
				SEQUENCE LISTING

<110> Krystal Biotech, Inc.
      KRISHNAN, Suma
      AGARWAL, Pooja
      FREEDMAN, John C.
      O'MALLEY, Mark E.
      REGULA, Lauren K.

<120> COMPOSITIONS AND METHODS FOR THE
  TREATMENT OF AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS
  

<130> 761342000540

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> US 62/656,768       
<151> 2018-04-12

<160> 10

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2454
<212> DNA
<213> Homo sapiens

<400> 1
atgatggatg ggccacgttc cgatgtgggc cgttggggtg gcaacccctt gcagccccct 60
accacgccat ctccagagcc agagccagag ccagacggac gctctcgcag aggaggaggc 120
cgttccttct gggctcgctg ctgtggctgc tgttcatgcc gaaatgcggc agatgacgac 180
tggggacctg aaccctctga ctccaggggt cgagggtcca gctctggcac tcgaagacct 240
ggctcccggg gctcagactc ccgccggcct gtatcccggg gcagcggtgt caatgcagct 300
ggagatggca ccatccgaga gggcatgcta gtagtgaacg gtgtggactt gctgagctcg 360
cgctcggacc agaaccgccg agagcaccac acagacgagt atgagtacga cgagctgata 420
gtgcgccgcg ggcagccttt ccatatgctc ctcctcctgt cccggaccta tgaatcctct 480
gatcgcatca cccttgagtt actcatcgga aacaaccccg aggtgggcaa gggcacgcac 540
gtgatcatcc cagtgggcaa ggggggcagt ggaggctgga aagcccaggt ggtcaaggcc 600
agtgggcaga atctgaacct gcgggtccac acttccccca acgccatcat cggcaagttt 660
cagttcacag tccgcacaca atcagacgct ggggagttcc agttgccctt tgacccccgc 720
aatgagatct acatcctctt caacccctgg tgcccagagg acattgtgta cgtggaccat 780
gaggattggc ggcaggagta tgttcttaat gagtctggga gaatttacta cgggaccgaa 840
gcacagattg gtgagcggac ctggaactac ggccagtttg accacggggt gctggatgcc 900
tgcttataca tcctggaccg gcgggggatg ccatatggag gccgtggaga cccagtcaat 960
gtctcccggg tcatctctgc catggtgaac tccctggatg acaatggagt cctgattggg 1020
aactggtctg gtgattactc ccgaggcacc aacccatcag cgtgggtggg cagcgtggag 1080
atcctgctta gctacctacg cacgggatat tccgtcccct atggccagtg ctgggtcttt 1140
gctggcgtga ccaccacagt gctgcgctgc ctgggtctgg ccacccgtac tgtcaccaac 1200
ttcaactccg cccacgacac agacacatcc cttaccatgg acatctactt cgacgagaac 1260
atgaagcccc tggagcacct gaaccatgat tctgtctgga acttccatgt gtggaacgac 1320
tgctggatga agaggccgga tctgccctcg ggctttgatg ggtggcaggt ggtggatgcc 1380
acaccccaag agactagcag tggcatcttc tgctgcggcc cctgctctgt ggagtccatc 1440
aagaatggcc tggtctacat gaagtacgac acgcctttca tttttgctga ggtgaatagt 1500
gacaaggtgt actggcagcg gcaggatgat ggcagcttca agattgttta tgtggaggag 1560
aaggccatcg gcacactcat tgtcacaaag gccatcagct ccaacatgcg ggaggacatc 1620
acctacctct ataagcaccc agaaggctca gacgcagagc ggaaggcagt agagacagca 1680
gcagcccacg gcagcaaacc caatgtgtat gccaaccggg gctcagcgga ggatgtggcc 1740
atgcaggtgg aggcacagga cgcggtgatg gggcaggatc tgatggtctc tgtgatgctg 1800
atcaatcaca gcagcagccg ccgcacagtg aaactgcacc tctacctctc agtcactttc 1860
tatactggtg tcagtggtac catcttcaag gagaccaaga aggaagtgga gctggcacca 1920
ggggcctcgg accgtgtgac catgccagtg gcctacaagg aataccggcc ccatcttgtg 1980
gaccaggggg ccatgctgct caatgtctca ggccacgtca aggagagcgg gcaggtgctg 2040
gccaagcagc acaccttccg tctgcgcacc ccagacctct ccctcacgtt actgggagca 2100
gcagtggttg gccaggagtg tgaagtacag attgtcttca agaaccccct tcccgtcacc 2160
ctcaccaatg tcgtcttccg gctcgaaggc tctgggttac agaggcccaa gatcctcaac 2220
gttggggaca ttggaggcaa tgaaacagtg acactgcgcc agtcgtttgt gcctgtgcga 2280
ccaggccccc gccagctcat tgccagcttg gacagcccac agctctccca ggtgcacggt 2340
gtcatccagg tggatgtggc cccagcccct ggggatgggg gcttcttctc agacgctgga 2400
ggtgacagtc acttaggaga gaccatccct atggcatctc gaggtggagc ttag       2454

<210> 2
<211> 2454
<212> DNA
<213> Artifical Sequence

<220>
<223> Synthetic Construct

<400> 2
atgatggacg gccctagatc cgatgttggc agatggggcg gaaaccctct gcagcctcct 60
accacacctt ctccagagcc tgaacctgag cctgacggca gatctagaag aggcggcgga 120
agatccttct gggccagatg ctgtggctgc tgcagctgta gaaacgccgc cgacgatgat 180
tggggccctg agccttctga tagcagaggc agaggctcta gcagcggcac aagaaggcct 240
ggctctagag gcagcgatag cagacggcct gtgtccagag gttctggcgt gaacgctgct 300
ggcgacggca caatcagaga aggcatgctg gtggtcaacg gcgtggacct gctgagcagc 360
agaagcgacc agaacagaag agagcaccac accgacgagt acgagtatga cgagctgatc 420
gtgcggagag gccagccttt tcacatgttg ctgctgctga gccggaccta cgagagcagc 480
gacagaatca ccctggaact gctgatcggc aacaaccccg aagtcggcaa gggcacccac 540
gtgatcatcc ctgttggcaa aggtggcagc ggaggatgga aagcccaggt ggtcaaagcc 600
agcggccaga atctgaatct gcgggtgcac acaagcccca acgccatcat cggcaagttc 660
cagtttaccg tgcggaccca gtctgacgcc ggcgaatttc agctgccctt cgatccccgg 720
aacgagatct acatcctgtt caacccttgg tgccccgagg acatcgtgta cgtggaccac 780
gaggattggc ggcaagagta cgtgctgaac gagagcggca ggatctacta cggaacagag 840
gcccagatcg gcgagcggac atggaattac ggccagttcg atcacggcgt gctggacgcc 900
tgtctgtaca tcctggatag acgcggcatg ccctatggcg gaagaggcga tcctgtgaat 960
gtgtctagag tgatcagcgc catggtcaac agcctggacg acaatggcgt gctgattggc 1020
aattggagcg gcgactacag caggggcaca aatccatctg cctgggtcgg aagcgtggaa 1080
atcctgctgt cctacctgag aaccggctac agcgtgccct acggacagtg ttgggttttc 1140
gctggcgtga ccaccaccgt gctgagatgt ctgggactcg ccaccagaac cgtgaccaac 1200
ttcaacagcg cccacgacac cgataccagc ctgaccatgg acatctactt cgacgagaac 1260
atgaagcccc tggaacacct gaaccacgac agcgtgtgga acttccacgt gtggaatgac 1320
tgctggatga agcggcccga tctgccctct ggattcgatg gatggcaggt cgtggacgcc 1380
acacctcaag agacaagctc cggcatcttc tgctgtggcc cttgcagcgt ggaatccatc 1440
aagaacggac tggtgtacat gaagtacgac acgcccttca tcttcgccga agtgaacagc 1500
gacaaggtgt actggcagag acaggacgac ggcagcttca agattgtgta tgtggaagag 1560
aaggccatcg gcaccctgat cgtgaccaag gccatcagct ccaacatgag agaggacatc 1620
acctacctgt acaagcaccc cgagggctcc gatgccgaga gaaaagctgt ggaaacagct 1680
gccgctcacg gcagcaagcc taacgtgtac gccaatagag gctccgccga ggacgtggcc 1740
atgcaggttg aagctcagga tgccgtgatg ggccaagacc tgatggtgtc cgtgatgctg 1800
atcaaccaca gcagctccag acggaccgtg aagctgcacc tgtacctgtc cgtgaccttc 1860
tacacaggcg tgtccggcac catcttcaaa gaaacaaaga aagaggtcga gctggcccca 1920
ggcgccagcg atagagttac aatgcccgtg gcctacaaag agtacagacc ccacctggtg 1980
gatcagggcg ctatgctgct gaatgtctcc ggccacgtga aagaaagcgg acaggtgctg 2040
gccaagcagc acaccttcag actgagaacc cctgatctgt ctctgaccct gctgggagcc 2100
gctgttgtgg gacaagagtg cgaggtgcag atcgtgttca agaatcccct gcctgtgaca 2160
ctgaccaacg tggtgttcag actggaaggc tctggcctgc agcggcctaa gatcctgaat 2220
gtgggagaca tcggcggcaa cgagacagtg accctgagac agagctttgt gcctgtgcgg 2280
cctggaccta gacagctgat tgccagcctg gatagcccac agctgtctca agtgcacggc 2340
gtgatccagg tggacgttgc accagctcca ggcgacggcg gctttttttc tgatgccggc 2400
ggagattctc acctgggcga gacaattccc atggccagta gaggcggagc ttga       2454

<210> 3
<211> 2448
<212> DNA
<213> Mus musculus

<400> 3
atggaaggtc ctcgctcaga cgtgggccgc tggggcagga gcccctggca gccccctaca 60
acaccgtcac cggagccaga gccggtgccg gagccagaca gacgctcgcg ctcccgccga 120
ggaggaggcc gctccttctg ggctcgttgt tgtggctgct gctcatgtgg gaacagaggg 180
gacgatgact ggggacctga accttctggc tccagaagca gagggaccag ctcccggggt 240
agggactctc ggggtggccg aagacccgag tctcggggca gtggtgtaaa tgcagctgga 300
gatggcacca tccgagaggg aatgctggtt gtgactggtg tggatctgct gtgctcacga 360
tcagaccaga accgccgaga gcaccacacg gatgagtttg aatatgatga gctgattgtg 420
cgccgtgggc agcccttcca catgatcctt ttcttgaacc gggaatatga gtcctctgat 480
cgcattgccc ttgagctcct cattggaagc aatccggagg tgggcaaggg cacccacgtg 540
atcatcccag tgggtaaggg aggcagtggt ggctggaagg cccaagtgac taagaacaac 600
ggacacaacc taaacctacg cgtccacacc tcccccaatg ccatcattgg caagtttcag 660
ttcactgtcc gcacccgctc tgaagctgga gagttccagt tgccctttga cccccgcaat 720
gagatctaca tcctcttcaa tccctggtgc ccagaggaca tagtgtatgt ggaccatgag 780
gactggcggc aagaatatgt gcttaatgag tctggaagaa tctactatgg aacagaagca 840
cagattggcg aacgaacctg gaactatggt cagtttgacc atggggtgct ggatgcctgc 900
ctgtacatcc tggatcggag ggggatgcca tatggaggtc gtggggaccc agtcagtgtc 960
tctcgggttg tctctgccat ggtgaactcc ctggatgaca atggagttct gattgggaac 1020
tggaccggtg actactctcg aggcaccaac ccctcagcgt gggtgggcag tgtggagatc 1080
ctgctcagct acctacgcac cggctattcc gtcccctacg gccaatgctg ggtctttgcc 1140
ggtgtgacca ccacagtgct ccgatgtctg ggcttcgcta cccgtaccgt caccaacttc 1200
aactctgcac acgacacaga cacctccctc actatggaca tctactttga tgagaacatg 1260
aagccacttg aacatctgaa ccatgattct gtttggaact tccacgtgtg gaacgactgc 1320
tggatgaaga ggccagatct gccctcaggc tttgatgggt ggcaggttgt ggatgccaca 1380
ccccaggaga ccagcagtgg catcttctgc tgtggcccct gttctgtgga gtccgtcaag 1440
aatggcttag tctacatgaa gtatgacaca cctttcattt ttgctgaggt aaatagcgat 1500
aaggtatact ggcagcggca ggatgatggc agctttaaga tagtgtacgt ggaagagaaa 1560
gccattggca cactcattgt cacaaaggcg atccactcca acaatcgaga ggacatcacc 1620
cacatctata agcacccaga aggctcagaa gcagagcgga gggctgtgga gaaggcggca 1680
gcccatggca gcaaacctaa tgtgtatgcc acccgggact ccgctgagga tgtggcaatg 1740
caggtggagg cgcaggacgc tgtgatgggg caggatctgg ctgtctctgt ggtgctgacc 1800
aatcgtggta gtagccgacg cactgtgaag ttgcacctct acctttgtgt cacctactac 1860
actggtgtct ctgggcctac cttcaaggag gccaaaaagg aagtgacatt agccccagga 1920
gcctcggact ctgtgaccat gcctgtggcc tacaaggaat acaagcccca ccttgtggac 1980
cagggggcaa tgttgctcaa tgtctcaggc catgtcaagg agagtgggca ggtactagcc 2040
aagcaacaca ccttccgttt gcgcacccca gacctttctc ttacgttact gggagcagca 2100
gttgttggtc aggaatgtgg agtacagatc gtgttcaaga accccctgcc tgtcaccctc 2160
accaacgtcg tcttccggct cgaaggttct ggattacaga gacccaaggt cctcaatgtc 2220
ggggacatcg ggggtaatga gacagtcaca ctgcgccaga cgtttgttcc cgtgcgacca 2280
ggcccccgcc agctcattgc cagcctggac agtccacagc tttcccaagt gcacggtgtt 2340
attcaagtgg atgtggcccc agcctctgga ggcagcggtt tctcagatgc tggaggtgac 2400
agtcgctctg gggagaacat acctatggca tatcgaggtg gagcttaa              2448

<210> 4
<211> 2475
<212> DNA
<213> Rattus norvegicus

<400> 4
atggaaggtc ctcgctcaga cgtgggccgc tggggtagga gcccctggca gcccacgaca 60
ccgtcgccag agccagagcc agagccagag ccagacagaa gctcgcgctc ccgccgagga 120
ggaggccgct ccttctgggc tcgctgttgt ggctgctgct cctgcgggaa cagagctgat 180
gatgactggg gacccgaacc ttctggctcc agaagccgag ggaccagctc ccggggtgga 240
ggctcccggg gtggggactc tcggggtagg gactctcgag gtggccgaag acctgagtct 300
cggggcagtg gtgtgaatgc agctggagat ggcaccatcc gagagggaat gctggttgtg 360
aatggtgtag atctgctgtg ctcgcgatca gaccagaacc gccgagagca ccacaccgat 420
gagtttgaat atgacgagct aattttgcgc cgtgggcagc ccttccacat aatcctcttc 480
ctgaaccggg agtatgagtc ctctgatcgc attgcccttg agcttctcat cggaaacaat 540
cctgaggtgg gcaagggcac ccacgtgatc atcccagtgg gtaagggagg cagcggtggc 600
tggaaggccc aagtgactaa gaccaatgga cacaacctaa ccctgcgcgt ccacacctcc 660
cctaatgcca tcattggcaa gtttcaattc actgtccgta cacgctcaga ggctggcgag 720
ttccagctgc cctttgaccc ccgcaatgag atctacatcc tcttcaatcc ctggtgtcca 780
gaggacatag tgtatgtgga ccacgaagac tggcgacaag aatatgtgct taatgagtct 840
ggaagaatct actatgggac agaagcacag attggcgaac ggacctggaa ttatggccag 900
tttgaccatg gggtgctgga tgcctgcctg tacattctgg atcggagggg gatgccatat 960
ggaggtcgcg gggacccagt cagtgtctct cgggtcgtct ctgccatggt gaactccctg 1020
gatgacaatg gagttctgat tgggaactgg actggcgact actctcgagg caccaatccc 1080
tcagcgtggg tgggcagtgt ggagatcctg cttagctacc tacgcaccgg ctattccgtc 1140
ccctatggcc aatgctgggt ctttgccggt gtgaccacca cagtgctccg atgtctgggc 1200
cttgctaccc gtactgtcac caacttcaac tctgcacacg acacggacac gtccctcact 1260
atggacattt attttgatga gaacatgaag ccactggagc acctgaacca cgattctgtt 1320
tggaacttcc acgtgtggaa cgactgctgg atgaagaggc cagatctgcc ctcaggcttt 1380
gatgggtggc aggttgtgga tgccacaccc caggagacca gcagtggcat cttctgctgt 1440
ggcccctgtt cagtggagtc catcaagaat ggcttagtct acatgaagta tgacacacct 1500
ttcatttttg ccgaggtaaa cagtgataag gtatactggc agcggcagga tgacggcagc 1560
ttcaagatcg tgtatgtgga agagaaagcc attggcacac tgattgtcac aaaggcgatc 1620
aactccaaca tgcgagagga catcacccac atctataagc acccagaagg ctcagaagca 1680
gagaggaagg ctgtggaaaa ggctgcggcc catggcagca aacctaatgt gtatgccacc 1740
cgggactctg ctgaggatgt ggcaatgcag gtggaggcac aggatgctgt gatggggcag 1800
gatctgactg tctctgtggt gttgaccaat cgtggcagta gccgacgcac tgtgaagttg 1860
cacctctacc tttgtgtcac ctactacact ggtgtctctg ggcctacctt caaggagacc 1920
aagaaagaag tggtattagc cccaggagcc tcggacactg tggccatgcc tgtggcctac 1980
aaggaataca agccccacct tgtggaccag ggggcaatgt tgctcaatgt ctcaggccat 2040
gtcaaggaga gtgggcaggt actagccaag caacacacct tccgtttgcg caccccagac 2100
ctctctctga cattactggg agctgcagta gttggccagg aatgtgaagt ccagatcgtg 2160
ttcaagaacc ccctgcctat caccctcacc aacgttgtct tccggctcga aggttctggg 2220
ttacagagac ccaaggtcct caatgttggg gacatcgggg gtaacgagac ggttacactg 2280
cgccagacat ttgttcctgt gcgaccaggc ccccgccagc tcattgccag tctggacagt 2340
ccacagcttt cccaagtaca cggtgtcatt caagtggatg tggccccatc ctctggaggc 2400
agaggtttct cagaggctgt aggtgacagt cgctccgggg agaacatacc tatggcattt 2460
cgaggtggag cttag                                                  2475

<210> 5
<211> 817
<212> PRT
<213> Homo sapiens

<400> 5
Met Met Asp Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Gly Asn Pro
 1               5                  10                  15    
Leu Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Asp
            20                  25                  30 
Gly Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala Arg Cys Cys
        35                  40                  45    
Gly Cys Cys Ser Cys Arg Asn Ala Ala Asp Asp Asp Trp Gly Pro Glu
    50                  55                  60      
Pro Ser Asp Ser Arg Gly Arg Gly Ser Ser Ser Gly Thr Arg Arg Pro
65                  70                  75                  80 
Gly Ser Arg Gly Ser Asp Ser Arg Arg Pro Val Ser Arg Gly Ser Gly
                85                  90                  95 
Val Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val Val 
            100                 105                 110    
Asn Gly Val Asp Leu Leu Ser Ser Arg Ser Asp Gln Asn Arg Arg Glu
        115                 120                 125    
His His Thr Asp Glu Tyr Glu Tyr Asp Glu Leu Ile Val Arg Arg Gly
    130                 135                 140      
Gln Pro Phe His Met Leu Leu Leu Leu Ser Arg Thr Tyr Glu Ser Ser
145                 150                 155                 160
Asp Arg Ile Thr Leu Glu Leu Leu Ile Gly Asn Asn Pro Glu Val Gly
                165                 170                 175
Lys Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly
            180                 185                 190   
Trp Lys Ala Gln Val Val Lys Ala Ser Gly Gln Asn Leu Asn Leu Arg
        195                 200                 205 
Val His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val
    210                 215                 220    
Arg Thr Gln Ser Asp Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro Arg
225                 230                 235                 240
Asn Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile Val
                245                 250                 255 
Tyr Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser
            260                 265                 270
Gly Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp
        275                 280                 285    
Asn Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile
    290                 295                 300   
Leu Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Asn
305                 310                 315                 320
Val Ser Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly
                325                 330                 335 
Val Leu Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly Thr Asn Pro
            340                 345                 350     
Ser Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr
        355                 360                 365      
Gly Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr
    370                 375                 380    
Thr Thr Val Leu Arg Cys Leu Gly Leu Ala Thr Arg Thr Val Thr Asn
385                 390                 395                 400 
Phe Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr
                405                 410                 415 
Phe Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val
            420                 425                 430  
Trp Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu
        435                 440                 445   
Pro Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu
    450                 455                 460      
Thr Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Ile
465                 470                 475                 480
Lys Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala
                485                 490                 495  
Glu Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser
            500                 505                 510 
Phe Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val
        515                 520                 525 
Thr Lys Ala Ile Ser Ser Asn Met Arg Glu Asp Ile Thr Tyr Leu Tyr
    530                 535                 540     
Lys His Pro Glu Gly Ser Asp Ala Glu Arg Lys Ala Val Glu Thr Ala
545                 550                 555                 560 
Ala Ala His Gly Ser Lys Pro Asn Val Tyr Ala Asn Arg Gly Ser Ala
                565                 570                 575 
Glu Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln
            580                 585                 590 
Asp Leu Met Val Ser Val Met Leu Ile Asn His Ser Ser Ser Arg Arg
        595                 600                 605  
Thr Val Lys Leu His Leu Tyr Leu Ser Val Thr Phe Tyr Thr Gly Val
    610                 615                 620  
Ser Gly Thr Ile Phe Lys Glu Thr Lys Lys Glu Val Glu Leu Ala Pro
625                 630                 635                 640
Gly Ala Ser Asp Arg Val Thr Met Pro Val Ala Tyr Lys Glu Tyr Arg
                645                 650                 655   
Pro His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly His
            660                 665                 670     
Val Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu
        675                 680                 685     
Arg Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val Gly
    690                 695                 700      
Gln Glu Cys Glu Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr
705                 710                 715                 720
Leu Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro
                725                 730                 735 
Lys Ile Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu
            740                 745                 750
Arg Gln Ser Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala
        755                 760                 765  
Ser Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val
    770                 775                 780    
Asp Val Ala Pro Ala Pro Gly Asp Gly Gly Phe Phe Ser Asp Ala Gly
785                 790                 795                 800
Gly Asp Ser His Leu Gly Glu Thr Ile Pro Met Ala Ser Arg Gly Gly 
                805                 810                 815
Ala

<210> 6
<211> 815
<212> PRT
<213> Mus musculus

<400> 6
Met Glu Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Arg Ser Pro Trp
 1               5                  10                  15 
Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Glu Pro
            20                  25                  30 
Asp Arg Arg Ser Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala
        35                  40                  45  
Arg Cys Cys Gly Cys Cys Ser Cys Gly Asn Arg Gly Asp Asp Asp Trp
    50                  55                  60      
Gly Pro Glu Pro Ser Gly Ser Arg Ser Arg Gly Thr Ser Ser Arg Gly
65                  70                  75                  80
Arg Asp Ser Arg Gly Gly Arg Arg Pro Glu Ser Arg Gly Ser Gly Val
                85                  90                  95 
Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val Val Thr
            100                 105                 110  
Gly Val Asp Leu Leu Cys Ser Arg Ser Asp Gln Asn Arg Arg Glu His
        115                 120                 125    
His Thr Asp Glu Phe Glu Tyr Asp Glu Leu Ile Val Arg Arg Gly Gln
    130                 135                 140     
Pro Phe His Met Ile Leu Phe Leu Asn Arg Glu Tyr Glu Ser Ser Asp
145                 150                 155                 160
Arg Ile Ala Leu Glu Leu Leu Ile Gly Ser Asn Pro Glu Val Gly Lys
                165                 170                 175
Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly Trp
            180                 185                 190   
Lys Ala Gln Val Thr Lys Asn Asn Gly His Asn Leu Asn Leu Arg Val
        195                 200                 205 
His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val Arg
    210                 215                 220    
Thr Arg Ser Glu Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro Arg Asn
225                 230                 235                 240
Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile Val Tyr
                245                 250                 255 
Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser Gly
            260                 265                 270
Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp Asn
        275                 280                 285   
Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile Leu
    290                 295                 300   
Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Ser Val
305                 310                 315                 320
Ser Arg Val Val Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly Val
                325                 330                 335 
Leu Ile Gly Asn Trp Thr Gly Asp Tyr Ser Arg Gly Thr Asn Pro Ser
            340                 345                 350  
Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr Gly
        355                 360                 365      
Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr Thr
    370                 375                 380    
Thr Val Leu Arg Cys Leu Gly Phe Ala Thr Arg Thr Val Thr Asn Phe
385                 390                 395                 400
Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr Phe
                405                 410                 415 
Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val Trp
            420                 425                 430  
Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu Pro
        435                 440                 445   
Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu Thr
    450                 455                 460     
Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Val Lys
465                 470                 475                 480
Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala Glu
                485                 490                 495  
Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser Phe
            500                 505                 510 
Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val Thr
        515                 520                 525 
Lys Ala Ile His Ser Asn Asn Arg Glu Asp Ile Thr His Ile Tyr Lys
    530                 535                 540     
His Pro Glu Gly Ser Glu Ala Glu Arg Arg Ala Val Glu Lys Ala Ala
545                 550                 555                 560
Ala His Gly Ser Lys Pro Asn Val Tyr Ala Thr Arg Asp Ser Ala Glu
                565                 570                 575 
Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln Asp
            580                 585                 590 
Leu Ala Val Ser Val Val Leu Thr Asn Arg Gly Ser Ser Arg Arg Thr
        595                 600                 605  
Val Lys Leu His Leu Tyr Leu Cys Val Thr Tyr Tyr Thr Gly Val Ser
    610                 615                 620  
Gly Pro Thr Phe Lys Glu Ala Lys Lys Glu Val Thr Leu Ala Pro Gly
625                 630                 635                 640
Ala Ser Asp Ser Val Thr Met Pro Val Ala Tyr Lys Glu Tyr Lys Pro
                645                 650                 655   
His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly His Val
            660                 665                 670     
Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu Arg
        675                 680                 685  
Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val Gly Gln
    690                 695                 700    
Glu Cys Gly Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr Leu
705                 710                 715                 720
Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro Lys
                725                 730                 735 
Val Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu Arg
            740                 745                 750
Gln Thr Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala Ser
        755                 760                 765  
Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val Asp
    770                 775                 780    
Val Ala Pro Ala Ser Gly Gly Ser Gly Phe Ser Asp Ala Gly Gly Asp
785                 790                 795                 800
Ser Arg Ser Gly Glu Asn Ile Pro Met Ala Tyr Arg Gly Gly Ala
                805                 810                 815

<210> 7
<211> 824
<212> PRT
<213> Rattus norvegicus

<400> 7
Met Glu Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Arg Ser Pro Trp
 1               5                  10                  15 
Gln Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Glu Pro Asp
            20                  25                  30 
Arg Ser Ser Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala Arg
        35                  40                  45 
Cys Cys Gly Cys Cys Ser Cys Gly Asn Arg Ala Asp Asp Asp Trp Gly
    50                  55                  60 
Pro Glu Pro Ser Gly Ser Arg Ser Arg Gly Thr Ser Ser Arg Gly Gly
65                  70                  75                  80
Gly Ser Arg Gly Gly Asp Ser Arg Gly Arg Asp Ser Arg Gly Gly Arg
                85                  90                  95 
Arg Pro Glu Ser Arg Gly Ser Gly Val Asn Ala Ala Gly Asp Gly Thr
            100                 105                 110  
Ile Arg Glu Gly Met Leu Val Val Asn Gly Val Asp Leu Leu Cys Ser
        115                 120                 125    
Arg Ser Asp Gln Asn Arg Arg Glu His His Thr Asp Glu Phe Glu Tyr
    130                 135                 140 
Asp Glu Leu Ile Leu Arg Arg Gly Gln Pro Phe His Ile Ile Leu Phe
145                 150                 155                 160
Leu Asn Arg Glu Tyr Glu Ser Ser Asp Arg Ile Ala Leu Glu Leu Leu
                165                 170                 175
Ile Gly Asn Asn Pro Glu Val Gly Lys Gly Thr His Val Ile Ile Pro
            180                 185                 190   
Val Gly Lys Gly Gly Ser Gly Gly Trp Lys Ala Gln Val Thr Lys Thr
        195                 200                 205 
Asn Gly His Asn Leu Thr Leu Arg Val His Thr Ser Pro Asn Ala Ile
    210                 215                 220   
Ile Gly Lys Phe Gln Phe Thr Val Arg Thr Arg Ser Glu Ala Gly Glu
225                 230                 235                 240
Phe Gln Leu Pro Phe Asp Pro Arg Asn Glu Ile Tyr Ile Leu Phe Asn
                245                 250                 255
Pro Trp Cys Pro Glu Asp Ile Val Tyr Val Asp His Glu Asp Trp Arg
            260                 265                 270
Gln Glu Tyr Val Leu Asn Glu Ser Gly Arg Ile Tyr Tyr Gly Thr Glu
        275                 280                 285   
Ala Gln Ile Gly Glu Arg Thr Trp Asn Tyr Gly Gln Phe Asp His Gly
    290                 295                 300   
Val Leu Asp Ala Cys Leu Tyr Ile Leu Asp Arg Arg Gly Met Pro Tyr
305                 310                 315                 320
Gly Gly Arg Gly Asp Pro Val Ser Val Ser Arg Val Val Ser Ala Met
                325                 330                 335
Val Asn Ser Leu Asp Asp Asn Gly Val Leu Ile Gly Asn Trp Thr Gly
            340                 345                 350 
Asp Tyr Ser Arg Gly Thr Asn Pro Ser Ala Trp Val Gly Ser Val Glu
        355                 360                 365     
Ile Leu Leu Ser Tyr Leu Arg Thr Gly Tyr Ser Val Pro Tyr Gly Gln
    370                 375                 380    
Cys Trp Val Phe Ala Gly Val Thr Thr Thr Val Leu Arg Cys Leu Gly
385                 390                 395                 400
Leu Ala Thr Arg Thr Val Thr Asn Phe Asn Ser Ala His Asp Thr Asp
                405                 410                 415 
Thr Ser Leu Thr Met Asp Ile Tyr Phe Asp Glu Asn Met Lys Pro Leu
            420                 425                 430 
Glu His Leu Asn His Asp Ser Val Trp Asn Phe His Val Trp Asn Asp
        435                 440                 445   
Cys Trp Met Lys Arg Pro Asp Leu Pro Ser Gly Phe Asp Gly Trp Gln
    450                 455                 460  
Val Val Asp Ala Thr Pro Gln Glu Thr Ser Ser Gly Ile Phe Cys Cys
465                 470                 475                 480
Gly Pro Cys Ser Val Glu Ser Ile Lys Asn Gly Leu Val Tyr Met Lys
                485                 490                 495
Tyr Asp Thr Pro Phe Ile Phe Ala Glu Val Asn Ser Asp Lys Val Tyr
            500                 505                 510 
Trp Gln Arg Gln Asp Asp Gly Ser Phe Lys Ile Val Tyr Val Glu Glu
        515                 520                 525 
Lys Ala Ile Gly Thr Leu Ile Val Thr Lys Ala Ile Asn Ser Asn Met
    530                 535                 540 
Arg Glu Asp Ile Thr His Ile Tyr Lys His Pro Glu Gly Ser Glu Ala
545                 550                 555                 560
Glu Arg Lys Ala Val Glu Lys Ala Ala Ala His Gly Ser Lys Pro Asn
                565                 570                 575
Val Tyr Ala Thr Arg Asp Ser Ala Glu Asp Val Ala Met Gln Val Glu
            580                 585                 590 
Ala Gln Asp Ala Val Met Gly Gln Asp Leu Thr Val Ser Val Val Leu
        595                 600                 605  
Thr Asn Arg Gly Ser Ser Arg Arg Thr Val Lys Leu His Leu Tyr Leu
    610                 615                 620  
Cys Val Thr Tyr Tyr Thr Gly Val Ser Gly Pro Thr Phe Lys Glu Thr
625                 630                 635                 640
Lys Lys Glu Val Val Leu Ala Pro Gly Ala Ser Asp Thr Val Ala Met
                645                 650                 655 
Pro Val Ala Tyr Lys Glu Tyr Lys Pro His Leu Val Asp Gln Gly Ala
            660                 665                 670  
Met Leu Leu Asn Val Ser Gly His Val Lys Glu Ser Gly Gln Val Leu
        675                 680                 685  
Ala Lys Gln His Thr Phe Arg Leu Arg Thr Pro Asp Leu Ser Leu Thr
    690                 695                 700    
Leu Leu Gly Ala Ala Val Val Gly Gln Glu Cys Glu Val Gln Ile Val
705                 710                 715                 720
Phe Lys Asn Pro Leu Pro Ile Thr Leu Thr Asn Val Val Phe Arg Leu
                725                 730                 735 
Glu Gly Ser Gly Leu Gln Arg Pro Lys Val Leu Asn Val Gly Asp Ile
            740                 745                 750
Gly Gly Asn Glu Thr Val Thr Leu Arg Gln Thr Phe Val Pro Val Arg
        755                 760                 765  
Pro Gly Pro Arg Gln Leu Ile Ala Ser Leu Asp Ser Pro Gln Leu Ser
    770                 775                 780    
Gln Val His Gly Val Ile Gln Val Asp Val Ala Pro Ser Ser Gly Gly
785                 790                 795                 800
Arg Gly Phe Ser Glu Ala Val Gly Asp Ser Arg Ser Gly Glu Asn Ile
                805                 810                 815
Pro Met Ala Phe Arg Gly Gly Ala
            820

<210> 8
<211> 818
<212> PRT
<213> Pan troglodytes

<400> 8
Met Met Asp Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Gly Asn Pro
 1               5                  10                  15 
Leu Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Asp
            20                  25                  30 
Gly Arg Ser Arg Arg Gly Gly Gly Gly Arg Ser Phe Trp Ala Arg Cys
        35                  40                  45 
Cys Gly Cys Cys Ser Cys Arg Asn Ala Ala Asp Asp Asp Trp Gly Pro
    50                  55                  60 
Glu Pro Ser Asp Ser Arg Gly Arg Gly Ser Ser Ser Gly Thr Arg Arg
65                  70                  75                  80
Pro Gly Ser Arg Gly Ser Asp Ser Arg Arg Pro Val Ser Arg Gly Ser
                85                  90                  95 
Gly Val Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val
            100                 105                 110 
Val Asn Gly Val Asp Leu Leu Ser Ser Arg Ser Asp Gln Asn Arg Arg
        115                 120                 125  
Glu His His Thr Asp Glu Tyr Glu Tyr Asp Glu Leu Ile Val Arg Arg
    130                 135                 140 
Gly Gln Pro Phe His Met Leu Leu Leu Leu Ser Arg Thr Tyr Glu Ser
145                 150                 155                 160
Ser Asp Arg Ile Thr Leu Glu Leu Leu Ile Gly Asn Asn Pro Glu Val
                165                 170                 175
Gly Lys Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly
            180                 185                 190  
Gly Trp Lys Ala Gln Val Val Lys Ala Ser Gly Gln Asn Leu Asn Leu
        195                 200                 205 
Arg Val His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr
    210                 215                 220   
Val Arg Thr Gln Ser Asp Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro
225                 230                 235                 240
Arg Asn Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile
                245                 250                 255
Val Tyr Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu
            260                 265                 270
Ser Gly Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr
        275                 280                 285   
Trp Asn Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr
    290                 295                 300   
Ile Leu Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val
305                 310                 315                 320
Ser Val Ser Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn
                325                 330                 335
Gly Val Leu Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly Thr Asn
            340                 345                 350 
Pro Ser Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg
        355                 360                 365  
Thr Gly Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val
    370                 375                 380    
Thr Thr Thr Val Leu Arg Cys Leu Gly Leu Ala Thr Arg Thr Val Thr
385                 390                 395                 400
Asn Phe Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile
                405                 410                 415 
Tyr Phe Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser
            420                 425                 430 
Val Trp Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp
        435                 440                 445  
Leu Pro Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln
    450                 455                 460  
Glu Thr Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser
465                 470                 475                 480
Ile Lys Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe
                485                 490                 495
Ala Glu Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly
            500                 505                 510 
Ser Phe Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile
        515                 520                 525 
Val Thr Lys Ala Ile Ser Ser Asn Met Arg Glu Asp Ile Thr Tyr Leu
    530                 535                 540 
Tyr Lys His Pro Glu Gly Ser Asp Ala Glu Arg Lys Ala Val Glu Thr
545                 550                 555                 560
Ala Ala Ala His Gly Ser Lys Pro Asn Val Tyr Ala Asn Arg Gly Ser
                565                 570                 575
Ala Glu Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly
            580                 585                 590 
Gln Asp Leu Met Val Ser Val Met Leu Thr Asn His Ser Ser Ser Arg
        595                 600                 605  
Arg Thr Val Lys Leu His Leu Tyr Leu Ser Val Thr Phe Tyr Thr Gly
    610                 615                 620  
Val Ser Gly Thr Ile Phe Lys Glu Thr Lys Lys Glu Val Glu Leu Ala
625                 630                 635                 640
Pro Gly Ala Ser Asp Arg Val Thr Met Pro Val Ala Tyr Lys Glu Tyr
                645                 650                 655 
Arg Pro His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly
            660                 665                 670  
His Val Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg
        675                 680                 685  
Leu Arg Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val
    690                 695                 700    
Gly Gln Glu Cys Glu Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val
705                 710                 715                 720
Thr Leu Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg
                725                 730                 735 
Pro Lys Ile Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr
            740                 745                 750
Leu Arg Gln Ser Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile
        755                 760                 765 
Ala Ser Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln
    770                 775                 780    
Val Asp Val Ala Pro Ala Pro Gly Asp Gly Gly Phe Phe Ser Asp Ala
785                 790                 795                 800
Gly Gly Asp Ser His Leu Gly Glu Thr Ile Pro Met Ala Ser Arg Gly
                805                 810                 815
Gly Ala

<210> 9
<211> 836
<212> PRT
<213> Oryctolagus cuniculus

<400> 9
Met Asp Gly Pro Arg Ser Asp Met Gly Arg Ser Asp Val Ser Arg Ser
 1               5                  10                  15 
Asp Met Ser Arg Ser Asp Met Gly Arg Ser Asp Met Gly Arg Ser Asp
            20                  25                  30 
Val Gly Arg Cys Gly Gly Gly Pro Leu Gln Pro Ser Ala Thr Pro Ser
        35                  40                  45 
Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Asp Arg Gly Ser Arg
    50                  55                  60 
Ser Arg Gly Gly Arg Gly Arg Ser Phe Trp Ala Arg Cys Cys Gly Cys
65                  70                  75                  80
Cys Ser Cys Arg Asn Ala Ala Asp Asp Asp Trp Gly Arg Glu Pro Ser
                85                  90                  95 
Asp Ser Arg Asp Arg Gly Ser Ser Ser Arg Gly Gly Arg Pro Asp Ser
            100                 105                 110 
Arg Gly Gly Gly Val Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly
        115                 120                 125 
Met Leu Val Val Thr Gly Val Asp Leu Leu Ser Ser Arg Ser Asp Gln
    130                 135                 140 
Asn Arg Arg Glu His His Thr Asp Glu Phe Glu Tyr Glu Glu Leu Ile
145                 150                 155                 160
Val Arg Arg Gly Gln Pro Phe His Leu Val Leu Phe Leu Ser Arg Pro
                165                 170                 175
Tyr Glu Ser Ser Asp Arg Ile Ala Leu Glu Leu Gln Ile Gly Asn Asn
            180                 185                 190 
Pro Glu Val Gly Lys Gly Thr His Val Ile Ile Pro Val Gly Lys Gly
        195                 200                 205 
Asn Ser Gly Gly Trp Lys Ala Gln Val Thr Lys Ala Ser Gly Gln Thr
    210                 215                 220   
Leu Asn Leu Arg Val His Ser Pro Ala Ser Ala Ile Ile Gly Lys Phe
225                 230                 235                 240
Gln Phe Thr Val Arg Thr Arg Thr Glu Ala Gly Glu Phe Gln Leu Pro
                245                 250                 255
Phe Asp Pro Arg Asn Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro
            260                 265                 270
Glu Asp Ile Val Tyr Val Asp His Glu Asp Trp Arg Gln Asp Tyr Val
        275                 280                 285  
Leu Asn Glu Ser Gly Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly
    290                 295                 300   
Glu Arg Thr Trp Asn Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala
305                 310                 315                 320
Cys Leu Tyr Ile Leu Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly
                325                 330                 335
Asp Pro Val Ser Val Ser Arg Val Ile Ser Ala Met Val Asn Ser Leu
            340                 345                 350 
Asp Asp Asn Gly Val Leu Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg
        355                 360                 365  
Gly Thr Asn Pro Ser Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser
    370                 375                 380  
Tyr Leu Arg Thr Gly Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe
385                 390                 395                 400
Ala Gly Val Thr Thr Thr Val Leu Arg Cys Leu Gly Leu Ala Thr Arg
                405                 410                 415
Thr Val Thr Asn Phe Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr
            420                 425                 430 
Met Asp Ile Tyr Phe Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn
        435                 440                 445  
Arg Asp Ser Val Trp Asn Phe His Val Trp Asn Asp Cys Trp Met Lys
    450                 455                 460  
Arg Pro Asp Leu Pro Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala
465                 470                 475                 480
Thr Pro Gln Glu Thr Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser
                485                 490                 495
Val Glu Ser Val Lys Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro
            500                 505                 510 
Phe Ile Phe Ala Glu Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln
        515                 520                 525 
Asp Asp Gly Ser Phe Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly
    530                 535                 540 
Thr Leu Ile Val Thr Lys Ala Val Arg Ser His Met Arg Glu Asp Ile
545                 550                 555                 560
Thr His Ile Tyr Lys His Pro Glu Gly Ser Asp Ala Glu Arg Lys Ala
                565                 570                 575
Val Glu Thr Ala Ala Ala His Gly Ser Lys Pro Asn Val Tyr Asp Ser
            580                 585                 590 
Arg Asp Ser Ala Glu Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala
        595                 600                 605  
Val Met Gly Gln Asp Leu Thr Val Ser Val Val Leu Thr Asn Arg Ser
    610                 615                 620  
Ser Ser Arg Arg Thr Val Lys Leu His Leu Tyr Leu Ser Val Thr Phe
625                 630                 635                 640
Tyr Thr Gly Val Thr Gly Ser Ile Phe Lys Glu Ser Lys Lys Glu Val
                645                 650                 655 
Val Leu Ala Ala Gly Ser Ser Asp Ser Val Val Met Pro Val Ala Tyr
            660                 665                 670
Lys Glu Tyr Arg Pro His Leu Val Asp Gln Gly Ala Met Leu Leu Asn
        675                 680                 685  
Val Ser Gly His Val Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His
    690                 695                 700    
Thr Phe Arg Val Arg Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala
705                 710                 715                 720
Ala Val Val Gly Gln Glu Cys Glu Val Gln Ile Val Phe Arg Asn Pro
                725                 730                 735 
Leu Pro Ile Thr Leu Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly
            740                 745                 750
Leu Gln Arg Pro Lys Ile Leu Asn Val Gly Asp Ile Gly Gly Asn Glu
        755                 760                 765 
Thr Val Thr Leu Arg Gln Thr Phe Val Pro Val Arg Pro Gly Pro Arg
    770                 775                 780    
Gln Leu Ile Ala Ser Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly
785                 790                 795                 800
Val Ile Gln Val Asp Val Ala Pro Ala Ser Gly Gly Arg Gly Phe Leu
                805                 810                 815
His Ala Gly Gly Asp Ser Tyr Ser Gly Glu Thr Ile Pro Met Thr Ser
            820                 825                 830       
Arg Gly Glu Ala
        835

<210> 10
<211> 815
<212> PRT
<213> Canis lupus familiaris

<400> 10
Met Asp Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Gly Asn Pro Trp
 1               5                  10                  15 
Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Glu Pro
            20                  25                  30 
Glu Arg Arg Ser Arg Arg Gly Gly Arg Ser Phe Trp Ala Arg Cys Cys
        35                  40                  45 
Gly Cys Cys Ser Cys Arg Asn Arg Ala Asp Asp Asp Trp Gly Pro Glu
    50                  55                  60 
Pro His Arg Asp Arg Gly Ser Gly Ser Gly Arg Arg Arg Pro Asp Ser
65                  70                  75                  80
Arg Gly Ser Asp Ser Arg Arg Pro Gly Ser Arg Ala Ser Gly Val Asn
                85                  90                  95 
Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val Val Thr Gly
            100                 105                 110 
Val Asp Leu Leu Ser Ser Arg Ser Asp Gln Asn Arg Arg Glu His His
        115                 120                 125 
Thr Asp Glu Phe Glu Tyr Asp Glu Leu Ile Ile Arg Arg Gly Gln Pro
    130                 135                 140 
Phe His Met Val Leu His Phe Ser Arg Pro Tyr Glu Ser Ser Asp Arg
145                 150                 155                 160
Val Ala Leu Glu Leu Leu Ile Gly Asn Asn Pro Glu Val Gly Lys Gly
                165                 170                 175
Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly Trp Lys
            180                 185                 190 
Ala Gln Val Thr Lys Ala Ser Gly Gln Asn Leu Asn Leu Arg Val His
        195                 200                 205 
Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val Arg Thr
    210                 215                 220   
His Ser Glu Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro His Asn Glu
225                 230                 235                 240
Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile Val Tyr Val
                245                 250                 255
Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser Gly Arg
            260                 265                 270
Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp Asn Tyr
        275                 280                 285  
Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile Leu Asp
    290                 295                 300   
Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Ser Val Ser
305                 310                 315                 320
Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly Val Leu
                325                 330                 335
Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly Thr Asn Pro Ser Ala
            340                 345                 350 
Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr Gly Tyr
        355                 360                 365  
Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr Thr Thr
    370                 375                 380  
Val Leu Arg Cys Leu Gly Leu Ala Thr Arg Thr Val Thr Asn Phe Asn
385                 390                 395                 400
Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr Phe Asp
                405                 410                 415
Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val Trp Asn
            420                 425                 430 
Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu Pro Ser
        435                 440                 445  
Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu Thr Ser
    450                 455                 460  
Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Ile Lys Asn
465                 470                 475                 480
Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala Glu Val
                485                 490                 495
Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser Phe Lys
            500                 505                 510 
Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val Thr Lys
        515                 520                 525 
Ala Val Gly Ser Asn Met Gln Asp Asp Val Thr His Ile Tyr Lys His
    530                 535                 540 
Pro Glu Gly Ser Glu Ala Glu Arg Lys Ala Val Glu Thr Ala Ala Ala
545                 550                 555                 560
His Gly Ser Lys Pro Asn Val Tyr Thr Asn Arg Asp Ser Ala Glu Asp
                565                 570                 575
Val Ala Leu Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln Asp Leu
            580                 585                 590 
Thr Val Ser Val Val Leu Thr Asn Arg Gly Ser Ser Thr Arg Thr Val
        595                 600                 605  
Lys Leu His Leu Tyr Leu Ser Val Thr Phe Tyr Thr Gly Val Thr Gly
    610                 615                 620  
Pro Val Phe Lys Glu Ser Lys Lys Glu Val Val Leu Ala Pro Gly Ala
625                 630                 635                 640
Thr Glu Arg Val Ser Met Pro Val Ala Tyr Lys Glu Tyr Arg Pro Gln
                645                 650                 655 
Ile Val Asp Gln Gly Ser Met Leu Leu Asn Val Ser Gly His Val Lys
            660                 665                 670
Glu Asn Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu Arg Thr
        675                 680                 685  
Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val Gly Gln Glu
    690                 695                 700    
Cys Glu Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr Leu Thr
705                 710                 715                 720
Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro Lys Ile
                725                 730                 735 
Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu His Gln
            740                 745                 750
Lys Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala Ser Leu
        755                 760                 765 
Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val Asp Val
    770                 775                 780    
Ala Pro Ala Pro Gly Gly Gly Gly Phe Phe Ser Asn Ala Gly Gly Asn
785                 790                 795                 800
Ser Pro Leu Gly Glu Thr Ile Pro Met Ala Ser Arg Gly Gly Ala
                805                 810                 815