                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas
 
<120>  T CELL RECEPTORS WITH MAGE-B2 SPECIFICITY AND USES THEREOF

<130>  UTFC.P1372WO

<150>  62/660,083
<151>  2018-04-19

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  1

Gly Val Tyr Asp Gly Glu Glu His Ser Val 
1               5                   10  


<210>  2
<211>  813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
atgaactatt ctccaggctt agtatctctg atactcttac tgcttggaag aacccgtgga       60

aattcagtga cccagatgga agggccagtg actctctcag aagaggcctt cctgactata      120

aactgcacgt acacagccac aggataccct tcccttttct ggtatgtcca atatcctgga      180

gaaggtctac agctcctcct gaaagccacg aaggctgatg acaagggaag caacaaaggt      240

tttgaagcca cataccgtaa agaaaccact tctttccact tggagaaagg ctcagttcaa      300

gtgtcagact cagcggtgta cttctgtgct ctgaccaacg actacaagct cagctttgga      360

gccggaacca cagtaactgt aagagcaaat atccagaacc ctgaccctgc cgtgtaccag      420

ctgagagact ctaaatccag tgacaagtct gtctgcctat tcaccgattt tgattctcaa      480

acaaatgtgt cacaaagtaa ggattctgat gtgtatatca cagacaaaac tgtgctagac      540

atgaggtcta tggacttcaa gagcaacagt gctgtggcct ggagcaacaa atctgacttt      600

gcatgtgcaa acgccttcaa caacagcatt attccagaag acaccttctt ccccagccca      660

gaaagttcct gtgatgtcaa gctggtcgag aaaagctttg aaacagatac gaacctaaac      720

tttcaaaacc tgtcagtgat tgggttccga atcctcctcc tgaaagtggc cgggtttaat      780

ctgctcatga cgctgcggct gtggtccagc tga                                   813


<210>  3
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  3

Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln Leu Leu 
1               5                   10                  15      


Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly Phe Glu 
            20                  25                  30          


Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys Gly Ser 
        35                  40                  45              


Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Thr Asn Asp 
    50                  55                  60                  


Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn 
65                  70                  75                  80  


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
                85                  90                  95      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            100                 105                 110         


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        115                 120                 125             


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    130                 135                 140                 


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
145                 150                 155                 160 


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                165                 170                 175     


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            180                 185                 190         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        195                 200                 205             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    210                 215                 220 


<210>  4
<211>  930
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
atgggtcctg ggcttctcca ctggatggcc ctttgtctcc ttggaacagg tcatggggat       60

gccatggtca tccagaaccc aagataccag gttacccagt ttggaaagcc agtgaccctg      120

agttgttctc agactttgaa ccataacgtc atgtactggt accagcagaa gtcaagtcag      180

gccccaaagc tgctgttcca ctactatgac aaagatttta acaatgaagc agacacccct      240

gataacttcc aatccaggag gccgaacact tctttctgct ttcttgacat ccgctcacca      300

ggcctggggg acgcagccat gtacctgtgt gccaccagca ggggcgggag gtacaatgag      360

cagttcttcg ggccagggac acggctcacc gtgctagagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg      900

atggccatgg tcaagagaaa ggatttctga                                       930


<210>  5
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  5

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  6
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
gccacaggat acccttcc                                                     18


<210>  7
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  7

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gccacgaagg ctgatgacaa g                                                 21


<210>  9
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  9

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  10
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gctctgacca acgactacaa gctcagc                                           27


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  11

Ala Leu Thr Asn Asp Tyr Lys Leu Ser 
1               5                   


<210>  12
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
ttgaaccata acgtc                                                        15


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  13

Leu Asn His Asn Val 
1               5   


<210>  14
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
tactatgaca aagatttt                                                     18


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  15

Tyr Tyr Asp Lys Asp Phe 
1               5       


<210>  16
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
gccaccagca ggggcgggag gtacaatgag cagttc                                 36


<210>  17
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  17

Ala Thr Ser Arg Gly Gly Arg Tyr Asn Glu Gln Phe 
1               5                   10          


<210>  18
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha Chain (TRAV10*01)

<400>  18
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

actgggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgtgtggtga tttcaggctt tcagaaactt      360

gtatttggaa ctggcacccg acttctggtc agtccaaata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaaaact      540

gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

gggtttaatc tgctcatgac gctgcggctg tggtccagct aa                         822


<210>  19
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha Chain

<400>  19

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ile Ser Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  20
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta Chain (TRBV11-3*04)

<400>  20
atgggtacca ggctcctctg ctgggtggcc ttctgtctcc tggtggaaga actcatagaa       60

gctggagtgg ttcagtctcc cagatataag attatagaga aaaaacagcc tgtggctttt      120

tggtgcaatc ctatttctgg ccacaatacc ctttactggt accggcagaa cttgggacag      180

ggcccggagc ttctgattcg atatgagaat gaggaagcag tagacgattc acagttgcct      240

aaggatcgat tttctgcaga gaggctcaaa ggagtagact ccactctcaa gatccagcct      300

gcagagcttg gggactcggc cgtgtatctc tgtgccagca gcttccctaa acagggatcc      360

tacaatgagc agttcttcgg gccagggaca cggctcaccg tgctagagga cctgaaaaac      420

gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa      480

aaggccacac tggtgtgcct ggccacaggc ttcttccctg accacgtgga gctgagctgg      540

tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg acccgcagcc cctcaaggag      600

cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc      660

ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag      720

aatgacgagt ggacccagga tagggccaaa cccgtcaccc agatcgtcag cgccgaggcc      780

tggggtagag cagactgtgg ctttacctcg gtgtcctacc agcaaggggt cctgtctgcc      840

accatcctct atgagatcct gctagggaag gccaccctgt atgctgtgct ggtcagcgcc      900

cttgtgttga tggccatggt caagagaaag gatttctaa                             939


<210>  21
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta Chain

<400>  21

Met Gly Thr Arg Leu Leu Cys Trp Val Ala Phe Cys Leu Leu Val Glu 
1               5                   10                  15      


Glu Leu Ile Glu Ala Gly Val Val Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Lys Gln Pro Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Asn Thr Leu Tyr Trp Tyr Arg Gln Asn Leu Gly Gln Gly Pro Glu Leu 
    50                  55                  60                  


Leu Ile Arg Tyr Glu Asn Glu Glu Ala Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Glu Leu Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Phe Pro Lys Gln Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha Chain CDR1

<400>  22
gtgagcccct tcagcaac                                                     18


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain CDR1

<400>  23

Val Ser Pro Phe Ser Asn 
1               5       


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain CDR2

<400>  24
atgactttca gtgagaacac a                                                 21


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain CDR2

<400>  25

Met Thr Phe Ser Glu Asn Thr 
1               5           


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chai CDR3

<400>  26
gtggtgattt caggctttca gaaacttgta                                        30


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain CDR3

<400>  27

Val Val Ile Ser Gly Phe Gln Lys Leu Val 
1               5                   10  


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain CDR1

<400>  28
tctggccaca atacc                                                        15


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain CDR1

<400>  29

Ser Gly His Asn Thr 
1               5   


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain CDR2

<400>  30
tatgagaatg aggaagca                                                     18


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta hain CDR2

<400>  31

Tyr Glu Asn Glu Glu Ala 
1               5       


<210>  32
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain CDR3

<400>  32
gccagcagct tccctaaaca gggatcctac aatgagcagt tc                          42


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain CDR3

<400>  33

Ala Ser Ser Phe Pro Lys Gln Gly Ser Tyr Asn Glu Gln Phe 
1               5                   10                  


<210>  34
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain signal peptide

<400>  34
atgaactatt ctccaggctt agtatctctg atactcttac tgcttggaag aacccgt          57


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain signal peptide 3

<400>  35

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg 
            


<210>  36
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain variable region 2

<400>  36
ggaaattcag tgacccagat ggaagggcca gtgactctct cagaagaggc cttcctgact       60

ataaactgca cgtacacagc cacaggatac ccttcccttt tctggtatgt ccaatatcct      120

ggagaaggtc tacagctcct cctgaaagcc acgaaggctg atgacaaggg aagcaacaaa      180

ggttttgaag ccacataccg taaagaaacc acttctttcc acttggagaa aggctcagtt      240

caagtgtcag actcagcggt gtacttctgt gctctgacca acgactacaa gctcagcttt      300

ggagccggaa ccacagtaac tgtaagagca aatatc                                336


<210>  37
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain variable region 3

<400>  37

Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu Ser Glu Glu 
1               5                   10                  15      


Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly Tyr Pro Ser 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln Leu Leu Leu 
        35                  40                  45              


Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly Phe Glu Ala 
    50                  55                  60                  


Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys Gly Ser Val 
65                  70                  75                  80  


Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Thr Asn Asp Tyr 
                85                  90                  95      


Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn 
            100                 105                 110     


<210>  38
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain constant region 2

<400>  38
cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc       60

tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg      120

tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct      180

gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt      240

ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa      300

agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc      360

ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga      420


<210>  39
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain constant region 3

<400>  39

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  40
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain signal peptide 4

<400>  40
atgggtcctg ggcttctcca ctggatggcc ctttgtctcc ttggaacagg tcatggg          57


<210>  41
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain signal peptide 5

<400>  41

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly 
            


<210>  42
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain variable region 4

<400>  42
gatgccatgg tcatccagaa cccaagatac caggttaccc agtttggaaa gccagtgacc       60

ctgagttgtt ctcagacttt gaaccataac gtcatgtact ggtaccagca gaagtcaagt      120

caggccccaa agctgctgtt ccactactat gacaaagatt ttaacaatga agcagacacc      180

cctgataact tccaatccag gaggccgaac acttctttct gctttcttga catccgctca      240

ccaggcctgg gggacgcagc catgtacctg tgtgccacca gcaggggcgg gaggtacaat      300

gagcagttct tcgggccagg gacacggctc accgtgctag ag                         342


<210>  43
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain variable region 5

<400>  43

Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr Gln Phe Gly 
1               5                   10                  15      


Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His Asn Val Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu Leu Phe His 
        35                  40                  45              


Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro Asp Asn Phe 
    50                  55                  60                  


Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp Ile Arg Ser 
65                  70                  75                  80  


Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr Ser Arg Gly 
                85                  90                  95      


Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu 
        


<210>  44
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain constant region 4

<400>  44
gacctgaaaa acgtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc       60

tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttcttccc tgaccacgtg      120

gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac ggacccgcag      180

cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg      240

gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac      300

gggctctcgg agaatgacga gtggacccag gatagggcca aacccgtcac ccagatcgtc      360

agcgccgagg cctggggtag agcagactgt ggctttacct cggtgtccta ccagcaaggg      420

gtcctgtctg ccaccatcct ctatgagatc ctgctaggga aggccaccct gtatgctgtg      480

ctggtcagcg cccttgtgtt gatggccatg gtcaagagaa aggatttctg a               531


<210>  45
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain constant region 5

<400>  45

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175 


