                         SEQUENCE LISTING

<110>  ADAERATA, LIMITED PARTNERSHIP
 
<120>  METHODS OF PREVENTING OR TREATING NON-HEMATOPOIETIC SLAMF7 
       POSITIVE AND SLAMF7 NEGATIVE CANCERS

<130>  765/12810.678

<140>  N.A.
<141>  2019-04-15

<150>  US 62/658,243
<151>  2018-04-16

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  2
<211>  2908
<212>  DNA
<213>  homo sapiens

<400>  2
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

ggtcagcagc ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt      360

tccccctgaa gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc      420

ctcttgtcac catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg      480

agagagtaga cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg      540

actcagggat ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg      600

agtacgtgct gcatgtctac gagcacctgt caaagcctaa agtcaccatg ggtctgcaga      660

gcaataagaa tggcacctgt gtgaccaatc tgacatgctg catggaacat ggggaagagg      720

atgtgattta tacctggaag gccctggggc aagcagccaa tgagtcccat aatgggtcca      780

tcctccccat ctcctggaga tggggagaaa gtgatatgac cttcatctgc gttgccagga      840

accctgtcag cagaaacttc tcaagcccca tccttgccag gaagctctgt gaaggtgctg      900

ctgatgaccc agattcctcc atggtcctcc tgtgtctcct gttggtgccc ctcctgctca      960

gtctctttgt actggggcta tttctttggt ttctgaagag agagagacaa gaagagtaca     1020

ttgaagagaa gaagagagtg gacatttgtc gggaaactcc taacatatgc ccccattctg     1080

gagagaacac agagtacgac acaatccctc acactaatag aacaatccta aaggaagatc     1140

cagcaaatac ggtttactcc actgtggaaa taccgaaaaa gatggaaaat ccccactcac     1200

tgctcacgat gccagacaca ccaaggctat ttgcctatga gaatgttatc tagacagcag     1260

tgcactcccc taagtctctg ctcaaaaaaa aaacaattct cggcccaaag aaaacaatca     1320

gaagaattca ctgatttgac tagaaacatc aaggaagaat gaagaacgtt gacttttttc     1380

caggataaat tatctctgat gcttctttag atttaagagt tcataattcc atccactgct     1440

gagaaatctc ctcaaaccca gaaggtttaa tcacttcatc ccaaaaatgg gattgtgaat     1500

gtcagcaaac cataaaaaaa gtgcttagaa gtattcctat aaaaatgtaa atgcaaggtc     1560

acacatatta atgacagcct gttgtattaa tgatggctcc aggtcagtgt ctggagtttc     1620

attccatccc agggcttgga tgtcaggatt ataccaagag tcttgctacc aggagggcaa     1680

gaagaccaaa acagacagac aagtccagca gaagcagatg cacctgacaa aaatggatgt     1740

attaattggc tctataaact atgtgcccag cactatgctg agcttacact aattggtcag     1800

acatgctgtc tgccctcatg aaattggctc caaatgaatg aactactttc atgagcagtt     1860

gtagcaggcc tgaccacaga ttcccagagg gccaggtgtg gatccacagg acttgaaggt     1920

caaagttcac aaagatgaag aatcagggta gctgaccatg tttggcagat actataatgg     1980

agacacagaa gtgtgcatgg cccaaggaca aggacctcca gccaggcttc atttatgcac     2040

ttgtgctgca aaagaaaagt ctaggtttta aggctgtgcc agaacccatc ccaataaaga     2100

gaccgagtct gaagtcacat tgtaaatcta gtgtaggaga cttggagtca ggcagtgaga     2160

ctggtggggc acggggggca gtgggtactt gtaaaccttt aaagatggtt aattcattca     2220

atagatattt attaagaacc tatgcggccc ggcatggtgg ctcacacctg taatcccagc     2280

actttgggag gccaaggtgg gtgggtcatc tgaggtcagg agttcaagac cagcctggcc     2340

aacatggtga aaccccatct ctactaaaga tacaaaaatt tgctgagcgt ggtggtgtgc     2400

acctgtaatc ccagctactc gagaggccaa ggcatgagaa tcgcttgaac ctgggaggtg     2460

gaggttgcag tgagctgaga tggcaccact gcactccggc ctaggcaacg agagcaaaac     2520

tccaatacaa acaaacaaac aaacacctgt gctaggtcag tctggcacgt aagatgaaca     2580

tccctaccaa tacagagctc accatctctt atacttaagt gaaaaacatg gggaagggga     2640

aaggggaatg gctgcttttg atatgttccc tgacacatat cttgaatgga gacctcccta     2700

ccaagtgatg aaagtgttga aaaacttaat aacaaatgct tgttgggcaa gaatgggatt     2760

gaggattatc ttctctcaga aaggcattgt gaaggaattg agccagatct ctctccctac     2820

tgcaaaaccc tattgtagta aaaaagtctt ctttactatc ttaataaaac agatattgtg     2880

agattcacat acaaaaaaaa aaaaaaaa                                        2908


<210>  3
<211>  165
<212>  PRT
<213>  homo sapiens

<400>  3

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu Asn Asn 
        115                 120                 125             


Pro Lys Gly Arg Ser Ser Lys Tyr Gly Leu Leu His Cys Gly Asn Thr 
    130                 135                 140                 


Glu Lys Asp Gly Lys Ser Pro Leu Thr Ala His Asp Ala Arg His Thr 
145                 150                 155                 160 


Lys Ala Ile Cys Leu 
                165 


<210>  4
<211>  2411
<212>  DNA
<213>  homo sapiens

<400>  4
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

ggtcagcagc ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt      360

tccccctgaa gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc      420

ctcttgtcac catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg      480

agagagtaga cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg      540

actcagggat ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg      600

agtacgtgct gcatgtctac gagaacaatc ctaaaggaag atccagcaaa tacggtttac      660

tccactgtgg aaataccgaa aaagatggaa aatccccact cactgctcac gatgccagac      720

acaccaaggc tatttgccta tgagaatgtt atctagacag cagtgcactc ccctaagtct      780

ctgctcaaaa aaaaaacaat tctcggccca aagaaaacaa tcagaagaat tcactgattt      840

gactagaaac atcaaggaag aatgaagaac gttgactttt ttccaggata aattatctct      900

gatgcttctt tagatttaag agttcataat tccatccact gctgagaaat ctcctcaaac      960

ccagaaggtt taatcacttc atcccaaaaa tgggattgtg aatgtcagca aaccataaaa     1020

aaagtgctta gaagtattcc tataaaaatg taaatgcaag gtcacacata ttaatgacag     1080

cctgttgtat taatgatggc tccaggtcag tgtctggagt ttcattccat cccagggctt     1140

ggatgtcagg attataccaa gagtcttgct accaggaggg caagaagacc aaaacagaca     1200

gacaagtcca gcagaagcag atgcacctga caaaaatgga tgtattaatt ggctctataa     1260

actatgtgcc cagcactatg ctgagcttac actaattggt cagacatgct gtctgccctc     1320

atgaaattgg ctccaaatga atgaactact ttcatgagca gttgtagcag gcctgaccac     1380

agattcccag agggccaggt gtggatccac aggacttgaa ggtcaaagtt cacaaagatg     1440

aagaatcagg gtagctgacc atgtttggca gatactataa tggagacaca gaagtgtgca     1500

tggcccaagg acaaggacct ccagccaggc ttcatttatg cacttgtgct gcaaaagaaa     1560

agtctaggtt ttaaggctgt gccagaaccc atcccaataa agagaccgag tctgaagtca     1620

cattgtaaat ctagtgtagg agacttggag tcaggcagtg agactggtgg ggcacggggg     1680

gcagtgggta cttgtaaacc tttaaagatg gttaattcat tcaatagata tttattaaga     1740

acctatgcgg cccggcatgg tggctcacac ctgtaatccc agcactttgg gaggccaagg     1800

tgggtgggtc atctgaggtc aggagttcaa gaccagcctg gccaacatgg tgaaacccca     1860

tctctactaa agatacaaaa atttgctgag cgtggtggtg tgcacctgta atcccagcta     1920

ctcgagaggc caaggcatga gaatcgcttg aacctgggag gtggaggttg cagtgagctg     1980

agatggcacc actgcactcc ggcctaggca acgagagcaa aactccaata caaacaaaca     2040

aacaaacacc tgtgctaggt cagtctggca cgtaagatga acatccctac caatacagag     2100

ctcaccatct cttatactta agtgaaaaac atggggaagg ggaaagggga atggctgctt     2160

ttgatatgtt ccctgacaca tatcttgaat ggagacctcc ctaccaagtg atgaaagtgt     2220

tgaaaaactt aataacaaat gcttgttggg caagaatggg attgaggatt atcttctctc     2280

agaaaggcat tgtgaaggaa ttgagccaga tctctctccc tactgcaaaa ccctattgta     2340

gtaaaaaagt cttctttact atcttaataa aacagatatt gtgagattca catacaaaaa     2400

aaaaaaaaaa a                                                          2411


<210>  5
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu Tyr Ile 
        115                 120                 125             


Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys 
    130                 135                 140                 


Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn 
145                 150                 155                 160 


Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val 
                165                 170                 175     


Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro 
            180                 185                 190         


Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
        195                 200                 


<210>  6
<211>  2515
<212>  DNA
<213>  homo sapiens

<400>  6
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

ggtcagcagc ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt      360

tccccctgaa gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc      420

ctcttgtcac catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg      480

agagagtaga cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg      540

actcagggat ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg      600

agtacgtgct gcatgtctac gagtacattg aagagaagaa gagagtggac atttgtcggg      660

aaactcctaa catatgcccc cattctggag agaacacaga gtacgacaca atccctcaca      720

ctaatagaac aatcctaaag gaagatccag caaatacggt ttactccact gtggaaatac      780

cgaaaaagat ggaaaatccc cactcactgc tcacgatgcc agacacacca aggctatttg      840

cctatgagaa tgttatctag acagcagtgc actcccctaa gtctctgctc aaaaaaaaaa      900

caattctcgg cccaaagaaa acaatcagaa gaattcactg atttgactag aaacatcaag      960

gaagaatgaa gaacgttgac ttttttccag gataaattat ctctgatgct tctttagatt     1020

taagagttca taattccatc cactgctgag aaatctcctc aaacccagaa ggtttaatca     1080

cttcatccca aaaatgggat tgtgaatgtc agcaaaccat aaaaaaagtg cttagaagta     1140

ttcctataaa aatgtaaatg caaggtcaca catattaatg acagcctgtt gtattaatga     1200

tggctccagg tcagtgtctg gagtttcatt ccatcccagg gcttggatgt caggattata     1260

ccaagagtct tgctaccagg agggcaagaa gaccaaaaca gacagacaag tccagcagaa     1320

gcagatgcac ctgacaaaaa tggatgtatt aattggctct ataaactatg tgcccagcac     1380

tatgctgagc ttacactaat tggtcagaca tgctgtctgc cctcatgaaa ttggctccaa     1440

atgaatgaac tactttcatg agcagttgta gcaggcctga ccacagattc ccagagggcc     1500

aggtgtggat ccacaggact tgaaggtcaa agttcacaaa gatgaagaat cagggtagct     1560

gaccatgttt ggcagatact ataatggaga cacagaagtg tgcatggccc aaggacaagg     1620

acctccagcc aggcttcatt tatgcacttg tgctgcaaaa gaaaagtcta ggttttaagg     1680

ctgtgccaga acccatccca ataaagagac cgagtctgaa gtcacattgt aaatctagtg     1740

taggagactt ggagtcaggc agtgagactg gtggggcacg gggggcagtg ggtacttgta     1800

aacctttaaa gatggttaat tcattcaata gatatttatt aagaacctat gcggcccggc     1860

atggtggctc acacctgtaa tcccagcact ttgggaggcc aaggtgggtg ggtcatctga     1920

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaagatac     1980

aaaaatttgc tgagcgtggt ggtgtgcacc tgtaatccca gctactcgag aggccaaggc     2040

atgagaatcg cttgaacctg ggaggtggag gttgcagtga gctgagatgg caccactgca     2100

ctccggccta ggcaacgaga gcaaaactcc aatacaaaca aacaaacaaa cacctgtgct     2160

aggtcagtct ggcacgtaag atgaacatcc ctaccaatac agagctcacc atctcttata     2220

cttaagtgaa aaacatgggg aaggggaaag gggaatggct gcttttgata tgttccctga     2280

cacatatctt gaatggagac ctccctacca agtgatgaaa gtgttgaaaa acttaataac     2340

aaatgcttgt tgggcaagaa tgggattgag gattatcttc tctcagaaag gcattgtgaa     2400

ggaattgagc cagatctctc tccctactgc aaaaccctat tgtagtaaaa aagtcttctt     2460

tactatctta ataaaacaga tattgtgaga ttcacataca aaaaaaaaaa aaaaa          2515


<210>  7
<211>  228
<212>  PRT
<213>  homo sapiens

<400>  7

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser 
            20                  25                  30          


Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His 
        35                  40                  45              


Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala 
    50                  55                  60                  


Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly 
65                  70                  75                  80  


Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg 
                85                  90                  95      


Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala 
            100                 105                 110         


Asp Asp Pro Asp Ser Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro 
        115                 120                 125             


Leu Leu Leu Ser Leu Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys 
    130                 135                 140                 


Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile 
145                 150                 155                 160 


Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu 
                165                 170                 175     


Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro 
            180                 185                 190         


Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn 
        195                 200                 205             


Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr 
    210                 215                 220                 


Glu Asn Val Ile 
225             


<210>  8
<211>  2587
<212>  DNA
<213>  homo sapiens

<400>  8
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

agcacctgtc aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg      360

tgaccaatct gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg      420

ccctggggca agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat      480

ggggagaaag tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct      540

caagccccat ccttgccagg aagctctgtg aaggtgctgc tgatgaccca gattcctcca      600

tggtcctcct gtgtctcctg ttggtgcccc tcctgctcag tctctttgta ctggggctat      660

ttctttggtt tctgaagaga gagagacaag aagagtacat tgaagagaag aagagagtgg      720

acatttgtcg ggaaactcct aacatatgcc cccattctgg agagaacaca gagtacgaca      780

caatccctca cactaataga acaatcctaa aggaagatcc agcaaatacg gtttactcca      840

ctgtggaaat accgaaaaag atggaaaatc cccactcact gctcacgatg ccagacacac      900

caaggctatt tgcctatgag aatgttatct agacagcagt gcactcccct aagtctctgc      960

tcaaaaaaaa aacaattctc ggcccaaaga aaacaatcag aagaattcac tgatttgact     1020

agaaacatca aggaagaatg aagaacgttg acttttttcc aggataaatt atctctgatg     1080

cttctttaga tttaagagtt cataattcca tccactgctg agaaatctcc tcaaacccag     1140

aaggtttaat cacttcatcc caaaaatggg attgtgaatg tcagcaaacc ataaaaaaag     1200

tgcttagaag tattcctata aaaatgtaaa tgcaaggtca cacatattaa tgacagcctg     1260

ttgtattaat gatggctcca ggtcagtgtc tggagtttca ttccatccca gggcttggat     1320

gtcaggatta taccaagagt cttgctacca ggagggcaag aagaccaaaa cagacagaca     1380

agtccagcag aagcagatgc acctgacaaa aatggatgta ttaattggct ctataaacta     1440

tgtgcccagc actatgctga gcttacacta attggtcaga catgctgtct gccctcatga     1500

aattggctcc aaatgaatga actactttca tgagcagttg tagcaggcct gaccacagat     1560

tcccagaggg ccaggtgtgg atccacagga cttgaaggtc aaagttcaca aagatgaaga     1620

atcagggtag ctgaccatgt ttggcagata ctataatgga gacacagaag tgtgcatggc     1680

ccaaggacaa ggacctccag ccaggcttca tttatgcact tgtgctgcaa aagaaaagtc     1740

taggttttaa ggctgtgcca gaacccatcc caataaagag accgagtctg aagtcacatt     1800

gtaaatctag tgtaggagac ttggagtcag gcagtgagac tggtggggca cggggggcag     1860

tgggtacttg taaaccttta aagatggtta attcattcaa tagatattta ttaagaacct     1920

atgcggcccg gcatggtggc tcacacctgt aatcccagca ctttgggagg ccaaggtggg     1980

tgggtcatct gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc     2040

tactaaagat acaaaaattt gctgagcgtg gtggtgtgca cctgtaatcc cagctactcg     2100

agaggccaag gcatgagaat cgcttgaacc tgggaggtgg aggttgcagt gagctgagat     2160

ggcaccactg cactccggcc taggcaacga gagcaaaact ccaatacaaa caaacaaaca     2220

aacacctgtg ctaggtcagt ctggcacgta agatgaacat ccctaccaat acagagctca     2280

ccatctctta tacttaagtg aaaaacatgg ggaaggggaa aggggaatgg ctgcttttga     2340

tatgttccct gacacatatc ttgaatggag acctccctac caagtgatga aagtgttgaa     2400

aaacttaata acaaatgctt gttgggcaag aatgggattg aggattatct tctctcagaa     2460

aggcattgtg aaggaattga gccagatctc tctccctact gcaaaaccct attgtagtaa     2520

aaaagtcttc tttactatct taataaaaca gatattgtga gattcacata caaaaaaaaa     2580

aaaaaaa                                                               2587


<210>  9
<211>  188
<212>  PRT
<213>  homo sapiens

<400>  9

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser 
            20                  25                  30          


Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His 
        35                  40                  45              


Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala 
    50                  55                  60                  


Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly 
65                  70                  75                  80  


Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg 
                85                  90                  95      


Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Glu Tyr Ile 
            100                 105                 110         


Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys 
        115                 120                 125             


Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn 
    130                 135                 140                 


Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val 
145                 150                 155                 160 


Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro 
                165                 170                 175     


Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
            180                 185             


<210>  10
<211>  2467
<212>  DNA
<213>  homo sapiens

<400>  10
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

agcacctgtc aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg      360

tgaccaatct gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg      420

ccctggggca agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat      480

ggggagaaag tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct      540

caagccccat ccttgccagg aagctctgtg aagagtacat tgaagagaag aagagagtgg      600

acatttgtcg ggaaactcct aacatatgcc cccattctgg agagaacaca gagtacgaca      660

caatccctca cactaataga acaatcctaa aggaagatcc agcaaatacg gtttactcca      720

ctgtggaaat accgaaaaag atggaaaatc cccactcact gctcacgatg ccagacacac      780

caaggctatt tgcctatgag aatgttatct agacagcagt gcactcccct aagtctctgc      840

tcaaaaaaaa aacaattctc ggcccaaaga aaacaatcag aagaattcac tgatttgact      900

agaaacatca aggaagaatg aagaacgttg acttttttcc aggataaatt atctctgatg      960

cttctttaga tttaagagtt cataattcca tccactgctg agaaatctcc tcaaacccag     1020

aaggtttaat cacttcatcc caaaaatggg attgtgaatg tcagcaaacc ataaaaaaag     1080

tgcttagaag tattcctata aaaatgtaaa tgcaaggtca cacatattaa tgacagcctg     1140

ttgtattaat gatggctcca ggtcagtgtc tggagtttca ttccatccca gggcttggat     1200

gtcaggatta taccaagagt cttgctacca ggagggcaag aagaccaaaa cagacagaca     1260

agtccagcag aagcagatgc acctgacaaa aatggatgta ttaattggct ctataaacta     1320

tgtgcccagc actatgctga gcttacacta attggtcaga catgctgtct gccctcatga     1380

aattggctcc aaatgaatga actactttca tgagcagttg tagcaggcct gaccacagat     1440

tcccagaggg ccaggtgtgg atccacagga cttgaaggtc aaagttcaca aagatgaaga     1500

atcagggtag ctgaccatgt ttggcagata ctataatgga gacacagaag tgtgcatggc     1560

ccaaggacaa ggacctccag ccaggcttca tttatgcact tgtgctgcaa aagaaaagtc     1620

taggttttaa ggctgtgcca gaacccatcc caataaagag accgagtctg aagtcacatt     1680

gtaaatctag tgtaggagac ttggagtcag gcagtgagac tggtggggca cggggggcag     1740

tgggtacttg taaaccttta aagatggtta attcattcaa tagatattta ttaagaacct     1800

atgcggcccg gcatggtggc tcacacctgt aatcccagca ctttgggagg ccaaggtggg     1860

tgggtcatct gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc     1920

tactaaagat acaaaaattt gctgagcgtg gtggtgtgca cctgtaatcc cagctactcg     1980

agaggccaag gcatgagaat cgcttgaacc tgggaggtgg aggttgcagt gagctgagat     2040

ggcaccactg cactccggcc taggcaacga gagcaaaact ccaatacaaa caaacaaaca     2100

aacacctgtg ctaggtcagt ctggcacgta agatgaacat ccctaccaat acagagctca     2160

ccatctctta tacttaagtg aaaaacatgg ggaaggggaa aggggaatgg ctgcttttga     2220

tatgttccct gacacatatc ttgaatggag acctccctac caagtgatga aagtgttgaa     2280

aaacttaata acaaatgctt gttgggcaag aatgggattg aggattatct tctctcagaa     2340

aggcattgtg aaggaattga gccagatctc tctccctact gcaaaaccct attgtagtaa     2400

aaaagtcttc tttactatct taataaaaca gatattgtga gattcacata caaaaaaaaa     2460

aaaaaaa                                                               2467


<210>  11
<211>  296
<212>  PRT
<213>  homo sapiens

<400>  11

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Asn Asn Pro Lys Gly Arg Ser Ser Lys Tyr Gly Leu Leu His Cys 
            260                 265                 270         


Gly Asn Thr Glu Lys Asp Gly Lys Ser Pro Leu Thr Ala His Asp Ala 
        275                 280                 285             


Arg His Thr Lys Ala Ile Cys Leu 
    290                 295     


<210>  12
<211>  2804
<212>  DNA
<213>  homo sapiens

<400>  12
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

ggtcagcagc ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt      360

tccccctgaa gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc      420

ctcttgtcac catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg      480

agagagtaga cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg      540

actcagggat ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg      600

agtacgtgct gcatgtctac gagcacctgt caaagcctaa agtcaccatg ggtctgcaga      660

gcaataagaa tggcacctgt gtgaccaatc tgacatgctg catggaacat ggggaagagg      720

atgtgattta tacctggaag gccctggggc aagcagccaa tgagtcccat aatgggtcca      780

tcctccccat ctcctggaga tggggagaaa gtgatatgac cttcatctgc gttgccagga      840

accctgtcag cagaaacttc tcaagcccca tccttgccag gaagctctgt gaaggtgctg      900

ctgatgaccc agattcctcc atggtcctcc tgtgtctcct gttggtgccc ctcctgctca      960

gtctctttgt actggggcta tttctttggt ttctgaagag agagagacaa gaagagaaca     1020

atcctaaagg aagatccagc aaatacggtt tactccactg tggaaatacc gaaaaagatg     1080

gaaaatcccc actcactgct cacgatgcca gacacaccaa ggctatttgc ctatgagaat     1140

gttatctaga cagcagtgca ctcccctaag tctctgctca aaaaaaaaac aattctcggc     1200

ccaaagaaaa caatcagaag aattcactga tttgactaga aacatcaagg aagaatgaag     1260

aacgttgact tttttccagg ataaattatc tctgatgctt ctttagattt aagagttcat     1320

aattccatcc actgctgaga aatctcctca aacccagaag gtttaatcac ttcatcccaa     1380

aaatgggatt gtgaatgtca gcaaaccata aaaaaagtgc ttagaagtat tcctataaaa     1440

atgtaaatgc aaggtcacac atattaatga cagcctgttg tattaatgat ggctccaggt     1500

cagtgtctgg agtttcattc catcccaggg cttggatgtc aggattatac caagagtctt     1560

gctaccagga gggcaagaag accaaaacag acagacaagt ccagcagaag cagatgcacc     1620

tgacaaaaat ggatgtatta attggctcta taaactatgt gcccagcact atgctgagct     1680

tacactaatt ggtcagacat gctgtctgcc ctcatgaaat tggctccaaa tgaatgaact     1740

actttcatga gcagttgtag caggcctgac cacagattcc cagagggcca ggtgtggatc     1800

cacaggactt gaaggtcaaa gttcacaaag atgaagaatc agggtagctg accatgtttg     1860

gcagatacta taatggagac acagaagtgt gcatggccca aggacaagga cctccagcca     1920

ggcttcattt atgcacttgt gctgcaaaag aaaagtctag gttttaaggc tgtgccagaa     1980

cccatcccaa taaagagacc gagtctgaag tcacattgta aatctagtgt aggagacttg     2040

gagtcaggca gtgagactgg tggggcacgg ggggcagtgg gtacttgtaa acctttaaag     2100

atggttaatt cattcaatag atatttatta agaacctatg cggcccggca tggtggctca     2160

cacctgtaat cccagcactt tgggaggcca aggtgggtgg gtcatctgag gtcaggagtt     2220

caagaccagc ctggccaaca tggtgaaacc ccatctctac taaagataca aaaatttgct     2280

gagcgtggtg gtgtgcacct gtaatcccag ctactcgaga ggccaaggca tgagaatcgc     2340

ttgaacctgg gaggtggagg ttgcagtgag ctgagatggc accactgcac tccggcctag     2400

gcaacgagag caaaactcca atacaaacaa acaaacaaac acctgtgcta ggtcagtctg     2460

gcacgtaaga tgaacatccc taccaataca gagctcacca tctcttatac ttaagtgaaa     2520

aacatgggga aggggaaagg ggaatggctg cttttgatat gttccctgac acatatcttg     2580

aatggagacc tccctaccaa gtgatgaaag tgttgaaaaa cttaataaca aatgcttgtt     2640

gggcaagaat gggattgagg attatcttct ctcagaaagg cattgtgaag gaattgagcc     2700

agatctctct ccctactgca aaaccctatt gtagtaaaaa agtcttcttt actatcttaa     2760

taaaacagat attgtgagat tcacatacaa aaaaaaaaaa aaaa                      2804


<210>  13
<211>  149
<212>  PRT
<213>  homo sapiens

<400>  13

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser 
            20                  25                  30          


Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His 
        35                  40                  45              


Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala 
    50                  55                  60                  


Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly 
65                  70                  75                  80  


Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg 
                85                  90                  95      


Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Glu Asn Asn 
            100                 105                 110         


Pro Lys Gly Arg Ser Ser Lys Tyr Gly Leu Leu His Cys Gly Asn Thr 
        115                 120                 125             


Glu Lys Asp Gly Lys Ser Pro Leu Thr Ala His Asp Ala Arg His Thr 
    130                 135                 140                 


Lys Ala Ile Cys Leu 
145                 


<210>  14
<211>  2363
<212>  DNA
<213>  homo sapiens

<400>  14
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

agcacctgtc aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg      360

tgaccaatct gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg      420

ccctggggca agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat      480

ggggagaaag tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct      540

caagccccat ccttgccagg aagctctgtg aagagaacaa tcctaaagga agatccagca      600

aatacggttt actccactgt ggaaataccg aaaaagatgg aaaatcccca ctcactgctc      660

acgatgccag acacaccaag gctatttgcc tatgagaatg ttatctagac agcagtgcac      720

tcccctaagt ctctgctcaa aaaaaaaaca attctcggcc caaagaaaac aatcagaaga      780

attcactgat ttgactagaa acatcaagga agaatgaaga acgttgactt ttttccagga      840

taaattatct ctgatgcttc tttagattta agagttcata attccatcca ctgctgagaa      900

atctcctcaa acccagaagg tttaatcact tcatcccaaa aatgggattg tgaatgtcag      960

caaaccataa aaaaagtgct tagaagtatt cctataaaaa tgtaaatgca aggtcacaca     1020

tattaatgac agcctgttgt attaatgatg gctccaggtc agtgtctgga gtttcattcc     1080

atcccagggc ttggatgtca ggattatacc aagagtcttg ctaccaggag ggcaagaaga     1140

ccaaaacaga cagacaagtc cagcagaagc agatgcacct gacaaaaatg gatgtattaa     1200

ttggctctat aaactatgtg cccagcacta tgctgagctt acactaattg gtcagacatg     1260

ctgtctgccc tcatgaaatt ggctccaaat gaatgaacta ctttcatgag cagttgtagc     1320

aggcctgacc acagattccc agagggccag gtgtggatcc acaggacttg aaggtcaaag     1380

ttcacaaaga tgaagaatca gggtagctga ccatgtttgg cagatactat aatggagaca     1440

cagaagtgtg catggcccaa ggacaaggac ctccagccag gcttcattta tgcacttgtg     1500

ctgcaaaaga aaagtctagg ttttaaggct gtgccagaac ccatcccaat aaagagaccg     1560

agtctgaagt cacattgtaa atctagtgta ggagacttgg agtcaggcag tgagactggt     1620

ggggcacggg gggcagtggg tacttgtaaa cctttaaaga tggttaattc attcaataga     1680

tatttattaa gaacctatgc ggcccggcat ggtggctcac acctgtaatc ccagcacttt     1740

gggaggccaa ggtgggtggg tcatctgagg tcaggagttc aagaccagcc tggccaacat     1800

ggtgaaaccc catctctact aaagatacaa aaatttgctg agcgtggtgg tgtgcacctg     1860

taatcccagc tactcgagag gccaaggcat gagaatcgct tgaacctggg aggtggaggt     1920

tgcagtgagc tgagatggca ccactgcact ccggcctagg caacgagagc aaaactccaa     1980

tacaaacaaa caaacaaaca cctgtgctag gtcagtctgg cacgtaagat gaacatccct     2040

accaatacag agctcaccat ctcttatact taagtgaaaa acatggggaa ggggaaaggg     2100

gaatggctgc ttttgatatg ttccctgaca catatcttga atggagacct ccctaccaag     2160

tgatgaaagt gttgaaaaac ttaataacaa atgcttgttg ggcaagaatg ggattgagga     2220

ttatcttctc tcagaaaggc attgtgaagg aattgagcca gatctctctc cctactgcaa     2280

aaccctattg tagtaaaaaa gtcttcttta ctatcttaat aaaacagata ttgtgagatt     2340

cacatacaaa aaaaaaaaaa aaa                                             2363


<210>  15
<211>  241
<212>  PRT
<213>  homo sapiens

<400>  15

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser 
            20                  25                  30          


Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His 
        35                  40                  45              


Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala 
    50                  55                  60                  


Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly 
65                  70                  75                  80  


Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg 
                85                  90                  95      


Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Gly Asp Cys 
            100                 105                 110         


Leu Ser Pro Leu His Arg Arg Leu Cys Pro Gly Ala Ala Asp Asp Pro 
        115                 120                 125             


Asp Ser Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu 
    130                 135                 140                 


Ser Leu Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg 
145                 150                 155                 160 


Gln Glu Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu 
                165                 170                 175     


Thr Pro Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr 
            180                 185                 190         


Ile Pro His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr 
        195                 200                 205             


Val Tyr Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser 
    210                 215                 220                 


Leu Leu Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val 
225                 230                 235                 240 


Ile 
    


<210>  16
<211>  2626
<212>  DNA
<213>  homo sapiens

<400>  16
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

agcacctgtc aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg      360

tgaccaatct gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg      420

ccctggggca agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat      480

ggggagaaag tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct      540

caagccccat ccttgccagg aagctctgtg aaggtgactg cctctcccct ctccacagga      600

gactctgccc aggtgctgct gatgacccag attcctccat ggtcctcctg tgtctcctgt      660

tggtgcccct cctgctcagt ctctttgtac tggggctatt tctttggttt ctgaagagag      720

agagacaaga agagtacatt gaagagaaga agagagtgga catttgtcgg gaaactccta      780

acatatgccc ccattctgga gagaacacag agtacgacac aatccctcac actaatagaa      840

caatcctaaa ggaagatcca gcaaatacgg tttactccac tgtggaaata ccgaaaaaga      900

tggaaaatcc ccactcactg ctcacgatgc cagacacacc aaggctattt gcctatgaga      960

atgttatcta gacagcagtg cactccccta agtctctgct caaaaaaaaa acaattctcg     1020

gcccaaagaa aacaatcaga agaattcact gatttgacta gaaacatcaa ggaagaatga     1080

agaacgttga cttttttcca ggataaatta tctctgatgc ttctttagat ttaagagttc     1140

ataattccat ccactgctga gaaatctcct caaacccaga aggtttaatc acttcatccc     1200

aaaaatggga ttgtgaatgt cagcaaacca taaaaaaagt gcttagaagt attcctataa     1260

aaatgtaaat gcaaggtcac acatattaat gacagcctgt tgtattaatg atggctccag     1320

gtcagtgtct ggagtttcat tccatcccag ggcttggatg tcaggattat accaagagtc     1380

ttgctaccag gagggcaaga agaccaaaac agacagacaa gtccagcaga agcagatgca     1440

cctgacaaaa atggatgtat taattggctc tataaactat gtgcccagca ctatgctgag     1500

cttacactaa ttggtcagac atgctgtctg ccctcatgaa attggctcca aatgaatgaa     1560

ctactttcat gagcagttgt agcaggcctg accacagatt cccagagggc caggtgtgga     1620

tccacaggac ttgaaggtca aagttcacaa agatgaagaa tcagggtagc tgaccatgtt     1680

tggcagatac tataatggag acacagaagt gtgcatggcc caaggacaag gacctccagc     1740

caggcttcat ttatgcactt gtgctgcaaa agaaaagtct aggttttaag gctgtgccag     1800

aacccatccc aataaagaga ccgagtctga agtcacattg taaatctagt gtaggagact     1860

tggagtcagg cagtgagact ggtggggcac ggggggcagt gggtacttgt aaacctttaa     1920

agatggttaa ttcattcaat agatatttat taagaaccta tgcggcccgg catggtggct     1980

cacacctgta atcccagcac tttgggaggc caaggtgggt gggtcatctg aggtcaggag     2040

ttcaagacca gcctggccaa catggtgaaa ccccatctct actaaagata caaaaatttg     2100

ctgagcgtgg tggtgtgcac ctgtaatccc agctactcga gaggccaagg catgagaatc     2160

gcttgaacct gggaggtgga ggttgcagtg agctgagatg gcaccactgc actccggcct     2220

aggcaacgag agcaaaactc caatacaaac aaacaaacaa acacctgtgc taggtcagtc     2280

tggcacgtaa gatgaacatc cctaccaata cagagctcac catctcttat acttaagtga     2340

aaaacatggg gaaggggaaa ggggaatggc tgcttttgat atgttccctg acacatatct     2400

tgaatggaga cctccctacc aagtgatgaa agtgttgaaa aacttaataa caaatgcttg     2460

ttgggcaaga atgggattga ggattatctt ctctcagaaa ggcattgtga aggaattgag     2520

ccagatctct ctccctactg caaaacccta ttgtagtaaa aaagtcttct ttactatctt     2580

aataaaacag atattgtgag attcacatac aaaaaaaaaa aaaaaa                    2626


<210>  17
<211>  201
<212>  PRT
<213>  homo sapiens

<400>  17

Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr 
1               5                   10                  15      


Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala 
            20                  25                  30          


Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile 
        35                  40                  45              


Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg 
    50                  55                  60                  


Asn Pro Val Ser Arg Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu 
65                  70                  75                  80  


Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser Ser Met Val Leu Leu Cys 
                85                  90                  95      


Leu Leu Leu Val Pro Leu Leu Leu Ser Leu Phe Val Leu Gly Leu Phe 
            100                 105                 110         


Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys 
        115                 120                 125             


Lys Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser 
    130                 135                 140                 


Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile 
145                 150                 155                 160 


Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro 
                165                 170                 175     


Lys Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro 
            180                 185                 190         


Arg Leu Phe Ala Tyr Glu Asn Val Ile 
        195                 200     


<210>  18
<211>  2369
<212>  DNA
<213>  homo sapiens

<400>  18
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca agagcacctg tcaaagccta aagtcaccat gggtctgcag      120

agcaataaga atggcacctg tgtgaccaat ctgacatgct gcatggaaca tggggaagag      180

gatgtgattt atacctggaa ggccctgggg caagcagcca atgagtccca taatgggtcc      240

atcctcccca tctcctggag atggggagaa agtgatatga ccttcatctg cgttgccagg      300

aaccctgtca gcagaaactt ctcaagcccc atccttgcca ggaagctctg tgaaggtgct      360

gctgatgacc cagattcctc catggtcctc ctgtgtctcc tgttggtgcc cctcctgctc      420

agtctctttg tactggggct atttctttgg tttctgaaga gagagagaca agaagagtac      480

attgaagaga agaagagagt ggacatttgt cgggaaactc ctaacatatg cccccattct      540

ggagagaaca cagagtacga cacaatccct cacactaata gaacaatcct aaaggaagat      600

ccagcaaata cggtttactc cactgtggaa ataccgaaaa agatggaaaa tccccactca      660

ctgctcacga tgccagacac accaaggcta tttgcctatg agaatgttat ctagacagca      720

gtgcactccc ctaagtctct gctcaaaaaa aaaacaattc tcggcccaaa gaaaacaatc      780

agaagaattc actgatttga ctagaaacat caaggaagaa tgaagaacgt tgactttttt      840

ccaggataaa ttatctctga tgcttcttta gatttaagag ttcataattc catccactgc      900

tgagaaatct cctcaaaccc agaaggttta atcacttcat cccaaaaatg ggattgtgaa      960

tgtcagcaaa ccataaaaaa agtgcttaga agtattccta taaaaatgta aatgcaaggt     1020

cacacatatt aatgacagcc tgttgtatta atgatggctc caggtcagtg tctggagttt     1080

cattccatcc cagggcttgg atgtcaggat tataccaaga gtcttgctac caggagggca     1140

agaagaccaa aacagacaga caagtccagc agaagcagat gcacctgaca aaaatggatg     1200

tattaattgg ctctataaac tatgtgccca gcactatgct gagcttacac taattggtca     1260

gacatgctgt ctgccctcat gaaattggct ccaaatgaat gaactacttt catgagcagt     1320

tgtagcaggc ctgaccacag attcccagag ggccaggtgt ggatccacag gacttgaagg     1380

tcaaagttca caaagatgaa gaatcagggt agctgaccat gtttggcaga tactataatg     1440

gagacacaga agtgtgcatg gcccaaggac aaggacctcc agccaggctt catttatgca     1500

cttgtgctgc aaaagaaaag tctaggtttt aaggctgtgc cagaacccat cccaataaag     1560

agaccgagtc tgaagtcaca ttgtaaatct agtgtaggag acttggagtc aggcagtgag     1620

actggtgggg cacggggggc agtgggtact tgtaaacctt taaagatggt taattcattc     1680

aatagatatt tattaagaac ctatgcggcc cggcatggtg gctcacacct gtaatcccag     1740

cactttggga ggccaaggtg ggtgggtcat ctgaggtcag gagttcaaga ccagcctggc     1800

caacatggtg aaaccccatc tctactaaag atacaaaaat ttgctgagcg tggtggtgtg     1860

cacctgtaat cccagctact cgagaggcca aggcatgaga atcgcttgaa cctgggaggt     1920

ggaggttgca gtgagctgag atggcaccac tgcactccgg cctaggcaac gagagcaaaa     1980

ctccaataca aacaaacaaa caaacacctg tgctaggtca gtctggcacg taagatgaac     2040

atccctacca atacagagct caccatctct tatacttaag tgaaaaacat ggggaagggg     2100

aaaggggaat ggctgctttt gatatgttcc ctgacacata tcttgaatgg agacctccct     2160

accaagtgat gaaagtgttg aaaaacttaa taacaaatgc ttgttgggca agaatgggat     2220

tgaggattat cttctctcag aaaggcattg tgaaggaatt gagccagatc tctctcccta     2280

ctgcaaaacc ctattgtagt aaaaaagtct tctttactat cttaataaaa cagatattgt     2340

gagattcaca tacaaaaaaa aaaaaaaaa                                       2369


<210>  19
<211>  189
<212>  PRT
<213>  homo sapiens

<400>  19

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser 
            20                  25                  30          


Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His 
        35                  40                  45              


Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala 
    50                  55                  60                  


Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly 
65                  70                  75                  80  


Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg 
                85                  90                  95      


Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala 
            100                 105                 110         


Asp Asp Pro Asp Ser Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro 
        115                 120                 125             


Leu Leu Leu Ser Leu Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys 
    130                 135                 140                 


Arg Glu Arg Gln Glu Glu Asn Asn Pro Lys Gly Arg Ser Ser Lys Tyr 
145                 150                 155                 160 


Gly Leu Leu His Cys Gly Asn Thr Glu Lys Asp Gly Lys Ser Pro Leu 
                165                 170                 175     


Thr Ala His Asp Ala Arg His Thr Lys Ala Ile Cys Leu 
            180                 185                 


<210>  20
<211>  2483
<212>  DNA
<213>  homo sapiens

<400>  20
agctaaaata taaaatggga atataccaaa tgctgatgaa gatggggagc aaatagatct       60

ctcatagatt gctggtggca aggtaaaatg ctctattcac tctgaaaata atttagcaat      120

tactcaatct cacatgtctg cggcgtgacc cctcctgctt ctttaaatat cagctgggga      180

agaggtctga gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga      240

gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag      300

agcacctgtc aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg      360

tgaccaatct gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg      420

ccctggggca agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat      480

ggggagaaag tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct      540

caagccccat ccttgccagg aagctctgtg aaggtgctgc tgatgaccca gattcctcca      600

tggtcctcct gtgtctcctg ttggtgcccc tcctgctcag tctctttgta ctggggctat      660

ttctttggtt tctgaagaga gagagacaag aagagaacaa tcctaaagga agatccagca      720

aatacggttt actccactgt ggaaataccg aaaaagatgg aaaatcccca ctcactgctc      780

acgatgccag acacaccaag gctatttgcc tatgagaatg ttatctagac agcagtgcac      840

tcccctaagt ctctgctcaa aaaaaaaaca attctcggcc caaagaaaac aatcagaaga      900

attcactgat ttgactagaa acatcaagga agaatgaaga acgttgactt ttttccagga      960

taaattatct ctgatgcttc tttagattta agagttcata attccatcca ctgctgagaa     1020

atctcctcaa acccagaagg tttaatcact tcatcccaaa aatgggattg tgaatgtcag     1080

caaaccataa aaaaagtgct tagaagtatt cctataaaaa tgtaaatgca aggtcacaca     1140

tattaatgac agcctgttgt attaatgatg gctccaggtc agtgtctgga gtttcattcc     1200

atcccagggc ttggatgtca ggattatacc aagagtcttg ctaccaggag ggcaagaaga     1260

ccaaaacaga cagacaagtc cagcagaagc agatgcacct gacaaaaatg gatgtattaa     1320

ttggctctat aaactatgtg cccagcacta tgctgagctt acactaattg gtcagacatg     1380

ctgtctgccc tcatgaaatt ggctccaaat gaatgaacta ctttcatgag cagttgtagc     1440

aggcctgacc acagattccc agagggccag gtgtggatcc acaggacttg aaggtcaaag     1500

ttcacaaaga tgaagaatca gggtagctga ccatgtttgg cagatactat aatggagaca     1560

cagaagtgtg catggcccaa ggacaaggac ctccagccag gcttcattta tgcacttgtg     1620

ctgcaaaaga aaagtctagg ttttaaggct gtgccagaac ccatcccaat aaagagaccg     1680

agtctgaagt cacattgtaa atctagtgta ggagacttgg agtcaggcag tgagactggt     1740

ggggcacggg gggcagtggg tacttgtaaa cctttaaaga tggttaattc attcaataga     1800

tatttattaa gaacctatgc ggcccggcat ggtggctcac acctgtaatc ccagcacttt     1860

gggaggccaa ggtgggtggg tcatctgagg tcaggagttc aagaccagcc tggccaacat     1920

ggtgaaaccc catctctact aaagatacaa aaatttgctg agcgtggtgg tgtgcacctg     1980

taatcccagc tactcgagag gccaaggcat gagaatcgct tgaacctggg aggtggaggt     2040

tgcagtgagc tgagatggca ccactgcact ccggcctagg caacgagagc aaaactccaa     2100

tacaaacaaa caaacaaaca cctgtgctag gtcagtctgg cacgtaagat gaacatccct     2160

accaatacag agctcaccat ctcttatact taagtgaaaa acatggggaa ggggaaaggg     2220

gaatggctgc ttttgatatg ttccctgaca catatcttga atggagacct ccctaccaag     2280

tgatgaaagt gttgaaaaac ttaataacaa atgcttgttg ggcaagaatg ggattgagga     2340

ttatcttctc tcagaaaggc attgtgaagg aattgagcca gatctctctc cctactgcaa     2400

aaccctattg tagtaaaaaa gtcttcttta ctatcttaat aaaacagata ttgtgagatt     2460

cacatacaaa aaaaaaaaaa aaa                                             2483


<210>  21
<211>  305
<212>  PRT
<213>  homo sapiens

<400>  21

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 


<210>  22
<211>  323
<212>  PRT
<213>  homo sapiens

<400>  22

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  23
<211>  305
<212>  PRT
<213>  homo sapiens

<400>  23

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24
caccgagcaa cagcgccgcc gccaa                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25
caccgttggc ggcggcgctg ttgct                                             25


