                         SEQUENCE LISTING

<110>  EXELIXIS, INC.
 
<120>  ANTI-ROR ANTIBODY CONSTRUCTS

<130>  14529-001-228

<140>  
<141>  

<150>  US 62/659,635
<151>  2018-04-18

<160>  540   

<170>  PatentIn version 3.5

<210>  1
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent monospecific construct CHAIN 1, VL

<400>  1

Val Glu Ile Lys Arg Thr Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
1               5                   10                  15      


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            20                  25                  30          


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        35                  40                  45              


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    50                  55                  60                  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
65                  70                  75                  80  


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                85                  90                  95      


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp 
            100                 105                 110         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent monospecific construct CHAIN 2, VH

<400>  2

Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Leu 
1               5                   10                  15      


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
            20                  25                  30          


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        35                  40                  45              


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    50                  55                  60                  


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
65                  70                  75                  80  


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                85                  90                  95      


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105                 110         


<210>  3
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent, bispecific construct CHAIN 1, VL

<400>  3

Val Glu Ile Lys Arg Thr Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
1               5                   10                  15      


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            20                  25                  30          


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        35                  40                  45              


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    50                  55                  60                  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
65                  70                  75                  80  


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                85                  90                  95      


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp 
            100                 105                 110         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent, bispecific construct CHAIN 2, VH

<400>  4

Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Leu 
1               5                   10                  15      


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
            20                  25                  30          


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        35                  40                  45              


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    50                  55                  60                  


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
65                  70                  75                  80  


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                85                  90                  95      


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105                 110         


<210>  5
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent, bispecific construct CHAIN 3, VL

<400>  5

Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
1               5                   10                  15      


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
            20                  25                  30          


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
        35                  40                  45              


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
    50                  55                  60                  


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
65                  70                  75                  80  


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                85                  90                  95      


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp 
            100                 105                 110         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
225                 230                 235                 240 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210>  6
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example 1, bivalent, bispecific construct CHAIN 4, VH

<400>  6

Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
1               5                   10                  15      


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
            20                  25                  30          


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        35                  40                  45              


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    50                  55                  60                  


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
65                  70                  75                  80  


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                85                  90                  95      


Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
            100                 105                 


<210>  7
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc Fragment of Human IgG1

<400>  7

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            100                 105 


<210>  8
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 chain 1

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  9
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 chain 2

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Thr Pro Tyr Asp Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Glu Ile Ala Thr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Gly Glu Cys 
225         


<210>  10
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 chain 3 and BC28 bivalent chain 3

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  11
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 chain 4 and BC28 bivalent chain 4

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215         


<210>  12
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain A

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  13
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain B

<400>  13

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain D

<400>  14

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain E

<400>  15

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain F

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Thr Pro Tyr Asp Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Glu Ile Ala Thr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120         


<210>  17
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain G

<400>  17

Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Gly Glu Cys 
            100                 105 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain H

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain I

<400>  19

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  20
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain J

<400>  20

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain K

<400>  21

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain L

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  23
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Domain M

<400>  23

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Pro Lys Ser Cys 
            100                 


<210>  24
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 chain 1

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  25
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 chain 2

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Thr Pro Tyr Asp Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Glu Ile Ala Thr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  26
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain A

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  27
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain B

<400>  27

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain D

<400>  28

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain E

<400>  29

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain F

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Thr Pro Tyr Asp Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Glu Ile Ala Thr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120         


<210>  31
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 domain G

<400>  31

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  32
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC44 chain 1

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  33
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC44 Domain A

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  34
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC44 Domain B

<400>  34

Val Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  35
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC44 Domain D

<400>  35

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC44 Domain E

<400>  36

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  37
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 chain 3

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly Ser Glu Ile Val Leu 
    210                 215                 220                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
225                 230                 235                 240 


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr 
                245                 250                 255     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            260                 265                 270         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        275                 280                 285             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    290                 295                 300                 


Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln 
305                 310                 315                 320 


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
                325                 330                 335     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            340                 345                 350         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        355                 360                 365             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    370                 375                 380                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
385                 390                 395                 400 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                405                 410                 415     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            420                 425                 430         


Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        435                 440                 445             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    450                 455                 460                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
465                 470                 475                 480 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                485                 490                 495     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            500                 505                 510         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        515                 520                 525             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    530                 535                 540                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
545                 550                 555                 560 


Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                565                 570                 575     


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            580                 585                 590         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        595                 600                 605             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
    610                 615                 620                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
625                 630                 635                 640 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                645                 650                 655     


Leu Ser Pro Gly Lys 
            660     


<210>  38
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain R

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  39
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain S

<400>  39

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 linker

<400>  40

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain H

<400>  41

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain I

<400>  42

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  43
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain J

<400>  43

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28 1x2 domain K

<400>  44

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  45
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a chain 3

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Asp Ser Tyr Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Gly Ser Gly Ser Gly Ser Glu Ile Val Leu 
    210                 215                 220                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
225                 230                 235                 240 


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr 
                245                 250                 255     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            260                 265                 270         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        275                 280                 285             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    290                 295                 300                 


Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln 
305                 310                 315                 320 


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
                325                 330                 335     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            340                 345                 350         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        355                 360                 365             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    370                 375                 380                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
385                 390                 395                 400 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                405                 410                 415     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            420                 425                 430         


Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        435                 440                 445             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    450                 455                 460                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
465                 470                 475                 480 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                485                 490                 495     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            500                 505                 510         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        515                 520                 525             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    530                 535                 540                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
545                 550                 555                 560 


Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                565                 570                 575     


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            580                 585                 590         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        595                 600                 605             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
    610                 615                 620                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
625                 630                 635                 640 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                645                 650                 655     


Leu Ser Pro Gly Lys 
            660     


<210>  46
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain R

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Asp Ser Tyr Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  47
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain S

<400>  47

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a linker

<400>  48

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain H

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain I

<400>  50

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  51
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain J

<400>  51

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  52
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC28-1x1x1a domain K

<400>  52

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  53
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCTLA4-4.chain 2

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Pro Tyr Thr Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Tyr Thr Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCTLA4-4 domain F

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Pro Tyr Thr Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Tyr Thr Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser 
        115                 


<210>  55
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCTLA4-4 domain G

<400>  55

Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Gly Glu Cys 
            100                 105 


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  56

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1, BC5, BC6, BC13, BC14, BC24, BC25, BC28, BC30, and BC45, 
       Polypeptide 1 Domain Junction

<400>  57

Ile Lys Arg Thr Pro Arg Glu Pro 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC15 and BC44 Polypeptide 1 Domain Junction

<400>  58

Ile Lys Arg Thr Val Arg Glu Pro 
1               5               


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC16-Polypeptide 1 Domain Junction

<400>  59

Ile Lys Arg Thr Arg Glu Pro 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC17-Polypeptide 1 Domain Junction

<400>  60

Ile Lys Arg Thr Val Pro Arg Glu Pro 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC26-Polypeptide 1 Domain Junction

<400>  61

Ile Lys Arg Thr Val Ala Glu Pro 
1               5               


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC27-Polypeptide 1 Domain Junction

<400>  62

Ile Lys Arg Thr Val Ala Pro Arg Glu Pro 
1               5                   10  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1, BC5, BC6, BC15, BC16, BC17, BC26, BC27, BC28, BC30, BC44, 
       and BC45, Polypeptide 2 Domain Junction

<400>  63

Ser Ser Ala Ser Pro Arg Glu Pro 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC13-Polypeptide 2 Domain Junction

<400>  64

Ser Ser Ala Ser Thr Arg Glu Pro 
1               5               


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC14-Polypeptide 2 Domain Junction

<400>  65

Ser Ser Ala Ser Thr Pro Arg Glu Pro 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC24-Polypeptide 2 Domain Junction

<400>  66

Ser Ser Ala Ser Thr Lys Gly Glu Pro 
1               5                   


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC25-Polypeptide 2 Domain Junction

<400>  67

Ser Ser Ala Ser Thr Lys Gly Arg Glu Pro 
1               5                   10  


<210>  68
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VH

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120             


<210>  69
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VL

<400>  69

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  70
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VH-N30S VH, lower case denotes mutation

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120             


<210>  71
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VH-G65D VH, lower case denotes mutation

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120             


<210>  72
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VH-S68T VH, lower case denotes mutation

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120             


<210>  73
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34-89 VL-W57G VL, lower case denotes mutation

<400>  73

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  74
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phage display heavy chain


<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (50)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(67)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (100)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(114)
<223>  CDR sequences that were constant

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  75
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phage display light chain


<220>
<221>  MISC_FEATURE
<222>  (24)..(32)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (89)..(90)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (91)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(98)
<223>  CDR sequences that were constant

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  76
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-Body Domain A/H Scaffold


<220>
<221>  MISC_FEATURE
<222>  (24)..(32)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (89)..(90)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (91)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(98)
<223>  CDR sequences that were constant

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  77
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-Body Domain F/L Scaffold


<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (50)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(67)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (100)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(114)
<223>  CDR sequences that were constant

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125         


<210>  78
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 1 Scaffold


<220>
<221>  MISC_FEATURE
<222>  (24)..(32)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (89)..(90)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (91)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(98)
<223>  CDR sequences that were constant

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  79
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 2 Scaffold


<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (50)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(67)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (100)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(114)
<223>  CDR sequences that were constant

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Gly Glu Cys 
225                 230         


<210>  80
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 3 Scaffold


<220>
<221>  MISC_FEATURE
<222>  (24)..(32)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (89)..(90)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (91)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(98)
<223>  CDR sequences that were constant

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  81
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 4 Scaffold


<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (50)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(67)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (100)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(114)
<223>  CDR sequences that were constant

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  82
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 3 1(A)x2(B-A) SP34-89 Scaffold


<220>
<221>  MISC_FEATURE
<222>  (24)..(32)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR sequences that were constant

<220>
<221>  MISC_FEATURE
<222>  (89)..(90)
<223>  CDR sequences that were constant

<220>
<221>  misc_feature
<222>  (91)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(98)
<223>  CDR sequences that were constant

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
                565                 570                 575     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC1 Chain 3 1(A)x2(B-A) SP34-89 S-H Junction

<400>  83

Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
1               5                   10  


<210>  84
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 1 BC1 1x1

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  85
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 2 BC1 1x1

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Pro Ser Asp Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220             


<210>  86
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 3 BC1 1x1

<400>  86

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  87
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 4 BC1 1x1

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  88
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 3 BC1 1x2

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
                565                 570                 575     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  89
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 1 BC1 1x1

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  90
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 2 BC1 1x1

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Tyr Pro Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr Ile Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Asp Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu 
    210                 215                 220                 


Cys 
225 


<210>  91
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 3 BC1 1x1

<400>  91

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  92
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 4 BC1 1x1

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  93
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 3 BC1 1x2

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
                565                 570                 575     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  94
<211>  937
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ROR1 (UniProt accession #Q01973)

<400>  94

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  95
<211>  943
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ROR2 (UniProt accession #Q01974)

<400>  95

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  96
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 1

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  97
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 2 or Chain 5

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Tyr Pro Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr Ile Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Asp Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu 
    210                 215                 220                 


Cys 
225 


<210>  98
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 3

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                565                 570                 575     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  99
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Chain 4

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  100
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain A

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  101
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain B

<400>  101

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain D

<400>  102

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain E

<400>  103

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  104
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain F or Domain T

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Tyr Pro Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr Ile Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser 
        115                 120 


<210>  105
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain G or Domain U

<400>  105

Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Gly Glu Cys 
            100                 105 


<210>  106
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain R

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  107
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain S

<400>  107

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  108
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain H

<400>  108

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
            100                 105                 110         


Val 
    


<210>  109
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain I

<400>  109

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 


<210>  110
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain J

<400>  110

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain K

<400>  111

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  112
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain L

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125         


<210>  113
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-27 Domain M

<400>  113

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                85                  90                  95      


Glu Pro Pro Lys Ser Cys 
            100         


<210>  114
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 1

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  115
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 2 or Chain 5

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Pro Ser Asp Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  116
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 3

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                565                 570                 575     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  117
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Chain 4

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  118
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain A

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  119
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain B

<400>  119

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  120
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain D

<400>  120

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain E

<400>  121

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  122
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain F or Domain T

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Pro Ser Asp Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser 
        115                 


<210>  123
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain G or Domain U

<400>  123

Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Gly Glu Cys 
            100                 105 


<210>  124
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain R

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  125
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain S

<400>  125

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  126
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain H

<400>  126

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
            100                 105                 110         


Val 
    


<210>  127
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain I

<400>  127

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 


<210>  128
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain J

<400>  128

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain K

<400>  129

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  130
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain L

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125         


<210>  131
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 Domain M

<400>  131

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                85                  90                  95      


Glu Pro Pro Lys Ser Cys 
            100         


<210>  132
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Chain 1

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  133
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Chain 2 or Chain 5

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Pro Ser Glu Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  134
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Chain 3

<400>  134

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Thr Ala Ser Ser Gly Gly Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    290                 295                 300                 


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
                325                 330                 335     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            340                 345                 350         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        355                 360                 365             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    370                 375                 380                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                405                 410                 415     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            420                 425                 430         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                565                 570                 575     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  135
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Chain 4

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Pro Lys Ser Cys 
225                 


<210>  136
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain A

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  137
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain B

<400>  137

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  138
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain D

<400>  138

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  139
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain E

<400>  139

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  140
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain F or Domain T

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Pro Ser Glu Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser 
        115                 


<210>  141
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain G or Domain U

<400>  141

Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Gly Glu Cys 
            100                 105 


<210>  142
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain R

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  143
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain S

<400>  143

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Lys Ser Cys 
            100                 105 


<210>  144
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain H

<400>  144

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Thr 
            100                 105                 110         


Val 
    


<210>  145
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain I

<400>  145

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 


<210>  146
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain J

<400>  146

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  147
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain K

<400>  147

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  148
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain L

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125         


<210>  149
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I2A-10 D54E Y55Q Domain M

<400>  149

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                85                  90                  95      


Glu Pro Pro Lys Ser Cys 
            100         


<210>  150
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary signal sequence for I2A-27, I2A-10 and I2A-10 D54E 
       Y55Q, e.g., Chain 1

<400>  150

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser 
            


<210>  151
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary signal sequence for I2A-27, I2A-10 and I2A-10 D54E Y55Q
       , e.g., Chain 2, 3, 4 or 5

<400>  151

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  152
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary signal sequence for I2A-27, I2A-10 and I2A-10 D54E 
       Y55Q, e.g., Chain 3

<400>  152

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Ser 
            20              


<210>  153
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-1

<400>  153

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-1

<400>  154

Ala Ile Tyr Pro Glu Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-1

<400>  155

Asp Tyr Lys Tyr Val Gly Ala Leu 
1               5               


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-1

<400>  156

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-1

<400>  157

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-1

<400>  158

Tyr Tyr Tyr Phe Pro Gly 
1               5       


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-2

<400>  159

Phe Ser Tyr Tyr Gly Ile 
1               5       


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-2

<400>  160

Phe Ile Tyr Ser Arg Gly Gly Tyr Thr Ile 
1               5                   10  


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-2

<400>  161

Tyr Ile Gly Ala Gly Leu 
1               5       


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-2

<400>  162

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-2

<400>  163

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-2

<400>  164

Tyr Tyr Trp Asp Pro Ile 
1               5       


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-3

<400>  165

Phe Thr Ser Tyr Glu Ile 
1               5       


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-3

<400>  166

His Ile Asp Pro Tyr Gly Gly Tyr Thr Gln 
1               5                   10  


<210>  167
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-3

<400>  167

Arg Gly Val Ala Val Phe 
1               5       


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-3

<400>  168

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-3

<400>  169

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  170
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-3

<400>  170

Trp Ala Tyr Ala Pro Val 
1               5       


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-4

<400>  171

Phe Tyr Ser Tyr Asp Ile 
1               5       


<210>  172
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-4

<400>  172

Tyr Ile Ser Pro Tyr Trp Gly Ile Thr Thr 
1               5                   10  


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-4

<400>  173

Tyr Ile Gly Ser Ser Tyr Trp Asp Ala Leu 
1               5                   10  


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-4

<400>  174

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-4

<400>  175

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-4

<400>  176

Ser Asp Ser Ser Leu Val 
1               5       


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-5

<400>  177

Phe Ser Ser Tyr Gly Ile 
1               5       


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-5

<400>  178

Trp Ile Ser Pro Thr Gly Ser Ile Thr Ile 
1               5                   10  


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-5

<400>  179

Ser Tyr Met Ile Tyr Gly Gly Leu 
1               5               


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-5

<400>  180

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-5

<400>  181

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  182
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-5

<400>  182

Arg Val Ser Ser Pro Trp 
1               5       


<210>  183
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-6

<400>  183

Phe Ser Leu Tyr Ala Ile 
1               5       


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-6

<400>  184

Glu Ile Asp Ser Trp Leu Gly Tyr Thr Tyr 
1               5                   10  


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-6

<400>  185

Arg Pro Val Thr Glu Val Tyr Tyr Ser Ala Leu 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-6

<400>  186

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-6

<400>  187

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  188
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-6

<400>  188

Tyr Asp Arg Ser Leu His 
1               5       


<210>  189
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-7

<400>  189

Phe Ser Arg Tyr Tyr Ile 
1               5       


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-7

<400>  190

Asp Ile Asp Ser Tyr Gly Gly Phe Thr Tyr 
1               5                   10  


<210>  191
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-7

<400>  191

Ala His Arg Phe Leu Gln Gly Gly Tyr Val Leu 
1               5                   10      


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-7

<400>  192

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-7

<400>  193

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-7

<400>  194

Tyr Ser Trp Gly Leu Trp 
1               5       


<210>  195
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-8

<400>  195

Phe Tyr Gly Tyr Tyr Ile 
1               5       


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-8

<400>  196

Gly Ile Arg Pro Gly Gly Thr Tyr Thr Tyr 
1               5                   10  


<210>  197
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-8

<400>  197

Tyr Arg Tyr Pro Ala Phe 
1               5       


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-8

<400>  198

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-8

<400>  199

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  200
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-8

<400>  200

Arg Arg Gln His Leu Trp 
1               5       


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-9

<400>  201

Phe Ser Ser Tyr Thr Ile 
1               5       


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-9

<400>  202

Ala Ile Asp Ser Gly Trp Ser Tyr Thr Asp 
1               5                   10  


<210>  203
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-9

<400>  203

Ala Tyr Gly Gly Val Met 
1               5       


<210>  204
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-9

<400>  204

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-9

<400>  205

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-9

<400>  206

Tyr Trp Trp Pro Gly 
1               5   


<210>  207
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-10

<400>  207

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  208
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-10

<400>  208

Gly Ile Tyr Pro Ser Asp Gly Tyr Thr Ser 
1               5                   10  


<210>  209
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-10

<400>  209

Tyr Tyr Val Ser Gly Met 
1               5       


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-10

<400>  210

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-10

<400>  211

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  212
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-10

<400>  212

Tyr Tyr Tyr Tyr Pro Gly 
1               5       


<210>  213
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-10 D54E Y55Q

<400>  213

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-10 D54E Y55Q

<400>  214

Gly Ile Tyr Pro Ser Glu Gly Tyr Thr Ser 
1               5                   10  


<210>  215
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-10 D54E Y55Q

<400>  215

Tyr Tyr Val Ser Gly Met 
1               5       


<210>  216
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-10 D54E Y55Q

<400>  216

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-10 D54E Y55Q

<400>  217

Ser Ala Ser Ser Leu Gln Ser 
1               5           


<210>  218
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-10 D54E Y55Q

<400>  218

Tyr Tyr Tyr Tyr Pro Gly 
1               5       


<210>  219
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-11

<400>  219

Phe Ser Ser Tyr Val Ile 
1               5       


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-11

<400>  220

Ala Ile Tyr Pro Tyr Thr Ser Ser Thr Gln 
1               5                   10  


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-11

<400>  221

Ser Tyr Gly Thr Gly Gly Phe 
1               5           


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-11

<400>  222

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-11

<400>  223

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-11

<400>  224

Trp Tyr Ser Tyr Pro Leu 
1               5       


<210>  225
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-12

<400>  225

Phe Thr Thr Tyr Tyr Ile 
1               5       


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-12

<400>  226

Tyr Ile Ser Pro Glu Asp Gly Tyr Thr Ser 
1               5                   10  


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-12

<400>  227

Ala Tyr Tyr Ser Ala Val Met 
1               5           


<210>  228
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-12

<400>  228

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-12

<400>  229

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  230
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-12

<400>  230

Ser Trp Ser Pro Ala Thr 
1               5       


<210>  231
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-13

<400>  231

Phe Ser Tyr Tyr Phe Ile 
1               5       


<210>  232
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-13

<400>  232

Val Ile Tyr Pro Asp Gly Gly Tyr Thr Leu 
1               5                   10  


<210>  233
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-13

<400>  233

Ile Tyr Tyr Pro Ser Gly Ala Met 
1               5               


<210>  234
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-13

<400>  234

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-13

<400>  235

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  236
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-13

<400>  236

Thr Tyr Trp Tyr Pro Gly 
1               5       


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-14

<400>  237

Phe Asp Ser Tyr Val Ile 
1               5       


<210>  238
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-14

<400>  238

Tyr Ile Phe Ser Phe Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  239
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-14

<400>  239

Ser Pro Tyr Gly Thr Phe Ala Leu 
1               5               


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-14

<400>  240

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-14

<400>  241

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  242
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-14

<400>  242

Tyr Tyr Tyr Thr Pro Gly 
1               5       


<210>  243
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-15

<400>  243

Phe Trp Gly Tyr Val Ile 
1               5       


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-15

<400>  244

Ala Ile Asp Ser Trp Asp Gly Asp Thr Asp 
1               5                   10  


<210>  245
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-15

<400>  245

Ser Phe Tyr Tyr Ile Tyr Val Met 
1               5               


<210>  246
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-15

<400>  246

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-15

<400>  247

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  248
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-15

<400>  248

Leu Tyr Ser Thr Leu Val 
1               5       


<210>  249
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-16

<400>  249

Phe Ser Gly Tyr Phe Ile 
1               5       


<210>  250
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-16

<400>  250

Ala Ile Phe Pro Tyr Arg Gly Gly Thr Ser 
1               5                   10  


<210>  251
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-16

<400>  251

Gly Gly Val Ser Pro Gly Gly Phe 
1               5               


<210>  252
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-16

<400>  252

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-16

<400>  253

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  254
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-16

<400>  254

Tyr Tyr Leu Tyr Pro Gly 
1               5       


<210>  255
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-17

<400>  255

Phe Glu Ser Tyr Asp Ile 
1               5       


<210>  256
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-17

<400>  256

Ala Ile Phe Ser Tyr Gly Gly Tyr Thr Thr 
1               5                   10  


<210>  257
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-17

<400>  257

Gly Ser Tyr Gly Asp Gly Arg Gly Met 
1               5                   


<210>  258
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-17

<400>  258

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-17

<400>  259

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  260
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-17

<400>  260

Tyr Tyr Tyr Trp Pro Gly 
1               5       


<210>  261
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-18

<400>  261

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  262
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-18

<400>  262

Ala Ile His Pro Ala Phe Ser Phe Thr Tyr 
1               5                   10  


<210>  263
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-18

<400>  263

Pro Arg Leu Ser Ser Ala Val Val Leu 
1               5                   


<210>  264
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-18

<400>  264

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  265
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-18

<400>  265

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  266
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-19

<400>  266

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  267
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-19

<400>  267

Trp Ile Tyr Pro Ser Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  268
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-19

<400>  268

Glu Met Asp Arg Val Gly Tyr Ser Gly Met 
1               5                   10  


<210>  269
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-19

<400>  269

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-19

<400>  270

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  271
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-19

<400>  271

Tyr Arg Thr Pro Leu Gly 
1               5       


<210>  272
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-20

<400>  272

Phe Ser Asp Tyr Gly Ile 
1               5       


<210>  273
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-20

<400>  273

Glu Ile Asp Ser Trp Leu Gly Tyr Thr Tyr 
1               5                   10  


<210>  274
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-20

<400>  274

Ser Pro Tyr His Tyr Leu Tyr Tyr Gly Leu 
1               5                   10  


<210>  275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-20

<400>  275

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-20

<400>  276

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  277
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-20

<400>  277

Leu Ser Ser Ser Leu Gly 
1               5       


<210>  278
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-21

<400>  278

Phe Ser Gly Tyr Phe Ile 
1               5       


<210>  279
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-21

<400>  279

Gly Ile Ser Pro Trp Ala Gly Tyr Thr Ser 
1               5                   10  


<210>  280
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-21

<400>  280

Gly Gly Gly Arg Ala Phe 
1               5       


<210>  281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-21

<400>  281

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  282
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-21

<400>  282

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  283
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-21

<400>  283

Tyr Tyr Trp Tyr Pro Gly 
1               5       


<210>  284
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-22

<400>  284

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  285
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-22

<400>  285

Ala Ile Tyr Pro Ser Gly Trp Tyr Thr Ser 
1               5                   10  


<210>  286
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-22

<400>  286

Val Gln Ala Gly Val Phe 
1               5       


<210>  287
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-22

<400>  287

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  288
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-22

<400>  288

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  289
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-22

<400>  289

Tyr Tyr Tyr Tyr Pro Gly 
1               5       


<210>  290
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-23

<400>  290

Phe Asp Asp Tyr Phe Ile 
1               5       


<210>  291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-23

<400>  291

Ala Ile Ser Ser Glu Gly Gly Tyr Thr Asp 
1               5                   10  


<210>  292
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-23

<400>  292

Ala Tyr Arg Gly Val Phe 
1               5       


<210>  293
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-23

<400>  293

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  294
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-23

<400>  294

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  295
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-23

<400>  295

Tyr Tyr Tyr Phe Pro Gly 
1               5       


<210>  296
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-24

<400>  296

Phe Ser Thr Tyr Gly Ile 
1               5       


<210>  297
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-24

<400>  297

Ala Ile Tyr Pro Gly Thr Ser Tyr Thr Gly 
1               5                   10  


<210>  298
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-24

<400>  298

Glu Tyr Phe Met Gly Met 
1               5       


<210>  299
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-24

<400>  299

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  300
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-24

<400>  300

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  301
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-24

<400>  301

Tyr Tyr Tyr Trp Pro Gly 
1               5       


<210>  302
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-25

<400>  302

Phe Tyr Gly Tyr Thr Ile 
1               5       


<210>  303
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-25

<400>  303

Ala Ile Tyr Pro Tyr Thr Asp Ser Thr Arg 
1               5                   10  


<210>  304
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-25

<400>  304

Asp Tyr Arg Arg Ala Leu 
1               5       


<210>  305
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-25

<400>  305

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-25

<400>  306

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  307
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-25

<400>  307

Tyr Thr Asp Phe Pro Trp 
1               5       


<210>  308
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-26

<400>  308

Phe Gln Ser Tyr Asp Ile 
1               5       


<210>  309
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-26

<400>  309

Ala Ile Asp Pro Thr Gly Arg Ser Thr Ala 
1               5                   10  


<210>  310
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-26

<400>  310

Asp Tyr Gly Val Phe 
1               5   


<210>  311
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-26

<400>  311

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-26

<400>  312

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  313
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-26

<400>  313

Phe Tyr Arg Ser Pro Ala 
1               5       


<210>  314
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-27

<400>  314

Phe Lys Gly Tyr Tyr Ile 
1               5       


<210>  315
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-27

<400>  315

Ala Ile Tyr Pro Tyr Gly Gly Ser Thr Asp 
1               5                   10  


<210>  316
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-27

<400>  316

Val Tyr Ile Tyr Gly Val Phe 
1               5           


<210>  317
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-27

<400>  317

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  318
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-27

<400>  318

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  319
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-27

<400>  319

Tyr Tyr Ser Ser Pro Arg 
1               5       


<210>  320
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-28

<400>  320

Phe Ser Ser Tyr Trp Ile 
1               5       


<210>  321
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-28

<400>  321

Trp Ile Tyr Pro Gly Thr Arg Tyr Thr Glu 
1               5                   10  


<210>  322
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-28

<400>  322

Asp Tyr Val Trp Pro Tyr Gly Phe 
1               5               


<210>  323
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-28

<400>  323

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  324
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-28

<400>  324

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  325
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-28

<400>  325

Ala Ser Trp Ser Pro Val 
1               5       


<210>  326
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-29

<400>  326

Phe Ser Ser Tyr Trp Ile 
1               5       


<210>  327
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-29

<400>  327

Trp Ile Tyr Ser Ser Gly Gly Tyr Thr Phe 
1               5                   10  


<210>  328
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-29

<400>  328

Glu Tyr Phe Leu Tyr Thr Gly Phe 
1               5               


<210>  329
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-29

<400>  329

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  330
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-29

<400>  330

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  331
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-29

<400>  331

Tyr Ser Ser Gly Pro Val 
1               5       


<210>  332
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-30

<400>  332

Phe Asp Ser Tyr Phe Ile 
1               5       


<210>  333
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-30

<400>  333

Tyr Ile Tyr Ser Trp Gly Ser Tyr Thr His 
1               5                   10  


<210>  334
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-30

<400>  334

Gly His Arg Arg Tyr Phe Ala Leu 
1               5               


<210>  335
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-30

<400>  335

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  336
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-30

<400>  336

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  337
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-30

<400>  337

Val Tyr Phe Thr Pro Gly 
1               5       


<210>  338
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-31

<400>  338

Phe Ser Ser Tyr Trp Ile 
1               5       


<210>  339
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-31

<400>  339

Phe Ile Gly Pro Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  340
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-31

<400>  340

Glu Thr Asp Ser Tyr Thr Gly Phe 
1               5               


<210>  341
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-31

<400>  341

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  342
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-31

<400>  342

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  343
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-31

<400>  343

Tyr Tyr Ser Trp Leu Gly 
1               5       


<210>  344
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-32

<400>  344

Phe Gln Ser Tyr Val Ile 
1               5       


<210>  345
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-32

<400>  345

Ala Ile Tyr Pro Tyr Ser Ser Ser Thr Ile 
1               5                   10  


<210>  346
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-32

<400>  346

Ser Trp Ser Val Tyr Leu Gly Met 
1               5               


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-32

<400>  347

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  348
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-32

<400>  348

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  349
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-32

<400>  349

Ser Tyr Asp Ser Pro Arg 
1               5       


<210>  350
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-33

<400>  350

Phe Asp Asp Tyr Tyr Ile 
1               5       


<210>  351
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-33

<400>  351

Trp Ile Asp Ser Tyr Gly Gly Tyr Thr Ser 
1               5                   10  


<210>  352
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-33

<400>  352

Ser Ser Tyr Tyr Tyr Pro Gly Gly Phe 
1               5                   


<210>  353
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-33

<400>  353

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  354
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-33

<400>  354

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  355
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-33

<400>  355

Trp Asp Ser Thr Leu Tyr 
1               5       


<210>  356
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-34

<400>  356

Phe Ser Trp Tyr Val Ile 
1               5       


<210>  357
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-34

<400>  357

Tyr Ile Ala Pro Tyr Thr Gly Ser Thr Tyr 
1               5                   10  


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-34

<400>  358

Ala Phe Phe Gly Ile Arg Leu Gly Leu 
1               5                   


<210>  359
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-34

<400>  359

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  360
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-34

<400>  360

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  361
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-34

<400>  361

Ala Ile Ser Ser Pro Tyr 
1               5       


<210>  362
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-35

<400>  362

Phe Ser Ala Tyr Asp Ile 
1               5       


<210>  363
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-35

<400>  363

Trp Ile Asp Pro Tyr Gly Gly Asp Thr Asp 
1               5                   10  


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-35

<400>  364

Ser Pro Ser Tyr Met Gln Tyr Gly Gly Leu 
1               5                   10  


<210>  365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-35

<400>  365

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  366
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-35

<400>  366

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  367
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-35

<400>  367

Tyr Tyr Ser Ser Leu Leu 
1               5       


<210>  368
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-36

<400>  368

Phe Ser Gln Tyr Trp Ile 
1               5       


<210>  369
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-36

<400>  369

Ala Ile Tyr Ser Ser Thr Lys Tyr Thr Ile 
1               5                   10  


<210>  370
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-36

<400>  370

Glu Ser Met Tyr Phe Tyr Ser Tyr Gly Leu 
1               5                   10  


<210>  371
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-36

<400>  371

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  372
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-36

<400>  372

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  373
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-36

<400>  373

Leu Pro Ser Thr Pro Leu 
1               5       


<210>  374
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-37

<400>  374

Phe Ser Trp Tyr Gly Ile 
1               5       


<210>  375
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-37

<400>  375

Tyr Ile Asp Ser Tyr Thr Ser Ser Thr Tyr 
1               5                   10  


<210>  376
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-37

<400>  376

Ser His Phe Gly His Tyr Asp Tyr Val Met 
1               5                   10  


<210>  377
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-37

<400>  377

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  378
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-37

<400>  378

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  379
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2A-37

<400>  379

Ala Tyr Asp Gln Leu Tyr 
1               5       


<210>  380
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2A-38

<400>  380

Phe Asp Trp Tyr Arg Ile 
1               5       


<210>  381
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2A-38

<400>  381

Trp Ile Asp Ser Tyr Gly Ser Trp Thr Gly 
1               5                   10  


<210>  382
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2A-38

<400>  382

Ser Tyr Phe Gly Pro Tyr Gly Tyr Val Leu 
1               5                   10  


<210>  383
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2A-38

<400>  383

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  384
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2A-38

<400>  384

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  385
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-1

<400>  385

Phe Thr Ser Tyr Gly Ile 
1               5       


<210>  386
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-1

<400>  386

Ala Ile Tyr Pro His Ser Gly Phe Thr Ser 
1               5                   10  


<210>  387
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-1

<400>  387

Thr Ser Tyr Arg Gly Phe 
1               5       


<210>  388
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-1

<400>  388

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  389
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-1

<400>  389

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  390
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-1

<400>  390

Tyr Tyr Trp Tyr Pro Gly 
1               5       


<210>  391
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-2

<400>  391

Phe Ser Asp Tyr Phe Ile 
1               5       


<210>  392
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-2

<400>  392

Gly Ile Tyr Pro Tyr Ser Gly Tyr Thr Lys 
1               5                   10  


<210>  393
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-2

<400>  393

Asp His Ser Pro Val Leu 
1               5       


<210>  394
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-2

<400>  394

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  395
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-2

<400>  395

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  396
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-2

<400>  396

Trp Tyr Tyr Trp Pro Gly 
1               5       


<210>  397
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-3

<400>  397

Phe Ser His Tyr Trp Ile 
1               5       


<210>  398
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-3

<400>  398

Leu Ile Ala Pro Gly Gly Asp Tyr Thr Ser 
1               5                   10  


<210>  399
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-3

<400>  399

Ser Gly Leu Pro Gly Phe 
1               5       


<210>  400
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-3

<400>  400

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-3

<400>  401

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  402
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-3

<400>  402

Tyr Lys Ser Ser Pro Leu 
1               5       


<210>  403
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-4

<400>  403

Phe Trp Ser Tyr Phe Ile 
1               5       


<210>  404
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-4

<400>  404

Tyr Ile His Pro Ser Ser Ser Tyr Thr Asp 
1               5                   10  


<210>  405
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-4

<400>  405

Thr Ser Arg Asp Gly Ala Met 
1               5           


<210>  406
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-4

<400>  406

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-4

<400>  407

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  408
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-4

<400>  408

Trp Tyr Ser Pro Pro Glu 
1               5       


<210>  409
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-5

<400>  409

Phe Ser Ser Tyr Asp Ile 
1               5       


<210>  410
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-5

<400>  410

Trp Ile Tyr Pro Tyr Trp Gly Tyr Thr Ile 
1               5                   10  


<210>  411
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-5

<400>  411

Gly Thr Tyr Ala Pro Ala Leu 
1               5           


<210>  412
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-5

<400>  412

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  413
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-5

<400>  413

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  414
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-5

<400>  414

Phe Tyr Ser Tyr Leu Ser 
1               5       


<210>  415
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-6

<400>  415

Phe Ser Trp Tyr Phe Ile 
1               5       


<210>  416
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-6

<400>  416

Arg Ile Tyr Ser Thr Gly Gly Tyr Thr Glu 
1               5                   10  


<210>  417
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-6

<400>  417

Ser Ala Phe Phe Gly Ala Leu 
1               5           


<210>  418
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-6

<400>  418

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  419
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-6

<400>  419

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  420
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-6

<400>  420

Tyr Pro Ser Gly Pro Glu 
1               5       


<210>  421
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-7

<400>  421

Phe Asp Ser Tyr Tyr Ile 
1               5       


<210>  422
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-7

<400>  422

Trp Ile Asp Pro Tyr Gly Leu Asp Thr Lys 
1               5                   10  


<210>  423
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-7

<400>  423

Glu Pro Gly Asp Tyr Gly Met 
1               5           


<210>  424
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-7

<400>  424

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  425
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-7

<400>  425

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  426
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-7

<400>  426

Ala Tyr Gly Ser Leu Leu 
1               5       


<210>  427
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-8

<400>  427

Phe Ser Gly Tyr Phe Ile 
1               5       


<210>  428
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-8

<400>  428

Ala Ile Phe Pro Tyr Arg Gly Gly Thr Ser 
1               5                   10  


<210>  429
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-8

<400>  429

Gly Gly Val Ser Pro Gly Gly Phe 
1               5               


<210>  430
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-8

<400>  430

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  431
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-8

<400>  431

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  432
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-8

<400>  432

Tyr Tyr Leu Tyr Pro Gly 
1               5       


<210>  433
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-9

<400>  433

Phe Thr Asp Tyr Asp Ile 
1               5       


<210>  434
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-9

<400>  434

Arg Ile Trp Pro His Gly Ser Tyr Thr Phe 
1               5                   10  


<210>  435
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-9

<400>  435

Ser Leu Thr His Ser Tyr Gly Phe 
1               5               


<210>  436
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-9

<400>  436

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  437
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-9

<400>  437

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  438
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-9

<400>  438

Tyr Tyr Thr Trp Leu Ile 
1               5       


<210>  439
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-10

<400>  439

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  440
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-10

<400>  440

Thr Ile His Ser Tyr Phe Asp Gly Thr Ser 
1               5                   10  


<210>  441
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-10

<400>  441

Thr Arg Pro Thr Gly Gly Ala Phe 
1               5               


<210>  442
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-10

<400>  442

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  443
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-10

<400>  443

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  444
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-10

<400>  444

Ala Tyr Trp Ser Pro Ala 
1               5       


<210>  445
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-11

<400>  445

Phe Gly Ser Tyr Phe Ile 
1               5       


<210>  446
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-11

<400>  446

Ala Ile Phe Pro Ala Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  447
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-11

<400>  447

Tyr Gly Ser Met Gly Gly Ala Phe 
1               5               


<210>  448
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-11

<400>  448

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  449
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-11

<400>  449

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  450
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-11

<400>  450

Tyr Tyr Trp Phe Pro Gly 
1               5       


<210>  451
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-12

<400>  451

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  452
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-12

<400>  452

Ala Ile His Pro Ala Phe Ser Phe Thr Tyr 
1               5                   10  


<210>  453
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-12

<400>  453

Pro Arg Leu Ser Ser Ala Val Val Leu 
1               5                   


<210>  454
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-12

<400>  454

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  455
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-12

<400>  455

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  456
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-12

<400>  456

Gly Tyr Tyr Phe Pro Gly 
1               5       


<210>  457
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-13

<400>  457

Phe Ser Ser Tyr Gly Ile 
1               5       


<210>  458
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-13

<400>  458

Tyr Ile His Ser Gly Ile Gly Tyr Thr Ile 
1               5                   10  


<210>  459
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-13

<400>  459

Thr Ser Ser Thr Ser Thr Ser Val Met 
1               5                   


<210>  460
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-13

<400>  460

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  461
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-13

<400>  461

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  462
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-13

<400>  462

Thr Tyr Trp Ser Pro Gly 
1               5       


<210>  463
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-14

<400>  463

Phe Glu Ser Tyr Asp Ile 
1               5       


<210>  464
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-14

<400>  464

Ala Ile Phe Ser Tyr Gly Gly Tyr Thr Thr 
1               5                   10  


<210>  465
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-14

<400>  465

Gly Ser Tyr Gly Asp Gly Arg Gly Met 
1               5                   


<210>  466
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-14

<400>  466

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-14

<400>  467

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  468
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-14

<400>  468

Tyr Tyr Tyr Trp Pro Gly 
1               5       


<210>  469
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-15

<400>  469

Phe Ser Ser Tyr Phe Ile 
1               5       


<210>  470
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-15

<400>  470

Leu Ile Tyr Pro Asp Thr Asp Asp Thr Tyr 
1               5                   10  


<210>  471
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-15

<400>  471

Tyr Gly Tyr Leu Gly Val Gly Ala Phe 
1               5                   


<210>  472
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-15

<400>  472

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  473
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-15

<400>  473

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  474
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-15

<400>  474

Leu Tyr Trp Thr Pro Gly 
1               5       


<210>  475
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-16

<400>  475

Phe Ser Ser Tyr Trp Ile 
1               5       


<210>  476
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-16

<400>  476

Ala Ile His Pro Ser Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  477
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-16

<400>  477

Val Gly Leu Leu Val Thr Ser Val Met 
1               5                   


<210>  478
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-16

<400>  478

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  479
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-16

<400>  479

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  480
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-16

<400>  480

Tyr Tyr Tyr Phe Pro Gly 
1               5       


<210>  481
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-17

<400>  481

Phe Ser Asp Tyr Phe Ile 
1               5       


<210>  482
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-17

<400>  482

Tyr Ile Tyr Pro Ala Ser Gly Gly Thr Cys 
1               5                   10  


<210>  483
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-17

<400>  483

Gly Tyr Ile Pro His Met Ala Ala Leu 
1               5                   


<210>  484
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-17

<400>  484

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  485
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-17

<400>  485

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  486
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-17

<400>  486

Tyr Tyr Trp Trp Pro Gly 
1               5       


<210>  487
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-18

<400>  487

Phe Ala Gly Tyr Pro Ile 
1               5       


<210>  488
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-18

<400>  488

Ala Ile Asp Pro Asp Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  489
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-18

<400>  489

His Thr Gly Phe His Arg Tyr Arg Gly Met 
1               5                   10  


<210>  490
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-18

<400>  490

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  491
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-18

<400>  491

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  492
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-18

<400>  492

Tyr Tyr Trp Phe Pro Pro 
1               5       


<210>  493
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-19

<400>  493

Phe Thr Ser Tyr Asp Ile 
1               5       


<210>  494
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-19

<400>  494

Trp Ile Asp Pro Gly Leu Ser Tyr Thr Ser 
1               5                   10  


<210>  495
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-19

<400>  495

Ala Ser Ile Gly Gly Gly Val Pro Val Met 
1               5                   10  


<210>  496
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-19

<400>  496

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  497
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-19

<400>  497

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  498
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-19

<400>  498

Tyr Val Thr Gly Pro Tyr 
1               5       


<210>  499
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-20

<400>  499

Phe Ser Ser Tyr Tyr Ile 
1               5       


<210>  500
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-20

<400>  500

Ile Ile Ile Pro Tyr Ser Gly Tyr Thr Tyr 
1               5                   10  


<210>  501
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-20

<400>  501

Arg Gly Tyr Phe Ser Leu Gly Thr Ala Met 
1               5                   10  


<210>  502
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-20

<400>  502

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  503
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-20

<400>  503

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  504
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-20

<400>  504

Val Tyr Trp Trp Pro Gly 
1               5       


<210>  505
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-21

<400>  505

Phe Ser Ser Tyr Tyr Ile 
1               5       


<210>  506
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-21

<400>  506

Trp Ile Asp Pro Tyr Ile Ser Tyr Thr Tyr 
1               5                   10  


<210>  507
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-21

<400>  507

Asp Ser Glu Leu Val Ser Gly Tyr Ala Met 
1               5                   10  


<210>  508
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-21

<400>  508

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  509
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-21

<400>  509

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  510
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-21

<400>  510

Gly Asp Ser Ser Leu Val 
1               5       


<210>  511
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-22

<400>  511

Phe Ser Ser Tyr Ser Ile 
1               5       


<210>  512
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-22

<400>  512

Ala Ile Tyr Pro Tyr Trp Gly Thr Thr Glu 
1               5                   10  


<210>  513
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-22

<400>  513

Pro Ser Gly Val Thr Tyr Gly Tyr Ala Leu 
1               5                   10  


<210>  514
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-22

<400>  514

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  515
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-22

<400>  515

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  516
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-22

<400>  516

Tyr Tyr Tyr Ser Pro Trp 
1               5       


<210>  517
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-23

<400>  517

Phe Ser Ser Tyr Glu Ile 
1               5       


<210>  518
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-23

<400>  518

Ser Ile Tyr Pro Phe Ser Gly Asp Thr Tyr 
1               5                   10  


<210>  519
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-23

<400>  519

Pro Gly Arg Ala Ile Tyr Tyr Ala Val Met 
1               5                   10  


<210>  520
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-23

<400>  520

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  521
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-23

<400>  521

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  522
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-23

<400>  522

Ala Gly Ser His Leu Phe 
1               5       


<210>  523
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-24

<400>  523

Phe Ser Arg Tyr Tyr Ile 
1               5       


<210>  524
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-24

<400>  524

Asp Ile Asp Ser Tyr Gly Gly Phe Thr Tyr 
1               5                   10  


<210>  525
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-24

<400>  525

Ala His Arg Phe Leu Gln Gly Gly Tyr Val Leu 
1               5                   10      


<210>  526
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-24

<400>  526

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  527
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-24

<400>  527

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  528
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-24

<400>  528

Tyr Ser Trp Gly Leu Trp 
1               5       


<210>  529
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-25

<400>  529

Phe Ser Asp Tyr Tyr Ile 
1               5       


<210>  530
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-25

<400>  530

Tyr Ile Ala Pro Tyr Gly Gly Phe Thr Tyr 
1               5                   10  


<210>  531
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-25

<400>  531

Asp Ser Tyr Arg Arg Gly Tyr Val Ser Gly Phe 
1               5                   10      


<210>  532
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-25

<400>  532

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  533
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-25

<400>  533

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  534
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-25

<400>  534

Arg Tyr Ser Ser Pro Ser 
1               5       


<210>  535
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH of I2C-26

<400>  535

Phe Ser Asp Tyr Tyr Ile 
1               5       


<210>  536
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH of I2C-26

<400>  536

Asp Ile Asp Ser Tyr Gly Gly Phe Thr Tyr 
1               5                   10  


<210>  537
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH of I2C-26

<400>  537

Asp Pro His Phe Leu Asp Asp Val Tyr Val Leu 
1               5                   10      


<210>  538
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL of I2C-26

<400>  538

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  539
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL of I2C-26

<400>  539

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  540
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL of I2C-26

<400>  540

Tyr Ser Trp Gly Leu Trp 
1               5       


