                         SEQUENCE LISTING

<110>  University of Copenhagen
       Herlev Hospital
       Straten, Per Thor
 
<120>  A MerTK ligand for Adoptive T Cell Cancer Therapy

<130>  P4812PC00

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                85                  90                  95      


Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
            100                 105                 110         


Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
        115                 120                 125             


Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
    130                 135                 140                 


Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
145                 150                 155                 160 


Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                165                 170                 175     


Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
            180                 185                 190         


Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
        195                 200                 205             


Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
    210                 215                 220                 


Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
225                 230                 235                 240 


Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                245                 250                 255     


Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
            260                 265                 270         


Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
        275                 280                 285             


Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
    290                 295                 300                 


Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
305                 310                 315                 320 


Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                325                 330                 335     


Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
            340                 345                 350         


Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
        355                 360                 365             


Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
    370                 375                 380                 


Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
385                 390                 395                 400 


Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                405                 410                 415     


Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
            420                 425                 430         


Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
        435                 440                 445             


Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
    450                 455                 460                 


Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
465                 470                 475                 480 


Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                485                 490                 495     


Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
            500                 505                 510         


Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
        515                 520                 525             


Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
    530                 535                 540                 


Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
545                 550                 555                 560 


Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                565                 570                 575     


Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
            580                 585                 590         


Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
        595                 600                 605             


Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
    610                 615                 620                 


Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
625                 630                 635                 640 


Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                645                 650                 655     


Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
            660                 665                 670         


Thr Lys Asn Ser 
        675     


<210>  2
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Arg Thr Tyr Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser Ile 
1               5                   10                  15      


Asp His Ser Ala Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile Glu 
            20                  25                  30          


Val Gln Leu Lys Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly Asp 
        35                  40                  45              


Val Ile Asn Asn Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu Glu 
    50                  55                  60                  


His Ser Ile Ser Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile Asn 
65                  70                  75                  80  


Lys Pro Gly Pro Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr Lys 
                85                  90                  95      


Val Tyr Phe Ala Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile Lys 
            100                 105                 110         


Pro Ile Asn Pro Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu Met 
        115                 120                 125             


Lys Gln Gly 
    130     


<210>  3
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser Gly 
1               5                   10                  15      


Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser Glu 
            20                  25                  30          


Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr Arg 
        35                  40                  45              


Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu Phe 
    50                  55                  60                  


Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile Glu 
65                  70                  75                  80  


Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp Lys 
                85                  90                  95      


Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp Val 
            100                 105                 110         


Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met Glu 
        115                 120                 125             


Val Asn Ile Asn Gly Val 
    130                 


<210>  4
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Leu Ala Glu Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg 
1               5                   10                  15      


Leu Pro Glu Ile Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr 
            20                  25                  30          


Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala 
        35                  40                  45              


Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys 
    50                  55                  60                  


Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn 
65                  70                  75                  80  


Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser 
                85                  90                  95      


Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro 
            100                 105                 110         


Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala 
        115                 120                 125             


Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro 
    130                 135                 140                 


Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala 
145                 150                 155                 160 


Ser Gly Ile Lys Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys 
                165                 170                 175 


<210>  5
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp Tyr Asn Asn 
1               5                   10                  15      


Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu Asn Ile Arg 
            20                  25                  30          


Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser Gly Asn Asn 
        35                  40                  45              


Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser Glu Lys Ser 
    50                  55                  60                  


Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr Arg Ile Gln 
65                  70                  75                  80  


Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu Phe Arg Val 
                85                  90                  95      


Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile Glu Thr Ile 
            100                 105                 110         


Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp Lys Ala Met 
        115                 120                 125             


Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp Val Pro Phe 
    130                 135                 140                 


Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met Glu Val Asn 
145                 150                 155                 160 


Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser Lys His Asn 
                165                 170                 175     


Asp Ile Arg Ala His Ser Cys 
            180             


<210>  6
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Leu Tyr Leu Ala Glu Gln Phe Ala Gly Val Val Leu Tyr Leu Lys 
1               5                   10                  15      


Phe Arg Leu Pro Glu Ile Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg 
            20                  25                  30          


Thr Tyr Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser Ile Asp His 
        35                  40                  45              


Ser Ala Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile Glu Val Gln 
    50                  55                  60                  


Leu Lys Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly Asp Val Ile 
65                  70                  75                  80  


Asn Asn Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu Glu His Ser 
                85                  90                  95      


Ile Ser Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile Asn Lys Pro 
            100                 105                 110         


Gly Pro Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr 
        115                 120                 125             


Phe Ala Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile Lys Pro Ile 
    130                 135                 140                 


Asn Pro Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu Met Lys Gln 
145                 150                 155                 160 


Gly Ala Ser Gly Ile Lys Glu Ile Ile Gln Glu Lys Gln Asn Lys His 
                165                 170                 175     


Cys Leu Val Thr Val Glu Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile 
            180                 185                 190         


Ala Gln Phe His Ile Asp Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp 
        195                 200                 205             


His Val Asn Val Thr Leu Asn Ile Arg Pro Ser Thr Gly Thr Gly Val 
    210                 215                 220                 


Met Leu Ala Leu Val Ser Gly Asn Asn Thr Val Pro Phe Ala Val Ser 
225                 230                 235                 240 


Leu Val Asp Ser Thr Ser Glu Lys Ser Gln Asp Ile Leu Leu Ser Val 
                245                 250                 255     


Glu Asn Thr Val Ile Tyr Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp 
            260                 265                 270         


Gln Gln Ser His Leu Glu Phe Arg Val Asn Arg Asn Asn Leu Glu Leu 
        275                 280                 285             


Ser Thr Pro Leu Lys Ile Glu Thr Ile Ser His Glu Asp Leu Gln Arg 
    290                 295                 300                 


Gln Leu Ala Val Leu Asp Lys Ala Met Lys Ala Lys Val Ala Thr Tyr 
305                 310                 315                 320 


Leu Gly Gly Leu Pro Asp Val Pro Phe Ser Ala Thr Pro Val Asn Ala 
                325                 330                 335     


Phe Tyr Asn Gly Cys Met Glu Val Asn Ile Asn Gly Val Gln Leu Asp 
            340                 345                 350         


Leu Asp Glu Ala Ile Ser Lys His Asn Asp Ile Arg Ala His Ser Cys 
        355                 360                 365             


<210>  7
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Arg Thr Tyr Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser Ile 
1               5                   10                  15      


Asp His Ser Ala Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile Glu 
            20                  25                  30          


Val Gln Leu Lys Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly Asp 
        35                  40                  45              


Val Ile Asn Asn Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu Glu 
    50                  55                  60                  


His Ser Ile Ser Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile Asn 
65                  70                  75                  80  


Lys Pro Gly Pro Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr Lys 
                85                  90                  95      


Val Tyr Phe Ala Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile Lys 
            100                 105                 110         


Pro Ile Asn Pro Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu Met 
        115                 120                 125             


Lys Gln Gly Ala Ser Gly Ile Lys Glu Ile Ile Gln Glu Lys Gln Asn 
    130                 135                 140                 


Lys His Cys Leu Val Thr Val Glu Lys Gly Ser Tyr Tyr Pro Gly Ser 
145                 150                 155                 160 


Gly Ile Ala Gln Phe His Ile Asp Tyr Asn Asn Val Ser Ser Ala Glu 
                165                 170                 175     


Gly Trp His Val Asn Val Thr Leu Asn Ile Arg Pro Ser Thr Gly Thr 
            180                 185                 190         


Gly Val Met Leu Ala Leu Val Ser Gly Asn Asn Thr Val Pro Phe Ala 
        195                 200                 205             


Val Ser Leu Val Asp Ser Thr Ser Glu Lys Ser Gln Asp Ile Leu Leu 
    210                 215                 220                 


Ser Val Glu Asn Thr Val Ile Tyr Arg Ile Gln Ala Leu Ser Leu Cys 
225                 230                 235                 240 


Ser Asp Gln Gln Ser His Leu Glu Phe Arg Val Asn Arg Asn Asn Leu 
                245                 250                 255     


Glu Leu Ser Thr Pro Leu Lys Ile Glu Thr Ile Ser His Glu Asp Leu 
            260                 265                 270         


Gln Arg Gln Leu Ala Val Leu Asp Lys Ala Met Lys Ala Lys Val Ala 
        275                 280                 285             


Thr Tyr Leu Gly Gly Leu Pro Asp Val Pro Phe Ser Ala Thr Pro Val 
    290                 295                 300                 


Asn Ala Phe Tyr Asn Gly Cys Met Glu Val Asn Ile Asn Gly Val 
305                 310                 315                 


<210>  8
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Asn Ser Leu Leu Glu Glu Thr Lys Gly Asn Leu Glu Arg Glu Cys 
1               5                   10                  15      


Ile Glu Glu Leu Cys Asn Lys Glu Glu Ala Arg Glu Val Phe Glu Asn 
            20                  25                  30          


Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg 
        35                  40                  45              


Ser Phe Gln Thr Gly Leu Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala 
    50                  55                  60                  


Tyr Pro Asp Leu Arg Ser Cys Val Asn Ala Ile Pro Asp Gln Cys Ser 
65                  70                  75                  80  


Pro Leu Pro Cys Asn Glu Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys 
                85                  90                  95      


Ala Ser Phe Thr Cys Thr Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys 
            100                 105                 110         


Glu Phe Asp Ile Asn Glu Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly 
        115                 120                 125             


Cys Ser Gln Ile Cys Asp Asn Thr Pro Gly Ser Tyr His Cys Ser Cys 
    130                 135                 140                 


Lys Asn Gly Phe Val Met Leu Ser Asn Lys Lys Asp Cys Lys Asp Val 
145                 150                 155                 160 


Asp Glu Cys Ser Leu Lys Pro Ser Ile Cys Gly Thr Ala Val Cys Lys 
                165                 170                 175     


Asn Ile Pro Gly Asp Phe Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr 
            180                 185                 190         


Asn Leu Lys Ser Lys Ser Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn 
        195                 200                 205             


Met Cys Ala Gln Leu Cys Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr 
    210                 215                 220                 


Cys Asp Gly Lys Lys Gly Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys 
225                 230                 235                 240 


Glu Val Val Ser Val Cys Leu Leu Asn Leu Asp Thr Lys Tyr Glu Leu 
                245                 250                 255     


Leu Tyr Leu Ala Glu Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe 
            260                 265                 270         


Arg Leu Pro Glu Ile Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr 
        275                 280                 285             


Tyr Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser 
    290                 295                 300                 


Ala Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu 
305                 310                 315                 320 


Lys Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn 
                325                 330                 335     


Asn Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu Glu His Ser Ile 
            340                 345                 350         


Ser Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly 
        355                 360                 365             


Pro Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe 
    370                 375                 380                 


Ala Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn 
385                 390                 395                 400 


Pro Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly 
                405                 410                 415     


Ala Ser Gly Ile Lys Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys 
            420                 425                 430         


Leu Val Thr Val Glu Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala 
        435                 440                 445             


Gln Phe His Ile Asp Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His 
    450                 455                 460                 


Val Asn Val Thr Leu Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met 
465                 470                 475                 480 


Leu Ala Leu Val Ser Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu 
                485                 490                 495     


Val Asp Ser Thr Ser Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu 
            500                 505                 510         


Asn Thr Val Ile Tyr Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln 
        515                 520                 525             


Gln Ser His Leu Glu Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser 
    530                 535                 540                 


Thr Pro Leu Lys Ile Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln 
545                 550                 555                 560 


Leu Ala Val Leu Asp Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu 
                565                 570                 575     


Gly Gly Leu Pro Asp Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe 
            580                 585                 590         


Tyr Asn Gly Cys Met Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu 
        595                 600                 605             


Asp Glu Ala Ile Ser Lys His Asn Asp Ile Arg Ala His Ser Cys 
    610                 615                 620             


