                         SEQUENCE LISTING

<110>  Bayer AG
 
<120>  Brain Natriuretic Peptide engrafted Antibodies

<130>  BHC 18 1 017

<160>  447   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  1

Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  2

Thr Tyr Ile Ser Asn Val Asn His Lys Pro 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  3

Ser Asn Thr Lys Val Asp Lys Lys Val 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  4

Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  5

Asp Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   


<210>  6
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  6

Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro 
1               5                   10                  15  


<210>  7
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  7

Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
1               5                   10                  


<210>  8
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  8

Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly 
1               5                   10                  15      


Gln 
    


<210>  9
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  9

Ser Val Val Val Thr Ser His Gln Ala Pro Gly Glu 
1               5                   10          


<210>  10
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  10

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  11

Gln Val Lys Leu Glu Leu Gly His Arg Ala 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  12

Val Asn His Leu Arg Ser Glu Lys Leu Thr 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  13

Ala Val Val Asn Val Arg Ala 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  14

Lys Gly Asp Lys Ile Ala Ile 
1               5           


<210>  15
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  15

Val Pro Lys Glu Lys Glu Lys Glu Lys Val 
1               5                   10  


<210>  16
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  16

Ala Thr Lys Ala Val Ser Val Leu Lys Gly Asp Gly 
1               5                   10          


<210>  17
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  17

Gln Gly Ile Ile Asn Phe Glu Gln Lys 
1               5                   


<210>  18
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  18

Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  19

Tyr Glu Lys Glu Lys Glu Lys 
1               5           


<210>  20
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  20

Gly Gly Ser Thr Pro Leu Lys Ser Leu Ala 
1               5                   10  


<210>  21
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  21

Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
1               5                   10                  


<210>  22
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  22

Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp Gly 
1               5                   10                  15      


Gln 
    


<210>  23
<211>  28
<212>  PRT
<213>  human

<400>  23

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  24
<211>  28
<212>  PRT
<213>  human

<400>  24

Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp Arg Ile Ser 
1               5                   10                  15      


Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg 
            20                  25              


<210>  25
<211>  22
<212>  PRT
<213>  human

<400>  25

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  26
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  26

Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  27
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  27

Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Pro Asp Gly Gly Ser Gly Gly 
            20              


<210>  28
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  28

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  29
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  29

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  30
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  30

Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  31

Ser Gly Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  32

Ala Lys Val His Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  33
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  33

Ala Ala Trp Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  34
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  34

Ala Lys Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  35
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  35

Ser Gly Ser Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  36
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  36

Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  37
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  37

Gly Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val Gly 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence (without ref aa)

<400>  38

Ser Val Val Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  39

Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
1               5                   10      


<210>  40
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  40

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  


<210>  41
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  41

Gly Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro 
1               5                   10                  15      


Ser 
    


<210>  42
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  42

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15  


<210>  43
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  43

Gly Ser Asn Pro Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser 
1               5                   10                  


<210>  44
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  44

Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Gly Ser 
1               5                   10                  15  


<210>  45
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  45

Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro His Val Asp Val Trp 
1               5                   10                  15      


Gly Gln 
        


<210>  46
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  46

Gly Ser Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Val 
1               5                   10                  


<210>  47
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  47

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln 
        


<210>  48
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  48

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Gly Ser 
1               5                   10                  


<210>  49
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  49

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Ser 
1               5                   10              


<210>  50
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  50

Gly Ser Ala Pro Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val 
1               5                   10                  15      


<210>  51
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal Sequence (without ref aa)

<400>  51

Gly Gly Ser Thr Pro Leu Lys Ser Leu Ala Ser 
1               5                   10      


<210>  52
<211>  54
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  52

Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala 
            20                  25                  30          


Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Gly Ser Gly Ser Gly 
    50                  


<210>  53
<211>  65
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  53

Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Pro Asp Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly 
            20                  25                  30          


Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser 
        35                  40                  45              


Phe Arg Tyr Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly 
65  


<210>  54
<211>  64
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  54

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp 
            20                  25                  30          


Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly 
        35                  40                  45              


Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro Ser 
    50                  55                  60                  


<210>  55
<211>  63
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  55

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60              


<210>  56
<211>  59
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (wo ref aas)

<400>  56

Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro Gly Ser Gly 
1               5                   10                  15      


Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile 
            20                  25                  30          


Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Asn 
        35                  40                  45              


Pro Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser 
    50                  55                  


<210>  57
<211>  63
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  57

Ser Gly Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Gly Ser 
    50                  55                  60              


<210>  58
<211>  66
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  58

Ala Lys Val His Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro His Val Asp Val Trp 
    50                  55                  60                  


Gly Gln 
65      


<210>  59
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  59

Ala Ala Trp Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp 
            20                  25                  30          


Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly 
        35                  40                  45              


Ser Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Val 
    50                  55                  60      


<210>  60
<211>  66
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  60

Ala Lys Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp 
    50                  55                  60                  


Gly Gln 
65      


<210>  61
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  61

Ser Gly Ser Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp 
            20                  25                  30          


Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly 
        35                  40                  45              


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Gly Ser 
    50                  55                  60      


<210>  62
<211>  59
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  62

Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg 
            20                  25                  30          


Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser 
        35                  40                  45              


Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Ser 
    50                  55                  


<210>  63
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  63

Gly Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val Gly 
1               5                   10                  15      


Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile 
            20                  25                  30          


Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Ala 
        35                  40                  45              


Pro Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val 
    50                  55                  60      


<210>  64
<211>  56
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal Sequence-NP-C-terminal Sequence (without ref aas)

<400>  64

Ser Val Val Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile 
            20                  25                  30          


Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser 
        35                  40                  45              


Thr Pro Leu Lys Ser Leu Ala Ser 
    50                  55      


<210>  65
<211>  447
<212>  PRT
<213>  human

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Thr Gly Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  66
<211>  217
<212>  PRT
<213>  human

<400>  66

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  67
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Ile 
        115                 120                 125             


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  68
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
        115                 120                 125             


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  69
<211>  504
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60                  


Pro Asp Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly 
65                  70                  75                  80  


Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser 
                85                  90                  95      


Phe Arg Tyr Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu 
145                 150                 155                 160 


Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                165                 170                 175     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            180                 185                 190         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        195                 200                 205             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    210                 215                 220                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
225                 230                 235                 240 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                245                 250                 255     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            260                 265                 270         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 


<210>  70
<211>  504
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Ser 
    50                  55                  60                  


Pro Asp Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly 
65                  70                  75                  80  


Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser 
                85                  90                  95      


Phe Arg Tyr Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu 
145                 150                 155                 160 


Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                165                 170                 175     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            180                 185                 190         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        195                 200                 205             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    210                 215                 220                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
225                 230                 235                 240 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                245                 250                 255     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            260                 265                 270         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 


<210>  71
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val His Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
        115                 120                 125             


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
    130                 135                 140                 


Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  72
<211>  504
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
    50                  55                  60                  


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Tyr Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Met Ser Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu 
145                 150                 155                 160 


Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                165                 170                 175     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            180                 185                 190         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        195                 200                 205             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    210                 215                 220                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
225                 230                 235                 240 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                245                 250                 255     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            260                 265                 270         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 


<210>  73
<211>  500
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro 
    50                  55                  60                  


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
65                  70                  75                  80  


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
                85                  90                  95      


Gly Ser Asn Pro Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser Thr Tyr 
            100                 105                 110         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        115                 120                 125             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu Tyr Phe Gln His 
145                 150                 155                 160 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                165                 170                 175     


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            180                 185                 190         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        195                 200                 205             


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    210                 215                 220                 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
225                 230                 235                 240 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                245                 250                 255     


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  74
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Thr Tyr Ile Ser Asn Val Asn His Lys Pro 
    50                  55                  60                  


Asp Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly 
65                  70                  75                  80  


Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe 
                85                  90                  95      


Arg Tyr Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Gly Ser 
            100                 105                 110         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        115                 120                 125             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    130                 135                 140                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu Tyr Phe 
145                 150                 155                 160 


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                165                 170                 175     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            180                 185                 190         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        195                 200                 205             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    210                 215                 220                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
225                 230                 235                 240 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                245                 250                 255     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            260                 265                 270         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly 
            500         


<210>  75
<211>  500
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp 
    50                  55                  60                  


Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg 
65                  70                  75                  80  


Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg 
                85                  90                  95      


Tyr Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Ser Thr Tyr 
            100                 105                 110         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        115                 120                 125             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu Tyr Phe Gln His 
145                 150                 155                 160 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                165                 170                 175     


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            180                 185                 190         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        195                 200                 205             


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    210                 215                 220                 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
225                 230                 235                 240 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                245                 250                 255     


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  76
<211>  501
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  76

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
    50                  55                  60                  


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Tyr Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Met Ser Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu 
145                 150                 155                 160 


Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                165                 170                 175     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
            180                 185                 190         


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        195                 200                 205             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    210                 215                 220                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
225                 230                 235                 240 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
                245                 250                 255     


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
            260                 265                 270         


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    370                 375                 380                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Leu Gly 
            500     


<210>  77
<211>  493
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe 
        35                  40                  45              


Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn 
    50                  55                  60                  


Ser Phe Arg Tyr Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Met 
65                  70                  75                  80  


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
                85                  90                  95      


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            100                 105                 110         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        115                 120                 125             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    130                 135                 140                 


Leu Thr Gly Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val 
145                 150                 155                 160 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                165                 170                 175     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            180                 185                 190         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        195                 200                 205             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    210                 215                 220                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                245                 250                 255     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490             


<210>  78
<211>  497
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  78

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Val Val Val Thr Ser His Gln Ala Pro Gly Glu Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
65                  70                  75                  80  


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
                85                  90                  95      


Gly Gly Ser Thr Pro Leu Lys Ser Leu Ala Ser Thr Tyr Tyr Ala Asp 
            100                 105                 110         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        115                 120                 125             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    130                 135                 140                 


Tyr Cys Ala Lys Leu Thr Gly Ala Glu Tyr Phe Gln His Trp Gly Gln 
145                 150                 155                 160 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                165                 170                 175     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            180                 185                 190         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        195                 200                 205             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    210                 215                 220                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
225                 230                 235                 240 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                245                 250                 255     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  79
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
        115                 120                 125             


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  80
<211>  267
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted LC

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asn Pro Asn 
                85                  90                  95      


Pro Asn Pro Asn Pro Asn Pro Asn Gly Gly Ser Gly Gly Ser Leu Arg 
            100                 105                 110         


Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser 
        115                 120                 125             


Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Asn Pro Asn Pro Asn 
    130                 135                 140                 


Pro Asn Pro Asn Pro Asn Val Phe Gly Ser Gly Thr Lys Val Thr Val 
145                 150                 155                 160 


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
                165                 170                 175     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            180                 185                 190         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
        195                 200                 205             


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
    210                 215                 220                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
225                 230                 235                 240 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                245                 250                 255     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            260                 265         


<210>  81
<211>  274
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted LC

<400>  81

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro 
    50                  55                  60                  


Asp Gly Gly Ser Gly Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly 
65                  70                  75                  80  


Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe 
                85                  90                  95      


Arg Tyr Gly Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn 
            100                 105                 110         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        115                 120                 125             


Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    130                 135                 140                 


Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe Gly 
145                 150                 155                 160 


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                165                 170                 175     


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
            180                 185                 190         


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
        195                 200                 205             


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
    210                 215                 220                 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
225                 230                 235                 240 


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
                245                 250                 255     


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
            260                 265                 270         


Cys Ser 
        


<210>  82
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  NP engrafted HC encoding construct

<400>  82
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gcgccaggcc      120

cctggaaaag gcctggaatg ggtgtccgcc atctctggca gcggcggcag cacctactac      180

gccgattctg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtac aagcgtgcac      300

caggaaacaa agaagtacca gagcagcccc gacggcggca gtggcggaag tctgagaaga      360

agctcc                                                                 366


<210>  83
<211>  525
<212>  DNA
<213>  artificial

<220>
<223>  NP engrafted HC encoding construct

<400>  83
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt tacatttggc agcggctctg gatctggctc cggaagcgga      120

tctcctgatg gtggaagcgg aggcagcctg agaagaagca gctgtttcgg cggcagaatg      180

gacagaatcg gcgcccaatc tggcctgggc tgcaacagct ttagatacgg cagctacggc      240

tccggcagtg gttccggtag tggctctgga atgagctggg ttcgacaggc ccctggcaaa      300

ggccttgaat gggtgtccgc catttctggc agcggaggct ctacctacta cgccgatagc      360

gtgaagggca gattcaccat cagccgggac aacagcaaga acaccctgta cctgcagatg      420

aactccctga gagccgagga caccgccgtg tactattgcg ccaaactgac aggcgccgag      480

tacttccagc attggggaca gggaaccctg gtcacagtct cttca                      525


<210>  84
<211>  333
<212>  DNA
<213>  human

<400>  84
cagtctgtgc tgacacagcc tcctagtgtg tctggcgccc ctggccagag agtgaccatc       60

agctgtaccg gcagcagctc caacatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca ccgcccccaa actgctgatc tacggcaaca gcaaccggcc cagcggcgtg      180

cccgatagat tttccggcag caagagcggc accagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgc cagagctacg acagcagcct gagcggcgtg      300

gtgtttggcg gcggaacaaa gctgaccgtg cta                                   333


<210>  85
<211>  98
<212>  PRT
<213>  human

<400>  85

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  86
<211>  17
<212>  PRT
<213>  human

<400>  86

Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10                  15      


Ser 
    


<210>  87
<211>  329
<212>  PRT
<213>  human

<400>  87

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  88
<211>  99
<212>  PRT
<213>  human

<400>  88

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly 
            


<210>  89
<211>  12
<212>  PRT
<213>  human

<400>  89

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10          


<210>  90
<211>  106
<212>  PRT
<213>  human

<400>  90

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  91
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  NP variant


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Xaa Cys Phe Gly Xaa Xaa Xaa Asp Arg Ile Xaa Xaa Xaa Ser Xaa Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  92
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  92

Ser Gly Phe Thr Phe Ser Ser 
1               5           


<210>  93
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  93

Ser Gly Phe Thr Phe Gly Ser Gly Ser Gly 
1               5                   10  


<210>  94
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  94

Gly Ser Gly Ser Gly Met 
1               5       


<210>  95
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  95

Ser Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10              


<210>  96
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  96

Ser Gly Ser Gly Ser Gly Ser Gly Met 
1               5                   


<210>  97
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  97

Ser Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210>  98
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  98

Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Met 
1               5                   10          


<210>  99
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  99

Ser Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  100
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  100

Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Met 
1               5                   10      


<210>  101
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  101

Ser Pro Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  102
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  102

Gly Ser Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val 
1               5                   10                  15      


Ala Met 
        


<210>  103
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  103

Ser Gly Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  104
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  104

Ser Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu 
1               5                   10                  15      


Leu Thr Ala Pro Arg 
            20      


<210>  105
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  105

Ser Gly Phe Thr Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Pro Asp Gly Gly Ser Gly Gly 
            20                  


<210>  106
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  106

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Met 
1               5                   10                  15  


<210>  107
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  107

Ser Gly Phe Thr Phe Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys 
1               5                   10                  15      


Leu Arg Ala Leu Leu Thr Ala Pro Arg 
            20                  25  


<210>  108
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  108

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Met 
1               5                   10                  


<210>  109
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  109

Ile Ser Gly Ser 
1               


<210>  110
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  110

Gly Gly Ser Thr 
1               


<210>  111
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  111

Ile Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  112

Gly Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  113
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  113

Ile Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   


<210>  114
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  114

Gly Ser Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10  


<210>  115
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  115

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10      


<210>  116
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  116

Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  117

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly 
1               5                   10          


<210>  118
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  118

Gly Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val Gly Ser Thr 
1               5                   10                  15  


<210>  119
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  119

Ile Ser Gly Ser Ala Val Val Asn Gly Gly Ser Gly Gly 
1               5                   10              


<210>  120
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  120

Gly Lys Ile Ala Ile Gly Gly Ser Thr 
1               5                   


<210>  121
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  121

Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Gly Gly 
1               5                   10                  


<210>  122
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  122

Gly Ser Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser Thr 
1               5                   10              


<210>  123
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  123

Ile Ser Gly Ser Val Val Val Thr Ser His Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  124
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  124

Gly Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10  


<210>  125
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  125

Ile Ser Gly Ser Ala Val Val Asn Val Arg Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  126
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  126

Gly Gly Asp Lys Ile Ala Ile Gly Gly Ser Thr 
1               5                   10      


<210>  127
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  127

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Gly Gly 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  128

Ile Ser Gly Leu Ala Val Gln Ile Arg Arg Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  129

Gly Gly Ser Gly Arg Glu Thr Leu Thr Leu Tyr Val Gly Ser Thr 
1               5                   10                  15  


<210>  130
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  130

Ile Ser Gly Ser Ala Val Val Asn Val Arg Ala Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210>  131
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  131

Ile Ser Gly Ser Tyr Ala Met Ser Trp Val Arg Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210>  132
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  132

Gly Ser Tyr Ala Met Ser Trp Val Arg Gln Gly Ser Thr 
1               5                   10              


<210>  133
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  133

Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro Gly Gly 
1               5                   10                  15      


<210>  134
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  134

Gly Ser Asn Pro Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser Thr 
1               5                   10                  15  


<210>  135
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  135

Ile Ser Gly Ser Ala Val Val Asn Val Arg Ala Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  136

Gly Ser Gly Asp Lys Ile Ala Ile Gly Gly Ser Thr 
1               5                   10          


<210>  137
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  137

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  138

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  139

Ile Ser Gly Ser Val Val Val Thr Ser His Gln Ala Pro Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  140

Gly Ser Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr Gly Ser Thr 
1               5                   10                  15      


<210>  141
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  141

Ile Ser Gly Arg Tyr Asn Ile Leu Lys Ile Gln Lys Val Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  142
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  142

Gly Gly Ser Gly Glu Tyr Leu Ile Thr Tyr Gln Ile Met Gly Ser Thr 
1               5                   10                  15      


<210>  143
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  143

Ile Ser Gly Arg Gln Leu Leu Phe Cys Arg Val Thr Leu Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  144

Gly Gly Ser Gly Glu Gln Ala Tyr Pro Glu Tyr Leu Ile Thr Tyr Gly 
1               5                   10                  15      


Ser Thr 
        


<210>  145
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  145

Ile Ser Val Val Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  146
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  146

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Ser Thr 
1               5                   10          


<210>  147
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  147

Ile Ser Gly Val Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  148
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  148

Gly Glu Lys Lys Lys Leu Lys Ser Leu Gly Ser Thr 
1               5                   10          


<210>  149
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  149

Gly Glu Lys Lys Lys Leu Lys Ser Gly Gly Ser Thr 
1               5                   10          


<210>  150
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  150

Ile Ser Gly Ser Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  151
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  151

Gly Glu Lys Lys Lys Gly Lys Ser Gly Gly Ser Thr 
1               5                   10          


<210>  152
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  152

Ile Ser Val Val Val Thr Ser His Gln Ala Pro Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  153
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  153

Ile Ser Val Val Val Thr Ser His Gln Ala Pro Thr Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  154
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  154

Ile Ser Val Val Val Thr Ser His Gln Ser Pro Thr Pro Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  155
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  155

Gly Gly Ser Thr Pro Leu Lys Ser Leu Ala Ser Thr 
1               5                   10          


<210>  156
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  156

Gly Ser Thr Pro Lys Leu Lys Ser Leu Ala Ser Thr 
1               5                   10          


<210>  157
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  157

Ile Ser Val Val Val Thr Ser His Pro Thr Pro Gly Glu Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  158
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  158

Ile Ser Val Val Val Thr Ser His Gln Ala Pro Ser Pro Gly Ser Thr 
1               5                   10                  15      


Gly Gly 
        


<210>  159
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  159

Ile Ser Val Val Val Thr Ser His Gln Ala Asn Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  160
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  160

Ile Ser Gly Ser Ala Val Val Asn Val Arg Ala Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  161
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  161

Gly Ser Lys Gly Asp Lys Ile Ala Ile Gly Gly Ser Thr 
1               5                   10              


<210>  162
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  162

Ile Ser Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  163
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  163

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Ser Thr 
1               5                   10              


<210>  164
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  164

Ile Ser Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  165
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  165

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Ser Thr 
1               5                   10              


<210>  166
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  166

Ile Ser Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu Thr Ala 
1               5                   10                  15      


Pro Gly 
        


<210>  167
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  167

Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  


<210>  168
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  168

Ile Ser Gly Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  169
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  169

Gly Ser Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Gly Ser Thr 
1               5                   10                  15  


<210>  170
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  170

Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  171
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  171

Ile His Pro Leu Gln Asn Arg Trp Ala Leu Trp Phe Phe Lys Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  172
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  172

Gly Gly Ser Gly Asn Leu Arg Leu Ile Ser Lys Phe Asp Thr Val Thr 
1               5                   10                  15      


<210>  173
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  173

Ile Ser Gly Ser Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  174
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  174

Gly Gly Ser Gly Lys Thr Thr Trp His Arg Ile Ser Val Phe Gly Gly 
1               5                   10                  15      


Ser Thr 
        


<210>  175
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  175

Ile Tyr Leu Glu Gly Lys Ile Asp Tyr Gly Glu Tyr Met Asp Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  176
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  176

Gly Gly Ser Asn Val Arg Arg Gln Ala Thr Thr Ile Ile Ala Asp Asn 
1               5                   10                  15      


Ile Thr 
        


<210>  177
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  177

Ile Ser Gly Ser Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  178
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  178

Gly Gly Ser Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Gly Gly 
1               5                   10                  15      


Ser Thr 
        


<210>  179
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  179

Ile Ser Gly Val Val Val Thr Ser His Gln Ala Pro Gly Glu Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  180
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  180

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Gly Ser Thr 
1               5                   10              


<210>  181
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  181

Ile Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  182
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  182

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Ser Thr 
1               5                   10                  


<210>  183
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  183

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  184
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  184

Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  


<210>  185
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  185

Ile Ser Gly Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  186
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  186

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Ser Thr 
1               5                   10                  


<210>  187
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  187

Ile Ser Gly Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  188
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  188

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Ser Thr 
1               5                   10                  


<210>  189
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  189

Ile Ser Gly Ser Val Val Val Thr Ser His Gln Ala Pro Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  190
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  190

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr Gly Ser Thr 
1               5                   10                  


<210>  191
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  191

Gly Glu Lys Pro Lys Pro Lys Pro Leu Ala Tyr Gly Ser Thr 
1               5                   10                  


<210>  192
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  192

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Thr 
1               5                   10                  


<210>  193
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  193

Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Pro Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  194
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  194

Ile Ser Gly Asp Ile Tyr Leu Ala Ile Asn Ile Thr Asn Gly Glu Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  195
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  195

Gly Gly Ser Gly Asp Ile Tyr Leu Ala Ile Asn Ile Thr Asn Gly Glu 
1               5                   10                  15      


Ser Thr 
        


<210>  196
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  196

Ile Ser Gly Ser Ala Thr Lys Ala Val Ser Val Leu Lys Gly Asp Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  197
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  197

Gly Gly Ser Gly Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Gly Gly 
1               5                   10                  15      


Ser Thr 
        


<210>  198
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  198

Ile Ser Gly Ser Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr 
1               5                   10                  15      


Ala Val Gly Gly 
            20  


<210>  199
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  199

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10              


<210>  200
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  200

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15  


<210>  201
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  201

Ile Ser Gly Ser Ser Gly Ala Val Val Asn Val Arg Ala Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  202
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  202

Gly Ser Lys Gly Asp Lys Ile Ala Ile Trp Thr Thr Gly Ser Thr 
1               5                   10                  15  


<210>  203
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  203

Ile Ser Gly Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  204
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  204

Ile Ser Gly Ser Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  205
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  205

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Gly Ser Thr 
1               5                   10                  15  


<210>  206
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  206

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  207
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  207

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  208
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  208

Gly Ser Tyr Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15  


<210>  209
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  209

Ile Ser Thr Gln Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  210
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  210

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Thr 
1               5                   10                  15  


<210>  211
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  211

Ile Ser Gly Ser Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  212
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  212

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Gly Ser Thr 
1               5                   10                  15  


<210>  213
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  213

Ile Ser Gly Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  214
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  214

Gly Ser Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Gly Ser Thr 
1               5                   10                  15  


<210>  215
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  215

Ile Ser Ala Val Gln Val Lys Leu Glu Leu Gly His Arg Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  216
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  216

Gly Ser Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Ser Thr 
1               5                   10                  15  


<210>  217
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  217

Ile Ser Gly Phe Ile Leu Pro Ile Glu Val Tyr Phe Lys Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  218
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  218

Gly Ser Pro Arg Lys Val Arg Phe Asp Tyr Asp Leu Phe Ser Thr 
1               5                   10                  15  


<210>  219
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  219

Ile Ser Gly Ser Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  220
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  220

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Gly Ser Thr 
1               5                   10                  15  


<210>  221
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  221

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15      


<210>  222
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  222

Ile Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Pro Arg 
            20  


<210>  223
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  223

Gly Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Ser Thr 
1               5                   10                  15      


<210>  224
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  224

Ile Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Pro Gly 
            20  


<210>  225
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  225

Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15      


<210>  226
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  226

Ile Ser Gly Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  227
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  227

Gly Ser Lys Thr His Thr Ser Pro Pro Ser Pro Gly Gly Ser Thr 
1               5                   10                  15  


<210>  228
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  228

Ile Ser Gly Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  229
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  229

Gly Ser Tyr Ser Ser Tyr Ala Met Ser Trp Val Arg Gly Gly Ser Thr 
1               5                   10                  15      


<210>  230
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  230

Gly Ser Tyr Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Gly Ser Thr 
1               5                   10                  15      


<210>  231
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  231

Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  232
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  232

Ile Ser Gly Ser Pro Asn Pro Asn Pro Asn Pro Asn Pro Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  233
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  233

Gly Ser Tyr Pro Asn Pro Asn Pro Asn Pro Asn Pro Ser Gly Ser Thr 
1               5                   10                  15      


<210>  234
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  234

Ile Ser Gly Pro Asn Pro Asn Lys Asn Pro Asn Pro Asn Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  235
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  235

Gly Ser Tyr Asn Pro Asn Glu Asn Pro Asn Pro Asn Pro Gly Ser Thr 
1               5                   10                  15      


<210>  236
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  236

Ile Ser Gly Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  237
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  237

Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Gly Ser Thr 
1               5                   10                  15      


<210>  238
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  238

Ile Ser Gly Ser Val Val Val Thr Ser His Gln Ala Pro Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  239
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  239

Ile Ser Gly Ser Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  240
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  240

Gly Ser Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Gly Ser Thr 
1               5                   10                  15      


<210>  241
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  241

Ile Ser Gly Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  242
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  242

Ile Ser Pro Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  243
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  243

Gly Ser Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Phe Ser Thr 
1               5                   10                  15      


<210>  244
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  244

Cys Ala Lys Ser Pro Asp Gly Gly Ser Gly Gly 
1               5                   10      


<210>  245
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  245

Gly Ser Tyr Gly 
1               


<210>  246
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  246

Gly Ser Tyr Gln His Trp Gly Gln Gly 
1               5                   


<210>  247
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  247

Cys Ala Lys Val His Gln Glu Thr Gly Gly Ser Gly Gly 
1               5                   10              


<210>  248
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  248

Gly Ser Trp His Val Gln His Trp Gly Gln Gly 
1               5                   10      


<210>  249
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  249

Cys Ala Lys Val His Gln Glu Thr Pro Asp Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  250
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  250

Gly Ser Tyr Glu Trp His Val Gln His Trp Gly Gln Gly 
1               5                   10              


<210>  251
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  251

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Gly Gly 
1               5                   10                  15      


<210>  252
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  252

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  253
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  253

Cys Thr Ser Val His Gln Glu Thr Ser Ser Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  254
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  254

Gly Ser Tyr Ser Tyr Glu Trp His Val Asp Val Trp Gly Gln Gly 
1               5                   10                  15  


<210>  255
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  255

Cys Ala Lys Thr His Thr Ser Pro Pro Ser Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  256
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  256

Gly Ser Ser Pro Pro Ser Pro Tyr Phe Gln His Trp Gly Gln Gly 
1               5                   10                  15  


<210>  257
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  257

Cys Thr Ser Val His Gln Glu Thr Lys Ser Ser Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  258
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  258

Gly Ser Tyr Ser Asn Tyr Glu Trp His Val Asp Val Trp Gly Gln Gly 
1               5                   10                  15      


<210>  259
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  259

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly 
        


<210>  260
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  260

Cys Thr Ser Val His Gln Glu Thr Lys Lys Ser Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  261
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  261

Gly Ser Tyr Ser Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly Gln 
1               5                   10                  15      


Gly 
    


<210>  262
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  262

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  263
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  263

Cys Thr Ser Val His Gln Glu Thr Lys Lys Gln Ser Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  264
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  264

Gly Ser Tyr Ser Tyr Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly 
1               5                   10                  15      


Gln Gly 
        


<210>  265
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  265

Cys Ala Lys Val His Pro Asn Pro Asn Pro Asn Pro Asn Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  266
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  266

Gly Ser Asn Pro Asn Pro Asn Pro Asn Pro His Val Asp Val Trp Gly 
1               5                   10                  15      


Gln Gly 
        


<210>  267
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  267

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210>  268
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  268

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  269
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  269

Cys Ala Lys Leu Thr Val Val Val Thr Ser His Gln Ala Pro Gly Glu 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  270
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  270

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr Phe Gln His Trp Gly 
1               5                   10                  15      


Gln Gly 
        


<210>  271
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  271

Cys Ala Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  272
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  272

Gly Ser Lys Thr His Thr Ser Pro Pro Ser Pro Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  273
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  273

Cys Ala Lys Val Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  274
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  274

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Val Gln His Trp Gly Gln 
1               5                   10                  15      


Gly 
    


<210>  275
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  275

Cys Ala Lys Val His Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  276
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  276

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr His Val Gln His Trp Gly Gln 
1               5                   10                  15      


Gly 
    


<210>  277
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  277

Cys Ala Lys Leu Thr Val Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  278
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  278

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  279
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  279

Cys Ala Lys Leu Thr Ala Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  280
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  280

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Asn Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  281
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  281

Cys Ala Lys Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  282
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  282

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  283
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  283

Gly Ser Tyr Asp Tyr Val Trp Gly Ser Tyr Ala Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  284
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  284

Cys Ala Lys Leu Thr Ser Val Val Val Thr Ser His Gln Ala Pro Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  285
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  285

Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  286
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  286

Cys Ala Lys Val His Pro Asn Pro Asn Pro Asn Pro Asn Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  287
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  287

Gly Ser Tyr Asn Pro Asn Pro Asn Pro Asn Pro His Val Asp Val Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  288
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  288

Cys Ala Lys Leu Thr Gln Val Lys Leu Glu Leu Gly His Arg Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  289
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  289

Gly Ser Asn His Leu Arg Ser Glu Lys Leu Thr Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  290
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  290

Cys Ala Lys Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  291
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  291

Cys Ala Lys Thr Gln Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  292
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  292

Gly Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Tyr Phe Gln His Trp 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  293
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  293

Gly Ser Tyr Ser Tyr Thr Thr Tyr Asn Tyr Glu Trp His Val Asp Val 
1               5                   10                  15      


Trp Gly Gln Gly 
            20  


<210>  294
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  294

Cys Ala Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  295
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  295

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val His 
1               5                   10                  15      


Trp Gly Gln Gly 
            20  


<210>  296
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  296

Cys Ala Lys Leu Thr Ala Glu Glu Trp Lys Lys Lys Tyr Glu Lys Glu 
1               5                   10                  15      


Lys Glu Lys Asn Lys Gly Ser 
            20              


<210>  297
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  297

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Glu Tyr Phe Gln 
1               5                   10                  15      


His Trp Gly Gln Gly 
            20      


<210>  298
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  298

Cys Ala Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg 
1               5                   10                  15      


Ala Leu Leu Thr Ala Pro Arg 
            20              


<210>  299
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  299

Gly Ser Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Tyr Phe Gln 
1               5                   10                  15      


His Trp Gly Gln Gly 
            20      


<210>  300
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  300

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Tyr Gln Ser Ser 
1               5                   10                  15      


Pro Asp Gly Gly Ser Gly Gly 
            20              


<210>  301
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  301

Gly Ser Tyr Ser Tyr Thr Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp 
1               5                   10                  15      


Val Trp Gly Gln Gly 
            20      


<210>  302
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  302

Cys Ala Lys Leu Thr Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg 
1               5                   10                  15      


Ala Leu Leu Thr Ala Pro Arg 
            20              


<210>  303
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  303

Cys Ala Lys Leu Thr Ala Val Gln Val Lys Leu Glu Leu Gly His Arg 
1               5                   10                  15      


Pro Asp Gly Gly Ser Gly Gly 
            20              


<210>  304
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  304

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Tyr Gln 
1               5                   10                  15      


Ser Ser Pro Asp Gly Gly Ser Gly Gly 
            20                  25  


<210>  305
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  305

Gly Ser Tyr Ser Tyr Thr Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His 
1               5                   10                  15      


Val Asp Val Trp Gly Gln Gly 
            20              


<210>  306
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  306

Cys Ala Lys Leu Thr Ala Val Gln Val Lys Leu Glu Leu Gly His Arg 
1               5                   10                  15      


Ala Gln Pro Asp Gly Gly Ser Gly Gly 
            20                  25  


<210>  307
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  307

Gly Ser Pro Val Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Tyr 
1               5                   10                  15      


Phe Gln His Trp Gly Gln Gly 
            20              


<210>  308
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  308

Ser Ser Ser Asn Ile Gly Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro 
1               5                   10                  15      


Arg 
    


<210>  309
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  309

Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Tyr Asp 
1               5                   10                  15  


<210>  310
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  310

Gly Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asp 
1               5                   10                  


<210>  311
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  311

Ser Ser Leu Gly Gln Ile Gln Leu Thr Ile Arg His Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  312
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  312

Gly Ser Asn Lys Leu Ile Val Val Val His Ala Ser Arg Asn Leu Ile 
1               5                   10                  15      


Gly Tyr Asp 
            


<210>  313
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  313

Ser Pro Leu Gly Gln Ile Gln Leu Thr Ile Arg His Ser Ser Gln Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  314
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  314

Gly Ser Arg Asn Lys Leu Ile Val Val Val His Ala Ser Arg Asn Leu 
1               5                   10                  15      


Ile Ala Tyr Asp 
            20  


<210>  315
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  315

Ser Ser Leu Gly Gln Ile Gln Leu Thr Ile Arg His Ser Ser Gln Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  316
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  316

Gly Ser Arg Asn Lys Leu Ile Val Val Val His Ala Ser Arg Asn Leu 
1               5                   10                  15      


Ile Gly Tyr Asp 
            20  


<210>  317
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  317

Ser Ser Ser Asn Ile Gly Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala 
1               5                   10                  15      


Leu Leu Thr Ala Pro Arg 
            20          


<210>  318
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  318

Gly Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu 
1               5                   10                  15      


Leu Thr Ala Asp 
            20  


<210>  319
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  319

Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Tyr Asp 
            20  


<210>  320
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  320

Ser Ser Ser Asn Ile Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Pro Asp Gly Gly Ser Gly Gly 
            20                  


<210>  321
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  321

Gly Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Tyr Asp 
1               5                   10                  15  


<210>  322
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  322

Asn Ser Asn Arg Pro Ser Gly 
1               5           


<210>  323
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  323

Tyr Gly Gly Ser Gly Ser 
1               5       


<210>  324
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  324

Gly Ser Gly Ser Asn Ser Asn Arg Pro Ser Gly 
1               5                   10      


<210>  325
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  325

Tyr Gly Lys Thr His Thr Ser Pro Pro Ser Pro Gly Gly 
1               5                   10              


<210>  326
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  326

Gly Gly Lys Thr His Thr Ser Pro Pro Ser Pro Gly Asn Arg Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  327
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  327

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Gly 
1               5                   10                  


<210>  328
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  328

Gly Gly Lys Thr His Thr Ser Pro Pro Ser Pro Ser Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  329
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  329

Tyr Gly Ser Lys Thr His Thr Ser Pro Pro Ser Pro Gly Gly 
1               5                   10                  


<210>  330
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  330

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  331
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  331

Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro Ser Gly 
1               5                   10                  15  


<210>  332
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  332

Tyr Gly Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Gly Gly 
1               5                   10                  15      


<210>  333
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  333

Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn 
1               5                   10                  15      


Arg Pro Ser Gly 
            20  


<210>  334
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  334

Tyr Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  335
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  335

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Arg Pro Ser Gly 
1               5                   10                  15      


<210>  336
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  336

Tyr Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  337
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  337

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Asn Arg Pro Ser Gly 
1               5                   10                  15      


<210>  338
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  338

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  339
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  339

Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  340
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  340

Tyr Gly Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val 
1               5                   10                  15      


Gly Gly 
        


<210>  341
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  341

Gly Ser Ala Pro Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val 
1               5                   10                  15      


Gly 
    


<210>  342
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  342

Tyr Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  343
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  343

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Asn Arg Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  344
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  344

Tyr Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  345
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  345

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  346
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  346

Gly Ser Tyr Glu Lys Glu Lys Glu Lys Asn Lys Thr Leu Lys Asn Val 
1               5                   10                  15      


Gly 
    


<210>  347
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  347

Tyr Gly Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  348
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  348

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Asn Arg Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  349
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  349

Tyr Gly Ala Glu Glu Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys 
1               5                   10                  15      


Gly Gly 
        


<210>  350
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  350

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly 
    


<210>  351
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  351

Tyr Gly Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  352
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  352

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Asn Arg Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  353
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  353

Tyr Gly Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu Thr Ala 
1               5                   10                  15      


Pro Gly 
        


<210>  354
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  354

Gly Ser Asp Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  355
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  355

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  356
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  356

Tyr Gly Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  357
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  357

Gly Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Gly Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  358
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  358

Tyr Gly Gly Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  359
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  359

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Gly Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  360
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  360

Tyr Thr Gln Thr Tyr Ile Ser Asn Val Asn His Lys Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  361
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  361

Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  362
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  362

Tyr Gly Gly Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  363
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  363

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  364
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  364

Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  365
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  365

Gly Ser Tyr Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn Arg Pro 
1               5                   10                  15      


Ser Gly 
        


<210>  366
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  366

Tyr Gly Ser Gln Val Lys Leu Glu Leu Gly His Arg Ala Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  367
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  367

Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu Thr Ser Gly Asn Arg 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  368
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  368

Tyr Pro Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  369
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  369

Gly Ser Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Phe Asn Arg 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  370
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  370

Tyr Gly Gly Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  371
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  371

Gly Ser Gly Arg Glu Val Pro Ile Ser Asn Gly Ser Gly Gly Asn Arg 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  372
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  372

Tyr Gly Ala Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  373
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  373

Tyr Gly Ser Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Pro Arg 
            20  


<210>  374
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  374

Gly Ser Asp Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Asn 
1               5                   10                  15      


Arg Pro Ser Gly 
            20  


<210>  375
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  375

Tyr Gly Ser Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Pro Gly 
            20  


<210>  376
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  376

Tyr Gly Ser Ala Val Gln Val Lys Leu Glu Leu Gly His Arg Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  377
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  377

Gly Ser Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Ser Gly Asn 
1               5                   10                  15      


Arg Pro Ser Gly 
            20  


<210>  378
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  378

Cys Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  379
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  379

Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe 
1               5                   10  


<210>  380
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  380

Cys Gln Ser Tyr Asp Ile Leu Pro Ile Glu Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  381
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  381

Gly Ser Arg Phe Asp Tyr Asp Gly Val Val Phe 
1               5                   10      


<210>  382
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  382

Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  383
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  383

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe 
1               5                   10          


<210>  384
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  384

Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  385
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  385

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe 
1               5                   10                  


<210>  386
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  386

Cys Gln Ser Tyr Asp Lys Leu Glu Leu Gly His Pro Asp Gly Gly Ser 
1               5                   10                  15      


Gly Gly 
        


<210>  387
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  387

Gly Ser His Leu Arg Ser Glu Lys Gly Val Val Phe 
1               5                   10          


<210>  388
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  388

Cys Gln Ser Tyr Asp Ile Leu Pro Ile Glu Val Tyr Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  389
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  389

Gly Ser Lys Val Arg Phe Asp Tyr Asp Gly Val Val Phe 
1               5                   10              


<210>  390
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  390

Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  391
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  391

Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Asp Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  392
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  392

Cys Gln Ser Tyr Asp Gly Phe Ile Leu Pro Ile Glu Val Tyr Gly Gly 
1               5                   10                  15      


Ser Gly Gly 
            


<210>  393
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  393

Gly Ser Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Val Val Phe 
1               5                   10                  15  


<210>  394
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  394

Cys Gln Ser Tyr Asp Lys Leu Glu Leu Gly His Arg Ala Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  395
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  395

Gly Ser Val Asn His Leu Arg Ser Glu Lys Gly Val Val Phe 
1               5                   10                  


<210>  396
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  396

Cys Gln Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  397
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  397

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Val Phe 
1               5                   10                  15  


<210>  398
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  398

Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  399
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  399

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe 
1               5                   10                  15  


<210>  400
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  400

Cys Gln Ser Tyr Asp Pro Asn Pro Asn Pro Asn Pro Asn Pro Asp Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  401
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  401

Gly Ser Asn Pro Asn Pro Asn Pro Asn Pro Ser Gly Val Val Phe 
1               5                   10                  15  


<210>  402
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  402

Cys Ala Ala Trp Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  403
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  403

Gly Ser Asn Pro Asn Pro Asn Pro Asn Pro Asn Pro Asn Val Phe 
1               5                   10                  15  


<210>  404
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  404

Cys Gln Ser Tyr Asp Gln Val Lys Leu Glu Leu Gly His Arg Ala Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  405
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  405

Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu Thr Gly Val Val Phe 
1               5                   10                  15      


<210>  406
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  406

Cys Gln Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  407
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  407

Cys Gln Ser Tyr Asp Gln Val Lys Leu Glu Leu Gly His Arg Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  408
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  408

Gly Ser Asn His Leu Arg Ser Glu Lys Leu Thr Gly Val Val Phe 
1               5                   10                  15  


<210>  409
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  409

Cys Gln Ser Tyr Asp Gly Phe Ile Leu Pro Ile Glu Val Tyr Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  410
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  410

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Phe 
1               5                   10                  15      


<210>  411
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  411

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Val Val Phe 
1               5                   10                  15      


<210>  412
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  412

Cys Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly 
            20      


<210>  413
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  413

Gly Ser Tyr Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Phe 
1               5                   10                  15      


<210>  414
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  414

Cys Gln Ser Tyr Asp Ser Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala 
1               5                   10                  15      


Leu Leu Thr Ala Pro Arg 
            20          


<210>  415
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  415

Cys Gln Ser Ala Val Gln Val Lys Leu Glu Leu Gly His Arg Ala Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  416
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  416

Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Val Phe 
1               5                   10                  15      


<210>  417
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  417

Cys Gln Ser Tyr Asp Gln Val Lys Leu Glu Leu Gly His Arg Ala Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  418
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  418

Cys Gln Ser Tyr Asp Gly Phe Ile Leu Pro Ile Glu Val Tyr Phe Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  419
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  419

Gly Ser Arg Lys Val Arg Phe Asp Tyr Asp Leu Phe Gly Val Val Phe 
1               5                   10                  15      


<210>  420
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  420

Cys Gln Ser Tyr Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro 
1               5                   10                  15      


Asp Gly Gly Ser Gly Gly 
            20          


<210>  421
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  421

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Gly Val Val 
1               5                   10                  15      


Phe 
    


<210>  422
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  422

Cys Gln Ser Tyr Asp Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser 
1               5                   10                  15      


Pro Asp Gly Gly Ser Gly Gly 
            20              


<210>  423
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  423

Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Ser Gly Val 
1               5                   10                  15      


Val Phe 
        


<210>  424
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  424

Cys Gln Ser Tyr Asp Ala Val Gln Val Lys Leu Glu Leu Gly His Arg 
1               5                   10                  15      


Ala Pro Asp Gly Gly Ser Gly Gly 
            20                  


<210>  425
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  425

Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu Thr Phe Asn Gly Val 
1               5                   10                  15      


Val Phe 
        


<210>  426
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  426

Cys Gln Ser Tyr Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys 
1               5                   10                  15      


Leu Arg Ala Leu Leu Thr Ala Pro Arg 
            20                  25  


<210>  427
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  427

Gly Ser Gly Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu Thr Gly 
1               5                   10                  15      


Val Val Phe 
            


<210>  428
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  428

Gly Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Val Val Phe 
            20      


<210>  429
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  429

Cys Gln Ser Tyr Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys 
1               5                   10                  15      


Leu Arg Ala Leu Leu Thr Ala Pro Glu 
            20                  25  


<210>  430
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  430

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly 
            20              


<210>  431
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  431

Gly Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val 
1               5                   10                  15      


Trp Gly Gln Gly 
            20  


<210>  432
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  432

Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly 
1               5                   10                  15      


Gln Gly 
        


<210>  433
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  433

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser 
            20          


<210>  434
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  434

Gly Ser Gly Gly Tyr Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp 
1               5                   10                  15      


His Val Asp Val Trp Gly Gln Gly 
            20                  


<210>  435
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  435

Cys Gln Ser Tyr Asp Gln Val Lys Leu Glu Leu Gly His Arg Ala Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


<210>  436
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  436

Gly Ser Gly Gly Ser Gly Ser Val Asn His Leu Arg Ser Glu Lys Leu 
1               5                   10                  15      


Thr Gly Val Val Phe 
            20      


<210>  437
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  437

Gly Ser Gly Gly Ser Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp 
1               5                   10                  15      


His Val Asp Val Trp Gly Gln Gly 
            20                  


<210>  438
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  438

Gly Gly Gly Ser Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His 
1               5                   10                  15      


Val Asp Val Trp Gly Gln Gly 
            20              


<210>  439
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  439

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys 
            20          


<210>  440
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal sequence (with ref aa)

<400>  440

Ile Ser Gly Ser Val Val Val Thr Ser His Gln Ala Pro Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser 
            20  


<210>  441
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal sequence (with ref aa)

<400>  441

Gly Ser Gly Gly Ser Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr 
1               5                   10                  15      


Gly Ser Thr 
            


<210>  442
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  442

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met 
        115                 120                 125             


Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  443
<211>  500
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  443

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Val Val Val Thr Ser His Gln Ala Pro Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys 
65                  70                  75                  80  


Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg 
                85                  90                  95      


Arg Gly Glu Lys Lys Lys Leu Lys Ser Leu Ala Tyr Gly Ser Thr Tyr 
            100                 105                 110         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        115                 120                 125             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Ala Lys Leu Thr Gly Ala Glu Tyr Phe Gln His 
145                 150                 155                 160 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                165                 170                 175     


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            180                 185                 190         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        195                 200                 205             


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    210                 215                 220                 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
225                 230                 235                 240 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                245                 250                 255     


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  444
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  444

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ile Thr Gly Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met 
        115                 120                 125             


Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Ala Glu Tyr Phe Gln His Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  445
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  445

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Tyr Lys 
            100                 105                 110         


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
        115                 120                 125             


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  446
<211>  499
<212>  PRT
<213>  artificial

<220>
<223>  NP engrafted HC

<400>  446

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Ser Pro Asp Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
        115                 120                 125             


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys Gly Ser Gly Gly Tyr 
    130                 135                 140                 


Gly Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                165                 170                 175     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            180                 185                 190         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        195                 200                 205             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    210                 215                 220                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
225                 230                 235                 240 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                245                 250                 255     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  447
<211>  217
<212>  PRT
<213>  human

<400>  447

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Asp Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


