                         SEQUENCE LISTING

<110>  Ludwig Institute for Cancer Research Ltd.
       cole Polytechnique Fdrale de Lausanne
 
<120>  HETERODIMERIC INACTIVATABLE CHIMERIC ANTIGEN RECEPTORS

<130>  252457.000006

<150>  62/657,534
<151>  2018-04-13

<150>  62/832,767
<151>  2019-04-11

<160>  178   

<170>  PatentIn version 3.5

<210>  1
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  1

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala Ala 
    130                 135                 140                 


Glu 
145 


<210>  2
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  2

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140             


<210>  3
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  3

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140             


<210>  4
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  4

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Ala 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140             


<210>  5
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homos sapiens

<400>  5

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln 
        35                  40                  45              


Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala 
    50                  55                  60                  


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
65                  70                  75                  80  


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
            100                 105                 110         


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
        115                 120                 125             


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
    130                 135                 140                 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
145                 150                 155                 160 


Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp 
                165                 170     


<210>  6
<211>  237
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  6

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg 
225                 230                 235         


<210>  7
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  7

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  8
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  8

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  30  


<210>  9
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  9

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  10
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  10

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  11
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  13
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  13

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  14
<211>  1698
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  14
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc agtgaggata      120

tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt gaagcagagc      180

catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg taccacctac      240

aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag tacagcctac      300

atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc agctggttgg      360

aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg aggtggatca      420

ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc tcacaaattc      480

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt      540

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg      600

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac      660

ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt ctgtcagcaa      720

tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa acgggctagc      780

acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg      840

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      900

gatttcgcct gcgacttctg ggtgctggtg gtcgtgggcg gagtgctggc ctgttacagc      960

ctgctcgtga ccgtggcctt catcatcttt tgggtgcgga gcaagagaag cagactgctg     1020

cacagcgact acatgaacat gacccccaga cggcctggcc ccaccagaaa gcactaccag     1080

ccttacgccc ctcccagaga cttcgccgcc tacagatctc atatgggagg cggaggatct     1140

ggcggaggtg gaagtggcgg aggcggatct caaagatggg aactcgccct gggcagattc     1200

ctggaatacc tgagctgggt gtccacactg agcgaacagg tgcaagagga actgctgagc     1260

agccaagtga cccaagagct gagagccctg atggacgaga caatgaagga actgaaggcc     1320

tacaagagcg agctggaaga acagctgacc cctgtggccg aggaaaccag agccagactg     1380

agcaaagaac tgcaggccgc tcaggccaga ctgggagccg atatggaaga tgttcggggc     1440

agactggtgc agtacagagg cgaagttcag gccatgctgg gccagtctac cgaggaactg     1500

agagtgcggc tggcctctca tctgattgcc ctgcagctga gactgatcgg cgacgcattc     1560

gacctgcaga aaagactggc cgtgtaccag gctggcgctg ctgaacggaa gcggcgcagc     1620

ggcagcgggc gcagcggcag cggcgagggc agaggaagtc ttctaacatg cggtgacgtg     1680

gaggagaatc ccggccct                                                   1698


<210>  15
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  15
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgaccctagg ttctgggtgc tggtggtcgt gggcggagtg      360

ctggcctgtt acagcctgct cgtgaccgtg gccttcatca tcttttgggt gcggagcaag      420

agaagcagac tgctgcacag cgactacatg aacatgaccc ccagacggcc tggccccacc      480

agaaagcact accagcctta cgcccctccc agagacttcg ccgcctacag atctcccggg      540

ggaggcggag gatctggcgg aggtggaagt ggcggaggcg gatctatgag ccagagcaac      600

agagaactgg tggtggactt cctgagctac aagctgagcc agaagggcta cagctggtcc      660

cagttcagcg acgtggaaga gaacagaaca gaggcccctg agggcacaga gtctgaggct      720

gtgaaacagg ccctgagaga agccggcgac gagttcgagc tgagatacag aagggccttc      780

agcgacctga ccagccagct gcacatcaca cctggcacag cctaccagag cttcgagcag      840

gtcgtgaacg agctgttcag agatggcgtg aactggggca gaatcgtggc cttcttcagc      900

tttggcggag ccctgtgtgt ggaaagcgtg gacaaagaaa tgcaggtcct ggtgtccaga      960

atcgccgcct ggatggccac ctacctgaac gatcatctgg aaccctggat tcaagagaac     1020

ggcggctggg acaccttcgt ggaactgtac ggaaacaacg ccgctgccga gagcagaaag     1080

ggccaagaac gagaagatgg cggcggtggt tctggtggcg gcggtagtgg tggcggtgga     1140

tcaatgcata gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1200

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1260

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1320

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1380

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1440

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  1488


<210>  16
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  17
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  18
<211>  10913
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  18
gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg       60

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc      120

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg      180

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat      240

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg      300

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg      360

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc      420

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt      480

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct      540

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc      600

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca      660

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct      720

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt      780

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga      840

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca      900

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac      960

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     1020

taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag     1080

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     1140

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     1200

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     1260

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     1320

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     1380

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     1440

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     1500

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     1560

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     1620

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     1680

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     1740

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc     1800

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa     1860

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagcgcg     1920

caattaaccc tcactaaagg gaacaaaagc tggagctgca agcttaatgt agtcttatgc     1980

aatactcttg tagtcttgca acatggtaac gatgagttag caacatgcct tacaaggaga     2040

gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg tacgatcgtg ccttattagg     2100

aaggcaacag acgggtctga catggattgg acgaaccact gaattgccgc attgcagaga     2160

tattgtattt aagtgcctag ctcgatacaa taaacgggtc tctctggtta gaccagatct     2220

gagcctggga gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc     2280

cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc     2340

tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca gggacctgaa     2400

agcgaaaggg aaaccagagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc     2460

aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa     2520

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga     2580

aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc     2640

aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg     2700

tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc     2760

attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac     2820

caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca     2880

agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat     2940

tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga     3000

gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct     3060

tgggagcagc aggaagcact atgggcgcag cctcaatgac gctgacggta caggccagac     3120

aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac     3180

agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg     3240

tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca     3300

tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattg     3360

gaatcacacg acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca     3420

ctccttaatt gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt     3480

agataaatgg gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa     3540

attattcata atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc     3600

tatagtgaat agagttaggc agggatattc accattatcg tttcagaccc acctcccaac     3660

cccgagggga cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga     3720

cagatccatt cgattagtga acggatctcg acggtatcga ttagactgta gcccaggaat     3780

atggcagcta gattgtacac atttagaagg aaaagttatc ttggtagcag ttcatgtagc     3840

cagtggatat atagaagcag aagtaattcc agcagagaca gggcaagaaa cagcatactt     3900

cctcttaaaa ttagcaggaa gatggccagt aaaaacagta catacagaca atggcagcaa     3960

tttcaccagt actacagtta aggccgcctg ttggtgggcg gggatcaagc aggaatttgg     4020

cattccctac aatccccaaa gtcaaggagt aatagaatct atgaataaag aattaaagaa     4080

aattatagga caggtaagag atcaggctga acatcttaag acagcagtac aaatggcagt     4140

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     4200

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     4260

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggctgc atacgcgtcg     4320

tgaggctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg     4380

gggggagggg tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa     4440

agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt     4500

gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acaggtaagt     4560

gccgtgtgtg gttcccgcgg gcctggcctc tttacgggtt atggcccttg cgtgccttga     4620

attacttcca cctggctgca gtacgtgatt cttgatcccg agcttcgggt tggaagtggg     4680

tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc     4740

tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct     4800

gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac gctttttttc     4860

tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg     4920

gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg     4980

cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg     5040

cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca     5100

ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag ctcaaaatgg     5160

aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt     5220

ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc     5280

gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg     5340

atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg     5400

taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct caagcctcag     5460

acagtggttc aaagtttttt tcttccattt caggtgtcgt gagctagacg actagtcgtc     5520

tagctctaga atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     5580

cgccgccagg ccggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc     5640

agtgaggata tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt     5700

gaagcagagc catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg     5760

taccacctac aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag     5820

tacagcctac atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc     5880

agctggttgg aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg     5940

aggtggatca ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc     6000

tcacaaattc atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca     6060

agatgtgggt actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact     6120

gatttattgg gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc     6180

tgggacagac ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt     6240

ctgtcagcaa tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa     6300

acgggctagc acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag     6360

ccagcctctg agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac     6420

cagaggactg gatttcgcct gcgacttctg ggtgctggtg gtcgtgggcg gagtgctggc     6480

ctgttacagc ctgctcgtga ccgtggcctt catcatcttt tgggtgcgga gcaagagaag     6540

cagactgctg cacagcgact acatgaacat gacccccaga cggcctggcc ccaccagaaa     6600

gcactaccag ccttacgccc ctcccagaga cttcgccgcc tacagatctc atatgggagg     6660

cggaggatct ggcggaggtg gaagtggcgg aggcggatct caaagatggg aactcgccct     6720

gggcagattc ctggaatacc tgagctgggt gtccacactg agcgaacagg tgcaagagga     6780

actgctgagc agccaagtga cccaagagct gagagccctg atggacgaga caatgaagga     6840

actgaaggcc tacaagagcg agctggaaga acagctgacc cctgtggccg aggaaaccag     6900

agccagactg agcaaagaac tgcaggccgc tcaggccaga ctgggagccg atatggaaga     6960

tgttcggggc agactggtgc agtacagagg cgaagttcag gccatgctgg gccagtctac     7020

cgaggaactg agagtgcggc tggcctctca tctgattgcc ctgcagctga gactgatcgg     7080

cgacgcattc gacctgcaga aaagactggc cgtgtaccag gctggcgctg ctgaacggaa     7140

gcggcgcagc ggcagcgggc gcagcggcag cggcgagggc agaggaagtc ttctaacatg     7200

cggtgacgtg gaggagaatc ccggccctgg atccatggcc ttaccagtga ccgccttgct     7260

cctgccgctg gccttgctgc tccacgccgc caggccggaa cagaaactca tcagtgagga     7320

agatttgcag acgactccag gagagagatc atcactccct gccttttacc ctggcacttc     7380

aggctcttgt tccggatgtg ggtccctctc tctgccgaca acaacccctg cccccagacc     7440

tcctacccca gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag     7500

acctgctgct ggcggagccg tgcacaccag aggactggat ttcgcctgcg accctaggtt     7560

ctgggtgctg gtggtcgtgg gcggagtgct ggcctgttac agcctgctcg tgaccgtggc     7620

cttcatcatc ttttgggtgc ggagcaagag aagcagactg ctgcacagcg actacatgaa     7680

catgaccccc agacggcctg gccccaccag aaagcactac cagccttacg cccctcccag     7740

agacttcgcc gcctacagat ctcccggggg aggcggagga tctggcggag gtggaagtgg     7800

cggaggcgga tctatgagcc agagcaacag agaactggtg gtggacttcc tgagctacaa     7860

gctgagccag aagggctaca gctggtccca gttcagcgac gtggaagaga acagaacaga     7920

ggcccctgag ggcacagagt ctgaggctgt gaaacaggcc ctgagagaag ccggcgacga     7980

gttcgagctg agatacagaa gggccttcag cgacctgacc agccagctgc acatcacacc     8040

tggcacagcc taccagagct tcgagcaggt cgtgaacgag ctgttcagag atggcgtgaa     8100

ctggggcaga atcgtggcct tcttcagctt tggcggagcc ctgtgtgtgg aaagcgtgga     8160

caaagaaatg caggtcctgg tgtccagaat cgccgcctgg atggccacct acctgaacga     8220

tcatctggaa ccctggattc aagagaacgg cggctgggac accttcgtgg aactgtacgg     8280

aaacaacgcc gctgccgaga gcagaaaggg ccaagaacga gaagatggcg gcggtggttc     8340

tggtggcggc ggtagtggtg gcggtggatc aatgcataga gtgaagttca gcaggagcgc     8400

agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg     8460

aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa     8520

gccgagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc     8580

ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg     8640

cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc     8700

cctgccccct cgctaagtcg acaatcaacc tctggattac aaaatttgtg aaagattgac     8760

tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt     8820

gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt     8880

gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt     8940

gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg     9000

gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg     9060

ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct     9120

gacgtccttt ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt     9180

ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc     9240

tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc     9300

cgcctccccg cctggaattc gagctcggta cctttaagac caatgactta caaggcagct     9360

gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa     9420

cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc     9480

tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga     9540

gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga     9600

cccttttagt cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag     9660

tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct     9720

tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca     9780

ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag     9840

ctatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt     9900

tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag aagtagtgag     9960

gaggcttttt tggaggccta gctaggcttt tgcgtcgaga cgtacccaat tcgccctata    10020

gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc    10080

ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata    10140

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc    10200

gcgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga    10260

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg    10320

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat    10380

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg    10440

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata    10500

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt    10560

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat    10620

ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc ccaggtggca cttttcgggg    10680

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct    10740

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat    10800

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc    10860

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cac           10913


<210>  19
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  19

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140             


<210>  20
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  20
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  21
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  21
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  22
<211>  169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  22

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln 
        35                  40                  45              


Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala 
    50                  55                  60                  


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
65                  70                  75                  80  


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
            100                 105                 110         


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
        115                 120                 125             


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
    130                 135                 140                 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
145                 150                 155                 160 


Ala Glu Ser Arg Lys Gly Gln Glu Arg 
                165                 


<210>  23
<211>  169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  23

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln 
        35                  40                  45              


Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala 
    50                  55                  60                  


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
65                  70                  75                  80  


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
            100                 105                 110         


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
        115                 120                 125             


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
    130                 135                 140                 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
145                 150                 155                 160 


Ala Glu Ser Arg Lys Gly Gln Glu Arg 
                165                 


<210>  24
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  24

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg 
        195                 200                 205         


<210>  25
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  26
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide: serine/glycine linker

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  27
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  27

Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25                  30      


<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  c-myc tag

<400>  28

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  29
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  29

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  30
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  30

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln 
        35                  40                  45              


Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala 
    50                  55                  60                  


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
65                  70                  75                  80  


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
            100                 105                 110         


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
        115                 120                 125             


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
    130                 135                 140                 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
145                 150                 155                 160 


Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp 
                165                 170     


<210>  31
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  31

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala Ala 
    130                 135                 140                 


Glu 
145 


<210>  32
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  32

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly Asp 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala Ala 
    130                 135                 140                 


Glu 
145 


<210>  33
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  33

Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser Trp 
1               5                   10                  15      


Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser Gln 
            20                  25                  30          


Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu Leu 
        35                  40                  45              


Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu 
    50                  55                  60                  


Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr Arg 
                85                  90                  95      


Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val 
            100                 105                 110         


Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly Ala 
        115                 120                 125             


Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala Ala 
    130                 135                 140                 


Glu 
145 


<210>  34
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  34

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg 
        195                 200                 205         


<210>  35
<211>  1061
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    930                 935                 940                 


Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
945                 950                 955                 960 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                965                 970                 975     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            980                 985                 990         


Glu Met Gly Gly Lys Pro Arg Arg  Lys Asn Pro Gln Glu  Gly Leu Tyr 
        995                 1000                 1005             


Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu Ala Tyr  Ser Glu Ile 
    1010                 1015                 1020             


Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys Gly His  Asp Gly Leu 
    1025                 1030                 1035             


Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp Thr Tyr  Asp Ala Leu 
    1040                 1045                 1050             


His Met  Gln Ala Leu Pro Pro  Arg 
    1055                 1060     


<210>  36
<211>  1061
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    930                 935                 940                 


Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
945                 950                 955                 960 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                965                 970                 975     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            980                 985                 990         


Glu Met Gly Gly Lys Pro Arg Arg  Lys Asn Pro Gln Glu  Gly Leu Tyr 
        995                 1000                 1005             


Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu Ala Tyr  Ser Glu Ile 
    1010                 1015                 1020             


Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys Gly His  Asp Gly Leu 
    1025                 1030                 1035             


Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp Thr Tyr  Asp Ala Leu 
    1040                 1045                 1050             


His Met  Gln Ala Leu Pro Pro  Arg 
    1055                 1060     


<210>  37
<211>  1097
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala Gly Arg Thr 
        755                 760                 765             


Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His Tyr Lys Leu 
    770                 775                 780                 


Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly Ala Ala Pro 
785                 790                 795                 800 


Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly His 
                805                 810                 815     


Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg Thr Ser Pro 
            820                 825                 830         


Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser 
        835                 840                 845             


Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala Gly Asp Asp 
    850                 855                 860                 


Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser Ser Gln Leu 
865                 870                 875                 880 


His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr Val Val Glu 
                885                 890                 895     


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
            900                 905                 910         


Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg Glu Met Ser 
        915                 920                 925             


Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg 
    930                 935                 940                 


His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe Val 
945                 950                 955                 960 


Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser 
            980                 985                 990         


Ala Asp Ala Pro Ala Tyr Gln Gln  Gly Gln Asn Gln Leu  Tyr Asn Glu 
        995                 1000                 1005             


Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp Val Leu  Asp Lys Arg 
    1010                 1015                 1020             


Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys Pro Arg  Arg Lys Asn 
    1025                 1030                 1035             


Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala 
    1040                 1045                 1050             


Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly 
    1055                 1060                 1065             


Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys 
    1070                 1075                 1080             


Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1085                 1090                 1095         


<210>  38
<211>  1062
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Ala Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg 
        755                 760                 765             


Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr 
    770                 775                 780                 


Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro 
785                 790                 795                 800 


Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly 
                805                 810                 815     


Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser 
            820                 825                 830         


Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val 
        835                 840                 845             


Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala 
    850                 855                 860                 


Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu 
865                 870                 875                 880 


Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu 
                885                 890                 895     


Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr 
            900                 905                 910         


Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly 
        915                 920                 925             


Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
945                 950                 955                 960 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                965                 970                 975     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            980                 985                 990         


Pro Glu Met Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
        995                 1000                 1005             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1010                 1015                 1020             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1025                 1030                 1035             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1040                 1045                 1050             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1055                 1060         


<210>  39
<211>  1062
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg 
        755                 760                 765             


Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr 
    770                 775                 780                 


Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro 
785                 790                 795                 800 


Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly 
                805                 810                 815     


Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser 
            820                 825                 830         


Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val 
        835                 840                 845             


Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala 
    850                 855                 860                 


Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu 
865                 870                 875                 880 


Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu 
                885                 890                 895     


Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr 
            900                 905                 910         


Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly 
        915                 920                 925             


Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
945                 950                 955                 960 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                965                 970                 975     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            980                 985                 990         


Pro Glu Met Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
        995                 1000                 1005             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1010                 1015                 1020             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1025                 1030                 1035             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1040                 1045                 1050             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1055                 1060         


<210>  40
<211>  1062
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg 
        755                 760                 765             


Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr 
    770                 775                 780                 


Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro 
785                 790                 795                 800 


Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly 
                805                 810                 815     


Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser 
            820                 825                 830         


Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val 
        835                 840                 845             


Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala 
    850                 855                 860                 


Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu 
865                 870                 875                 880 


Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu 
                885                 890                 895     


Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr 
            900                 905                 910         


Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly 
        915                 920                 925             


Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
945                 950                 955                 960 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                965                 970                 975     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            980                 985                 990         


Pro Glu Met Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
        995                 1000                 1005             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1010                 1015                 1020             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1025                 1030                 1035             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1040                 1045                 1050             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1055                 1060         


<210>  41
<211>  1098
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Ala Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala Gly Arg 
        755                 760                 765             


Thr Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His Tyr Lys 
    770                 775                 780                 


Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly Ala Ala 
785                 790                 795                 800 


Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly 
                805                 810                 815     


His Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg Thr Ser 
            820                 825                 830         


Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu 
        835                 840                 845             


Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala Gly Asp 
    850                 855                 860                 


Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser Ser Gln 
865                 870                 875                 880 


Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr Val Val 
                885                 890                 895     


Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
            900                 905                 910         


Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg Glu Met 
        915                 920                 925             


Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn 
    930                 935                 940                 


Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe 
945                 950                 955                 960 


Val Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg 
            980                 985                 990         


Ser Ala Asp Ala Pro Ala Tyr Gln  Gln Gly Gln Asn Gln  Leu Tyr Asn 
        995                 1000                 1005             


Glu Leu  Asn Leu Gly Arg Arg  Glu Glu Tyr Asp Val  Leu Asp Lys 
    1010                 1015                 1020             


Arg Arg  Gly Arg Asp Pro Glu  Met Gly Gly Lys Pro  Arg Arg Lys 
    1025                 1030                 1035             


Asn Pro  Gln Glu Gly Leu Tyr  Asn Glu Leu Gln Lys  Asp Lys Met 
    1040                 1045                 1050             


Ala Glu  Ala Tyr Ser Glu Ile  Gly Met Lys Gly Glu  Arg Arg Arg 
    1055                 1060                 1065             


Gly Lys  Gly His Asp Gly Leu  Tyr Gln Gly Leu Ser  Thr Ala Thr 
    1070                 1075                 1080             


Lys Asp  Thr Tyr Asp Ala Leu  His Met Gln Ala Leu  Pro Pro Arg 
    1085                 1090                 1095             


<210>  42
<211>  1098
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala Gly Arg 
        755                 760                 765             


Thr Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His Tyr Lys 
    770                 775                 780                 


Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly Ala Ala 
785                 790                 795                 800 


Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly 
                805                 810                 815     


His Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg Thr Ser 
            820                 825                 830         


Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu 
        835                 840                 845             


Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala Gly Asp 
    850                 855                 860                 


Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser Ser Gln 
865                 870                 875                 880 


Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr Val Val 
                885                 890                 895     


Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
            900                 905                 910         


Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg Glu Met 
        915                 920                 925             


Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn 
    930                 935                 940                 


Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe 
945                 950                 955                 960 


Val Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg 
            980                 985                 990         


Ser Ala Asp Ala Pro Ala Tyr Gln  Gln Gly Gln Asn Gln  Leu Tyr Asn 
        995                 1000                 1005             


Glu Leu  Asn Leu Gly Arg Arg  Glu Glu Tyr Asp Val  Leu Asp Lys 
    1010                 1015                 1020             


Arg Arg  Gly Arg Asp Pro Glu  Met Gly Gly Lys Pro  Arg Arg Lys 
    1025                 1030                 1035             


Asn Pro  Gln Glu Gly Leu Tyr  Asn Glu Leu Gln Lys  Asp Lys Met 
    1040                 1045                 1050             


Ala Glu  Ala Tyr Ser Glu Ile  Gly Met Lys Gly Glu  Arg Arg Arg 
    1055                 1060                 1065             


Gly Lys  Gly His Asp Gly Leu  Tyr Gln Gly Leu Ser  Thr Ala Thr 
    1070                 1075                 1080             


Lys Asp  Thr Tyr Asp Ala Leu  His Met Gln Ala Leu  Pro Pro Arg 
    1085                 1090                 1095             


<210>  43
<211>  1098
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
                565                 570                 575     


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser 
        595                 600                 605             


Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys 
    610                 615                 620                 


Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                645                 650                 655     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            660                 665                 670         


Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        675                 680                 685             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    690                 695                 700                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
705                 710                 715                 720 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                725                 730                 735     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala Gly Arg 
        755                 760                 765             


Thr Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His Tyr Lys 
    770                 775                 780                 


Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly Ala Ala 
785                 790                 795                 800 


Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly 
                805                 810                 815     


His Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg Thr Ser 
            820                 825                 830         


Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu 
        835                 840                 845             


Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala Gly Asp 
    850                 855                 860                 


Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser Ser Gln 
865                 870                 875                 880 


Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr Val Val 
                885                 890                 895     


Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
            900                 905                 910         


Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg Glu Met 
        915                 920                 925             


Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn 
    930                 935                 940                 


Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe 
945                 950                 955                 960 


Val Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg 
            980                 985                 990         


Ser Ala Asp Ala Pro Ala Tyr Gln  Gln Gly Gln Asn Gln  Leu Tyr Asn 
        995                 1000                 1005             


Glu Leu  Asn Leu Gly Arg Arg  Glu Glu Tyr Asp Val  Leu Asp Lys 
    1010                 1015                 1020             


Arg Arg  Gly Arg Asp Pro Glu  Met Gly Gly Lys Pro  Arg Arg Lys 
    1025                 1030                 1035             


Asn Pro  Gln Glu Gly Leu Tyr  Asn Glu Leu Gln Lys  Asp Lys Met 
    1040                 1045                 1050             


Ala Glu  Ala Tyr Ser Glu Ile  Gly Met Lys Gly Glu  Arg Arg Arg 
    1055                 1060                 1065             


Gly Lys  Gly His Asp Gly Leu  Tyr Gln Gly Leu Ser  Thr Ala Thr 
    1070                 1075                 1080             


Lys Asp  Thr Tyr Asp Ala Leu  His Met Gln Ala Leu  Pro Pro Arg 
    1085                 1090                 1095             


<210>  44
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp 
    130                 


<210>  45
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  45

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  46
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  46

Gly Ser Glu Ser Lys Val Asp Gln Ser Val Val Thr Gln Pro Pro Ser 
1               5                   10                  15      


Ala Ser Gly Gly Pro Gly Gln Ser Leu Thr Ile Ser Cys Thr Gly Thr 
            20                  25                  30          


Ser Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln Gln His 
        35                  40                  45              


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Lys Arg Pro 
    50                  55                  60                  


Ser Gly Val Pro His Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
65                  70                  75                  80  


Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Val Thr Val Leu 
        115         


<210>  47
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  47

Gly Ser Glu Ser Lys Val Asp Asp Ile Gln Met Thr Gln Thr Pro Ser 
1               5                   10                  15      


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Ala Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Gly Tyr Thr Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


<210>  48
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  48

Gly Ser Glu Ser Lys Val Asp Ser Ser Glu Leu Thr Gln Asp Pro Ala 
1               5                   10                  15      


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
            20                  25                  30          


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
65                  70                  75                  80  


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
                85                  90                  95      


Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  49
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  49

Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
        115                 120                 125             


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
            180                 185                 190         


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  50
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  50

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gln Val Gln Leu Gln Gln Ser Gly Ala Ser 
    130                 135                 140                 


Met Lys Met Ser Cys Arg Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
145                 150                 155                 160 


Ile His Trp Leu Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Tyr Ile Asp Pro Ala Thr Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Ile Leu Thr Ala Asp Arg Ser Ser Asn Thr Ala Phe Met 
        195                 200                 205             


Tyr Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Glu Ser Pro Arg Leu Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Pro Gln Ala 
                245                 250                 255     


Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
            260                 265             


<210>  51
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  51

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met 
145                 150                 155                 160 


Lys Met Ser Cys Arg Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile 
                165                 170                 175     


His Trp Leu Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asp Pro Ala Thr Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Ile Leu Thr Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr 
    210                 215                 220                 


Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Ser Pro Arg Leu Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys 
            260                 265                 270         


Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
        275                 280             


<210>  52
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Ser Glu Ser Lys Val Asp Gln Ser Val 
    130                 135                 140                 


Val Thr Gln Pro Pro Ser Ala Ser Gly Gly Pro Gly Gln Ser Leu Thr 
145                 150                 155                 160 


Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn His Val 
                165                 170                 175     


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
            180                 185                 190         


Asp Val Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser 
        195                 200                 205             


Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn Asn Leu 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  53
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  53

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Ser Glu Ser Lys Val Asp Gln Ser Val Val 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Ala Ser Gly Gly Pro Gly Gln Ser Leu Thr Ile 
                165                 170                 175     


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn His Val Ser 
            180                 185                 190         


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
        195                 200                 205             


Val Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            260                 265     


<210>  54
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  54

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Ser Glu Ser Lys Val Asp Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Ala Tyr Tyr Cys Gln Gln Gly Tyr Thr Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu 
                245     


<210>  55
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  55

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Ser Glu Ser Lys Val Asp Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Ala Tyr Tyr Cys Gln Gln Gly Tyr Thr Thr Pro Leu Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu 
            260     


<210>  56
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  56

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Ser Glu Ser Lys Val Asp Ser Ser Glu 
    130                 135                 140                 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
145                 150                 155                 160 


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
            180                 185                 190         


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  57
<211>  264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  57

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Ser Glu Ser Lys Val Asp Ser Ser Glu Leu 
145                 150                 155                 160 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile 
                165                 170                 175     


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
        195                 200                 205             


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
    210                 215                 220                 


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Thr Val Leu 
            260                 


<210>  58
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  58

Gly Ser Glu Ser Lys Val Asp Asp Ile Val Met Phe Gln Ser Pro Ala 
1               5                   10                  15      


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
            20                  25                  30          


Ser Gln Ser Val Ser Ser Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln 
        35                  40                  45              


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn 
    50                  55                  60                  


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
65                  70                  75                  80  


Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr 
                85                  90                  95      


Tyr Tyr Cys Gln His Ser Arg Asp Val Pro Leu Thr Phe Gly Ala Gly 
            100                 105                 110         


Thr Lys Leu Glu Ile Lys 
        115             


<210>  59
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  59

Gly Ser Glu Ser Lys Val Asp Asp Ile Gln Met Thr Gln Thr Pro Ser 
1               5                   10                  15      


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
            20                  25                  30          


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
        35                  40                  45              


Gly Thr Val Lys Leu Leu Ile Val Tyr Thr Ser Arg Leu His Ser Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
65                  70                  75                  80  


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
                85                  90                  95      


Gln Gly Asn Thr Leu Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            100                 105                 110         


Leu Lys 
        


<210>  60
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  60

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Ser Glu Ser Lys Val Asp Asp Ile Val 
    130                 135                 140                 


Met Phe Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
145                 150                 155                 160 


Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser Tyr Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
            180                 185                 190         


Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
    210                 215                 220                 


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Asp Val Pro 
225                 230                 235                 240 


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
                245                 250         


<210>  61
<211>  267
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Ser Glu Ser Lys Val Asp Asp Ile Val Met 
145                 150                 155                 160 


Phe Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser Tyr Ser Tyr 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu 
225                 230                 235                 240 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Asp Val Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            260                 265         


<210>  62
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mus musculus

<400>  62

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Ser Glu Ser Lys Val Asp Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Val Tyr Thr 
            180                 185                 190         


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
    210                 215                 220                 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys 
                245             


<210>  63
<211>  263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  63

Gln Val Gln Leu Gln Gln Ser Gly Ala Ser Met Lys Met Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Leu Lys Gln 
            20                  25                  30          


Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro Ala Thr 
        35                  40                  45              


Ala Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr 
    50                  55                  60                  


Ala Asp Arg Ser Ser Asn Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr 
65                  70                  75                  80  


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro Arg Leu 
                85                  90                  95      


Arg Arg Gly Ile Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Pro Gln Ala Lys Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Glu Ser Lys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Ser Glu Ser Lys Val Asp Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Val Tyr Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro Thr Phe Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Glu Leu Lys 
            260             


<210>  64
<211>  3192
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  64
actagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccctggatc catggcctta ccagtgaccg ccttgctcct     1740

gccgctggcc ttgctgctcc acgccgccag gccggaacag aaactcatca gtgaggaaga     1800

tttgcagacg actccaggag agagatcatc actccctgcc ttttaccctg gcacttcagg     1860

ctcttgttcc ggatgtgggt ccctctctct gccgacaaca acccctgccc ccagacctcc     1920

taccccagcc cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc     1980

tgctgctggc ggagccgtgc acaccagagg actggatttc gcctgcgacc taggttctgg     2040

gtgctggtgg tcgtgggcgg agtgctggcc tgttacagcc tgctcgtgac cgtggccttc     2100

atcatctttt gggtgcggag caagagaagc agactgctgc acagcgacta catgaacatg     2160

acccccagac ggcctggccc caccagaaag cactaccagc cttacgcccc tcccagagac     2220

ttcgccgcct acagatctcc cgggggaggc ggaggatctg gcggaggtgg aagtggcgga     2280

ggcggatcta tgagccagag caacagagaa ctggtggtgg acttcctgag ctacaagctg     2340

agccagaagg gctacagctg gtcccagttc agcgacgtgg aagagaacag aacagaggcc     2400

cctgagggca cagagtctga ggctgtgaaa caggccctga gagaagccgg cgacgagttc     2460

gagctgagat acagaagggc cttcagcgac ctgaccagcc agctgcacat cacacctggc     2520

acagcctacc agagcttcga gcaggtcgtg aacgagctgt tcagagatgg cgtgaactgg     2580

ggcagaatcg tggccttctt cagctttggc ggagccctgt gtgtggaaag cgtggacaaa     2640

gaaatgcagg tcctggtgtc cagaatcgcc gcctggatgg ccacctacct gaacgatcat     2700

ctggaaccct ggattcaaga gaacggcggc tgggacacct tcgtggaact gtacggaaac     2760

aacgccgctg ccgagagcag aaagggccaa gaacgagaag atggaggcgg aggatctggc     2820

ggaggtggaa gtggcggagg cggatctatg catagagtga agttcagcag gagcgcagac     2880

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     2940

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     3000

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     3060

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     3120

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     3180

ccccctcgct aa                                                         3192


<210>  65
<211>  1059
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    930                 935                 940                 


Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
945                 950                 955                 960 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                965                 970                 975     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            980                 985                 990         


Gly Gly Lys Pro Arg Arg Lys Asn  Pro Gln Glu Gly Leu  Tyr Asn Glu 
        995                 1000                 1005             


Leu Gln  Lys Asp Lys Met Ala  Glu Ala Tyr Ser Glu  Ile Gly Met 
    1010                 1015                 1020             


Lys Gly  Glu Arg Arg Arg Gly  Lys Gly His Asp Gly  Leu Tyr Gln 
    1025                 1030                 1035             


Gly Leu  Ser Thr Ala Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met 
    1040                 1045                 1050             


Gln Ala  Leu Pro Pro Arg 
    1055                 


<210>  66
<211>  3198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  66
actagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccctggatc catggcctta ccagtgaccg ccttgctcct     1740

gccgctggcc ttgctgctcc acgccgccag gccggaacag aaactcatca gtgaggaaga     1800

tttgcagacg actccaggag agagatcatc actccctgcc ttttaccctg gcacttcagg     1860

ctcttgttcc ggatgtgggt ccctctctct gccgacaaca acccctgccc ccagacctcc     1920

taccccagcc cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc     1980

tgctgctggc ggagccgtgc acaccagagg actggatttc gcctgcgacc taggttctgg     2040

gtgctggtgg tcgtgggcgg agtgctggcc tgttacagcc tgctcgtgac cgtggccttc     2100

atcatctttt gggtgcggag caagagaagc agactgctgc acagcgacta catgaacatg     2160

acccccagac ggcctggccc caccagaaag cactaccagc cttacgcccc tcccagagac     2220

ttcgccgcct acagatctcc cgggggaggc ggaggatctg gcggaggtgg aagtggcgga     2280

ggcggatcta tgagccagag caacagagaa ctggtggtgg acttcctgag ctacaagctg     2340

agccagaagg gctacagctg gtcccagttc agcgacgtgg aagagaacag aacagaggcc     2400

cctgagggca cagagtctga ggctgtgaaa caggccctga gagaagccgg cgacgacttc     2460

gagctgagat acagaagggc cttcagcgac ctgaccagcc agctgcacat cacacctggc     2520

acagcctacc agagcttcga gcaggtcgtg aacgagctgt tcagagatgg cgtgaactgg     2580

ggcagaatcg tggccttctt cagctttggc ggagccctgt gtgtggaaag cgtggacaaa     2640

gaaatgcagg tcctggtgtc cagaatcgcc gcctggatgg ccacctacct gaacgatcat     2700

ctggaaccct ggattcaaga gaacggcggc tgggacacct tcgtggaact gtacggaaac     2760

aacgccgctg ccgagagcag aaagggccaa gaacgagaag atgaagatgg aggcggagga     2820

tctggcggag gtggaagtgg cggaggcgga tctatgcata gagtgaagtt cagcaggagc     2880

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     2940

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     3000

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     3060

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     3120

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     3180

gccctgcccc ctcgctaa                                                   3198


<210>  67
<211>  1061
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    930                 935                 940                 


Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
945                 950                 955                 960 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                965                 970                 975     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            980                 985                 990         


Glu Met Gly Gly Lys Pro Arg Arg  Lys Asn Pro Gln Glu  Gly Leu Tyr 
        995                 1000                 1005             


Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu Ala Tyr  Ser Glu Ile 
    1010                 1015                 1020             


Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys Gly His  Asp Gly Leu 
    1025                 1030                 1035             


Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp Thr Tyr  Asp Ala Leu 
    1040                 1045                 1050             


His Met  Gln Ala Leu Pro Pro  Arg 
    1055                 1060     


<210>  68
<211>  3306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  68
actagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccctggatc catggcctta ccagtgaccg ccttgctcct     1740

gccgctggcc ttgctgctcc acgccgccag gccggaacag aaactcatca gtgaggaaga     1800

tttgcagacg actccaggag agagatcatc actccctgcc ttttaccctg gcacttcagg     1860

ctcttgttcc ggatgtgggt ccctctctct gccgacaaca acccctgccc ccagacctcc     1920

taccccagcc cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc     1980

tgctgctggc ggagccgtgc acaccagagg actggatttc gcctgcgacc taggttctgg     2040

gtgctggtgg tcgtgggcgg agtgctggcc tgttacagcc tgctcgtgac cgtggccttc     2100

atcatctttt gggtgcggag caagagaagc agactgctgc acagcgacta catgaacatg     2160

acccccagac ggcctggccc caccagaaag cactaccagc cttacgcccc tcccagagac     2220

ttcgccgcct acagatctcc cgggggaggc ggaggatctg gcggaggtgg aagtggcgga     2280

ggcggatcta tggcccacgc cggcaggacc ggctacgaca acagggagat cgtgatgaag     2340

tacatccact acaagctgag ccagaggggc tacgagtggg acgccggcga cgtgggcgcc     2400

gccccccccg gcgccgcccc cgcccccggc atcttcagca gccagcccgg ccacaccccc     2460

caccccgccg ccagcaggga ccccgtggcc aggaccagcc ccctgcagac ccccgccgcc     2520

cccggcgccg ccgccggccc cgccctgagc cccgtgcccc ccgtggtgca cctgaccctg     2580

aggcaggccg gcgacgactt cagcaggagg tacaggaggg acttcgccga gatgagcagc     2640

cagctgcacc tgaccccctt caccgccagg ggcaggttcg ccaccgtggt ggaggagctg     2700

ttcagggacg gcgtgaactg gggcaggatc gtggccttct tcgagttcgg cggcgtgatg     2760

tgcgtggaga gcgtgaacag ggagatgagc cccctggtgg acaacatcgc cctgtggatg     2820

accgagtacc tgaacaggca cctgcacacc tggatccagg acaacggcgg ctgggacgcc     2880

ttcgtggagc tgtacggccc cagcatgagg gaagatggag gcggaggatc tggcggaggt     2940

ggaagtggcg gaggcggatc tatgcataga gtgaagttca gcaggagcgc agacgccccc     3000

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     3060

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     3120

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     3180

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     3240

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     3300

cgctaa                                                                3306


<210>  69
<211>  1097
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala Gly Arg Thr 
        755                 760                 765             


Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His Tyr Lys Leu 
    770                 775                 780                 


Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly Ala Ala Pro 
785                 790                 795                 800 


Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly His 
                805                 810                 815     


Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg Thr Ser Pro 
            820                 825                 830         


Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser 
        835                 840                 845             


Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala Gly Asp Asp 
    850                 855                 860                 


Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser Ser Gln Leu 
865                 870                 875                 880 


His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr Val Val Glu 
                885                 890                 895     


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
            900                 905                 910         


Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg Glu Met Ser 
        915                 920                 925             


Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg 
    930                 935                 940                 


His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe Val 
945                 950                 955                 960 


Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser 
            980                 985                 990         


Ala Asp Ala Pro Ala Tyr Gln Gln  Gly Gln Asn Gln Leu  Tyr Asn Glu 
        995                 1000                 1005             


Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp Val Leu  Asp Lys Arg 
    1010                 1015                 1020             


Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys Pro Arg  Arg Lys Asn 
    1025                 1030                 1035             


Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala 
    1040                 1045                 1050             


Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly 
    1055                 1060                 1065             


Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys 
    1070                 1075                 1080             


Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1085                 1090                 1095         


<210>  70
<211>  3193
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  70
actagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcca aagatgggaa ctcgccctgg     1200

gcagattcct ggaatacctg agctgggtgt ccacactgag cgaacaggtg caagaggaac     1260

tgctgagcag ccaagtgacc caagagctga gagccctgat ggacgagaca atgaaggaac     1320

tgaaggccta caagagcgag ctggaagaac agctgacccc tgtggccgag gaaaccagag     1380

ccagactgag caaagaactg caggccgctc aggccagact gggagccgat atggaagatg     1440

ttcggggcag actggtgcag tacagaggcg aagttcaggc catgctgggc cagtctaccg     1500

aggaactgag agtgcggctg gcctctcatc tgattgccct gcaggcaaga ctgatcggcg     1560

acgcattcga cctgcagaaa agactggccg tgtaccaggc tggcgctgct gaacggaagc     1620

ggcgcagcgg cagcgggcgc agcggcagcg gcgagggcag aggaagtctt ctaacatgcg     1680

gtgacgtgga ggagaatccc ggccctggat ccatggcctt accagtgacc gccttgctcc     1740

tgccgctggc cttgctgctc cacgccgcca ggccggaaca gaaactcatc agtgaggaag     1800

atttgcagac gactccagga gagagatcat cactccctgc cttttaccct ggcacttcag     1860

gctcttgttc cggatgtggg tccctctctc tgccgacaac aacccctgcc cccagacctc     1920

ctaccccagc ccctacaatt gccagccagc ctctgagcct gaggcccgag gcttgtagac     1980

ctgctgctgg cggagccgtg cacaccagag gactggattt cgcctgcgac ctaggttctg     2040

ggtgctggtg gtcgtgggcg gagtgctggc ctgttacagc ctgctcgtga ccgtggcctt     2100

catcatcttt tgggtgcgga gcaagagaag cagactgctg cacagcgact acatgaacat     2160

gacccccaga cggcctggcc ccaccagaaa gcactaccag ccttacgccc ctcccagaga     2220

cttcgccgcc tacagatctc ccgggggagg cggaggatct ggcggaggtg gaagtggcgg     2280

aggcggatct atgagccaga gcaacagaga actggtggtg gacttcctga gctacaagct     2340

gagccagaag ggctacagct ggtcccagtt cagcgacgtg gaagagaaca gaacagaggc     2400

ccctgagggc acagagtctg aggctgtgaa acaggccctg agagaagccg gcgacgagtt     2460

cgagctgaga tacagaaggg ccttcagcga cctgaccagc cagctgcaca tcacacctgg     2520

cacagcctac cagagcttcg agcaggtcgt gaacgagctg ttcagagatg gcgtgaactg     2580

gggcagaatc gtggccttct tcagctttgg cggagccctg tgtgtggaaa gcgtggacaa     2640

agaaatgcag gtcctggtgt ccagaatcgc cgcctggatg gccacctacc tgaacgatca     2700

tctggaaccc tggattcaag agaacggcgg ctgggacacc ttcgtggaac tgtacggaaa     2760

caacgccgct gccgagagca gaaagggcca agaacgagaa gatggaggcg gaggatctgg     2820

cggaggtgga agtggcggag gcggatctat gcatagagtg aagttcagca ggagcgcaga     2880

cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag     2940

agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc     3000

gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga     3060

ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct     3120

ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct     3180

gccccctcgc taa                                                        3193


<210>  71
<211>  1059
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    930                 935                 940                 


Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
945                 950                 955                 960 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                965                 970                 975     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            980                 985                 990         


Gly Gly Lys Pro Arg Arg Lys Asn  Pro Gln Glu Gly Leu  Tyr Asn Glu 
        995                 1000                 1005             


Leu Gln  Lys Asp Lys Met Ala  Glu Ala Tyr Ser Glu  Ile Gly Met 
    1010                 1015                 1020             


Lys Gly  Glu Arg Arg Arg Gly  Lys Gly His Asp Gly  Leu Tyr Gln 
    1025                 1030                 1035             


Gly Leu  Ser Thr Ala Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met 
    1040                 1045                 1050             


Gln Ala  Leu Pro Pro Arg 
    1055                 


<210>  72
<211>  3191
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  72
actagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcgc     1560

agcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctctga acggaagcgg     1620

cgcagcggca gcgggcgcag cggcagcggc gagggcagag gaagtcttct aacatgcggt     1680

gacgtggagg agaatcccgg ccctggatcc atggccttac cagtgaccgc cttgctcctg     1740

ccgctggcct tgctgctcca cgccgccagg ccggaacaga aactcatcag tgaggaagat     1800

ttgcagacga ctccaggaga gagatcatca ctccctgcct tttaccctgg cacttcaggc     1860

tcttgttccg gatgtgggtc cctctctctg ccgacaacaa cccctgcccc cagacctcct     1920

accccagccc ctacaattgc cagccagcct ctgagcctga ggcccgaggc ttgtagacct     1980

gctgctggcg gagccgtgca caccagagga ctggatttcg cctgcgacct aggttctggg     2040

tgctggtggt cgtgggcgga gtgctggcct gttacagcct gctcgtgacc gtggccttca     2100

tcatcttttg ggtgcggagc aagagaagca gactgctgca cagcgactac atgaacatga     2160

cccccagacg gcctggcccc accagaaagc actaccagcc ttacgcccct cccagagact     2220

tcgccgccta cagatctccc gggggaggcg gaggatctgg cggaggtgga agtggcggag     2280

gcggatctat gagccagagc aacagagaac tggtggtgga cttcctgagc tacaagctga     2340

gccagaaggg ctacagctgg tcccagttca gcgacgtgga agagaacaga acagaggccc     2400

ctgagggcac agagtctgag gctgtgaaac aggccctgag agaagccggc gacgagttcg     2460

agctgagata cagaagggcc ttcagcgacc tgaccagcca gctgcacatc acacctggca     2520

cagcctacca gagcttcgag caggtcgtga acgagctgtt cagagatggc gtgaactggg     2580

gcagaatcgt ggccttcttc agctttggcg gagccctgtg tgtggaaagc gtggacaaag     2640

aaatgcaggt cctggtgtcc agaatcgccg cctggatggc cacctacctg aacgatcatc     2700

tggaaccctg gattcaagag aacggcggct gggacacctt cgtggaactg tacggaaaca     2760

acgccgctgc cgagagcaga aagggccaag aacgagaaga tggaggcgga ggatctggcg     2820

gaggtggaag tggcggaggc ggatctatgc atagagtgaa gttcagcagg agcgcagacg     2880

cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag     2940

aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga     3000

gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg     3060

cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt     3120

accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc     3180

cccctcgcta a                                                          3191


<210>  73
<211>  1059
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu 
                565                 570                 575     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser 
        595                 600                 605             


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
    610                 615                 620                 


Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                645                 650                 655     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            660                 665                 670         


Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        675                 680                 685             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    690                 695                 700                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
705                 710                 715                 720 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                725                 730                 735     


Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu 
        755                 760                 765             


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
    770                 775                 780                 


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
785                 790                 795                 800 


Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp 
                805                 810                 815     


Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln 
            820                 825                 830         


Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val 
        835                 840                 845             


Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe 
    850                 855                 860                 


Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met 
865                 870                 875                 880 


Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn 
                885                 890                 895     


Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe 
            900                 905                 910         


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
        915                 920                 925             


Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    930                 935                 940                 


Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
945                 950                 955                 960 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                965                 970                 975     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            980                 985                 990         


Gly Gly Lys Pro Arg Arg Lys Asn  Pro Gln Glu Gly Leu  Tyr Asn Glu 
        995                 1000                 1005             


Leu Gln  Lys Asp Lys Met Ala  Glu Ala Tyr Ser Glu  Ile Gly Met 
    1010                 1015                 1020             


Lys Gly  Glu Arg Arg Arg Gly  Lys Gly His Asp Gly  Leu Tyr Gln 
    1025                 1030                 1035             


Gly Leu  Ser Thr Ala Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met 
    1040                 1045                 1050             


Gln Ala  Leu Pro Pro Arg 
    1055                 


<210>  74
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  74

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  75
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  75

Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr 
1               5                   10                  15      


Val Ser Pro 
            


<210>  76
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  77
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  78
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  78

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr 
        195                 200                 205             


Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu 
    210                 215                 220                 


Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys 
225                 230                 235                 240 


Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg 
                245                 250                 255     


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
            260                 265                 270         


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
        275                 280                 285             


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
    290                 295                 300                 


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
305                 310                 315                 320 


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
                325                 330                 335     


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala 
            340                 345                 350         


Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  79
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  79

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  80
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  80

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  81
<211>  531
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  81

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu 
        195                 200                 205             


Ile Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu 
    210                 215                 220                 


Trp Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala 
225                 230                 235                 240 


Pro Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala 
                245                 250                 255     


Ser Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala 
            260                 265                 270         


Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val 
        275                 280                 285             


His Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg 
    290                 295                 300                 


Arg Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr 
305                 310                 315                 320 


Ala Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly 
                325                 330                 335     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met 
            340                 345                 350         


Cys Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile 
        355                 360                 365             


Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile 
    370                 375                 380                 


Gln Asp Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser 
385                 390                 395                 400 


Met Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             


Pro Pro Arg 
    530     


<210>  82
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  83
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  83

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  84
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  84

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  85
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  85

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  86
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  86

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  87
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  87

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  88
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  89
<211>  531
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  89

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu 
        195                 200                 205             


Ile Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu 
    210                 215                 220                 


Trp Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala 
225                 230                 235                 240 


Pro Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala 
                245                 250                 255     


Ser Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala 
            260                 265                 270         


Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val 
        275                 280                 285             


His Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg 
    290                 295                 300                 


Arg Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr 
305                 310                 315                 320 


Ala Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly 
                325                 330                 335     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met 
            340                 345                 350         


Cys Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile 
        355                 360                 365             


Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile 
    370                 375                 380                 


Gln Asp Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser 
385                 390                 395                 400 


Met Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             


Pro Pro Arg 
    530     


<210>  90
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  90

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  91
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  91

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  92
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg 
    530                 535                 540                 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
545                 550                 555                 560 


Glu Glu Asn Pro Gly Pro 
                565     


<210>  93
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  93

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  94
<211>  1698
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  94
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc agtgaggata      120

tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt gaagcagagc      180

catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg taccacctac      240

aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag tacagcctac      300

atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc agctggttgg      360

aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg aggtggatca      420

ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc tcacaaattc      480

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt      540

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg      600

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac      660

ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt ctgtcagcaa      720

tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa acgggctagc      780

acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg      840

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      900

gatttcgcct gcgacttctg ggtgctggtg gtcgtgggcg gagtgctggc ctgttacagc      960

ctgctcgtga ccgtggcctt catcatcttt tgggtgcgga gcaagagaag cagactgctg     1020

cacagcgact acatgaacat gacccccaga cggcctggcc ccaccagaaa gcactaccag     1080

ccttacgccc ctcccagaga cttcgccgcc tacagatctc atatgggagg cggaggatct     1140

ggcggaggtg gaagtggcgg aggcggatct caaagatggg aactcgccct gggcagattc     1200

ctggaatacc tgagctgggt gtccacactg agcgaacagg tgcaagagga actgctgagc     1260

agccaagtga cccaagagct gagagccctg atggacgaga caatgaagga actgaaggcc     1320

tacaagagcg agctggaaga acagctgacc cctgtggccg aggaaaccag agccagactg     1380

agcaaagaac tgcaggccgc tcaggccaga ctgggagccg atatggaaga tgttcggggc     1440

agactggtgc agtacagagg cgaagttcag gccatgctgg gccagtctac cgaggaactg     1500

agagtgcggc tggcctctca tctgattgcc ctgcagctga gactgatcgg cgacgcattc     1560

gacctgcaga aaagactggc cgtgtaccag gctggcgctg ctgaacggaa gcggcgcagc     1620

ggcagcgggc gcagcggcag cggcgagggc agaggaagtc ttctaacatg cggtgacgtg     1680

gaggagaatc ccggccct                                                   1698


<210>  95
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  95
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  96
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  96
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  97
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  97
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  98
<211>  1706
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  98
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcca aagatgggaa ctcgccctgg     1200

gcagattcct ggaatacctg agctgggtgt ccacactgag cgaacaggtg caagaggaac     1260

tgctgagcag ccaagtgacc caagagctga gagccctgat ggacgagaca atgaaggaac     1320

tgaaggccta caagagcgag ctggaagaac agctgacccc tgtggccgag gaaaccagag     1380

ccagactgag caaagaactg caggccgctc aggccagact gggagccgat atggaagatg     1440

ttcggggcag actggtgcag tacagaggcg aagttcaggc catgctgggc cagtctaccg     1500

aggaactgag agtgcggctg gcctctcatc tgattgccct gcaggcaaga ctgatcggcg     1560

acgcattcga cctgcagaaa agactggccg tgtaccaggc tggcgctgct gaacggaagc     1620

ggcgcagcgg cagcgggcgc agcggcagcg gcgagggcag aggaagtctt ctaacatgcg     1680

gtgacgtgga ggagaatccc ggccct                                          1706


<210>  99
<211>  1704
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  99
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcgc     1560

agcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctctga acggaagcgg     1620

cgcagcggca gcgggcgcag cggcagcggc gagggcagag gaagtcttct aacatgcggt     1680

gacgtggagg agaatcccgg ccct                                            1704


<210>  100
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  100
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgaccctagg ttctgggtgc tggtggtcgt gggcggagtg      360

ctggcctgtt acagcctgct cgtgaccgtg gccttcatca tcttttgggt gcggagcaag      420

agaagcagac tgctgcacag cgactacatg aacatgaccc ccagacggcc tggccccacc      480

agaaagcact accagcctta cgcccctccc agagacttcg ccgcctacag atctcccggg      540

ggaggcggag gatctggcgg aggtggaagt ggcggaggcg gatctatgag ccagagcaac      600

agagaactgg tggtggactt cctgagctac aagctgagcc agaagggcta cagctggtcc      660

cagttcagcg acgtggaaga gaacagaaca gaggcccctg agggcacaga gtctgaggct      720

gtgaaacagg ccctgagaga agccggcgac gagttcgagc tgagatacag aagggccttc      780

agcgacctga ccagccagct gcacatcaca cctggcacag cctaccagag cttcgagcag      840

gtcgtgaacg agctgttcag agatggcgtg aactggggca gaatcgtggc cttcttcagc      900

tttggcggag ccctgtgtgt ggaaagcgtg gacaaagaaa tgcaggtcct ggtgtccaga      960

atcgccgcct ggatggccac ctacctgaac gatcatctgg aaccctggat tcaagagaac     1020

ggcggctggg acaccttcgt ggaactgtac ggaaacaacg ccgctgccga gagcagaaag     1080

ggccaagaac gagaagatgg cggcggtggt tctggtggcg gcggtagtgg tggcggtgga     1140

tcaatgcata gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1200

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1260

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1320

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1380

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1440

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  1488


<210>  101
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  101
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  102
<211>  1493
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  102
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg acttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgaa gatggaggcg gaggatctgg cggaggtgga agtggcggag     1140

gcggatctat gcatagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1200

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1260

acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa            1493


<210>  103
<211>  1601
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  103
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatggcc cacgccggca      600

ggaccggcta cgacaacagg gagatcgtga tgaagtacat ccactacaag ctgagccaga      660

ggggctacga gtgggacgcc ggcgacgtgg gcgccgcccc ccccggcgcc gcccccgccc      720

ccggcatctt cagcagccag cccggccaca ccccccaccc cgccgccagc agggaccccg      780

tggccaggac cagccccctg cagacccccg ccgcccccgg cgccgccgcc ggccccgccc      840

tgagccccgt gccccccgtg gtgcacctga ccctgaggca ggccggcgac gacttcagca      900

ggaggtacag gagggacttc gccgagatga gcagccagct gcacctgacc cccttcaccg      960

ccaggggcag gttcgccacc gtggtggagg agctgttcag ggacggcgtg aactggggca     1020

ggatcgtggc cttcttcgag ttcggcggcg tgatgtgcgt ggagagcgtg aacagggaga     1080

tgagccccct ggtggacaac atcgccctgt ggatgaccga gtacctgaac aggcacctgc     1140

acacctggat ccaggacaac ggcggctggg acgccttcgt ggagctgtac ggccccagca     1200

tgagggaaga tggaggcgga ggatctggcg gaggtggaag tggcggaggc ggatctatgc     1260

atagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc cagaaccagc     1320

tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac aagagacgtg     1380

gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca     1440

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1500

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1560

cctacgacgc ccttcacatg caggccctgc cccctcgcta a                         1601


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  105
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  105

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  106
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  106

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  107
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  108
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  108

Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
        115                 120                 125             


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
            180                 185                 190         


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  109
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  109

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


<210>  110
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  110

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


<210>  111
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  111

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


<210>  112
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  112

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


<210>  113
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  113

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser 
                165                 170                 175     


Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val 
            180                 185                 190         


Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val 
        195                 200                 205             


Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg 
    210                 215                 220                 


Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr 
225                 230                 235                 240 


Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly 
                245                 250                 255     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu 
            260                 265                 270         


Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile 
        275                 280                 285             


Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
    290                 295                 300                 


Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn 
305                 310                 315                 320 


Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  114
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  114

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser 
                165                 170                 175     


Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val 
            180                 185                 190         


Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val 
        195                 200                 205             


Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg 
    210                 215                 220                 


Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr 
225                 230                 235                 240 


Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly 
                245                 250                 255     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu 
            260                 265                 270         


Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile 
        275                 280                 285             


Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
    290                 295                 300                 


Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn 
305                 310                 315                 320 


Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  115
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  115

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser 
                165                 170                 175     


Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val 
            180                 185                 190         


Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val 
        195                 200                 205             


Lys Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg 
    210                 215                 220                 


Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr 
225                 230                 235                 240 


Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly 
                245                 250                 255     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu 
            260                 265                 270         


Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile 
        275                 280                 285             


Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
    290                 295                 300                 


Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn 
305                 310                 315                 320 


Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  116
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  116

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser 
                165                 170                 175     


Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val 
            180                 185                 190         


Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val 
        195                 200                 205             


Lys Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg 
    210                 215                 220                 


Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr 
225                 230                 235                 240 


Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly 
                245                 250                 255     


Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu 
            260                 265                 270         


Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile 
        275                 280                 285             


Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
    290                 295                 300                 


Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn 
305                 310                 315                 320 


Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  117
<211>  498
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  117

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile 
                165                 170                 175     


Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp 
            180                 185                 190         


Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro 
        195                 200                 205             


Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser 
    210                 215                 220                 


Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro 
225                 230                 235                 240 


Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His 
                245                 250                 255     


Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg 
            260                 265                 270         


Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala 
        275                 280                 285             


Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val 
    290                 295                 300                 


Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys 
305                 310                 315                 320 


Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala 
                325                 330                 335     


Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln 
            340                 345                 350         


Asp Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met 
        355                 360                 365             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  118
<211>  1698
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  118
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc agtgaggata      120

tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt gaagcagagc      180

catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg taccacctac      240

aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag tacagcctac      300

atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc agctggttgg      360

aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg aggtggatca      420

ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc tcacaaattc      480

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt      540

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg      600

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac      660

ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt ctgtcagcaa      720

tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa acgggctagc      780

acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg      840

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      900

gatttcgcct gcgacttctg ggtgctggtg gtcgtgggcg gagtgctggc ctgttacagc      960

ctgctcgtga ccgtggcctt catcatcttt tgggtgcgga gcaagagaag cagactgctg     1020

cacagcgact acatgaacat gacccccaga cggcctggcc ccaccagaaa gcactaccag     1080

ccttacgccc ctcccagaga cttcgccgcc tacagatctc atatgggagg cggaggatct     1140

ggcggaggtg gaagtggcgg aggcggatct caaagatggg aactcgccct gggcagattc     1200

ctggaatacc tgagctgggt gtccacactg agcgaacagg tgcaagagga actgctgagc     1260

agccaagtga cccaagagct gagagccctg atggacgaga caatgaagga actgaaggcc     1320

tacaagagcg agctggaaga acagctgacc cctgtggccg aggaaaccag agccagactg     1380

agcaaagaac tgcaggccgc tcaggccaga ctgggagccg atatggaaga tgttcggggc     1440

agactggtgc agtacagagg cgaagttcag gccatgctgg gccagtctac cgaggaactg     1500

agagtgcggc tggcctctca tctgattgcc ctgcagctga gactgatcgg cgacgcattc     1560

gacctgcaga aaagactggc cgtgtaccag gctggcgctg ctgaacggaa gcggcgcagc     1620

ggcagcgggc gcagcggcag cggcgagggc agaggaagtc ttctaacatg cggtgacgtg     1680

gaggagaatc ccggccct                                                   1698


<210>  119
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  119
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  120
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  120
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  121
<211>  1705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  121
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcga     1560

cgcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctgctg aacggaagcg     1620

gcgcagcggc agcgggcgca gcggcagcgg cgagggcaga ggaagtcttc taacatgcgg     1680

tgacgtggag gagaatcccg gccct                                           1705


<210>  122
<211>  1706
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  122
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcca aagatgggaa ctcgccctgg     1200

gcagattcct ggaatacctg agctgggtgt ccacactgag cgaacaggtg caagaggaac     1260

tgctgagcag ccaagtgacc caagagctga gagccctgat ggacgagaca atgaaggaac     1320

tgaaggccta caagagcgag ctggaagaac agctgacccc tgtggccgag gaaaccagag     1380

ccagactgag caaagaactg caggccgctc aggccagact gggagccgat atggaagatg     1440

ttcggggcag actggtgcag tacagaggcg aagttcaggc catgctgggc cagtctaccg     1500

aggaactgag agtgcggctg gcctctcatc tgattgccct gcaggcaaga ctgatcggcg     1560

acgcattcga cctgcagaaa agactggccg tgtaccaggc tggcgctgct gaacggaagc     1620

ggcgcagcgg cagcgggcgc agcggcagcg gcgagggcag aggaagtctt ctaacatgcg     1680

gtgacgtgga ggagaatccc ggccct                                          1706


<210>  123
<211>  1704
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  123
tctagaaatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gtgcagctgc agcagtcagg acctgaactg gtgaagcctg ggacttcagt      120

gaggatatcc tgcaagactt ctggatacac attcactgaa tataccatac actgggtgaa      180

gcagagccat ggaaagagcc ttgagtggat tggaaacatc aatcctaaca atggtggtac      240

cacctacaat cagaagttcg aggacaaggc cacattgact gtagacaagt cctccagtac      300

agcctacatg gagctccgca gcctaacatc tgaggattct gcagtctatt attgtgcagc      360

tggttggaac tttgactact ggggccaagg gaccacggtc accgtctcct caggtggagg      420

tggatcaggt ggaggtggat ctggtggagg tggatctgac attgtgatga cccagtctca      480

caaattcatg tccacatcag taggagacag ggtcagcatc atctgtaagg ccagtcaaga      540

tgtgggtact gctgtagact ggtatcaaca gaaaccagga caatctccta aactactgat      600

ttattgggca tccactcggc acactggagt ccctgatcgc ttcacaggca gtggatctgg      660

gacagacttc actctcacca ttactaatgt tcagtctgaa gacttggcag attatttctg      720

tcagcaatat aacagctatc ccctcacgtt cggtgctggg accatgctgg acctgaaacg      780

ggctagcaca acaacccctg cccccagacc tcctacccca gcccctacaa ttgccagcca      840

gcctctgagc ctgaggcccg aggcttgtag acctgctgct ggcggagccg tgcacaccag      900

aggactggat ttcgcctgcg acttctgggt gctggtggtc gtgggcggag tgctggcctg      960

ttacagcctg ctcgtgaccg tggccttcat catcttttgg gtgcggagca agagaagcag     1020

actgctgcac agcgactaca tgaacatgac ccccagacgg cctggcccca ccagaaagca     1080

ctaccagcct tacgcccctc ccagagactt cgccgcctac agatctcata tgggaggcgg     1140

aggatctggc ggaggtggaa gtggcggagg cggatctcaa agatgggaac tcgccctggg     1200

cagattcctg gaatacctga gctgggtgtc cacactgagc gaacaggtgc aagaggaact     1260

gctgagcagc caagtgaccc aagagctgag agccctgatg gacgagacaa tgaaggaact     1320

gaaggcctac aagagcgagc tggaagaaca gctgacccct gtggccgagg aaaccagagc     1380

cagactgagc aaagaactgc aggccgctca ggccagactg ggagccgata tggaagatgt     1440

tcggggcaga ctggtgcagt acagaggcga agttcaggcc atgctgggcc agtctaccga     1500

ggaactgaga gtgcggctgg cctctcatct gattgccctg cagctgagac tgatcggcgc     1560

agcattcgac ctgcagaaaa gactggccgt gtaccaggct ggcgctctga acggaagcgg     1620

cgcagcggca gcgggcgcag cggcagcggc gagggcagag gaagtcttct aacatgcggt     1680

gacgtggagg agaatcccgg ccct                                            1704


<210>  124
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  124
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgaccctagg ttctgggtgc tggtggtcgt gggcggagtg      360

ctggcctgtt acagcctgct cgtgaccgtg gccttcatca tcttttgggt gcggagcaag      420

agaagcagac tgctgcacag cgactacatg aacatgaccc ccagacggcc tggccccacc      480

agaaagcact accagcctta cgcccctccc agagacttcg ccgcctacag atctcccggg      540

ggaggcggag gatctggcgg aggtggaagt ggcggaggcg gatctatgag ccagagcaac      600

agagaactgg tggtggactt cctgagctac aagctgagcc agaagggcta cagctggtcc      660

cagttcagcg acgtggaaga gaacagaaca gaggcccctg agggcacaga gtctgaggct      720

gtgaaacagg ccctgagaga agccggcgac gagttcgagc tgagatacag aagggccttc      780

agcgacctga ccagccagct gcacatcaca cctggcacag cctaccagag cttcgagcag      840

gtcgtgaacg agctgttcag agatggcgtg aactggggca gaatcgtggc cttcttcagc      900

tttggcggag ccctgtgtgt ggaaagcgtg gacaaagaaa tgcaggtcct ggtgtccaga      960

atcgccgcct ggatggccac ctacctgaac gatcatctgg aaccctggat tcaagagaac     1020

ggcggctggg acaccttcgt ggaactgtac ggaaacaacg ccgctgccga gagcagaaag     1080

ggccaagaac gagaagatgg cggcggtggt tctggtggcg gcggtagtgg tggcggtgga     1140

tcaatgcata gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1200

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1260

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1320

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1380

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1440

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  1488


<210>  125
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  125
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  126
<211>  1493
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  126
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg acttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgaa gatggaggcg gaggatctgg cggaggtgga agtggcggag     1140

gcggatctat gcatagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1200

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1260

acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa            1493


<210>  127
<211>  1601
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  127
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatggcc cacgccggca      600

ggaccggcta cgacaacagg gagatcgtga tgaagtacat ccactacaag ctgagccaga      660

ggggctacga gtgggacgcc ggcgacgtgg gcgccgcccc ccccggcgcc gcccccgccc      720

ccggcatctt cagcagccag cccggccaca ccccccaccc cgccgccagc agggaccccg      780

tggccaggac cagccccctg cagacccccg ccgcccccgg cgccgccgcc ggccccgccc      840

tgagccccgt gccccccgtg gtgcacctga ccctgaggca ggccggcgac gacttcagca      900

ggaggtacag gagggacttc gccgagatga gcagccagct gcacctgacc cccttcaccg      960

ccaggggcag gttcgccacc gtggtggagg agctgttcag ggacggcgtg aactggggca     1020

ggatcgtggc cttcttcgag ttcggcggcg tgatgtgcgt ggagagcgtg aacagggaga     1080

tgagccccct ggtggacaac atcgccctgt ggatgaccga gtacctgaac aggcacctgc     1140

acacctggat ccaggacaac ggcggctggg acgccttcgt ggagctgtac ggccccagca     1200

tgagggaaga tggaggcgga ggatctggcg gaggtggaag tggcggaggc ggatctatgc     1260

atagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc cagaaccagc     1320

tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac aagagacgtg     1380

gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca     1440

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1500

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1560

cctacgacgc ccttcacatg caggccctgc cccctcgcta a                         1601


<210>  128
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  128
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  129
<211>  1487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  129
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg aacagaaact catcagtgag gaagatttgc agacgactcc aggagagaga      120

tcatcactcc ctgcctttta ccctggcact tcaggctctt gttccggatg tgggtccctc      180

tctctgccga caacaacccc tgcccccaga cctcctaccc cagcccctac aattgccagc      240

cagcctctga gcctgaggcc cgaggcttgt agacctgctg ctggcggagc cgtgcacacc      300

agaggactgg atttcgcctg cgacctaggt tctgggtgct ggtggtcgtg ggcggagtgc      360

tggcctgtta cagcctgctc gtgaccgtgg ccttcatcat cttttgggtg cggagcaaga      420

gaagcagact gctgcacagc gactacatga acatgacccc cagacggcct ggccccacca      480

gaaagcacta ccagccttac gcccctccca gagacttcgc cgcctacaga tctcccgggg      540

gaggcggagg atctggcgga ggtggaagtg gcggaggcgg atctatgagc cagagcaaca      600

gagaactggt ggtggacttc ctgagctaca agctgagcca gaagggctac agctggtccc      660

agttcagcga cgtggaagag aacagaacag aggcccctga gggcacagag tctgaggctg      720

tgaaacaggc cctgagagaa gccggcgacg agttcgagct gagatacaga agggccttca      780

gcgacctgac cagccagctg cacatcacac ctggcacagc ctaccagagc ttcgagcagg      840

tcgtgaacga gctgttcaga gatggcgtga actggggcag aatcgtggcc ttcttcagct      900

ttggcggagc cctgtgtgtg gaaagcgtgg acaaagaaat gcaggtcctg gtgtccagaa      960

tcgccgcctg gatggccacc tacctgaacg atcatctgga accctggatt caagagaacg     1020

gcggctggga caccttcgtg gaactgtacg gaaacaacgc cgctgccgag agcagaaagg     1080

gccaagaacg agaagatgga ggcggaggat ctggcggagg tggaagtggc ggaggcggat     1140

ctatgcatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa                   1487


<210>  130
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens

<400>  130

Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
1               5                   10                  15      


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
            20                  25                  30          


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
        35                  40                  45              


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
    50                  55                  60                  


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
65                  70                  75                  80  


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
                85                  90                  95      


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
            100                 105                 110         


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
        115                 120                 125             


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140                 


<210>  131
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  131

Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu Ser 
1               5                   10                  15      


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
            20                  25                  30          


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
        35                  40                  45              


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
    50                  55                  60                  


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
65                  70                  75                  80  


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
                85                  90                  95      


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
            100                 105                 110         


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
        115                 120                 125             


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140                 


<210>  132
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  132

Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
1               5                   10                  15      


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
            20                  25                  30          


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
        35                  40                  45              


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
    50                  55                  60                  


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
65                  70                  75                  80  


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
                85                  90                  95      


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
            100                 105                 110         


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly 
        115                 120                 125             


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140                 


<210>  133
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  133

Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
1               5                   10                  15      


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
            20                  25                  30          


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
        35                  40                  45              


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
    50                  55                  60                  


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
65                  70                  75                  80  


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
                85                  90                  95      


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
            100                 105                 110         


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
        115                 120                 125             


Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
    130                 135                 140                 


<210>  134
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  134

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
145                 150                 155                 160 


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
                165                 170                 175     


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
            180                 185                 190         


Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln 
        195                 200                 205             


Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln 
    210                 215                 220                 


Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu 
225                 230                 235                 240 


Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile 
                245                 250                 255     


Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly 
            260                 265                 270         


Ala 
    


<210>  135
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  135

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu 
    130                 135                 140                 


Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
145                 150                 155                 160 


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
                165                 170                 175     


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
            180                 185                 190         


Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln 
        195                 200                 205             


Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln 
    210                 215                 220                 


Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu 
225                 230                 235                 240 


Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile 
                245                 250                 255     


Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly 
            260                 265                 270         


Ala 
    


<210>  136
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  136

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
145                 150                 155                 160 


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
                165                 170                 175     


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
            180                 185                 190         


Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln 
        195                 200                 205             


Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln 
    210                 215                 220                 


Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu 
225                 230                 235                 240 


Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile 
                245                 250                 255     


Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly 
            260                 265                 270         


Ala 
    


<210>  137
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  137

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
65                  70                  75                  80  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                85                  90                  95      


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            100                 105                 110         


Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
145                 150                 155                 160 


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
                165                 170                 175     


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
            180                 185                 190         


Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln 
        195                 200                 205             


Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln 
    210                 215                 220                 


Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu 
225                 230                 235                 240 


Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile 
                245                 250                 255     


Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly 
            260                 265                 270         


Ala 
    


<210>  138
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  138

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  139
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  139

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  140
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  140

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Ala Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala 
    530                 


<210>  141
<211>  546
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  141

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Ala Tyr Leu 
    370                 375                 380                 


Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
385                 390                 395                 400 


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
                405                 410                 415     


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
            420                 425                 430         


Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln 
        435                 440                 445             


Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln 
    450                 455                 460                 


Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu 
465                 470                 475                 480 


Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile 
                485                 490                 495     


Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly 
            500                 505                 510         


Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly 
        515                 520                 525             


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
    530                 535                 540                 


Gly Pro 
545     


<210>  142
<211>  567
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  142

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Gln Arg Trp Glu Leu Ala Leu Gly Arg 
385                 390                 395                 400 


Phe Leu Ala Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln 
                405                 410                 415     


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
            420                 425                 430         


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
        435                 440                 445             


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
    450                 455                 460                 


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg 
465                 470                 475                 480 


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
                485                 490                 495     


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu 
            500                 505                 510         


Gln Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala 
        515                 520                 525             


Val Tyr Gln Ala Gly Ala Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly 
    530                 535                 540                 


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
545                 550                 555                 560 


Val Glu Glu Asn Pro Gly Pro 
                565         


<210>  143
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  143

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  144
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  144

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  145
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  145

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  146
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  146

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  147
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  147

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr 
        195                 200                 205             


Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu 
    210                 215                 220                 


Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys 
225                 230                 235                 240 


Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg 
                245                 250                 255     


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
            260                 265                 270         


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
        275                 280                 285             


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
    290                 295                 300                 


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
305                 310                 315                 320 


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
                325                 330                 335     


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala 
            340                 345                 350         


Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  148
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  148

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  149
<211>  491
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  149

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr 
        195                 200                 205             


Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu 
    210                 215                 220                 


Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys 
225                 230                 235                 240 


Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg 
                245                 250                 255     


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
            260                 265                 270         


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
        275                 280                 285             


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
    290                 295                 300                 


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
305                 310                 315                 320 


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
                325                 330                 335     


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala 
            340                 345                 350         


Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  150
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  150

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  151
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  151

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr 
        195                 200                 205             


Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu 
    210                 215                 220                 


Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys 
225                 230                 235                 240 


Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg 
                245                 250                 255     


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
            260                 265                 270         


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
        275                 280                 285             


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
    290                 295                 300                 


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
305                 310                 315                 320 


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
                325                 330                 335     


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala 
            340                 345                 350         


Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  152
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  152

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  153
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  153

Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                85                  90                  95      


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp 
            100                 105                 110         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        115                 120                 125             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu 
        195                 200                 205             


Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp 
    210                 215                 220                 


Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala 
225                 230                 235                 240 


Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr 
                245                 250                 255     


Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly 
            260                 265                 270         


Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp 
        275                 280                 285             


Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala 
    290                 295                 300                 


Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg 
305                 310                 315                 320 


Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp 
                325                 330                 335     


Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn 
            340                 345                 350         


Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  154
<211>  491
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  154

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr 
        195                 200                 205             


Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu 
    210                 215                 220                 


Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys 
225                 230                 235                 240 


Gln Ala Leu Arg Glu Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg 
                245                 250                 255     


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
            260                 265                 270         


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
        275                 280                 285             


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
    290                 295                 300                 


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
305                 310                 315                 320 


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
                325                 330                 335     


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala 
            340                 345                 350         


Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  155
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  155

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  156
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  156

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
        35                  40                  45              


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr 
    50                  55                  60                  


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
65                  70                  75                  80  


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                85                  90                  95      


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu 
            100                 105                 110         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        115                 120                 125             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    130                 135                 140                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
145                 150                 155                 160 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                165                 170                 175     


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val 
        195                 200                 205             


Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp 
    210                 215                 220                 


Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly 
225                 230                 235                 240 


Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg 
                245                 250                 255     


Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly 
            260                 265                 270         


Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu 
        275                 280                 285             


Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp 
    290                 295                 300                 


Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg 
305                 310                 315                 320 


Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn 
                325                 330                 335     


Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val 
            340                 345                 350         


Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu 
        355                 360                 365             


Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp 
    370                 375                 380                 


Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
                405                 410                 415     


His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg 
    


<210>  157
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  157

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala 
                165                 170                 175     


Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His 
            180                 185                 190         


Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly 
        195                 200                 205             


Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln 
    210                 215                 220                 


Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg 
225                 230                 235                 240 


Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro 
                245                 250                 255     


Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala 
            260                 265                 270         


Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser 
        275                 280                 285             


Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr 
    290                 295                 300                 


Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val 
305                 310                 315                 320 


Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg 
                325                 330                 335     


Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr 
            340                 345                 350         


Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp 
        355                 360                 365             


Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  158
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  158

Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
1               5                   10                  15      


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
            20                  25                  30          


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
        35                  40                  45              


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
    50                  55                  60                  


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
65                  70                  75                  80  


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
                85                  90                  95      


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  159
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  159

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  160
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  160

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  161
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  161

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Ala Arg Leu Ile Gly 
                485                 490                 495     


Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  162
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  162

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Ala Arg Leu Ile Gly Asp Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  163
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  163

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr 
145                 150                 155                 160 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln 
        195                 200                 205             


Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro 
    210                 215                 220                 


Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Arg Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Leu Glu Tyr Leu Ser 
    370                 375                 380                 


Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys Glu 
                405                 410                 415     


Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala 
            420                 425                 430         


Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala 
        435                 440                 445             


Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly Arg Leu Val Gln Tyr 
    450                 455                 460                 


Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
465                 470                 475                 480 


Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln Leu Arg Leu Ile Gly 
                485                 490                 495     


Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala Gly Ala 
            500                 505                 510         


Ala Glu Arg Lys Arg Arg Ser Gly Ser Gly Arg Ser Gly Ser Gly Glu 
        515                 520                 525             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro 
545 


<210>  164
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  164

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu 
                245                 250                 255     


Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser His Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe 
385                 390                 395                 400 


Leu Glu Tyr Leu Ser Trp Val Ser Thr Leu Ser Glu Gln Val Gln Glu 
                405                 410                 415     


Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp 
            420                 425                 430         


Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln 
        435                 440                 445             


Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu 
    450                 455                 460                 


Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg Gly 
465                 470                 475                 480 


Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser 
                485                 490                 495     


Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Ile Ala Leu Gln 
            500                 505                 510         


Leu Arg Leu Ile Gly Ala Ala Phe Asp Leu Gln Lys Arg Leu Ala Val 
        515                 520                 525             


Tyr Gln Ala Gly Ala 
    530             


<210>  165
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  165

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  166
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  166

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  167
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  167

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Gln Ser 
                165                 170                 175     


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
            180                 185                 190         


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
        195                 200                 205             


Ala Pro Glu Gly Thr Glu Ser Glu Ala Val Lys Gln Ala Leu Arg Glu 
    210                 215                 220                 


Ala Gly Asp Asp Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu 
225                 230                 235                 240 


Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu 
                245                 250                 255     


Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
            260                 265                 270         


Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp 
        275                 280                 285             


Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr 
    290                 295                 300                 


Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
305                 310                 315                 320 


Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg 
                325                 330                 335     


Lys Gly Gln Glu Arg Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  168
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens

<400>  168

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Thr Thr Pro Gly Glu 
1               5                   10                  15      


Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser 
            20                  25                  30          


Gly Cys Gly Ser Leu Ser Leu Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Pro Arg Phe Trp Val Leu Val Val Val Gly Gly 
                85                  90                  95      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            100                 105                 110         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        115                 120                 125             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    130                 135                 140                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala His Ala 
                165                 170                 175     


Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met Lys Tyr Ile His 
            180                 185                 190         


Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala Gly Asp Val Gly 
        195                 200                 205             


Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile Phe Ser Ser Gln 
    210                 215                 220                 


Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp Pro Val Ala Arg 
225                 230                 235                 240 


Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala Ala Ala Gly Pro 
                245                 250                 255     


Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Gln Ala 
            260                 265                 270         


Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met Ser 
        275                 280                 285             


Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala Thr 
    290                 295                 300                 


Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val 
305                 310                 315                 320 


Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn Arg 
                325                 330                 335     


Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu Tyr 
            340                 345                 350         


Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp Asp 
        355                 360                 365             


Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met His Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  169
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  169

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  170
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Peptide

<400>  170

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  171
<211>  63
<212>  PRT
<213>  Foot and mouth disease virus

<400>  171

Gly Ser Gly Ser Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala 
1               5                   10                  15      


Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala 
            20                  25                  30          


Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu Leu Asn Phe 
        35                  40                  45              


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
    50                  55                  60              


<210>  172
<211>  19
<212>  PRT
<213>  Amphimedon queenslandica

<400>  172

Leu Leu Cys Phe Leu Leu Leu Leu Leu Ser Gly Asp Val Glu Leu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  173
<211>  20
<212>  PRT
<213>  Amphimedon queenslandica

<400>  173

His His Phe Met Phe Leu Leu Leu Leu Leu Ala Gly Asp Ile Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  174
<211>  20
<212>  PRT
<213>  Saccoglossus kowalevskii

<400>  174

Trp Phe Leu Val Leu Leu Ser Phe Ile Leu Ser Gly Asp Ile Glu Val 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  175
<211>  20
<212>  PRT
<213>  Branchiostoma floridae

<400>  175

Lys Asn Cys Ala Met Tyr Met Leu Leu Leu Ser Gly Asp Val Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  176
<211>  20
<212>  PRT
<213>  Branchiostoma floridae

<400>  176

Met Val Ile Ser Gln Leu Met Leu Lys Leu Ala Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  177
<211>  22
<212>  PRT
<213>  porcine teschovirus-1

<400>  177

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  178
<211>  23
<212>  PRT
<213>  equine rhinitis A virus

<400>  178

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


