                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  ENGINEERED REGULATORY T CELL

<130>  P112692PCT

<140>  PCT/GB2019/051097
<141>  2019-04-17

<150>  GB 1806330.5
<151>  2018-04-18

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UniProtKB accession P02686-1

<400>  1

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210>  2
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 100-140

<400>  2

Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser 
1               5                   10                  15      


Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala 
            20                  25                  30          


Ser Asp Tyr Lys Ser Ala His Lys Gly 
        35                  40      


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 111-129

<400>  3

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly 
1               5                   10                  15      


Tyr Gly Gly 
            


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 116-123

<400>  4

Trp Gly Ala Glu Gly Gln Arg Pro 
1               5               


<210>  5
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3alpha

<400>  5

Thr Val Tyr Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly Thr 
1               5                   10                  15      


Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp 
            20                  25              


<210>  6
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3beta

<400>  6

Ser Ala Arg Gly Gly Ser Tyr Asn Ser Pro Leu His Phe Gly Asn Gly 
1               5                   10                  15      


Thr Arg Leu Thr Val Thr Glu 
            20              


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1alpha

<400>  7

Thr Ile Ser Gly Thr Asp Tyr 
1               5           


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2alpha

<400>  8

Gly Leu Thr Ser Asn 
1               5   


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3alpha

<400>  9

Thr Val Tyr Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly Thr 
1               5                   10                  15      


Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp 
            20                  25              


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1beta

<400>  10

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2beta

<400>  11

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3beta

<400>  12

Ser Ala Arg Gly Gly Ser Tyr Asn Ser Pro Leu His Phe Gly Asn Gly 
1               5                   10                  15      


Thr Arg Leu Thr Val Thr Glu 
            20              


<210>  13
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human alpha V-region and murine constant-region

<400>  13

Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu 
1               5                   10                  15      


Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr 
            20                  25                  30          


Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile 
        35                  40                  45              


His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile 
    50                  55                  60                  


Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu 
65                  70                  75                  80  


Arg Asp Ala Ala Val Tyr Tyr Cys Thr Val Tyr Gly Gly Ala Thr Asn 
                85                  90                  95      


Lys Leu Ile Phe Gly Thr Gly Thr Leu Leu Ala Val Gln Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met 
    210                 215                 220                 


Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly 
                245                 250 


<210>  14
<211>  289
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human beta V-region and murine constant-region

<400>  14

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Ala Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Arg Gly Gly Ser Tyr Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        115                 120                 125             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                165                 170                 175     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    210                 215                 220                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
        275                 280                 285             


Ser 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  15

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  16

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu 
            20                  25  


<210>  17
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3 polypeptide - UniProtKB accession: Q9BZS1

<400>  17

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  18
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha Chain: V-region, MS2.3C8-alpha-variable(Va26-2) nucleotide 
       sequence

<400>  18
cccggaccga tgaagctcgt gaccagcatc accgtgctgc tgagcctggg cattatgggc       60

gacgccaaga ccacccagcc caacagcatg gaaagcaacg aagaggaacc cgtgcatctg      120

ccctgcaacc acagcaccat cagcggcacc gactacatcc actggtacag acagctgccc      180

agccagggcc ccgagtatgt gatccacggc ctgaccagca acgtgaacaa ccggatggcc      240

tccctggcca ttgccgagga cagaaagagc agcaccctga tcctgcaccg ggccaccctg      300

agagatgccg ccgtgtacta ctgcaccgtg tacggcggag ccaccaacaa gctgatcttc      360

ggcaccggca cactgctggc cgtgcagccc aatatccaga accccgac                   408


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha Chain: V-region, MS2.3C8-alpha-variable(Va26-2) amino acid 
       sequence

<400>  19

Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu 
1               5                   10                  15      


Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr 
            20                  25                  30          


Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile 
        35                  40                  45              


His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile 
    50                  55                  60                  


Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu 
65                  70                  75                  80  


Arg Asp Ala Ala Val Tyr Tyr Cys Thr Val Tyr Gly Gly Ala Thr Asn 
                85                  90                  95      


Lys Leu Ile Phe Gly Thr Gly Thr Leu Leu Ala Val Gln Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Asp 
        115     


<210>  20
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS2.3C8 Beta Chain: human V-region nucleotide sequence

<400>  20
atgcttctcc ttctgctgct gctgggaccc ggcatctcac tgctgctgcc tggatctctg       60

gccggctctg gactgggagc tgtggtgtct cagcacccct cttgggtcat cgccaagagc      120

ggcaccagcg tgaagatcga gtgcagaagc ctggacttcc aggccaccac catgttttgg      180

tacaggcagt tccccaagca gagcctgatg ctgatggcca cctccaacga gggcagcaag      240

gccacatatg agcagggcgt ggaaaaggac aagttcctga tcaaccacgc cagcctgacc      300

ctgtccaccc tgacagtgac aagcgcccac cccgaggact ccagcttcta catctgtagc      360

gccagaggcg gcagctacaa cagccctctg cactttggca acggcacccg gctgaccgtg      420

acc                                                                    423


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MS2.3C8 Beta Chain: human V-region amino acid sequence

<400>  21

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Ala Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Ser Cys Ser Trp Pro 
        35                  40                  45              


Pro Pro Thr Arg Ala Pro Arg Pro Pro Thr Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Thr Ser Ser Ser Ser Thr Thr Pro Pro Ser Pro Ser Pro Pro Ser Pro 
65                  70                  75                  80  


Ser Pro Pro Pro Thr Pro Arg Thr Pro Pro Ser Thr Ser Ala Pro Pro 
                85                  90                  95      


Ala Ala Ala Pro Thr Thr Pro Pro Ser Thr Ser Ala Thr Ala Pro 
            100                 105                 110     


<210>  22
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MS2.3C8-alpha-variable amino acid sequence excluding CDR 
       sequences

<400>  22

Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu 
1               5                   10                  15      


Pro Val His Leu Pro Cys Asn His Ser Ile His Trp Tyr Arg Gln Leu 
            20                  25                  30          


Pro Ser Gln Gly Pro Glu Tyr Val Ile His Val Asn Asn Arg Met Ala 
        35                  40                  45              


Ser Leu Ala Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His 
    50                  55                  60                  


Arg Ala Thr Leu Arg Asp Ala Ala Val Tyr Tyr Cys 
65                  70                  75      


<210>  23
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MS2.3C8-beta-variable amino acid sequence excluding CDR sequences

<400>  23

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Ala Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Met Phe Trp Tyr Arg Gln 
            20                  25                  30          


Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Thr Tyr Glu Gln Gly 
        35                  40                  45              


Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser 
    50                  55                  60                  


Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile 
65                  70                  75                  80  


Cys 
    


<210>  24
<211>  1352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding FOXP3

<400>  24
gaattcgtcg acatgcccaa ccccagaccc ggcaagcctt ctgccccttc tctggccctg       60

ggaccatctc ctggcgcctc cccatcttgg agagccgccc ctaaagccag cgatctgctg      120

ggagctagag gccctggcgg cacattccag ggcagagatc tgagaggcgg agcccacgcc      180

tctagcagca gcctgaatcc catgccccct agccagctgc agctgcctac actgcctctc      240

gtgatggtgg cccctagcgg agctagactg ggccctctgc ctcatctgca ggctctgctg      300

caggaccggc cccactttat gcaccagctg agcaccgtgg acgcccacgc cagaacacct      360

gtgctgcagg tgcaccccct ggaaagccct gccatgatca gcctgacccc tccaaccaca      420

gccaccggcg tgttcagcct gaaggccaga cctggactgc cccctggcat caatgtggcc      480

agcctggaat gggtgtcccg cgaacctgcc ctgctgtgca ccttccccaa tcctagcgcc      540

cccagaaagg acagcacact gtctgccgtg ccccagagca gctatcccct gctggctaac      600

ggcgtgtgca agtggcctgg ctgcgagaag gtgttcgagg aacccgagga cttcctgaag      660

cactgccagg ccgaccatct gctggacgag aaaggcagag cccagtgcct gctgcagcgc      720

gagatggtgc agtccctgga acagcagctg gtgctggaaa aagaaaagct gagcgccatg      780

caggcccacc tggccggaaa gatggccctg acaaaagcca gcagcgtggc cagctccgac      840

aagggcagct gttgtatcgt ggccgctggc agccagggac ctgtggtgcc tgcttggagc      900

ggacctagag aggcccccga tagcctgttt gccgtgcgga gacacctgtg gggcagccac      960

ggcaactcta ccttccccga gttcctgcac aacatggact acttcaagtt ccacaacatg     1020

aggcccccct tcacctacgc caccctgatc agatgggcca ttctggaagc ccccgagaag     1080

cagcggaccc tgaacgagat ctaccactgg tttacccgga tgttcgcctt cttccggaac     1140

caccccgcca cctggaagaa cgccatccgg cacaatctga gcctgcacaa gtgcttcgtg     1200

cgggtggaaa gcgagaaggg cgccgtgtgg acagtggacg agctggaatt tcggaagaag     1260

cggtcccaga ggcccagccg gtgtagcaat cctacacctg gccctgaggg cagaggaagt     1320

ctgctaacat gcggtgacgt cgaggagaat cc                                   1352


<210>  25
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of FOXP3

<400>  25

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Val Glu Glu Leu Ser Ala Met Gln Ala His Leu Ala 
                245                 250                 255     


Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser Asp Lys 
            260                 265                 270         


Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val Val Pro 
        275                 280                 285             


Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala Val Arg 
    290                 295                 300                 


Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu Phe Leu 
305                 310                 315                 320 


His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro Phe Thr 
                325                 330                 335     


Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln 
            340                 345                 350         


Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe Ala Phe 
        355                 360                 365             


Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His Asn Leu 
    370                 375                 380                 


Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly Ala Val 
385                 390                 395                 400 


Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro 
                405                 410                 415     


Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro Glu Gly Arg Gly Ser Leu 
            420                 425                 430         


Leu Thr Cys Gly Asp Val Glu Glu Asn 
        435                 440     


<210>  26
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UniProtKB accession P02686-5

<400>  26

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 
            100                 105                 110         


Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 
        115                 120                 125             


Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 
    130                 135                 140                 


Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
145                 150                 155                 160 


Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
                165                 170     


<210>  27
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXP3 polynucleotide sequence

<400>  27
atgcccaacc ccaggcctgg caagccctcg gccccttcct tggcccttgg cccatcccca       60

ggagcctcgc ccagctggag ggctgcaccc aaagcctcag acctgctggg ggcccggggc      120

ccagggggaa ccttccaggg ccgagatctt cgaggcgggg cccatgcctc ctcttcttcc      180

ttgaacccca tgccaccatc gcagctgcag ctgcccacac tgcccctagt catggtggca      240

ccctccgggg cacggctggg ccccttgccc cacttacagg cactcctcca ggacaggcca      300

catttcatgc accagctctc aacggtggat gcccacgccc ggacccctgt gctgcaggtg      360

caccccctgg agagcccagc catgatcagc ctcacaccac ccaccaccgc cactggggtc      420

ttctccctca aggcccggcc tggcctccca cctgggatca acgtggccag cctggaatgg      480

gtgtccaggg agccggcact gctctgcacc ttcccaaatc ccagtgcacc caggaaggac      540

agcacccttt cggctgtgcc ccagagctcc tacccactgc tggcaaatgg tgtctgcaag      600

tggcccggat gtgagaaggt cttcgaagag ccagaggact tcctcaagca ctgccaggcg      660

gaccatcttc tggatgagaa gggcagggca caatgtctcc tccagagaga gatggtacag      720

tctctggagc agcagctggt gctggagaag gagaagctga gtgccatgca ggcccacctg      780

gctgggaaaa tggcactgac caaggcttca tctgtggcat catccgacaa gggctcctgc      840

tgcatcgtag ctgctggcag ccaaggccct gtcgtcccag cctggtctgg cccccgggag      900

gcccctgaca gcctgtttgc tgtccggagg cacctgtggg gtagccatgg aaacagcaca      960

ttcccagagt tcctccacaa catggactac ttcaagttcc acaacatgcg accccctttc     1020

acctacgcca cgctcatccg ctgggccatc ctggaggctc cagagaagca gcggacactc     1080

aatgagatct accactggtt cacacgcatg tttgccttct tcagaaacca tcctgccacc     1140

tggaagaacg ccatccgcca caacctgagt ctgcacaagt gctttgtgcg ggtggagagc     1200

gagaaggggg ctgtgtggac cgtggatgag ctggagttcc gcaagaaacg gagccagagg     1260

cccagcaggt gttccaaccc tacacctggc ccctga                               1296


