                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  Gene Therapy for Diseases Caused by Unbalanced Nucleotide Pools 
       including Mitochondrial DNA Depletion Syndromes

<130>  01001/006458-WO0

<140>  Filed Herewith
<141>  2019-04-18

<150>  62/659,281
<151>  2018-04-18

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ala Phe Cys Gln Arg Pro Ser Ser Asp Lys Glu Gln Glu Lys 
1               5                   10                  15      


Glu Lys Lys Ser Val Ile Cys Val Glu Gly Asn Ile Ala Ser Gly Lys 
            20                  25                  30          


Thr Thr Cys Leu Glu Phe Phe Ser Asn Ala Thr Asp Val Glu Val Leu 
        35                  40                  45              


Thr Glu Pro Val Ser Lys Trp Arg Asn Val Arg Gly His Asn Pro Leu 
    50                  55                  60                  


Gly Leu Met Tyr His Asp Ala Ser Arg Trp Gly Leu Thr Leu Gln Thr 
65                  70                  75                  80  


Tyr Val Gln Leu Thr Met Leu Asp Arg His Thr Arg Pro Gln Val Ser 
                85                  90                  95      


Ser Val Arg Leu Met Glu Arg Ser Ile His Ser Ala Arg Tyr Ile Phe 
            100                 105                 110         


Val Glu Asn Leu Tyr Arg Ser Gly Lys Met Pro Glu Val Asp Tyr Val 
        115                 120                 125             


Val Leu Ser Glu Trp Phe Asp Trp Ile Leu Arg Asn Met Asp Val Ser 
    130                 135                 140                 


Val Asp Leu Ile Val Tyr Leu Arg Thr Asn Pro Glu Thr Cys Tyr Gln 
145                 150                 155                 160 


Arg Leu Lys Lys Arg Cys Arg Glu Glu Glu Lys Val Ile Pro Leu Glu 
                165                 170                 175     


Tyr Leu Glu Ala Ile His His Leu His Glu Glu Trp Leu Ile Lys Gly 
            180                 185                 190         


Ser Leu Phe Pro Met Ala Ala Pro Val Leu Val Ile Glu Ala Asp His 
        195                 200                 205             


His Met Glu Arg Met Leu Glu Leu Phe Glu Gln Asn Arg Asp Arg Ile 
    210                 215                 220                 


Leu Thr Pro Glu Asn Arg Lys His Cys Pro 
225                 230                 


<210>  2
<211>  4678
<212>  DNA
<213>  Homo sapiens

<400>  2
gccaagttat gggtgcgttc tgccagcgtc ctagcagtga taaagaacag gaaaaagaga       60

aaaaatcagt gatctgtgtc gagggcaata ttgcaagtgg gaagacgaca tgcctggaat      120

tcttctccaa cgcgacagac gtcgaggtgt taacggagcc tgtgtccaag tggagaaatg      180

tccgtggcca caatcctctg ggcctgatgt accacgatgc ctctcgctgg ggtcttacgc      240

tacagactta tgtgcagctc accatgctgg acaggcatac tcgtcctcag gtgtcatctg      300

tacggttgat ggagaggtcg attcacagcg caagatacat ttttgtagaa aacctgtata      360

gaagtgggaa gatgccagaa gtggactatg tagttctgtc ggaatggttt gactggatct      420

tgaggaacat ggacgtgtct gttgatttga tagtttacct tcggaccaat cctgagactt      480

gttaccagag gttaaagaag agatgcaggg aagaggagaa ggtcattccg ctggaatacc      540

tggaagcaat tcaccatctc catgaggagt ggctcatcaa aggcagcctt ttccccatgg      600

cagcccctgt tctggtgatt gaggctgacc accacatgga gaggatgtta gaactctttg      660

aacaaaatcg ggatcgaata ttaactccag agaatcggaa gcattgccca taggaggcaa      720

aaggtctatg gctcatgtct gaaaaatgcc tgctgctgcc aagttagcta ttgggagcaa      780

tctggaaaaa cttgctccca ggagggcttt gtgtctggcc agcttgattt tcctaatggt      840

ctcatctcct ttgctagtgt ctttgtcatg cgtctctggc cctcgtgggt aaatgacaaa      900

cgggaccaat gggtttgcca agccctttgc tgttcgcagc ctcacattcc cccggtgcct      960

ctcccatggc tttgtgctgc tgagtcgctc tcatgaagcc cttagggaga gcacctgttg     1020

tgtgcctgac accacgctgg agctgtgtac caatcgtctc agccttcatt aggaggccga     1080

ggtaggagtc ttatatccca ggtgaggaat ttgaagctca gaaaggttga ggggctcccc     1140

agaggtcaca cagcctgtgt gcagtggagc tggcaccatt cagactttca gccgactcag     1200

caactttccc ttgccctggg ctgcctcctc ctgagagctg ttccccaccg ccctgcctct     1260

tccggttgga ggctctcatg tctctttggg gagagctggc agtgtgcgga gctgataaca     1320

ttttcccaat attgagcagt tcccaaggac agtcagcatt tctagacttc cacaaaatta     1380

tgctgcattt ggctggagcc cggtgttcag tggtttccct gcccgaggtc gctgcagccc     1440

catctaccac atcttcatgt ggacattgag attcacatgc tggctcctga agggtgctca     1500

gtctccttgg tgattaaggt cctgcttgaa ctgctgccaa ctccatgtca gggaagtcgc     1560

ttttggtgcc tggctggttt gcccagagcc aagctggggc aaggggcagc cagccctggc     1620

ttccaaggct cccgtactgt ctgtgtcctt gtataaggag ctttgctctt ggaattactg     1680

aaagtctgtg gcccaagaga gagacacaag tggccttaag tctttttgaa gtgttatttc     1740

atccagggaa atgcctcgag ccatagagcc tgaaatcatc tttgttggct cagaaaatac     1800

cttagcttca ctcagctgga ctgcattgaa ggcgaggctg ccccttggat caagcagaaa     1860

acaagagaaa gaaagaacgt tccctttggg gatagtctgg aaagttggga tttgcaaata     1920

aaggctctgg aagcattgct ggtcctgaag ctttggaggt gggcagagag agcttcaaga     1980

agactagatg caaaccctgg aaaggattaa ggctcaactc tggagaaaca ggccacagcc     2040

tctcagagca gctgttggct gtaaatagag gtagcaaggc cgctcccagg cccctgtgag     2100

tgtgggcacc tgtgcatgca atgctccgac tctgcagagg tgccaagtgc ccctgctggg     2160

ccagtcccag agagttagga agtcaaggcc tgcaactcct ggttcttcct gtttggacca     2220

gttcttgtgc cattggcagg atgagaggca gcagccaggc gggagctgtg tctagcagca     2280

cctgtagccc acgtgctgct aattagctgg aaaactggcg aaggcagaac ctttgctacc     2340

aggaatcttg acatgtgggg tctgtctttg agaatttgta aatgaacagt ccaatatttc     2400

ctctcggctc attttgcaca tccatttttg gggaaatgtg atttctctct cttttttttt     2460

tttttttttt gcctaaggca caatctcaag aggtcctgag accacgtacc catgattttt     2520

ttcttgctct gtgataccca ataactcctt cacctaagcc ctgttgttga ttttgaagtg     2580

cttcctaggc cagtgatttt agcttctgcc agctgctttt gccagtagat taacgtgttt     2640

ttatttttca aactccgtgt ttcctaacgt ggagtgtatg ggtctaagag agcctgctgt     2700

cctccctgcc ttccaccttg gagaggaggc tggacgcatc agcagtggcc agggcaggtc     2760

gcaaaatctc ccagcctaga gaccacacct gaaacggctg aagccagctt gcacaagggc     2820

tgctgtccct ctgcggcagg cagagctggt gggggcaggg gtcacagagc agtcatagac     2880

accatggacc agggcaggag aagggcagat ggcacatggg cacaacaggg ccttgtcctt     2940

agagcactgg ggggtcatgg ctgggagggg catggcaggg gctggcatcc ctgtagagcc     3000

agaggggcca cccagggcag tgacattcca gatatgttgg gctcacctca tccttgctgt     3060

gagactggag ttccatgggg acatgaagtc agtacaccgc agagctgctc agctgctcta     3120

cctctcgctg acttttttgt tgcacatata cattttcttt caattagcat ttatttcagc     3180

ttttatttaa gctttttgac agtacatgta aaatatatga ttataaccat ttaaaaatac     3240

cttatgtacc tggttttttt tggaaactag atagaaatat atttatcttt tacataaaag     3300

aagtgtgtag tggggtggtc cagggctttg tggtggctta gtggccatcg gggtcccagg     3360

ctcttcccac ctttctcttt tgggtccacc tcttggctcc tggcttcctt cctctggggc     3420

ctgactgtcc aggatggcag ctggagctcc tgctctgggc acggttggca tcagagccca     3480

ctgctcccca tccactcttt aatccagatg ctggtaatgt ccctttccaa ggcataacta     3540

agataagctg gaaggttctt acgaggcttt gctagaggcc ctgggaggtg gggggaaagg     3600

caagagggca gtgcccaccc atagaccggg tcacatgacc tggcatcagc gccgtggggt     3660

cctttgggct tcacctccct ctcccctctg cccccacgtc atcccaccct catcctcacc     3720

ctcaccattc ccatcccgta ccgtaatgtc ccttgcaagg cctaactctg tgaggaatga     3780

aaccacctca tccttgttcc aataacatga gtgaccgaat ttacaaacga gtgaatgtgg     3840

acctctggaa acattaccca gcttgttttt acttttcact ttctctttct gcccctttca     3900

tttccgtagg agccctttac ctagatgaga agtgtccccc cgcctgggga atatatcagt     3960

cagaacaatc ttcctgcaga catgcaccat tagacccgag tgacggtggt gccatttaaa     4020

cctcagagca ggtaaaaggt ggtcctgaaa cctgtctacc cacagggtgc tatggaatct     4080

gaatcacttc ttttttccta gagccctggg gtggggagct ccctcaagtg ttcacatgtg     4140

tgtggaatga ggaacaccca tctccttggc cctctccacc ctgaagagtt agttattaaa     4200

ataattggca agctcttgca aatgtcagtc atccattgtt cagaatggaa tagcaataat     4260

acatccctgg ctgccctggg cttggccagg attactcact gaaggcctca gggttactgg     4320

cacacacttt cttttcctaa taatcccatc ccctcagctt tcctaaggct agagtgaatt     4380

tcgtgttcct ttagtttaca taagatggtg aacttggcaa aagctatcat taaacagaag     4440

ctaagagaaa gcctatgtcg tggaatccag aatgggtatt gccattcact gctgtccaca     4500

gaagctgtct tgaatttctt tctgtgtctt ttcttttttt ttctttaaga ctgttgttta     4560

ccagactggg ctctgtggaa cacaggtgtc ctgggagatg gttaatcatt acaaaatatt     4620

ggtaacaatc taaagatgca tacataagag agtggtcaaa taaaccattt tccattca       4678


<210>  3
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Gly Arg Leu Phe Leu Ser Arg Leu Arg Ala Pro Phe Ser 
1               5                   10                  15      


Ser Met Ala Lys Ser Pro Leu Glu Gly Val Ser Ser Ser Arg Gly Leu 
            20                  25                  30          


His Ala Gly Arg Gly Pro Arg Arg Leu Ser Ile Glu Gly Asn Ile Ala 
        35                  40                  45              


Val Gly Lys Ser Thr Phe Val Lys Leu Leu Thr Lys Thr Tyr Pro Glu 
    50                  55                  60                  


Trp His Val Ala Thr Glu Pro Val Ala Thr Trp Gln Asn Ile Gln Ala 
65                  70                  75                  80  


Ala Gly Thr Gln Lys Ala Cys Thr Ala Gln Ser Leu Gly Asn Leu Leu 
                85                  90                  95      


Asp Met Met Tyr Arg Glu Pro Ala Arg Trp Ser Tyr Thr Phe Gln Thr 
            100                 105                 110         


Phe Ser Phe Leu Ser Arg Leu Lys Val Gln Leu Glu Pro Phe Pro Glu 
        115                 120                 125             


Lys Leu Leu Gln Ala Arg Lys Pro Val Gln Ile Phe Glu Arg Leu His 
    130                 135                 140                 


Phe Glu Ala Leu Met Asn Ile Pro Val Leu Val Leu Asp Val Asn Asp 
145                 150                 155                 160 


Asp Phe Ser Glu Glu Val Thr Lys Gln Glu Asp Leu Met Arg Glu Val 
                165                 170                 175     


Asn Thr Phe Val Lys Asn Leu 
            180             


<210>  4
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  4
aacggtgcgc tggagcgagt gagcagcgat acctagggcg gaagtgctct cggcggaagt       60

gatcgctgtg tgaatcgtgg gtgggatggc cgcgggccgc ctctttctaa gtcggcttcg      120

agcacccttc agttccatgg ccaagagccc actcgagggc gtttcctcct ccagaggcct      180

gcacgcgggg cgcgggcccc gaaggctctc catcgaaggc aacattgctg tgggaaagtc      240

cacgtttgtg aagttactca cgaaaactta cccagaatgg cacgtagcta cagaacctgt      300

agcaacatgg cagaatatcc aggctgctgg cacccaaaaa gcctgcactg cccaaagtct      360

tggaaacttg ctggatatga tgtaccggga gccagcacga tggtcctaca cattccagac      420

attttccttt ttgagccgcc tgaaagtaca gctggagccc ttccctgaga aactcttaca      480

ggccaggaag ccagtacaga tctttgagag gctccacttt gaggctctga tgaacattcc      540

agtgctggtg ttggatgtca atgatgattt ttctgaggaa gtaaccaaac aagaagacct      600

catgagagag gtaaacacct ttgtaaagaa tctgtaacca ataccatgaa gttcaggctg      660

tgatctgggc tccctgactt tctgaagcta gaaaaatgtt gtgtctccca accacctttc      720

catccccagc ccctctcatc cctggagcac tctgccgctc aagagctggt ttgttaatta      780

ttgttagact ttgccattgt tttcttttgt acctgaagca ttttgaaaat aaagtttact      840

taagttatgc ttgtttttct aaaaaaaaaa aaaaaaaaa                             879


<210>  5
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Leu Arg Leu Pro Pro His Arg Ser His Ala Ser Pro Leu 
1               5                   10                  15      


Asp Cys Lys Leu Gln Asp Arg Cys Arg Lys Cys Tyr Ser Pro Arg Ser 
            20                  25                  30          


Gly Gln Ala Cys Pro Pro Ala Leu Ala Ala Ala Trp Leu Arg Arg Cys 
        35                  40                  45              


Glu Arg Arg Gly Gly Arg Pro Arg Gly Gly Arg Arg Lys Glu Leu Thr 
    50                  55                  60                  


Leu Gly Leu Arg Pro Ala Arg Cys Ser Ala Pro Gly Pro Ala Lys Asp 
65                  70                  75                  80  


Asp Ala Trp Arg Pro Gln Ala Gly Arg Ser Ser Ser Asp Thr Asn Glu 
                85                  90                  95      


Ser Glu Ile Lys Ser Asn Glu Glu Pro Leu Leu Arg Lys Ser Ser Arg 
            100                 105                 110         


Arg Phe Val Ile Phe Pro Ile Gln Tyr Pro Asp Ile Trp Lys Met Tyr 
        115                 120                 125             


Lys Gln Ala Gln Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser 
    130                 135                 140                 


Lys Asp Leu Pro His Trp Asn Lys Leu Lys Ala Asp Glu Lys Tyr Phe 
145                 150                 155                 160 


Ile Ser His Ile Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn 
                165                 170                 175     


Glu Asn Leu Val Glu Arg Phe Ser Gln Glu Val Gln Val Pro Glu Ala 
            180                 185                 190         


Arg Cys Phe Tyr Gly Phe Gln Ile Leu Ile Glu Asn Val His Ser Glu 
        195                 200                 205             


Met Tyr Ser Leu Leu Ile Asp Thr Tyr Ile Arg Asp Pro Lys Lys Arg 
    210                 215                 220                 


Glu Phe Leu Phe Asn Ala Ile Glu Thr Met Pro Tyr Val Lys Lys Lys 
225                 230                 235                 240 


Ala Asp Trp Ala Leu Arg Trp Ile Ala Asp Arg Lys Ser Thr Phe Gly 
                245                 250                 255     


Glu Arg Val Val Ala Phe Ala Ala Val Glu Gly Val Phe Phe Ser Gly 
            260                 265                 270         


Ser Phe Ala Ala Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly 
        275                 280                 285             


Leu Thr Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys 
    290                 295                 300                 


Asp Phe Ala Cys Leu Met Phe Gln Tyr Leu Val Asn Lys Pro Ser Glu 
305                 310                 315                 320 


Glu Arg Val Arg Glu Ile Ile Val Asp Ala Val Lys Ile Glu Gln Glu 
                325                 330                 335     


Phe Leu Thr Glu Ala Leu Pro Val Gly Leu Ile Gly Met Asn Cys Ile 
            340                 345                 350         


Leu Met Lys Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Val Glu 
        355                 360                 365             


Leu Gly Phe Ser Lys Val Phe Gln Ala Glu Asn Pro Phe Asp Phe Met 
    370                 375                 380                 


Glu Asn Ile Ser Leu Glu Gly Lys Thr Asn Phe Phe Glu Lys Arg Val 
385                 390                 395                 400 


Ser Glu Tyr Gln Arg Phe Ala Val Met Ala Glu Thr Thr Asp Asn Val 
                405                 410                 415     


Phe Thr Leu Asp Ala Asp Phe 
            420             


<210>  6
<211>  4913
<212>  DNA
<213>  Homo sapiens

<400>  6
atgaggtaaa tgttgctgtt gcgtcttccc cctcaccgca gtcacgccag cccgttagat       60

tgcaagttgc aggaccgctg taggaaatgt tattcgccgc ggtcaggaca ggcctgtccg      120

cccgccctcg ccgcagcctg gcttcgtcgt tgcgagcgcc ggggaggccg tccccgggga      180

gggcggagga aggagctgac tttgggtttg cgtcccgctc gctgctctgc cccggggcca      240

gccaaggacg acgcttggag gcctcaggcc gggagatcat cttcagacac caacgaaagt      300

gaaataaagt caaatgaaga gccactccta agaaagagtt ctcgccggtt tgtcatcttt      360

ccaatccagt accctgatat ttggaaaatg tataaacagg cacaggcttc cttctggaca      420

gcagaagagg tcgacttatc aaaggatctc cctcactgga acaagcttaa agcagatgag      480

aagtacttca tctctcacat cttagccttt tttgcagcca gtgatggaat tgtaaatgaa      540

aatttggtgg agcgctttag tcaggaggtg caggttccag aggctcgctg tttctatggc      600

tttcaaattc tcatcgagaa tgttcactca gagatgtaca gtttgctgat agacacttac      660

atcagagatc ccaagaaaag ggaattttta tttaatgcaa ttgaaaccat gccctatgtt      720

aagaaaaaag cagattgggc cttgcgatgg atagcagata gaaaatctac ttttggggaa      780

agagtggtgg cctttgctgc tgtagaagga gttttcttct caggatcttt tgctgctata      840

ttctggctaa agaagagagg tcttatgcca ggactcactt tttccaatga actcatcagc      900

agagatgaag gacttcactg tgactttgct tgcctgatgt tccaatactt agtaaataag      960

ccttcagaag aaagggtcag ggagatcatt gttgatgctg tcaaaattga gcaggagttt     1020

ttaacagaag ccttgccagt tggcctcatt ggaatgaatt gcattttgat gaaacagtac     1080

attgagtttg tagctgacag attacttgtg gaacttggat tctcaaaggt ttttcaggca     1140

gaaaatcctt ttgattttat ggaaaacatt tctttagaag gaaaaacaaa tttctttgag     1200

aaacgagttt cagagtatca gcgttttgca gttatggcag aaaccacaga taacgtcttc     1260

accttggatg cagattttta aaaaacctct cgttttaaaa ctctataaac ttgtcattgg     1320

taaatagtag tctattttcc tctgcttaaa aaaaatttta agtatatcct ttaaaggact     1380

gggggtttgc tcaaaaggaa atccaaaacc tattctaaac aatttgcatt tatataattt     1440

tcctgtttaa caacaagagt gtgacctaaa tgcttttgtc ttgtcactga aataaaagat     1500

ggcattatgt ggttaagagc atggggcgag gggtcagaca tgagtctaag gttctgccct     1560

tactccagtg tgtgaccctt ggcaagtcag ttaatcttgg taaacctcgg tgtacttatc     1620

tttaaaatgg gagtaatagt aggtcctaaa ttcatagagt ggatattagg attaggatgc     1680

aaaaataaat gcttaaccaa cactactact gttagcacca ctactaatta tcattcattg     1740

ataatattaa ttgcaatgat gttgtaataa aatactctca tttccttaaa ataattgtga     1800

ttctaggtcc taggatctag aattagatct ttgtattttt aatgcttagg ggaagaatat     1860

aagtatctcc ttaaaaagaa cataattctc attcacgcaa gaataagttc tttgaattcc     1920

ttagtatgta gtgaagaaaa tttagttgtt agttgctttg ggaagcctac ttatggagtg     1980

gaaaccagga ggttatcatg gtagttgacc ttataagaaa aatgattctt cttcagaaat     2040

taaaaacata actattgcca gatttagctc tggaatgttt agaatcaggc tagaatagca     2100

ttttccaaag aatattctaa gagctattag ctcctctaga tatttttttg ggggaaaaag     2160

gggattctgt ggtcagatga gtttgggaaa tgctgaacac ttcattcttc tttagcaagt     2220

acagtcagta catcaaagac tgagcagttc agtggtacat aaatttatct cgccctgcat     2280

attcccaaca tacttaacac agatgttttt tacctgttaa catctcaccc agctagtgtt     2340

cctcagaaca aagattggaa aaagctggcc gagaaccatt tatacataga ggaagggctt     2400

atggactgag aaagggagaa catggtaggg attattgaat catttcaaat ttataccagc     2460

ctgaatagtg taccagcaat tgacttaggc tgtgtttctt tatggtttta aaactcttga     2520

gctgttataa gagatagttc ttttaatgtg actatgcaac atgatagcca atggtgaggg     2580

aaaaggaggt ttctctagaa gagtctgatg aaaggccggg aaccaaggtt tttgagaagt     2640

ctgcccctat ttatttttag taagtatcaa gaggtagcct gagcctagtt agagttagac     2700

ctgtctttgg atgaagaagt cttaatactg aaatactgaa tttttaatac attattattt     2760

ggtattctgt ataccccttc aagcagttgt ttcccattcc caacaaactg tactttatac     2820

aattctggat gctaaaactt agagattttc tctttgcata aattttggct ccattctttc     2880

cataacaatc taatcaaaac tgggagttct caagtgaatg caaaaggagc aggccataac     2940

tttatttgtt agatacactg tcagaaactt gagatctttt ggcctatgat aataccatta     3000

atttttgcat tgcttcagtt tgccaagtgt ttttacatca tctcatttga tctcaaaaca     3060

gcttgacaga gcaactgtta ttgaaatatt acagatggaa agaatgaggc tcagggaagt     3120

taaatgactt ggccaagatc tgctcatcgt cactgtctgt acagtatttt tttttagagg     3180

ttgtaatgtc tcagatttag tcctttacca tctatgttga tttgcttttg tctatttcct     3240

cattaattga atatacttta aatatatata ttaaagtatc aaaatataga gagacatttg     3300

aactgtattc aggtaatatg tttaaagata tttatatatt gccatacaaa aacttaacat     3360

ttaaaactga taatatctgt aatgacatca gaatgaaaga aaaaaaattg tacagtgtat     3420

attcctttgt tttgaatcca aatctttttc ataggtaatg acagatgcct taatgtgaag     3480

cttatttata atagcaataa acctaactgg atttggatga agaagtctta atactgacat     3540

actggatttt taatgcactg gtttgttatt tggtattcta tctctttttc caggcctcca     3600

ggttgcacat ttatttatta tgttcaatac tttggttctt agttcttaaa gaatcaagaa     3660

gttgtgtaat cttttaaaaa tattatcttg cagataaaga aaaaaattaa gagtgtgttt     3720

acaactgttt tctctttttt acagtacatg tatttaaatc attgctataa taaagttaag     3780

ttcattagga atataaaaac ttgcagttct atgatagatt gcatttatta aaaatgtttc     3840

attgtatcac atagaaatat ggccaggaag gacttgagaa gacagtttga tccattgctt     3900

ttagacagga ctgggttttg ctgtccaatt atatacaata atagtttttc ttacaactaa     3960

gctggcccca gccttgtctt gatattaata catgaaattt ttataattgt ctcattgtct     4020

catttagaaa catccatatt tttctgcttt ttctattgcc attttttatt tgtgcatgaa     4080

ttgattattg agaaaatgta gcagtttgca tatttaaaaa ttaatcattt tgcattttac     4140

atttaaatat gctaacatca ctgtcataga attcccaaat ttcatttgta gatactgaac     4200

taagggctaa tgtcaggagc tgatttttaa tgataaagct gcagatgggc taaataaaag     4260

ccaaattaat cctacaatca ggtattatgt ttttaaacca agttgagtga attggtagtg     4320

gacttgggaa atcttcccca gcagaatctg gatgaatggc acagaattga aatctctttg     4380

tttcccacca tttcccttta agtgctctgc tcctttgtaa aaagttaaag atttgaaaga     4440

gaatctcata ttcccgaggc attaggaaga aaggatttaa tcccttcaat ttggggctta     4500

atcttgttta aaaaaatgta agtgaagatg gaaggctgga gagaatgatt gctttttgta     4560

cagttaaata aggtcacaat attcttacat actttgtttt acaactgtgt tttcattttt     4620

tcaaatgtct ggccatttag caaagttatt tactatttac tgtgtacata gaaagcttta     4680

ttatgtgtgg tgtatctaaa ttttttttgc tgaaatacat tatggtcaat caagccaagc     4740

ctgcatgtac agaatttgtt tttttttcaa ataaattagt tgttttctta tttttttggc     4800

ttagtatgtt gaaataaact atggtatctt catcattttg tacatttcct ttttgaggaa     4860

ggtttcttta taagtgcaag ggctacccta ataaaggaat gtatatactt act            4913


<210>  7
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly 
1               5                   10                  15      


Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu 
            20                  25                  30          


Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg 
        35                  40                  45              


Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly 
    50                  55                  60                  


Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu 
65                  70                  75                  80  


Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala 
                85                  90                  95      


Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu 
            100                 105                 110         


Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val 
        115                 120                 125             


Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser 
    130                 135                 140                 


Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser 
145                 150                 155                 160 


Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu 
                165                 170                 175     


Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val 
            180                 185                 190         


Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val 
        195                 200                 205             


Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val 
    210                 215                 220                 


Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala 
225                 230                 235                 240 


Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val 
                245                 250                 255     


Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala 
            260                 265                 270         


Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu 
        275                 280                 285             


Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp 
    290                 295                 300                 


Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala 
305                 310                 315                 320 


Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp 
                325                 330                 335     


Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val 
            340                 345                 350         


Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg 
        355                 360                 365             


Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro 
    370                 375                 380                 


Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val 
385                 390                 395                 400 


Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg 
                405                 410                 415     


Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg 
            420                 425                 430         


Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser 
        435                 440                 445             


Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg 
    450                 455                 460                 


Ala Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro 
465                 470                 475                 480 


Gln Gln 
        


<210>  8
<211>  1679
<212>  DNA
<213>  Homo sapiens

<400>  8
cgactgccga gctccgccct ccaggcggcc ccacccgcct gccgtcctgg ggcgccgccg       60

ccccgccgcc ggcagtggac cgctgtgcgc gaaccctgaa ccctacggtc ccgacccgcg      120

ggcgaggccg ggtacctggg ctgggatccg gagcaagcgg gcgagggcag cgccctaagc      180

aggcatcccc gcaggcccgg agcgatggca gccttgatga ccccgggaac cggggcccca      240

cccgcgcctg gtgacttctc cggggaaggg agccagggac ttcccgaccc ttcgccagag      300

cccaagcagc tcccggagct gatccgcatg aagcgagacg gaggccgcct gagcgaagcg      360

gacatcaggg gcttcgtggc cgctgtggtg aatgggagcg cgcagggcgc acagatcggg      420

gccatgctga tggccatccg acttcggggc atggatctgg aggagacctc ggtgctgacc      480

caggccctgg ctcagtcggg acagcagctg gagtggccag aggcctggcg ccagcagctt      540

gtggacaagc attccacagg gggtgtgggt gacaaggtca gcctggtcct cgcacctgcc      600

ctggcggcat gtggctgcaa ggtgccaatg atcagcggac gtggtctggg gcacacagga      660

ggcaccttgg ataagctgga gtctattcct ggattcaatg tcatccagag cccagagcag      720

atgcaagtgc tgctggacca ggcgggctgc tgtatcgtgg gtcagagtga gcagctggtt      780

cctgcggacg gaatcctata tgcagccaga gatgtgacag ccaccgtgga cagcctgcca      840

ctcatcacag cctccattct cagtaagaaa ctcgtggagg ggctgtccgc tctggtggtg      900

gacgttaagt tcggaggggc cgccgtcttc cccaaccagg agcaggcccg ggagctggca      960

aagacgctgg ttggcgtggg agccagccta gggcttcggg tcgcggcagc gctgaccgcc     1020

atggacaagc ccctgggtcg ctgcgtgggc cacgccctgg aggtggagga ggcgctgctc     1080

tgcatggacg gcgcaggccc gccagactta agggacctgg tcaccacgct cgggggcgcc     1140

ctgctctggc tcagcggaca cgcggggact caggcccagg gcgctgcccg ggtggccgcg     1200

gcgctggacg acggctcggc ccttggccgc ttcgagcgga tgctggcggc gcagggcgtg     1260

gatcccggtc tggcccgagc cctgtgctcg ggaagtcccg cagaacgccg gcagctgctg     1320

cctcgcgccc gggagcagga ggagctgctg gcgcccgcag atggcaccgt ggagctggtc     1380

cgggcgctgc cgctggcgct ggtgctgcac gagctcgggg ccgggcgcag ccgcgctggg     1440

gagccgctcc gcctgggggt gggcgcagag ctgctggtcg acgtgggtca gaggctgcgc     1500

cgtgggaccc cctggctccg cgtgcaccgg gacggccccg cgctcagcgg cccgcagagc     1560

cgcgccctgc aggaggcgct cgtactctcc gaccgcgcgc cattcgccgc cccctcgccc     1620

ttcgcagagc tcgttctgcc gccgcagcaa taaagctcct ttgccgcgaa aaaaaaaaa      1679


<210>  9
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Ser Met Phe Tyr Gly Arg Leu Val Ala Val Ala Thr Leu 
1               5                   10                  15      


Arg Asn His Arg Pro Arg Thr Ala Gln Arg Ala Ala Ala Gln Val Leu 
            20                  25                  30          


Gly Ser Ser Gly Leu Phe Asn Asn His Gly Leu Gln Val Gln Gln Gln 
        35                  40                  45              


Gln Gln Arg Asn Leu Ser Leu His Glu Tyr Met Ser Met Glu Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gly Val Ser Val Pro Lys Gly Tyr Val Ala Lys Ser Pro 
65                  70                  75                  80  


Asp Glu Ala Tyr Ala Ile Ala Lys Lys Leu Gly Ser Lys Asp Val Val 
                85                  90                  95      


Ile Lys Ala Gln Val Leu Ala Gly Gly Arg Gly Lys Gly Thr Phe Glu 
            100                 105                 110         


Ser Gly Leu Lys Gly Gly Val Lys Ile Val Phe Ser Pro Glu Glu Ala 
        115                 120                 125             


Lys Ala Val Ser Ser Gln Met Ile Gly Lys Lys Leu Phe Thr Lys Gln 
    130                 135                 140                 


Thr Gly Glu Lys Gly Arg Ile Cys Asn Gln Val Leu Val Cys Glu Arg 
145                 150                 155                 160 


Lys Tyr Pro Arg Arg Glu Tyr Tyr Phe Ala Ile Thr Met Glu Arg Ser 
                165                 170                 175     


Phe Gln Gly Pro Val Leu Ile Gly Ser Ser His Gly Gly Val Asn Ile 
            180                 185                 190         


Glu Asp Val Ala Ala Glu Ser Pro Glu Ala Ile Ile Lys Glu Pro Ile 
        195                 200                 205             


Asp Ile Glu Glu Gly Ile Lys Lys Glu Gln Ala Leu Gln Leu Ala Gln 
    210                 215                 220                 


Lys Met Gly Phe Pro Pro Asn Ile Val Glu Ser Ala Ala Glu Asn Met 
225                 230                 235                 240 


Val Lys Leu Tyr Ser Leu Phe Leu Lys Tyr Asp Ala Thr Met Ile Glu 
                245                 250                 255     


Ile Asn Pro Met Val Glu Asp Ser Asp Gly Ala Val Leu Cys Met Asp 
            260                 265                 270         


Ala Lys Ile Asn Phe Asp Ser Asn Ser Ala Tyr Arg Gln Lys Lys Ile 
        275                 280                 285             


Phe Asp Leu Gln Asp Trp Thr Gln Glu Asp Glu Arg Asp Lys Asp Ala 
    290                 295                 300                 


Ala Lys Ala Asn Leu Asn Tyr Ile Gly Leu Asp Gly Asn Ile Gly Cys 
305                 310                 315                 320 


Leu Val Asn Gly Ala Gly Leu Ala Met Ala Thr Met Asp Ile Ile Lys 
                325                 330                 335     


Leu His Gly Gly Thr Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala 
            340                 345                 350         


Thr Val His Gln Val Thr Glu Ala Phe Lys Leu Ile Thr Ser Asp Lys 
        355                 360                 365             


Lys Val Leu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Met Arg Cys 
    370                 375                 380                 


Asp Val Ile Ala Gln Gly Ile Val Met Ala Val Lys Asp Leu Glu Ile 
385                 390                 395                 400 


Lys Ile Pro Val Val Val Arg Leu Gln Gly Thr Arg Val Asp Asp Ala 
                405                 410                 415     


Lys Ala Leu Ile Ala Asp Ser Gly Leu Lys Ile Leu Ala Cys Asp Asp 
            420                 425                 430         


Leu Asp Glu Ala Ala Arg Met Val Val Lys Leu Ser Glu Ile Val Thr 
        435                 440                 445             


Leu Ala Lys Gln Ala His Val Asp Val Lys Phe Gln Leu Pro Ile 
    450                 455                 460             


<210>  10
<211>  2182
<212>  DNA
<213>  Homo sapiens

<400>  10
ccgcctgtcg cctgtgcgcc tgcgcgcggc gccgagggga cggggtccga ctcagaaatg       60

gcggcctcca tgttctacgg caggctagtg gccgtggcca cccttcggaa ccaccggcct      120

cggacggccc agcgggctgc tgctcaggtt ctgggaagtt ctggattgtt taataaccat      180

ggactccaag tacagcagca acagcaaagg aatctctcac tacatgaata catgagtatg      240

gaattattgc aagaagctgg tgtctccgtt cccaaaggat atgtggcaaa gtcaccagat      300

gaagcttatg caattgccaa aaaattaggt tcaaaagatg tcgtgataaa ggcacaggtt      360

ttagctggtg gtagaggaaa aggaacattt gaaagtggcc tcaaaggagg agtgaagata      420

gttttctctc cagaagaagc aaaagctgtt tcttcacaaa tgattgggaa aaaattgttt      480

accaagcaaa cgggagaaaa gggcagaata tgcaatcaag tattggtctg tgagcgaaaa      540

tatcccagga gagaatacta ctttgcaata acaatggaaa ggtcatttca aggtcctgta      600

ttaataggaa gttcacatgg tggtgtcaac attgaagatg ttgctgctga gtctcctgaa      660

gcaataatta aagaacctat tgatattgaa gaaggcatca aaaaggaaca agctctccag      720

cttgcacaga agatgggatt tccacctaat attgtggaat cagcagcaga aaacatggtc      780

aagctttaca gcctttttct gaaatacgat gcaaccatga tagaaataaa tccaatggtg      840

gaagattcag atggagctgt attgtgtatg gatgcaaaga tcaattttga ctctaattca      900

gcctatcgcc aaaagaaaat ctttgatcta caggactgga cccaggaaga tgaaagggac      960

aaagatgctg ctaaggcaaa tctcaactac attggcctcg atggaaatat aggctgccta     1020

gtaaatggtg ctggtttggc tatggccaca atggatataa taaaacttca tggagggact     1080

ccagccaact tccttgatgt tggtggtggt gctacagtcc atcaagtaac agaagcattt     1140

aagcttatca cttcagataa aaaggtactg gctattctgg tcaacatttt tggaggaatc     1200

atgcgctgtg atgttattgc acagggtata gtcatggcag taaaagactt ggaaattaaa     1260

atacctgttg tggtacggtt acaaggtaca cgagtcgatg atgctaaggc actgatagcg     1320

gacagtggac ttaaaatact tgcttgtgat gacttggatg aagctgctag aatggttgta     1380

aagctctctg aaatagtgac cttagcgaag caagcacatg tggatgtgaa atttcagttg     1440

ccaatatgat ctgaaaaccc agtggatggc tgaaggtgtt aaatgtgcta taatcattaa     1500

gaatactgtg ttctgtgtta ttgttctttt tctttttagt gtgtggagat tgtaattgcc     1560

atctaggcac acaaacattt aaaaggattt ggactgcatt taattgtacc attcagaatg     1620

gactgtttgt acgaagcatg tataatgcag ttatcttctt tcttttgtcg cagccagtct     1680

tttttgcttc tcctacaaaa cgtaacttgc aatttgccag tttattattg ttggatacaa     1740

agttcttcat tgataagagt cctataaata agataaatac gaagataaag ctttattctt     1800

tagtgttaaa atacagtata tctaataact agcctcatta gtagagcagt atattaaaac     1860

aatgttttat gtaaaaagtg tttatcttca gcaccaaata catgataaat gtatcaatca     1920

ctatttataa acagagcttt caaacactcc tcagaatatt cttctaagta ttttgatgaa     1980

gtaactttgt aattatttga acattgtttt aatcattagg aaacactgat taactgcaag     2040

tcttcatgat tctgtcatat taagaaacac ctgtaggttt gcttcaaata aaggcatata     2100

taccaaggac ttacagacaa aattaagaat gtcaatttaa gttaataaaa atctcccaat     2160

atgaaaaaaa aaaaaaaaaa aa                                              2182


<210>  11
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Ala Thr Leu Ala Ala Ala Ala Asp Ile Ala Thr Met Val Ser 
1               5                   10                  15      


Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg Ser Phe Leu 
            20                  25                  30          


Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala Ser Arg Gln 
        35                  40                  45              


His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln Gly Phe Thr 
    50                  55                  60                  


Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu Tyr Gly Thr 
65                  70                  75                  80  


Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Gln Thr His Leu 
                85                  90                  95      


Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu Gln Thr Gly 
            100                 105                 110         


Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala Ala Ala Ala 
        115                 120                 125             


Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val Cys Ile Thr 
    130                 135                 140                 


Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His Lys Leu Leu 
145                 150                 155                 160 


Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
                165                 170                 175     


Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His Ile His Lys 
            180                 185                 190         


Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
        195                 200                 205             


Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser Leu Cys Val 
    210                 215                 220                 


Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile Asp Cys Leu 
225                 230                 235                 240 


Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile Leu Ile Gly 
                245                 250                 255     


Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe Leu Lys Gln 
            260                 265                 270         


His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe Ile Ala Gly 
        275                 280                 285             


Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Ile 
    290                 295                 300                 


Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala Leu Gln Ser 
305                 310                 315                 320 


Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly Thr Thr Ile 
                325                 330                 335     


Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
            340                 345     


<210>  12
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  12
gtcattggcg tatgaccgca acccttgccg ctgccgctga catcgctacc atggtctccg       60

gcagcagcgg cctcgccgcc gcccgtctcc tgtcgcgcag cttcctcctg ccgcagaatg      120

gaattcggca ttgttcctac acagcttctc ggcaacatct ctatgttgat aaaaatacaa      180

agattatttg ccagggtttc actggcaaac agggcacctt tcacagccag caggcattgg      240

aatatggcac caaactcgtt ggaggaacca ctccagggaa aggaggccag acacatctgg      300

gcttacctgt ctttaatact gtgaaggagg ccaaagaaca gacaggagca acggcttctg      360

tcatttatgt tcctccgcct tttgctgctg ctgccattaa tgaagctatt gaggcagaaa      420

ttcccttggt tgtgtgtatc actgaaggaa ttccccagca ggacatggta cgagtcaagc      480

acaaactgct gcgccaggaa aagacaaggc taattgggcc caactgccct ggagtcatca      540

atcctggaga atgtaaaatt ggcatcatgc ctggccatat tcacaaaaaa ggaaggattg      600

gcattgtgtc cagatctggc accctgactt atgaagcagt tcaccaaaca acgcaagttg      660

gattggggca gtctttgtgc gttggcattg gaggtgatcc ttttaatgga acagatttta      720

ttgactgcct cgaaatcttt ttgaacgatt ctgccacaga aggcatcata ttgattggtg      780

aaattggtgg taatgcagaa gagaatgctg cagaattttt gaagcaacat aattcaggtc      840

caaattccaa gcctgtagtg tccttcattg ctggtttaac tgctcctcct gggagaagaa      900

tgggtcatgc cggggcaatt attgctggag gaaaaggtgg agctaaagag aagatctctg      960

cccttcagag tgcaggagtt gtggtcagta tgtctcctgc acagctggga accacgatct     1020

acaaggaatt tgaaaagagg aagatgctat gaaagaaaaa aaaaattcct aaaactgtgg     1080

aatggatcac gtagacatgt aacccagcag cagtttgctt ctgttgtcca ctgattaatc     1140

agcctatgtg cctgacactg gtcttgcagt acaactggaa gccaaaacaa ggtggaagat     1200

gtcctgaatt aagatgtttt caccacattg tattacagag acagccaata aatctactat     1260

ttgatttcaa                                                            1270


<210>  13
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Leu Trp Arg Ala Tyr Gln Arg Ala Leu Ala Ala His Pro Trp 
1               5                   10                  15      


Lys Val Gln Val Leu Thr Ala Gly Ser Leu Met Gly Leu Gly Asp Ile 
            20                  25                  30          


Ile Ser Gln Gln Leu Val Glu Arg Arg Gly Leu Gln Glu His Gln Arg 
        35                  40                  45              


Gly Arg Thr Leu Thr Met Val Ser Leu Gly Cys Gly Phe Val Gly Pro 
    50                  55                  60                  


Val Val Gly Gly Trp Tyr Lys Val Leu Asp Arg Phe Ile Pro Gly Thr 
65                  70                  75                  80  


Thr Lys Val Asp Ala Leu Lys Lys Met Leu Leu Asp Gln Gly Gly Phe 
                85                  90                  95      


Ala Pro Cys Phe Leu Gly Cys Phe Leu Pro Leu Val Gly Ala Leu Asn 
            100                 105                 110         


Gly Leu Ser Ala Gln Asp Asn Trp Ala Lys Leu Gln Arg Asp Tyr Pro 
        115                 120                 125             


Asp Ala Leu Ile Thr Asn Tyr Tyr Leu Trp Pro Ala Val Gln Leu Ala 
    130                 135                 140                 


Asn Phe Tyr Leu Val Pro Leu His Tyr Arg Leu Ala Val Val Gln Cys 
145                 150                 155                 160 


Val Ala Val Ile Trp Asn Ser Tyr Leu Ser Trp Lys Ala His Arg Leu 
                165                 170                 175     


<210>  14
<211>  1002
<212>  DNA
<213>  Homo sapiens

<400>  14
agttcctagg ccagcctgtc acgtgggagg gaggctcggc gctcaggaag catggcactc       60

tggcgggcat accagcgggc cctggccgct cacccgtgga aagtacaggt cctgacagct      120

gggtccctga tgggcctggg tgacattatc tcacagcagc tggtggagag gcggggtctg      180

caggaacacc agagaggccg gactctgacc atggtgtccc tgggctgtgg ctttgtgggc      240

cctgtggtag gaggctggta caaggttttg gatcggttca tccctggcac caccaaagtg      300

gatgcactga agaagatgtt gttggatcag gggggctttg ccccgtgttt tctaggctgc      360

tttctcccac tggtaggggc acttaatgga ctgtcagccc aggacaactg ggccaaacta      420

cagcgggatt atcctgatgc ccttatcacc aactactatc tatggcctgc tgtgcagtta      480

gccaacttct acctggtccc ccttcattac aggttggccg ttgtccaatg tgttgctgtt      540

atctggaact cctacctgtc ctggaaggca catcggctct aagcctgcct cactccatcg      600

tttccacctt gcagtgatgc agcttgaccc tggaacggtc agacaacctc ctcaaagtgg      660

gcataccagt ttccacgggg ttgggttgcc ggtcagagct taagaggact agcaccctgc      720

aatgcccctc ttcactctaa aatgtacact gactgcttta gagcccttga taatagtctt      780

attcccacca catactaggc actccataaa tatctgttga accttcatga ccttatcaac      840

tttacaccca tatcccagca aatgccactc atccccactc ttcatagaca catttgttac      900

tctaaccctg cctaggcttc ttgtagctcc agctctttag agactcccgg aaccctttat      960

atggtgcctc agtaaatatg ttattaaata tgtaatccgg aa                        1002


<210>  15
<211>  1239
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Arg Leu Leu Trp Arg Lys Val Ala Gly Ala Thr Val Gly Pro 
1               5                   10                  15      


Gly Pro Val Pro Ala Pro Gly Arg Trp Val Ser Ser Ser Val Pro Ala 
            20                  25                  30          


Ser Asp Pro Ser Asp Gly Gln Arg Arg Arg Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Pro Gln Val Leu Ser Ser 
    50                  55                  60                  


Glu Gly Gly Gln Leu Arg His Asn Pro Leu Asp Ile Gln Met Leu Ser 
65                  70                  75                  80  


Arg Gly Leu His Glu Gln Ile Phe Gly Gln Gly Gly Glu Met Pro Gly 
                85                  90                  95      


Glu Ala Ala Val Arg Arg Ser Val Glu His Leu Gln Lys His Gly Leu 
            100                 105                 110         


Trp Gly Gln Pro Ala Val Pro Leu Pro Asp Val Glu Leu Arg Leu Pro 
        115                 120                 125             


Pro Leu Tyr Gly Asp Asn Leu Asp Gln His Phe Arg Leu Leu Ala Gln 
    130                 135                 140                 


Lys Gln Ser Leu Pro Tyr Leu Glu Ala Ala Asn Leu Leu Leu Gln Ala 
145                 150                 155                 160 


Gln Leu Pro Pro Lys Pro Pro Ala Trp Ala Trp Ala Glu Gly Trp Thr 
                165                 170                 175     


Arg Tyr Gly Pro Glu Gly Glu Ala Val Pro Val Ala Ile Pro Glu Glu 
            180                 185                 190         


Arg Ala Leu Val Phe Asp Val Glu Val Cys Leu Ala Glu Gly Thr Cys 
        195                 200                 205             


Pro Thr Leu Ala Val Ala Ile Ser Pro Ser Ala Trp Tyr Ser Trp Cys 
    210                 215                 220                 


Ser Gln Arg Leu Val Glu Glu Arg Tyr Ser Trp Thr Ser Gln Leu Ser 
225                 230                 235                 240 


Pro Ala Asp Leu Ile Pro Leu Glu Val Pro Thr Gly Ala Ser Ser Pro 
                245                 250                 255     


Thr Gln Arg Asp Trp Gln Glu Gln Leu Val Val Gly His Asn Val Ser 
            260                 265                 270         


Phe Asp Arg Ala His Ile Arg Glu Gln Tyr Leu Ile Gln Gly Ser Arg 
        275                 280                 285             


Met Arg Phe Leu Asp Thr Met Ser Met His Met Ala Ile Ser Gly Leu 
    290                 295                 300                 


Ser Ser Phe Gln Arg Ser Leu Trp Ile Ala Ala Lys Gln Gly Lys His 
305                 310                 315                 320 


Lys Val Gln Pro Pro Thr Lys Gln Gly Gln Lys Ser Gln Arg Lys Ala 
                325                 330                 335     


Arg Arg Gly Pro Ala Ile Ser Ser Trp Asp Trp Leu Asp Ile Ser Ser 
            340                 345                 350         


Val Asn Ser Leu Ala Glu Val His Arg Leu Tyr Val Gly Gly Pro Pro 
        355                 360                 365             


Leu Glu Lys Glu Pro Arg Glu Leu Phe Val Lys Gly Thr Met Lys Asp 
    370                 375                 380                 


Ile Arg Glu Asn Phe Gln Asp Leu Met Gln Tyr Cys Ala Gln Asp Val 
385                 390                 395                 400 


Trp Ala Thr His Glu Val Phe Gln Gln Gln Leu Pro Leu Phe Leu Glu 
                405                 410                 415     


Arg Cys Pro His Pro Val Thr Leu Ala Gly Met Leu Glu Met Gly Val 
            420                 425                 430         


Ser Tyr Leu Pro Val Asn Gln Asn Trp Glu Arg Tyr Leu Ala Glu Ala 
        435                 440                 445             


Gln Gly Thr Tyr Glu Glu Leu Gln Arg Glu Met Lys Lys Ser Leu Met 
    450                 455                 460                 


Asp Leu Ala Asn Asp Ala Cys Gln Leu Leu Ser Gly Glu Arg Tyr Lys 
465                 470                 475                 480 


Glu Asp Pro Trp Leu Trp Asp Leu Glu Trp Asp Leu Gln Glu Phe Lys 
                485                 490                 495     


Gln Lys Lys Ala Lys Lys Val Lys Lys Glu Pro Ala Thr Ala Ser Lys 
            500                 505                 510         


Leu Pro Ile Glu Gly Ala Gly Ala Pro Gly Asp Pro Met Asp Gln Glu 
        515                 520                 525             


Asp Leu Gly Pro Cys Ser Glu Glu Glu Glu Phe Gln Gln Asp Val Met 
    530                 535                 540                 


Ala Arg Ala Cys Leu Gln Lys Leu Lys Gly Thr Thr Glu Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Pro Gln His Leu Pro Gly His Pro Gly Trp Tyr Arg Lys Leu 
                565                 570                 575     


Cys Pro Arg Leu Asp Asp Pro Ala Trp Thr Pro Gly Pro Ser Leu Leu 
            580                 585                 590         


Ser Leu Gln Met Arg Val Thr Pro Lys Leu Met Ala Leu Thr Trp Asp 
        595                 600                 605             


Gly Phe Pro Leu His Tyr Ser Glu Arg His Gly Trp Gly Tyr Leu Val 
    610                 615                 620                 


Pro Gly Arg Arg Asp Asn Leu Ala Lys Leu Pro Thr Gly Thr Thr Leu 
625                 630                 635                 640 


Glu Ser Ala Gly Val Val Cys Pro Tyr Arg Ala Ile Glu Ser Leu Tyr 
                645                 650                 655     


Arg Lys His Cys Leu Glu Gln Gly Lys Gln Gln Leu Met Pro Gln Glu 
            660                 665                 670         


Ala Gly Leu Ala Glu Glu Phe Leu Leu Thr Asp Asn Ser Ala Ile Trp 
        675                 680                 685             


Gln Thr Val Glu Glu Leu Asp Tyr Leu Glu Val Glu Ala Glu Ala Lys 
    690                 695                 700                 


Met Glu Asn Leu Arg Ala Ala Val Pro Gly Gln Pro Leu Ala Leu Thr 
705                 710                 715                 720 


Ala Arg Gly Gly Pro Lys Asp Thr Gln Pro Ser Tyr His His Gly Asn 
                725                 730                 735     


Gly Pro Tyr Asn Asp Val Asp Ile Pro Gly Cys Trp Phe Phe Lys Leu 
            740                 745                 750         


Pro His Lys Asp Gly Asn Ser Cys Asn Val Gly Ser Pro Phe Ala Lys 
        755                 760                 765             


Asp Phe Leu Pro Lys Met Glu Asp Gly Thr Leu Gln Ala Gly Pro Gly 
    770                 775                 780                 


Gly Ala Ser Gly Pro Arg Ala Leu Glu Ile Asn Lys Met Ile Ser Phe 
785                 790                 795                 800 


Trp Arg Asn Ala His Lys Arg Ile Ser Ser Gln Met Val Val Trp Leu 
                805                 810                 815     


Pro Arg Ser Ala Leu Pro Arg Ala Val Ile Arg His Pro Asp Tyr Asp 
            820                 825                 830         


Glu Glu Gly Leu Tyr Gly Ala Ile Leu Pro Gln Val Val Thr Ala Gly 
        835                 840                 845             


Thr Ile Thr Arg Arg Ala Val Glu Pro Thr Trp Leu Thr Ala Ser Asn 
    850                 855                 860                 


Ala Arg Pro Asp Arg Val Gly Ser Glu Leu Lys Ala Met Val Gln Ala 
865                 870                 875                 880 


Pro Pro Gly Tyr Thr Leu Val Gly Ala Asp Val Asp Ser Gln Glu Leu 
                885                 890                 895     


Trp Ile Ala Ala Val Leu Gly Asp Ala His Phe Ala Gly Met His Gly 
            900                 905                 910         


Cys Thr Ala Phe Gly Trp Met Thr Leu Gln Gly Arg Lys Ser Arg Gly 
        915                 920                 925             


Thr Asp Leu His Ser Lys Thr Ala Thr Thr Val Gly Ile Ser Arg Glu 
    930                 935                 940                 


His Ala Lys Ile Phe Asn Tyr Gly Arg Ile Tyr Gly Ala Gly Gln Pro 
945                 950                 955                 960 


Phe Ala Glu Arg Leu Leu Met Gln Phe Asn His Arg Leu Thr Gln Gln 
                965                 970                 975     


Glu Ala Ala Glu Lys Ala Gln Gln Met Tyr Ala Ala Thr Lys Gly Leu 
            980                 985                 990         


Arg Trp Tyr Arg Leu Ser Asp Glu  Gly Glu Trp Leu Val  Arg Glu Leu 
        995                 1000                 1005             


Asn Leu  Pro Val Asp Arg Thr  Glu Gly Gly Trp Ile  Ser Leu Gln 
    1010                 1015                 1020             


Asp Leu  Arg Lys Val Gln Arg  Glu Thr Ala Arg Lys  Ser Gln Trp 
    1025                 1030                 1035             


Lys Lys  Trp Glu Val Val Ala  Glu Arg Ala Trp Lys  Gly Gly Thr 
    1040                 1045                 1050             


Glu Ser  Glu Met Phe Asn Lys  Leu Glu Ser Ile Ala  Thr Ser Asp 
    1055                 1060                 1065             


Ile Pro  Arg Thr Pro Val Leu  Gly Cys Cys Ile Ser  Arg Ala Leu 
    1070                 1075                 1080             


Glu Pro  Ser Ala Val Gln Glu  Glu Phe Met Thr Ser  Arg Val Asn 
    1085                 1090                 1095             


Trp Val  Val Gln Ser Ser Ala  Val Asp Tyr Leu His  Leu Met Leu 
    1100                 1105                 1110             


Val Ala  Met Lys Trp Leu Phe  Glu Glu Phe Ala Ile  Asp Gly Arg 
    1115                 1120                 1125             


Phe Cys  Ile Ser Ile His Asp  Glu Val Arg Tyr Leu  Val Arg Glu 
    1130                 1135                 1140             


Glu Asp  Arg Tyr Arg Ala Ala  Leu Ala Leu Gln Ile  Thr Asn Leu 
    1145                 1150                 1155             


Leu Thr  Arg Cys Met Phe Ala  Tyr Lys Leu Gly Leu  Asn Asp Leu 
    1160                 1165                 1170             


Pro Gln  Ser Val Ala Phe Phe  Ser Ala Val Asp Ile  Asp Arg Cys 
    1175                 1180                 1185             


Leu Arg  Lys Glu Val Thr Met  Asp Cys Lys Thr Pro  Ser Asn Pro 
    1190                 1195                 1200             


Thr Gly  Met Glu Arg Arg Tyr  Gly Ile Pro Gln Gly  Glu Ala Leu 
    1205                 1210                 1215             


Asp Ile  Tyr Gln Ile Ile Glu  Leu Thr Lys Gly Ser  Leu Glu Lys 
    1220                 1225                 1230             


Arg Ser  Gln Pro Gly Pro 
    1235                 


<210>  16
<211>  4452
<212>  DNA
<213>  Homo sapiens

<400>  16
gcggaccggc cgggtggagg ccacacgcta ccccgaggct gcgtaggccg cgcgaagggg       60

gacgccgtgc cgtgggcctg gggtcggggg agcagcagac cgggaagcac cgatttgggg      120

tggaaggcag gcatggtcaa acccatttca ctgacaggag agcagagaca ggacgtgtct      180

ctctccacgt cttccagcca gtaaaagaag ccaagctgga gcccaaagcc aggtgttctg      240

actcccagcg tgggggtccc tgcaccaacc atgagccgcc tgctctggag gaaggtggcc      300

ggcgccaccg tcgggccagg gccggttcca gctccggggc gctgggtctc cagctccgtc      360

cccgcgtccg accccagcga cgggcagcgg cggcggcagc agcagcagca gcagcagcag      420

cagcagcaac agcagcctca gcagccgcaa gtgctatcct cggagggcgg gcagctgcgg      480

cacaacccat tggacatcca gatgctctcg agagggctgc acgagcaaat cttcgggcaa      540

ggaggggaga tgcctggcga ggccgcggtg cgccgcagcg tcgagcacct gcagaagcac      600

gggctctggg ggcagccagc cgtgcccttg cccgacgtgg agctgcgcct gccgcccctc      660

tacggggaca acctggacca gcacttccgc ctcctggccc agaagcagag cctgccctac      720

ctggaggcgg ccaacttgct gttgcaggcc cagctgcccc cgaagccccc ggcttgggcc      780

tgggcggagg gctggacccg gtacggcccc gagggggagg ccgtacccgt ggccatcccc      840

gaggagcggg ccctggtgtt cgacgtggag gtctgcttgg cagagggaac ttgccccaca      900

ttggcggtgg ccatatcccc ctcggcctgg tattcctggt gcagccagcg gctggtggaa      960

gagcgttact cttggaccag ccagctgtcg ccggctgacc tcatccccct ggaggtccct     1020

actggtgcca gcagccccac ccagagagac tggcaggagc agttagtggt ggggcacaat     1080

gtttcctttg accgagctca tatcagggag cagtacctga tccagggttc ccgcatgcgt     1140

ttcctggaca ccatgagcat gcacatggcc atctcagggc taagcagctt ccagcgcagt     1200

ctgtggatag cagccaagca gggcaaacac aaggtccagc cccccacaaa gcaaggccag     1260

aagtcccaga ggaaagccag aagaggccca gcgatctcat cctgggactg gctggacatc     1320

agcagtgtca acagtctggc agaggtgcac agactttatg taggggggcc tcccttagag     1380

aaggagcctc gagaactgtt tgtgaagggc accatgaagg acattcgtga gaacttccag     1440

gacctgatgc agtactgtgc ccaggacgtg tgggccaccc atgaggtttt ccagcagcag     1500

ctaccgctct tcttggagag gtgtccccac ccagtgactc tggccggcat gctggagatg     1560

ggtgtctcct acctgcctgt caaccagaac tgggagcgtt acctggcaga ggcacagggc     1620

acttatgagg agctccagcg ggagatgaag aagtcgttga tggatctggc caatgatgcc     1680

tgccagctgc tctcaggaga gaggtacaaa gaagacccct ggctctggga cctggagtgg     1740

gacctgcaag aatttaagca gaagaaagct aagaaggtga agaaggaacc agccacagcc     1800

agcaagttgc ccatcgaggg ggctggggcc cctggtgatc ccatggatca ggaagacctc     1860

ggcccctgca gtgaggagga ggagtttcaa caagatgtca tggcccgcgc ctgcttgcag     1920

aagctgaagg ggaccacaga gctcctgccc aagcggcccc agcaccttcc tggacaccct     1980

ggatggtacc ggaagctctg cccccggcta gacgaccctg catggacccc gggccccagc     2040

ctcctcagcc tgcagatgcg ggtcacacct aaactcatgg cacttacctg ggatggcttc     2100

cctctgcact actcagagcg tcatggctgg ggctacttgg tgcctgggcg gcgggacaac     2160

ctggccaagc tgccgacagg taccaccctg gagtcagctg gggtggtctg cccctacaga     2220

gccatcgagt ccctgtacag gaagcactgt ctcgaacagg ggaagcagca gctgatgccc     2280

caggaggccg gcctggcgga ggagttcctg ctcactgaca atagtgccat atggcaaacg     2340

gtagaagaac tggattactt agaagtggag gctgaggcca agatggagaa cttgcgagct     2400

gcagtgccag gtcaacccct agctctgact gcccgtggtg gccccaagga cacccagccc     2460

agctatcacc atggcaatgg accttacaac gacgtggaca tccctggctg ctggtttttc     2520

aagctgcctc acaaggatgg taatagctgt aatgtgggaa gcccctttgc caaggacttc     2580

ctgcccaaga tggaggatgg caccctgcag gctggcccag gaggtgccag tgggccccgt     2640

gctctggaaa tcaacaaaat gatttctttc tggaggaacg cccataaacg tatcagctcc     2700

cagatggtgg tgtggctgcc caggtcagct ctgccccgtg ctgtgatcag gcaccccgac     2760

tatgatgagg aaggcctcta tggggccatc ctgccccaag tggtgactgc cggcaccatc     2820

actcgccggg ctgtggagcc cacatggctc accgccagca atgcccggcc tgaccgagta     2880

ggcagtgagt tgaaagccat ggtgcaggcc ccacctggct acacccttgt gggtgctgat     2940

gtggactccc aagagctgtg gattgcagct gtgcttggag acgcccactt tgccggcatg     3000

catggctgca cagcctttgg gtggatgaca ctgcagggca ggaagagcag gggcactgat     3060

ctacacagta agacagccac tactgtgggc atcagccgtg agcatgccaa aatcttcaac     3120

tacggccgca tctatggtgc tgggcagccc tttgctgagc gcttactaat gcagtttaac     3180

caccggctca cacagcagga ggcagctgag aaggcccagc agatgtacgc tgccaccaag     3240

ggcctccgct ggtatcggct gtcggatgag ggcgagtggc tggtgaggga gttgaacctc     3300

ccagtggaca ggactgaggg tggctggatt tccctgcagg atctgcgcaa ggtccagaga     3360

gaaactgcaa ggaagtcaca gtggaagaag tgggaggtgg ttgctgaacg ggcatggaag     3420

gggggcacag agtcagaaat gttcaataag cttgagagca ttgctacgtc tgacatacca     3480

cgtaccccgg tgctgggctg ctgcatcagc cgagccctgg agccctcggc tgtccaggaa     3540

gagtttatga ccagccgtgt gaattgggtg gtacagagct ctgctgttga ctacttacac     3600

ctcatgcttg tggccatgaa gtggctgttt gaagagtttg ccatagatgg gcgcttctgc     3660

atcagcatcc atgacgaggt tcgctacctg gtgcgggagg aggaccgcta ccgcgctgcc     3720

ctggccttgc agatcaccaa cctcttgacc aggtgcatgt ttgcctacaa gctgggtctg     3780

aatgacttgc cccagtcagt cgcctttttc agtgcagtcg atattgaccg gtgcctcagg     3840

aaggaagtga ccatggattg taaaacccct tccaacccaa ctgggatgga aaggagatac     3900

gggattcccc agggtgaagc gctggatatt taccagataa ttgaactcac caaaggctcc     3960

ttggaaaaac gaagccagcc tggaccatag cactgcctgg aggctctgta tttgctcccg     4020

tggagcttca tcggggtggt gcaggctccc aaactcaggc tttcagctgt gctttttgca     4080

aaagggcttg cctaaggcca gccatttttc agtagcagga cctgccaaga agattccttc     4140

taactgaagg tgcagttgaa ttcagtgggt tcagaaccaa gatgccaaca tcggtgtgga     4200

ctacaggaca aggggcattg ttgcttgttg ggtaaaaatg aagcagaagc cccaaagttc     4260

acattaactc aggcatttca tttatttttt ccttttcttc ttggctggtt ctttgttctg     4320

tcccccatgc tctgatgcag tgccctagaa ggggaaagaa ttaatgctct aacgtgataa     4380

acctgctcca aggcagtgga aataaaaaga aggaaaaaaa agactctatc ttctcaaaaa     4440

aaaaaaaaaa aa                                                         4452


<210>  17
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  17
atgggagcat tttgccagcg acctagttcc gataaagaac aggagaaaga gaagaagagc       60

gtcatctgtg tggaaggtaa catcgctagt ggcaaaacga cctgtttgga atttttctct      120

aatgccaccg atgtggaggt gcttacagag cctgttagta aatggcgaaa tgttcgagga      180

cataatccgc tgggactgat gtatcacgat gcctccagat ggggactgac ccttcagact      240

tatgtccaac ttacaatgct tgacaggcac actagaccgc aggttagcag cgtgaggctg      300

atggagcgct caattcactc tgccaggtat atattcgttg agaacctcta ccgatctggt      360

aagatgcctg aggtagatta cgtagtgctg agtgaatggt ttgactggat tcttcgcaac      420

atggatgtat cagtggatct cattgtttac cttaggacta acccggagac gtgttatcag      480

cgcttgaaaa agcgctgccg ggaagaggaa aaagtgattc ctctggaata cttggaagct      540

attcatcacc ttcacgaaga gtggctgata aaaggttccc tgtttcccat ggcggccccc      600

gtgcttgtca tagaagcgga tcaccacatg gaaaggatgc tcgaactttt cgagcaaaat      660

cgagaccgga ttctcacgcc ggagaatcga aaacattgcc catag                      705


<210>  18
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  18
atggctgcag ggaggctttt tttgtctaga ttgagggcac cttttagctc catggcgaag       60

tctccgcttg agggggtgag tagcagccgg gggctccatg ctggcagagg gccccggagg      120

ctgtctattg aggggaatat tgcagttggt aagagcacgt ttgttaaatt gctcacgaag      180

acctatccag aatggcacgt tgctacagaa ccagtagcta catggcaaaa cattcaagca      240

gcaggcacac agaaggcttg cactgcacag tctctcggaa acctgctcga tatgatgtac      300

agagagcccg cccggtggtc atacacgttt cagaccttca gctttctttc tcggttgaag      360

gtacagttgg agcccttccc agagaagttg cttcaagcac ggaaacctgt acagatattc      420

gaacgattgc atttcgaggc gctgatgaac atacctgtgc ttgttctgga tgtgaacgac      480

gatttttccg aggaagttac taagcaagag gacctcatgc gggaggtaaa cacgttcgtt      540

aagaacctgt aa                                                          552


<210>  19
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  19
atggcagcat tgatgacacc aggaacgggg gctccgcctg cgcctggcga tttttcagga       60

gaggggagtc aaggtctgcc ggacccttca ccggaaccca aacagcttcc cgagcttatt      120

agaatgaagc gagatggggg tcgcctctct gaggctgaca tacgcggctt tgttgcggcg      180

gtcgtcaacg gctcagcaca aggtgcgcaa ataggagcga tgctgatggc tatcaggctg      240

aggggaatgg atttggaaga gaccagtgtg ctgactcaag cgctggcaca gagcggccag      300

cagcttgaat ggccagaagc ttggcgccaa caattggtcg ataaacactc aaccgggggc      360

gtcggggaca aagtctccct tgtactggca cctgctctgg ctgcgtgcgg atgtaaggtt      420

cctatgatta gcgggcgggg cttgggacat acgggaggaa cgttggacaa actcgaatcc      480

atccctggtt tcaacgtgat tcagagccct gaacaaatgc aagtactcct ggatcaggca      540

ggctgctgta ttgttggcca aagcgaacaa ctcgtgcctg cggatggtat cctctatgct      600

gccagggatg tgaccgccac agttgactcc ctcccgctga taacagcgtc aattttgagt      660

aagaagctcg tcgaagggct cagcgctctt gtggttgatg taaaatttgg gggggccgca      720

gtattcccca accaggaaca agcacgggaa ctggcaaaaa ccctggttgg tgtgggcgct      780

tcactgggcc tgagagttgc cgctgccttg accgccatgg ataagccgct cggtaggtgc      840

gtaggtcatg cacttgaagt agaagaagcc cttttgtgca tggatggggc cggtccccct      900

gacttgcggg atctcgtaac cacgcttggc ggcgcgttgc tttggctttc tggacacgct      960

ggtacccaag cgcaaggggc agcaagagtc gcagcagcgc ttgatgacgg atcagctctt     1020

gggcgatttg aaagaatgct tgcagctcag ggcgtagatc cagggctggc gcgggccctt     1080

tgctcaggtt ctccagcaga gcgccgacag ctccttccca gggcgcgaga gcaggaagaa     1140

ttgctggccc cggctgatgg taccgtcgaa ctcgtacggg ctttgccgct ggctcttgtt     1200

ttgcacgaac tgggggctgg gcggagtcgc gccggtgaac ctctcagact cggtgtgggt     1260

gcggagctcc tcgttgacgt cgggcaacga cttcgcaggg gaaccccttg gcttagggta     1320

cacagggacg ggccagcact cagcggccct cagtccaggg cccttcaaga agctctcgtg     1380

ctgagtgatc gagcgccttt tgccgctccc tcaccatttg ctgaattggt attgccaccc     1440

cagcagtaa                                                             1449


<210>  20
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  20
atgctgcttc tcagactgcc accccaccgc agtcatgctt ccccacttga ctgtaaactt       60

caagataggt gccggaagtg ttactcaccc cgatcaggac aagcgtgccc tcctgcgttg      120

gcggccgcct ggcttcggcg gtgtgaacgc cgaggaggtc ggccgagggg tgggcgacgc      180

aaggaactga cccttggcct gcgccctgca cggtgttcag ctcccggtcc tgccaaggat      240

gatgcatgga gacctcaggc aggtcgctcc tcctcagata ccaacgagag tgaaattaaa      300

tctaatgaag aaccccttct tcgcaagagt agtcgcaggt tcgtgatatt ccccatacaa      360

tatcctgata tctggaaaat gtacaagcaa gcccaagcat cattctggac cgcagaagag      420

gttgatctca gtaaggacct cccacactgg aacaaactga aagccgacga aaaatatttc      480

atatcccata tacttgcttt ctttgcagcc tcagatggaa ttgtgaatga aaacttggta      540

gagcgcttct ctcaagaggt ccaagttcct gaagcacgat gcttttacgg atttcaaatc      600

ctgatagaaa atgtacattc cgaaatgtat tccttgctta tagacacgta tatcagagat      660

cccaaaaaaa gggagttctt gttcaatgcg atcgagacca tgccatatgt taagaaaaaa      720

gccgattggg ccctgaggtg gatagctgat aggaagtcta catttgggga acgcgttgtt      780

gccttcgccg ccgtcgaggg agtcttcttc tccggatcct tcgctgctat cttttggctg      840

aaaaaacgcg gcttgatgcc tggtttgacc tttagcaatg agttgatatc acgggatgaa      900

gggctgcatt gtgactttgc ctgccttatg ttccagtact tggtgaacaa accgtctgag      960

gaacgggtaa gggaaatcat agtggatgca gtaaaaatag agcaggagtt ccttactgaa     1020

gcgctccccg tagggctcat tggcatgaac tgcattctta tgaagcagta catcgagttc     1080

gtggccgata gacttttggt ggagctcggg ttctcaaagg tttttcaggc tgaaaatcct     1140

tttgatttta tggagaacat atctctggag ggcaagacta acttttttga aaaaagagta     1200

tccgagtatc aaaggtttgc cgtgatggca gaaacaacag ataatgtctt cacacttgat     1260

gcggattttt aa                                                         1272


<210>  21
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  21
atggcggctt ctatgttcta tggacgcctg gtcgccgttg ccacgttgcg gaatcacagg       60

ccccgaactg cacaaagggc tgccgctcag gtgcttggaa gcagcggatt gttcaacaat      120

cacggcctcc aagttcagca acagcagcag agaaacctct ctctgcatga gtatatgagt      180

atggaactgc tccaggaagc aggggtgtct gtaccaaagg gctacgtagc aaaaagcccc      240

gacgaggcgt acgccatagc taaaaaactg ggaagtaagg acgtagttat caaagcacag      300

gttctggccg gtggccgcgg taagggaacc ttcgagagtg gtttgaaagg cggtgtcaag      360

atcgtattta gtcccgagga ggccaaggct gtaagttccc agatgatcgg caaaaaattg      420

ttcacaaagc aaaccggcga aaagggtaga atttgcaacc aagtacttgt ctgcgaaaga      480

aagtatccga gaagggagta ttatttcgct ataaccatgg aaagatcatt ccaaggtccc      540

gtgctcatcg gcagttcaca cgggggcgtt aatatagagg atgtcgctgc agagtctccg      600

gaggccataa ttaaggagcc tatagacatc gaggaaggca ttaaaaaaga acaagccttg      660

caactggcac aaaaaatggg ttttcctccg aacatcgtcg agagtgccgc agaaaatatg      720

gtgaaactgt acagcctgtt tttgaagtac gatgcgacaa tgatagaaat taatccgatg      780

gtcgaggact cagatggagc cgtgctttgt atggacgcca aaattaactt cgattcaaac      840

agcgcttatc gacagaagaa aattttcgat ttgcaagatt ggacccaaga ggatgagcga      900

gacaaagatg ccgccaaagc aaatctcaat tatataggac tcgatggtaa tattggatgt      960

ttggtcaatg gtgccggtct cgcgatggca actatggata taatcaagtt gcatggtggg     1020

actcccgcca actttcttga cgtcggggga ggcgccaccg ttcaccaagt tacggaggct     1080

ttcaaactca taacctctga caagaaggtg ctggcgattc ttgtaaatat ctttggtggc     1140

attatgcggt gtgatgttat tgcccaggga atagtaatgg ctgtcaaaga tttggagatt     1200

aaaatacccg tcgtggtgcg gctccaaggt actcgagtag atgatgctaa ggctctgatt     1260

gccgacagcg ggctgaagat tctggcatgt gatgatttgg acgaggcagc gagaatggtc     1320

gtgaagctct cagaaatagt aactttggcg aaacaggctc atgtcgatgt aaagttccaa     1380

cttcctatat ga                                                         1392


<210>  22
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  22
atgaccgcta cgcttgcggc tgcagccgac atcgcgacaa tggtctctgg aagttcaggc       60

ttggccgcgg ctcggcttct gagtagaagt ttcttgttgc cgcaaaacgg tatcaggcac      120

tgctcctaca ccgccagtag acaacacctt tatgttgata agaacacgaa gataatttgc      180

caaggattca ccggtaaaca ggggaccttc cattcccagc aggcactgga atatggaact      240

aaattggtag gcggcactac gcctgggaag ggtggccaaa cacatcttgg tcttcccgtt      300

tttaacacag tgaaggaggc taaagaacaa acgggggcaa cggctagcgt tatctatgtc      360

ccacccccgt ttgccgctgc agccataaat gaggcgattg aagccgagat cccgcttgta      420

gtctgcataa cggagggaat tccgcaacaa gacatggtgc gagtaaagca caagcttctt      480

cgacaggaaa aaacaagact gataggtccg aattgtcctg gcgtaattaa ccccggtgaa      540

tgcaaaatcg gaattatgcc gggacatatt cacaaaaaag gccgaatcgg gatagtcagc      600

agatcaggca ccttgacata cgaagcggtt caccagacta cgcaagtcgg tttgggacaa      660

agcctttgcg tcggtatcgg tggcgaccca tttaacggga cggatttcat tgactgtctg      720

gagatcttcc tcaacgattc cgcgacagaa ggaatcattt tgataggaga aataggcggg      780

aacgccgaag agaatgcagc ggaattcctc aaacaacata actctggccc taatagtaag      840

ccggtggtat cattcatagc cggtcttaca gcgccgccgg gtcgcagaat gggccacgca      900

ggtgcaatta tagcgggggg caagggaggt gccaaagaaa agatatccgc tcttcaaagc      960

gcaggtgtag tagttagtat gagtccagct caactgggca caaccatcta caaagaattt     1020

gaaaagcgga aaatgctttg a                                               1041


<210>  23
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  23
atggccctct ggagagctta ccaacgagcc ttggccgcgc acccttggaa ggtacaggtc       60

ttgaccgccg gatctttgat gggtcttgga gatattattt ctcaacagtt ggttgaacgg      120

cgaggcctcc aggaacacca aagggggaga acccttacaa tggtaagtct gggttgcgga      180

ttcgtcgggc ctgtcgtggg gggatggtat aaggttctgg atcgctttat accggggacc      240

accaaggtcg atgccttgaa gaagatgttg ctggatcagg gaggattcgc tccgtgtttt      300

ttgggatgtt ttctgccact tgttggggct ctgaacggac tgtccgcgca ggataactgg      360

gcgaagttgc aacgcgacta cccagacgcc ctgataacaa attactatct ctggccagca      420

gttcagttgg ccaattttta cctggtacct ctccactatc gccttgctgt agtacagtgt      480

gtcgccgtca tctggaactc atacctttca tggaaggctc atagattgta a               531


<210>  24
<211>  3720
<212>  DNA
<213>  Homo sapiens

<400>  24
atgtccaggc tgctctggcg gaaggtcgca ggcgccactg tcggtccagg accagttcca       60

gctcccggtc gctgggtgag cagcagcgtg ccagctagcg atccgagcga cggtcagcgg      120

cgacggcaac aacagcagca acagcaacaa cagcaacaac aacagcccca gcagcctcag      180

gttctcagtt ccgagggtgg ccaactccga cacaacccac tggatataca gatgctctcc      240

cgcggtctcc acgaacaaat attcggacaa gggggtgaga tgccgggaga ggctgcggtc      300

aggcgcagtg tagaacatct ccagaaacac gggttgtggg gccaaccggc cgttcctctc      360

cccgatgttg aactgcggct tccacctctc tacggtgata atctggacca gcactttaga      420

ctgctcgctc aaaagcagag tctcccttac ctggaagccg ctaacctcct gctccaagcc      480

caattgcccc ctaaaccgcc agcctgggct tgggcggagg gatggacgag gtatggaccc      540

gaaggggagg ctgtgccagt tgctatacca gaggaacgcg ctctggtttt cgacgtagag      600

gtttgtctcg cggagggaac ttgtcctaca ctggctgtag caatttcccc ttcagcctgg      660

tacagctggt gctctcagag attggtggaa gaaaggtata gctggactag ccagctgagt      720

cccgcggacc tcattccact tgaggtaccc accggggcgt caagcccaac tcagagggac      780

tggcaggaac aattggtagt tgggcataat gtgagttttg acagggctca tatccgcgaa      840

cagtatctta tccagggctc tagaatgcga ttccttgaca cgatgagcat gcacatggca      900

atcagcggac ttagttcctt tcagaggtca ttgtggattg cagccaagca gggaaagcat      960

aaggtccaac ccccgacaaa acaaggtcag aaatcccaga gaaaagcccg gcgaggcccc     1020

gccatcagtt cctgggattg gttggatatc agtagtgtga atagccttgc tgaggtgcat     1080

cgcctgtatg tgggtggacc cccacttgag aaagagccta gggagctctt cgtcaaaggc     1140

accatgaagg atattagaga gaattttcaa gatctcatgc aatactgcgc acaagacgta     1200

tgggcaacgc atgaggtctt tcaacagcaa ctccccctct ttttggaacg atgtccacat     1260

cccgtcactc ttgctgggat gttggaaatg ggtgtaagtt atttgccagt caatcaaaat     1320

tgggagagat acttggctga agcgcagggt acatatgagg aacttcagcg agaaatgaaa     1380

aaaagtctta tggatttggc caatgacgcc tgccagctgc tttccggtga gcggtacaaa     1440

gaagatccat ggctttggga tctcgaatgg gatttgcagg aatttaaaca gaaaaaggcc     1500

aagaaggtca agaaagagcc agctacagcc tcaaagctcc ctatagaggg agcgggagca     1560

ccgggtgatc cgatggatca agaggatttg ggaccttgct ccgaagagga ggaattccaa     1620

caagatgtaa tggcaagggc ctgcctgcaa aagctcaaag ggacaacaga actcttgccc     1680

aagaggcctc aacatctgcc cggccatcca ggttggtatc gcaaactctg tccaaggctg     1740

gacgatcccg cctggacccc ggggccctcc cttctgagtc tgcagatgag agtgacacct     1800

aagctgatgg cacttacttg ggatgggttc cctcttcact attcagagag acacgggtgg     1860

ggatatcttg tcccaggtcg aagggacaat ctggcgaagc ttcccacagg aactaccttg     1920

gagagtgcgg gcgtagtatg tccttatcga gccatagaaa gtctgtatag aaagcattgc     1980

cttgaacaag gcaaacaaca actcatgcct caggaagccg gcctcgctga agaatttctt     2040

cttactgata actctgctat ctggcaaaca gtggaggaac tggattacct cgaagtcgag     2100

gccgaagcga agatggaaaa tttgcgggcg gcggtcccag gtcagcccct tgctttgaca     2160

gcacgggggg gccctaagga tacccagccc agctatcatc acgggaacgg tccatataat     2220

gatgttgata tacctggttg ttggtttttt aaacttcctc ataaagatgg caattcatgt     2280

aacgttggat ccccattcgc aaaggacttc ctccccaaaa tggaggatgg gacgttgcaa     2340

gcaggtcccg gtggagcttc tgggccgcga gccctggaaa taaataagat gattagcttc     2400

tggaggaatg cacacaagcg catttcttca cagatggtag tgtggctgcc tcggagtgct     2460

ttgcccaggg ctgtgatcag acaccccgat tatgatgaag agggactgta cggggcaata     2520

ttgccccagg tggttacggc tggtactatt acccgccggg cagttgagcc gacctggctg     2580

acagcatcta atgccaggcc tgatcgcgtg ggttctgaac ttaaagcaat ggtccaagct     2640

ccgcctggat acacgcttgt cggcgcggac gtggactccc aggaactttg gatagcggct     2700

gtccttggcg atgcacattt tgcagggatg cacgggtgca cggcttttgg ctggatgaca     2760

cttcagggga ggaaatcaag ggggaccgac ctgcactcca agaccgcgac aacggtagga     2820

atctcaaggg aacacgctaa aattttcaat tatgggagaa tatatggtgc cggtcaaccg     2880

ttcgctgagc gccttctgat gcagtttaac cataggctga cacagcagga ggcagcggag     2940

aaggcgcagc agatgtacgc cgcaactaag ggtctcagat ggtatcgcct ctcagacgag     3000

ggcgagtggc ttgtccggga attgaacctc ccggtcgatc ggacggaagg tggttggatt     3060

agtcttcagg atctcagaaa ggtgcagcgg gaaacagcac gcaagtctca gtggaagaaa     3120

tgggaggtgg tcgccgagcg ggcatggaag ggtggaacag aatccgagat gtttaacaag     3180

ctggagagca tagcaactag tgacatccct aggacaccgg tcttgggatg ttgcattagc     3240

cgggcactcg agccatctgc cgtacaggaa gaattcatga cgtcacgggt caactgggtt     3300

gtccagtctt cagccgtcga ttatctgcat ttgatgctgg tcgcgatgaa gtggctcttc     3360

gaagagtttg ctatagatgg ccgattttgc atctctattc acgatgaggt gcgctacctg     3420

gtaagggaag aagaccgata ccgagccgcc ctcgcccttc agataacaaa tctgcttacc     3480

aggtgtatgt ttgcatacaa gctggggttg aacgaccttc cccagtccgt cgctttcttt     3540

tcagctgttg atatagatcg ctgcctgaga aaagaggtta cgatggactg caaaacgccc     3600

tcaaacccca ctggtatgga gcgcagatat ggcatccccc aaggagaagc cctcgacata     3660

taccagataa ttgagctcac gaagggcagc ctggagaaga gatcccaacc tggcccatag     3720


