                               SEQUENCE LISTING

<110> SUMMA HEALTH
      NORTHEAST OHIO MEDICAL UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR THE TREATMENT OF ISCHEMIA AND 
      CARDIOMYOPATHY

<130> 116449-0310

<140> PCT/US2019/027967
<141> 2019-04-17

<150> 62/659,667
<151> 2018-04-18

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210> 2
<211> 413
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly 
                405                 410             


<210> 3
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 3
gccgcacttt cactctccgt cagccgcatt gcccgctcgg cgtccggccc ccgacccgcg       60

ctcgtccgcc cgcccgcccg cccgcccgcg ccatgaacgc caaggtcgtg gtcgtgctgg      120

tcctcgtgct gaccgcgctc tgcctcagcg acgggaagcc cgtcagcctg agctacagat      180

gcccatgccg attcttcgaa agccatgttg ccagagccaa cgtcaagcat ctcaaaattc      240

tcaacactcc aaactgtgcc cttcagattg tagcccggct gaagaacaac aacagacaag      300

tgtgcattga cccgaagcta aagtggattc aggagtacct ggagaaagct ttaaacaagt      360

aagcacaaca gccaaaaagg actttccgct agacccactc gaggaaaact aaaaccttgt      420

gagagatgaa agggcaaaga cgtgggggag ggggccttaa ccatgaggac caggtgtgtg      480

tgtggggtgg gcacattgat ctgggatcgg gcctgaggtt tgccagcatt tagaccctgc      540

atttatagca tacggtatga tattgcagct tatattcatc catgccctgt acctgtgcac      600

gttggaactt ttattactgg ggtttttcta agaaagaaat tgtattatca acagcatttt      660

caagcagtta gttccttcat gatcatcaca atcatcatca ttctcattct cattttttaa      720

atcaacgagt acttcaagat ctgaatttgg cttgtttgga gcatctcctc tgctcccctg      780

gggagtctgg gcacagtcag gtggtggctt aacagggagc tggaaaaagt gtcctttctt      840

cagacactga ggctcccgca gcagcgcccc tcccaagagg aaggcctctg tggcactcag      900

ataccgactg gggctgggcg ccgccactgc cttcacctcc tctttcaacc tcagtgattg      960

gctctgtggg ctccatgtag aagccactat tactgggact gtgctcagag acccctctcc     1020

cagctattcc tactctctcc ccgactccga gagcatgctt aatcttgctt ctgcttctca     1080

tttctgtagc ctgatcagcg ccgcaccagc cgggaagagg gtgattgctg gggctcgtgc     1140

cctgcatccc tctcctccca gggcctgccc cacagctcgg gccctctgtg agatccgtct     1200

ttggcctcct ccagaatgga gctggccctc tcctggggat gtgtaatggt ccccctgctt     1260

acccgcaaaa gacaagtctt tacagaatca aatgcaattt taaatctgag agctcgcttt     1320

gagtgactgg gttttgtgat tgcctctgaa gcctatgtat gccatggagg cactaacaaa     1380

ctctgaggtt tccgaaatca gaagcgaaaa aatcagtgaa taaaccatca tcttgccact     1440

accccctcct gaagccacag cagggtttca ggttccaatc agaactgttg gcaaggtgac     1500

atttccatgc ataaatgcga tccacagaag gtcctggtgg tatttgtaac tttttgcaag     1560

gcattttttt atatatattt ttgtgcacat ttttttttac gtttctttag aaaacaaatg     1620

tatttcaaaa tatatttata gtcgaacaat tcatatattt gaagtggagc catatgaatg     1680

tcagtagttt atacttctct attatctcaa actactggca atttgtaaag aaatatatat     1740

gatatataaa tgtgattgca gcttttcaat gttagccaca gtgtattttt tcacttgtac     1800

taaaattgta tcaaatgtga cattatatgc actagcaata aaatgctaat tgtttcatgg     1860

tataaacgtc ctactgtatg tgggaattta tttacctgaa ataaaattca ttagttgtta     1920

gtgatggagc ttaaaaaaaa                                                 1940


<210> 4
<211> 93
<212> PRT
<213> Homo sapiens

<400> 4
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210> 5
<211> 350
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His 
            340                 345                 350 


<210> 6
<211> 3807
<212> DNA
<213> Homo sapiens

<400> 6
aacttcagtt tgttggctgc ggcagcaggt agcaaagtga cgccgagggc ctgagtgctc       60

cagtagccac cgcatctgga gaaccagcgg ttaccatgga ggggatcagt gtaagtccag      120

tttcaacctg ctttgtcata aatgtacaaa cgtttgaact tagagcgcag cccctctccg      180

agcgggcaga agcggccagg acattggagg tacccgtact ccaaaaaagg gtcaccgaaa      240

ggagttttct tgaccatgcc tatatagtgc gggtgggtgg ggggggagca ggattggaat      300

ctttttctct gtgagtcgag gagaaacgac tggaaagagc gttccagtgg ctgcatgtgt      360

ctcccccttg agtcccgccg cgcgcggcgg cttgcacgct gtttgcaaac gtaagaacat      420

tctgtgcaca agtgcagaga aggcgtgcgc gctgcctcgg gactcagacc accggtctct      480

tccttgggga agcggggatg tcttggagcg agttacattg tctgaattta gaggcggagg      540

gcggcgtgcc tgggctgagt tcccaggagg agattgcgcc cgctttaact tcggggttaa      600

gcgcctggtg actgttcttg acactgggtg cgtgtttgtt aaactctgtg cggccgacgg      660

agctgtgcca gtctcccagc acagtaggca gagggcggga gaggcgggtg gacccaccgc      720

gccgatcctc tgaggggatc gagtggtggc agcagctagg agttgatccg cccgcgcgct      780

ttgggtttga gggggaaaac cttcccgccg tccgaagcgc gcctcttccc cacggccgcg      840

agtgggtcct gcagttcgag agtttggggt cgtgcagagg tcagcggagt ggtttgacct      900

cccctttgac accgcgcagc tgccagccct gagatttgcg ctccggggat aggagcgggt      960

acggggtgag gggcgggggc ggttaagacc gcacctgggc tgccaggtcg ccgccgcgaa     1020

gactggcagg tgcaagtggg gaaaccgttt ggctctctcc gagtccagtt gtgatgttta     1080

accgtcggtg gtttccagaa accttttgaa accctcttgc tagggagttt ttggtttcct     1140

gcagcggcgc gcaattcaaa gacgctcgcg gcggagccgc ccagtcgctc cccagcaccc     1200

tgtgggacag agcctggcgt gtcgcccagc ggagcccctg cagcgctgct tgcgggcggt     1260

tggcgtgggt gtagtgggca gccgcggcgg cccggggctg gacgacccgg ccccccgcgt     1320

gcccaccgcc tggaggcttc cagctgccca cctccggccg ggttaactgg atcagtggcg     1380

gggtaatggg aagccacccg ggagagtgag gaaatgaaac ttggggcgag gaccacgggt     1440

gcagaccccg ttaccttctc cacccaggaa aatgccccgc tccctaacgt cccaaacgcg     1500

ccaagtgata aacacgagga tggcaagaga cccacacacc ggaggagcgc ccgcttgggg     1560

gaggaggtgc cgtttgttca ttttctgaca ctcccgccca atatacccca agcaccgaag     1620

ggccttcgtt ttaagaccgc attctcttta cccactacaa gttgcttgaa gcccagaatg     1680

gtttgtattt aggcaggcgt gggaaaatta agtttttgcg ctttaggaga atgagtcttt     1740

gcaacgcccc cgccctcccc ccgtgatcct cccttctccc ctcttccctc cctgggcgaa     1800

aaacttctta caaaaagtta atcactgccc ctcctagcag cacccacccc accccccacg     1860

ccgcctggga gtggcctctt tgtgtgtatt ttttttttcc tcctaaggaa ggtttttttt     1920

cttccctcta gtgggcgggg cagaggagtt agccaagatg tgactttgaa accctcagcg     1980

tctcagtgcc cttttgttct aaacaaagaa ttttgtaatt ggttctacca aagaaggata     2040

taatgaagtc actatgggaa aagatgggga ggagagttgt aggattctac attaattctc     2100

ttgtgccctt agcccactac ttcagaattt cctgaagaaa gcaagcctga attggttttt     2160

taaattgctt taaaaatttt ttttaactgg gttaatgctt gctgaattgg aagtgaatgt     2220

ccattccttt gcctcttttg cagatataca cttcagataa ctacaccgag gaaatgggct     2280

caggggacta tgactccatg aaggaaccct gtttccgtga agaaaatgct aatttcaata     2340

aaatcttcct gcccaccatc tactccatca tcttcttaac tggcattgtg ggcaatggat     2400

tggtcatcct ggtcatgggt taccagaaga aactgagaag catgacggac aagtacaggc     2460

tgcacctgtc agtggccgac ctcctctttg tcatcacgct tcccttctgg gcagttgatg     2520

ccgtggcaaa ctggtacttt gggaacttcc tatgcaaggc agtccatgtc atctacacag     2580

tcaacctcta cagcagtgtc ctcatcctgg ccttcatcag tctggaccgc tacctggcca     2640

tcgtccacgc caccaacagt cagaggccaa ggaagctgtt ggctgaaaag gtggtctatg     2700

ttggcgtctg gatccctgcc ctcctgctga ctattcccga cttcatcttt gccaacgtca     2760

gtgaggcaga tgacagatat atctgtgacc gcttctaccc caatgacttg tgggtggttg     2820

tgttccagtt tcagcacatc atggttggcc ttatcctgcc tggtattgtc atcctgtcct     2880

gctattgcat tatcatctcc aagctgtcac actccaaggg ccaccagaag cgcaaggccc     2940

tcaagaccac agtcatcctc atcctggctt tcttcgcctg ttggctgcct tactacattg     3000

ggatcagcat cgactccttc atcctcctgg aaatcatcaa gcaagggtgt gagtttgaga     3060

acactgtgca caagtggatt tccatcaccg aggccctagc tttcttccac tgttgtctga     3120

accccatcct ctatgctttc cttggagcca aatttaaaac ctctgcccag cacgcactca     3180

cctctgtgag cagagggtcc agcctcaaga tcctctccaa aggaaagcga ggtggacatt     3240

catctgtttc cactgagtct gagtcttcaa gttttcactc cagctaacac agatgtaaaa     3300

gacttttttt tatacgataa ataacttttt tttaagttac acatttttca gatataaaag     3360

actgaccaat attgtacagt ttttattgct tgttggattt ttgtcttgtg tttctttagt     3420

ttttgtgaag tttaattgac ttatttatat aaattttttt tgtttcatat tgatgtgtgt     3480

ctaggcagga cctgtggcca agttcttagt tgctgtatgt ctcgtggtag gactgtagaa     3540

aagggaactg aacattccag agcgtgtagt gaatcacgta aagctagaaa tgatccccag     3600

ctgtttatgc atagataatc tctccattcc cgtggaacgt ttttcctgtt cttaagacgt     3660

gattttgctg tagaagatgg cacttataac caaagcccaa agtggtatag aaatgctggt     3720

ttttcagttt tcaggagtgg gttgatttca gcacctacag tgtacagtct tgtattaagt     3780

tgttaataaa agtacatgtt aaactta                                         3807


