                               SEQUENCE LISTING

<110> BAYLOR COLLEGE OF MEDICINE
 
<120> REPROGRAMMING CD4 T CELLS INTO CYTOTOXIC CD8 CELLS BY FORCED 
      EXPRESSION OF CD8AB AND CLASS 1 RESTRICTED T CELL RECEPTORS

<130> BAYM.P0258WO-1001068755

<140> PCT/US2019/028202
<141> 2019-04-18

<150> 62/659,971
<151> 2018-04-19

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ggccacggag cgagacaucu                                                   20


<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu 
1               5                   10  


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Asn Leu Thr His Val Leu Tyr Pro Val 
1               5                   


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Leu Met Leu Gly Glu Phe Leu Lys Leu 
1               5                   


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Asn Leu Thr His Val Leu Tyr Pro Val 
1               5                   


<210> 6
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> This region may or may not be present

<400> 6
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 7
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> This region may or may not be present

<400> 7
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 8
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> This region may or may not be present

<400> 8
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 9
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> This region may or may not be present

<400> 9
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 10
<211> 2150
<212> DNA
<213> Homo sapiens

<400> 10
gcgtcatggc cttaccagtg accgccttgc tcctgccgct ggccttgctg ctccacgccg       60

ccaggccgag ccagttccgg gtgtcgccgc tggatcggac ctggaacctg ggcgagacag      120

tggagctgaa gtgccaggtg ctgctgtcca acccgacgtc gggctgctcg tggctcttcc      180

agccgcgcgg cgccgccgcc agtcccacct tcctcctata cctctcccaa aacaagccca      240

aggcggccga ggggctggac acccagcggt tctcgggcaa gaggttgggg gacaccttcg      300

tcctcaccct gagcgacttc cgccgagaga acgagggctg ctatttctgc tcggccctga      360

gcaactccat catgtacttc agccacttcg tgccggtctt cctgccagcg aagcccacca      420

cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc      480

tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact      540

tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt      600

cactggttat caccctttac tgcaaccaca ggaaccgaag acgtgtttgc aaatgtcccc      660

ggcctgtggt caaatcggga gacaagccca gcctttcggc gagatacgtc taaccctgtg      720

caacagccac tacattactt caaactgaga tccttccttt tgagggagca agtccttccc      780

tttcattttt tccagtcttc ctccctgtgt attcattctc atgattatta ttttagtggg      840

ggcggggtgg gaaagattac tttttcttta tgtgtttgac gggaaacaaa actaggtaaa      900

atctacagta caccacaagg gtcacaatac tgttgtgcgc acatcgcggt agggcgtgga      960

aaggggcagg ccagagctac ccgcagagtt ctcagaatca tgctgagaga gctggaggca     1020

cccatgccat ctcaacctct tccccgcccg ttttacaaag ggggaggcta aagcccagag     1080

acagcttgat caaaggcaca cagcaagtca gggttggagc agtagctgga gggaccttgt     1140

ctcccagctc agggctcttt cctccacacc attcaggtct ttctttccga ggcccctgtc     1200

tcagggtgag gtgcttgagt ctccaacggc aagggaacaa gtacttcttg atacctggga     1260

tactgtgccc agagcctcga ggaggtaatg aattaaagaa gagaactgcc tttggcagag     1320

ttctataatg taaacaatat cagacttttt tttttataat caagcctaaa attgtataga     1380

cctaaaataa aatgaagtgg tgagcttaac cctggaaaat gaatccctct atctctaaag     1440

aaaatctctg tgaaacccct atgtggaggc ggaattgctc tcccagccct tgcattgcag     1500

aggggcccat gaaagaggac aggctacccc tttacaaata gaatttgagc atcagtgagg     1560

ttaaactaag gccctcttga atctctgaat ttgagataca aacatgttcc tgggatcact     1620

gatgactttt tatactttgt aaagacaatt gttggagagc ccctcacaca gccctggcct     1680

ctgctcaact agcagataca gggatgaggc agacctgact ctcttaagga ggctgagagc     1740

ccaaactgct gtcccaaaca tgcacttcct tgcttaaggt atggtacaag caatgcctgc     1800

ccattggaga gaaaaaactt aagtagataa ggaaataaga accactcata attcttcacc     1860

ttaggaataa tctcctgtta atatggtgta cattcttcct gattattttc tacacataca     1920

tgtaaaatat gtctttcttt tttaaatagg gttgtactat gctgttatga gtggctttaa     1980

tgaataaaca tttgtagcat cctctttaat gggtaaacag catccgaaaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2150


<210> 11
<211> 235
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Cys 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210> 12
<211> 705
<212> DNA
<213> Homo sapiens

<400> 12
gcgactgtct ccgccgagcc cccggggcca ggtgtcccgg gcgcgccacg atgcggccgc       60

ggctgtggct cctcttggcc gcgcagctga cagttctcca tggcaactca gtcctccagc      120

agacccctgc atacataaag gtgcaaacca acaagatggt gatgctgtcc tgcgaggcta      180

aaatctccct cagtaacatg cgcatctact ggctgagaca gcgccaggca ccgagcagtg      240

acagtcacca cgagttcctg gccctctggg attccgcaaa agggactatc cacggtgaag      300

aggtggaaca ggagaagata gctgtgtttc gggatgcaag ccggttcatt ctcaatctca      360

caagcgtgaa gccggaagac agtggcatct acttctgcat gatcgtcggg agccccgagc      420

tgaccttcgg gaagggaact cagctgagtg tggttgattt ccttcccacc actgcccagc      480

ccaccaagaa gtccaccctc aagaagagag tgtgccggtt acccaggcca gagacccaga      540

agggcctcaa ggggaaggtg tatcaggaac ctttgtcccc caatgcctgc atggatacta      600

cagcaatact acaacctcac agaagctgct taacccatgg atcctgaaaa cataggcaag      660

aagcacaggt cctgatgagt ggatctttac tacttttacc agatt                      705


<210> 13
<211> 198
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Leu Lys Gly Lys Val Tyr Gln Glu Pro Leu Ser 
                165                 170                 175     


Pro Asn Ala Cys Met Asp Thr Thr Ala Ile Leu Gln Pro His Arg Ser 
            180                 185                 190         


Cys Leu Thr His Gly Ser 
        195             


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 14
Gly Asp Val Glu Xaa Asn Pro Gly Pro 
1               5                   


