ile Thr 
    1535                 1540                 1545             


Val Gly  Met Val Arg His Gln  Gly Lys Ile Met Tyr  Val Gly Asp 
    1550                 1555                 1560             


Val Arg  Ser Val Thr Gln Lys  His Ile Gln Glu Trp  Gly Pro Phe 
    1565                 1570                 1575             


Asp Leu  Val Ile Gly Gly Ser  Pro Cys Asn Asp Leu  Ser Ile Val 
    1580                 1585                 1590             


Asn Pro  Ala Arg Lys Gly Leu  Tyr Glu Gly Thr Gly  Arg Leu Phe 
    1595                 1600                 1605             


Phe Glu  Phe Tyr Arg Leu Leu  His Asp Ala Arg Pro  Lys Glu Gly 
    1610                 1615                 1620             


Asp Asp  Arg Pro Phe Phe Trp  Leu Phe Glu Asn Val  Val Ala Met 
    1625                 1630                 1635             


Gly Val  Ser Asp Lys Arg Asp  Ile Ser Arg Phe Leu  Glu Ser Asn 
    1640                 1645                 1650             


Pro Val  Met Ile Asp Ala Lys  Glu Val Ser Ala Ala  His Arg Ala 
    1655                 1660                 1665             


Arg Tyr  Phe Trp Gly Asn Leu  Pro Gly Met Asn Arg  Pro Leu Ala 
    1670                 1675                 1680             


Ser Thr  Val Asn Asp Lys Leu  Glu Leu Gln Glu Cys  Leu Glu His 
    1685                 1690                 1695             


Gly Arg  Ile Ala Lys Phe Ser  Lys Val Arg Thr Ile  Thr Thr Arg 
    1700                 1705                 1710             


Ser Asn  Ser Ile Lys Gln Gly  Lys Asp Gln His Phe  Pro Val Phe 
    1715                 1720                 1725             


Met Asn  Glu Lys Glu Asp Ile  Leu Trp Cys Thr Glu  Met Glu Arg 
    1730                 1735                 1740             


Val Phe  Gly Phe Pro Val His  Tyr Thr Asp Val Ser  Asn Met Ser 
    1745                 1750                 1755             


Arg Leu  Ala Arg Gln Arg Leu  Leu Gly Arg Ser Trp  Ser Val Pro 
    1760                 1765                 1770             


Val Ile  Arg His Leu Phe Ala  Pro Leu Lys Glu Tyr  Phe Ala Cys 
    1775                 1780                 1785             


Val Ser  Ser Gly Asn Ser Asn  Ala Asn Ser Arg Gly  Pro Ser Phe 
    1790                 1795                 1800             


Ser Ser  Gly Leu Val Pro Leu  Ser Leu Arg Gly Ser  His Met Gly 
    1805                 1810                 1815             


Pro Met  Glu Ile Tyr Lys Thr  Val Ser Ala Trp Lys  Arg Gln Pro 
    1820                 1825                 1830             


Val Arg  Val Leu Ser Leu Phe  Arg Asn Ile Asp Lys  Val Leu Lys 
    1835                 1840                 1845             


Ser Leu  Gly Phe Leu Glu Ser  Gly Ser Gly Ser Gly  Gly Gly Thr 
    1850                 1855                 1860             


Leu Lys  Tyr Val Glu Asp Val  Thr Asn Val Val Arg  Arg Asp Val 
    1865                 1870                 1875             


Glu Lys  Trp Gly Pro Phe Asp  Leu Val Tyr Gly Ser  Thr Gln Pro 
    1880                 1885                 1890             


Leu Gly  Ser Ser Cys Asp Arg  Cys Pro Gly Trp Tyr  Met Phe Gln 
    1895                 1900                 1905             


Phe His  Arg Ile Leu Gln Tyr  Ala Leu Pro Arg Gln  Glu Ser Gln 
    1910                 1915                 1920             


Arg Pro  Phe Phe Trp Ile Phe  Met Asp Asn Leu Leu  Leu Thr Glu 
    1925                 1930                 1935             


Asp Asp  Gln Glu Thr Thr Thr  Arg Phe Leu Gln Thr  Glu Ala Val 
    1940                 1945                 1950             


Thr Leu  Gln Asp Val Arg Gly  Arg Asp Tyr Gln Asn  Ala Met Arg 
    1955                 1960                 1965             


Val Trp  Ser Asn Ile Pro Gly  Leu Lys Ser Lys His  Ala Pro Leu 
    1970                 1975                 1980             


Thr Pro  Lys Glu Glu Glu Tyr  Leu Gln Ala Gln Val  Arg Ser Arg 
    1985                 1990                 1995             


Ser Lys  Leu Asp Ala Pro Lys  Val Asp Leu Leu Val  Lys Asn Cys 
    2000                 2005                 2010             


Leu Leu  Pro Leu Arg Glu Tyr  Phe Lys Tyr Phe Ser  Gln Asn Ser 
    2015                 2020                 2025             


Leu Pro  Leu Ser Arg Ala Asp  Pro Lys Lys Lys Arg  Lys Val Gly 
    2030                 2035                 2040             


Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val 
    2045                 2050                 2055             


Glu Glu  Asn Pro Gly Pro Ser  Glu Leu Ile Lys Glu  Asn Met His 
    2060                 2065                 2070             


Met Lys  Leu Tyr Met Glu Gly  Thr Val Asp Asn His  His Phe Lys 
    2075                 2080                 2085             


Cys Thr  Ser Glu Gly Glu Gly  Lys Pro Tyr Glu Gly  Thr Gln Thr 
    2090                 2095                 2100             


Met Arg  Ile Lys Val Val Glu  Gly Gly Pro Leu Pro  Phe Ala Phe 
    2105                 2110                 2115             


Asp Ile  Leu Ala Thr Ser Phe  Leu Tyr Gly Ser Lys  Thr Phe Ile 
    2120                 2125                 2130             


Asn His  Thr Gln Gly Ile Pro  Asp Phe Phe Lys Gln  Ser Phe Pro 
    2135                 2140                 2145             


Glu Gly  Phe Thr Trp Glu Arg  Val Thr Thr Tyr Glu  Asp Gly Gly 
    2150                 2155                 2160             


Val Leu  Thr Ala Thr Gln Asp  Thr Ser Leu Gln Asp  Gly Cys Leu 
    2165                 2170                 2175             


Ile Tyr  Asn Val Lys Ile Arg  Gly Val Asn Phe Thr  Ser Asn Gly 
    2180                 2185                 2190             


Pro Val  Met Gln Lys Lys Thr  Leu Gly Trp Glu Ala  Phe Thr Glu 
    2195                 2200                 2205             


Thr Leu  Tyr Pro Ala Asp Gly  Gly Leu Glu Gly Arg  Asn Asp Met 
    2210                 2215                 2220             


Ala Leu  Lys Leu Val Gly Gly  Ser His Leu Ile Ala  Asn Ile Lys 
    2225                 2230                 2235             


Thr Thr  Tyr Arg Ser Lys Lys  Pro Ala Lys Asn Leu  Lys Met Pro 
    2240                 2245                 2250             


Gly Val  Tyr Tyr Val Asp Tyr  Arg Leu Glu Arg Ile  Lys Glu Ala 
    2255                 2260                 2265             


Asn Asn  Glu Thr Tyr Val Glu  Gln His Glu Val Ala  Val Ala Arg 
    2270                 2275                 2280             


Tyr Cys  Asp Leu Pro Ser Lys  Leu Gly His Lys Leu  Asn 
    2285                 2290                 2295     


<210>  3
<211>  2316
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Glu  Ala Ser Gly 
    1460                 1465                 1470             


Ser Gly  Arg Ala Ser Pro Gly  Ile Pro Gly Ser Thr  Arg Asn His 
    1475                 1480                 1485             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1490                 1495                 1500             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1505                 1510                 1515             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1520                 1525                 1530             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1535                 1540                 1545             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1550                 1555                 1560             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1565                 1570                 1575             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1580                 1585                 1590             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1595                 1600                 1605             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1610                 1615                 1620             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1625                 1630                 1635             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1640                 1645                 1650             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1655                 1660                 1665             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1670                 1675                 1680             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1685                 1690                 1695             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1700                 1705                 1710             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1715                 1720                 1725             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1730                 1735                 1740             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1745                 1750                 1755             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1760                 1765                 1770             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1775                 1780                 1785             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1790                 1795                 1800             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1805                 1810                 1815             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1820                 1825                 1830             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1835                 1840                 1845             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1850                 1855                 1860             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1865                 1870                 1875             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1880                 1885                 1890             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1895                 1900                 1905             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1910                 1915                 1920             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    1925                 1930                 1935             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    1940                 1945                 1950             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    1955                 1960                 1965             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    1970                 1975                 1980             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    1985                 1990                 1995             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2000                 2005                 2010             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2015                 2020                 2025             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2030                 2035                 2040             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2045                 2050                 2055             


Asn Pro  Gly Pro Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    2060                 2065                 2070             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Ser  Glu Leu Ile 
    2075                 2080                 2085             


Lys Glu  Asn Met His Met Lys  Leu Tyr Met Glu Gly  Thr Val Asp 
    2090                 2095                 2100             


Asn His  His Phe Lys Cys Thr  Ser Glu Gly Glu Gly  Lys Pro Tyr 
    2105                 2110                 2115             


Glu Gly  Thr Gln Thr Met Arg  Ile Lys Val Val Glu  Gly Gly Pro 
    2120                 2125                 2130             


Leu Pro  Phe Ala Phe Asp Ile  Leu Ala Thr Ser Phe  Leu Tyr Gly 
    2135                 2140                 2145             


Ser Lys  Thr Phe Ile Asn His  Thr Gln Gly Ile Pro  Asp Phe Phe 
    2150                 2155                 2160             


Lys Gln  Ser Phe Pro Glu Gly  Phe Thr Trp Glu Arg  Val Thr Thr 
    2165                 2170                 2175             


Tyr Glu  Asp Gly Gly Val Leu  Thr Ala Thr Gln Asp  Thr Ser Leu 
    2180                 2185                 2190             


Gln Asp  Gly Cys Leu Ile Tyr  Asn Val Lys Ile Arg  Gly Val Asn 
    2195                 2200                 2205             


Phe Thr  Ser Asn Gly Pro Val  Met Gln Lys Lys Thr  Leu Gly Trp 
    2210                 2215                 2220             


Glu Ala  Phe Thr Glu Thr Leu  Tyr Pro Ala Asp Gly  Gly Leu Glu 
    2225                 2230                 2235             


Gly Arg  Asn Asp Met Ala Leu  Lys Leu Val Gly Gly  Ser His Leu 
    2240                 2245                 2250             


Ile Ala  Asn Ile Lys Thr Thr  Tyr Arg Ser Lys Lys  Pro Ala Lys 
    2255                 2260                 2265             


Asn Leu  Lys Met Pro Gly Val  Tyr Tyr Val Asp Tyr  Arg Leu Glu 
    2270                 2275                 2280             


Arg Ile  Lys Glu Ala Asn Asn  Glu Thr Tyr Val Glu  Gln His Glu 
    2285                 2290                 2295             


Val Ala  Val Ala Arg Tyr Cys  Asp Leu Pro Ser Lys  Leu Gly His 
    2300                 2305                 2310             


Lys Leu  Asn 
    2315     


<210>  4
<211>  2318
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Pro Gly Ser 
    1460                 1465                 1470             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1475                 1480                 1485             


Asn His  Asp Gln Glu Phe Asp  Pro Pro Lys Val Tyr  Pro Pro Val 
    1490                 1495                 1500             


Pro Ala  Glu Lys Arg Lys Pro  Ile Arg Val Leu Ser  Leu Phe Asp 
    1505                 1510                 1515             


Gly Ile  Ala Thr Gly Leu Leu  Val Leu Lys Asp Leu  Gly Ile Gln 
    1520                 1525                 1530             


Val Asp  Arg Tyr Ile Ala Ser  Glu Val Cys Glu Asp  Ser Ile Thr 
    1535                 1540                 1545             


Val Gly  Met Val Arg His Gln  Gly Lys Ile Met Tyr  Val Gly Asp 
    1550                 1555                 1560             


Val Arg  Ser Val Thr Gln Lys  His Ile Gln Glu Trp  Gly Pro Phe 
    1565                 1570                 1575             


Asp Leu  Val Ile Gly Gly Ser  Pro Cys Asn Asp Leu  Ser Ile Val 
    1580                 1585                 1590             


Asn Pro  Ala Arg Lys Gly Leu  Tyr Glu Gly Thr Gly  Arg Leu Phe 
    1595                 1600                 1605             


Phe Glu  Phe Tyr Arg Leu Leu  His Asp Ala Arg Pro  Lys Glu Gly 
    1610                 1615                 1620             


Asp Asp  Arg Pro Phe Phe Trp  Leu Phe Glu Asn Val  Val Ala Met 
    1625                 1630                 1635             


Gly Val  Ser Asp Lys Arg Asp  Ile Ser Arg Phe Leu  Glu Ser Asn 
    1640                 1645                 1650             


Pro Val  Met Ile Asp Ala Lys  Glu Val Ser Ala Ala  His Arg Ala 
    1655                 1660                 1665             


Arg Tyr  Phe Trp Gly Asn Leu  Pro Gly Met Asn Arg  Pro Leu Ala 
    1670                 1675                 1680             


Ser Thr  Val Asn Asp Lys Leu  Glu Leu Gln Glu Cys  Leu Glu His 
    1685                 1690                 1695             


Gly Arg  Ile Ala Lys Phe Ser  Lys Val Arg Thr Ile  Thr Thr Arg 
    1700                 1705                 1710             


Ser Asn  Ser Ile Lys Gln Gly  Lys Asp Gln His Phe  Pro Val Phe 
    1715                 1720                 1725             


Met Asn  Glu Lys Glu Asp Ile  Leu Trp Cys Thr Glu  Met Glu Arg 
    1730                 1735                 1740             


Val Phe  Gly Phe Pro Val His  Tyr Thr Asp Val Ser  Asn Met Ser 
    1745                 1750                 1755             


Arg Leu  Ala Arg Gln Arg Leu  Leu Gly Arg Ser Trp  Ser Val Pro 
    1760                 1765                 1770             


Val Ile  Arg His Leu Phe Ala  Pro Leu Lys Glu Tyr  Phe Ala Cys 
    1775                 1780                 1785             


Val Ser  Ser Gly Asn Ser Asn  Ala Asn Ser Arg Gly  Pro Ser Phe 
    1790                 1795                 1800             


Ser Ser  Gly Leu Val Pro Leu  Ser Leu Arg Gly Ser  His Met Gly 
    1805                 1810                 1815             


Pro Met  Glu Ile Tyr Lys Thr  Val Ser Ala Trp Lys  Arg Gln Pro 
    1820                 1825                 1830             


Val Arg  Val Leu Ser Leu Phe  Arg Asn Ile Asp Lys  Val Leu Lys 
    1835                 1840                 1845             


Ser Leu  Gly Phe Leu Glu Ser  Gly Ser Gly Ser Gly  Gly Gly Thr 
    1850                 1855                 1860             


Leu Lys  Tyr Val Glu Asp Val  Thr Asn Val Val Arg  Arg Asp Val 
    1865                 1870                 1875             


Glu Lys  Trp Gly Pro Phe Asp  Leu Val Tyr Gly Ser  Thr Gln Pro 
    1880                 1885                 1890             


Leu Gly  Ser Ser Cys Asp Arg  Cys Pro Gly Trp Tyr  Met Phe Gln 
    1895                 1900                 1905             


Phe His  Arg Ile Leu Gln Tyr  Ala Leu Pro Arg Gln  Glu Ser Gln 
    1910                 1915                 1920             


Arg Pro  Phe Phe Trp Ile Phe  Met Asp Asn Leu Leu  Leu Thr Glu 
    1925                 1930                 1935             


Asp Asp  Gln Glu Thr Thr Thr  Arg Phe Leu Gln Thr  Glu Ala Val 
    1940                 1945                 1950             


Thr Leu  Gln Asp Val Arg Gly  Arg Asp Tyr Gln Asn  Ala Met Arg 
    1955                 1960                 1965             


Val Trp  Ser Asn Ile Pro Gly  Leu Lys Ser Lys His  Ala Pro Leu 
    1970                 1975                 1980             


Thr Pro  Lys Glu Glu Glu Tyr  Leu Gln Ala Gln Val  Arg Ser Arg 
    1985                 1990                 1995             


Ser Lys  Leu Asp Ala Pro Lys  Val Asp Leu Leu Val  Lys Asn Cys 
    2000                 2005                 2010             


Leu Leu  Pro Leu Arg Glu Tyr  Phe Lys Tyr Phe Ser  Gln Asn Ser 
    2015                 2020                 2025             


Leu Pro  Leu Ser Arg Ala Asp  Pro Lys Lys Lys Arg  Lys Val Gly 
    2030                 2035                 2040             


Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val 
    2045                 2050                 2055             


Glu Glu  Asn Pro Gly Pro Gly  Ser Gly Ala Thr Asn  Phe Ser Leu 
    2060                 2065                 2070             


Leu Lys  Gln Ala Gly Asp Val  Glu Glu Asn Pro Gly  Pro Ser Glu 
    2075                 2080                 2085             


Leu Ile  Lys Glu Asn Met His  Met Lys Leu Tyr Met  Glu Gly Thr 
    2090                 2095                 2100             


Val Asp  Asn His His Phe Lys  Cys Thr Ser Glu Gly  Glu Gly Lys 
    2105                 2110                 2115             


Pro Tyr  Glu Gly Thr Gln Thr  Met Arg Ile Lys Val  Val Glu Gly 
    2120                 2125                 2130             


Gly Pro  Leu Pro Phe Ala Phe  Asp Ile Leu Ala Thr  Ser Phe Leu 
    2135                 2140                 2145             


Tyr Gly  Ser Lys Thr Phe Ile  Asn His Thr Gln Gly  Ile Pro Asp 
    2150                 2155                 2160             


Phe Phe  Lys Gln Ser Phe Pro  Glu Gly Phe Thr Trp  Glu Arg Val 
    2165                 2170                 2175             


Thr Thr  Tyr Glu Asp Gly Gly  Val Leu Thr Ala Thr  Gln Asp Thr 
    2180                 2185                 2190             


Ser Leu  Gln Asp Gly Cys Leu  Ile Tyr Asn Val Lys  Ile Arg Gly 
    2195                 2200                 2205             


Val Asn  Phe Thr Ser Asn Gly  Pro Val Met Gln Lys  Lys Thr Leu 
    2210                 2215                 2220             


Gly Trp  Glu Ala Phe Thr Glu  Thr Leu Tyr Pro Ala  Asp Gly Gly 
    2225                 2230                 2235             


Leu Glu  Gly Arg Asn Asp Met  Ala Leu Lys Leu Val  Gly Gly Ser 
    2240                 2245                 2250             


His Leu  Ile Ala Asn Ile Lys  Thr Thr Tyr Arg Ser  Lys Lys Pro 
    2255                 2260                 2265             


Ala Lys  Asn Leu Lys Met Pro  Gly Val Tyr Tyr Val  Asp Tyr Arg 
    2270                 2275                 2280             


Leu Glu  Arg Ile Lys Glu Ala  Asn Asn Glu Thr Tyr  Val Glu Gln 
    2285                 2290                 2295             


His Glu  Val Ala Val Ala Arg  Tyr Cys Asp Leu Pro  Ser Lys Leu 
    2300                 2305                 2310             


Gly His  Lys Leu Asn 
    2315             


<210>  5
<211>  2360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Pro Gly Gly 
    1460                 1465                 1470             


Gly Pro  Ser Ser Gly Ala Pro  Pro Pro Ser Gly Gly  Ser Pro Ala 
    1475                 1480                 1485             


Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr 
    1490                 1495                 1500             


Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 
    1505                 1510                 1515             


Ala Pro  Gly Ser Pro Ala Gly  Ser Pro Thr Ser Thr  Glu Glu Gly 
    1520                 1525                 1530             


Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Thr Ser Thr 
    1535                 1540                 1545             


Glu Pro  Ser Glu Asn His Asp  Gln Glu Phe Asp Pro  Pro Lys Val 
    1550                 1555                 1560             


Tyr Pro  Pro Val Pro Ala Glu  Lys Arg Lys Pro Ile  Arg Val Leu 
    1565                 1570                 1575             


Ser Leu  Phe Asp Gly Ile Ala  Thr Gly Leu Leu Val  Leu Lys Asp 
    1580                 1585                 1590             


Leu Gly  Ile Gln Val Asp Arg  Tyr Ile Ala Ser Glu  Val Cys Glu 
    1595                 1600                 1605             


Asp Ser  Ile Thr Val Gly Met  Val Arg His Gln Gly  Lys Ile Met 
    1610                 1615                 1620             


Tyr Val  Gly Asp Val Arg Ser  Val Thr Gln Lys His  Ile Gln Glu 
    1625                 1630                 1635             


Trp Gly  Pro Phe Asp Leu Val  Ile Gly Gly Ser Pro  Cys Asn Asp 
    1640                 1645                 1650             


Leu Ser  Ile Val Asn Pro Ala  Arg Lys Gly Leu Tyr  Glu Gly Thr 
    1655                 1660                 1665             


Gly Arg  Leu Phe Phe Glu Phe  Tyr Arg Leu Leu His  Asp Ala Arg 
    1670                 1675                 1680             


Pro Lys  Glu Gly Asp Asp Arg  Pro Phe Phe Trp Leu  Phe Glu Asn 
    1685                 1690                 1695             


Val Val  Ala Met Gly Val Ser  Asp Lys Arg Asp Ile  Ser Arg Phe 
    1700                 1705                 1710             


Leu Glu  Ser Asn Pro Val Met  Ile Asp Ala Lys Glu  Val Ser Ala 
    1715                 1720                 1725             


Ala His  Arg Ala Arg Tyr Phe  Trp Gly Asn Leu Pro  Gly Met Asn 
    1730                 1735                 1740             


Arg Pro  Leu Ala Ser Thr Val  Asn Asp Lys Leu Glu  Leu Gln Glu 
    1745                 1750                 1755             


Cys Leu  Glu His Gly Arg Ile  Ala Lys Phe Ser Lys  Val Arg Thr 
    1760                 1765                 1770             


Ile Thr  Thr Arg Ser Asn Ser  Ile Lys Gln Gly Lys  Asp Gln His 
    1775                 1780                 1785             


Phe Pro  Val Phe Met Asn Glu  Lys Glu Asp Ile Leu  Trp Cys Thr 
    1790                 1795                 1800             


Glu Met  Glu Arg Val Phe Gly  Phe Pro Val His Tyr  Thr Asp Val 
    1805                 1810                 1815             


Ser Asn  Met Ser Arg Leu Ala  Arg Gln Arg Leu Leu  Gly Arg Ser 
    1820                 1825                 1830             


Trp Ser  Val Pro Val Ile Arg  His Leu Phe Ala Pro  Leu Lys Glu 
    1835                 1840                 1845             


Tyr Phe  Ala Cys Val Ser Ser  Gly Asn Ser Asn Ala  Asn Ser Arg 
    1850                 1855                 1860             


Gly Pro  Ser Phe Ser Ser Gly  Leu Val Pro Leu Ser  Leu Arg Gly 
    1865                 1870                 1875             


Ser His  Met Gly Pro Met Glu  Ile Tyr Lys Thr Val  Ser Ala Trp 
    1880                 1885                 1890             


Lys Arg  Gln Pro Val Arg Val  Leu Ser Leu Phe Arg  Asn Ile Asp 
    1895                 1900                 1905             


Lys Val  Leu Lys Ser Leu Gly  Phe Leu Glu Ser Gly  Ser Gly Ser 
    1910                 1915                 1920             


Gly Gly  Gly Thr Leu Lys Tyr  Val Glu Asp Val Thr  Asn Val Val 
    1925                 1930                 1935             


Arg Arg  Asp Val Glu Lys Trp  Gly Pro Phe Asp Leu  Val Tyr Gly 
    1940                 1945                 1950             


Ser Thr  Gln Pro Leu Gly Ser  Ser Cys Asp Arg Cys  Pro Gly Trp 
    1955                 1960                 1965             


Tyr Met  Phe Gln Phe His Arg  Ile Leu Gln Tyr Ala  Leu Pro Arg 
    1970                 1975                 1980             


Gln Glu  Ser Gln Arg Pro Phe  Phe Trp Ile Phe Met  Asp Asn Leu 
    1985                 1990                 1995             


Leu Leu  Thr Glu Asp Asp Gln  Glu Thr Thr Thr Arg  Phe Leu Gln 
    2000                 2005                 2010             


Thr Glu  Ala Val Thr Leu Gln  Asp Val Arg Gly Arg  Asp Tyr Gln 
    2015                 2020                 2025             


Asn Ala  Met Arg Val Trp Ser  Asn Ile Pro Gly Leu  Lys Ser Lys 
    2030                 2035                 2040             


His Ala  Pro Leu Thr Pro Lys  Glu Glu Glu Tyr Leu  Gln Ala Gln 
    2045                 2050                 2055             


Val Arg  Ser Arg Ser Lys Leu  Asp Ala Pro Lys Val  Asp Leu Leu 
    2060                 2065                 2070             


Val Lys  Asn Cys Leu Leu Pro  Leu Arg Glu Tyr Phe  Lys Tyr Phe 
    2075                 2080                 2085             


Ser Gln  Asn Ser Leu Pro Leu  Ser Arg Ala Asp Pro  Lys Lys Lys 
    2090                 2095                 2100             


Arg Lys  Val Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2105                 2110                 2115             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Ser Glu  Leu Ile Lys 
    2120                 2125                 2130             


Glu Asn  Met His Met Lys Leu  Tyr Met Glu Gly Thr  Val Asp Asn 
    2135                 2140                 2145             


His His  Phe Lys Cys Thr Ser  Glu Gly Glu Gly Lys  Pro Tyr Glu 
    2150                 2155                 2160             


Gly Thr  Gln Thr Met Arg Ile  Lys Val Val Glu Gly  Gly Pro Leu 
    2165                 2170                 2175             


Pro Phe  Ala Phe Asp Ile Leu  Ala Thr Ser Phe Leu  Tyr Gly Ser 
    2180                 2185                 2190             


Lys Thr  Phe Ile Asn His Thr  Gln Gly Ile Pro Asp  Phe Phe Lys 
    2195                 2200                 2205             


Gln Ser  Phe Pro Glu Gly Phe  Thr Trp Glu Arg Val  Thr Thr Tyr 
    2210                 2215                 2220             


Glu Asp  Gly Gly Val Leu Thr  Ala Thr Gln Asp Thr  Ser Leu Gln 
    2225                 2230                 2235             


Asp Gly  Cys Leu Ile Tyr Asn  Val Lys Ile Arg Gly  Val Asn Phe 
    2240                 2245                 2250             


Thr Ser  Asn Gly Pro Val Met  Gln Lys Lys Thr Leu  Gly Trp Glu 
    2255                 2260                 2265             


Ala Phe  Thr Glu Thr Leu Tyr  Pro Ala Asp Gly Gly  Leu Glu Gly 
    2270                 2275                 2280             


Arg Asn  Asp Met Ala Leu Lys  Leu Val Gly Gly Ser  His Leu Ile 
    2285                 2290                 2295             


Ala Asn  Ile Lys Thr Thr Tyr  Arg Ser Lys Lys Pro  Ala Lys Asn 
    2300                 2305                 2310             


Leu Lys  Met Pro Gly Val Tyr  Tyr Val Asp Tyr Arg  Leu Glu Arg 
    2315                 2320                 2325             


Ile Lys  Glu Ala Asn Asn Glu  Thr Tyr Val Glu Gln  His Glu Val 
    2330                 2335                 2340             


Ala Val  Ala Arg Tyr Cys Asp  Leu Pro Ser Lys Leu  Gly His Lys 
    2345                 2350                 2355             


Leu Asn  
    2360 


<210>  6
<211>  2382
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Ser Gly Gly Gly Ser Met Asp 
65                  70                  75                  80  


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                85                  90                  95      


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            100                 105                 110         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        115                 120                 125             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    130                 135                 140                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
145                 150                 155                 160 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                165                 170                 175     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            180                 185                 190         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        195                 200                 205             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    210                 215                 220                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
225                 230                 235                 240 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                245                 250                 255     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            260                 265                 270         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        275                 280                 285             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    290                 295                 300                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
305                 310                 315                 320 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                325                 330                 335     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            340                 345                 350         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        355                 360                 365             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    370                 375                 380                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
385                 390                 395                 400 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                405                 410                 415     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            420                 425                 430         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        435                 440                 445             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    450                 455                 460                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
465                 470                 475                 480 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                485                 490                 495     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            500                 505                 510         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        515                 520                 525             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    530                 535                 540                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
545                 550                 555                 560 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                565                 570                 575     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            580                 585                 590         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        595                 600                 605             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    610                 615                 620                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
625                 630                 635                 640 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                645                 650                 655     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            660                 665                 670         


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
        675                 680                 685             


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
    690                 695                 700                 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
705                 710                 715                 720 


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
                725                 730                 735     


Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln 
            740                 745                 750         


Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 
        755                 760                 765             


Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu 
    770                 775                 780                 


Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu 
785                 790                 795                 800 


His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu 
                805                 810                 815     


Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His 
            820                 825                 830         


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        835                 840                 845             


Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu 
    850                 855                 860                 


Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 
865                 870                 875                 880 


Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn 
                885                 890                 895     


Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser 
            900                 905                 910         


Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp 
        915                 920                 925             


Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
    930                 935                 940                 


Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr 
945                 950                 955                 960 


Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
                965                 970                 975     


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala 
            980                 985                 990         


Gly Phe Ile Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
        995                 1000                 1005             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1010                 1015                 1020             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1025                 1030                 1035             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1040                 1045                 1050             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1055                 1060                 1065             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1070                 1075                 1080             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1085                 1090                 1095             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1100                 1105                 1110             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1115                 1120                 1125             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1130                 1135                 1140             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1145                 1150                 1155             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1160                 1165                 1170             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1175                 1180                 1185             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1190                 1195                 1200             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1205                 1210                 1215             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1220                 1225                 1230             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1235                 1240                 1245             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1250                 1255                 1260             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1265                 1270                 1275             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1280                 1285                 1290             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1295                 1300                 1305             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1310                 1315                 1320             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1325                 1330                 1335             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1340                 1345                 1350             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1370                 1375                 1380             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1385                 1390                 1395             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1400                 1405                 1410             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1415                 1420                 1425             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1430                 1435                 1440             


Gly Gly  Asp Ser Arg Ala Asp  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Ser  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Pro Gly Gly 
    1460                 1465                 1470             


Gly Pro  Ser Ser Gly Ala Pro  Pro Pro Ser Gly Gly  Ser Pro Ala 
    1475                 1480                 1485             


Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr 
    1490                 1495                 1500             


Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 
    1505                 1510                 1515             


Ala Pro  Gly Ser Pro Ala Gly  Ser Pro Thr Ser Thr  Glu Glu Gly 
    1520                 1525                 1530             


Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Thr Ser Thr 
    1535                 1540                 1545             


Glu Pro  Ser Glu Asn His Asp  Gln Glu Phe Asp Pro  Pro Lys Val 
    1550                 1555                 1560             


Tyr Pro  Pro Val Pro Ala Glu  Lys Arg Lys Pro Ile  Arg Val Leu 
    1565                 1570                 1575             


Ser Leu  Phe Asp Gly Ile Ala  Thr Gly Leu Leu Val  Leu Lys Asp 
    1580                 1585                 1590             


Leu Gly  Ile Gln Val Asp Arg  Tyr Ile Ala Ser Glu  Val Cys Glu 
    1595                 1600                 1605             


Asp Ser  Ile Thr Val Gly Met  Val Arg His Gln Gly  Lys Ile Met 
    1610                 1615                 1620             


Tyr Val  Gly Asp Val Arg Ser  Val Thr Gln Lys His  Ile Gln Glu 
    1625                 1630                 1635             


Trp Gly  Pro Phe Asp Leu Val  Ile Gly Gly Ser Pro  Cys Asn Asp 
    1640                 1645                 1650             


Leu Ser  Ile Val Asn Pro Ala  Arg Lys Gly Leu Tyr  Glu Gly Thr 
    1655                 1660                 1665             


Gly Arg  Leu Phe Phe Glu Phe  Tyr Arg Leu Leu His  Asp Ala Arg 
    1670                 1675                 1680             


Pro Lys  Glu Gly Asp Asp Arg  Pro Phe Phe Trp Leu  Phe Glu Asn 
    1685                 1690                 1695             


Val Val  Ala Met Gly Val Ser  Asp Lys Arg Asp Ile  Ser Arg Phe 
    1700                 1705                 1710             


Leu Glu  Ser Asn Pro Val Met  Ile Asp Ala Lys Glu  Val Ser Ala 
    1715                 1720                 1725             


Ala His  Arg Ala Arg Tyr Phe  Trp Gly Asn Leu Pro  Gly Met Asn 
    1730                 1735                 1740             


Arg Pro  Leu Ala Ser Thr Val  Asn Asp Lys Leu Glu  Leu Gln Glu 
    1745                 1750                 1755             


Cys Leu  Glu His Gly Arg Ile  Ala Lys Phe Ser Lys  Val Arg Thr 
    1760                 1765                 1770             


Ile Thr  Thr Arg Ser Asn Ser  Ile Lys Gln Gly Lys  Asp Gln His 
    1775                 1780                 1785             


Phe Pro  Val Phe Met Asn Glu  Lys Glu Asp Ile Leu  Trp Cys Thr 
    1790                 1795                 1800             


Glu Met  Glu Arg Val Phe Gly  Phe Pro Val His Tyr  Thr Asp Val 
    1805                 1810                 1815             


Ser Asn  Met Ser Arg Leu Ala  Arg Gln Arg Leu Leu  Gly Arg Ser 
    1820                 1825                 1830             


Trp Ser  Val Pro Val Ile Arg  His Leu Phe Ala Pro  Leu Lys Glu 
    1835                 1840                 1845             


Tyr Phe  Ala Cys Val Ser Ser  Gly Asn Ser Asn Ala  Asn Ser Arg 
    1850                 1855                 1860             


Gly Pro  Ser Phe Ser Ser Gly  Leu Val Pro Leu Ser  Leu Arg Gly 
    1865                 1870                 1875             


Ser His  Met Gly Pro Met Glu  Ile Tyr Lys Thr Val  Ser Ala Trp 
    1880                 1885                 1890             


Lys Arg  Gln Pro Val Arg Val  Leu Ser Leu Phe Arg  Asn Ile Asp 
    1895                 1900                 1905             


Lys Val  Leu Lys Ser Leu Gly  Phe Leu Glu Ser Gly  Ser Gly Ser 
    1910                 1915                 1920             


Gly Gly  Gly Thr Leu Lys Tyr  Val Glu Asp Val Thr  Asn Val Val 
    1925                 1930                 1935             


Arg Arg  Asp Val Glu Lys Trp  Gly Pro Phe Asp Leu  Val Tyr Gly 
    1940                 1945                 1950             


Ser Thr  Gln Pro Leu Gly Ser  Ser Cys Asp Arg Cys  Pro Gly Trp 
    1955                 1960                 1965             


Tyr Met  Phe Gln Phe His Arg  Ile Leu Gln Tyr Ala  Leu Pro Arg 
    1970                 1975                 1980             


Gln Glu  Ser Gln Arg Pro Phe  Phe Trp Ile Phe Met  Asp Asn Leu 
    1985                 1990                 1995             


Leu Leu  Thr Glu Asp Asp Gln  Glu Thr Thr Thr Arg  Phe Leu Gln 
    2000                 2005                 2010             


Thr Glu  Ala Val Thr Leu Gln  Asp Val Arg Gly Arg  Asp Tyr Gln 
    2015                 2020                 2025             


Asn Ala  Met Arg Val Trp Ser  Asn Ile Pro Gly Leu  Lys Ser Lys 
    2030                 2035                 2040             


His Ala  Pro Leu Thr Pro Lys  Glu Glu Glu Tyr Leu  Gln Ala Gln 
    2045                 2050                 2055             


Val Arg  Ser Arg Ser Lys Leu  Asp Ala Pro Lys Val  Asp Leu Leu 
    2060                 2065                 2070             


Val Lys  Asn Cys Leu Leu Pro  Leu Arg Glu Tyr Phe  Lys Tyr Phe 
    2075                 2080                 2085             


Ser Gln  Asn Ser Leu Pro Leu  Ser Arg Ala Asp Pro  Lys Lys Lys 
    2090                 2095                 2100             


Arg Lys  Val Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2105                 2110                 2115             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Gly Ser  Gly Ala Thr 
    2120                 2125                 2130             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    2135                 2140                 2145             


Gly Pro  Ser Glu Leu Ile Lys  Glu Asn Met His Met  Lys Leu Tyr 
    2150                 2155                 2160             


Met Glu  Gly Thr Val Asp Asn  His His Phe Lys Cys  Thr Ser Glu 
    2165                 2170                 2175             


Gly Glu  Gly Lys Pro Tyr Glu  Gly Thr Gln Thr Met  Arg Ile Lys 
    2180                 2185                 2190             


Val Val  Glu Gly Gly Pro Leu  Pro Phe Ala Phe Asp  Ile Leu Ala 
    2195                 2200                 2205             


Thr Ser  Phe Leu Tyr Gly Ser  Lys Thr Phe Ile Asn  His Thr Gln 
    2210                 2215                 2220             


Gly Ile  Pro Asp Phe Phe Lys  Gln Ser Phe Pro Glu  Gly Phe Thr 
    2225                 2230                 2235             


Trp Glu  Arg Val Thr Thr Tyr  Glu Asp Gly Gly Val  Leu Thr Ala 
    2240                 2245                 2250             


Thr Gln  Asp Thr Ser Leu Gln  Asp Gly Cys Leu Ile  Tyr Asn Val 
    2255                 2260                 2265             


Lys Ile  Arg Gly Val Asn Phe  Thr Ser Asn Gly Pro  Val Met Gln 
    2270                 2275                 2280             


Lys Lys  Thr Leu Gly Trp Glu  Ala Phe Thr Glu Thr  Leu Tyr Pro 
    2285                 2290                 2295             


Ala Asp  Gly Gly Leu Glu Gly  Arg Asn Asp Met Ala  Leu Lys Leu 
    2300                 2305                 2310             


Val Gly  Gly Ser His Leu Ile  Ala Asn Ile Lys Thr  Thr Tyr Arg 
    2315                 2320                 2325             


Ser Lys  Lys Pro Ala Lys Asn  Leu Lys Met Pro Gly  Val Tyr Tyr 
    2330                 2335                 2340             


Val Asp  Tyr Arg Leu Glu Arg  Ile Lys Glu Ala Asn  Asn Glu Thr 
    2345                 2350                 2355             


Tyr Val  Glu Gln His Glu Val  Ala Val Ala Arg Tyr  Cys Asp Leu 
    2360                 2365                 2370             


Pro Ser  Lys Leu Gly His Lys  Leu Asn 
    2375                 2380         


<210>  7
<211>  2303
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Ser Gly Ser Glu Thr Pro Gly Thr Ser 
65                  70                  75                  80  


Glu Ser Ala Thr Pro Glu Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu 
                85                  90                  95      


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            100                 105                 110         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        115                 120                 125             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    130                 135                 140                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
145                 150                 155                 160 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                165                 170                 175     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            180                 185                 190         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        195                 200                 205             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    210                 215                 220                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
225                 230                 235                 240 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                245                 250                 255     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            260                 265                 270         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        275                 280                 285             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    290                 295                 300                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
305                 310                 315                 320 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                325                 330                 335     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            340                 345                 350         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        355                 360                 365             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    370                 375                 380                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
385                 390                 395                 400 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                405                 410                 415     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            420                 425                 430         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        435                 440                 445             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    450                 455                 460                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
465                 470                 475                 480 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                485                 490                 495     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            500                 505                 510         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        515                 520                 525             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    530                 535                 540                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
545                 550                 555                 560 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                565                 570                 575     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            580                 585                 590         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        595                 600                 605             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    610                 615                 620                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
625                 630                 635                 640 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                645                 650                 655     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            660                 665                 670         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        675                 680                 685             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    690                 695                 700                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
705                 710                 715                 720 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                725                 730                 735     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            740                 745                 750         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        755                 760                 765             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    770                 775                 780                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
785                 790                 795                 800 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                805                 810                 815     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            820                 825                 830         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        835                 840                 845             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    850                 855                 860                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
865                 870                 875                 880 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                885                 890                 895     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            900                 905                 910         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
        915                 920                 925             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    930                 935                 940                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
945                 950                 955                 960 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                965                 970                 975     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            980                 985                 990         


Gly Gly Leu Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
        995                 1000                 1005             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1010                 1015                 1020             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1025                 1030                 1035             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1040                 1045                 1050             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1055                 1060                 1065             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1070                 1075                 1080             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1085                 1090                 1095             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1100                 1105                 1110             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1115                 1120                 1125             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1130                 1135                 1140             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1145                 1150                 1155             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1160                 1165                 1170             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1175                 1180                 1185             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1190                 1195                 1200             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1205                 1210                 1215             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1220                 1225                 1230             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1235                 1240                 1245             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1250                 1255                 1260             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1265                 1270                 1275             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1280                 1285                 1290             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1295                 1300                 1305             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1325                 1330                 1335             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1340                 1345                 1350             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1355                 1360                 1365             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1370                 1375                 1380             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1385                 1390                 1395             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1400                 1405                 1410             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1415                 1420                 1425             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1430                 1435                 1440             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Arg Ala 
    1445                 1450                 1455             


Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Ser Gly  Ser Pro Lys 
    1460                 1465                 1470             


Lys Lys  Arg Lys Val Glu Ala  Ser Gly Ser Gly Arg  Ala Ser Pro 
    1475                 1480                 1485             


Gly Ile  Pro Gly Ser Thr Arg  Asn His Asp Gln Glu  Phe Asp Pro 
    1490                 1495                 1500             


Pro Lys  Val Tyr Pro Pro Val  Pro Ala Glu Lys Arg  Lys Pro Ile 
    1505                 1510                 1515             


Arg Val  Leu Ser Leu Phe Asp  Gly Ile Ala Thr Gly  Leu Leu Val 
    1520                 1525                 1530             


Leu Lys  Asp Leu Gly Ile Gln  Val Asp Arg Tyr Ile  Ala Ser Glu 
    1535                 1540                 1545             


Val Cys  Glu Asp Ser Ile Thr  Val Gly Met Val Arg  His Gln Gly 
    1550                 1555                 1560             


Lys Ile  Met Tyr Val Gly Asp  Val Arg Ser Val Thr  Gln Lys His 
    1565                 1570                 1575             


Ile Gln  Glu Trp Gly Pro Phe  Asp Leu Val Ile Gly  Gly Ser Pro 
    1580                 1585                 1590             


Cys Asn  Asp Leu Ser Ile Val  Asn Pro Ala Arg Lys  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Gly  Thr Gly Arg Leu Phe  Phe Glu Phe Tyr Arg  Leu Leu His 
    1610                 1615                 1620             


Asp Ala  Arg Pro Lys Glu Gly  Asp Asp Arg Pro Phe  Phe Trp Leu 
    1625                 1630                 1635             


Phe Glu  Asn Val Val Ala Met  Gly Val Ser Asp Lys  Arg Asp Ile 
    1640                 1645                 1650             


Ser Arg  Phe Leu Glu Ser Asn  Pro Val Met Ile Asp  Ala Lys Glu 
    1655                 1660                 1665             


Val Ser  Ala Ala His Arg Ala  Arg Tyr Phe Trp Gly  Asn Leu Pro 
    1670                 1675                 1680             


Gly Met  Asn Arg Pro Leu Ala  Ser Thr Val Asn Asp  Lys Leu Glu 
    1685                 1690                 1695             


Leu Gln  Glu Cys Leu Glu His  Gly Arg Ile Ala Lys  Phe Ser Lys 
    1700                 1705                 1710             


Val Arg  Thr Ile Thr Thr Arg  Ser Asn Ser Ile Lys  Gln Gly Lys 
    1715                 1720                 1725             


Asp Gln  His Phe Pro Val Phe  Met Asn Glu Lys Glu  Asp Ile Leu 
    1730                 1735                 1740             


Trp Cys  Thr Glu Met Glu Arg  Val Phe Gly Phe Pro  Val His Tyr 
    1745                 1750                 1755             


Thr Asp  Val Ser Asn Met Ser  Arg Leu Ala Arg Gln  Arg Leu Leu 
    1760                 1765                 1770             


Gly Arg  Ser Trp Ser Val Pro  Val Ile Arg His Leu  Phe Ala Pro 
    1775                 1780                 1785             


Leu Lys  Glu Tyr Phe Ala Cys  Val Ser Ser Gly Asn  Ser Asn Ala 
    1790                 1795                 1800             


Asn Ser  Arg Gly Pro Ser Phe  Ser Ser Gly Leu Val  Pro Leu Ser 
    1805                 1810                 1815             


Leu Arg  Gly Ser His Met Gly  Pro Met Glu Ile Tyr  Lys Thr Val 
    1820                 1825                 1830             


Ser Ala  Trp Lys Arg Gln Pro  Val Arg Val Leu Ser  Leu Phe Arg 
    1835                 1840                 1845             


Asn Ile  Asp Lys Val Leu Lys  Ser Leu Gly Phe Leu  Glu Ser Gly 
    1850                 1855                 1860             


Ser Gly  Ser Gly Gly Gly Thr  Leu Lys Tyr Val Glu  Asp Val Thr 
    1865                 1870                 1875             


Asn Val  Val Arg Arg Asp Val  Glu Lys Trp Gly Pro  Phe Asp Leu 
    1880                 1885                 1890             


Val Tyr  Gly Ser Thr Gln Pro  Leu Gly Ser Ser Cys  Asp Arg Cys 
    1895                 1900                 1905             


Pro Gly  Trp Tyr Met Phe Gln  Phe His Arg Ile Leu  Gln Tyr Ala 
    1910                 1915                 1920             


Leu Pro  Arg Gln Glu Ser Gln  Arg Pro Phe Phe Trp  Ile Phe Met 
    1925                 1930                 1935             


Asp Asn  Leu Leu Leu Thr Glu  Asp Asp Gln Glu Thr  Thr Thr Arg 
    1940                 1945                 1950             


Phe Leu  Gln Thr Glu Ala Val  Thr Leu Gln Asp Val  Arg Gly Arg 
    1955                 1960                 1965             


Asp Tyr  Gln Asn Ala Met Arg  Val Trp Ser Asn Ile  Pro Gly Leu 
    1970                 1975                 1980             


Lys Ser  Lys His Ala Pro Leu  Thr Pro Lys Glu Glu  Glu Tyr Leu 
    1985                 1990                 1995             


Gln Ala  Gln Val Arg Ser Arg  Ser Lys Leu Asp Ala  Pro Lys Val 
    2000                 2005                 2010             


Asp Leu  Leu Val Lys Asn Cys  Leu Leu Pro Leu Arg  Glu Tyr Phe 
    2015                 2020                 2025             


Lys Tyr  Phe Ser Gln Asn Ser  Leu Pro Leu Ser Arg  Ala Asp Pro 
    2030                 2035                 2040             


Lys Lys  Lys Arg Lys Val Gly  Ser Gly Ala Thr Asn  Phe Ser Leu 
    2045                 2050                 2055             


Leu Lys  Gln Ala Gly Asp Val  Glu Glu Asn Pro Gly  Pro Ser Glu 
    2060                 2065                 2070             


Leu Ile  Lys Glu Asn Met His  Met Lys Leu Tyr Met  Glu Gly Thr 
    2075                 2080                 2085             


Val Asp  Asn His His Phe Lys  Cys Thr Ser Glu Gly  Glu Gly Lys 
    2090                 2095                 2100             


Pro Tyr  Glu Gly Thr Gln Thr  Met Arg Ile Lys Val  Val Glu Gly 
    2105                 2110                 2115             


Gly Pro  Leu Pro Phe Ala Phe  Asp Ile Leu Ala Thr  Ser Phe Leu 
    2120                 2125                 2130             


Tyr Gly  Ser Lys Thr Phe Ile  Asn His Thr Gln Gly  Ile Pro Asp 
    2135                 2140                 2145             


Phe Phe  Lys Gln Ser Phe Pro  Glu Gly Phe Thr Trp  Glu Arg Val 
    2150                 2155                 2160             


Thr Thr  Tyr Glu Asp Gly Gly  Val Leu Thr Ala Thr  Gln Asp Thr 
    2165                 2170                 2175             


Ser Leu  Gln Asp Gly Cys Leu  Ile Tyr Asn Val Lys  Ile Arg Gly 
    2180                 2185                 2190             


Val Asn  Phe Thr Ser Asn Gly  Pro Val Met Gln Lys  Lys Thr Leu 
    2195                 2200                 2205             


Gly Trp  Glu Ala Phe Thr Glu  Thr Leu Tyr Pro Ala  Asp Gly Gly 
    2210                 2215                 2220             


Leu Glu  Gly Arg Asn Asp Met  Ala Leu Lys Leu Val  Gly Gly Ser 
    2225                 2230                 2235             


His Leu  Ile Ala Asn Ile Lys  Thr Thr Tyr Arg Ser  Lys Lys Pro 
    2240                 2245                 2250             


Ala Lys  Asn Leu Lys Met Pro  Gly Val Tyr Tyr Val  Asp Tyr Arg 
    2255                 2260                 2265             


Leu Glu  Arg Ile Lys Glu Ala  Asn Asn Glu Thr Tyr  Val Glu Gln 
    2270                 2275                 2280             


His Glu  Val Ala Val Ala Arg  Tyr Cys Asp Leu Pro  Ser Lys Leu 
    2285                 2290                 2295             


Gly His  Lys Leu Asn 
    2300             


<210>  8
<211>  2325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Ser Gly Ser Glu Thr Pro Gly Thr Ser 
65                  70                  75                  80  


Glu Ser Ala Thr Pro Glu Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu 
                85                  90                  95      


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            100                 105                 110         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        115                 120                 125             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    130                 135                 140                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
145                 150                 155                 160 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                165                 170                 175     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            180                 185                 190         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        195                 200                 205             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    210                 215                 220                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
225                 230                 235                 240 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                245                 250                 255     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            260                 265                 270         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        275                 280                 285             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    290                 295                 300                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
305                 310                 315                 320 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                325                 330                 335     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            340                 345                 350         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        355                 360                 365             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    370                 375                 380                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
385                 390                 395                 400 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                405                 410                 415     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            420                 425                 430         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        435                 440                 445             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    450                 455                 460                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
465                 470                 475                 480 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                485                 490                 495     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            500                 505                 510         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        515                 520                 525             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    530                 535                 540                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
545                 550                 555                 560 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                565                 570                 575     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            580                 585                 590         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        595                 600                 605             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    610                 615                 620                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
625                 630                 635                 640 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                645                 650                 655     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            660                 665                 670         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        675                 680                 685             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    690                 695                 700                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
705                 710                 715                 720 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                725                 730                 735     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            740                 745                 750         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        755                 760                 765             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    770                 775                 780                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
785                 790                 795                 800 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                805                 810                 815     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            820                 825                 830         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        835                 840                 845             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    850                 855                 860                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
865                 870                 875                 880 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                885                 890                 895     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            900                 905                 910         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
        915                 920                 925             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    930                 935                 940                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
945                 950                 955                 960 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                965                 970                 975     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            980                 985                 990         


Gly Gly Leu Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
        995                 1000                 1005             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1010                 1015                 1020             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1025                 1030                 1035             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1040                 1045                 1050             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1055                 1060                 1065             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1070                 1075                 1080             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1085                 1090                 1095             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1100                 1105                 1110             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1115                 1120                 1125             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1130                 1135                 1140             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1145                 1150                 1155             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1160                 1165                 1170             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1175                 1180                 1185             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1190                 1195                 1200             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1205                 1210                 1215             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1220                 1225                 1230             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1235                 1240                 1245             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1250                 1255                 1260             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1265                 1270                 1275             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1280                 1285                 1290             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1295                 1300                 1305             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1325                 1330                 1335             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1340                 1345                 1350             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1355                 1360                 1365             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1370                 1375                 1380             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1385                 1390                 1395             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1400                 1405                 1410             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1415                 1420                 1425             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1430                 1435                 1440             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Arg Ala 
    1445                 1450                 1455             


Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Ser Gly  Ser Pro Lys 
    1460                 1465                 1470             


Lys Lys  Arg Lys Val Glu Ala  Ser Gly Ser Gly Arg  Ala Ser Pro 
    1475                 1480                 1485             


Gly Ile  Pro Gly Ser Thr Arg  Asn His Asp Gln Glu  Phe Asp Pro 
    1490                 1495                 1500             


Pro Lys  Val Tyr Pro Pro Val  Pro Ala Glu Lys Arg  Lys Pro Ile 
    1505                 1510                 1515             


Arg Val  Leu Ser Leu Phe Asp  Gly Ile Ala Thr Gly  Leu Leu Val 
    1520                 1525                 1530             


Leu Lys  Asp Leu Gly Ile Gln  Val Asp Arg Tyr Ile  Ala Ser Glu 
    1535                 1540                 1545             


Val Cys  Glu Asp Ser Ile Thr  Val Gly Met Val Arg  His Gln Gly 
    1550                 1555                 1560             


Lys Ile  Met Tyr Val Gly Asp  Val Arg Ser Val Thr  Gln Lys His 
    1565                 1570                 1575             


Ile Gln  Glu Trp Gly Pro Phe  Asp Leu Val Ile Gly  Gly Ser Pro 
    1580                 1585                 1590             


Cys Asn  Asp Leu Ser Ile Val  Asn Pro Ala Arg Lys  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Gly  Thr Gly Arg Leu Phe  Phe Glu Phe Tyr Arg  Leu Leu His 
    1610                 1615                 1620             


Asp Ala  Arg Pro Lys Glu Gly  Asp Asp Arg Pro Phe  Phe Trp Leu 
    1625                 1630                 1635             


Phe Glu  Asn Val Val Ala Met  Gly Val Ser Asp Lys  Arg Asp Ile 
    1640                 1645                 1650             


Ser Arg  Phe Leu Glu Ser Asn  Pro Val Met Ile Asp  Ala Lys Glu 
    1655                 1660                 1665             


Val Ser  Ala Ala His Arg Ala  Arg Tyr Phe Trp Gly  Asn Leu Pro 
    1670                 1675                 1680             


Gly Met  Asn Arg Pro Leu Ala  Ser Thr Val Asn Asp  Lys Leu Glu 
    1685                 1690                 1695             


Leu Gln  Glu Cys Leu Glu His  Gly Arg Ile Ala Lys  Phe Ser Lys 
    1700                 1705                 1710             


Val Arg  Thr Ile Thr Thr Arg  Ser Asn Ser Ile Lys  Gln Gly Lys 
    1715                 1720                 1725             


Asp Gln  His Phe Pro Val Phe  Met Asn Glu Lys Glu  Asp Ile Leu 
    1730                 1735                 1740             


Trp Cys  Thr Glu Met Glu Arg  Val Phe Gly Phe Pro  Val His Tyr 
    1745                 1750                 1755             


Thr Asp  Val Ser Asn Met Ser  Arg Leu Ala Arg Gln  Arg Leu Leu 
    1760                 1765                 1770             


Gly Arg  Ser Trp Ser Val Pro  Val Ile Arg His Leu  Phe Ala Pro 
    1775                 1780                 1785             


Leu Lys  Glu Tyr Phe Ala Cys  Val Ser Ser Gly Asn  Ser Asn Ala 
    1790                 1795                 1800             


Asn Ser  Arg Gly Pro Ser Phe  Ser Ser Gly Leu Val  Pro Leu Ser 
    1805                 1810                 1815             


Leu Arg  Gly Ser His Met Gly  Pro Met Glu Ile Tyr  Lys Thr Val 
    1820                 1825                 1830             


Ser Ala  Trp Lys Arg Gln Pro  Val Arg Val Leu Ser  Leu Phe Arg 
    1835                 1840                 1845             


Asn Ile  Asp Lys Val Leu Lys  Ser Leu Gly Phe Leu  Glu Ser Gly 
    1850                 1855                 1860             


Ser Gly  Ser Gly Gly Gly Thr  Leu Lys Tyr Val Glu  Asp Val Thr 
    1865                 1870                 1875             


Asn Val  Val Arg Arg Asp Val  Glu Lys Trp Gly Pro  Phe Asp Leu 
    1880                 1885                 1890             


Val Tyr  Gly Ser Thr Gln Pro  Leu Gly Ser Ser Cys  Asp Arg Cys 
    1895                 1900                 1905             


Pro Gly  Trp Tyr Met Phe Gln  Phe His Arg Ile Leu  Gln Tyr Ala 
    1910                 1915                 1920             


Leu Pro  Arg Gln Glu Ser Gln  Arg Pro Phe Phe Trp  Ile Phe Met 
    1925                 1930                 1935             


Asp Asn  Leu Leu Leu Thr Glu  Asp Asp Gln Glu Thr  Thr Thr Arg 
    1940                 1945                 1950             


Phe Leu  Gln Thr Glu Ala Val  Thr Leu Gln Asp Val  Arg Gly Arg 
    1955                 1960                 1965             


Asp Tyr  Gln Asn Ala Met Arg  Val Trp Ser Asn Ile  Pro Gly Leu 
    1970                 1975                 1980             


Lys Ser  Lys His Ala Pro Leu  Thr Pro Lys Glu Glu  Glu Tyr Leu 
    1985                 1990                 1995             


Gln Ala  Gln Val Arg Ser Arg  Ser Lys Leu Asp Ala  Pro Lys Val 
    2000                 2005                 2010             


Asp Leu  Leu Val Lys Asn Cys  Leu Leu Pro Leu Arg  Glu Tyr Phe 
    2015                 2020                 2025             


Lys Tyr  Phe Ser Gln Asn Ser  Leu Pro Leu Ser Arg  Ala Asp Pro 
    2030                 2035                 2040             


Lys Lys  Lys Arg Lys Val Gly  Ser Gly Ala Thr Asn  Phe Ser Leu 
    2045                 2050                 2055             


Leu Lys  Gln Ala Gly Asp Val  Glu Glu Asn Pro Gly  Pro Gly Ser 
    2060                 2065                 2070             


Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln Ala Gly  Asp Val Glu 
    2075                 2080                 2085             


Glu Asn  Pro Gly Pro Ser Glu  Leu Ile Lys Glu Asn  Met His Met 
    2090                 2095                 2100             


Lys Leu  Tyr Met Glu Gly Thr  Val Asp Asn His His  Phe Lys Cys 
    2105                 2110                 2115             


Thr Ser  Glu Gly Glu Gly Lys  Pro Tyr Glu Gly Thr  Gln Thr Met 
    2120                 2125                 2130             


Arg Ile  Lys Val Val Glu Gly  Gly Pro Leu Pro Phe  Ala Phe Asp 
    2135                 2140                 2145             


Ile Leu  Ala Thr Ser Phe Leu  Tyr Gly Ser Lys Thr  Phe Ile Asn 
    2150                 2155                 2160             


His Thr  Gln Gly Ile Pro Asp  Phe Phe Lys Gln Ser  Phe Pro Glu 
    2165                 2170                 2175             


Gly Phe  Thr Trp Glu Arg Val  Thr Thr Tyr Glu Asp  Gly Gly Val 
    2180                 2185                 2190             


Leu Thr  Ala Thr Gln Asp Thr  Ser Leu Gln Asp Gly  Cys Leu Ile 
    2195                 2200                 2205             


Tyr Asn  Val Lys Ile Arg Gly  Val Asn Phe Thr Ser  Asn Gly Pro 
    2210                 2215                 2220             


Val Met  Gln Lys Lys Thr Leu  Gly Trp Glu Ala Phe  Thr Glu Thr 
    2225                 2230                 2235             


Leu Tyr  Pro Ala Asp Gly Gly  Leu Glu Gly Arg Asn  Asp Met Ala 
    2240                 2245                 2250             


Leu Lys  Leu Val Gly Gly Ser  His Leu Ile Ala Asn  Ile Lys Thr 
    2255                 2260                 2265             


Thr Tyr  Arg Ser Lys Lys Pro  Ala Lys Asn Leu Lys  Met Pro Gly 
    2270                 2275                 2280             


Val Tyr  Tyr Val Asp Tyr Arg  Leu Glu Arg Ile Lys  Glu Ala Asn 
    2285                 2290                 2295             


Asn Glu  Thr Tyr Val Glu Gln  His Glu Val Ala Val  Ala Arg Tyr 
    2300                 2305                 2310             


Cys Asp  Leu Pro Ser Lys Leu  Gly His Lys Leu Asn  
    2315                 2320                 2325 


<210>  9
<211>  2367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Pro Ser Ser Gly Ala Pro Pro 
65                  70                  75                  80  


Pro Ser Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


Thr Ser Thr Glu Pro Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu 
145                 150                 155                 160 


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
                165                 170                 175     


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
            180                 185                 190         


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
        195                 200                 205             


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
    210                 215                 220                 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
225                 230                 235                 240 


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
                245                 250                 255     


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
            260                 265                 270         


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
        275                 280                 285             


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
    290                 295                 300                 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
305                 310                 315                 320 


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
                325                 330                 335     


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
            340                 345                 350         


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
        355                 360                 365             


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
    370                 375                 380                 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
385                 390                 395                 400 


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
                405                 410                 415     


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
            420                 425                 430         


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
        435                 440                 445             


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
    450                 455                 460                 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
465                 470                 475                 480 


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
                485                 490                 495     


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
            500                 505                 510         


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
        515                 520                 525             


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
    530                 535                 540                 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
545                 550                 555                 560 


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
                565                 570                 575     


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
            580                 585                 590         


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
        595                 600                 605             


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
    610                 615                 620                 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
625                 630                 635                 640 


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
                645                 650                 655     


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
            660                 665                 670         


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
        675                 680                 685             


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
    690                 695                 700                 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
705                 710                 715                 720 


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
                725                 730                 735     


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
            740                 745                 750         


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
        755                 760                 765             


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
    770                 775                 780                 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
785                 790                 795                 800 


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
                805                 810                 815     


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
            820                 825                 830         


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
        835                 840                 845             


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
    850                 855                 860                 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
865                 870                 875                 880 


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
                885                 890                 895     


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
            900                 905                 910         


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
        915                 920                 925             


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
    930                 935                 940                 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
945                 950                 955                 960 


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
                965                 970                 975     


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
            980                 985                 990         


Val Pro Gln Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
        995                 1000                 1005             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1010                 1015                 1020             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1025                 1030                 1035             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1040                 1045                 1050             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1055                 1060                 1065             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1070                 1075                 1080             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1085                 1090                 1095             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1100                 1105                 1110             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1115                 1120                 1125             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1130                 1135                 1140             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1145                 1150                 1155             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1160                 1165                 1170             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1175                 1180                 1185             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1190                 1195                 1200             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1205                 1210                 1215             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1220                 1225                 1230             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1235                 1240                 1245             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1250                 1255                 1260             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1265                 1270                 1275             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1280                 1285                 1290             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1295                 1300                 1305             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1310                 1315                 1320             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1325                 1330                 1335             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1340                 1345                 1350             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1355                 1360                 1365             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1370                 1375                 1380             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1385                 1390                 1395             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1400                 1405                 1410             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1415                 1420                 1425             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1430                 1435                 1440             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1460                 1465                 1470             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1475                 1480                 1485             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1490                 1495                 1500             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1505                 1510                 1515             


Asp Ser  Arg Ala Asp Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Ser 
    1520                 1525                 1530             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Glu Ala Ser  Gly Ser Gly 
    1535                 1540                 1545             


Arg Ala  Ser Pro Gly Ile Pro  Gly Ser Thr Arg Asn  His Asp Gln 
    1550                 1555                 1560             


Glu Phe  Asp Pro Pro Lys Val  Tyr Pro Pro Val Pro  Ala Glu Lys 
    1565                 1570                 1575             


Arg Lys  Pro Ile Arg Val Leu  Ser Leu Phe Asp Gly  Ile Ala Thr 
    1580                 1585                 1590             


Gly Leu  Leu Val Leu Lys Asp  Leu Gly Ile Gln Val  Asp Arg Tyr 
    1595                 1600                 1605             


Ile Ala  Ser Glu Val Cys Glu  Asp Ser Ile Thr Val  Gly Met Val 
    1610                 1615                 1620             


Arg His  Gln Gly Lys Ile Met  Tyr Val Gly Asp Val  Arg Ser Val 
    1625                 1630                 1635             


Thr Gln  Lys His Ile Gln Glu  Trp Gly Pro Phe Asp  Leu Val Ile 
    1640                 1645                 1650             


Gly Gly  Ser Pro Cys Asn Asp  Leu Ser Ile Val Asn  Pro Ala Arg 
    1655                 1660                 1665             


Lys Gly  Leu Tyr Glu Gly Thr  Gly Arg Leu Phe Phe  Glu Phe Tyr 
    1670                 1675                 1680             


Arg Leu  Leu His Asp Ala Arg  Pro Lys Glu Gly Asp  Asp Arg Pro 
    1685                 1690                 1695             


Phe Phe  Trp Leu Phe Glu Asn  Val Val Ala Met Gly  Val Ser Asp 
    1700                 1705                 1710             


Lys Arg  Asp Ile Ser Arg Phe  Leu Glu Ser Asn Pro  Val Met Ile 
    1715                 1720                 1725             


Asp Ala  Lys Glu Val Ser Ala  Ala His Arg Ala Arg  Tyr Phe Trp 
    1730                 1735                 1740             


Gly Asn  Leu Pro Gly Met Asn  Arg Pro Leu Ala Ser  Thr Val Asn 
    1745                 1750                 1755             


Asp Lys  Leu Glu Leu Gln Glu  Cys Leu Glu His Gly  Arg Ile Ala 
    1760                 1765                 1770             


Lys Phe  Ser Lys Val Arg Thr  Ile Thr Thr Arg Ser  Asn Ser Ile 
    1775                 1780                 1785             


Lys Gln  Gly Lys Asp Gln His  Phe Pro Val Phe Met  Asn Glu Lys 
    1790                 1795                 1800             


Glu Asp  Ile Leu Trp Cys Thr  Glu Met Glu Arg Val  Phe Gly Phe 
    1805                 1810                 1815             


Pro Val  His Tyr Thr Asp Val  Ser Asn Met Ser Arg  Leu Ala Arg 
    1820                 1825                 1830             


Gln Arg  Leu Leu Gly Arg Ser  Trp Ser Val Pro Val  Ile Arg His 
    1835                 1840                 1845             


Leu Phe  Ala Pro Leu Lys Glu  Tyr Phe Ala Cys Val  Ser Ser Gly 
    1850                 1855                 1860             


Asn Ser  Asn Ala Asn Ser Arg  Gly Pro Ser Phe Ser  Ser Gly Leu 
    1865                 1870                 1875             


Val Pro  Leu Ser Leu Arg Gly  Ser His Met Gly Pro  Met Glu Ile 
    1880                 1885                 1890             


Tyr Lys  Thr Val Ser Ala Trp  Lys Arg Gln Pro Val  Arg Val Leu 
    1895                 1900                 1905             


Ser Leu  Phe Arg Asn Ile Asp  Lys Val Leu Lys Ser  Leu Gly Phe 
    1910                 1915                 1920             


Leu Glu  Ser Gly Ser Gly Ser  Gly Gly Gly Thr Leu  Lys Tyr Val 
    1925                 1930                 1935             


Glu Asp  Val Thr Asn Val Val  Arg Arg Asp Val Glu  Lys Trp Gly 
    1940                 1945                 1950             


Pro Phe  Asp Leu Val Tyr Gly  Ser Thr Gln Pro Leu  Gly Ser Ser 
    1955                 1960                 1965             


Cys Asp  Arg Cys Pro Gly Trp  Tyr Met Phe Gln Phe  His Arg Ile 
    1970                 1975                 1980             


Leu Gln  Tyr Ala Leu Pro Arg  Gln Glu Ser Gln Arg  Pro Phe Phe 
    1985                 1990                 1995             


Trp Ile  Phe Met Asp Asn Leu  Leu Leu Thr Glu Asp  Asp Gln Glu 
    2000                 2005                 2010             


Thr Thr  Thr Arg Phe Leu Gln  Thr Glu Ala Val Thr  Leu Gln Asp 
    2015                 2020                 2025             


Val Arg  Gly Arg Asp Tyr Gln  Asn Ala Met Arg Val  Trp Ser Asn 
    2030                 2035                 2040             


Ile Pro  Gly Leu Lys Ser Lys  His Ala Pro Leu Thr  Pro Lys Glu 
    2045                 2050                 2055             


Glu Glu  Tyr Leu Gln Ala Gln  Val Arg Ser Arg Ser  Lys Leu Asp 
    2060                 2065                 2070             


Ala Pro  Lys Val Asp Leu Leu  Val Lys Asn Cys Leu  Leu Pro Leu 
    2075                 2080                 2085             


Arg Glu  Tyr Phe Lys Tyr Phe  Ser Gln Asn Ser Leu  Pro Leu Ser 
    2090                 2095                 2100             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Ala Thr 
    2105                 2110                 2115             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    2120                 2125                 2130             


Gly Pro  Ser Glu Leu Ile Lys  Glu Asn Met His Met  Lys Leu Tyr 
    2135                 2140                 2145             


Met Glu  Gly Thr Val Asp Asn  His His Phe Lys Cys  Thr Ser Glu 
    2150                 2155                 2160             


Gly Glu  Gly Lys Pro Tyr Glu  Gly Thr Gln Thr Met  Arg Ile Lys 
    2165                 2170                 2175             


Val Val  Glu Gly Gly Pro Leu  Pro Phe Ala Phe Asp  Ile Leu Ala 
    2180                 2185                 2190             


Thr Ser  Phe Leu Tyr Gly Ser  Lys Thr Phe Ile Asn  His Thr Gln 
    2195                 2200                 2205             


Gly Ile  Pro Asp Phe Phe Lys  Gln Ser Phe Pro Glu  Gly Phe Thr 
    2210                 2215                 2220             


Trp Glu  Arg Val Thr Thr Tyr  Glu Asp Gly Gly Val  Leu Thr Ala 
    2225                 2230                 2235             


Thr Gln  Asp Thr Ser Leu Gln  Asp Gly Cys Leu Ile  Tyr Asn Val 
    2240                 2245                 2250             


Lys Ile  Arg Gly Val Asn Phe  Thr Ser Asn Gly Pro  Val Met Gln 
    2255                 2260                 2265             


Lys Lys  Thr Leu Gly Trp Glu  Ala Phe Thr Glu Thr  Leu Tyr Pro 
    2270                 2275                 2280             


Ala Asp  Gly Gly Leu Glu Gly  Arg Asn Asp Met Ala  Leu Lys Leu 
    2285                 2290                 2295             


Val Gly  Gly Ser His Leu Ile  Ala Asn Ile Lys Thr  Thr Tyr Arg 
    2300                 2305                 2310             


Ser Lys  Lys Pro Ala Lys Asn  Leu Lys Met Pro Gly  Val Tyr Tyr 
    2315                 2320                 2325             


Val Asp  Tyr Arg Leu Glu Arg  Ile Lys Glu Ala Asn  Asn Glu Thr 
    2330                 2335                 2340             


Tyr Val  Glu Gln His Glu Val  Ala Val Ala Arg Tyr  Cys Asp Leu 
    2345                 2350                 2355             


Pro Ser  Lys Leu Gly His Lys  Leu Asn 
    2360                 2365         


<210>  10
<211>  2389
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Pro Ser Ser Gly Ala Pro Pro 
65                  70                  75                  80  


Pro Ser Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


Thr Ser Thr Glu Pro Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu 
145                 150                 155                 160 


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
                165                 170                 175     


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
            180                 185                 190         


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
        195                 200                 205             


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
    210                 215                 220                 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
225                 230                 235                 240 


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
                245                 250                 255     


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
            260                 265                 270         


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
        275                 280                 285             


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
    290                 295                 300                 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
305                 310                 315                 320 


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
                325                 330                 335     


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
            340                 345                 350         


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
        355                 360                 365             


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
    370                 375                 380                 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
385                 390                 395                 400 


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
                405                 410                 415     


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
            420                 425                 430         


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
        435                 440                 445             


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
    450                 455                 460                 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
465                 470                 475                 480 


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
                485                 490                 495     


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
            500                 505                 510         


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
        515                 520                 525             


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
    530                 535                 540                 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
545                 550                 555                 560 


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
                565                 570                 575     


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
            580                 585                 590         


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
        595                 600                 605             


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
    610                 615                 620                 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
625                 630                 635                 640 


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
                645                 650                 655     


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
            660                 665                 670         


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
        675                 680                 685             


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
    690                 695                 700                 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
705                 710                 715                 720 


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
                725                 730                 735     


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
            740                 745                 750         


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
        755                 760                 765             


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
    770                 775                 780                 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
785                 790                 795                 800 


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
                805                 810                 815     


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
            820                 825                 830         


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
        835                 840                 845             


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
    850                 855                 860                 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
865                 870                 875                 880 


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
                885                 890                 895     


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
            900                 905                 910         


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
        915                 920                 925             


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
    930                 935                 940                 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
945                 950                 955                 960 


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
                965                 970                 975     


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
            980                 985                 990         


Val Pro Gln Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
        995                 1000                 1005             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1010                 1015                 1020             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1025                 1030                 1035             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1040                 1045                 1050             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1055                 1060                 1065             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1070                 1075                 1080             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1085                 1090                 1095             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1100                 1105                 1110             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1115                 1120                 1125             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1130                 1135                 1140             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1145                 1150                 1155             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1160                 1165                 1170             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1175                 1180                 1185             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1190                 1195                 1200             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1205                 1210                 1215             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1220                 1225                 1230             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1235                 1240                 1245             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1250                 1255                 1260             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1265                 1270                 1275             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1280                 1285                 1290             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1295                 1300                 1305             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1310                 1315                 1320             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1325                 1330                 1335             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1340                 1345                 1350             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1355                 1360                 1365             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1370                 1375                 1380             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1385                 1390                 1395             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1400                 1405                 1410             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1415                 1420                 1425             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1430                 1435                 1440             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1460                 1465                 1470             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1475                 1480                 1485             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1490                 1495                 1500             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1505                 1510                 1515             


Asp Ser  Arg Ala Asp Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Ser 
    1520                 1525                 1530             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Glu Ala Ser  Gly Ser Gly 
    1535                 1540                 1545             


Arg Ala  Ser Pro Gly Ile Pro  Gly Ser Thr Arg Asn  His Asp Gln 
    1550                 1555                 1560             


Glu Phe  Asp Pro Pro Lys Val  Tyr Pro Pro Val Pro  Ala Glu Lys 
    1565                 1570                 1575             


Arg Lys  Pro Ile Arg Val Leu  Ser Leu Phe Asp Gly  Ile Ala Thr 
    1580                 1585                 1590             


Gly Leu  Leu Val Leu Lys Asp  Leu Gly Ile Gln Val  Asp Arg Tyr 
    1595                 1600                 1605             


Ile Ala  Ser Glu Val Cys Glu  Asp Ser Ile Thr Val  Gly Met Val 
    1610                 1615                 1620             


Arg His  Gln Gly Lys Ile Met  Tyr Val Gly Asp Val  Arg Ser Val 
    1625                 1630                 1635             


Thr Gln  Lys His Ile Gln Glu  Trp Gly Pro Phe Asp  Leu Val Ile 
    1640                 1645                 1650             


Gly Gly  Ser Pro Cys Asn Asp  Leu Ser Ile Val Asn  Pro Ala Arg 
    1655                 1660                 1665             


Lys Gly  Leu Tyr Glu Gly Thr  Gly Arg Leu Phe Phe  Glu Phe Tyr 
    1670                 1675                 1680             


Arg Leu  Leu His Asp Ala Arg  Pro Lys Glu Gly Asp  Asp Arg Pro 
    1685                 1690                 1695             


Phe Phe  Trp Leu Phe Glu Asn  Val Val Ala Met Gly  Val Ser Asp 
    1700                 1705                 1710             


Lys Arg  Asp Ile Ser Arg Phe  Leu Glu Ser Asn Pro  Val Met Ile 
    1715                 1720                 1725             


Asp Ala  Lys Glu Val Ser Ala  Ala His Arg Ala Arg  Tyr Phe Trp 
    1730                 1735                 1740             


Gly Asn  Leu Pro Gly Met Asn  Arg Pro Leu Ala Ser  Thr Val Asn 
    1745                 1750                 1755             


Asp Lys  Leu Glu Leu Gln Glu  Cys Leu Glu His Gly  Arg Ile Ala 
    1760                 1765                 1770             


Lys Phe  Ser Lys Val Arg Thr  Ile Thr Thr Arg Ser  Asn Ser Ile 
    1775                 1780                 1785             


Lys Gln  Gly Lys Asp Gln His  Phe Pro Val Phe Met  Asn Glu Lys 
    1790                 1795                 1800             


Glu Asp  Ile Leu Trp Cys Thr  Glu Met Glu Arg Val  Phe Gly Phe 
    1805                 1810                 1815             


Pro Val  His Tyr Thr Asp Val  Ser Asn Met Ser Arg  Leu Ala Arg 
    1820                 1825                 1830             


Gln Arg  Leu Leu Gly Arg Ser  Trp Ser Val Pro Val  Ile Arg His 
    1835                 1840                 1845             


Leu Phe  Ala Pro Leu Lys Glu  Tyr Phe Ala Cys Val  Ser Ser Gly 
    1850                 1855                 1860             


Asn Ser  Asn Ala Asn Ser Arg  Gly Pro Ser Phe Ser  Ser Gly Leu 
    1865                 1870                 1875             


Val Pro  Leu Ser Leu Arg Gly  Ser His Met Gly Pro  Met Glu Ile 
    1880                 1885                 1890             


Tyr Lys  Thr Val Ser Ala Trp  Lys Arg Gln Pro Val  Arg Val Leu 
    1895                 1900                 1905             


Ser Leu  Phe Arg Asn Ile Asp  Lys Val Leu Lys Ser  Leu Gly Phe 
    1910                 1915                 1920             


Leu Glu  Ser Gly Ser Gly Ser  Gly Gly Gly Thr Leu  Lys Tyr Val 
    1925                 1930                 1935             


Glu Asp  Val Thr Asn Val Val  Arg Arg Asp Val Glu  Lys Trp Gly 
    1940                 1945                 1950             


Pro Phe  Asp Leu Val Tyr Gly  Ser Thr Gln Pro Leu  Gly Ser Ser 
    1955                 1960                 1965             


Cys Asp  Arg Cys Pro Gly Trp  Tyr Met Phe Gln Phe  His Arg Ile 
    1970                 1975                 1980             


Leu Gln  Tyr Ala Leu Pro Arg  Gln Glu Ser Gln Arg  Pro Phe Phe 
    1985                 1990                 1995             


Trp Ile  Phe Met Asp Asn Leu  Leu Leu Thr Glu Asp  Asp Gln Glu 
    2000                 2005                 2010             


Thr Thr  Thr Arg Phe Leu Gln  Thr Glu Ala Val Thr  Leu Gln Asp 
    2015                 2020                 2025             


Val Arg  Gly Arg Asp Tyr Gln  Asn Ala Met Arg Val  Trp Ser Asn 
    2030                 2035                 2040             


Ile Pro  Gly Leu Lys Ser Lys  His Ala Pro Leu Thr  Pro Lys Glu 
    2045                 2050                 2055             


Glu Glu  Tyr Leu Gln Ala Gln  Val Arg Ser Arg Ser  Lys Leu Asp 
    2060                 2065                 2070             


Ala Pro  Lys Val Asp Leu Leu  Val Lys Asn Cys Leu  Leu Pro Leu 
    2075                 2080                 2085             


Arg Glu  Tyr Phe Lys Tyr Phe  Ser Gln Asn Ser Leu  Pro Leu Ser 
    2090                 2095                 2100             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Ala Thr 
    2105                 2110                 2115             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    2120                 2125                 2130             


Gly Pro  Gly Ser Gly Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala 
    2135                 2140                 2145             


Gly Asp  Val Glu Glu Asn Pro  Gly Pro Ser Glu Leu  Ile Lys Glu 
    2150                 2155                 2160             


Asn Met  His Met Lys Leu Tyr  Met Glu Gly Thr Val  Asp Asn His 
    2165                 2170                 2175             


His Phe  Lys Cys Thr Ser Glu  Gly Glu Gly Lys Pro  Tyr Glu Gly 
    2180                 2185                 2190             


Thr Gln  Thr Met Arg Ile Lys  Val Val Glu Gly Gly  Pro Leu Pro 
    2195                 2200                 2205             


Phe Ala  Phe Asp Ile Leu Ala  Thr Ser Phe Leu Tyr  Gly Ser Lys 
    2210                 2215                 2220             


Thr Phe  Ile Asn His Thr Gln  Gly Ile Pro Asp Phe  Phe Lys Gln 
    2225                 2230                 2235             


Ser Phe  Pro Glu Gly Phe Thr  Trp Glu Arg Val Thr  Thr Tyr Glu 
    2240                 2245                 2250             


Asp Gly  Gly Val Leu Thr Ala  Thr Gln Asp Thr Ser  Leu Gln Asp 
    2255                 2260                 2265             


Gly Cys  Leu Ile Tyr Asn Val  Lys Ile Arg Gly Val  Asn Phe Thr 
    2270                 2275                 2280             


Ser Asn  Gly Pro Val Met Gln  Lys Lys Thr Leu Gly  Trp Glu Ala 
    2285                 2290                 2295             


Phe Thr  Glu Thr Leu Tyr Pro  Ala Asp Gly Gly Leu  Glu Gly Arg 
    2300                 2305                 2310             


Asn Asp  Met Ala Leu Lys Leu  Val Gly Gly Ser His  Leu Ile Ala 
    2315                 2320                 2325             


Asn Ile  Lys Thr Thr Tyr Arg  Ser Lys Lys Pro Ala  Lys Asn Leu 
    2330                 2335                 2340             


Lys Met  Pro Gly Val Tyr Tyr  Val Asp Tyr Arg Leu  Glu Arg Ile 
    2345                 2350                 2355             


Lys Glu  Ala Asn Asn Glu Thr  Tyr Val Glu Gln His  Glu Val Ala 
    2360                 2365                 2370             


Val Ala  Arg Tyr Cys Asp Leu  Pro Ser Lys Leu Gly  His Lys Leu 
    2375                 2380                 2385             


Asn 
    


<210>  11
<211>  2369
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Ser Gly Ser Glu Thr Pro Gly Thr Ser 
65                  70                  75                  80  


Glu Ser Ala Thr Pro Glu Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu 
                85                  90                  95      


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            100                 105                 110         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        115                 120                 125             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    130                 135                 140                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
145                 150                 155                 160 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                165                 170                 175     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            180                 185                 190         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        195                 200                 205             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    210                 215                 220                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
225                 230                 235                 240 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                245                 250                 255     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            260                 265                 270         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        275                 280                 285             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    290                 295                 300                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
305                 310                 315                 320 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                325                 330                 335     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            340                 345                 350         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        355                 360                 365             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    370                 375                 380                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
385                 390                 395                 400 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                405                 410                 415     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            420                 425                 430         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        435                 440                 445             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    450                 455                 460                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
465                 470                 475                 480 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                485                 490                 495     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            500                 505                 510         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        515                 520                 525             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    530                 535                 540                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
545                 550                 555                 560 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                565                 570                 575     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            580                 585                 590         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        595                 600                 605             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    610                 615                 620                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
625                 630                 635                 640 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                645                 650                 655     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            660                 665                 670         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        675                 680                 685             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    690                 695                 700                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
705                 710                 715                 720 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                725                 730                 735     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            740                 745                 750         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        755                 760                 765             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    770                 775                 780                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
785                 790                 795                 800 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                805                 810                 815     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            820                 825                 830         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        835                 840                 845             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    850                 855                 860                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
865                 870                 875                 880 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                885                 890                 895     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            900                 905                 910         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
        915                 920                 925             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    930                 935                 940                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
945                 950                 955                 960 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                965                 970                 975     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            980                 985                 990         


Gly Gly Leu Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
        995                 1000                 1005             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1010                 1015                 1020             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1025                 1030                 1035             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1040                 1045                 1050             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1055                 1060                 1065             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1070                 1075                 1080             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1085                 1090                 1095             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1100                 1105                 1110             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1115                 1120                 1125             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1130                 1135                 1140             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1145                 1150                 1155             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1160                 1165                 1170             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1175                 1180                 1185             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1190                 1195                 1200             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1205                 1210                 1215             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1220                 1225                 1230             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1235                 1240                 1245             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1250                 1255                 1260             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1265                 1270                 1275             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1280                 1285                 1290             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1295                 1300                 1305             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1325                 1330                 1335             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1340                 1345                 1350             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1355                 1360                 1365             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1370                 1375                 1380             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1385                 1390                 1395             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1400                 1405                 1410             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1415                 1420                 1425             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1430                 1435                 1440             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Arg Ala 
    1445                 1450                 1455             


Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Ser Gly  Ser Pro Lys 
    1460                 1465                 1470             


Lys Lys  Arg Lys Val Ser Pro  Gly Gly Gly Pro Ser  Ser Gly Ala 
    1475                 1480                 1485             


Pro Pro  Pro Ser Gly Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr 
    1490                 1495                 1500             


Glu Glu  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 
    1505                 1510                 1515             


Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Pro Ala 
    1520                 1525                 1530             


Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser 
    1535                 1540                 1545             


Glu Gly  Ser Ala Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Asn His 
    1550                 1555                 1560             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1565                 1570                 1575             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1580                 1585                 1590             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1595                 1600                 1605             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1610                 1615                 1620             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1625                 1630                 1635             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1640                 1645                 1650             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1655                 1660                 1665             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1670                 1675                 1680             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1685                 1690                 1695             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1700                 1705                 1710             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1715                 1720                 1725             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1730                 1735                 1740             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1745                 1750                 1755             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1760                 1765                 1770             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1775                 1780                 1785             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1790                 1795                 1800             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1805                 1810                 1815             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1820                 1825                 1830             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1835                 1840                 1845             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1850                 1855                 1860             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1865                 1870                 1875             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1880                 1885                 1890             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1895                 1900                 1905             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1910                 1915                 1920             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1925                 1930                 1935             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1940                 1945                 1950             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1955                 1960                 1965             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1970                 1975                 1980             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1985                 1990                 1995             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    2000                 2005                 2010             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    2015                 2020                 2025             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    2030                 2035                 2040             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    2045                 2050                 2055             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    2060                 2065                 2070             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2075                 2080                 2085             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2090                 2095                 2100             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2105                 2110                 2115             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2120                 2125                 2130             


Asn Pro  Gly Pro Ser Glu Leu  Ile Lys Glu Asn Met  His Met Lys 
    2135                 2140                 2145             


Leu Tyr  Met Glu Gly Thr Val  Asp Asn His His Phe  Lys Cys Thr 
    2150                 2155                 2160             


Ser Glu  Gly Glu Gly Lys Pro  Tyr Glu Gly Thr Gln  Thr Met Arg 
    2165                 2170                 2175             


Ile Lys  Val Val Glu Gly Gly  Pro Leu Pro Phe Ala  Phe Asp Ile 
    2180                 2185                 2190             


Leu Ala  Thr Ser Phe Leu Tyr  Gly Ser Lys Thr Phe  Ile Asn His 
    2195                 2200                 2205             


Thr Gln  Gly Ile Pro Asp Phe  Phe Lys Gln Ser Phe  Pro Glu Gly 
    2210                 2215                 2220             


Phe Thr  Trp Glu Arg Val Thr  Thr Tyr Glu Asp Gly  Gly Val Leu 
    2225                 2230                 2235             


Thr Ala  Thr Gln Asp Thr Ser  Leu Gln Asp Gly Cys  Leu Ile Tyr 
    2240                 2245                 2250             


Asn Val  Lys Ile Arg Gly Val  Asn Phe Thr Ser Asn  Gly Pro Val 
    2255                 2260                 2265             


Met Gln  Lys Lys Thr Leu Gly  Trp Glu Ala Phe Thr  Glu Thr Leu 
    2270                 2275                 2280             


Tyr Pro  Ala Asp Gly Gly Leu  Glu Gly Arg Asn Asp  Met Ala Leu 
    2285                 2290                 2295             


Lys Leu  Val Gly Gly Ser His  Leu Ile Ala Asn Ile  Lys Thr Thr 
    2300                 2305                 2310             


Tyr Arg  Ser Lys Lys Pro Ala  Lys Asn Leu Lys Met  Pro Gly Val 
    2315                 2320                 2325             


Tyr Tyr  Val Asp Tyr Arg Leu  Glu Arg Ile Lys Glu  Ala Asn Asn 
    2330                 2335                 2340             


Glu Thr  Tyr Val Glu Gln His  Glu Val Ala Val Ala  Arg Tyr Cys 
    2345                 2350                 2355             


Asp Leu  Pro Ser Lys Leu Gly  His Lys Leu Asn 
    2360                 2365                 


<210>  12
<211>  2391
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Ser Gly Ser Glu Thr Pro Gly Thr Ser 
65                  70                  75                  80  


Glu Ser Ala Thr Pro Glu Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu 
                85                  90                  95      


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            100                 105                 110         


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        115                 120                 125             


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    130                 135                 140                 


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
145                 150                 155                 160 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                165                 170                 175     


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            180                 185                 190         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        195                 200                 205             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    210                 215                 220                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
225                 230                 235                 240 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                245                 250                 255     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            260                 265                 270         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        275                 280                 285             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    290                 295                 300                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
305                 310                 315                 320 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                325                 330                 335     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            340                 345                 350         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        355                 360                 365             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    370                 375                 380                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
385                 390                 395                 400 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                405                 410                 415     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            420                 425                 430         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        435                 440                 445             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    450                 455                 460                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
465                 470                 475                 480 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                485                 490                 495     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            500                 505                 510         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        515                 520                 525             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    530                 535                 540                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
545                 550                 555                 560 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                565                 570                 575     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            580                 585                 590         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        595                 600                 605             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    610                 615                 620                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
625                 630                 635                 640 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                645                 650                 655     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            660                 665                 670         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        675                 680                 685             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    690                 695                 700                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
705                 710                 715                 720 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                725                 730                 735     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            740                 745                 750         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        755                 760                 765             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    770                 775                 780                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
785                 790                 795                 800 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                805                 810                 815     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            820                 825                 830         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        835                 840                 845             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    850                 855                 860                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
865                 870                 875                 880 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                885                 890                 895     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            900                 905                 910         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
        915                 920                 925             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    930                 935                 940                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
945                 950                 955                 960 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                965                 970                 975     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            980                 985                 990         


Gly Gly Leu Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
        995                 1000                 1005             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1010                 1015                 1020             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1025                 1030                 1035             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1040                 1045                 1050             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1055                 1060                 1065             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1070                 1075                 1080             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1085                 1090                 1095             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1100                 1105                 1110             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1115                 1120                 1125             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1130                 1135                 1140             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1145                 1150                 1155             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1160                 1165                 1170             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1175                 1180                 1185             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1190                 1195                 1200             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1205                 1210                 1215             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1220                 1225                 1230             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1235                 1240                 1245             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1250                 1255                 1260             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1265                 1270                 1275             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1280                 1285                 1290             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1295                 1300                 1305             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1310                 1315                 1320             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1325                 1330                 1335             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1340                 1345                 1350             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1355                 1360                 1365             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1370                 1375                 1380             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1385                 1390                 1395             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1400                 1405                 1410             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1415                 1420                 1425             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1430                 1435                 1440             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Arg Ala 
    1445                 1450                 1455             


Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Ser Gly  Ser Pro Lys 
    1460                 1465                 1470             


Lys Lys  Arg Lys Val Ser Pro  Gly Gly Gly Pro Ser  Ser Gly Ala 
    1475                 1480                 1485             


Pro Pro  Pro Ser Gly Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr 
    1490                 1495                 1500             


Glu Glu  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 
    1505                 1510                 1515             


Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Pro Ala 
    1520                 1525                 1530             


Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser 
    1535                 1540                 1545             


Glu Gly  Ser Ala Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Asn His 
    1550                 1555                 1560             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1565                 1570                 1575             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1580                 1585                 1590             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1595                 1600                 1605             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1610                 1615                 1620             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1625                 1630                 1635             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1640                 1645                 1650             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1655                 1660                 1665             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1670                 1675                 1680             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1685                 1690                 1695             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1700                 1705                 1710             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1715                 1720                 1725             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1730                 1735                 1740             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1745                 1750                 1755             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1760                 1765                 1770             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1775                 1780                 1785             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1790                 1795                 1800             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1805                 1810                 1815             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1820                 1825                 1830             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1835                 1840                 1845             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1850                 1855                 1860             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1865                 1870                 1875             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1880                 1885                 1890             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1895                 1900                 1905             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1910                 1915                 1920             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1925                 1930                 1935             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1940                 1945                 1950             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1955                 1960                 1965             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1970                 1975                 1980             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1985                 1990                 1995             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    2000                 2005                 2010             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    2015                 2020                 2025             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    2030                 2035                 2040             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    2045                 2050                 2055             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    2060                 2065                 2070             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2075                 2080                 2085             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2090                 2095                 2100             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2105                 2110                 2115             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2120                 2125                 2130             


Asn Pro  Gly Pro Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    2135                 2140                 2145             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Ser  Glu Leu Ile 
    2150                 2155                 2160             


Lys Glu  Asn Met His Met Lys  Leu Tyr Met Glu Gly  Thr Val Asp 
    2165                 2170                 2175             


Asn His  His Phe Lys Cys Thr  Ser Glu Gly Glu Gly  Lys Pro Tyr 
    2180                 2185                 2190             


Glu Gly  Thr Gln Thr Met Arg  Ile Lys Val Val Glu  Gly Gly Pro 
    2195                 2200                 2205             


Leu Pro  Phe Ala Phe Asp Ile  Leu Ala Thr Ser Phe  Leu Tyr Gly 
    2210                 2215                 2220             


Ser Lys  Thr Phe Ile Asn His  Thr Gln Gly Ile Pro  Asp Phe Phe 
    2225                 2230                 2235             


Lys Gln  Ser Phe Pro Glu Gly  Phe Thr Trp Glu Arg  Val Thr Thr 
    2240                 2245                 2250             


Tyr Glu  Asp Gly Gly Val Leu  Thr Ala Thr Gln Asp  Thr Ser Leu 
    2255                 2260                 2265             


Gln Asp  Gly Cys Leu Ile Tyr  Asn Val Lys Ile Arg  Gly Val Asn 
    2270                 2275                 2280             


Phe Thr  Ser Asn Gly Pro Val  Met Gln Lys Lys Thr  Leu Gly Trp 
    2285                 2290                 2295             


Glu Ala  Phe Thr Glu Thr Leu  Tyr Pro Ala Asp Gly  Gly Leu Glu 
    2300                 2305                 2310             


Gly Arg  Asn Asp Met Ala Leu  Lys Leu Val Gly Gly  Ser His Leu 
    2315                 2320                 2325             


Ile Ala  Asn Ile Lys Thr Thr  Tyr Arg Ser Lys Lys  Pro Ala Lys 
    2330                 2335                 2340             


Asn Leu  Lys Met Pro Gly Val  Tyr Tyr Val Asp Tyr  Arg Leu Glu 
    2345                 2350                 2355             


Arg Ile  Lys Glu Ala Asn Asn  Glu Thr Tyr Val Glu  Gln His Glu 
    2360                 2365                 2370             


Val Ala  Val Ala Arg Tyr Cys  Asp Leu Pro Ser Lys  Leu Gly His 
    2375                 2380                 2385             


Lys Leu  Asn 
    2390     


<210>  13
<211>  2369
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Pro Ser Ser Gly Ala Pro Pro 
65                  70                  75                  80  


Pro Ser Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


Thr Ser Thr Glu Pro Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu 
145                 150                 155                 160 


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
                165                 170                 175     


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
            180                 185                 190         


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
        195                 200                 205             


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
    210                 215                 220                 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
225                 230                 235                 240 


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
                245                 250                 255     


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
            260                 265                 270         


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
        275                 280                 285             


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
    290                 295                 300                 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
305                 310                 315                 320 


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
                325                 330                 335     


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
            340                 345                 350         


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
        355                 360                 365             


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
    370                 375                 380                 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
385                 390                 395                 400 


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
                405                 410                 415     


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
            420                 425                 430         


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
        435                 440                 445             


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
    450                 455                 460                 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
465                 470                 475                 480 


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
                485                 490                 495     


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
            500                 505                 510         


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
        515                 520                 525             


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
    530                 535                 540                 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
545                 550                 555                 560 


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
                565                 570                 575     


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
            580                 585                 590         


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
        595                 600                 605             


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
    610                 615                 620                 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
625                 630                 635                 640 


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
                645                 650                 655     


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
            660                 665                 670         


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
        675                 680                 685             


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
    690                 695                 700                 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
705                 710                 715                 720 


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
                725                 730                 735     


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
            740                 745                 750         


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
        755                 760                 765             


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
    770                 775                 780                 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
785                 790                 795                 800 


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
                805                 810                 815     


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
            820                 825                 830         


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
        835                 840                 845             


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
    850                 855                 860                 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
865                 870                 875                 880 


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
                885                 890                 895     


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
            900                 905                 910         


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
        915                 920                 925             


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
    930                 935                 940                 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
945                 950                 955                 960 


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
                965                 970                 975     


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
            980                 985                 990         


Val Pro Gln Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
        995                 1000                 1005             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1010                 1015                 1020             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1025                 1030                 1035             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1040                 1045                 1050             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1055                 1060                 1065             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1070                 1075                 1080             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1085                 1090                 1095             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1100                 1105                 1110             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1115                 1120                 1125             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1130                 1135                 1140             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1145                 1150                 1155             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1160                 1165                 1170             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1175                 1180                 1185             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1190                 1195                 1200             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1205                 1210                 1215             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1220                 1225                 1230             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1235                 1240                 1245             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1250                 1255                 1260             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1265                 1270                 1275             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1280                 1285                 1290             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1295                 1300                 1305             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1310                 1315                 1320             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1325                 1330                 1335             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1340                 1345                 1350             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1355                 1360                 1365             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1370                 1375                 1380             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1385                 1390                 1395             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1400                 1405                 1410             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1415                 1420                 1425             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1430                 1435                 1440             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1460                 1465                 1470             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1475                 1480                 1485             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1490                 1495                 1500             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1505                 1510                 1515             


Asp Ser  Arg Ala Asp Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Ser 
    1520                 1525                 1530             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Pro Gly  Ser Gly Ser 
    1535                 1540                 1545             


Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Asn His 
    1550                 1555                 1560             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1565                 1570                 1575             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1580                 1585                 1590             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1595                 1600                 1605             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1610                 1615                 1620             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1625                 1630                 1635             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1640                 1645                 1650             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1655                 1660                 1665             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1670                 1675                 1680             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1685                 1690                 1695             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1700                 1705                 1710             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1715                 1720                 1725             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1730                 1735                 1740             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1745                 1750                 1755             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1760                 1765                 1770             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1775                 1780                 1785             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1790                 1795                 1800             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1805                 1810                 1815             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1820                 1825                 1830             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1835                 1840                 1845             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1850                 1855                 1860             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1865                 1870                 1875             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1880                 1885                 1890             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1895                 1900                 1905             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1910                 1915                 1920             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1925                 1930                 1935             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1940                 1945                 1950             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1955                 1960                 1965             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1970                 1975                 1980             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1985                 1990                 1995             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    2000                 2005                 2010             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    2015                 2020                 2025             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    2030                 2035                 2040             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    2045                 2050                 2055             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    2060                 2065                 2070             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2075                 2080                 2085             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2090                 2095                 2100             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2105                 2110                 2115             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2120                 2125                 2130             


Asn Pro  Gly Pro Ser Glu Leu  Ile Lys Glu Asn Met  His Met Lys 
    2135                 2140                 2145             


Leu Tyr  Met Glu Gly Thr Val  Asp Asn His His Phe  Lys Cys Thr 
    2150                 2155                 2160             


Ser Glu  Gly Glu Gly Lys Pro  Tyr Glu Gly Thr Gln  Thr Met Arg 
    2165                 2170                 2175             


Ile Lys  Val Val Glu Gly Gly  Pro Leu Pro Phe Ala  Phe Asp Ile 
    2180                 2185                 2190             


Leu Ala  Thr Ser Phe Leu Tyr  Gly Ser Lys Thr Phe  Ile Asn His 
    2195                 2200                 2205             


Thr Gln  Gly Ile Pro Asp Phe  Phe Lys Gln Ser Phe  Pro Glu Gly 
    2210                 2215                 2220             


Phe Thr  Trp Glu Arg Val Thr  Thr Tyr Glu Asp Gly  Gly Val Leu 
    2225                 2230                 2235             


Thr Ala  Thr Gln Asp Thr Ser  Leu Gln Asp Gly Cys  Leu Ile Tyr 
    2240                 2245                 2250             


Asn Val  Lys Ile Arg Gly Val  Asn Phe Thr Ser Asn  Gly Pro Val 
    2255                 2260                 2265             


Met Gln  Lys Lys Thr Leu Gly  Trp Glu Ala Phe Thr  Glu Thr Leu 
    2270                 2275                 2280             


Tyr Pro  Ala Asp Gly Gly Leu  Glu Gly Arg Asn Asp  Met Ala Leu 
    2285                 2290                 2295             


Lys Leu  Val Gly Gly Ser His  Leu Ile Ala Asn Ile  Lys Thr Thr 
    2300                 2305                 2310             


Tyr Arg  Ser Lys Lys Pro Ala  Lys Asn Leu Lys Met  Pro Gly Val 
    2315                 2320                 2325             


Tyr Tyr  Val Asp Tyr Arg Leu  Glu Arg Ile Lys Glu  Ala Asn Asn 
    2330                 2335                 2340             


Glu Thr  Tyr Val Glu Gln His  Glu Val Ala Val Ala  Arg Tyr Cys 
    2345                 2350                 2355             


Asp Leu  Pro Ser Lys Leu Gly  His Lys Leu Asn 
    2360                 2365                 


<210>  14
<211>  2391
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro Gly Gly Pro Ser Ser Gly Ala Pro Pro 
65                  70                  75                  80  


Pro Ser Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


Thr Ser Thr Glu Pro Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu 
145                 150                 155                 160 


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
                165                 170                 175     


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
            180                 185                 190         


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
        195                 200                 205             


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
    210                 215                 220                 


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
225                 230                 235                 240 


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
                245                 250                 255     


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
            260                 265                 270         


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
        275                 280                 285             


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
    290                 295                 300                 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
305                 310                 315                 320 


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
                325                 330                 335     


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
            340                 345                 350         


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
        355                 360                 365             


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
    370                 375                 380                 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
385                 390                 395                 400 


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
                405                 410                 415     


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
            420                 425                 430         


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
        435                 440                 445             


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
    450                 455                 460                 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
465                 470                 475                 480 


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
                485                 490                 495     


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
            500                 505                 510         


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
        515                 520                 525             


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
    530                 535                 540                 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
545                 550                 555                 560 


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
                565                 570                 575     


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
            580                 585                 590         


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
        595                 600                 605             


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
    610                 615                 620                 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
625                 630                 635                 640 


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
                645                 650                 655     


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
            660                 665                 670         


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
        675                 680                 685             


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
    690                 695                 700                 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
705                 710                 715                 720 


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
                725                 730                 735     


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
            740                 745                 750         


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
        755                 760                 765             


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
    770                 775                 780                 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
785                 790                 795                 800 


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
                805                 810                 815     


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
            820                 825                 830         


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
        835                 840                 845             


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
    850                 855                 860                 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
865                 870                 875                 880 


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
                885                 890                 895     


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
            900                 905                 910         


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
        915                 920                 925             


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
    930                 935                 940                 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
945                 950                 955                 960 


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
                965                 970                 975     


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
            980                 985                 990         


Val Pro Gln Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
        995                 1000                 1005             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1010                 1015                 1020             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1025                 1030                 1035             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1040                 1045                 1050             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1055                 1060                 1065             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1070                 1075                 1080             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1085                 1090                 1095             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1100                 1105                 1110             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1115                 1120                 1125             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1130                 1135                 1140             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1145                 1150                 1155             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1160                 1165                 1170             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1175                 1180                 1185             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1190                 1195                 1200             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1205                 1210                 1215             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1220                 1225                 1230             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1235                 1240                 1245             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1250                 1255                 1260             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1265                 1270                 1275             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1280                 1285                 1290             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1295                 1300                 1305             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1310                 1315                 1320             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1325                 1330                 1335             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1340                 1345                 1350             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1355                 1360                 1365             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1370                 1375                 1380             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1385                 1390                 1395             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1400                 1405                 1410             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1415                 1420                 1425             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1430                 1435                 1440             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1460                 1465                 1470             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1475                 1480                 1485             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1490                 1495                 1500             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1505                 1510                 1515             


Asp Ser  Arg Ala Asp Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Ser 
    1520                 1525                 1530             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Pro Gly  Ser Gly Ser 
    1535                 1540                 1545             


Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Asn His 
    1550                 1555                 1560             


Asp Gln  Glu Phe Asp Pro Pro  Lys Val Tyr Pro Pro  Val Pro Ala 
    1565                 1570                 1575             


Glu Lys  Arg Lys Pro Ile Arg  Val Leu Ser Leu Phe  Asp Gly Ile 
    1580                 1585                 1590             


Ala Thr  Gly Leu Leu Val Leu  Lys Asp Leu Gly Ile  Gln Val Asp 
    1595                 1600                 1605             


Arg Tyr  Ile Ala Ser Glu Val  Cys Glu Asp Ser Ile  Thr Val Gly 
    1610                 1615                 1620             


Met Val  Arg His Gln Gly Lys  Ile Met Tyr Val Gly  Asp Val Arg 
    1625                 1630                 1635             


Ser Val  Thr Gln Lys His Ile  Gln Glu Trp Gly Pro  Phe Asp Leu 
    1640                 1645                 1650             


Val Ile  Gly Gly Ser Pro Cys  Asn Asp Leu Ser Ile  Val Asn Pro 
    1655                 1660                 1665             


Ala Arg  Lys Gly Leu Tyr Glu  Gly Thr Gly Arg Leu  Phe Phe Glu 
    1670                 1675                 1680             


Phe Tyr  Arg Leu Leu His Asp  Ala Arg Pro Lys Glu  Gly Asp Asp 
    1685                 1690                 1695             


Arg Pro  Phe Phe Trp Leu Phe  Glu Asn Val Val Ala  Met Gly Val 
    1700                 1705                 1710             


Ser Asp  Lys Arg Asp Ile Ser  Arg Phe Leu Glu Ser  Asn Pro Val 
    1715                 1720                 1725             


Met Ile  Asp Ala Lys Glu Val  Ser Ala Ala His Arg  Ala Arg Tyr 
    1730                 1735                 1740             


Phe Trp  Gly Asn Leu Pro Gly  Met Asn Arg Pro Leu  Ala Ser Thr 
    1745                 1750                 1755             


Val Asn  Asp Lys Leu Glu Leu  Gln Glu Cys Leu Glu  His Gly Arg 
    1760                 1765                 1770             


Ile Ala  Lys Phe Ser Lys Val  Arg Thr Ile Thr Thr  Arg Ser Asn 
    1775                 1780                 1785             


Ser Ile  Lys Gln Gly Lys Asp  Gln His Phe Pro Val  Phe Met Asn 
    1790                 1795                 1800             


Glu Lys  Glu Asp Ile Leu Trp  Cys Thr Glu Met Glu  Arg Val Phe 
    1805                 1810                 1815             


Gly Phe  Pro Val His Tyr Thr  Asp Val Ser Asn Met  Ser Arg Leu 
    1820                 1825                 1830             


Ala Arg  Gln Arg Leu Leu Gly  Arg Ser Trp Ser Val  Pro Val Ile 
    1835                 1840                 1845             


Arg His  Leu Phe Ala Pro Leu  Lys Glu Tyr Phe Ala  Cys Val Ser 
    1850                 1855                 1860             


Ser Gly  Asn Ser Asn Ala Asn  Ser Arg Gly Pro Ser  Phe Ser Ser 
    1865                 1870                 1875             


Gly Leu  Val Pro Leu Ser Leu  Arg Gly Ser His Met  Gly Pro Met 
    1880                 1885                 1890             


Glu Ile  Tyr Lys Thr Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg 
    1895                 1900                 1905             


Val Leu  Ser Leu Phe Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu 
    1910                 1915                 1920             


Gly Phe  Leu Glu Ser Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys 
    1925                 1930                 1935             


Tyr Val  Glu Asp Val Thr Asn  Val Val Arg Arg Asp  Val Glu Lys 
    1940                 1945                 1950             


Trp Gly  Pro Phe Asp Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly 
    1955                 1960                 1965             


Ser Ser  Cys Asp Arg Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His 
    1970                 1975                 1980             


Arg Ile  Leu Gln Tyr Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro 
    1985                 1990                 1995             


Phe Phe  Trp Ile Phe Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp 
    2000                 2005                 2010             


Gln Glu  Thr Thr Thr Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu 
    2015                 2020                 2025             


Gln Asp  Val Arg Gly Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp 
    2030                 2035                 2040             


Ser Asn  Ile Pro Gly Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro 
    2045                 2050                 2055             


Lys Glu  Glu Glu Tyr Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys 
    2060                 2065                 2070             


Leu Asp  Ala Pro Lys Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu 
    2075                 2080                 2085             


Pro Leu  Arg Glu Tyr Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro 
    2090                 2095                 2100             


Leu Ser  Arg Ala Asp Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    2105                 2110                 2115             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2120                 2125                 2130             


Asn Pro  Gly Pro Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    2135                 2140                 2145             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Ser  Glu Leu Ile 
    2150                 2155                 2160             


Lys Glu  Asn Met His Met Lys  Leu Tyr Met Glu Gly  Thr Val Asp 
    2165                 2170                 2175             


Asn His  His Phe Lys Cys Thr  Ser Glu Gly Glu Gly  Lys Pro Tyr 
    2180                 2185                 2190             


Glu Gly  Thr Gln Thr Met Arg  Ile Lys Val Val Glu  Gly Gly Pro 
    2195                 2200                 2205             


Leu Pro  Phe Ala Phe Asp Ile  Leu Ala Thr Ser Phe  Leu Tyr Gly 
    2210                 2215                 2220             


Ser Lys  Thr Phe Ile Asn His  Thr Gln Gly Ile Pro  Asp Phe Phe 
    2225                 2230                 2235             


Lys Gln  Ser Phe Pro Glu Gly  Phe Thr Trp Glu Arg  Val Thr Thr 
    2240                 2245                 2250             


Tyr Glu  Asp Gly Gly Val Leu  Thr Ala Thr Gln Asp  Thr Ser Leu 
    2255                 2260                 2265             


Gln Asp  Gly Cys Leu Ile Tyr  Asn Val Lys Ile Arg  Gly Val Asn 
    2270                 2275                 2280             


Phe Thr  Ser Asn Gly Pro Val  Met Gln Lys Lys Thr  Leu Gly Trp 
    2285                 2290                 2295             


Glu Ala  Phe Thr Glu Thr Leu  Tyr Pro Ala Asp Gly  Gly Leu Glu 
    2300                 2305                 2310             


Gly Arg  Asn Asp Met Ala Leu  Lys Leu Val Gly Gly  Ser His Leu 
    2315                 2320                 2325             


Ile Ala  Asn Ile Lys Thr Thr  Tyr Arg Ser Lys Lys  Pro Ala Lys 
    2330                 2335                 2340             


Asn Leu  Lys Met Pro Gly Val  Tyr Tyr Val Asp Tyr  Arg Leu Glu 
    2345                 2350                 2355             


Arg Ile  Lys Glu Ala Asn Asn  Glu Thr Tyr Val Glu  Gln His Glu 
    2360                 2365                 2370             


Val Ala  Val Ala Arg Tyr Cys  Asp Leu Pro Ser Lys  Leu Gly His 
    2375                 2380                 2385             


Lys Leu  Asn 
    2390     


<210>  15
<211>  2345
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro 
1               5                   10                  15      


Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile 
            20                  25                  30          


Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg 
        35                  40                  45              


Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val 
    50                  55                  60                  


Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr 
65                  70                  75                  80  


Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly 
                85                  90                  95      


Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu 
            100                 105                 110         


Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His 
        115                 120                 125             


Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe 
    130                 135                 140                 


Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala 
                165                 170                 175     


Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg 
            180                 185                 190         


Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu 
        195                 200                 205             


Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr 
    210                 215                 220                 


Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe 
225                 230                 235                 240 


Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val 
                245                 250                 255     


Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu 
            260                 265                 270         


Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg 
        275                 280                 285             


His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val Ser Ser Gly 
    290                 295                 300                 


Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser Gly Leu Val 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Gly Ser His Met Gly Pro Met Glu Ile Tyr Lys 
                325                 330                 335     


Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe 
            340                 345                 350         


Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly 
        355                 360                 365             


Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn 
    370                 375                 380                 


Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr 
385                 390                 395                 400 


Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp 
                405                 410                 415     


Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln 
            420                 425                 430         


Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu 
        435                 440                 445             


Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala 
    450                 455                 460                 


Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg 
465                 470                 475                 480 


Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr 
                485                 490                 495     


Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys 
            500                 505                 510         


Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro 
        515                 520                 525             


Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu Gly 
    530                 535                 540                 


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Pro Ala Gly 
545                 550                 555                 560 


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
                565                 570                 575     


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
            580                 585                 590         


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 
        595                 600                 605             


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Met 
    610                 615                 620                 


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
625                 630                 635                 640 


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
                645                 650                 655     


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
            660                 665                 670         


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
        675                 680                 685             


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
    690                 695                 700                 


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
705                 710                 715                 720 


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
                725                 730                 735     


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
            740                 745                 750         


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
        755                 760                 765             


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
    770                 775                 780                 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
785                 790                 795                 800 


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
                805                 810                 815     


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
            820                 825                 830         


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
        835                 840                 845             


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
    850                 855                 860                 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
865                 870                 875                 880 


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
                885                 890                 895     


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
            900                 905                 910         


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
        915                 920                 925             


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
    930                 935                 940                 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
945                 950                 955                 960 


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
                965                 970                 975     


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
            980                 985                 990         


Glu Glu Phe Tyr Lys Phe Ile Lys  Pro Ile Leu Glu Lys  Met Asp Gly 
        995                 1000                 1005             


Thr Glu  Glu Leu Leu Val Lys  Leu Asn Arg Glu Asp  Leu Leu Arg 
    1010                 1015                 1020             


Lys Gln  Arg Thr Phe Asp Asn  Gly Ser Ile Pro His  Gln Ile His 
    1025                 1030                 1035             


Leu Gly  Glu Leu His Ala Ile  Leu Arg Arg Gln Glu  Asp Phe Tyr 
    1040                 1045                 1050             


Pro Phe  Leu Lys Asp Asn Arg  Glu Lys Ile Glu Lys  Ile Leu Thr 
    1055                 1060                 1065             


Phe Arg  Ile Pro Tyr Tyr Val  Gly Pro Leu Ala Arg  Gly Asn Ser 
    1070                 1075                 1080             


Arg Phe  Ala Trp Met Thr Arg  Lys Ser Glu Glu Thr  Ile Thr Pro 
    1085                 1090                 1095             


Trp Asn  Phe Glu Glu Val Val  Asp Lys Gly Ala Ser  Ala Gln Ser 
    1100                 1105                 1110             


Phe Ile  Glu Arg Met Thr Asn  Phe Asp Lys Asn Leu  Pro Asn Glu 
    1115                 1120                 1125             


Lys Val  Leu Pro Lys His Ser  Leu Leu Tyr Glu Tyr  Phe Thr Val 
    1130                 1135                 1140             


Tyr Asn  Glu Leu Thr Lys Val  Lys Tyr Val Thr Glu  Gly Met Arg 
    1145                 1150                 1155             


Lys Pro  Ala Phe Leu Ser Gly  Glu Gln Lys Lys Ala  Ile Val Asp 
    1160                 1165                 1170             


Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr Val Lys  Gln Leu Lys 
    1175                 1180                 1185             


Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe Asp Ser  Val Glu Ile 
    1190                 1195                 1200             


Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser Leu Gly  Thr Tyr His 
    1205                 1210                 1215             


Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
    1220                 1225                 1230             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1235                 1240                 1245             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1250                 1255                 1260             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1265                 1270                 1275             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1280                 1285                 1290             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1295                 1300                 1305             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1310                 1315                 1320             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1325                 1330                 1335             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1340                 1345                 1350             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1355                 1360                 1365             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1370                 1375                 1380             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1385                 1390                 1395             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1400                 1405                 1410             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1415                 1420                 1425             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1430                 1435                 1440             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1445                 1450                 1455             


Tyr Asp  Val Asp Ala Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1460                 1465                 1470             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1475                 1480                 1485             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1490                 1495                 1500             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1505                 1510                 1515             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1520                 1525                 1530             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1535                 1540                 1545             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1550                 1555                 1560             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1565                 1570                 1575             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1580                 1585                 1590             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1595                 1600                 1605             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1610                 1615                 1620             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1625                 1630                 1635             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1640                 1645                 1650             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1655                 1660                 1665             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1670                 1675                 1680             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1685                 1690                 1695             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1700                 1705                 1710             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1715                 1720                 1725             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1730                 1735                 1740             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1745                 1750                 1755             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1760                 1765                 1770             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1775                 1780                 1785             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1790                 1795                 1800             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1805                 1810                 1815             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1820                 1825                 1830             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1835                 1840                 1845             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1850                 1855                 1860             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1865                 1870                 1875             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1880                 1885                 1890             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1895                 1900                 1905             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1910                 1915                 1920             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1925                 1930                 1935             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1940                 1945                 1950             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1955                 1960                 1965             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1970                 1975                 1980             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ala Tyr Pro Tyr  Asp Val Pro 
    1985                 1990                 1995             


Asp Tyr  Ala Ser Leu Gly Ser  Gly Ser Pro Lys Lys  Lys Arg Lys 
    2000                 2005                 2010             


Val Glu  Asp Pro Lys Lys Lys  Arg Lys Val Asp Gly  Ile Gly Ser 
    2015                 2020                 2025             


Gly Ser  Asn Gly Ser Ser Gly  Ser Ser Glu Leu Ile  Lys Glu Asn 
    2030                 2035                 2040             


Met His  Met Lys Leu Tyr Met  Glu Gly Thr Val Asp  Asn His His 
    2045                 2050                 2055             


Phe Lys  Cys Thr Ser Glu Gly  Glu Gly Lys Pro Tyr  Glu Gly Thr 
    2060                 2065                 2070             


Gln Thr  Met Arg Ile Lys Val  Val Glu Gly Gly Pro  Leu Pro Phe 
    2075                 2080                 2085             


Ala Phe  Asp Ile Leu Ala Thr  Ser Phe Leu Tyr Gly  Ser Lys Thr 
    2090                 2095                 2100             


Phe Ile  Asn His Thr Gln Gly  Ile Pro Asp Phe Phe  Lys Gln Ser 
    2105                 2110                 2115             


Phe Pro  Glu Gly Phe Thr Trp  Glu Arg Val Thr Thr  Tyr Glu Asp 
    2120                 2125                 2130             


Gly Gly  Val Leu Thr Ala Thr  Gln Asp Thr Ser Leu  Gln Asp Gly 
    2135                 2140                 2145             


Cys Leu  Ile Tyr Asn Val Lys  Ile Arg Gly Val Asn  Phe Thr Ser 
    2150                 2155                 2160             


Asn Gly  Pro Val Met Gln Lys  Lys Thr Leu Gly Trp  Glu Ala Phe 
    2165                 2170                 2175             


Thr Glu  Thr Leu Tyr Pro Ala  Asp Gly Gly Leu Glu  Gly Arg Asn 
    2180                 2185                 2190             


Asp Met  Ala Leu Lys Leu Val  Gly Gly Ser His Leu  Ile Ala Asn 
    2195                 2200                 2205             


Ile Lys  Thr Thr Tyr Arg Ser  Lys Lys Pro Ala Lys  Asn Leu Lys 
    2210                 2215                 2220             


Met Pro  Gly Val Tyr Tyr Val  Asp Tyr Arg Leu Glu  Arg Ile Lys 
    2225                 2230                 2235             


Glu Ala  Asn Asn Glu Thr Tyr  Val Glu Gln His Glu  Val Ala Val 
    2240                 2245                 2250             


Ala Arg  Tyr Cys Asp Leu Pro  Ser Lys Leu Gly His  Lys Leu Asn 
    2255                 2260                 2265             


Gly Gly  Gly Gly Gly Met Asp  Ala Lys Ser Leu Thr  Ala Trp Ser 
    2270                 2275                 2280             


Arg Thr  Leu Val Thr Phe Lys  Asp Val Phe Val Asp  Phe Thr Arg 
    2285                 2290                 2295             


Glu Glu  Trp Lys Leu Leu Asp  Thr Ala Gln Gln Ile  Val Tyr Arg 
    2300                 2305                 2310             


Asn Val  Met Leu Glu Asn Tyr  Lys Asn Leu Val Ser  Leu Gly Tyr 
    2315                 2320                 2325             


Gln Leu  Thr Lys Pro Asp Val  Ile Leu Arg Leu Glu  Lys Gly Glu 
    2330                 2335                 2340             


Glu Pro  
    2345 


<210>  16
<211>  71
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys 
1               5                   10                  15      


Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr 
            20                  25                  30          


Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn 
        35                  40                  45              


Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg 
    50                  55                  60                  


Leu Glu Lys Gly Glu Glu Pro 
65                  70      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Gly Gly Ser Gly Gly Gly Ser 
1               5           


<210>  18
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Ser Gly Ser 
1           


<210>  19
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Glu Ala Ser Gly Ser Gly Arg Ala Ser Pro Gly Ile Pro Gly Ser Thr 
1               5                   10                  15      


Arg 
    


<210>  20
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Ser Arg Ala Asp 
1               


<210>  21
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Ser Gly 
1           


<210>  22
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Ser Pro Gly 
1           


<210>  23
<211>  1368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  25
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  26
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro 
1               5                   10                  15      


Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile 
            20                  25                  30          


Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg 
        35                  40                  45              


Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val 
    50                  55                  60                  


Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr 
65                  70                  75                  80  


Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly 
                85                  90                  95      


Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu 
            100                 105                 110         


Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His 
        115                 120                 125             


Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe 
    130                 135                 140                 


Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala 
                165                 170                 175     


Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg 
            180                 185                 190         


Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu 
        195                 200                 205             


Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr 
    210                 215                 220                 


Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe 
225                 230                 235                 240 


Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val 
                245                 250                 255     


Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu 
            260                 265                 270         


Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg 
        275                 280                 285             


His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
    290                 295                 300     


<210>  27
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Ser Ser Gly Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser 
1               5                   10                  15      


Gly Leu Val Pro Leu Ser Leu Arg Gly Ser His 
            20                  25          


<210>  28
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Gly Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp Lys Arg Gln 
1               5                   10                  15      


Pro Val Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys Val Leu Lys 
            20                  25                  30          


Ser Leu Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly Gly Thr Leu 
        35                  40                  45              


Lys Tyr Val Glu Asp Val Thr Asn Val Val Arg Arg Asp Val Glu Lys 
    50                  55                  60                  


Trp Gly Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro Leu Gly Ser 
65                  70                  75                  80  


Ser Cys Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe His Arg Ile 
                85                  90                  95      


Leu Gln Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro Phe Phe Trp 
            100                 105                 110         


Ile Phe Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln Glu Thr Thr 
        115                 120                 125             


Thr Arg Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp Val Arg Gly 
    130                 135                 140                 


Arg Asp Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile Pro Gly Leu 
145                 150                 155                 160 


Lys Ser Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu Tyr Leu Gln 
                165                 170                 175     


Ala Gln Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys Val Asp Leu 
            180                 185                 190         


Leu Val Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe 
        195                 200                 205             


Ser Gln Asn Ser Leu Pro Leu 
    210                 215 


<210>  29
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  30
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
1               5                   10                  15      


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
            20                  25                  30          


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
        35                  40                  45              


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
    50                  55                  60                  


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
                85                  90                  95      


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
            100                 105                 110         


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
        115                 120                 125             


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
    130                 135                 140                 


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
145                 150                 155                 160 


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
                165                 170                 175     


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
            180                 185                 190         


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
        195                 200                 205             


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  32
<211>  80
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Pro Ala 
1               5                   10                  15      


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        35                  40                  45              


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
65                  70                  75                  80  


<210>  33
<211>  543
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro 
1               5                   10                  15      


Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile 
            20                  25                  30          


Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg 
        35                  40                  45              


Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val 
    50                  55                  60                  


Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr 
65                  70                  75                  80  


Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly 
                85                  90                  95      


Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu 
            100                 105                 110         


Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His 
        115                 120                 125             


Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe 
    130                 135                 140                 


Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala 
                165                 170                 175     


Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg 
            180                 185                 190         


Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu 
        195                 200                 205             


Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr 
    210                 215                 220                 


Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe 
225                 230                 235                 240 


Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val 
                245                 250                 255     


Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu 
            260                 265                 270         


Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg 
        275                 280                 285             


His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val Ser Ser Gly 
    290                 295                 300                 


Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser Gly Leu Val 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Gly Ser His Met Gly Pro Met Glu Ile Tyr Lys 
                325                 330                 335     


Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe 
            340                 345                 350         


Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly 
        355                 360                 365             


Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn 
    370                 375                 380                 


Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr 
385                 390                 395                 400 


Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp 
                405                 410                 415     


Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln 
            420                 425                 430         


Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu 
        435                 440                 445             


Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala 
    450                 455                 460                 


Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg 
465                 470                 475                 480 


Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr 
                485                 490                 495     


Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys 
            500                 505                 510         


Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro 
        515                 520                 525             


Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu 
    530                 535                 540             


<210>  34
<211>  1307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Ala Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  35
<211>  1228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Ala Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  36
<211>  1314
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Gly Ser Gly Met Ser 
1               5                   10                  15      


Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr Leu Arg 
            20                  25                  30          


Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys Ala Arg 
        35                  40                  45              


Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys Lys Ala 
    50                  55                  60                  


Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu Ile Leu 
65                  70                  75                  80  


Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser Asp Val 
                85                  90                  95      


Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys Asp Phe 
            100                 105                 110         


Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr Ile Lys 
        115                 120                 125             


Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile Asp Ala 
    130                 135                 140                 


Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln Ser Lys 
145                 150                 155                 160 


Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr Asp Ile 
                165                 170                 175     


Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr Thr Tyr 
            180                 185                 190         


Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser Asn Asp 
        195                 200                 205             


Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu Pro Lys 
    210                 215                 220                 


Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys Ala Pro 
225                 230                 235                 240 


Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu Glu Leu 
                245                 250                 255     


Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg Val Phe 
            260                 265                 270         


Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr Leu Asn 
        275                 280                 285             


Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys Phe Val 
    290                 295                 300                 


Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile Asn Leu 
305                 310                 315                 320 


Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys Met Ser 
                325                 330                 335     


Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser Phe Val 
            340                 345                 350         


Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met Gln Ser 
        355                 360                 365             


Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys Ser Ile 
    370                 375                 380                 


Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln Lys Leu 
385                 390                 395                 400 


Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr Asp Leu 
                405                 410                 415     


Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala Val Leu 
            420                 425                 430         


Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn Pro Ser 
        435                 440                 445             


Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala Lys Tyr 
    450                 455                 460                 


Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn Lys His 
465                 470                 475                 480 


Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala Asn Phe 
                485                 490                 495     


Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys Asp Asn 
            500                 505                 510         


Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys Asp Leu 
        515                 520                 525             


Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp Leu Leu 
    530                 535                 540                 


Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His Ile Ser 
545                 550                 555                 560 


Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His Phe Tyr 
                565                 570                 575     


Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val Pro Leu 
            580                 585                 590         


Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser Asp Glu 
        595                 600                 605             


Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly Trp Asp 
    610                 615                 620                 


Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys Asp Asp 
625                 630                 635                 640 


Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile Phe Asp 
                645                 650                 655     


Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys Ile Val 
            660                 665                 670         


Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe 
        675                 680                 685             


Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile Leu Arg 
    690                 695                 700                 


Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln Lys Gly 
705                 710                 715                 720 


Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe Ile Asp 
                725                 730                 735     


Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp Phe Gly 
            740                 745                 750         


Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu Phe Tyr 
        755                 760                 765             


Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn Ile Ser 
    770                 775                 780                 


Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr Leu Phe 
785                 790                 795                 800 


Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg Pro Asn 
                805                 810                 815     


Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Gln 
            820                 825                 830         


Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Lys 
        835                 840                 845             


Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala Ile Ala 
    850                 855                 860                 


Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu Tyr Asp 
865                 870                 875                 880 


Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe His Cys 
                885                 890                 895     


Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe Asn Asp 
            900                 905                 910         


Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His Ile Leu 
        915                 920                 925             


Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu Val Asp 
    930                 935                 940                 


Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile Gly Asn 
945                 950                 955                 960 


Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile Glu Lys 
                965                 970                 975     


Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn Ile Lys 
            980                 985                 990         


Glu Met Lys Glu Gly Tyr Leu Ser  Gln Val Val His Glu  Ile Ala Lys 
        995                 1000                 1005             


Leu Val  Ile Glu Tyr Asn Ala  Ile Val Val Phe Glu  Asp Leu Asn 
    1010                 1015                 1020             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Val Tyr 
    1025                 1030                 1035             


Gln Lys  Leu Glu Lys Met Leu  Ile Glu Lys Leu Asn  Tyr Leu Val 
    1040                 1045                 1050             


Phe Lys  Asp Asn Glu Phe Asp  Lys Thr Gly Gly Val  Leu Arg Ala 
    1055                 1060                 1065             


Tyr Gln  Leu Thr Ala Pro Phe  Glu Thr Phe Lys Lys  Met Gly Lys 
    1070                 1075                 1080             


Gln Thr  Gly Ile Ile Tyr Tyr  Val Pro Ala Gly Phe  Thr Ser Lys 
    1085                 1090                 1095             


Ile Cys  Pro Val Thr Gly Phe  Val Asn Gln Leu Tyr  Pro Lys Tyr 
    1100                 1105                 1110             


Glu Ser  Val Ser Lys Ser Gln  Glu Phe Phe Ser Lys  Phe Asp Lys 
    1115                 1120                 1125             


Ile Cys  Tyr Asn Leu Asp Lys  Gly Tyr Phe Glu Phe  Ser Phe Asp 
    1130                 1135                 1140             


Tyr Lys  Asn Phe Gly Asp Lys  Ala Ala Lys Gly Lys  Trp Thr Ile 
    1145                 1150                 1155             


Ala Ser  Phe Gly Ser Arg Leu  Ile Asn Phe Arg Asn  Ser Asp Lys 
    1160                 1165                 1170             


Asn His  Asn Trp Asp Thr Arg  Glu Val Tyr Pro Thr  Lys Glu Leu 
    1175                 1180                 1185             


Glu Lys  Leu Leu Lys Asp Tyr  Ser Ile Glu Tyr Gly  His Gly Glu 
    1190                 1195                 1200             


Cys Ile  Lys Ala Ala Ile Cys  Gly Glu Ser Asp Lys  Lys Phe Phe 
    1205                 1210                 1215             


Ala Lys  Leu Thr Ser Val Leu  Asn Thr Ile Leu Gln  Met Arg Asn 
    1220                 1225                 1230             


Ser Lys  Thr Gly Thr Glu Leu  Asp Tyr Leu Ile Ser  Pro Val Ala 
    1235                 1240                 1245             


Asp Val  Asn Gly Asn Phe Phe  Asp Ser Arg Gln Ala  Pro Lys Asn 
    1250                 1255                 1260             


Met Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Gly Leu 
    1265                 1270                 1275             


Lys Gly  Leu Met Leu Leu Gly  Arg Ile Lys Asn Asn  Gln Glu Gly 
    1280                 1285                 1290             


Lys Lys  Leu Asn Leu Val Ile  Lys Asn Glu Glu Tyr  Phe Glu Phe 
    1295                 1300                 1305             


Val Gln  Asn Arg Asn Asn 
    1310                 


<210>  37
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
actgcggaaa tttgagcgt                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
acgctcaaat ttccgcagt                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
aggcaatggc tgcacatgc                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
gcatgtgcag ccattgcct                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gacgcttggt tctgaggag                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
ctcctcagaa ccaagcgtc                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
tccggaaacg cattcctct                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
agaggaatgc gtttccgga                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
ccgcgtcagc ccggcccgg                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
ccgggccggg ctgacgcgg                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
cgactcccgc tgggcctct                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
agaggcccag cgggagtcg                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
ccgttgcgcg ctcgctctc                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gagagcgagc gcgcaacgg                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ccgcgcatcc tgccaggcc                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
ggcctggcag gatgcgcgg                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
ccaacttggc gcgtttcgg                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
ccgaaacgcg ccaagttgg                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
accacgcgtc cgagtccgg                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
ccggactcgg acgcgtggt                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
tgctcattgt ccctggaca                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
tgtccaggga caatgagca                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
ggacaccctg ctcattgtc                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gacaatgagc agggtgtcc                                                    19


<210>  61
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
accggcagcc tgcgcgtcc                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
ggacgcgcag gctgccggt                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
cgatgggcac ccactgctc                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
gagcagtggg tgcccatcg                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
ccttcacgtg gacgcgcag                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
ctgcgcgtcc acgtgaagg                                                    19


<210>  67
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
cgtgaaggtg gaagccttc                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
gaaggcttcc accttcacg                                                    19


<210>  69
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
ctccttggtc aggcgccgg                                                    19


<210>  70
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
ccggcgcctg accaaggag                                                    19


<210>  71
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
tggtcaggcg ccggttccg                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
cggaaccggc gcctgacca                                                    19


<210>  73
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
tagaggtcgc cttctcctc                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
gaggagaagg cgacctcta                                                    19


<210>  75
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
cgacgctcgg gtcgcggtg                                                    19


<210>  76
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
caccgcgacc cgagcgtcg                                                    19


<210>  77
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
atgctgtcgc cgcgcgggg                                                    19


<210>  78
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
ccccgcgcgg cgacagcat                                                    19


<210>  79
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
ctcaccctca ccggagcca                                                    19


<210>  80
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  80
tggctccggt gagggtgag                                                    19


<210>  81
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  81
ccgcaaactt tactcctta                                                    19


<210>  82
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  82
taaggagtaa agtttgcgg                                                    19


<210>  83
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  83
ctcctaagat tggcttcac                                                    19


<210>  84
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  84
gtgaagccaa tcttaggag                                                    19


<210>  85
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  85
ccggagccac tcctaagat                                                    19


<210>  86
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  86
atcttaggag tggctccgg                                                    19


<210>  87
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
ttctctaccc tacgtctca                                                    19


<210>  88
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
tgagacgtag ggtagagaa                                                    19


<210>  89
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  89
tacgtctcat tctccgcaa                                                    19


<210>  90
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
ttgcggagaa tgagacgta                                                    19


<210>  91
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  91
gctaggcctc cagcccttc                                                    19


<210>  92
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  92
gaagggctgg aggcctagc                                                    19


<210>  93
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  93
acaggtggcg ccgcaactt                                                    19


<210>  94
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  94
aagttgcggc gccacctgt                                                    19


<210>  95
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  95
agccggaggc gcgagagtc                                                    19


<210>  96
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  96
gactctcgcg cctccggct                                                    19


