                         SEQUENCE LISTING

<110>  UNIVERSITY OF MARYLAND, COLLEGE PARK
       Park, Chi-Hun
       V.L. Telugu, Bhanu P.
 
<120>  GENERATION OF HUMAN ENDODERMAL ORGANS IN PIG MODEL USING LINEAGE 
       RESTRICTED ENDODERMAL PRECURSORS

<130>  36429.0025P1

<140>  PCT/US19/28001
<141>  2019-04-17

<150>  US 62/659,111
<151>  2018-04-17

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
        195                 200                 205             


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
    210                 215                 220                 


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
225                 230                 235                 240 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
                245                 250                 255     


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
            260                 265                 270         


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
        275                 280                 285             


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
    290                 295                 300                 


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
305                 310                 315                 320 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
                325                 330                 335     


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
            340                 345                 350         


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
        355                 360                 365             


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
    370                 375                 380                 


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
385                 390                 395                 400 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
                405                 410                 415     


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
            420                 425                 430         


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440         


<210>  2
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         


Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     


Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         


Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             


Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         


<210>  3
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210>  4
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Pro Asp Ala Gly Tyr Ala Ser Asp Asp Gln Ser Gln Thr 
1               5                   10                  15      


Gln Ser Ala Leu Pro Ala Val Met Ala Gly Leu Gly Pro Cys Pro Trp 
            20                  25                  30          


Ala Glu Ser Leu Ser Pro Ile Gly Asp Met Lys Val Lys Gly Glu Ala 
        35                  40                  45              


Pro Ala Asn Ser Gly Ala Pro Ala Gly Ala Ala Gly Arg Ala Lys Gly 
    50                  55                  60                  


Glu Ser Arg Ile Arg Arg Pro Met Asn Ala Phe Met Val Trp Ala Lys 
65                  70                  75                  80  


Asp Glu Arg Lys Arg Leu Ala Gln Gln Asn Pro Asp Leu His Asn Ala 
                85                  90                  95      


Glu Leu Ser Lys Met Leu Gly Lys Ser Trp Lys Ala Leu Thr Leu Ala 
            100                 105                 110         


Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val Gln His 
        115                 120                 125             


Met Gln Asp His Pro Asn Tyr Lys Tyr Arg Pro Arg Arg Arg Lys Gln 
    130                 135                 140                 


Val Lys Arg Leu Lys Arg Val Glu Gly Gly Phe Leu His Gly Leu Ala 
145                 150                 155                 160 


Glu Pro Gln Ala Ala Ala Leu Gly Pro Glu Gly Gly Arg Val Ala Met 
                165                 170                 175     


Asp Gly Leu Gly Leu Gln Phe Pro Glu Gln Gly Phe Pro Ala Gly Pro 
            180                 185                 190         


Pro Leu Leu Pro Pro His Met Gly Gly His Tyr Arg Asp Cys Gln Ser 
        195                 200                 205             


Leu Gly Ala Pro Pro Leu Asp Gly Tyr Pro Leu Pro Thr Pro Asp Thr 
    210                 215                 220                 


Ser Pro Leu Asp Gly Val Asp Pro Asp Pro Ala Phe Phe Ala Ala Pro 
225                 230                 235                 240 


Met Pro Gly Asp Cys Pro Ala Ala Gly Thr Tyr Ser Tyr Ala Gln Val 
                245                 250                 255     


Ser Asp Tyr Ala Gly Pro Pro Glu Pro Pro Ala Gly Pro Met His Pro 
            260                 265                 270         


Arg Leu Gly Pro Glu Pro Ala Gly Pro Ser Ile Pro Gly Leu Leu Ala 
        275                 280                 285             


Pro Pro Ser Ala Leu His Val Tyr Tyr Gly Ala Met Gly Ser Pro Gly 
    290                 295                 300                 


Ala Gly Gly Gly Arg Gly Phe Gln Met Gln Pro Gln His Gln His Gln 
305                 310                 315                 320 


His Gln His Gln His His Pro Pro Gly Pro Gly Gln Pro Ser Pro Pro 
                325                 330                 335     


Pro Glu Ala Leu Pro Cys Arg Asp Gly Thr Asp Pro Ser Gln Pro Ala 
            340                 345                 350         


Glu Leu Leu Gly Glu Val Asp Arg Thr Glu Phe Glu Gln Tyr Leu His 
        355                 360                 365             


Phe Val Cys Lys Pro Glu Met Gly Leu Pro Tyr Gln Gly His Asp Ser 
    370                 375                 380                 


Gly Val Asn Leu Pro Asp Ser His Gly Ala Ile Ser Ser Val Val Ser 
385                 390                 395                 400 


Asp Ala Ser Ser Ala Val Tyr Tyr Cys Asn Tyr Pro Asp Val 
                405                 410                 


<210>  5
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Thr Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Thr Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Thr Ile Arg Arg Lys Ala Glu Leu Ala Ala Thr Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Ser Gly Ser Val Pro Gly Val Leu Gly Pro Thr Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Thr Val Thr Gln 
305                 310             


<210>  6
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Ala Ser Ala Pro Thr Tyr Pro Ser Leu Tyr Ser Ser Tyr His Gln 
1               5                   10                  15      


Gly Cys Leu Val Asn Pro Thr Gly Asn Leu Pro Met Trp Ser Asn Gln 
            20                  25                  30          


Thr Trp Asn Asn Ser Thr Trp Ser Asn Gln Thr Gln Asn Ile Gln Ser 
        35                  40                  45              


Trp Ser Asn His Ser Trp Asn Thr Gln Thr Trp Cys Thr Gln Ser Trp 
    50                  55                  60                  


Asn Asn Gln Ala Trp Asn Ser Pro Phe Tyr Asn Cys Gly Glu Glu Ser 
65                  70                  75                  80  


Leu Gln Ser Cys Met Gln Phe Gln Pro Asn Ser Pro Ala Ser Asp Leu 
                85                  90                  95      


Glu Ala Ala Leu Glu Ala Ala Gly Glu Gly Leu Asn Val Ile Gln Gln 
            100                 105                 110         


Thr Thr Arg Tyr Phe Ser Thr Pro Gln Thr Met Asp Leu Phe Leu Asn 
        115                 120                 125             


Tyr Ser Met Asn Met Gln Pro Glu Asp Val 
    130                 135             


<210>  7
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB forward primer

<400>  8
gtggacatca ggaaggacct cta                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB reverse primer

<400>  9
gtggacatca ggaaggacct cta                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AFP forward primer

<400>  10
gtggacatca ggaaggacct cta                                               23


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AFP reverse primer

<400>  11
aaggggtgcc ttcttgctat                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK8 forward primer

<400>  12
tctgggatgc agaacatgag                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK8 reverse primer

<400>  13
ggctgtagtt gaagcctgga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK18 forward primer

<400>  14
gcaagttctg tggacaatgc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK18 reverse primer

<400>  15
gccagctccg tctcatactt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK19 forward primer

<400>  16
gccagctccg tctcatactt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK18 reverse primer

<400>  17
gccagctccg tctcatactt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK19 forward primer

<400>  18
ctgaaggaag agctggccta                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CK19 reverse primer

<400>  19
tcaacctcca cactgacctg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCR4 5' primer

<400>  20
cagcaagggt gtgagtttga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCR4 3' primer

<400>  21
tccaaggaaa gcgtagagga                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cdh1 5' PRIMER

<400>  22
cacctcacgg gaattgtctt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDH1 3' primer

<400>  23
ttatcagcac ccacgcaata                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DKK1 5' primer

<400>  24
aggctcttgg aaccctgact                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  DKK1 3' primer

<400>  25
ccaaaggact caaggcagag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EPCAM 5' primer

<400>  26
ccaaaaggat ggacctgaga                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EPCAM 3

<400>  27
agcctgtaga ccctgcattg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXA2 5' primer

<400>  28
ataaggaggg caagggaaaa                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXA2 3' primer

<400>  29
agtcaaaatt cgcaggtgct                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GATA4 5' primer

<400>  30
tctcggaagg cagagagtgt                                                   20


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GATA4 3' primer

<400>  31
caggcgttgc acaggtagt                                                    19


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GATA6 5' primer

<400>  32
atcaccatca ccacccaagt                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GATA6 3' primer

<400>  33
cgcgactctg tagactgtgc                                                   20


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GPC1 5' primer

<400>  34
ccaggatgcc agtgatgac                                                    19


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GPC1 3' primer

<400>  35
tggagctttt cttgctgacc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSC 5' primer

<400>  36
gaagccctgg agaacctctt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSC 3' primer

<400>  37
cggtttttga accagacctc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF 5' primer

<400>  38
ctcagcaacg gacagatgtg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HNF 3' primer

<400>  39
caggagcttg tagggctcag                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG 5' primer

<400>  40
cccccttctt caactcaaca                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG 3' primer

<400>  41
cttcaggccc ataaacctca                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCT4 5' primer

<400>  42
gctggagccg aaccccgagg                                                   20


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCT4 3' primer

<400>  43
caccttccca aagagaaccc ccaaa                                             25


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDGFR 5' primer

<400>  44
caggttggag ggagatggac                                                   20


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDGF 3' primer

<400>  45
agttgcggag gttggatt                                                     18


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RSN18 5' primer

<400>  46
agttgcggag gttggatt                                                     18


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RN18S 3' primer

<400>  47
cggacacgga caggattgac                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SALL4 5' primer

<400>  48
caggagtacc agagccgaag                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SALL4 3' primer

<400>  49
acctcgggag acttggactt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SNAIL 5' primer

<400>  50
ttttcagcag ccctatgacc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SNAIL 3' primer

<400>  51
ccaggagaga gtcccagatg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2 5' primer

<400>  52
aacagcccag accgagttaa                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2 3' primer

<400>  53
gttgtgcatc ttggggttct                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX7 5' primer

<400>  54
ggctagtgaa agccaactcg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX7 3' primer

<400>  55
tttgcctgcc ttgagagaat                                                   20


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX17 5' primer

<400>  56
tggttgaatc ttgaggtctg c                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX17 3' primer

<400>  57
cagggtgtag gtgtgtgatg a                                                 21


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPARC 5' primer

<400>  58
ggaccatcag tcctctggaa                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPARC 3' primer

<400>  59
agttctgcgt ctcccaaaga                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF 5' primer

<400>  60
gtcttcttcg gacgttaccg                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF 3' primer

<400>  61
gcatgaggag gaggaacaaa                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  uPA 5' primer

<400>  62
aagggctctg acattccatg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  uPA 3' primer

<400>  63
ccggctctta cactgacaca                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vimentin 5' primer

<400>  64
gtaccggaga caggtgcagt                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vimentin 3' primer

<400>  65
ttccacggca aagttctctt                                                   20


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP 5' primer

<400>  66
aagttcatct gcaccaccg                                                    19


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP 3' primer

<400>  67
tccttgaaga agatggtgcg                                                   20


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YWHAZ 5' primer

<400>  68
agtaggttgg gctccttgac ac                                                22


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YWHAZ 3' primer

<400>  69
gccgactgtg actttaaggt gc                                                22


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCOL 5' primer

<400>  70
gcatggagag aaggcatgat                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBC 3' primer

<400>  71
tcacagcgat ccagaaagaa                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGN3 5 ' primer

<400>  72
caccagaccg agcagtcttt                                                   20


<210>  73
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGN3 3' primer

<400>  73
ttggtgagtt tcgcatcgt                                                    19


