                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER

<130>  UM-36350/WO-1/ORD

<150>  US 62/657,055
<151>  2018-04-13

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  1
agggagaacg acgaacgtcg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  2
ggaatgacga ctgcgtgaac                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  3
aacacttaat atcccgatgc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  4
caaatcaaac tagcagattt                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  5
ggctctataa ctctgaagag                                                   20


<210>  6
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val 
1               5                   10                  15      


Tyr Lys Ala Lys Asp Lys Asp Thr Gly Glu Leu Val Ala Leu Lys Lys 
            20                  25                  30          


Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg 
        35                  40                  45              


Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg Ser Val Val Asn Met 
    50                  55                  60                  


Lys Glu Ile Val Thr Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
65                  70                  75                  80  


Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Ser Gly Leu Val 
                85                  90                  95      


His Phe Ser Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu 
            100                 105                 110         


Gly Leu Glu Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys 
        115                 120                 125             


Cys Ser Asn Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr 
145                 150                 155                 160 


Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly 
                165                 170                 175     


Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile 
            180                 185                 190         


Leu Gly Glu Leu Phe Thr Lys 
        195                 


<210>  7
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val 
1               5                   10                  15      


Tyr Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys 
            20                  25                  30          


Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg 
        35                  40                  45              


Glu Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met 
    50                  55                  60                  


Lys Glu Ile Val Thr Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
65                  70                  75                  80  


Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Ser Gly Leu Val 
                85                  90                  95      


His Phe Asn Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met Glu 
            100                 105                 110         


Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys 
        115                 120                 125             


Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr Thr 
145                 150                 155                 160 


Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly 
                165                 170                 175     


Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile 
            180                 185                 190         


Leu Gly Glu Leu Phe Thr Lys 
        195                 


<210>  8
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Tyr Glu Lys Leu Ala Lys Ile Gly Gln Gly Thr Phe Gly Glu Val 
1               5                   10                  15      


Phe Lys Ala Arg His Arg Lys Thr Gly Gln Lys Val Ala Leu Lys Lys 
            20                  25                  30          


Val Leu Met Glu Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Leu Arg 
        35                  40                  45              


Glu Ile Lys Ile Leu Gln Leu Leu Lys His Glu Asn Val Val Asn Leu 
    50                  55                  60                  


Ile Glu Ile Cys Arg Tyr Asn Arg Cys Lys Gly Ser Ile Tyr Leu Val 
65                  70                  75                  80  


Phe Asp Phe Cys Glu His Asp Leu Ala Gly Leu Leu Ser Asn Val Leu 
                85                  90                  95      


Val Lys Phe Thr Leu Ser Glu Ile Lys Arg Val Met Gln Met Leu Leu 
            100                 105                 110         


Asn Gly Leu Tyr Tyr Ile His Arg Asn Lys Ile Leu His Arg Asp Met 
        115                 120                 125             


Lys Ala Ala Asn Val Leu Ile Thr Arg Asp Gly Val Leu Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Ser Gln Pro Asn Arg Tyr Thr Asn 
145                 150                 155                 160 


Arg Val Val Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu 
                165                 170                 175     


Arg Asp Tyr Gly Pro Pro Ile Asp Leu Trp Gly Ala Gly Cys Ile Met 
            180                 185                 190         


Ala Glu Met Trp Thr Arg 
        195             


<210>  9
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val Val 
1               5                   10                  15      


Tyr Lys Ala Lys Asn Arg Glu Thr Gly Gln Leu Val Ala Leu Lys Lys 
            20                  25                  30          


Ile Arg Leu Asp Leu Glu Met Glu Gly Val Pro Ser Thr Ala Ile Arg 
        35                  40                  45              


Glu Ile Ser Leu Leu Lys Glu Leu Lys His Pro Asn Ile Val Arg Leu 
    50                  55                  60                  


Leu Asp Val Val His Asn Glu Arg Lys Leu Tyr Leu Val Phe Glu Phe 
65                  70                  75                  80  


Leu Ser Gln Asp Leu Lys Lys Tyr Met Asp Ser Thr Pro Gly Ser Glu 
                85                  90                  95      


Leu Pro Leu His Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu Gln Gly 
            100                 105                 110         


Val Ser Phe Cys His Ser His Arg Val Ile His Arg Asp Leu Lys Pro 
        115                 120                 125             


Gln Asn Leu Leu Ile Asn Glu Leu Gly Ala Ile Lys Leu Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Ala Phe Gly Val Pro Leu Arg Thr Tyr Thr His Glu 
145                 150                 155                 160 


Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly Ser Lys 
                165                 170                 175     


Phe Tyr Thr Thr Ala Val Asp Ile Trp Ser Ile Gly Cys Ile Phe Ala 
            180                 185                 190         


Glu Met Val Thr Arg 
        195         


<210>  10
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val Val 
1               5                   10                  15      


Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu Lys Lys 
            20                  25                  30          


Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala Ile Arg 
        35                  40                  45              


Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val Lys Leu 
    50                  55                  60                  


Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe Glu Phe 
65                  70                  75                  80  


Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu Thr Gly 
                85                  90                  95      


Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu Lys Pro 
        115                 120                 125             


Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr His Glu 
145                 150                 155                 160 


Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly Cys Lys 
                165                 170                 175     


Tyr Tyr Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile Phe Ala 
            180                 185                 190         


Glu Met Val Thr Arg 
        195         


<210>  11
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val Val 
1               5                   10                  15      


Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met Lys Lys 
            20                  25                  30          


Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala Ile Arg 
        35                  40                  45              


Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val Ser Leu 
    50                  55                  60                  


Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe Glu Phe 
65                  70                  75                  80  


Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro Gly Gln 
                85                  90                  95      


Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile Leu Gln 
            100                 105                 110         


Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr Thr His 
145                 150                 155                 160 


Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu Gly Ser 
                165                 170                 175     


Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Thr Lys 
        195             


<210>  12
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Tyr Cys Ile Leu Gly Arg Ile Gly Glu Gly Ala His Gly Ile Val 
1               5                   10                  15      


Phe Lys Ala Lys His Val Glu Thr Gly Glu Ile Val Ala Leu Lys Lys 
            20                  25                  30          


Val Ala Leu Arg Arg Leu Glu Asp Gly Phe Pro Asn Gln Ala Leu Arg 
        35                  40                  45              


Glu Ile Lys Ala Leu Gln Glu Met Glu Asp Asn Gln Tyr Val Val Gln 
    50                  55                  60                  


Leu Lys Ala Val Phe Pro His Gly Gly Gly Phe Val Leu Ala Phe Glu 
65                  70                  75                  80  


Phe Met Leu Ser Asp Leu Ala Glu Val Val Arg His Ala Gln Arg Pro 
                85                  90                  95      


Leu Ala Gln Ala Gln Val Lys Ser Tyr Leu Gln Met Leu Leu Lys Gly 
            100                 105                 110         


Val Ala Phe Cys His Ala Asn Asn Ile Val His Arg Asp Leu Lys Pro 
        115                 120                 125             


Ala Asn Leu Leu Ile Ser Ala Ser Gly Gln Leu Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Val Phe Ser Pro Asp Gly Ser Arg Leu Tyr Thr His 
145                 150                 155                 160 


Gln Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Tyr Gly Ala 
                165                 170                 175     


Arg Gln Tyr Asp Gln Gly Val Asp Leu Trp Ser Val Gly Cys Ile Met 
            180                 185                 190         


Gly Glu Leu Leu Asn Gly 
        195             


<210>  13
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly Thr Val 
1               5                   10                  15      


Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu Lys Arg 
            20                  25                  30          


Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala Leu Arg 
        35                  40                  45              


Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val Arg Leu 
    50                  55                  60                  


His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe Glu Phe 
65                  70                  75                  80  


Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly Asp Leu 
                85                  90                  95      


Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys Gly Leu 
            100                 105                 110         


Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys Pro Gln 
        115                 120                 125             


Asn Leu Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp Phe Gly 
    130                 135                 140                 


Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala Glu Val 
145                 150                 155                 160 


Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala Lys Leu 
                165                 170                 175     


Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe Ala Glu 
            180                 185                 190         


Leu Ala Asn Ala 
        195     


<210>  14
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Phe Gln Cys Leu Asn Arg Ile Glu Glu Gly Thr Tyr Gly Val Val 
1               5                   10                  15      


Tyr Arg Ala Lys Asp Lys Lys Thr Asp Glu Ile Val Ala Leu Lys Arg 
            20                  25                  30          


Leu Lys Met Glu Lys Glu Lys Glu Gly Phe Pro Ile Thr Ser Leu Arg 
        35                  40                  45              


Glu Ile Asn Thr Ile Leu Lys Ala Gln His Pro Asn Ile Val Thr Val 
    50                  55                  60                  


Arg Glu Ile Val Val Ser Asn Met Asp Lys Ile Tyr Ile Val Met Asn 
65                  70                  75                  80  


Tyr Val Glu His Asp Leu Lys Ser Leu Met Glu Thr Met Lys Gln Pro 
                85                  90                  95      


Phe Leu Pro Gly Glu Val Lys Thr Leu Met Ile Gln Leu Leu Arg Gly 
            100                 105                 110         


Val Lys His Leu His Asp Asn Trp Ile Leu His Arg Asp Leu Lys Thr 
        115                 120                 125             


Ser Asn Leu Leu Leu Ser His Ala Gly Ile Leu Lys Val Gly Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Tyr Gly Ser Pro Leu Lys Ala Tyr Thr Pro Val 
145                 150                 155                 160 


Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala Lys 
                165                 170                 175     


Glu Tyr Ser Thr Ala Val Asp Met Trp Ser Val Gly Cys Ile Phe Gly 
            180                 185                 190         


Glu Leu Leu Thr Gln 
        195         


<210>  15
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Phe Glu Lys Leu Asn Arg Ile Gly Glu Gly Thr Tyr Gly Ile Val 
1               5                   10                  15      


Tyr Arg Ala Arg Asp Thr Gln Thr Asp Glu Ile Val Ala Leu Lys Lys 
            20                  25                  30          


Val Arg Met Asp Lys Glu Lys Asp Gly Ile Pro Ile Ser Ser Leu Arg 
        35                  40                  45              


Glu Ile Thr Leu Leu Leu Arg Leu Arg His Pro Asn Ile Val Glu Leu 
    50                  55                  60                  


Lys Glu Val Val Val Gly Asn His Leu Glu Ser Ile Phe Leu Val Met 
65                  70                  75                  80  


Gly Tyr Cys Glu Gln Asp Leu Ala Ser Leu Leu Glu Asn Met Pro Thr 
                85                  90                  95      


Pro Phe Ser Glu Ala Gln Val Lys Cys Ile Val Leu Gln Val Leu Arg 
            100                 105                 110         


Gly Leu Gln Tyr Leu His Arg Asn Phe Ile Ile His Arg Asp Leu Lys 
        115                 120                 125             


Val Ser Asn Leu Leu Met Thr Asp Lys Gly Cys Val Lys Thr Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Tyr Gly Val Pro Val Lys Pro Met Thr Pro 
145                 150                 155                 160 


Lys Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Thr 
                165                 170                 175     


Thr Thr Gln Thr Thr Ser Ile Asp Met Trp Ala Val Gly Cys Ile Leu 
            180                 185                 190         


Ala Glu Leu Leu Ala His 
        195             


<210>  16
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Tyr Val Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
1               5                   10                  15      


Phe Lys Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu 
            20                  25                  30          


Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
        35                  40                  45              


Val Ser Leu Leu Lys Asn Leu Lys His Ala Asn Ile Val Thr Leu His 
    50                  55                  60                  


Asp Leu Ile His Thr Asp Arg Ser Leu Thr Leu Val Phe Glu Tyr Leu 
65                  70                  75                  80  


Asp Ser Asp Leu Lys Gln Tyr Leu Asp His Cys Gly Asn Leu Met Ser 
                85                  90                  95      


Met His Asn Val Lys Ile Phe Met Phe Gln Leu Leu Arg Gly Leu Ala 
            100                 105                 110         


Tyr Cys His His Arg Lys Ile Leu His Arg Asp Leu Lys Pro Gln Asn 
        115                 120                 125             


Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
145                 150                 155                 160 


Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Thr Glu Tyr 
                165                 170                 175     


Ser Thr Pro Ile Asp Met Trp Gly Val Gly Cys Ile His Tyr Glu Met 
            180                 185                 190         


Ala Thr Gly 
        195 


<210>  17
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
1               5                   10                  15      


Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala Leu Lys Glu 
            20                  25                  30          


Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
        35                  40                  45              


Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His 
    50                  55                  60                  


Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu 
65                  70                  75                  80  


Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn Ile Ile Asn 
                85                  90                  95      


Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ala 
            100                 105                 110         


Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn 
        115                 120                 125             


Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
145                 150                 155                 160 


Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser Thr Asp Tyr 
                165                 170                 175     


Ser Thr Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Tyr Glu Met 
            180                 185                 190         


Ala Thr Gly 
        195 


<210>  18
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr Tyr Ile Lys Leu Glu Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
1               5                   10                  15      


Tyr Lys Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu 
            20                  25                  30          


Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
        35                  40                  45              


Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His 
    50                  55                  60                  


Asp Ile Val His Thr Asp Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu 
65                  70                  75                  80  


Asp Lys Asp Leu Lys Gln Tyr Met Asp Asp Cys Gly Asn Ile Met Ser 
                85                  90                  95      


Met His Asn Val Lys Leu Phe Leu Tyr Gln Ile Leu Arg Gly Leu Ala 
            100                 105                 110         


Tyr Cys His Arg Arg Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn 
        115                 120                 125             


Leu Leu Ile Asn Glu Lys Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
145                 150                 155                 160 


Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Ser Glu Tyr 
                165                 170                 175     


Ser Thr Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Phe Glu Met 
            180                 185                 190         


Ala Ser Gly 
        195 


<210>  19
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Tyr Glu Lys Leu Asp Phe Leu Gly Glu Gly Gln Phe Ala Thr Val 
1               5                   10                  15      


Tyr Lys Ala Arg Asp Lys Asn Thr Asn Gln Ile Val Ala Ile Lys Lys 
            20                  25                  30          


Ile Lys Leu Gly His Arg Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr 
        35                  40                  45              


Ala Leu Arg Glu Ile Lys Leu Leu Gln Glu Leu Ser His Pro Asn Ile 
    50                  55                  60                  


Ile Gly Leu Leu Asp Ala Phe Gly His Lys Ser Asn Ile Ser Leu Val 
65                  70                  75                  80  


Phe Asp Phe Met Glu Thr Asp Leu Glu Val Ile Ile Lys Asp Asn Ser 
                85                  90                  95      


Leu Val Leu Thr Pro Ser His Ile Lys Ala Tyr Met Leu Met Thr Leu 
            100                 105                 110         


Gln Gly Leu Glu Tyr Leu His Gln His Trp Ile Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Asn Asn Leu Leu Leu Asp Glu Asn Gly Val Leu Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Lys Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr 
145                 150                 155                 160 


His Gln Val Val Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly 
                165                 170                 175     


Ala Arg Met Tyr Gly Val Gly Val Asp Met Trp Ala Val Gly Cys Ile 
            180                 185                 190         


Leu Ala Glu Leu Leu Leu Arg 
        195                 


<210>  20
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Tyr Glu Cys Val Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val 
1               5                   10                  15      


Phe Lys Ala Arg Asp Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys 
            20                  25                  30          


Arg Val Arg Val Gln Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile 
        35                  40                  45              


Arg Glu Val Ala Val Leu Arg His Leu Glu Thr Phe Glu His Pro Asn 
    50                  55                  60                  


Val Val Arg Leu Phe Asp Val Cys Thr Asp Arg Glu Thr Lys Leu Thr 
65                  70                  75                  80  


Leu Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys 
                85                  90                  95      


Val Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe 
            100                 105                 110         


Gln Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His 
        115                 120                 125             


Arg Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile 
    130                 135                 140                 


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala 
145                 150                 155                 160 


Leu Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu 
                165                 170                 175     


Leu Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys 
            180                 185                 190         


Ile Phe Ala Glu Met Phe Arg Arg 
        195                 200 


<210>  21
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly Ser Tyr Ala Thr Val 
1               5                   10                  15      


Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu Val Ala Leu Lys Val 
            20                  25                  30          


Ile Arg Leu Gln Glu Glu Glu Gly Thr Pro Phe Thr Ala Ile Arg Glu 
        35                  40                  45              


Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val Leu Leu His 
    50                  55                  60                  


Asp Ile Ile His Thr Lys Glu Thr Leu Thr Leu Val Phe Glu Tyr Val 
65                  70                  75                  80  


His Thr Asp Leu Cys Gln Tyr Met Asp Lys His Pro Gly Gly Leu His 
                85                  90                  95      


Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ser 
            100                 105                 110         


Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp Leu Lys Pro Gln Asn 
        115                 120                 125             


Leu Leu Ile Ser Asp Thr Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Ala Lys Ser Val Pro Ser His Thr Tyr Ser Asn Glu Val Val 
145                 150                 155                 160 


Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Thr Glu Tyr 
                165                 170                 175     


Ser Thr Cys Leu Asp Met Trp Gly Val Gly Cys Ile Phe Val Glu Met 
            180                 185                 190         


Ile Gln Gly 
        195 


<210>  22
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly Ser Tyr Ala Thr Val 
1               5                   10                  15      


Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu Val Ala Leu Lys Val 
            20                  25                  30          


Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe Thr Ala Ile Arg Glu 
        35                  40                  45              


Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val Leu Leu His 
    50                  55                  60                  


Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe Val Phe Glu Tyr Met 
65                  70                  75                  80  


His Thr Asp Leu Ala Gln Tyr Met Ser Gln His Pro Gly Gly Leu His 
                85                  90                  95      


Pro His Asn Val Arg Leu Phe Met Phe Gln Leu Leu Arg Gly Leu Ala 
            100                 105                 110         


Tyr Ile His His Gln His Val Leu His Arg Asp Leu Lys Pro Gln Asn 
        115                 120                 125             


Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr Ser Ser Glu Val Val 
145                 150                 155                 160 


Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu Gly Ala Thr Glu Tyr 
                165                 170                 175     


Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys Ile Phe Ile Glu Met 
            180                 185                 190         


Phe Gln Gly 
        195 


<210>  23
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala Tyr Gly Thr Val 
1               5                   10                  15      


Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val Ala Leu Lys Ser 
            20                  25                  30          


Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly Leu Pro Ile Ser 
        35                  40                  45              


Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu Ala Phe Glu His 
    50                  55                  60                  


Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Asp Arg Glu Ile Lys 
65                  70                  75                  80  


Val Thr Leu Val Phe Glu His Val Asp Gln Asp Leu Arg Thr Tyr Leu 
                85                  90                  95      


Asp Lys Ala Pro Pro Pro Gly Leu Pro Ala Glu Thr Ile Lys Asp Leu 
            100                 105                 110         


Met Arg Gln Phe Leu Arg Gly Leu Asp Phe Leu His Ala Asn Cys Ile 
        115                 120                 125             


Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu Val Thr Ser Gly Gly 
    130                 135                 140                 


Thr Val Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Tyr Gln 
145                 150                 155                 160 


Met Ala Leu Thr Pro Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu 
                165                 170                 175     


Val Leu Leu Gln Ser Thr Tyr Ala Thr Pro Val Asp Met Trp Ser Val 
            180                 185                 190         


Gly Cys Ile Phe Ala Glu Met Phe Arg Arg 
        195                 200         


<210>  24
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Tyr Glu Lys Ile Gly Lys Ile Gly Glu Gly Ser Tyr Gly Val Val 
1               5                   10                  15      


Phe Lys Cys Arg Asn Arg Asp Thr Gly Gln Ile Val Ala Ile Lys Lys 
            20                  25                  30          


Phe Leu Glu Ser Glu Asp Asp Pro Val Ile Lys Lys Ile Ala Leu Arg 
        35                  40                  45              


Glu Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu Val Asn Leu 
    50                  55                  60                  


Leu Glu Val Phe Arg Arg Lys Arg Arg Leu His Leu Val Phe Glu Tyr 
65                  70                  75                  80  


Cys Asp His Thr Val Leu His Glu Leu Asp Arg Tyr Gln Arg Gly Val 
                85                  90                  95      


Pro Glu His Leu Val Lys Ser Ile Thr Trp Gln Thr Leu Gln Ala Val 
            100                 105                 110         


Asn Phe Cys His Lys His Asn Cys Ile His Arg Asp Val Lys Pro Glu 
        115                 120                 125             


Asn Ile Leu Ile Thr Lys His Ser Val Ile Lys Leu Cys Asp Phe Gly 
    130                 135                 140                 


Phe Ala Arg Leu Leu Thr Gly Pro Ser Asp Tyr Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Val Gly Asp Thr Gln 
                165                 170                 175     


Tyr Gly Pro Pro Val Asp Val Trp Ala Ile Gly Cys Val Phe Ala Glu 
            180                 185                 190         


Leu Leu Ser Gly 
        195     


<210>  25
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly Met Val 
1               5                   10                  15      


Met Lys Cys Arg Asn Lys Asp Thr Gly Arg Ile Val Ala Ile Lys Lys 
            20                  25                  30          


Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala Met Arg 
        35                  40                  45              


Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val Asn Leu 
    50                  55                  60                  


Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe Glu Phe 
65                  70                  75                  80  


Val Asp His Thr Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn Gly Leu 
                85                  90                  95      


Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn Gly Ile 
            100                 105                 110         


Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys Pro Glu 
        115                 120                 125             


Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp Phe Gly 
    130                 135                 140                 


Phe Ala Arg Thr Leu Ala Ala Pro Gly Glu Val Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp Val Lys 
                165                 170                 175     


Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val Thr Glu 
            180                 185                 190         


Met Phe Met Gly 
        195     


<210>  26
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Tyr Thr Asn Leu Ser Tyr Ile Gly Glu Gly Ala Tyr Gly Met Val 
1               5                   10                  15      


Cys Ser Ala Tyr Asp Asn Val Asn Lys Val Arg Val Ala Ile Lys Lys 
            20                  25                  30          


Ile Ser Pro Phe Glu His Gln Thr Tyr Cys Gln Arg Thr Leu Arg Glu 
        35                  40                  45              


Ile Lys Ile Leu Leu Arg Phe Arg His Glu Asn Ile Ile Gly Ile Asn 
    50                  55                  60                  


Asp Ile Ile Arg Glu Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu 
65                  70                  75                  80  


Met Glu Thr Asp Leu Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn 
                85                  90                  95      


Asp His Ile Cys Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr 
            100                 105                 110         


Ile His Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu 
        115                 120                 125             


Leu Leu Asn Thr Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala 
    130                 135                 140                 


Arg Val Ala Asp Pro Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr 
145                 150                 155                 160 


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys 
                165                 170                 175     


Gly Tyr Thr Lys Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala 
            180                 185                 190         


Glu Met Leu Ser Asn 
        195         


<210>  27
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Tyr Thr Gln Leu Gln Tyr Ile Gly Glu Gly Ala Tyr Gly Met Val 
1               5                   10                  15      


Ser Ser Ala Tyr Asp His Val Arg Lys Thr Arg Val Ala Ile Lys Lys 
            20                  25                  30          


Ile Ser Pro Phe Glu His Gln Thr Tyr Cys Gln Arg Thr Leu Arg Glu 
        35                  40                  45              


Ile Gln Ile Leu Leu Arg Phe Arg His Glu Asn Val Ile Gly Ile Arg 
    50                  55                  60                  


Asp Ile Leu Arg Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu 
65                  70                  75                  80  


Met Glu Thr Asp Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn 
                85                  90                  95      


Asp His Ile Cys Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr 
            100                 105                 110         


Ile His Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu 
        115                 120                 125             


Leu Ile Asn Thr Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala 
    130                 135                 140                 


Arg Ile Ala Asp Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr 
145                 150                 155                 160 


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys 
                165                 170                 175     


Gly Tyr Thr Lys Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala 
            180                 185                 190         


Glu Met Leu Ser Asn 
        195         


<210>  28
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Tyr Glu Ile Ile Glu Thr Ile Gly Asn Gly Ala Tyr Gly Val Val 
1               5                   10                  15      


Ser Ser Ala Arg Arg Arg Leu Thr Gly Gln Gln Val Ala Ile Lys Lys 
            20                  25                  30          


Ile Pro Asn Ala Phe Asp Val Val Thr Asn Ala Lys Arg Thr Leu Arg 
        35                  40                  45              


Glu Leu Lys Ile Leu Lys His Phe Lys His Asp Asn Ile Ile Ala Ile 
    50                  55                  60                  


Lys Asp Ile Leu Arg Gly Glu Phe Lys Ser Val Tyr Val Val Leu Asp 
65                  70                  75                  80  


Leu Met Glu Ser Asp Leu His Gln Ile Ile Ser Ser Gln Pro Leu Thr 
                85                  90                  95      


Leu Glu His Val Arg Tyr Phe Leu Tyr Gln Leu Leu Arg Gly Leu Lys 
            100                 105                 110         


Tyr Met His Ser Ala Gln Val Ile His Arg Asp Leu Lys Pro Ser Asn 
        115                 120                 125             


Leu Leu Val Asn Glu Asn Cys Glu Leu Lys Ile Gly Asp Phe Gly Met 
    130                 135                 140                 


Ala Arg Gly Leu Cys Ser Pro Ala Glu His Gln Tyr Phe Met Thr Glu 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Met Leu Ser Leu 
                165                 170                 175     


His Glu Tyr Thr Gln Ala Ile Asp Leu Trp Ser Val Gly Cys Ile Phe 
            180                 185                 190         


Gly Glu Met Leu Ala Arg 
        195             


<210>  29
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Tyr Arg Asp Leu Gln Pro Val Gly Ser Gly Ala Tyr Gly Ala Val 
1               5                   10                  15      


Cys Ser Ala Val Asp Gly Arg Thr Gly Ala Lys Val Ala Ile Lys Lys 
            20                  25                  30          


Leu Tyr Arg Pro Phe Gln Ser Glu Leu Phe Ala Lys Arg Ala Tyr Arg 
        35                  40                  45              


Glu Leu Arg Leu Leu Lys His Met Arg His Glu Asn Val Ile Gly Leu 
    50                  55                  60                  


Leu Asp Val Phe Thr Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro 
65                  70                  75                  80  


Phe Met Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly 
                85                  90                  95      


Glu Asp Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg 
            100                 105                 110         


Tyr Ile His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn 
        115                 120                 125             


Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr 
                165                 170                 175     


Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly 
            180                 185                 190         


<210>  30
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly Ser Val 
1               5                   10                  15      


Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile Lys Arg 
            20                  25                  30          


Met Lys Arg Lys Phe Tyr Ser Trp Asp Glu Cys Met Asn Leu Arg Glu 
        35                  40                  45              


Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Ile Lys Leu Lys 
    50                  55                  60                  


Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu Tyr Met 
65                  70                  75                  80  


Lys Glu Asn Leu Tyr Gln Leu Met Asp Arg Asn Lys Leu Phe Pro Glu 
                85                  90                  95      


Ser Val Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly Leu Ala Phe 
            100                 105                 110         


Ile His Lys His Gly Phe Phe His Arg Asp Met Lys Pro Glu Asn Leu 
        115                 120                 125             


Leu Cys Met Glu Leu Val Lys Ile Ala Asp Phe Gly Leu Ala Arg Glu 
    130                 135                 140                 


Leu Arg Pro Pro Tyr Thr Asp Tyr Val Ser Thr Arg Trp Tyr Arg Ala 
145                 150                 155                 160 


Pro Glu Val Leu Leu Arg Ser Ser Val Tyr Ser Ser Pro Ile Asp Val 
                165                 170                 175     


Trp Ala Val Gly Ser Ile Met Ala Glu Leu Tyr Met Leu 
            180                 185                 


<210>  31
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Tyr Glu Gly Cys Lys Val Gly Arg Gly Thr Tyr Gly His Val Tyr 
1               5                   10                  15      


Lys Ala Arg Arg Lys Asp Gly Lys Asp Glu Lys Glu Tyr Ala Leu Lys 
            20                  25                  30          


Gln Ile Glu Gly Thr Gly Ile Ser Met Ser Ala Cys Arg Glu Ile Ala 
        35                  40                  45              


Leu Leu Arg Glu Leu Lys His Pro Asn Val Ile Ala Leu Gln Lys Val 
    50                  55                  60                  


Phe Leu His Ser Asp Arg Lys Val Trp Leu Leu Phe Asp Tyr Ala Glu 
65                  70                  75                  80  


His Asp Leu Trp His Ile Ile Lys Ala Asn Lys Lys Pro Met Gln Leu 
                85                  90                  95      


Pro Arg Ser Met Val Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile 
            100                 105                 110         


His Tyr Leu His Ala Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala 
        115                 120                 125             


Asn Ile Leu Val Met Glu Arg Gly Arg Val Lys Ile Ala Asp Met Gly 
    130                 135                 140                 


Phe Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala Asp Leu Asp 
145                 150                 155                 160 


Pro Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly 
                165                 170                 175     


Ala Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Leu Leu Thr Ser 
        195                 


<210>  32
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Ile Glu Pro Asp Arg Pro Ile Gly Tyr Gly Ala Phe Gly Val Val 
1               5                   10                  15      


Trp Ser Val Thr Asp Pro Arg Asp Gly Lys Arg Val Ala Leu Lys Lys 
            20                  25                  30          


Met Pro Asn Val Phe Gln Asn Leu Val Ser Cys Lys Arg Val Phe Arg 
        35                  40                  45              


Glu Leu Lys Met Leu Cys Phe Phe Lys His Asp Asn Val Leu Ser Ala 
    50                  55                  60                  


Leu Asp Ile Leu Gln Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu 
65                  70                  75                  80  


Leu Met Gln Ser Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu 
                85                  90                  95      


Ser Ser Asp His Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu 
            100                 105                 110         


Lys Tyr Leu His Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly 
        115                 120                 125             


Asn Leu Leu Val Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly 
    130                 135                 140                 


Leu Ala Arg Val Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu 
145                 150                 155                 160 


Val Val Thr Gln Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg 
                165                 170                 175     


His Tyr Ser Asn Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala 
            180                 185                 190         


Glu Leu Leu Gly Arg 
        195         


<210>  33
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Tyr Val Ser Pro Thr His Val Gly Ser Gly Ala Tyr Gly Ser Val 
1               5                   10                  15      


Cys Ser Ala Ile Asp Lys Arg Ser Gly Glu Lys Val Ala Ile Lys Lys 
            20                  25                  30          


Leu Ser Arg Pro Phe Gln Ser Glu Ile Phe Ala Lys Arg Ala Tyr Arg 
        35                  40                  45              


Glu Leu Leu Leu Leu Lys His Met Gln His Glu Asn Val Ile Gly Leu 
    50                  55                  60                  


Leu Asp Val Phe Thr Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro 
65                  70                  75                  80  


Phe Met Gln Thr Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu 
                85                  90                  95      


Glu Lys Ile Gln Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr 
            100                 105                 110         


Ile His Ser Ala Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu 
        115                 120                 125             


Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala 
    130                 135                 140                 


Arg His Ala Asp Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr 
145                 150                 155                 160 


Arg Ala Pro Glu Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val 
                165                 170                 175     


Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly 
            180                 185                 190     


<210>  34
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Tyr Leu Leu Arg Arg Gln Leu Gly Gln Gly Ala Tyr Gly Ile Val 
1               5                   10                  15      


Trp Lys Ala Val Asp Arg Arg Thr Gly Glu Val Val Ala Ile Lys Lys 
            20                  25                  30          


Ile Phe Asp Ala Phe Arg Asp Lys Thr Asp Ala Gln Arg Thr Phe Arg 
        35                  40                  45              


Glu Ile Thr Leu Leu Gln Glu Phe Gly Asp His Pro Asn Ile Ile Ser 
    50                  55                  60                  


Leu Leu Asp Val Ile Arg Glu Asn Asp Arg Asp Ile Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Met Asp Thr Asp Leu Asn Ala Val Ile Arg Lys Gly Gly Leu 
                85                  90                  95      


Leu Gln Asp Val His Val Arg Ser Ile Phe Tyr Gln Leu Leu Arg Ala 
            100                 105                 110         


Thr Arg Phe Leu His Ser Gly His Val Val His Arg Asp Gln Lys Pro 
        115                 120                 125             


Ser Asn Val Leu Leu Asp Ala Asn Cys Thr Val Lys Leu Cys Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Ser Leu Gly Gly Pro Glu Asp Gln Ala Val Thr Glu 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Ser Ser 
                165                 170                 175     


His Arg Tyr Thr Leu Gly Val Asp Met Trp Ser Leu Gly Cys Ile Leu 
            180                 185                 190         


Gly Glu Met Leu Arg Gly 
        195             


