                         SEQUENCE LISTING

<110>  Y-BIOLOGICS, INC.
 
<120>  CELL ENGAGING BINDING MOLECULES

<130>  14489-004-228

<140>
<141>

<150>  US 16/372,196
<151>  2019-04-01

<150>  US 16/372,190
<151>  2019-04-01

<150>  US 16/372,172
<151>  2019-04-01

<150>  US 62/719,484
<151>  2018-08-17

<150>  US 62/655,762
<151>  2018-04-10

<160>  129   

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-05-VH amino acid sequence

<400>  1

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
                245                 250                 255     


Glu Leu Val Lys Pro Gly Pro Ser Met Lys Ile Ser Cys Lys Ala Ser 
            260                 265                 270         


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His 
        275                 280                 285             


Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val 
    290                 295                 300                 


Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu 
                325                 330                 335     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser 
            340                 345                 350         


Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe 
        355                 360                 365             


Ser 
    


<210>  2
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-05-VL amino acid sequence

<400>  2

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
                245                 250                 255     


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
            260                 265                 270         


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
        275                 280                 285             


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
    290                 295                 300                 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
305                 310                 315                 320 


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
                325                 330                 335     


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
            340                 345                 350         


Ile Lys Arg 
        355 


<210>  3
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-05-LC amino acid sequence

<400>  3

Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ile Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in VH of ACE-04, ACE-05, ACE-09, and ACE-12

<400>  4

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in CDR H1 of ACE-04, ACE-05, ACE-09, and 
       ACE-12

<400>  5

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in CDR H2 of ACE-04, ACE-05, ACE-09, and 
       ACE-12

<400>  6

Ile Ile Pro Ile Leu Gly Ile Ala 
1               5               


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) CDR H3 of ACE-04, ACE-05, ACE-09, and ACE-12

<400>  7

Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile 
1               5                   10                  


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in VL of ACE-04, ACE-05, ACE-09, and ACE-12

<400>  8

Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ile Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg 
            100                 105                 110         


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in CDR L1 of ACE-04, ACE-05, ACE-09, and 
       ACE-12

<400>  9

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  10
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in CDR L2 of ACE-04, ACE-05, ACE-09, and 
       ACE-12

<400>  10

Gly Asp Ile 
1           


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (PD-L1) in CDR L3 of ACE-04, ACE-05, ACE-09, and 
       ACE-12

<400>  11

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Gly Val 
1               5                   10      


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VH of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Pro 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
        115                 120         


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H1 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  13

Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H2 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  14

Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
1               5                   10  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H3 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  15

Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VL of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  16

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L1 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  17

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L2 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  18

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L3 of ACE-05, ACE-09, ACE-10, ACE-11, and 
       ACE-12

<400>  19

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  20
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-05-VH nucleotide sequence

<400>  20
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tgaggtgcag ctccagcagt ctggacctga gctggtgaag      780

cctggacctt caatgaagat atcctgcaag gcttctggtt actcattcac tggctacacc      840

atgaactggg tgaagcagag tcatggaaag aaccttgagt ggatgggact tattaatcct      900

tacaaaggtg ttagtaccta caaccagaag ttcaaggaca aggccacact gactgtagac      960

aagtcatcca gcacagccta catggaactc ctcagtctga catctgagga ctctgcagtc     1020

tattactgtg caagatcggg gtactacggt gatagtgact ggtacttcga tgtctggggc     1080

caggggacca cgctgaccgt cttctcataa                                      1110


<210>  21
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-05-VL nucleotide sequence

<400>  21
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tgacatccag atgacccaga ccacctcctc cctgtctgcc      780

tccctgggcg acagagtcac catcagttgc agggcaagtc aggacattag aaattattta      840

aactggtatc aacagaaacc agatggaact gttaaactcc tgatctacta cacatcaaga      900

ttacactcag gagtcccatc aaagttcagt ggcagtgggt ctggaacaga ttattctctc      960

accattagca acctggagca agaggatatt gccacttact tttgccaaca gggtaatacg     1020

cttccgtgga cgttcgctgg aggcaccaag ctggaaatca aacggtaa                  1068


<210>  22
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-05-LC nucleotide sequence

<400>  22
cagctcgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcaa      120

cttccaggag cagcccccaa actcctcatc tatggcgaca tcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc atctcagcct ccctggctat cactgggctc      240

caggctgagg acgaggctga ttattactgc cagtcctatg acagcagcct gagtgggggg      300

gtgttcggcg gagggaccaa gctgaccgtc ctaagaaccg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaa         657


<210>  23
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-10-VH amino acid sequence

<400>  23

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
                245                 250                 255     


Glu Leu Val Lys Pro Gly Pro Ser Met Lys Ile Ser Cys Lys Ala Ser 
            260                 265                 270         


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His 
        275                 280                 285             


Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val 
    290                 295                 300                 


Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu 
                325                 330                 335     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser 
            340                 345                 350         


Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe 
        355                 360                 365             


Ser 
    


<210>  24
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-10-VL amino acid sequence

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
                245                 250                 255     


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
            260                 265                 270         


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
        275                 280                 285             


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
    290                 295                 300                 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
305                 310                 315                 320 


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
                325                 330                 335     


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
            340                 345                 350         


Ile Lys Arg 
        355 


<210>  25
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-10-LC amino acid sequence

<400>  25

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  26
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in VH of ACE-10

<400>  26

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H1 of ACE-10

<400>  27

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H2 of ACE-10

<400>  28

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H3 of ACE-10

<400>  29

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10                  


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in VL of ACE-10

<400>  30

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L1 of ACE-10

<400>  31

Ser Ser Val Ser Tyr 
1               5   


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L2 of ACE-10

<400>  32

Ala Thr Ser 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L3 of ACE-10

<400>  33

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  34
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-10-VH nucleotide sequence

<400>  34
caggtgcagc tgcagcagcc tggagccgag ctggtgaagc ccggcgccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gaagcagacc      120

cctggaagag gactggagtg gatcggcgcc atctaccccg gcaacggcga caccagctac      180

aaccagaagt tcaagggcaa ggccaccctg accgccgaca agagcagcag caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc ccgcagcacc      300

tactacggcg gcgactggta cttcaacgtg tggggagctg gaaccaccgt gaccgtgagc      360

gccgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaggttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tgaggtgcag ctccagcagt ctggacctga gctggtgaag      780

cctggacctt caatgaagat atcctgcaag gcttctggtt actcattcac tggctacacc      840

atgaactggg tgaagcagag tcatggaaag aaccttgagt ggatgggact tattaatcct      900

tacaaaggtg ttagtaccta caaccagaag ttcaaggaca aggccacact gactgtagac      960

aagtcatcca gcacagccta catggaactc ctcagtctga catctgagga ctctgcagtc     1020

tattactgtg caagatcggg gtactacggt gatagtgact ggtacttcga tgtctggggc     1080

caggggacca cgctgaccgt cttctcataa                                      1110


<210>  35
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-10-VL nucleotide sequence

<400>  35
caggtgcagc tgcagcagcc tggagccgag ctggtgaagc ccggcgccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gaagcagacc      120

cctggaagag gactggagtg gatcggcgcc atctaccccg gcaacggcga caccagctac      180

aaccagaagt tcaagggcaa ggccaccctg accgccgaca agagcagcag caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc ccgcagcacc      300

tactacggcg gcgactggta cttcaacgtg tggggagctg gaaccaccgt gaccgtgagc      360

gccgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaggttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tgacatccag atgacccaga ccacctcctc cctgtctgcc      780

tccctgggcg acagagtcac catcagttgc agggcaagtc aggacattag aaattattta      840

aactggtatc aacagaaacc agatggaact gttaaactcc tgatctacta cacatcaaga      900

ttacactcag gagtcccatc aaagttcagt ggcagtgggt ctggaacaga ttattctctc      960

accattagca acctggagca agaggatatt gccacttact tttgccaaca gggtaatacg     1020

cttccgtgga cgttcgctgg aggcaccaag ctggaaatca aacggtaa                  1068


<210>  36
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-10-LC nucleotide sequence

<400>  36
cagatcgtgc tgagccagag ccctgctatc ctgagcgcca gccctggcga gaaggtgacc       60

atgacctgcc gcgccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc      120

agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggagt gcctgtgcgc      180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagcagagt ggaggctgag      240

gacgccgcta cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc      300

accaagctgg agatcaagag aaccgtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         642


<210>  37
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-11-VH amino acid sequence

<400>  37

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
                245                 250                 255     


Val Lys Pro Gly Pro Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
            260                 265                 270         


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
        275                 280                 285             


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
    290                 295                 300                 


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
            340                 345                 350         


Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
        355                 360                 365         


<210>  38
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-11-VL amino acid sequence

<400>  38

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
                245                 250                 255     


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
            260                 265                 270         


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
        275                 280                 285             


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
    290                 295                 300                 


Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
305                 310                 315                 320 


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
                325                 330                 335     


Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys 
            340                 345                 350         


Arg 
    


<210>  39
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-11-LC amino acid sequence

<400>  39

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  40
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in VH of ACE-11

<400>  40

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H1 of ACE-11

<400>  41

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H2 of ACE-11

<400>  42

Ile Trp Ser Gly Gly Asn Thr 
1               5           


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR H3 of ACE-11

<400>  43

Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10              


<210>  44
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in VL of ACE-11

<400>  44

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L1 of ACE-11

<400>  45

Gln Ser Ile Gly Thr Asn 
1               5       


<210>  46
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L2 of ACE-11

<400>  46

Tyr Ala Ser 
1           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD20) in CDR L3 of ACE-11

<400>  47

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  48
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-11-VH nucleotide sequence

<400>  48
caagtccaac tgaaacaatc gggtccgggt ctggtccaac cgtcccaatc actgagcatc       60

acctgtaccg tgtcgggctt ctcgctgacc aattatggtg tgcattgggt tcgtcagagt      120

ccgggcaaag gtctggaatg gctgggcgtt atttggtccg gcggtaatac cgattacaac      180

accccgttta cgagtcgcct gtccatcaat aaagacaact cgaaaagcca ggtgtttttc      240

aaaatgaatt cactgcaatc gaacgatacc gcgatttatt actgcgcacg tgctctgacg      300

tattacgact atgaatttgc ctactggggc cagggtaccc tggtgacggt tagcgcggct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcctgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaggt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

ggcggaggtg ggagtgaggt gcagctccag cagtctggac ctgagctggt gaagcctgga      780

ccttcaatga agatatcctg caaggcttct ggttactcat tcactggcta caccatgaac      840

tgggtgaagc agagtcatgg aaagaacctt gagtggatgg gacttattaa tccttacaaa      900

ggtgttagta cctacaacca gaagttcaag gacaaggcca cactgactgt agacaagtca      960

tccagcacag cctacatgga actcctcagt ctgacatctg aggactctgc agtctattac     1020

tgtgcaagat cggggtacta cggtgatagt gactggtact tcgatgtctg gggccagggg     1080

accacgctga ccgtcttctc ataa                                            1104


<210>  49
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-11-VL nucleotide sequence

<400>  49
caagtccaac tgaaacaatc gggtccgggt ctggtccaac cgtcccaatc actgagcatc       60

acctgtaccg tgtcgggctt ctcgctgacc aattatggtg tgcattgggt tcgtcagagt      120

ccgggcaaag gtctggaatg gctgggcgtt atttggtccg gcggtaatac cgattacaac      180

accccgttta cgagtcgcct gtccatcaat aaagacaact cgaaaagcca ggtgtttttc      240

aaaatgaatt cactgcaatc gaacgatacc gcgatttatt actgcgcacg tgctctgacg      300

tattacgact atgaatttgc ctactggggc cagggtaccc tggtgacggt tagcgcggct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcctgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaggt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

ggcggaggtg ggagtgacat ccagatgacc cagaccacct cctccctgtc tgcctccctg      780

ggcgacagag tcaccatcag ttgcagggca agtcaggaca ttagaaatta tttaaactgg      840

tatcaacaga aaccagatgg aactgttaaa ctcctgatct actacacatc aagattacac      900

tcaggagtcc catcaaagtt cagtggcagt gggtctggaa cagattattc tctcaccatt      960

agcaacctgg agcaagagga tattgccact tacttttgcc aacagggtaa tacgcttccg     1020

tggacgttcg ctggaggcac caagctggaa atcaaacggt aa                        1062


<210>  50
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-11-LC nucleotide sequence

<400>  50
gatattctgc tgacccagag cccggtgatc ctgagtgttt ccccgggcga acgtgtgtca       60

ttttcgtgtc gcgcgagcca gtctattggt accaatatcc actggtatca gcaacgtacg      120

aacggctctc cgcgcctgct gattaaatac gccagtgaat ccatttcagg catcccgagc      180

cgcttttcgg gcagcggttc tggcaccgat ttcacgctga gtattaactc cgtggaatca      240

gaagatatcg cagactatta ctgccagcaa aacaataact ggccgaccac gtttggtgct      300

ggcaccaaac tggaactgaa aagaaccgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttaa                      645


<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Her2) in VH of ACE-00

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Her2) in VL of ACE-00

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  53
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (TNF alpha) in VH of ACE-00

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (TNF alpha) in VL of ACE-00

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core hinge region sequence of IgG1

<400>  55

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core hinge region sequence of IgG2

<400>  56

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  57
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core hinge region sequence of IgG3

<400>  57

Glu Leu Lys Thr Pro Leu Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core hinge region sequence of IgG4

<400>  58

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  59
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A representative CL region of the Fab region

<400>  59

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  60
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A representative CH1 region of the Fab region

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  61
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in VH of ACE-02, and ACE-03

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR H1 of ACE-02, and ACE-03

<400>  62

Ser Tyr Trp Met Asn 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR H2 of ACE-02, and ACE-03

<400>  63

Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR H3 of ACE-02, and ACE-03

<400>  64

Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in VL of ACE-02, and ACE-03

<400>  65

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR L1 of ACE-02, and ACE-03

<400>  66

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  67
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR L2 of ACE-02, and ACE-03

<400>  67

Asp Ala Ser 
1           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (CD19) in CDR L3 of ACE-02, and ACE-03

<400>  68

Gln Gln Ser Thr Glu Asp Pro Trp Thr 
1               5                   


<210>  69
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VH of ACE-02

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gln Asp Tyr Asp Val Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H1 of ACE-02

<400>  70

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H2 of ACE-02

<400>  71

Ile Asn Pro Ser Ser Gly Tyr Thr 
1               5               


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H3 of ACE-02

<400>  72

Ala Arg Trp Gln Asp Tyr Asp Val Tyr Phe Asp Tyr 
1               5                   10          


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VL of ACE-02

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L1 of ACE-02

<400>  74

Ser Ser Ser Val Ser Tyr 
1               5       


<210>  75
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L2 of ACE-02

<400>  75

Ala Thr Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L3 of ACE-02

<400>  76

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  77
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VH of ACE-03

<400>  77

Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Val Thr Val Ser Ser 
        115             


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H1 of ACE-03, and ACE-04

<400>  78

Gly Tyr Thr Phe Thr Arg Tyr Thr 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H2 of ACE-03, and ACE-04

<400>  79

Ile Asn Pro Ser Arg Gly Tyr Thr 
1               5               


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR H3 of ACE-03, and ACE-04

<400>  80

Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10          


<210>  81
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VL of ACE-03

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L1 of ACE-03, and ACE-04

<400>  82

Ser Ser Val Ser Tyr 
1               5   


<210>  83
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L2 of ACE-03, and ACE-04

<400>  83

Asp Thr Ser 
1           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L3 of ACE-03

<400>  84

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  85
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VH of ACE-04

<400>  85

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ala 
        115                 


<210>  86
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in VL of ACE-04

<400>  86

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (CD3) in CDR L3 of ACE-04

<400>  87

Gln Gln Trp Ser Ser Asn Pro Phe 
1               5               


<210>  88
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-02-VH amino acid sequence

<400>  88

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
                245                 250                 255     


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
            260                 265                 270         


Thr Phe Thr Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys 
    290                 295                 300                 


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser 
305                 310                 315                 320 


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
                325                 330                 335     


Gly Val Tyr Phe Cys Ala Arg Trp Gln Asp Tyr Asp Val Tyr Phe Asp 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360                 


<210>  89
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-02-VL amino acid sequence

<400>  89

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                245                 250                 255     


Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser 
            260                 265                 270         


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro 
        275                 280                 285             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser 
    290                 295                 300                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
305                 310                 315                 320 


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                325                 330                 335     


Ser Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            340                 345                 350         


<210>  90
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-02-LC, ACE-03-LC (anti-CD19 antibody light chain)

<400>  90

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  91
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-03-VH amino acid sequence

<400>  91

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Val Gln Leu Val Gln Ser Gly Gly Gly Val Val 
                245                 250                 255     


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
            260                 265                 270         


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        275                 280                 285             


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
    290                 295                 300                 


Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys 
305                 310                 315                 320 


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
            340                 345                 350         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360             


<210>  92
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-03-VL amino acid sequence

<400>  92

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                245                 250                 255     


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
            260                 265                 270         


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro 
        275                 280                 285             


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
    290                 295                 300                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
305                 310                 315                 320 


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                325                 330                 335     


Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            340                 345                 350         


<210>  93
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-04-VH amino acid seqeunce

<400>  93

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala 
                245                 250                 255     


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
            260                 265                 270         


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro 
        275                 280                 285             


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
    290                 295                 300                 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp 
305                 310                 315                 320 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                325                 330                 335     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
            340                 345                 350         


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser 
        355                 360                 365             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    450                 455                 460                 


Glu Pro Lys Ser Cys 
465                 


<210>  94
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-04-VL amino acid sequence

<400>  94

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
                245                 250                 255     


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
            260                 265                 270         


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
        275                 280                 285             


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
    290                 295                 300                 


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
305                 310                 315                 320 


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                325                 330                 335     


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            340                 345                 350         


Asn Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        355                 360                 365             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    370                 375                 380                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
385                 390                 395                 400 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                405                 410                 415     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            420                 425                 430         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        435                 440                 445             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460 


<210>  95
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-04-LC, ACE-09-LC, and ACE-12-LC (anti-PD-L1 antibody light 
       chain)

<400>  95

Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ile Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg 
            100                 105                 110         


Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  96
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-09-VH amino acid sequence (without G4S linker)

<400>  96

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
                245                 250                 255     


Gly Pro Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            260                 265                 270         


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu 
        275                 280                 285             


Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln 
    290                 295                 300                 


Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
305                 310                 315                 320 


Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
            340                 345                 350         


Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
        355                 360                 


<210>  97
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-09-VL amino acid sequence (without G4S linker)

<400>  97

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
                245                 250                 255     


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            260                 265                 270         


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        275                 280                 285             


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
305                 310                 315                 320 


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                325                 330                 335     


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            340                 345                 350 


<210>  98
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-12-VH amino acid sequence (with 10 residues)

<400>  98

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                245                 250                 255     


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Pro Ser Met Lys Ile 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
        275                 280                 285             


Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn 
    290                 295                 300                 


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
305                 310                 315                 320 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu 
                325                 330                 335     


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
            340                 345                 350         


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Leu Thr Val Phe Ser 
    370                 


<210>  99
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-12-VL amino acid sequence (with 9 residues)

<400>  99

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Arg Asp Gly Tyr Asn Leu Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Gln Met Thr 
                245                 250                 255     


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
            260                 265                 270         


Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
        275                 280                 285             


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
    290                 295                 300                 


Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr 
305                 310                 315                 320 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
                325                 330                 335     


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly 
            340                 345                 350         


Thr Lys Leu Glu Ile Lys Arg 
        355                 


<210>  100
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-02-VH nucleotide sequence

<400>  100
caggttcaat tgcagcaaag cggggctgag ttggtacggc ctgggtccag cgtgaagata       60

tcatgtaagg cttctggata tgccttctcc tcttactgga tgaactgggt caagcaacgg      120

ccaggacaag gcctggagtg gattgggcaa atatggcccg gggacggaga tactaattat      180

aatggcaagt ttaaggggaa agctacactg accgcagacg aaagctcctc tacggcctat      240

atgcagctct catctcttgc gtccgaagat agtgcagtat atttttgtgc gcgccgcgag      300

accaccacgg ttgggaggta ctattacgcg atggattact ggggccaggg gactacagtt      360

acggtttcat cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcctg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccgcaggt gcagctggtg cagagcggcg gcggcgtggt gcagcccggc      780

cgcagcctgc gcctgagctg caaggccagc ggctacacct tcaccagcta caccatgcac      840

tgggtgcgcc aggcccccgg caagggcctg gagtggatcg gctacatcaa ccccagcagc      900

ggctacacca agtacaacca gaagttcaag gaccgcttca ccatcagcgc cgacaagagc      960

aagagcaccg ccttcctgca gatggacagc ctgcgccccg aggacaccgg cgtgtacttc     1020

tgcgcccgct ggcaggacta cgacgtgtac ttcgactact ggggccaggg cacccccgtg     1080

accgtgagca gctaa                                                      1095


<210>  101
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-02-VL nucleotide sequence

<400>  101
caggttcaat tgcagcaaag cggggctgag ttggtacggc ctgggtccag cgtgaagata       60

tcatgtaagg cttctggata tgccttctcc tcttactgga tgaactgggt caagcaacgg      120

ccaggacaag gcctggagtg gattgggcaa atatggcccg gggacggaga tactaattat      180

aatggcaagt ttaaggggaa agctacactg accgcagacg aaagctcctc tacggcctat      240

atgcagctct catctcttgc gtccgaagat agtgcagtat atttttgtgc gcgccgcgag      300

accaccacgg ttgggaggta ctattacgcg atggattact ggggccaggg gactacagtt      360

acggtttcat cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcctg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccggacat ccagatgacc cagagcccca gcagcctgag cgccagcgtg      780

ggcgaccgcg tgaccatgac ctgccgcgcc agcagcagcg tgagctacat gcactggtac      840

cagcagaccc ccggcaaggc ccccaagccc tggatctacg ccaccagcaa cctggccagc      900

ggcgtgccca gccgcttcag cggcagcggc agcggcaccg actacaccct gaccatcagc      960

agcctgcagc ccgaggacat cgccacctac tactgccagc agtggagcag caaccccccc     1020

accttcggcc agggcaccaa gctgcagatc acccgctaa                            1059


<210>  102
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-02-LC, and ACE-03-LC (anti-CD19 antibody light chain 
       nucleotide sequence)

<400>  102
gatattcaac tcacgcaatc tccagcaagt ctcgcagtta gtttggggca gcgagctaca       60

ataagttgca aggcgagcca atccgtggat tatgatggag acagctatct taactggtat      120

cagcaaattc caggccagcc acccaagttg ctgatctacg acgcgtcaaa cctggtctca      180

gggatccctc caagatttag cggctcaggt tcaggtacgg attttacgct caatatccat      240

cctgtagaga aggttgatgc agctacatac cactgtcaac agagtaccga ggatccttgg      300

accttcggag gcggtacaaa gctggagatc aagagaaccg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaa         657


<210>  103
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-03-VH nucleotide sequence

<400>  103
caggttcaat tgcagcaaag cggggctgag ttggtacggc ctgggtccag cgtgaagata       60

tcatgtaagg cttctggata tgccttctcc tcttactgga tgaactgggt caagcaacgg      120

ccaggacaag gcctggagtg gattgggcaa atatggcccg gggacggaga tactaattat      180

aatggcaagt ttaaggggaa agctacactg accgcagacg aaagctcctc tacggcctat      240

atgcagctct catctcttgc gtccgaagat agtgcagtat atttttgtgc gcgccgcgag      300

accaccacgg ttgggaggta ctattacgcg atggattact ggggccaggg gactacagtt      360

acggtttcat cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcctg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccggtgca gctggtgcag agcggcggcg gcgtggtgca gcccggccgc      780

agcctgcgcc tgagctgcaa ggccagcggc tacaccttca cccgctacac catgcactgg      840

gtgcgccagg cccccggcaa gggcctggag tggatcggct acatcaaccc cagccgcggc      900

tacaccaact acaaccagaa ggtgaaggac cgcttcacca tcagcaccga caagagcaag      960

agcaccgcct tcctgcagat ggacagcctg cgccccgagg acaccgccgt gtactactgc     1020

gcccgctact acgacgacca ctactgcctg gactactggg gccagggcac ccccgtgacc     1080

gtgagcagct aa                                                         1092


<210>  104
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-03-VL nucleotide sequence

<400>  104
caggttcaat tgcagcaaag cggggctgag ttggtacggc ctgggtccag cgtgaagata       60

tcatgtaagg cttctggata tgccttctcc tcttactgga tgaactgggt caagcaacgg      120

ccaggacaag gcctggagtg gattgggcaa atatggcccg gggacggaga tactaattat      180

aatggcaagt ttaaggggaa agctacactg accgcagacg aaagctcctc tacggcctat      240

atgcagctct catctcttgc gtccgaagat agtgcagtat atttttgtgc gcgccgcgag      300

accaccacgg ttgggaggta ctattacgcg atggattact ggggccaggg gactacagtt      360

acggtttcat cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcctg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccggacat ccagatgacc cagagcccca gcagcctgag cgccagcgtg      780

ggcgaccgcg tgaccatcac ctgcagcgcc agcagcagcg tgagctacat gaactggtac      840

cagcagaccc ccggcaaggc ccccaagcgc tggatctacg acaccagcaa gctggccagc      900

ggcgtgccca gccgcttcag cggcagcggc agcggcaccg actacacctt caccatcagc      960

agcctgcagc ccgaggacat cgccacctac tactgccagc agtggagcag caaccccttc     1020

accttcggcc agggcaccaa gctgcagatc acccgctaa                            1059


<210>  105
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-04-VH nucleotide seqeunce

<400>  105
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tcaggtccag ttgcaacagt ctggagccga gctcgccagg      780

ccaggagcct ccgtcaaaat gtcatgcaag gcctcagggt acacatttac gcgatatacc      840

atgcactggg tgaaacaaag accaggtcag ggacttgaat ggatcggtta cattaacccc      900

tctagaggct atacgaatta caaccagaaa ttcaaagaca aagcaacact tacgactgac      960

aaatccagta gtacggctta catgcagctc tcatctttga cttcagaaga ctctgctgta     1020

tattattgtg cccgctatta cgatgaccat tactgccttg attactgggg ccagggcact     1080

actgttaccg taagtgcggc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc     1140

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     1200

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     1260

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     1320

agcctgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg     1380

gacaagagag ttgagcccaa atcttgttga                                      1410


<210>  106
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-04-VL nucleotide sequence

<400>  106
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tcagatcgtc ctcactcaaa gtcctgctat tatgtccgca      780

agccctggtg aaaaggttac catgacttgc tccgcatcta gttctgtctc ttacatgaac      840

tggtaccagc aaaagtctgg aacgtccccg aaaaggtgga tatatgatac gagcaaattg      900

gcaagcggag tacccgcgca ttttaggggt tcaggcagcg gtacgtcata tagcctgact      960

attagcggaa tggaggcgga ggatgctgca acatattatt gccaacaatg gtcatcaaat     1020

ccttttactt tcggctcagg cacaaaactt gaaataaata gaaccgtggc tgcaccatct     1080

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     1140

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     1200

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     1260

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     1320

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     1380

taa                                                                   1383


<210>  107
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-04-LC, ACE-09-LC, ACE-12-LC (anti-PD-L1 antibody light chain 
       nucleotide sequence)

<400>  107
cagctcgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcaa      120

cttccaggag cagcccccaa actcctcatc tatggcgaca tcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc atctcagcct ccctggctat cactgggctc      240

caggctgagg acgaggctga ttattactgc cagtcctatg acagcagcct gagtgggggg      300

gtgttcggcg gagggaccaa gctgaccgtc ctaagatctg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag         657


<210>  108
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-09-VH nucleotide sequence (without G4S linker)

<400>  108
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccggagg tgcagctcca gcagtctgga cctgagctgg tgaagcctgg accttcaatg      780

aagatatcct gcaaggcttc tggttactca ttcactggct acaccatgaa ctgggtgaag      840

cagagtcatg gaaagaacct tgagtggatg ggacttatta atccttacaa aggtgttagt      900

acctacaacc agaagttcaa ggacaaggcc acactgactg tagacaagtc atccagcaca      960

gcctacatgg aactcctcag tctgacatct gaggactctg cagtctatta ctgtgcaaga     1020

tcggggtact acggtgatag tgactggtac ttcgatgtct ggggccaggg gaccacgctg     1080

accgtcttct cataa                                                      1095


<210>  109
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-09-VL nucleotide sequence (without G4S linker)

<400>  109
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccggaca tccagatgac ccagaccacc tcctccctgt ctgcctccct gggcgacaga      780

gtcaccatca gttgcagggc aagtcaggac attagaaatt atttaaactg gtatcaacag      840

aaaccagatg gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc      900

ccatcaaagt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      960

gagcaagagg atattgccac ttacttttgc caacagggta atacgcttcc gtggacgttc     1020

gctggaggca ccaagctgga aatcaaacgg taa                                  1053


<210>  110
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-12-VH nucleotide sequence (with 10 residues)

<400>  110
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gaggtgggag tggaggcgga ggatctgagg tgcagctcca gcagtctgga      780

cctgagctgg tgaagcctgg accttcaatg aagatatcct gcaaggcttc tggttactca      840

ttcactggct acaccatgaa ctgggtgaag cagagtcatg gaaagaacct tgagtggatg      900

ggacttatta atccttacaa aggtgttagt acctacaacc agaagttcaa ggacaaggcc      960

acactgactg tagacaagtc atccagcaca gcctacatgg aactcctcag tctgacatct     1020

gaggactctg cagtctatta ctgtgcaaga tcggggtact acggtgatag tgactggtac     1080

ttcgatgtct ggggccaggg gaccacgctg accgtcttct cataa                     1125


<210>  111
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE-12-VL nucleotide sequence (with 9 residues)

<400>  111
cagatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaaaccgaga      300

gatggctaca atttggttgc ttttgatatc tggggccaag ggacgatggt caccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgggcg gatccggcgg aggcggcagc ggagacatcc agatgaccca gaccacctcc      780

tccctgtctg cctccctggg cgacagagtc accatcagtt gcagggcaag tcaggacatt      840

agaaattatt taaactggta tcaacagaaa ccagatggaa ctgttaaact cctgatctac      900

tacacatcaa gattacactc aggagtccca tcaaagttca gtggcagtgg gtctggaaca      960

gattattctc tcaccattag caacctggag caagaggata ttgccactta cttttgccaa     1020

cagggtaata cgcttccgtg gacgttcgct ggaggcacca agctggaaat caaacggtaa     1080


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker in ACE-05-VH and ACE-05-VL

<400>  112

Gly Gly Gly Gly Ser 
1               5   


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker in ACE-12-VH

<400>  113

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker in ACE-12-VL

<400>  114

Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   


<210>  115
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-00-VH amino acid sequence

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                245                 250                 255     


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            260                 265                 270         


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        275                 280                 285             


Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser 
    290                 295                 300                 


Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360         


<210>  116
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-00-VL amino acid sequence

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                245                 250                 255     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
            260                 265                 270         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
305                 310                 315                 320 


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro 
                325                 330                 335     


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            340                 345                 


<210>  117
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-00-LC amino acid sequence (anti-CD19 antibody light chain)

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR H1 of ACE-00

<400>  118

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR H2 of ACE-00

<400>  119

Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               


<210>  120
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR H3 of ACE-00

<400>  120

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR L1 of ACE-00

<400>  121

Gln Asp Val Asn Thr Ala 
1               5       


<210>  122
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR L2 of ACE-00

<400>  122

Ser Ala Ser 
1           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab region (Anti-Her2) in CDR L3 of ACE-00

<400>  123

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR H1 of ACE-00

<400>  124

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR H2 of ACE-00

<400>  125

Ile Thr Trp Asn Ser Gly His Ile 
1               5               


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR H3 of ACE-00

<400>  126

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10                  


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR L1 of ACE-00

<400>  127

Gln Gly Ile Arg Asn Tyr 
1               5       


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR L2 of ACE-00

<400>  128

Ala Ala Ser 
1           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fv region (Anti-TNF alpha) in CDR L3 of ACE-00

<400>  129

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


