                         SEQUENCE LISTING

<110>  Fraunhofer Gesellschaft zur Foerderung der angewandten 
       Forschung e.V.
       Westfaelische Wilhelms-Universitaet Muenster
 
<120>  METHOD FOR INCREASING THE YIELD OF OXIDOSQUALENE, TRITERPENES 
       AND/OR TRITERPENOIDS AND HOST CELL THEREFORE

<130>  FHG16312PCT

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  502
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Val Leu Thr Asn Lys Thr Val Ile Ser Gly Ser Lys Val Lys Ser 
1               5                   10                  15      


Leu Ser Ser Ala Gln Ser Ser Ser Ser Gly Pro Ser Ser Ser Ser Glu 
            20                  25                  30          


Glu Asp Asp Ser Arg Asp Ile Glu Ser Leu Asp Lys Lys Ile Arg Pro 
        35                  40                  45              


Leu Glu Glu Leu Glu Ala Leu Leu Ser Ser Gly Asn Thr Lys Gln Leu 
    50                  55                  60                  


Lys Asn Lys Glu Val Ala Ala Leu Val Ile His Gly Lys Leu Pro Leu 
65                  70                  75                  80  


Tyr Ala Leu Glu Lys Lys Leu Gly Asp Thr Thr Arg Ala Val Ala Val 
                85                  90                  95      


Arg Arg Lys Ala Leu Ser Ile Leu Ala Glu Ala Pro Val Leu Ala Ser 
            100                 105                 110         


Asp Arg Leu Pro Tyr Lys Asn Tyr Asp Tyr Asp Arg Val Phe Gly Ala 
        115                 120                 125             


Cys Cys Glu Asn Val Ile Gly Tyr Met Pro Leu Pro Val Gly Val Ile 
    130                 135                 140                 


Gly Pro Leu Val Ile Asp Gly Thr Ser Tyr His Ile Pro Met Ala Thr 
145                 150                 155                 160 


Thr Glu Gly Cys Leu Val Ala Ser Ala Met Arg Gly Cys Lys Ala Ile 
                165                 170                 175     


Asn Ala Gly Gly Gly Ala Thr Thr Val Leu Thr Lys Asp Gly Met Thr 
            180                 185                 190         


Arg Gly Pro Val Val Arg Phe Pro Thr Leu Lys Arg Ser Gly Ala Cys 
        195                 200                 205             


Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln Asn Ala Ile Lys Lys Ala 
    210                 215                 220                 


Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu Gln His Ile Gln Thr Cys 
225                 230                 235                 240 


Leu Ala Gly Asp Leu Leu Phe Met Arg Phe Arg Thr Thr Thr Gly Asp 
                245                 250                 255     


Ala Met Gly Met Asn Met Ile Ser Lys Gly Val Glu Tyr Ser Leu Lys 
            260                 265                 270         


Gln Met Val Glu Glu Tyr Gly Trp Glu Asp Met Glu Val Val Ser Val 
        275                 280                 285             


Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile 
    290                 295                 300                 


Glu Gly Arg Gly Lys Ser Val Val Ala Glu Ala Thr Ile Pro Gly Asp 
305                 310                 315                 320 


Val Val Arg Lys Val Leu Lys Ser Asp Val Ser Ala Leu Val Glu Leu 
                325                 330                 335     


Asn Ile Ala Lys Asn Leu Val Gly Ser Ala Met Ala Gly Ser Val Gly 
            340                 345                 350         


Gly Phe Asn Ala His Ala Ala Asn Leu Val Thr Ala Val Phe Leu Ala 
        355                 360                 365             


Leu Gly Gln Asp Pro Ala Gln Asn Val Glu Ser Ser Asn Cys Ile Thr 
    370                 375                 380                 


Leu Met Lys Glu Val Asp Gly Asp Leu Arg Ile Ser Val Ser Met Pro 
385                 390                 395                 400 


Ser Ile Glu Val Gly Thr Ile Gly Gly Gly Thr Val Leu Glu Pro Gln 
                405                 410                 415     


Gly Ala Met Leu Asp Leu Leu Gly Val Arg Gly Pro His Ala Thr Ala 
            420                 425                 430         


Pro Gly Thr Asn Ala Arg Gln Leu Ala Arg Ile Val Ala Cys Ala Val 
        435                 440                 445             


Leu Ala Gly Glu Leu Ser Leu Cys Ala Ala Leu Ala Ala Gly His Leu 
    450                 455                 460                 


Val Gln Ser His Met Thr His Asn Arg Lys Pro Ala Glu Pro Thr Lys 
465                 470                 475                 480 


Pro Asn Asn Leu Asp Ala Thr Asp Ile Asn Arg Leu Lys Asp Gly Ser 
                485                 490                 495     


Val Thr Cys Ile Lys Ser 
            500         


<210>  2
<211>  398
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Gln Asn Val Tyr Ile Val Ser Thr Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Ser Phe Gln Gly Ser Leu Ser Ser Lys Thr Ala Val Glu Leu Gly Ala 
            20                  25                  30          


Val Ala Leu Lys Gly Ala Leu Ala Lys Val Pro Glu Leu Asp Ala Ser 
        35                  40                  45              


Lys Asp Phe Asp Glu Ile Ile Phe Gly Asn Val Leu Ser Ala Asn Leu 
    50                  55                  60                  


Gly Gln Ala Pro Ala Arg Gln Val Ala Leu Ala Ala Gly Leu Ser Asn 
65                  70                  75                  80  


His Ile Val Ala Ser Thr Val Asn Lys Val Cys Ala Ser Ala Met Lys 
                85                  90                  95      


Ala Ile Ile Leu Gly Ala Gln Ser Ile Lys Cys Gly Asn Ala Asp Val 
            100                 105                 110         


Val Val Ala Gly Gly Cys Glu Ser Met Thr Asn Ala Pro Tyr Tyr Met 
        115                 120                 125             


Pro Ala Ala Arg Ala Gly Ala Lys Phe Gly Gln Thr Val Leu Val Asp 
    130                 135                 140                 


Gly Val Glu Arg Asp Gly Leu Asn Asp Ala Tyr Asp Gly Leu Ala Met 
145                 150                 155                 160 


Gly Val His Ala Glu Lys Cys Ala Arg Asp Trp Asp Ile Thr Arg Glu 
                165                 170                 175     


Gln Gln Asp Asn Phe Ala Ile Glu Ser Tyr Gln Lys Ser Gln Lys Ser 
            180                 185                 190         


Gln Lys Glu Gly Lys Phe Asp Asn Glu Ile Val Pro Val Thr Ile Lys 
        195                 200                 205             


Gly Phe Arg Gly Lys Pro Asp Thr Gln Val Thr Lys Asp Glu Glu Pro 
    210                 215                 220                 


Ala Arg Leu His Val Glu Lys Leu Arg Ser Ala Arg Thr Val Phe Gln 
225                 230                 235                 240 


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Pro Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Ile Leu Val Ser Glu Lys Val Leu Lys Glu Lys 
            260                 265                 270         


Asn Leu Lys Pro Leu Ala Ile Ile Lys Gly Trp Gly Glu Ala Ala His 
        275                 280                 285             


Gln Pro Ala Asp Phe Thr Trp Ala Pro Ser Leu Ala Val Pro Lys Ala 
    290                 295                 300                 


Leu Lys His Ala Gly Ile Glu Asp Ile Asn Ser Val Asp Tyr Phe Glu 
305                 310                 315                 320 


Phe Asn Glu Ala Phe Ser Val Val Gly Leu Val Asn Thr Lys Ile Leu 
                325                 330                 335     


Lys Leu Asp Pro Ser Lys Val Asn Val Tyr Gly Gly Ala Val Ala Leu 
            340                 345                 350         


Gly His Pro Leu Gly Cys Ser Gly Ala Arg Val Val Val Thr Leu Leu 
        355                 360                 365             


Ser Ile Leu Gln Gln Glu Gly Gly Lys Ile Gly Val Ala Ala Ile Cys 
    370                 375                 380                 


Asn Gly Gly Gly Gly Ala Ser Ser Ile Val Ile Glu Lys Ile 
385                 390                 395             


<210>  3
<211>  491
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Lys Leu Ser Thr Lys Leu Cys Trp Cys Gly Ile Lys Gly Arg Leu 
1               5                   10                  15      


Arg Pro Gln Lys Gln Gln Gln Leu His Asn Thr Asn Leu Gln Met Thr 
            20                  25                  30          


Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro Gln Asn 
        35                  40                  45              


Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys Val Asn 
    50                  55                  60                  


Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys Tyr Thr 
65                  70                  75                  80  


Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg Glu Asp 
                85                  90                  95      


Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys Ser Tyr 
            100                 105                 110         


Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
        115                 120                 125             


Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln Leu Phe 
    130                 135                 140                 


Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala Cys Tyr 
145                 150                 155                 160 


Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu Ser Asn 
                165                 170                 175     


Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile Ala Ile 
            180                 185                 190         


Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr Val Ala 
        195                 200                 205             


Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val Arg Ala 
    210                 215                 220                 


Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe Thr Ser 
225                 230                 235                 240 


Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr Val Lys 
                245                 250                 255     


Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile Ser Lys 
            260                 265                 270         


Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val Leu Lys 
        275                 280                 285             


Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu Val Thr 
    290                 295                 300                 


Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn Pro Gln 
305                 310                 315                 320 


Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr Asp Glu 
                325                 330                 335     


Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val Ala Lys 
            340                 345                 350         


Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro Thr Asn 
        355                 360                 365             


Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala Ser Leu 
    370                 375                 380                 


Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val Gly Leu 
385                 390                 395                 400 


Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys Lys Ile 
                405                 410                 415     


Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr Asn Lys 
            420                 425                 430         


Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala Ala Ile 
        435                 440                 445             


Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro Gln Gly 
    450                 455                 460                 


Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn Ile Asp 
465                 470                 475                 480 


Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
                485                 490     


<210>  4
<211>  443
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Ser Leu Pro Phe Leu Thr Ser Ala Pro Gly Lys Val Ile Ile Phe 
1               5                   10                  15      


Gly Glu His Ser Ala Val Tyr Asn Lys Pro Ala Val Ala Ala Ser Val 
            20                  25                  30          


Ser Ala Leu Arg Thr Tyr Leu Leu Ile Ser Glu Ser Ser Ala Pro Asp 
        35                  40                  45              


Thr Ile Glu Leu Asp Phe Pro Asp Ile Ser Phe Asn His Lys Trp Ser 
    50                  55                  60                  


Ile Asn Asp Phe Asn Ala Ile Thr Glu Asp Gln Val Asn Ser Gln Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Gln Gln Ala Thr Asp Gly Leu Ser Gln Glu Leu Val 
                85                  90                  95      


Ser Leu Leu Asp Pro Leu Leu Ala Gln Leu Ser Glu Ser Phe His Tyr 
            100                 105                 110         


His Ala Ala Phe Cys Phe Leu Tyr Met Phe Val Cys Leu Cys Pro His 
        115                 120                 125             


Ala Lys Asn Ile Lys Phe Ser Leu Lys Ser Thr Leu Pro Ile Gly Ala 
    130                 135                 140                 


Gly Leu Gly Ser Ser Ala Ser Ile Ser Val Ser Leu Ala Leu Ala Met 
145                 150                 155                 160 


Ala Tyr Leu Gly Gly Leu Ile Gly Ser Asn Asp Leu Glu Lys Leu Ser 
                165                 170                 175     


Glu Asn Asp Lys His Ile Val Asn Gln Trp Ala Phe Ile Gly Glu Lys 
            180                 185                 190         


Cys Ile His Gly Thr Pro Ser Gly Ile Asp Asn Ala Val Ala Thr Tyr 
        195                 200                 205             


Gly Asn Ala Leu Leu Phe Glu Lys Asp Ser His Asn Gly Thr Ile Asn 
    210                 215                 220                 


Thr Asn Asn Phe Lys Phe Leu Asp Asp Phe Pro Ala Ile Pro Met Ile 
225                 230                 235                 240 


Leu Thr Tyr Thr Arg Ile Pro Arg Ser Thr Lys Asp Leu Val Ala Arg 
                245                 250                 255     


Val Arg Val Leu Val Thr Glu Lys Phe Pro Glu Val Met Lys Pro Ile 
            260                 265                 270         


Leu Asp Ala Met Gly Glu Cys Ala Leu Gln Gly Leu Glu Ile Met Thr 
        275                 280                 285             


Lys Leu Ser Lys Cys Lys Gly Thr Asp Asp Glu Ala Val Glu Thr Asn 
    290                 295                 300                 


Asn Glu Leu Tyr Glu Gln Leu Leu Glu Leu Ile Arg Ile Asn His Gly 
305                 310                 315                 320 


Leu Leu Val Ser Ile Gly Val Ser His Pro Gly Leu Glu Leu Ile Lys 
                325                 330                 335     


Asn Leu Ser Asp Asp Leu Arg Ile Gly Ser Thr Lys Leu Thr Gly Ala 
            340                 345                 350         


Gly Gly Gly Gly Cys Ser Leu Thr Leu Leu Arg Arg Asp Ile Thr Gln 
        355                 360                 365             


Glu Gln Ile Asp Ser Phe Lys Lys Lys Leu Gln Asp Asp Phe Ser Tyr 
    370                 375                 380                 


Glu Thr Phe Glu Thr Asp Leu Gly Gly Thr Gly Cys Cys Leu Leu Ser 
385                 390                 395                 400 


Ala Lys Asn Leu Asn Lys Asp Leu Lys Ile Lys Ser Leu Val Phe Gln 
                405                 410                 415     


Leu Phe Glu Asn Lys Thr Thr Thr Lys Gln Gln Ile Asp Asp Leu Leu 
            420                 425                 430         


Leu Pro Gly Asn Thr Asn Leu Pro Trp Thr Ser 
        435                 440             


<210>  5
<211>  451
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Pro Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Glu Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Thr Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ser 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asn Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Ala Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asp Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys 
    450     


<210>  6
<211>  396
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Thr Val Tyr Thr Ala Ser Val Thr Ala Pro Val Asn Ile Ala Thr 
1               5                   10                  15      


Leu Lys Tyr Trp Gly Lys Arg Asp Thr Lys Leu Asn Leu Pro Thr Asn 
            20                  25                  30          


Ser Ser Ile Ser Val Thr Leu Ser Gln Asp Asp Leu Arg Thr Leu Thr 
        35                  40                  45              


Ser Ala Ala Thr Ala Pro Glu Phe Glu Arg Asp Thr Leu Trp Leu Asn 
    50                  55                  60                  


Gly Glu Pro His Ser Ile Asp Asn Glu Arg Thr Gln Asn Cys Leu Arg 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Arg Lys Glu Met Glu Ser Lys Asp Ala Ser Leu 
                85                  90                  95      


Pro Thr Leu Ser Gln Trp Lys Leu His Ile Val Ser Glu Asn Asn Phe 
            100                 105                 110         


Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ala Gly Phe Ala Ala Leu 
        115                 120                 125             


Val Ser Ala Ile Ala Lys Leu Tyr Gln Leu Pro Gln Ser Thr Ser Glu 
    130                 135                 140                 


Ile Ser Arg Ile Ala Arg Lys Gly Ser Gly Ser Ala Cys Arg Ser Leu 
145                 150                 155                 160 


Phe Gly Gly Tyr Val Ala Trp Glu Met Gly Lys Ala Glu Asp Gly His 
                165                 170                 175     


Asp Ser Met Ala Val Gln Ile Ala Asp Ser Ser Asp Trp Pro Gln Met 
            180                 185                 190         


Lys Ala Cys Val Leu Val Val Ser Asp Ile Lys Lys Asp Val Ser Ser 
        195                 200                 205             


Thr Gln Gly Met Gln Leu Thr Val Ala Thr Ser Glu Leu Phe Lys Glu 
    210                 215                 220                 


Arg Ile Glu His Val Val Pro Lys Arg Phe Glu Val Met Arg Lys Ala 
225                 230                 235                 240 


Ile Val Glu Lys Asp Phe Ala Thr Phe Ala Lys Glu Thr Met Met Asp 
                245                 250                 255     


Ser Asn Ser Phe His Ala Thr Cys Leu Asp Ser Phe Pro Pro Ile Phe 
            260                 265                 270         


Tyr Met Asn Asp Thr Ser Lys Arg Ile Ile Ser Trp Cys His Thr Ile 
        275                 280                 285             


Asn Gln Phe Tyr Gly Glu Thr Ile Val Ala Tyr Thr Phe Asp Ala Gly 
    290                 295                 300                 


Pro Asn Ala Val Leu Tyr Tyr Leu Ala Glu Asn Glu Ser Lys Leu Phe 
305                 310                 315                 320 


Ala Phe Ile Tyr Lys Leu Phe Gly Ser Val Pro Gly Trp Asp Lys Lys 
                325                 330                 335     


Phe Thr Thr Glu Gln Leu Glu Ala Phe Asn His Gln Phe Glu Ser Ser 
            340                 345                 350         


Asn Phe Thr Ala Arg Glu Leu Asp Leu Glu Leu Gln Lys Asp Val Ala 
        355                 360                 365             


Arg Val Ile Leu Thr Gln Val Gly Ser Gly Pro Gln Glu Thr Asn Glu 
    370                 375                 380                 


Ser Leu Ile Asp Ala Lys Thr Gly Leu Pro Lys Glu 
385                 390                 395     


<210>  7
<211>  352
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Asp Gln Leu Tyr His Glu Tyr Glu Glu Ser Val Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  8
<211>  288
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Thr Ala Asp Asn Asn Ser Met Pro His Gly Ala Val Ser Ser Tyr 
1               5                   10                  15      


Ala Lys Leu Val Gln Asn Gln Thr Pro Glu Asp Ile Leu Glu Glu Phe 
            20                  25                  30          


Pro Glu Ile Ile Pro Leu Gln Gln Arg Pro Asn Thr Arg Ser Ser Glu 
        35                  40                  45              


Thr Ser Asn Asp Glu Ser Gly Glu Thr Cys Phe Ser Gly His Asp Glu 
    50                  55                  60                  


Glu Gln Ile Lys Leu Met Asn Glu Asn Cys Ile Val Leu Asp Trp Asp 
65                  70                  75                  80  


Asp Asn Ala Ile Gly Ala Gly Thr Lys Lys Val Cys His Leu Met Glu 
                85                  90                  95      


Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser Val Phe Ile Phe 
            100                 105                 110         


Asn Glu Gln Gly Glu Leu Leu Leu Gln Gln Arg Ala Thr Glu Lys Ile 
        115                 120                 125             


Thr Phe Pro Asp Leu Trp Thr Asn Thr Cys Cys Ser His Pro Leu Cys 
    130                 135                 140                 


Ile Asp Asp Glu Leu Gly Leu Lys Gly Lys Leu Asp Asp Lys Ile Lys 
145                 150                 155                 160 


Gly Ala Ile Thr Ala Ala Val Arg Lys Leu Asp His Glu Leu Gly Ile 
                165                 170                 175     


Pro Glu Asp Glu Thr Lys Thr Arg Gly Lys Phe His Phe Leu Asn Arg 
            180                 185                 190         


Ile His Tyr Met Ala Pro Ser Asn Glu Pro Trp Gly Glu His Glu Ile 
        195                 200                 205             


Asp Tyr Ile Leu Phe Tyr Lys Ile Asn Ala Lys Glu Asn Leu Thr Val 
    210                 215                 220                 


Asn Pro Asn Val Asn Glu Val Arg Asp Phe Lys Trp Val Ser Pro Asn 
225                 230                 235                 240 


Asp Leu Lys Thr Met Phe Ala Asp Pro Ser Tyr Lys Phe Thr Pro Trp 
                245                 250                 255     


Phe Lys Ile Ile Cys Glu Asn Tyr Leu Phe Asn Trp Trp Glu Gln Leu 
            260                 265                 270         


Asp Asp Leu Ser Glu Val Glu Asn Asp Arg Gln Ile His Arg Met Leu 
        275                 280                 285             


<210>  9
<211>  731
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Thr Glu Phe Tyr Ser Asp Thr Ile Gly Leu Pro Lys Thr Asp Pro 
1               5                   10                  15      


Arg Leu Trp Arg Leu Arg Thr Asp Glu Leu Gly Arg Glu Ser Trp Glu 
            20                  25                  30          


Tyr Leu Thr Pro Gln Gln Ala Ala Asn Asp Pro Pro Ser Thr Phe Thr 
        35                  40                  45              


Gln Trp Leu Leu Gln Asp Pro Lys Phe Pro Gln Pro His Pro Glu Arg 
    50                  55                  60                  


Asn Lys His Ser Pro Asp Phe Ser Ala Phe Asp Ala Cys His Asn Gly 
65                  70                  75                  80  


Ala Ser Phe Phe Lys Leu Leu Gln Glu Pro Asp Ser Gly Ile Phe Pro 
                85                  90                  95      


Cys Gln Tyr Lys Gly Pro Met Phe Met Thr Ile Gly Tyr Val Ala Val 
            100                 105                 110         


Asn Tyr Ile Ala Gly Ile Glu Ile Pro Glu His Glu Arg Ile Glu Leu 
        115                 120                 125             


Ile Arg Tyr Ile Val Asn Thr Ala His Pro Val Asp Gly Gly Trp Gly 
    130                 135                 140                 


Leu His Ser Val Asp Lys Ser Thr Val Phe Gly Thr Val Leu Asn Tyr 
145                 150                 155                 160 


Val Ile Leu Arg Leu Leu Gly Leu Pro Lys Asp His Pro Val Cys Ala 
                165                 170                 175     


Lys Ala Arg Ser Thr Leu Leu Arg Leu Gly Gly Ala Ile Gly Ser Pro 
            180                 185                 190         


His Trp Gly Lys Ile Trp Leu Ser Ala Leu Asn Leu Tyr Lys Trp Glu 
        195                 200                 205             


Gly Val Asn Pro Ala Pro Pro Glu Thr Trp Leu Leu Pro Tyr Ser Leu 
    210                 215                 220                 


Pro Met His Pro Gly Arg Trp Trp Val His Thr Arg Gly Val Tyr Ile 
225                 230                 235                 240 


Pro Val Ser Tyr Leu Ser Leu Val Lys Phe Ser Cys Pro Met Thr Pro 
                245                 250                 255     


Leu Leu Glu Glu Leu Arg Asn Glu Ile Tyr Thr Lys Pro Phe Asp Lys 
            260                 265                 270         


Ile Asn Phe Ser Lys Asn Arg Asn Thr Val Cys Gly Val Asp Leu Tyr 
        275                 280                 285             


Tyr Pro His Ser Thr Thr Leu Asn Ile Ala Asn Ser Leu Val Val Phe 
    290                 295                 300                 


Tyr Glu Lys Tyr Leu Arg Asn Arg Phe Ile Tyr Ser Leu Ser Lys Lys 
305                 310                 315                 320 


Lys Val Tyr Asp Leu Ile Lys Thr Glu Leu Gln Asn Thr Asp Ser Leu 
                325                 330                 335     


Cys Ile Ala Pro Val Asn Gln Ala Phe Cys Ala Leu Val Thr Leu Ile 
            340                 345                 350         


Glu Glu Gly Val Asp Ser Glu Ala Phe Gln Arg Leu Gln Tyr Arg Phe 
        355                 360                 365             


Lys Asp Ala Leu Phe His Gly Pro Gln Gly Met Thr Ile Met Gly Thr 
    370                 375                 380                 


Asn Gly Val Gln Thr Trp Asp Cys Ala Phe Ala Ile Gln Tyr Phe Phe 
385                 390                 395                 400 


Val Ala Gly Leu Ala Glu Arg Pro Glu Phe Tyr Asn Thr Ile Val Ser 
                405                 410                 415     


Ala Tyr Lys Phe Leu Cys His Ala Gln Phe Asp Thr Glu Cys Val Pro 
            420                 425                 430         


Gly Ser Tyr Arg Asp Lys Arg Lys Gly Ala Trp Gly Phe Ser Thr Lys 
        435                 440                 445             


Thr Gln Gly Tyr Thr Val Ala Asp Cys Thr Ala Glu Ala Ile Lys Ala 
    450                 455                 460                 


Ile Ile Met Val Lys Asn Ser Pro Val Phe Ser Glu Val His His Met 
465                 470                 475                 480 


Ile Ser Ser Glu Arg Leu Phe Glu Gly Ile Asp Val Leu Leu Asn Leu 
                485                 490                 495     


Gln Asn Ile Gly Ser Phe Glu Tyr Gly Ser Phe Ala Thr Tyr Glu Lys 
            500                 505                 510         


Ile Lys Ala Pro Leu Ala Met Glu Thr Leu Asn Pro Ala Glu Val Phe 
        515                 520                 525             


Gly Asn Ile Met Val Glu Tyr Pro Tyr Val Glu Cys Thr Asp Ser Ser 
    530                 535                 540                 


Val Leu Gly Leu Thr Tyr Phe His Lys Tyr Phe Asp Tyr Arg Lys Glu 
545                 550                 555                 560 


Glu Ile Arg Thr Arg Ile Arg Ile Ala Ile Glu Phe Ile Lys Lys Ser 
                565                 570                 575     


Gln Leu Pro Asp Gly Ser Trp Tyr Gly Ser Trp Gly Ile Cys Phe Thr 
            580                 585                 590         


Tyr Ala Gly Met Phe Ala Leu Glu Ala Leu His Thr Val Gly Glu Thr 
        595                 600                 605             


Tyr Glu Asn Ser Ser Thr Val Arg Lys Gly Cys Asp Phe Leu Val Ser 
    610                 615                 620                 


Lys Gln Met Lys Asp Gly Gly Trp Gly Glu Ser Met Lys Ser Ser Glu 
625                 630                 635                 640 


Leu His Ser Tyr Val Asp Ser Glu Lys Ser Leu Val Val Gln Thr Ala 
                645                 650                 655     


Trp Ala Leu Ile Ala Leu Leu Phe Ala Glu Tyr Pro Asn Lys Glu Val 
            660                 665                 670         


Ile Asp Arg Gly Ile Asp Leu Leu Lys Asn Arg Gln Glu Glu Ser Gly 
        675                 680                 685             


Glu Trp Lys Phe Glu Ser Val Glu Gly Val Phe Asn His Ser Cys Ala 
    690                 695                 700                 


Ile Glu Tyr Pro Ser Tyr Arg Phe Leu Phe Pro Ile Lys Ala Leu Gly 
705                 710                 715                 720 


Met Tyr Ser Arg Ala Tyr Glu Thr His Thr Leu 
                725                 730     


<210>  10
<211>  4293
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence of Perg7::PCTR3-construct

<400>  10
gcggccgcaa tctgctgcta ttcgtgatta ctgttacaac ctaacggttt aaatgaaacc       60

tggttctgaa gggtcatttt ataacttcaa gttcccttag cctttcgatt cattttgatt      120

atgccatttc tagaccgtgt tataggcgct ggcgtttaat ttggtgtagc ttggtttagt      180

caagagttgt attagtgttc ctcgataaag tcgatgtttc cggatattgt gttaaaattt      240

caagtatgct actaatgggg taaagttgca tgattagcag agacatatgg cttgttatgg      300

ttcggcttcc tcatttttca tgcttagttt ttgtccatct cattgtacat ttctgaatcc      360

taatgcatga ctccctaaca ttactattaa attctcaata gtgaagaata agcaaaatgg      420

gaaccatgat aatttctagc tttctctcca cccctatttt aatttgcaat catatatagt      480

actttcaata gcatcttttc tagatttgat atctgcggag aatcctcagc actagtcctg      540

caggggtaac gccagggttt tcccagtcac gacgttgtaa aacgacggcc agtgagcgcg      600

cgtaatacga ctcactatag ggcgaattgg gtgcataggc cactagtgga tctgatatca      660

cctaataact tcgtatagca tacattatac gaagttatat taagggttct cgagagctcg      720

ctgtgaagat cccagcaaag gcttacaaag tgttatctct tttgagactt gttgagttga      780

acactggtgt tttcatcaaa cttaccaagg acgtgtaccc attgttgaaa cttgtatcac      840

catatattgt tatcggacaa ccttcacttg catctatccg ttctttaatc caaaagagat      900

ctagaataat gtggcaaagg ccagaagata aagaaccaaa agagataatc ttgaatgaca      960

acaatatcgt tgaagagaaa ttaggtgatg aaggtgtcat ttgtatcgag gatatcatcc     1020

atgagatttc gacgttgggc gaaaatttct cgaaatgtac tttcttccta ttaccattca     1080

aattgaacag agaagtcagt ggattcggtg ccatctcccg tttgaataaa ctgaaaatgc     1140

gcgaacaaaa caagaagact cgtcaaattt caaacgctgc cacggctcca gttatccaag     1200

tagatatcga ctcaatgatt tccaagttga attgattaac tataaaagga aaatatctgt     1260

acaatagaca tcgggctccc attggcccta cccacatatg tagaaataca ttactctatt     1320

cactactgca tttagttatg tttaacattt gatatagcag actaccgcca ggcacaatat     1380

attccccttc cctcttgcca ttcgctgtac ttgtggtgga ttccaattca gcgcagtcac     1440

gtgctagtaa tcaccgcatt tttttctttt cctttcaggc taaaaccggt tccgggcctg     1500

atccctgcac tcattttcta acggaaaacc ttcagaagca taactaccca ttccagttta     1560

gagtcatgac aggttcaaca tcagatgctt catatacttt tatatattga attatataaa     1620

tatatctatg tactctaagt aagtacatct gctttaacgc attcctacat ttgcttcgat     1680

ttatttttat tgttgatacc tatttgaaga agtaaaaagt atcccacact acacagatta     1740

taccatgtct aagaatatcg ttgtcctacc gggtgatcac gtcggtaaag aagttactga     1800

cgaagctatt aaggtcttga atgccattgc tgaagtccgt ccagaaatta agttcaattt     1860

ccaacatcac ttgatcgggg gtgctgccat cgatgccact ggcactcctt taccagatga     1920

agctctagaa gcctctaaga aagccgatgc tgtcttacta ggtgctgttg gtggtccaaa     1980

atggggtacg ggcgcagtta gaccagaaca aggtctattg aagatcagaa aggaattggg     2040

tctatacgcc aacttgagac catgtaactt tgcttctgat tctttactag atctttctcc     2100

tttgaagcct gaatatgcaa agggtaccga tttcgtcgtc gttagagaat tggttggtgg     2160

tatctacttt ggtgaaagaa aagaagatga aggtgacgga gttgcttggg actctgagaa     2220

atacagtgtt cctgaagttc aaagaattac aagaatggct gctttcttgg cattgcaaca     2280

aaacccacca ttaccaatct ggtctcttga caaggctaac gtgcttgcct cttccagatt     2340

gtggagaaag actgttgaag aaaccatcaa gactgagttc ccacaattaa ctgttcagca     2400

ccaattgatc gactctgctg ctatgatttt ggttaaatca ccaactaagc taaacggtgt     2460

tgttattacc aacaacatgt ttggtgatat tatctccgat gaagcctctg ttattccagg     2520

ttctttgggt ttattacctt ctgcatctct agcttcccta cctgacacta acaaggcatt     2580

cggtttgtac gaaccatgtc atggttctgc cccagattta ccagcaaaca aggttaaccc     2640

aattgctacc atcttatctg cagctatgat gttgaagtta tccttggatt tggttgaaga     2700

aggtagggct cttgaagaag ctgttagaaa tgtcttggat gcaggtgtca gaaccggtga     2760

ccttggtggt tctaactcta ccactgaggt tggcgatgct atcgccaagg ctgtcaagga     2820

aatcttggct taaagagtct tttgtaacga ccccgtctcc accaacttgg tatgcttgaa     2880

atctcaaggc cattacacat tcagttatgt gaacgaaagg tctttattta acgtagcata     2940

aactaaataa tacaggttcc ggttagcctg cggatctcta gacctaataa cttcgtatag     3000

catacattat acgaagttat attaagggtt gtcgacctgc agcgggatcc ggtattccaa     3060

tgagaatcgc tagaaatgct ttaccagaac tagactactt gtcgcagatc acttttgaac     3120

tgtatgagag tacggatgct tctggtcaaa aatcgcattc cattagactg aaaatgtctc     3180

ctgggtgtca tactcaagat ccgttagatg ttcaattaga tgacaggcat tatattagtt     3240

gtattccaaa gatttccctg acgaagcatt tggatatgga ctacgttcaa cagaaattga     3300

gaaacaaatt taccagggtc attatgcctc cgaaatttac accagtaaac attacgagcc     3360

ccaacttgag tttccagaaa cgcaaaacca gaagaaagtc ggtatctgtt gagaagttga     3420

agcttcctgc ctcgtccgga tcttcatcat ctacctccgt taacaagaca ttagattagt     3480

gatcacaccc aatttttaat ttagcaaccc aaaataaata agtatttact caactttttt     3540

ttaataaaaa aaaacttaat tgaattttgc tcgcgatctt taggtccggg gttttcgttg     3600

aacccttaga cgagcaaatt agcgccataa ggatatacgt cagagcacat taattagtga     3660

catataccta tataaagagc aaccttctcc gatagacttg taatttatct tatttcattt     3720

cctaacactt tggtcgaaga agagggataa gaacagacga aaacacattt aagggctata     3780

caaagatgac agaattttat tctgacacaa tcggtctacc aaagacagat ccacgtcttt     3840

ggagactgag aactgatgag ctaggccgag aaagctggga atatttaacc cctcagcaag     3900

ccgcaaacga cccaccatcc actttcacgc agtggcttct tcaagatccc aaatttcctc     3960

aacctcatcc agaaagaaat aagcattcac cagatttttc agccttcgat gcgtgtcata     4020

atggtgcatc ttttttcaaa ctgcttcaag agcctgactc aggtattttt ccgtgtcaat     4080

ataaaggacc catgttcatg acaatcggtt acgtagccgt aaactatatc gccggtattg     4140

aaattcctga gcatgagaga atagaattaa ttagatacat cgtcaataca gcacatccgg     4200

ttgatggtgg ctggggtcta cattctgttg acaaatccac cgtgtttggt acagtattga     4260

actatgtaat cttacgttta ttggggcggc cgc                                  4293


<210>  11
<211>  7256
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence of rox1::PGal1-tHMGR; PGal10-ERG13-construct

<400>  11
gcggccgcat gaatcctaaa tcctctacac ctaagattcc aagacccaag aacgcattta       60

ttctgttcag acagcactac cacaggatct taatagacga atggaccgct caaggtgtgg      120

aaatacccca taattcaaac atttctaaaa ttattggtac gaagtggaag ggcttacaac      180

cggaagataa ggcacactgg gaaaatctag cggagaagga gaaactagaa cataaaagga      240

agtatcctga atacaaatac aagccggtaa gaaagtctaa gaagaagcaa ctacttttga      300

aggaaatcga gcaacagcag cagcaacaac agaaagaaca gcagcagcag aaacagtcac      360

aaccgcaatt acaacagccc tttaacaaca atatagttct tatgaaaaga gcacattctc      420

tttcaccatc ttcctcggtg tcaagctcga acagctatca gttccaattg aacaatgatc      480

ttaagaggtt gcctattcct tctgttaata cttctaacta tatggtctcc agatcttcag      540

cactagtcct gcaggggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc      600

cagtgagcgc gcgtaatacg actcactata gggcgaattg ggtgcatagg ccactagtgg      660

atctgatatc acctaataac ttcgtatagc atacattata cgaagttata ttaagggttc      720

tcgagagctc gttttattta ggttctatcg aggagaaaaa gcgacaagaa gagatagacc      780

atggataaac tgattatgtt ctaaacactc ctcagaagct catcgaactg tcatcctgcg      840

tgaagattaa aatccaactt agaaatttcg agcttacgga gacaatcata tgggagaagc      900

aattggaaga tagaaaaaag gtactcggta cataaatata tgtgattctg ggtagaagat      960

cggtctgcat tggatggtgg taacgcattt ttttacacac attacttgcc tcgagcatca     1020

aatggtggtt attcgtggat ctatatcacg tgatttgctt aagaattgtc gttcatggtg     1080

acacttttag ctttgacatg attaagctca tctcaattga tgttatctaa agtcatttca     1140

actatctaag atgtggttgt gattgggcca ttttgtgaaa gccagtacgc cagcgtcaat     1200

acactcccgt caattagttg caccatgtcc acaaaatcat ataccagtag agctgagact     1260

catgcaagtc cggttgcatc gaaactttta cgtttaatgg atgaaaagaa gaccaatttg     1320

tgtgcttctc ttgacgttcg ttcgactgat gagctattga aacttgttga aacgttgggt     1380

ccatacattt gccttttgaa aacacacgtt gatatcttgg atgatttcag ttatgagggt     1440

actgtcgttc cattgaaagc attggcagag aaatacaagt tcttgatatt tgaggacaga     1500

aaattcgccg atatcggtaa cacagtcaaa ttacaatata catcgggcgt ttaccgtatc     1560

gcagaatggt ctgatatcac caacgcccac ggggttactg gtgctggtat tgttgctggc     1620

ttgaaacaag gtgcgcaaga ggtcaccaaa gaaccaaggg gattattgat gcttgctgaa     1680

ttgtcttcca agggttctct agcacacggt gaatatacta agggtaccgt tgatattgca     1740

aagagtgata aagatttcgt tattgggttc attgctcaga acgatatggg aggaagagaa     1800

gaagggtttg attggctaat catgacccca ggtgtaggtt tagacgacaa aggcgatgca     1860

ttgggtcagc agtacagaac cgtcgacgaa gttgtaagtg gtggatcaga tatcatcatt     1920

gttggcagag gacttttcgc caagggtaga gatcctaagg ttgaaggtga aagatacaga     1980

aatgctggat gggaagcgta ccaaaagaga atcagcgctc cccattaatt atacaggaaa     2040

cttaatagaa caaatcacat atttaatcta atagccacct gcattggcac ggtgcaacac     2100

tacttcaact tcatcttaca aaaagatcac gtgatctgtt gtattgggat ctctagacct     2160

aataacttcg tatagcatac attatacgaa gttatattaa gggttgtcga cctgcagcgt     2220

acgaagcttc agctgacgcg atgaatgcgt gcgatgagcg acctcatgct atacctgaga     2280

aagcaacctg acctacagga aagagttact caagaataag aattttcgtt ttaaaaccta     2340

agagtcactt taaaatttgt atacacttat tttttttata acttatttaa taataaaaat     2400

cataaatcat aagaaattcg cttatttaga agtgtcaaca acgtatctac caacgatttg     2460

acccttttcc atcttttcgt aaatttctgg caaggtagac aagccgacaa ccttgattgg     2520

agacttgacc aaacctctgg cgaagaattg ttaattaaga gctcagatct tatcgtcgtc     2580

atccttgtaa tccatcgata ctagtgcggc cgcttatttt ttaacatcgt aagatcttct     2640

aaatttgtca tcgatgttgg tcaagtagta aacaccactt tgcaaatgct caatggaacc     2700

ttgaggtttg aagttcttct tcaaatgggc attttctctc aattcgatgg cagcttcgta     2760

atcctttgga gtttcggtga ttctcttggc taatttgtta gtaatatcta attccttgat     2820

aatatgttgg acgtcaccaa caattttgca agaatataga gatgcagcta aaccggaacc     2880

gtaagaaaat aaaccaacac gcttgccttg taagtcgtca gatccaacat agtttaatag     2940

agatgcaaag gcggcataaa cagatgcggt gtacatgtta cctgtgtttg ttggaacaat     3000

caaagattgg gcaactctct ctttgtggaa tggcttagca acattaacaa aagttttttc     3060

aatgttctta tcggttaaag attcgtcata atcgcgagta gctaattcgg cgtcaacttc     3120

tgggaacaat tgaggattgg ctctgaaatc gttatatagt aatctaccgt atgattttgt     3180

gaccaattta caggttggaa catggaaaac gttgtagtcg aaatatttca aaacgttcaa     3240

agcatccgaa ccagcgggat cgctaaccaa ccctttagaa atagccttct tggaataact     3300

cttgtaaact tgatcaagag ccttgacgta acaagttaat gaaaaatgac catcgacgta     3360

aggatattcg ctggtgaaat ctggcttgta aaaatcgtag gcgtgttcca tgtaagaagc     3420

tcttacagag tcaaatacaa ttggagcatc aggaccgatc cacatagcaa cagtaccggc     3480

accaccggtt ggtcttgcgg cacccttatc gtagatggca atatcaccgc aaactacaat     3540

ggcgtctcta ccatcccatg cgttagattc aatccagttc aaagagttga acaacgcgtt     3600

ggtaccaccg taacaggcat taagcgtgtc aataccttcg acgtcagtgt tttcaccaaa     3660

caattgcatc aagacagact tgacagactt ggacttgtca atcagagttt cagtaccgac     3720

ttctaatcta ccaattttgt tggtgtcgat gttgtaactc ttgatcaact tagacaaaac     3780

agttagggac atcgagtaga tatcttctct gtcattgaca aaagacatgt tggtttggcc     3840

cagaccaatt gtgtatttac cttgagaaac gccatcaaat ttctctagct cagattggtt     3900

gacacattga gttgggatgt aaatttggat acctttaata ccgacatttt gaggtctggt     3960

tttttgttca gcggtctttt gtttttttag ttcagtcatt tgcaagtttg tattgtgtaa     4020

ttgttgttgc ttttgcggcc taagtcttcc tttaatacca caccaacaaa gtttagttga     4080

gagtttcata aaaaagaatt cgaattttca aaaattctta cttttttttt ggatggacgc     4140

aaagaagttt aataatcata ttacatggca ttaccaccat atacatatcc atatacatat     4200

ccatatctaa tcttacttat atgttgtgga aatgtaaaga gccccattat cttagcctaa     4260

aaaaaccttc tctttggaac tttcagtaat acgcttaact gctcattgct atattgaagt     4320

acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt     4380

cctcgtcttc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga     4440

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac     4500

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga     4560

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat     4620

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc     4680

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac     4740

ctctatactt taacgtcaag gagaaaaaac cccggatcct tttttatggt tttaaccaat     4800

aaaacagtca tttctggatc gaaagtcaaa agtttatcat ctgcgcaatc gagctcatca     4860

ggaccttcat catctagtga ggaagatgat tcccgcgata ttgaaagctt ggataagaaa     4920

atacgtcctt tagaagaatt agaagcatta ttaagtagtg gaaatacaaa acaattgaag     4980

aacaaagagg tcgctgcctt ggttattcac ggtaagttac ctttgtacgc tttggagaaa     5040

aaattaggtg atactacgag agcggttgcg gtacgtagga aggctctttc aattttggca     5100

gaagctcctg tattagcatc tgatcgttta ccatataaaa attatgacta cgaccgcgta     5160

tttggcgctt gttgtgaaaa tgttataggt tacatgcctt tgcccgttgg tgttataggc     5220

cccttggtta tcgatggtac atcttatcat ataccaatgg caactacaga gggttgtttg     5280

gtagcttctg ccatgcgtgg ctgtaaggca atcaatgctg gcggtggtgc aacaactgtt     5340

ttaactaagg atggtatgac aagaggccca gtagtccgtt tcccaacttt gaaaagatct     5400

ggtgcctgta agatatggtt agactcagaa gagggacaaa acgcaattaa aaaagctttt     5460

aactctacat caagatttgc acgtctgcaa catattcaaa cttgtctagc aggagattta     5520

ctcttcatga gatttagaac aactactggt gacgcaatgg gtatgaatat gatttctaaa     5580

ggtgtcgaat actcattaaa gcaaatggta gaagagtatg gctgggaaga tatggaggtt     5640

gtctccgttt ctggtaacta ctgtaccgac aaaaaaccag ctgccatcaa ctggatcgaa     5700

ggtcgtggta agagtgtcgt cgcagaagct actattcctg gtgatgttgt cagaaaagtg     5760

ttaaaaagtg atgtttccgc attggttgag ttgaacattg ctaagaattt ggttggatct     5820

gcaatggctg ggtctgttgg tggatttaac gcacatgcag ctaatttagt gacagctgtt     5880

ttcttggcat taggacaaga tcctgcacaa aatgttgaaa gttccaactg tataacattg     5940

atgaaagaag tggacggtga tttgagaatt tccgtatcca tgccatccat cgaagtaggt     6000

accatcggtg gtggtactgt tctagaacca caaggtgcca tgttggactt attaggtgta     6060

agaggcccgc atgctaccgc tcctggtacc aacgcacgtc aattagcaag aatagttgcc     6120

tgtgccgtct tggcaggtga attatcctta tgtgctgccc tagcagccgg ccatttggtt     6180

caaagtcata tgacccacaa caggaaacct gctgaaccaa caaaacctaa caatttggac     6240

gccactgata taaatcgttt gaaagatggg tccgtcacct gcattaaatc ctagtcgaca     6300

tggaacagaa gttgatttcc gaagaagacc tcgagtaagc ttggtaccgc ggctagctaa     6360

gatccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc cctatttatt     6420

tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt cttttttttc     6480

tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag aaggttttgg     6540

gacgctcgaa gcgcgtgcat tcttattctt gagtaactct ttcctgtagg tcaggttgct     6600

ttctcaggta tagcatgagg tcgctcatcg cacgcattcc atgcgagctc gctgaggact     6660

taaagatctt taagtggact acctttgacg catgataaga cggcaagaga cctaccacag     6720

ctgtcatctc aactaaattc tattccatat tactcagctc cacacgaccc ttcaacgaga     6780

catcattacc tcaacgtcgc tcaagctcaa ccaagggcta actcgacccc tcaattgccc     6840

tttatttcat ccattatcaa caacagcagt caaacaccgg taactacaac taccacatcc     6900

acaacaactg cgacatcttc tcctgggaaa ttctcctctt ctccgaactc ctctgtactg     6960

gagaacaaca gattaaacag tatcaacaat tcaaatcaat atttacctcc ccctctatta     7020

ccttctctgc aagattttca actggatcag taccagcagc taaagcagat gggaccaact     7080

tatattgtca aaccactgtc tcacaccagg aacaatctat tgtccacaac tacccctacg     7140

catcatcaca ttcctcatat accaaaccaa aacattcctc tacatcaaat tataaactca     7200

agcaacactg aggtcaccgc taaaactagc ctagtttctc cgaaatgagc ggccgc         7256


<210>  12
<211>  2277
<212>  DNA
<213>  unknown

<220>
<223>  lupeol synthase of the Russian dandelion Taraxacum koksaghyz

<400>  12
atgtggaagc tgaaaatagc agaaggtagt gatgatgagt ggctgaccac caccaacaac       60

cacgtcggcc gtcagcactg gcagtttgat ccggatgctg gaaccgaaga ggaacgtgct      120

cagattgaaa agattcgtct caacttcaaa cttaatcgtt ttcaattcaa acaaagtgcc      180

gacttgttaa tgcgtactca actaagaaaa gagaacccaa tcaataaaat accggatgca      240

ataaaattga atgaaacaga agaagtgaca aatgacgcag tgtcaactac actcaaaaga      300

gccattagct tttactccac cattcaagcc catgatgggc actggccagc tgagtctgct      360

ggccctttgt tcttccttcc tccattggta atagcactat atgtgactgg agcaatgaat      420

gatattctaa cacccgcaca tcagctagaa ataaaacgtt acatatacaa tcatcagaat      480

gaagatggag gttggggatt acatatagag ggtcatagca caatatttgg atcagtactt      540

agttacataa ctttaagatt acttggggaa gaagctgata gtgttgcaga ggacatggct      600

ttggttaagg ggcgtaaatg gatccttgac catggtggtg cagttgggat tccttcgtgg      660

ggaaagtttt ggcttacgat acttggagta tacgaatggg gaggctgtaa tcctatgcca      720

cccgaatttt ggctcatgcc taagtttttc ccaattcatc caggcaaaat gttgtgttat      780

tgtcgcttag tttacatgcc catgtcgtac ttatacggca aaagatttgt gggaaaaata      840

accgagttgg ttcgcgacct aaggcaagag ctttatacag acccttatga tgagattaat      900

tggaataaag cacgaaacac gtgtgcaaag gaagatctct actatccaca cccttttgtt      960

caagatatgg tatggggtgt acttcataat gtttttgaac ctgtattaac aagtcgtccg     1020

ctttccacac taagagaaaa ggctttgaaa gtcgcaatgg atcatgttca ctatgaagat     1080

aagagtagta gatatctttg cattggatgt gtggaaaagg tgttatgctt gattgcaacg     1140

tgggtggaag atccaaatgg tgatgcatat aaacgtcatc ttgctagaat tcctgactac     1200

ttttgggttg ctgaagatgg gatgaaaatg cagagttttg gatgtcaaat gtgggatgcg     1260

gcctttgcta ttcaagctat tttatctagt aatctagccg aagaatacgg cccgactctt     1320

aaaaaagcac acgagtttgt aaaagcatca caggttcgtg ataatccgcc gggagatttc     1380

agtaaaatgt acagacacac ttctaagggt gcatggacat tttccataca agatcatggt     1440

tggcaagtct ctgattgtac ggctgaaggc ttgaaggttg cacttttgta ctcccaaatg     1500

agcccagaac ttgtgggcga aaaacttgaa actgagcatc tctacgatgc tgtcaatgtc     1560

attctttcat tacaaagtga aaacggtggc tttcctgctt gggaaccaca aagggcgtat     1620

gcttggttgg agaaattcaa cccgactgaa ttctttgaag atgtgttgat cgaacgagag     1680

tatgttgaat gcacttcatc tgcaatccaa ggtttgacac tcttcaagaa gttgcaccca     1740

gggcacagaa ccaaggagat cgagcattgt atatcaagag ctataaagta cgtcgaagac     1800

acacaagaaa gtgatggttc atggtatggt tgttggggaa tttgctacac ctatggtaca     1860

tggtttgcgg tagatgcgct agtagcttgt ggtaagaact atcataactc tcccgccctt     1920

caaaaagcat gcaaatttct gttatccaaa caacttccgg atggtggatg gggagaaagt     1980

tatctttcga gctcaaataa ggtgtatacg aatttggagg gaaatcgttc gaatttagtg     2040

catacatcat gggctttaat atcacttatt aaagcgggac aggctgaaat tgatcctaca     2100

ccaatatcta atggcgtacg gcttctcatc aattcacaaa tggaagaagg ggactttcct     2160

caacaggaaa tcacaggagt gttcatgaag aactgtaacc tcaattactc atcatatcga     2220

aatatttttc ccatatgggc acttggtgaa tatcgtcgta ttgttcaaaa tatatga        2277


<210>  13
<211>  1197
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
atgtctcaga acgtttacat tgtatcgact gccagaaccc caattggttc attccagggt       60

tctctatcct ccaagacagc agtggaattg ggtgctgttg ctttaaaagg cgccttggct      120

aaggttccag aattggatgc atccaaggat tttgacgaaa ttatttttgg taacgttctt      180

tctgccaatt tgggccaagc tccggccaga caagttgctt tggctgccgg tttgagtaat      240

catatcgttg caagcacagt taacaaggtc tgtgcatccg ctatgaaggc aatcattttg      300

ggtgctcaat ccatcaaatg tggtaatgct gatgttgtcg tagctggtgg ttgtgaatct      360

atgactaacg caccatacta catgccagca gcccgtgcgg gtgccaaatt tggccaaact      420

gttcttgttg atggtgtcga aagagatggg ttgaacgatg cgtacgatgg tctagccatg      480

ggtgtacacg cagaaaagtg tgcccgtgat tgggatatta ctagagaaca acaagacaat      540

tttgccatcg aatcctacca aaaatctcaa aaatctcaaa aggaaggtaa attcgacaat      600

gaaattgtac ctgttaccat taagggattt agaggtaagc ctgatactca agtcacgaag      660

gacgaggaac ctgctagatt acacgttgaa aaattgagat ctgcaaggac tgttttccaa      720

aaagaaaacg gtactgttac tgccgctaac gcttctccaa tcaacgatgg tgctgcagcc      780

gtcatcttgg tttccgaaaa agttttgaag gaaaagaatt tgaagccttt ggctattatc      840

aaaggttggg gtgaggccgc tcatcaacca gctgatttta catgggctcc atctcttgca      900

gttccaaagg ctttgaaaca tgctggcatc gaagacatca attctgttga ttactttgaa      960

ttcaatgaag ccttttcggt tgtcggtttg gtgaacacta agattttgaa gctagaccca     1020

tctaaggtta atgtatatgg tggtgctgtt gctctaggtc acccattggg ttgttctggt     1080

gctagagtgg ttgttacact gctatccatc ttacagcaag aaggaggtaa gatcggtgtt     1140

gccgccattt gtaatggtgg tggtggtgct tcctctattg tcattgaaaa gatatga        1197


<210>  14
<211>  1476
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
atgaaactct caactaaact ttgttggtgt ggtattaaag gaagacttag gccgcaaaag       60

caacaacaat tacacaatac aaacttgcaa atgactgaac taaaaaaaca aaagaccgct      120

gaacaaaaaa ccagacctca aaatgtcggt attaaaggta tccaaattta catcccaact      180

caatgtgtca accaatctga gctagagaaa tttgatggcg tttctcaagg taaatacaca      240

attggtctgg gccaaaccaa catgtctttt gtcaatgaca gagaagatat ctactcgatg      300

tccctaactg ttttgtctaa gttgatcaag agttacaaca tcgacaccaa caaaattggt      360

agattagaag tcggtactga aactctgatt gacaagtcca agtctgtcaa gtctgtcttg      420

atgcaattgt ttggtgaaaa cactgacgtc gaaggtattg acacgcttaa tgcctgttac      480

ggtggtacca acgcgttgtt caactctttg aactggattg aatctaacgc atgggatggt      540

agagacgcca ttgtagtttg cggtgatatt gccatctacg ataagggtgc cgcaagacca      600

accggtggtg ccggtactgt tgctatgtgg atcggtcctg atgctccaat tgtatttgac      660

tctgtaagag cttcttacat ggaacacgcc tacgattttt acaagccaga tttcaccagc      720

gaatatcctt acgtcgatgg tcatttttca ttaacttgtt acgtcaaggc tcttgatcaa      780

gtttacaaga gttattccaa gaaggctatt tctaaagggt tggttagcga tcccgctggt      840

tcggatgctt tgaacgtttt gaaatatttc gactacaacg ttttccatgt tccaacctgt      900

aaattggtca caaaatcata cggtagatta ctatataacg atttcagagc caatcctcaa      960

ttgttcccag aagttgacgc cgaattagct actcgcgatt atgacgaatc tttaaccgat     1020

aagaacattg aaaaaacttt tgttaatgtt gctaagccat tccacaaaga gagagttgcc     1080

caatctttga ttgttccaac aaacacaggt aacatgtaca ccgcatctgt ttatgccgcc     1140

tttgcatctc tattaaacta tgttggatct gacgacttac aaggcaagcg tgttggttta     1200

ttttcttacg gttccggttt agctgcatct ctatattctt gcaaaattgt tggtgacgtc     1260

caacatatta tcaaggaatt agatattact aacaaattag ccaagagaat caccgaaact     1320

ccaaaggatt acgaagctgc catcgaattg agagaaaatg cccatttgaa gaagaacttc     1380

aaacctcaag gttccattga gcatttgcaa agtggtgttt actacttgac caacatcgat     1440

gacaaattta gaagatctta cgatgttaaa aaataa                               1476


<210>  15
<211>  1332
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
atgtcattac cgttcttaac ttctgcaccg ggaaaggtta ttatttttgg tgaacactct       60

gctgtgtaca acaagcctgc cgtcgctgct agtgtgtctg cgttgagaac ctacctgcta      120

ataagcgagt catctgcacc agatactatt gaattggact tcccggacat tagctttaat      180

cataagtggt ccatcaatga tttcaatgcc atcaccgagg atcaagtaaa ctcccaaaaa      240

ttggccaagg ctcaacaagc caccgatggc ttgtctcagg aactcgttag tcttttggat      300

ccgttgttag ctcaactatc cgaatccttc cactaccatg cagcgttttg tttcctgtat      360

atgtttgttt gcctatgccc ccatgccaag aatattaagt tttctttaaa gtctacttta      420

cccatcggtg ctgggttggg ctcaagcgcc tctatttctg tatcactggc cttagctatg      480

gcctacttgg gggggttaat aggatctaat gacttggaaa agctgtcaga aaacgataag      540

catatagtga atcaatgggc cttcataggt gaaaagtgta ttcacggtac cccttcagga      600

atagataacg ctgtggccac ttatggtaat gccctgctat ttgaaaaaga ctcacataat      660

ggaacaataa acacaaacaa ttttaagttc ttagatgatt tcccagccat tccaatgatc      720

ctaacctata ctagaattcc aaggtctaca aaagatcttg ttgctcgcgt tcgtgtgttg      780

gtcaccgaga aatttcctga agttatgaag ccaattctag atgccatggg tgaatgtgcc      840

ctacaaggct tagagatcat gactaagtta agtaaatgta aaggcaccga tgacgaggct      900

gtagaaacta ataatgaact gtatgaacaa ctattggaat tgataagaat aaatcatgga      960

ctgcttgtct caatcggtgt ttctcatcct ggattagaac ttattaaaaa tctgagcgat     1020

gatttgagaa ttggctccac aaaacttacc ggtgctggtg gcggcggttg ctctttgact     1080

ttgttacgaa gagacattac tcaagagcaa attgacagtt tcaaaaagaa attgcaagat     1140

gattttagtt acgagacatt tgaaacagac ttgggtggga ctggctgctg tttgttaagc     1200

gcaaaaaatt tgaataaaga tcttaaaatc aaatccctag tattccaatt atttgaaaat     1260

aaaactacca caaagcaaca aattgacgat ctattattgc caggaaacac gaatttacca     1320

tggacttcat aa                                                         1332


<210>  16
<211>  1356
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  16
atgtcagagt tgagagcctt cagtgcccca gggaaagcgt tactagctgg tggatattta       60

gttttagatc cgaaatatga agcatttgta gtcggattat cggcaagaat gcatgctgta      120

gcccatcctt acggttcatt gcaagagtct gataagtttg aagtgcgtgt gaaaagtaaa      180

caatttaaag atggggagtg gctgtaccat ataagtccta aaactggctt cattcctgtt      240

tcgataggcg gatctaagaa ccctttcatt gaaaaagtta tcgctaacgt atttagctac      300

tttaagccta acatggacga ctactgcaat agaaacttgt tcgttattga tattttctct      360

gatgatgcct accattctca ggaggacagc gttaccgaac atcgtggcaa cagaagattg      420

agttttcatt cgcacagaat tgaagaagtt cccaaaacag ggctgggctc ctcggcaggt      480

ttagtcacag ttttaactac agctttggcc tccttttttg tatcggacct ggaaaataat      540

gtagacaaat atagagaagt tattcataat ttatcacaag ttgctcattg tcaagctcag      600

ggtaaaattg gaagcgggtt tgatgtagcg gcggcagcat atggatctat cagatataga      660

agattcccac ccgcattaat ctctaatttg ccagatattg gaagtgctac ttacggcagt      720

aaactggcgc atttggttaa tgaagaagac tggaatataa cgattaaaag taaccattta      780

ccttcgggat taactttatg gatgggcgat attaagaatg gttcagaaac agtaaaactg      840

gtccagaagg taaaaaattg gtatgattcg catatgccgg aaagcttgaa aatatataca      900

gaactcgatc atgcaaattc tagatttatg gatggactat ctaaactaga tcgcttacac      960

gagactcatg acgattacag cgatcagata tttgagtctc ttgagaggaa tgactgtacc     1020

tgtcaaaagt atcctgagat cacagaagtt agagatgcag ttgccacaat tagacgttcc     1080

tttagaaaaa taactaaaga atctggtgcc gatatcgaac ctcccgtaca aactagctta     1140

ttggatgatt gccagacctt aaaaggagtt cttacttgct taatacctgg tgctggtggt     1200

tatgacgcca ttgcagtgat tgctaagcaa gatgttgatc ttagggctca aaccgctgat     1260

gacaaaagat tttctaaggt tcaatggctg gatgtaactc aggctgactg gggtgttagg     1320

aaagaaaaag atccggaaac ttatcttgat aaataa                               1356


<210>  17
<211>  1191
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  17
atgaccgttt acacagcatc cgttaccgca cccgtcaaca tcgcaaccct taagtattgg       60

gggaaaaggg acacgaagtt gaatctgccc accaattcgt ccatatcagt gactttatcg      120

caagatgacc tcagaacgtt gacctctgcg gctactgcac ctgagtttga acgcgacact      180

ttgtggttaa atggagaacc acacagcatc gacaatgaaa gaactcaaaa ttgtctgcgc      240

gacctacgcc aattaagaaa ggaaatggaa tcgaaggacg cctcattgcc cacattatct      300

caatggaaac tccacattgt ctccgaaaat aactttccta cagcagctgg tttagcttcc      360

tccgctgctg gctttgctgc attggtctct gcaattgcta agttatacca attaccacag      420

tcaacttcag aaatatctag aatagcaaga aaggggtctg gttcagcttg tagatcgttg      480

tttggcggat acgtggcctg ggaaatggga aaagctgaag atggtcatga ttccatggca      540

gtacaaatcg cagacagctc tgactggcct cagatgaaag cttgtgtcct agttgtcagc      600

gatattaaaa aggatgtgag ttccactcag ggtatgcaat tgaccgtggc aacctccgaa      660

ctatttaaag aaagaattga acatgtcgta ccaaagagat ttgaagtcat gcgtaaagcc      720

attgttgaaa aagatttcgc cacctttgca aaggaaacaa tgatggattc caactctttc      780

catgccacat gtttggactc tttccctcca atattctaca tgaatgacac ttccaagcgt      840

atcatcagtt ggtgccacac cattaatcag ttttacggag aaacaatcgt tgcatacacg      900

tttgatgcag gtccaaatgc tgtgttgtac tacttagctg aaaatgagtc gaaactcttt      960

gcatttatct ataaattgtt tggctctgtt cctggatggg acaagaaatt tactactgag     1020

cagcttgagg ctttcaacca tcaatttgaa tcatctaact ttactgcacg tgaattggat     1080

cttgagttgc aaaaggatgt tgccagagtg attttaactc aagtcggttc aggcccacaa     1140

gaaacaaacg aatctttgat tgacgcaaag actggtctac caaaggaata a              1191


<210>  18
<211>  1059
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  18
atggcttcag aaaaagaaat taggagagag agattcttga acgttttccc taaattagta       60

gaggaattga acgcatcgct tttggcttac ggtatgccta aggaagcatg tgactggtat      120

gcccactcat tgaactacaa cactccaggc ggtaagttaa atagaggttt gtccgttgtg      180

gacacgtatg ctattctctc caacaagacc gttgaacaat tggggcaaga agaatacgaa      240

aaggttgcta ttctaggttg gtgcattgag ttgttgcagg cttacttctt ggtcgccgat      300

gatatgatgg acaagtccat taccagaaga ggccaaccat gttggtacaa ggttcctgaa      360

gttggggaaa ttgccatcaa tgacgcattc atgttagagg ctgctatcta caagcttttg      420

aaatctcact tcagaaacga aaaatactac atagatatca ccgaattgtt ccatgaagtc      480

accttccaaa ccgaattggg ccaattgatg gacttaatca ctgcacctga agacaaagtc      540

gacttgagta agttctccct aaagaagcac tccttcatag ttactttcaa gactgcttac      600

tattctttct acttgcctgt cgcattggct atgtacgttg ccggtatcac agatgaaaag      660

gatttgaaac aagccagaga tgtcttgatt ccattgggtg aatatttcca aattcaagat      720

gactacttag actgcttcgg taccccagaa cagatcggta agatcggtac agatatccaa      780

gataacaaat gttcttgggt aatcaacaag gcattagaac ttgcttccgc agaacaaaga      840

aagactttag acgaaaatta cggtaagaag gactcagtcg cagaagccaa atgcaaaaag      900

attttcaatg acttgaaaat cgaccagtta taccacgaat atgaagagtc tgttgccaag      960

gatttgaagg ccaagatctc ccaagtcgac gagtctcgtg gcttcaaagc cgacgtctta     1020

actgcgtttt tgaacaaggt ttacaagaga agtaaataa                            1059


<210>  19
<211>  867
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  19
atgactgccg acaacaatag tatgccccat ggtgcagtat ctagttacgc caaattagtg       60

caaaaccaaa cacctgaaga cattttggaa gagtttcctg aaattattcc attacaacaa      120

agacctaata cccgatctag tgagacgtca aatgacgaaa gcggagaaac atgtttttct      180

ggtcatgatg aggagcaaat taagttaatg aatgaaaatt gtattgtttt ggattgggac      240

gataatgcta ttggtgccgg taccaagaaa gtttgtcatt taatggaaaa tattgaaaag      300

ggtttactac atcgtgcatt ctccgtcttt attttcaatg aacaaggtga attactttta      360

caacaaagag ccactgaaaa aataactttc cctgatcttt ggactaacac atgctgctct      420

catccactat gtattgatga cgaattaggt ttgaagggta agctagacga taagattaag      480

ggcgctatta ctgcggcggt gagaaaacta gatcatgaat taggtattcc agaagatgaa      540

actaagacaa ggggtaagtt tcacttttta aacagaatcc attacatggc accaagcaat      600

gaaccatggg gtgaacatga aattgattac atcctatttt ataagatcaa cgctaaagaa      660

aacttgactg tcaacccaaa cgtcaatgaa gttagagact tcaaatgggt ttcaccaaat      720

gatttgaaaa ctatgtttgc tgacccaagt tacaagttta cgccttggtt taagattatt      780

tgcgagaatt acttattcaa ctggtgggag caattagatg acctttctga agtggaaaat      840

gacaggcaaa ttcatagaat gctataa                                          867


<210>  20
<211>  2196
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  20
atgacagaat tttattctga cacaatcggt ctaccaaaga cagatccacg tctttggaga       60

ctgagaactg atgagctagg ccgagaaagc tgggaatatt taacccctca gcaagccgca      120

aacgacccac catccacttt cacgcagtgg cttcttcaag atcccaaatt tcctcaacct      180

catccagaaa gaaataagca ttcaccagat ttttcagcct tcgatgcgtg tcataatggt      240

gcatcttttt tcaaactgct tcaagagcct gactcaggta tttttccgtg tcaatataaa      300

ggacccatgt tcatgacaat cggttacgta gccgtaaact atatcgccgg tattgaaatt      360

cctgagcatg agagaataga attaattaga tacatcgtca atacagcaca tccggttgat      420

ggtggctggg gtctacattc tgttgacaaa tccaccgtgt ttggtacagt attgaactat      480

gtaatcttac gtttattggg tctacccaag gaccacccgg tttgcgccaa ggcaagaagc      540

acattgttaa ggttaggcgg tgctattgga tcccctcact ggggaaaaat ttggctaagt      600

gcactaaact tgtataaatg ggaaggtgtg aaccctgccc ctcctgaaac ttggttactt      660

ccatattcac tgcccatgca tccggggaga tggtgggttc atactagagg tgtttacatt      720

ccggtcagtt acctgtcatt ggtcaaattt tcttgcccaa tgactcctct tcttgaagaa      780

ctgaggaatg aaatttacac taaaccgttt gacaagatta acttctccaa gaacaggaat      840

accgtatgtg gagtagacct atattacccc cattctacta ctttgaatat tgcgaacagc      900

cttgtagtat tttacgaaaa atacctaaga aaccggttca tttactctct atccaagaag      960

aaggtttatg atctaatcaa aacggagtta cagaatactg attccttgtg tatagcacct     1020

gttaaccagg cgttttgcgc acttgtcact cttattgaag aaggggtaga ctcggaagcg     1080

ttccagcgtc tccaatatag gttcaaggat gcattgttcc atggtccaca gggtatgacc     1140

attatgggaa caaatggtgt gcaaacctgg gattgtgcgt ttgccattca atactttttc     1200

gtcgcaggcc tcgcagaaag acctgaattc tataacacaa ttgtctctgc ctataaattc     1260

ttgtgtcatg ctcaatttga caccgagtgc gttccaggta gttataggga taagagaaag     1320

ggggcttggg gcttctcaac aaaaacacag ggctatacag tggcagattg cactgcagaa     1380

gcaattaaag ccatcatcat ggtgaaaaac tctcccgtct ttagtgaagt acaccatatg     1440

attagcagtg aacgtttatt tgaaggcatt gatgtgttat tgaacctaca aaacatcgga     1500

tcttttgaat atggttcctt tgcaacctat gaaaaaatca aggccccact agcaatggaa     1560

accttgaatc ctgctgaagt ttttggtaac ataatggtag aatacccata cgtggaatgt     1620

actgattcat ccgttctggg gttgacatat tttcacaagt acttcgacta taggaaagag     1680

gaaatacgta cacgcatcag aatcgccatc gaattcataa aaaaatctca attaccagat     1740

ggaagttggt atggaagctg gggtatttgt tttacatatg ccggtatgtt tgcattggag     1800

gcattacaca ccgtggggga gacctatgag aattcctcaa cggtaagaaa aggttgcgac     1860

ttcttggtca gtaaacagat gaaggatggc ggttgggggg aatcaatgaa gtccagtgaa     1920

ttacatagtt atgtggatag tgaaaaatcg ctagtcgttc aaaccgcatg ggcgctaatt     1980

gcacttcttt tcgctgaata tcctaataaa gaagtcatcg accgcggtat tgacctttta     2040

aaaaatagac aagaagaatc cggggaatgg aaatttgaaa gtgtagaagg tgttttcaac     2100

cactcttgtg caattgaata cccaagttat cgattcttat tccctattaa ggcattaggt     2160

atgtacagca gggcatatga aacacatacg ctttaa                               2196


<210>  21
<211>  757
<212>  PRT
<213>  Nicotiana tabacum

<400>  21

Met Trp Lys Leu Lys Ile Ala Glu Gly Gly Asn Pro Trp Leu Arg Thr 
1               5                   10                  15      


Thr Asn Asn His Val Gly Arg Glu Leu Trp Glu Phe Asp Pro Glu Leu 
            20                  25                  30          


Gly Ser Pro Glu Asp Arg Ala Glu Ile Asp Lys Phe Arg Glu His Phe 
        35                  40                  45              


His Lys His Arg Phe Glu Gln Lys His Ser Ala Asp Leu Ile Met Arg 
    50                  55                  60                  


Tyr Gln Leu Ser Lys Glu Asn Pro Gly Ile Thr Ile Leu Pro Gln Val 
65                  70                  75                  80  


Lys Val Gln Gly Asn Glu Asp Ile Thr Glu Asp Thr Val Ala Thr Thr 
                85                  90                  95      


Leu Arg Arg Ala Leu Ser Phe Tyr Ser Thr Leu Gln Thr His Asp Gly 
            100                 105                 110         


His Trp Ala Gly Asp Tyr Gly Gly Pro Met Phe Leu Met Pro Gly Met 
        115                 120                 125             


Val Ile Ala Leu Ser Val Thr Gly Ala Leu Asn Ala Val Leu Thr Ser 
    130                 135                 140                 


Glu His Lys Arg Glu Met Ile Arg Tyr Leu Tyr Asn His Gln Asn Ser 
145                 150                 155                 160 


Asp Gly Gly Trp Gly Leu His Ile Glu Gly His Ser Thr Met Phe Gly 
                165                 170                 175     


Ser Val Leu Ser Tyr Val Thr Leu Arg Leu Leu Gly Glu Gly Ala Asn 
            180                 185                 190         


Asp Gly Glu Gly Ala Met Glu Lys Gly Arg Lys Trp Ile Leu Asp His 
        195                 200                 205             


Gly Ser Ala Thr Ala Ile Thr Ser Trp Gly Lys Met Trp Leu Thr Val 
    210                 215                 220                 


Leu Gly Ala Phe Asp Trp Ser Gly Asn Asn Pro Leu Pro Pro Glu Ile 
225                 230                 235                 240 


Trp Leu Leu Pro Tyr Phe Leu Pro Ile His Pro Gly Arg Met Trp Cys 
                245                 250                 255     


His Cys Arg Met Val Tyr Leu Pro Met Cys Tyr Leu Tyr Gly Lys Arg 
            260                 265                 270         


Phe Val Gly Pro Ile Thr Pro Thr Val Leu Ser Leu Arg Lys Glu Leu 
        275                 280                 285             


Phe Thr Val Pro Tyr His Glu Ile Asp Trp Asn Lys Ala Arg Asn Glu 
    290                 295                 300                 


Cys Ala Lys Glu Asp Leu Tyr Tyr Pro His Pro Leu Val Gln Asp Ile 
305                 310                 315                 320 


Leu Trp Ala Ser Leu His Lys Val Val Glu Pro Ile Leu Met His Trp 
                325                 330                 335     


Pro Gly Lys Arg Leu Arg Glu Lys Ala Leu Arg Ile Val Met Glu His 
            340                 345                 350         


Ile His Tyr Glu Asp Glu Asn Thr Arg Tyr Ile Cys Ile Gly Pro Val 
        355                 360                 365             


Asn Lys Ile Leu Asn Met Leu Cys Cys Trp Val Glu Asp Pro Asn Ser 
    370                 375                 380                 


Glu Ala Phe Lys Leu His Leu Pro Arg Ile His Asp Tyr Met Trp Val 
385                 390                 395                 400 


Ala Glu Asp Gly Met Lys Ile Lys Gly Tyr Asn Gly Ser Gln Ser Trp 
                405                 410                 415     


Asp Thr Ser Phe Ala Ile Gln Ala Ile Ile Ala Thr Glu Leu Gly Glu 
            420                 425                 430         


Glu Tyr Gly Ser Ala Leu Arg Lys Ala His Ser Phe Ile Lys Asn Thr 
        435                 440                 445             


Gln Val Leu Asp Asp Cys Pro Gly Asn Leu Asp Phe Trp Tyr Arg His 
    450                 455                 460                 


Ile Ser Lys Gly Ala Trp Pro Phe Ser Thr Ala Asp His Gly Trp Pro 
465                 470                 475                 480 


Ile Ser Asp Cys Thr Ala Glu Gly Leu Lys Ala Thr Leu Leu Leu Ser 
                485                 490                 495     


Lys Leu Pro Ser Glu Ile Val Gly Asp Pro Leu Asp Ala Lys Arg Phe 
            500                 505                 510         


Tyr Asp Ala Val Asn Val Leu Leu Ser Leu Gln Asn Ser Gly Gly Gly 
        515                 520                 525             


Phe Ala Thr Tyr Glu Leu Ser Arg Ser Tyr Pro Trp Leu Glu Ile Ile 
    530                 535                 540                 


Asn Pro Ala Glu Thr Phe Gly Asp Ile Val Ile Asp Tyr Pro Tyr Val 
545                 550                 555                 560 


Glu Cys Ser Ser Ala Ala Ile Gln Ala Leu Thr Ala Phe Lys Lys Leu 
                565                 570                 575     


Tyr Pro Gly His Arg Lys Glu Glu Val Glu Arg Cys Ile Ala Lys Ala 
            580                 585                 590         


Ala Ala Phe Ile Glu Lys Ile Gln Glu Ala Asp Gly Ser Trp Tyr Gly 
        595                 600                 605             


Ser Trp Ala Val Cys Phe Thr Tyr Gly Thr Trp Phe Gly Val Leu Gly 
    610                 615                 620                 


Leu Leu Ala Ala Gly Arg Asn Tyr Thr Asn Ser Ser Ser Ile Arg Lys 
625                 630                 635                 640 


Ala Cys Asp Phe Leu Leu Ser Lys Gln Ile Ser Ser Gly Gly Trp Gly 
                645                 650                 655     


Glu Ser Tyr Leu Ser Cys Gln Asn Lys Val Tyr Thr Asn Leu Glu Gly 
            660                 665                 670         


Asn Arg Tyr His Val Val Asn Thr Ser Trp Ala Met Leu Thr Leu Ile 
        675                 680                 685             


Ala Ala Gly Gln Ala Glu Arg Asn Pro Thr Pro Leu His His Ala Ala 
    690                 695                 700                 


Lys Ala Leu Ile Asn Ala Gln Leu Glu Asn Gly Asp Phe Pro Gln Gln 
705                 710                 715                 720 


Glu Ile Ser Gly Val Phe Asn Arg Asn Cys Met Ile Ser Tyr Ser Ala 
                725                 730                 735     


Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Glu Tyr Arg Ser Arg 
            740                 745                 750         


Val Leu Lys Ala Lys 
        755         


<210>  22
<211>  2274
<212>  DNA
<213>  Nicotiana tabacum

<400>  22
atgtggaagt tgaagatagc agaaggaggg aatccatggc ttagaacaac aaacaatcat       60

gtaggtaggg aactatggga gtttgatcca gaactcggat ctccggaaga tcgagcggag      120

atcgacaagt ttcgcgagca tttccacaaa catcgctttg agcaaaagca tagtgctgat      180

ctcattatgc gttatcagct atcaaaggag aatccaggaa ttactatttt gccccaagtc      240

aaagtacaag gcaatgaaga tattacagaa gatactgtag ctaccacgct cagaagagca      300

ctaagttttt attccactct acaaactcat gatggtcatt gggctggaga ttatggaggg      360

ccgatgtttc taatgcctgg catggtcatt gctctatctg ttacgggggc actcaatgca      420

gtattaacaa gcgaacataa acgtgaaatg attcgatatc tttataacca tcagaacagt      480

gatggtggat ggggcttgca cattgagggc cacagcacca tgtttggttc tgttttgagc      540

tatgttactc taaggttact tggagaagga gctaatgatg gagaaggggc catggagaag      600

ggccgtaaat ggattctgga tcatggtagt gccacggcca ttacttcatg ggggaaaatg      660

tggctcacag tgcttggagc attcgactgg tctgggaaca atccactccc tccggaaata      720

tggcttcttc cctacttcct tccaattcat cctggaagaa tgtggtgtca ctgcaggatg      780

gtttatcttc ctatgtgcta cctgtatggt aaaaggttcg ttggcccaat cacgccaaca      840

gttttatctt tgagaaagga gctctttaca gtgccttatc atgagataga ttggaataaa      900

gcacgcaatg agtgcgcaaa ggaagacctt tactacccgc accctctagt acaagatatc      960

ctgtgggctt cacttcacaa ggttgtggaa cctattctga tgcattggcc agggaaaaga     1020

ttgagagaaa aagctctccg catagtgatg gagcacattc attatgaaga tgaaaacact     1080

cgttacatat gcataggacc tgtaaacaag attttaaata tgctttgctg ctgggttgaa     1140

gatcctaatt cagaagcttt caagttgcac cttccaagaa ttcatgacta tatgtgggtt     1200

gctgaagatg gcatgaaaat taagggatac aatggaagtc aatcttggga tacttcattt     1260

gcaattcaag caatcattgc aacagagctt ggcgaggaat atggttcagc attgagaaaa     1320

gcgcattcat tcataaaaaa tacacaggtg ttagatgatt gcccaggcaa tctagatttc     1380

tggtaccgtc atatttcaaa aggtgcttgg cccttttcaa ctgcagatca cggatggccc     1440

atttcagatt gtactgcaga gggacttaaa gcaactcttc tattatcaaa actaccatca     1500

gagatagtcg gtgatccatt ggatgcaaag cgtttctatg atgctgtaaa tgttttgctt     1560

tctttacaga atagtggtgg tggctttgca acatatgaac tatcgaggtc atatccgtgg     1620

ttagagataa tcaatcctgc tgagactttt ggagatattg ttattgatta cccttatgta     1680

gagtgttcct cagctgcaat tcaagcttta acagcattta agaaattata ccctggtcat     1740

cgcaaagaag aagtggaacg ctgtattgct aaagctgctg ccttcattga aaagattcaa     1800

gaagcagatg gctcctggta tggctcttgg gcagtttgct tcacctatgg cacttggttt     1860

ggggtgcttg gcttactagc tgcaggaagg aactacacta attcttccag catccgtaag     1920

gcttgtgact ttttgttgtc caaacaaatc tcatctggtg gctgggggga gagttacctg     1980

tcttgtcaaa acaaggtgta tacaaatctt gaaggcaaca gatatcatgt tgtaaataca     2040

tcatgggcta tgctgactct aattgctgct ggacaggctg agagaaatcc cacaccatta     2100

caccatgcag caaaagcatt aataaatgct cagctagaaa atggagattt tcctcagcag     2160

gagatcagcg gggtcttcaa caggaattgc atgatatcct attctgcata taggaacatt     2220

ttcccaattt gggcactggg agaatatcgt tctcgtgtac tcaaggctaa gtaa           2274


<210>  23
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer TkLUP fw

<400>  23
aaagtcgact aaaaaaatgt ggaagctgaa aatagc                                 36


<210>  24
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer TkLUP bw

<400>  24
aaactcgaga tatattttga acaatacga                                         29


<210>  25
<211>  1107
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  25
atgaatccta aatcctctac acctaagatt ccaagaccca agaacgcatt tattctgttc       60

agacagcact accacaggat cttaatagac gaatggaccg ctcaaggtgt ggaaataccc      120

cataattcaa acatttctaa aattattggt acgaagtgga agggcttaca accggaagat      180

aaggcacact gggaaaatct agcggagaag gagaaactag aacataaaag gaagtatcct      240

gaatacaaat acaagccggt aagaaagtct aagaagaagc aactactttt gaaggaaatc      300

gagcaacagc agcagcaaca acagaaagaa cagcagcagc agaaacagtc acaaccgcaa      360

ttacaacagc cctttaacaa caatatagtt cttatgaaaa gagcacattc tctttcacca      420

tcttcctcgg tgtcaagctc gaacagctat cagttccaat tgaacaatga tcttaagagg      480

ttgcctattc cttctgttaa tacttctaac tatatggtct ccagatcttt aagtggacta      540

cctttgacgc atgataagac ggcaagagac ctaccacagc tgtcatctca actaaattct      600

attccatatt actcagctcc acacgaccct tcaacgagac atcattacct caacgtcgct      660

caagctcaac caagggctaa ctcgacccct caattgccct ttatttcatc cattatcaac      720

aacagcagtc aaacaccggt aactacaact accacatcca caacaactgc gacatcttct      780

cctgggaaat tctcctcttc tccgaactcc tctgtactgg agaacaacag attaaacagt      840

atcaacaatt caaatcaata tttacctccc cctctattac cttctctgca agattttcaa      900

ctggatcagt accagcagct aaagcagatg ggaccaactt atattgtcaa accactgtct      960

cacaccagga acaatctatt gtccacaact acccctacgc atcatcacat tcctcatata     1020

ccaaaccaaa acattcctct acatcaaatt ataaactcaa gcaacactga ggtcaccgct     1080

aaaactagcc tagtttctcc gaaatga                                         1107


<210>  26
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer rox1 fw

<400>  26
aaagcggccg catgaatcct aaatcctcta c                                      31


<210>  27
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer rox1 bw

<400>  27
aaagcggccg ctcatttcgg agaaactagg                                        30


<210>  28
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer pESC-Ura_NotI fw

<400>  28
aaagcggccg cccagctgca ttaatgaatc g                                      31


<210>  29
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer pESC-Ura_NotI bw

<400>  29
aaagcggccg cgaagttcct attctctaga aa                                     32


<210>  30
<211>  1520
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  30
ataacttcgt atagcataca ttatacgaag ttatattaag ggttctcgag agctcgtttt       60

atttaggttc tatcgaggag aaaaagcgac aagaagagat agaccatgga taaactgatt      120

atgttctaaa cactcctcag aagctcatcg aactgtcatc ctgcgtgaag attaaaatcc      180

aacttagaaa tttcgagctt acggagacaa tcatatggga gaagcaattg gaagatagaa      240

aaaaggtact cggtacataa atatatgtga ttctgggtag aagatcggtc tgcattggat      300

ggtggtaacg cattttttta cacacattac ttgcctcgag catcaaatgg tggttattcg      360

tggatctata tcacgtgatt tgcttaagaa ttgtcgttca tggtgacact tttagctttg      420

acatgattaa gctcatctca attgatgtta tctaaagtca tttcaactat ctaagatgtg      480

gttgtgattg ggccattttg tgaaagccag tacgccagcg tcaatacact cccgtcaatt      540

agttgcacca tgtccacaaa atcatatacc agtagagctg agactcatgc aagtccggtt      600

gcatcgaaac ttttacgttt aatggatgaa aagaagacca atttgtgtgc ttctcttgac      660

gttcgttcga ctgatgagct attgaaactt gttgaaacgt tgggtccata catttgcctt      720

ttgaaaacac acgttgatat cttggatgat ttcagttatg agggtactgt cgttccattg      780

aaagcattgg cagagaaata caagttcttg atatttgagg acagaaaatt cgccgatatc      840

ggtaacacag tcaaattaca atatacatcg ggcgtttacc gtatcgcaga atggtctgat      900

atcaccaacg cccacggggt tactggtgct ggtattgttg ctggcttgaa acaaggtgcg      960

caagaggtca ccaaagaacc aaggggatta ttgatgcttg ctgaattgtc ttccaagggt     1020

tctctagcac acggtgaata tactaagggt accgttgata ttgcaaagag tgataaagat     1080

ttcgttattg ggttcattgc tcagaacgat atgggaggaa gagaagaagg gtttgattgg     1140

ctaatcatga ccccaggtgt aggtttagac gacaaaggcg atgcattggg tcagcagtac     1200

agaaccgtcg acgaagttgt aagtggtgga tcagatatca tcattgttgg cagaggactt     1260

ttcgccaagg gtagagatcc taaggttgaa ggtgaaagat acagaaatgc tggatgggaa     1320

gcgtaccaaa agagaatcag cgctccccat taattataca ggaaacttaa tagaacaaat     1380

cacatattta atctaatagc cacctgcatt ggcacggtgc aacactactt caacttcatc     1440

ttacaaaaag atcacgtgat ctgttgtatt gggatctcta gacctaataa cttcgtatag     1500

catacattat acgaagttat                                                 1520


<210>  31
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  AsiSI/Nb.BsmI USER cassette

<400>  31
cgtgcgatcg cgtgca                                                       16


<210>  32
<211>  1509
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  32
atggttttaa ccaataaaac agtcatttct ggatcgaaag tcaaaagttt atcatctgcg       60

caatcgagct catcaggacc ttcatcatct agtgaggaag atgattcccg cgatattgaa      120

agcttggata agaaaatacg tcctttagaa gaattagaag cattattaag tagtggaaat      180

acaaaacaat tgaagaacaa agaggtcgct gccttggtta ttcacggtaa gttacctttg      240

tacgctttgg agaaaaaatt aggtgatact acgagagcgg ttgcggtacg taggaaggct      300

ctttcaattt tggcagaagc tcctgtatta gcatctgatc gtttaccata taaaaattat      360

gactacgacc gcgtatttgg cgcttgttgt gaaaatgtta taggttacat gcctttgccc      420

gttggtgtta taggcccctt ggttatcgat ggtacatctt atcatatacc aatggcaact      480

acagagggtt gtttggtagc ttctgccatg cgtggctgta aggcaatcaa tgctggcggt      540

ggtgcaacaa ctgttttaac taaggatggt atgacaagag gcccagtagt ccgtttccca      600

actttgaaaa gatctggtgc ctgtaagata tggttagact cagaagaggg acaaaacgca      660

attaaaaaag cttttaactc tacatcaaga tttgcacgtc tgcaacatat tcaaacttgt      720

ctagcaggag atttactctt catgagattt agaacaacta ctggtgacgc aatgggtatg      780

aatatgattt ctaaaggtgt cgaatactca ttaaagcaaa tggtagaaga gtatggctgg      840

gaagatatgg aggttgtctc cgtttctggt aactactgta ccgacaaaaa accagctgcc      900

atcaactgga tcgaaggtcg tggtaagagt gtcgtcgcag aagctactat tcctggtgat      960

gttgtcagaa aagtgttaaa aagtgatgtt tccgcattgg ttgagttgaa cattgctaag     1020

aatttggttg gatctgcaat ggctgggtct gttggtggat ttaacgcaca tgcagctaat     1080

ttagtgacag ctgttttctt ggcattagga caagatcctg cacaaaatgt tgaaagttcc     1140

aactgtataa cattgatgaa agaagtggac ggtgatttga gaatttccgt atccatgcca     1200

tccatcgaag taggtaccat cggtggtggt actgttctag aaccacaagg tgccatgttg     1260

gacttattag gtgtaagagg cccgcatgct accgctcctg gtaccaacgc acgtcaatta     1320

gcaagaatag ttgcctgtgc cgtcttggca ggtgaattat ccttatgtgc tgccctagca     1380

gccggccatt tggttcaaag tcatatgacc cacaacagga aacctgctga accaacaaaa     1440

cctaacaatt tggacgccac tgatataaat cgtttgaaag atgggtccgt cacctgcatt     1500

aaatcctaa                                                             1509


<210>  33
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer tHMGR fw

<400>  33
aaaggatcca aaaaaatggt tttaaccaat aaaac                                  35


<210>  34
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer tHMGR bw

<400>  34
aaagtcgact taggatttaa tgcaggtgac                                        30


<210>  35
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG13-fw

<400>  35
aaagaattca aaaaaatgaa actctcaact aaactttg                               38


<210>  36
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG13-bw

<400>  36
aaagcggccg cttatttttt aacatcgtaa gatc                                   34


<210>  37
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  expression cassette fw-primer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is uracil

<400>  37
cgtgcgantc agagcgacct catgctatac                                        30


<210>  38
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  expression cassette bw-primer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is uracil

<400>  38
cacgcganct tcgagcgtcc caaaacc                                           27


<210>  39
<211>  533
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  39
cacatttaag ggctatacaa agatgacaga attttattct gacacaatcg gtctaccaaa       60

gacagatcca cgtctttgga gactgagaac tgatgagcta ggccgagaaa gctgggaata      120

tttaacccct cagcaagccg caaacgaccc accatccact ttcacgcagt ggcttcttca      180

agatcccaaa tttcctcaac ctcatccaga aagaaataag cattcaccag atttttcagc      240

cttcgatgcg tgtcataatg gtgcatcttt tttcaaactg cttcaagagc ctgactcagg      300

tatttttccg tgtcaatata aaggacccat gttcatgaca atcggttacg tagccgtaaa      360

ctatatcgcc ggtattgaaa ttcctgagca tgagagaata gaattaatta gatacatcgt      420

caatacagca catccggttg atggtggctg gggtctacat tctgttgaca aatccaccgt      480

gtttggtaca gtattgaact atgtaatctt acgtttattg gggcggccgc ttt             533


<210>  40
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG7 fragment fw

<400>  40
cacatttaag ggctatacaa agatgacaga attttattct gaca                        44


<210>  41
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG7 fragment-bw

<400>  41
aaagcggccg ccccaataaa cgtaagatta ca                                     32


<210>  42
<211>  735
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  42
ggtattccaa tgagaatcgc tagaaatgct ttaccagaac tagactactt gtcgcagatc       60

acttttgaac tgtatgagag tacggatgct tctggtcaaa aatcgcattc cattagactg      120

aaaatgtctc ctgggtgtca tactcaagat ccgttagatg ttcaattaga tgacaggcat      180

tatattagtt gtattccaaa gatttccctg acgaagcatt tggatatgga ctacgttcaa      240

cagaaattga gaaacaaatt taccagggtc attatgcctc cgaaatttac accagtaaac      300

attacgagcc ccaacttgag tttccagaaa cgcaaaacca gaagaaagtc ggtatctgtt      360

gagaagttga agcttcctgc ctcgtccgga tcttcatcat ctacctccgt taacaagaca      420

ttagattagt gatcacaccc aatttttaat ttagcaaccc aaaataaata agtatttact      480

caactttttt ttaataaaaa aaaacttaat tgaattttgc tcgcgatctt taggtccggg      540

gttttcgttg aacccttaga cgagcaaatt agcgccataa ggatatacgt cagagcacat      600

taattagtga catataccta tataaagagc aaccttctcc gatagacttg taatttatct      660

tatttcattt cctaacactt tggtcgaaga agagggataa gaacagacga aaacacattt      720

aagggctata caaag                                                       735


<210>  43
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  ologonucleotide primer CTR promoter fragment-fw

<400>  43
aaagcggccg ccagctgaag gatccggtat tccaatgaga atcgc                       45


<210>  44
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer CTR promoter fragment-bw

<400>  44
tgtcagaata aaattctgtc atctttgtat agcccttaaa tgt                         43


<210>  45
<211>  510
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  45
aatctgctgc tattcgtgat tactgttaca acctaacggt ttaaatgaaa cctggttctg       60

aagggtcatt ttataacttc aagttccctt agcctttcga ttcattttga ttatgccatt      120

tctagaccgt gttataggcg ctggcgttta atttggtgta gcttggttta gtcaagagtt      180

gtattagtgt tcctcgataa agtcgatgtt tccggatatt gtgttaaaat ttcaagtatg      240

ctactaatgg ggtaaagttg catgattagc agagacatat ggcttgttat ggttcggctt      300

cctcattttt catgcttagt ttttgtccat ctcattgtac atttctgaat cctaatgcat      360

gactccctaa cattactatt aaattctcaa tagtgaagaa taagcaaaat gggaaccatg      420

ataatttcta gctttctctc cacccctatt ttaatttgca atcatatata gtactttcaa      480

tagcatcttt tctagatttg atatctgcgg                                       510


<210>  46
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG7 promoter fragment-fw

<400>  46
aaacagctga atctgctgct attcgtg                                           27


<210>  47
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer ERG7 promoter fragment-bw

<400>  47
aaaggatccc ctgcaggcgc tgcaggtcga caac                                   34


<210>  48
<211>  2519
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  48
aaacctgcag gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt       60

gagcgcgcgt aatacgactc actatagggc gaattgggtg cataggccac tagtggatct      120

gatatcacct aataacttcg tatagcatac attatacgaa gttatattaa gggttctcga      180

gagctcgctg tgaagatccc agcaaaggct tacaaagtgt tatctctttt gagacttgtt      240

gagttgaaca ctggtgtttt catcaaactt accaaggacg tgtacccatt gttgaaactt      300

gtatcaccat atattgttat cggacaacct tcacttgcat ctatccgttc tttaatccaa      360

aagagatcta gaataatgtg gcaaaggcca gaagataaag aaccaaaaga gataatcttg      420

aatgacaaca atatcgttga agagaaatta ggtgatgaag gtgtcatttg tatcgaggat      480

atcatccatg agatttcgac gttgggcgaa aatttctcga aatgtacttt cttcctatta      540

ccattcaaat tgaacagaga agtcagtgga ttcggtgcca tctcccgttt gaataaactg      600

aaaatgcgcg aacaaaacaa gaagactcgt caaatttcaa acgctgccac ggctccagtt      660

atccaagtag atatcgactc aatgatttcc aagttgaatt gattaactat aaaaggaaaa      720

tatctgtaca atagacatcg ggctcccatt ggccctaccc acatatgtag aaatacatta      780

ctctattcac tactgcattt agttatgttt aacatttgat atagcagact accgccaggc      840

acaatatatt ccccttccct cttgccattc gctgtacttg tggtggattc caattcagcg      900

cagtcacgtg ctagtaatca ccgcattttt ttcttttcct ttcaggctaa aaccggttcc      960

gggcctgatc cctgcactca ttttctaacg gaaaaccttc agaagcataa ctacccattc     1020

cagtttagag tcatgacagg ttcaacatca gatgcttcat atacttttat atattgaatt     1080

atataaatat atctatgtac tctaagtaag tacatctgct ttaacgcatt cctacatttg     1140

cttcgattta tttttattgt tgatacctat ttgaagaagt aaaaagtatc ccacactaca     1200

cagattatac catgtctaag aatatcgttg tcctaccggg tgatcacgtc ggtaaagaag     1260

ttactgacga agctattaag gtcttgaatg ccattgctga agtccgtcca gaaattaagt     1320

tcaatttcca acatcacttg atcgggggtg ctgccatcga tgccactggc actcctttac     1380

cagatgaagc tctagaagcc tctaagaaag ccgatgctgt cttactaggt gctgttggtg     1440

gtccaaaatg gggtacgggc gcagttagac cagaacaagg tctattgaag atcagaaagg     1500

aattgggtct atacgccaac ttgagaccat gtaactttgc ttctgattct ttactagatc     1560

tttctccttt gaagcctgaa tatgcaaagg gtaccgattt cgtcgtcgtt agagaattgg     1620

ttggtggtat ctactttggt gaaagaaaag aagatgaagg tgacggagtt gcttgggact     1680

ctgagaaata cagtgttcct gaagttcaaa gaattacaag aatggctgct ttcttggcat     1740

tgcaacaaaa cccaccatta ccaatctggt ctcttgacaa ggctaacgtg cttgcctctt     1800

ccagattgtg gagaaagact gttgaagaaa ccatcaagac tgagttccca caattaactg     1860

ttcagcacca attgatcgac tctgctgcta tgattttggt taaatcacca actaagctaa     1920

acggtgttgt tattaccaac aacatgtttg gtgatattat ctccgatgaa gcctctgtta     1980

ttccaggttc tttgggttta ttaccttctg catctctagc ttccctacct gacactaaca     2040

aggcattcgg tttgtacgaa ccatgtcatg gttctgcccc agatttacca gcaaacaagg     2100

ttaacccaat tgctaccatc ttatctgcag ctatgatgtt gaagttatcc ttggatttgg     2160

ttgaagaagg tagggctctt gaagaagctg ttagaaatgt cttggatgca ggtgtcagaa     2220

ccggtgacct tggtggttct aactctacca ctgaggttgg cgatgctatc gccaaggctg     2280

tcaaggaaat cttggcttaa agagtctttt gtaacgaccc cgtctccacc aacttggtat     2340

gcttgaaatc tcaaggccat tacacattca gttatgtgaa cgaaaggtct ttatttaacg     2400

tagcataaac taaataatac aggttccggt tagcctgcgg atctctagac ctaataactt     2460

cgtatagcat acattatacg aagttatatt aagggttgtc gacctgcagc ggatccaaa      2519


<210>  49
<211>  1335
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  49
atgggaaagc tattacaatt ggcattgcat ccggtcgaga tgaaggcagc tttgaagctg       60

aagttttgca gaacaccgct attctccatc tatgatcagt ccacgtctcc atatctcttg      120

cactgtttcg aactgttgaa cttgacctcc agatcgtttg ctgctgtgat cagagagctg      180

catccagaat tgagaaactg tgttactctc ttttatttga ttttaagggc tttggatacc      240

atcgaagacg atatgtccat cgaacacgat ttgaaaattg acttgttgcg tcacttccac      300

gagaaattgt tgttaactaa atggagtttc gacggaaatg cccccgatgt gaaggacaga      360

gccgttttga cagatttcga atcgattctt attgaattcc acaaattgaa accagaatat      420

caagaagtca tcaaggagat caccgagaaa atgggtaatg gtatggccga ctacatcttg      480

gatgaaaatt acaacttgaa tgggttgcaa accgtccacg actacgacgt gtactgtcac      540

tacgtagctg gtttggtcgg tgatggtttg acccgtttga ttgtcattgc caagtttgcc      600

aacgaatctt tgtattctaa tgagcaattg tatgaaagca tgggtctttt cctacaaaaa      660

accaacatca tcagagacta caatgaagat ttggtcgatg gtagatcctt ctggcccaag      720

gaaatctggt cacaatacgc tcctcagttg aaggacttca tgaaacctga aaacgaacaa      780

ctggggttgg actgtataaa ccacctcgtc ttaaacgcat tgagtcatgt tatcgatgtg      840

ttgacttatt tggccagtat ccacgagcaa tccactttcc aattttgtgc cattccccaa      900

gttatggcca ttgcaacctt ggctttggta ttcaacaacc gtgaagtgct acatggcaat      960

gtaaagattc gtaagggtac tacctgctat ttaattttga aatcaaggac tttgcgtggc     1020

tgtgtcgaga tttttgacta ttacttacgt gatatcaaat ctaaattggc tgtgcaagat     1080

ccaaatttct taaaattgaa cattcaaatc tccaagatcg aacaattcat ggaagaaatg     1140

taccaggata aattacctcc taacgtgaag ccaaatgaaa ctccaatttt cttgaaagtt     1200

aaagaaagat ccagatacga tgatgaattg gtcccaaccc aacaagaaga agagtacaag     1260

ttcaatatgg ttttatctat catcttgtcc gttcttcttg ggttttatta tatatacact     1320

ttacacagag cgtga                                                      1335


<210>  50
<211>  493
<212>  DNA
<213>  unknown

<220>
<223>  MET3 promoter

<400>  50
tttagtacta acagagactt ttgtcacaac tacatataag tgtacaaata tagtacagat       60

atgacacact tgtagcgcca acgcgcatcc tacggattgc tgacagaaaa aaaggtcacg      120

tgaccagaaa agtcacgtgt aattttgtaa ctcaccgcat tctagcggtc cctgtcgtgc      180

acactgcact caacaccata aaccttagca acctccaaag gaaatcaccg tataacaaag      240

ccacagtttt acaacttagt ctcttatgaa gttacttacc aatgagaaat agaggctctt      300

tctcgagaaa tatgaatatg gatatatata tatatatata tatatatata tatatatatg      360

taaacttggt tcttttttag cttgtgatct ctagcttggg tctctctctg tcgtaacagt      420

tgtgatatcg tttcttaaca attgaaaagg aactaagaaa gtataataat aacaagaata      480

aagtataatt aac                                                         493


<210>  51
<211>  1491
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  51
atgtctgctg ttaacgttgc acctgaattg attaatgccg acaacacaat tacctacgat       60

gcgattgtca tcggtgctgg tgttatcggt ccatgtgttg ctactggtct agcaagaaag      120

ggtaagaaag ttcttatcgt agaacgtgac tgggctatgc ctgatagaat tgttggtgaa      180

ttgatgcaac caggtggtgt tagagcattg agaagtctgg gtatgattca atctatcaac      240

aacatcgaag catatcctgt taccggttat accgtctttt tcaacggcga acaagttgat      300

attccatacc cttacaaggc cgatatccct aaagttgaaa aattgaagga cttggtcaaa      360

gatggtaatg acaaggtctt ggaagacagc actattcaca tcaaggatta cgaagatgat      420

gaaagagaaa ggggtgttgc ttttgttcat ggtagattct tgaacaactt gagaaacatt      480

actgctcaag agccaaatgt tactagagtg caaggtaact gtattgagat attgaaggat      540

gaaaagaatg aggttgttgg tgccaaggtt gacattgatg gccgtggcaa ggtggaattc      600

aaagcccact tgacatttat ctgtgacggt atcttttcac gtttcagaaa ggaattgcac      660

ccagaccatg ttccaactgt cggttcttcg tttgtcggta tgtctttgtt caatgctaag      720

aatcctgctc ctatgcacgg tcacgttatt cttggtagtg atcatatgcc aatcttggtt      780

taccaaatca gtccagaaga aacaagaatc ctttgtgctt acaactctcc aaaggtccca      840

gctgatatca agagttggat gattaaggat gtccaacctt tcattccaaa gagtctacgt      900

ccttcatttg atgaagccgt cagccaaggt aaatttagag ctatgccaaa ctcctacttg      960

ccagctagac aaaacgacgt cactggtatg tgtgttatcg gtgacgctct aaatatgaga     1020

catccattga ctggtggtgg tatgactgtc ggtttgcatg atgttgtctt gttgattaag     1080

aaaataggtg acctagactt cagcgaccgt gaaaaggttt tggatgaatt actagactac     1140

catttcgaaa gaaagagtta cgattccgtt attaacgttt tgtcagtggc tttgtattct     1200

ttgttcgctg ctgacagcga taacttgaag gcattacaaa aaggttgttt caaatatttc     1260

caaagaggtg gcgattgtgt caacaaaccc gttgaatttc tgtctggtgt cttgccaaag     1320

cctttgcaat tgaccagggt tttcttcgct gtcgcttttt acaccattta cttgaacatg     1380

gaagaacgtg gtttcttggg attaccaatg gctttattgg aaggtattat gattttgatc     1440

acagctatta gagtattcac cccatttttg tttggtgagt tgattggtta a              1491


<210>  52
<211>  496
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  52

Met Ser Ala Val Asn Val Ala Pro Glu Leu Ile Asn Ala Asp Asn Thr 
1               5                   10                  15      


Ile Thr Tyr Asp Ala Ile Val Ile Gly Ala Gly Val Ile Gly Pro Cys 
            20                  25                  30          


Val Ala Thr Gly Leu Ala Arg Lys Gly Lys Lys Val Leu Ile Val Glu 
        35                  40                  45              


Arg Asp Trp Ala Met Pro Asp Arg Ile Val Gly Glu Leu Met Gln Pro 
    50                  55                  60                  


Gly Gly Val Arg Ala Leu Arg Ser Leu Gly Met Ile Gln Ser Ile Asn 
65                  70                  75                  80  


Asn Ile Glu Ala Tyr Pro Val Thr Gly Tyr Thr Val Phe Phe Asn Gly 
                85                  90                  95      


Glu Gln Val Asp Ile Pro Tyr Pro Tyr Lys Ala Asp Ile Pro Lys Val 
            100                 105                 110         


Glu Lys Leu Lys Asp Leu Val Lys Asp Gly Asn Asp Lys Val Leu Glu 
        115                 120                 125             


Asp Ser Thr Ile His Ile Lys Asp Tyr Glu Asp Asp Glu Arg Glu Arg 
    130                 135                 140                 


Gly Val Ala Phe Val His Gly Arg Phe Leu Asn Asn Leu Arg Asn Ile 
145                 150                 155                 160 


Thr Ala Gln Glu Pro Asn Val Thr Arg Val Gln Gly Asn Cys Ile Glu 
                165                 170                 175     


Ile Leu Lys Asp Glu Lys Asn Glu Val Val Gly Ala Lys Val Asp Ile 
            180                 185                 190         


Asp Gly Arg Gly Lys Val Glu Phe Lys Ala His Leu Thr Phe Ile Cys 
        195                 200                 205             


Asp Gly Ile Phe Ser Arg Phe Arg Lys Glu Leu His Pro Asp His Val 
    210                 215                 220                 


Pro Thr Val Gly Ser Ser Phe Val Gly Met Ser Leu Phe Asn Ala Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Met His Gly His Val Ile Leu Gly Ser Asp His Met 
                245                 250                 255     


Pro Ile Leu Val Tyr Gln Ile Ser Pro Glu Glu Thr Arg Ile Leu Cys 
            260                 265                 270         


Ala Tyr Asn Ser Pro Lys Val Pro Ala Asp Ile Lys Ser Trp Met Ile 
        275                 280                 285             


Lys Asp Val Gln Pro Phe Ile Pro Lys Ser Leu Arg Pro Ser Phe Asp 
    290                 295                 300                 


Glu Ala Val Ser Gln Gly Lys Phe Arg Ala Met Pro Asn Ser Tyr Leu 
305                 310                 315                 320 


Pro Ala Arg Gln Asn Asp Val Thr Gly Met Cys Val Ile Gly Asp Ala 
                325                 330                 335     


Leu Asn Met Arg His Pro Leu Thr Gly Gly Gly Met Thr Val Gly Leu 
            340                 345                 350         


His Asp Val Val Leu Leu Ile Lys Lys Ile Gly Asp Leu Asp Phe Ser 
        355                 360                 365             


Asp Arg Glu Lys Val Leu Asp Glu Leu Leu Asp Tyr His Phe Glu Arg 
    370                 375                 380                 


Lys Ser Tyr Asp Ser Val Ile Asn Val Leu Ser Val Ala Leu Tyr Ser 
385                 390                 395                 400 


Leu Phe Ala Ala Asp Ser Asp Asn Leu Lys Ala Leu Gln Lys Gly Cys 
                405                 410                 415     


Phe Lys Tyr Phe Gln Arg Gly Gly Asp Cys Val Asn Lys Pro Val Glu 
            420                 425                 430         


Phe Leu Ser Gly Val Leu Pro Lys Pro Leu Gln Leu Thr Arg Val Phe 
        435                 440                 445             


Phe Ala Val Ala Phe Tyr Thr Ile Tyr Leu Asn Met Glu Glu Arg Gly 
    450                 455                 460                 


Phe Leu Gly Leu Pro Met Ala Leu Leu Glu Gly Ile Met Ile Leu Ile 
465                 470                 475                 480 


Thr Ala Ile Arg Val Phe Thr Pro Phe Leu Phe Gly Glu Leu Ile Gly 
                485                 490                 495     


<210>  53
<211>  444
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  53

Met Gly Lys Leu Leu Gln Leu Ala Leu His Pro Val Glu Met Lys Ala 
1               5                   10                  15      


Ala Leu Lys Leu Lys Phe Cys Arg Thr Pro Leu Phe Ser Ile Tyr Asp 
            20                  25                  30          


Gln Ser Thr Ser Pro Tyr Leu Leu His Cys Phe Glu Leu Leu Asn Leu 
        35                  40                  45              


Thr Ser Arg Ser Phe Ala Ala Val Ile Arg Glu Leu His Pro Glu Leu 
    50                  55                  60                  


Arg Asn Cys Val Thr Leu Phe Tyr Leu Ile Leu Arg Ala Leu Asp Thr 
65                  70                  75                  80  


Ile Glu Asp Asp Met Ser Ile Glu His Asp Leu Lys Ile Asp Leu Leu 
                85                  90                  95      


Arg His Phe His Glu Lys Leu Leu Leu Thr Lys Trp Ser Phe Asp Gly 
            100                 105                 110         


Asn Ala Pro Asp Val Lys Asp Arg Ala Val Leu Thr Asp Phe Glu Ser 
        115                 120                 125             


Ile Leu Ile Glu Phe His Lys Leu Lys Pro Glu Tyr Gln Glu Val Ile 
    130                 135                 140                 


Lys Glu Ile Thr Glu Lys Met Gly Asn Gly Met Ala Asp Tyr Ile Leu 
145                 150                 155                 160 


Asp Glu Asn Tyr Asn Leu Asn Gly Leu Gln Thr Val His Asp Tyr Asp 
                165                 170                 175     


Val Tyr Cys His Tyr Val Ala Gly Leu Val Gly Asp Gly Leu Thr Arg 
            180                 185                 190         


Leu Ile Val Ile Ala Lys Phe Ala Asn Glu Ser Leu Tyr Ser Asn Glu 
        195                 200                 205             


Gln Leu Tyr Glu Ser Met Gly Leu Phe Leu Gln Lys Thr Asn Ile Ile 
    210                 215                 220                 


Arg Asp Tyr Asn Glu Asp Leu Val Asp Gly Arg Ser Phe Trp Pro Lys 
225                 230                 235                 240 


Glu Ile Trp Ser Gln Tyr Ala Pro Gln Leu Lys Asp Phe Met Lys Pro 
                245                 250                 255     


Glu Asn Glu Gln Leu Gly Leu Asp Cys Ile Asn His Leu Val Leu Asn 
            260                 265                 270         


Ala Leu Ser His Val Ile Asp Val Leu Thr Tyr Leu Ala Ser Ile His 
        275                 280                 285             


Glu Gln Ser Thr Phe Gln Phe Cys Ala Ile Pro Gln Val Met Ala Ile 
    290                 295                 300                 


Ala Thr Leu Ala Leu Val Phe Asn Asn Arg Glu Val Leu His Gly Asn 
305                 310                 315                 320 


Val Lys Ile Arg Lys Gly Thr Thr Cys Tyr Leu Ile Leu Lys Ser Arg 
                325                 330                 335     


Thr Leu Arg Gly Cys Val Glu Ile Phe Asp Tyr Tyr Leu Arg Asp Ile 
            340                 345                 350         


Lys Ser Lys Leu Ala Val Gln Asp Pro Asn Phe Leu Lys Leu Asn Ile 
        355                 360                 365             


Gln Ile Ser Lys Ile Glu Gln Phe Met Glu Glu Met Tyr Gln Asp Lys 
    370                 375                 380                 


Leu Pro Pro Asn Val Lys Pro Asn Glu Thr Pro Ile Phe Leu Lys Val 
385                 390                 395                 400 


Lys Glu Arg Ser Arg Tyr Asp Asp Glu Leu Val Pro Thr Gln Gln Glu 
                405                 410                 415     


Glu Glu Tyr Lys Phe Asn Met Val Leu Ser Ile Ile Leu Ser Val Leu 
            420                 425                 430         


Leu Gly Phe Tyr Tyr Ile Tyr Thr Leu His Arg Ala 
        435                 440                 


<210>  54
<211>  1008
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  54
atggaggcca agatagatga gctgatcaat aatgatcctg tttggtccag ccaaaatgaa       60

agcttgattt caaaacctta taatcacatc cttttgaaac ctggcaagaa ctttagacta      120

aatttaatag ttcaaattaa cagagttatg aatttgccca aagaccagct ggccatagtt      180

tcgcaaattg ttgagctctt gcataattcc agccttttaa tcgacgatat agaagataat      240

gctcccttga gaaggggaca gaccacttct cacttaatct tcggtgtacc ctccactata      300

aacaccgcaa attatatgta tttcagagcc atgcaacttg tatcgcagct aaccacaaaa      360

gagcctttgt atcataattt gattacgatt ttcaacgaag aattgatcaa tctacatagg      420

ggacaaggct tggatatata ctggagagac tttctgcctg aaatcatacc tactcaggag      480

atgtatttga atatggttat gaataaaaca ggcggccttt tcagattaac gttgagactc      540

atggaagcgc tgtctccttc ctcacaccac ggccattcgt tggttccttt cataaatctt      600

ctgggtatta tttatcagat tagagatgat tacttgaatt tgaaagattt ccaaatgtcc      660

agcgaaaaag gctttgctga ggacattaca gaggggaagt tatcttttcc catcgtccac      720

gcccttaact tcactaaaac gaaaggtcaa actgagcaac acaatgaaat tctaagaatt      780

ctcctgttga ggacaagtga taaagatata aaactaaagc tgattcaaat actggaattc      840

gacaccaatt cattggccta caccaaaaat tttattaatc aattagtgaa tatgataaaa      900

aatgataatg aaaataagta tttacctgat ttggcttcgc attccgacac cgccaccaat      960

ttacatgacg aattgttata tataatagac cacttatccg aattgtga                  1008


<210>  55
<211>  405
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  55
atgatagaat tggattatgt aaaaggtgaa gataccattg tagaagcaac cagcacgtcg       60

ccgtggctga tgaggtctcc tcttgcccgg gccgcagaaa agaggggcag tggcctgttt      120

ttcgacataa atgaggggca tggccagcac cgagacgtca ttgttgcata tggcgtatcc      180

aagccgaaac ggcgctcgcc tcatccccac gggaataagg cagccgacaa aagaaaaacg      240

accgaaaagg aaccagaaag aaaaaagagg gtgggcgcgc cgcggacgtg taaaaagata      300

tgcatccagc ttctatatcg ctttaacttt accgttttgg gcatcgggaa cgtatgtaac      360

attgatctcc tcttgggaac ggtgagtgca acgaatgcga tatag                      405


<210>  56
<211>  957
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  56
atggaattct tttatgaaga gcaagtagct tgtatcgaag atgataaaat aaacgactct       60

cataccaagg aaactggatc aacagaaaac actgaaaata acgaacttca gagccgagat      120

gacaaaacaa atggggcctt ccaaaagtta gaagaggaag tcaataaacg atatgaaaag      180

actacaagtg cattcaaaaa gttagtaatc gaaaaagatg acggaattga gattaacttg      240

ccaattagca atgaaactac agagactgca caaaagtatt tgaagaaact agacgagaac      300

attcacagcg tggaaagtct agcccagtca tattggagca aaatgaaaac taagaatttt      360

tggtctggct tcagtagctt cgataatgct gcagaaaatg actctaatga caaggatgag      420

aattcgaaag aaaatgaaat tgctgtgggt ggaaatagaa cagaagccga actaaggaca      480

ttatctaaag ataaatcggt ttatttagac aataaaatgg atttgcaact ggacccgttt      540

gacgtggatg aaaaaactga ggagatatgt tctattttac agggcgacaa agatatctcc      600

aaattaatga acgacatcgt accccataaa atcagctata aagatttctg gcacatctat      660

ttcttacaaa gaaacaaaat tctagataaa gaaagtaaaa ggaaagaaat attgtccaaa      720

aaggaaaagg aaacggagga aaaagaagtt gagtgggatg acgaagaaga agatgatgat      780

gatgacaaag tagaagcagt agttgacaac aaatctaaag gagagacgaa agttgctgtg      840

tctcaagagg gattgaaaga tgttagtgac catgttggcc tcgccaacaa ggatgagagc      900

aaggacgacg acgacgacga cgacgacgac gacgacgacg atgatgactg ggaatga         957


<210>  57
<211>  537
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  57
atgactggat accctgacgt ggccgccttc gatttggact acaccatttg gccctgctat       60

tgtgataccc atttgcacgg tccctttaag ccagttaaaa gtagtaatgg cgaagttctc      120

acaattatat gtagagatgg ttacgagctc acaatctaca aagatatccc acgtatacta      180

ggtgatctta aagataatgg agttaagtta atgaccgcgt cacgaacgtg ggcacctgag      240

attgcccagg aaatactgaa aatattcaag gtcaagtatg ctggtgtcgt aaccccgttg      300

gccaacctgt tcgatgaatt tcagtgggga gaaagaagta aaattggcca tttaagggac      360

ggtttgaaag atctttataa taccagcgat ttaaaatcga aaaagatttg tttatttgat      420

gatgaaagta gaaacaaaga agtggagaaa tacggagtga agtttgttta tgtaagagac      480

ccagagaatg gaccatcttg gaaactttat caagattacc tgagtggaaa ggtttga         537


<210>  58
<211>  1749
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  58
atggaggaaa ctaagtactc ttcgcagcag gagatagaag gagcatgtgg ttcagacgct       60

tcattgaatg ctagaggtag caatgattct ccaatgggac tttccttgta cctctgcctg      120

gcttcgttaa ctcttgtact attcataact gcactggata ttttgatagt gggaactatt      180

attgacgtgg tcgcagaaca gttcggaaac tactccaaaa caggttggct cgttacaggc      240

tacagtttac caaatgctat tctgagtctc atttggggaa gattcgcatc tatcataggt      300

ttccagcata gtctcatttt agcaatactt atttttgaag ccggatccct aattgctgcc      360

cttgcctctt caatgaatat gctcattttc ggtagagttg ttgctggtgt tgggggaagc      420

ggactccaaa cgctttgctt tgttattggt tgtacgatgg ttggtgaaag gtcacgtcca      480

ttggtgattt ccatcctaag ttgtgcattt gctgtagctg ctatcgttgg tcctataatc      540

ggaggtgcct ttacaaccca tgttacctgg aggtggtgct tctatatcaa tcttcctatc      600

ggtggtcttg ccattattat gtttttactc acatataagg ccgagaataa gggtatactt      660

caacaaatta aagatgctat aggaacaatc tcgagcttta cttttagtaa gttcagacac      720

caagttaatt ttaaaagact tatgaatggc ataatcttca agtttgactt ctttggtttt      780

gccctctgct ctgcagggct ggtccttttc ctactggggc taacctttgg tggtaataaa      840

tatagttgga actctggcca agtcatcgca tatttggttt tgggtgtctt actttttatt      900

ttttcattgg tgtacgattt cttcctattc gataaattca acccggaacc tgataatata      960

tcctacaggc ctctccttct aagaagattg gtagcaaaac cagccataat aatagtaaac     1020

atggtaacat ttctattatg taccggttac aatgggcaaa tgatatactc tgtccagttt     1080

ttccaactta tatttgcgtc gagtgcatgg aaagccggtc ttcacttgat accaatcgtt     1140

attaccaacg ttattgcggc cattgcaagt ggtgtgatta ccaaaaagct cggtttagtt     1200

aaaccactct taatatttgg aggcgttctt ggggtaattg gagcagggct tatgacactt     1260

atgacaaata cgtccacgaa gtcaactcaa attggtgttt tgctattacc ggggttttcc     1320

cttggatttg ctctacaagc atcgctcatg agtgcacagc ttcaaattac caaagatcgt     1380

ccagaagctg ctatggactt tattgaagta acagctttca atacattcat gaagtcatta     1440

ggtacaactc ttggtggtgt gctttcaacc actgtttttt ccgcctcctt tcacaacaaa     1500

gtatcacgag ctcatctaga gccttacgaa ggaaaaacgg ttgatgacat gattttgtat     1560

cgtcttcaaa actacgacgg ttctcattcg actattggaa acattttaag cgactccatt     1620

aagaacgtat tttggatgga tctagggttt tatgccttag gatttttgtt ttgtagtttt     1680

tcatccaata agaaattaat cataccaaaa aaggacgata caccagaaga taatttagaa     1740

gacaagtag                                                             1749


<210>  59
<211>  1824
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  59
atggacaggc ctaaggacgc tagaaagaga tctattagtt tggcctgtac tgtgtgtagg       60

aaacgaaagt tgaagtgcga tgggaacaag ccatgtggaa gatgtataag gctaaataca      120

ccaaaagaat gcatttatga tattgataaa aggaaagaca agagaaaaat caaaaacggg      180

tcgaaggttt ttttattcaa gaataatact atcgataacg ggaataactc tatactagag      240

aacaaaggac taaatgaaga cctttcttcc catatatatg agaaagaagc gccaaaattt      300

gattcagata ttgatatatc aagatttggc acaaatgatg ctgtgatttt taataatgac      360

gggtgggaca cttctcttcc gatcgatttt gatttcgatg agtttaacac tgagacaaca      420

gatttcgatg actttttaaa actattaggc gataattcac cttcaaagga acaaaaaagt      480

ctttcctatt ccccaactgc cataggctta agcggtgtgg ttaaagaaac tgagagcgaa      540

gataacgctc ctacgaggtc tcggctaatc gatgtcttgt ttgagaacga gcttcactcc      600

gtaccaggaa tatcaaaatg gcatctatat gagctggaat cccaataccc aaatttggaa      660

tgtacagaag gaaatagtga tgaaaagttt ttactttcaa ctgtattgtg cctggggtcg      720

ttgaccatac gaaaaaggga attattgaat cattcgaaca tagacaatag tccacttttg      780

ccagagaata gtatttcaaa actgaccgct gatgctttta agtactataa tgctgcgaaa      840

acgcttgttc ccgacttgtt atctcatccc acaatcgatg gattttgcgg cctcgttcta      900

atggcaaatt tcatgacgat gatgatatcc ttagagcacc aattatattt gagtataaat      960

gctttacaac ttgctgtggc tttaaacttg aacgacaata caaaatgcaa ggaattactt     1020

gagtcgaaca gcgacggaat tggtgtgatc ttgctttttt ggaacatttg gtgttcttct     1080

tgcatgttgg caacaattca tggaaaaaat ccttttatca ctttggaaca aattacaaca     1140

cctctgccgt gtgaaatatc cccccgcaat aaaaccaata aacttttgat agatttcatg     1200

caaatcagaa tcaagctagc cactctacaa agtaagattt ttcaacggct atatacttcc     1260

agcaccgcaa acgaggtacc attcgtaaac ttagaaagag aatttgagga agtttcactc     1320

cagattacca ggttaaaagg ctttccgata ttcgaagaac atctttttta caggagcaga     1380

gtcttaatgt tagagctatc atgtttaaga gctcaagctt cttttctatt atatcgtccg     1440

tatctgatca ctggagaatc cttacaagca gtaaccatgg caaaatcaat aattcacgaa     1500

atatggagtc aatacactaa acagtttccc gataacgaaa aggaaaggca tgaacgtttg     1560

gattggaatt tttgttatcc tttaagaaca gcgtcactga cattatgtat ttcatgtatt     1620

atactcctaa ggtataagca ggtggtgcag ttccttaaag gtactgaact atttgaatac     1680

attctagcat tggaaatatt gcaagattta gttcaggtac ttcctattga acaaaacctt     1740

attgatataa tcaaatatcc gatcagtcca gtacagctga gtggtgatag ctttgtcgaa     1800

ttttggggtc gcatacttta ctaa                                            1824


<210>  60
<211>  396
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  60
atgacacttg tagtatatct aactcggttt tcttccacta gaagcctcaa attctttgtt       60

gttggtatca catcattcaa aaactgcaga tggccgtcag aagagtgcac aattgcggca      120

gagatgtcat cgtacgacag cgtgagttca tctgggagcg gcggtacctg ttgttgttgc      180

tgctgctgtt gcctatgtag ggactcatgt gtcagcacct ggacgaagaa ttctgtagca      240

aacgctgtgg ctacgaatgc gtcatccgaa gtgtccatat attctggatc attcttggct      300

attctctgca ctttttctac aggtaacttg ggcgaacaca gaggtgcaga cgccgtttct      360

ttaccactag tctcgttgtt cattgtgtta gcctga                                396


<210>  61
<211>  441
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  61
atggggtcga aaagaacata cgtcgcgaaa aaaactgtga cacatgtgtt atattgcgtt       60

cctacaaggt ggatatcctt ggatagacct gcaacttctg cgttaccaat attcgattta      120

tccaggttag aaaggaaata tagcatcccc ataagaggaa tcaagtatat atccattttg      180

cgcaagacac gcttttccat tggatgggaa ggggagggga tgccgtcatc atccgtggta      240

gtagccataa tttcccgttc ggtggcaagt tccgacttct tgtcatggct gcgattatgc      300

aagctagcgt catggccttc atcttcctgg aacgtgactt ccgtaggctt ttcttctgat      360

ccatcattgg tgggtgatat gaaaagcaca tcatccacca aatgcttagg tgactccatt      420

gtaaatttgt tgctcatcta g                                                441


<210>  62
<211>  728
<212>  PRT
<213>  Pichia stipitis

<400>  62

Met Tyr Tyr Ser Asp Lys Leu Gly Ile Pro Lys Thr Asp Pro Ser Leu 
1               5                   10                  15      


Trp Arg Leu Arg Thr Thr Glu Leu Gly Arg Glu Thr Trp His Tyr Leu 
            20                  25                  30          


Thr Pro Gln Glu Ala Glu His Glu Pro Gln Thr Ser Tyr Val Lys Tyr 
        35                  40                  45              


Leu Leu Gln Thr Lys Asp Phe Gln Ala Pro Ala Glu Glu Lys Ile Thr 
    50                  55                  60                  


Ser Pro Phe His Ala Ala Glu Lys Gly Ala Gln Phe Leu Glu Leu Leu 
65                  70                  75                  80  


Gln Asp Glu Ser Gly Ile Phe Pro Cys Gln Tyr Lys Gly Pro Met Phe 
                85                  90                  95      


Met Thr Ile Gly Tyr Val Val Ala Asn Tyr Tyr Ser Gly Asn Glu Ile 
            100                 105                 110         


Pro Glu Pro Tyr Arg His Glu Met Ile Arg Tyr Ile Val Asn Ser Ala 
        115                 120                 125             


His Pro Val Asp Gly Gly Trp Gly Leu His Ser Ile Asp Lys Ser Thr 
    130                 135                 140                 


Cys Phe Gly Thr Ala Ile Asn Tyr Ile Val Leu Arg Leu Leu Gly Leu 
145                 150                 155                 160 


Glu Ala Asp His Pro Val Cys Ala Lys Ala Arg Lys Thr Leu His Ser 
                165                 170                 175     


Leu Gly Gly Ala Ile Lys Val Pro His Trp Gly Lys Ala Trp Leu Ser 
            180                 185                 190         


Ile Leu Ser Leu Tyr Glu Trp Glu Gly Val Asn Pro Ala Pro Pro Glu 
        195                 200                 205             


Leu Trp Ala Leu Pro Tyr Ser Leu Pro Ile His Pro Gly Arg Trp Trp 
    210                 215                 220                 


Val His Thr Arg Ala Ile Tyr Leu Pro Leu Gly Phe Val Ser Ser Asn 
225                 230                 235                 240 


Arg Ile His Cys Lys Leu Asp Pro Leu Leu Glu Gln Leu Arg Thr Glu 
                245                 250                 255     


Ile Tyr Leu Pro Arg Gln Leu Pro Tyr Thr Ser Ile Asp Phe Ser Gln 
            260                 265                 270         


His Arg Asn Asp Val Cys Gly Ile Asp Leu Tyr Tyr Pro His Thr Lys 
        275                 280                 285             


Val Leu Asn Met Ala Asn Tyr Val Leu Ser Lys Tyr Glu Gly Trp Arg 
    290                 295                 300                 


Pro Lys Trp Val Leu Asp Trp Ile Asn Lys Arg Ala Tyr Asp Leu Ile 
305                 310                 315                 320 


Leu Lys Glu Tyr His Asn Thr Glu Tyr Leu Cys Ile Ala Pro Val Asn 
                325                 330                 335     


Phe Ala Phe Asn Met Val Val Thr His Phe Tyr Glu Gly Pro Lys Ser 
            340                 345                 350         


Glu Asn Phe Ala Lys Leu Gln Ala Arg Met Asn Asp Val Leu Phe His 
        355                 360                 365             


Gly Pro Gln Gly Met Thr Val Met Gly Thr Asn Gly Val Gln Val Trp 
    370                 375                 380                 


Asp Ala Ala Phe Met Val Gln Tyr Phe Phe Met Ala Gly Leu Ala Asp 
385                 390                 395                 400 


Leu Pro Arg Tyr His Asp Met Ile Arg Lys Ser Tyr Met Phe Leu Val 
                405                 410                 415     


Arg Ser Gln Phe Thr Glu Asp Cys Val Asp Gly Ser Phe Arg Asp Lys 
            420                 425                 430         


Arg Lys Gly Ala Trp Pro Phe Ser Thr Lys Glu Gln Gly Tyr Thr Val 
        435                 440                 445             


Ser Asp Cys Thr Ala Glu Ala Leu Lys Ala Ile Ile Met Val Arg Asn 
    450                 455                 460                 


His Pro Ala Phe Ala Asp Leu Val Asp Glu Ile Lys Glu Glu Asp Leu 
465                 470                 475                 480 


Phe Asn Ala Val Asp Val Leu Leu Asn Ile Gln Asn Val Gly Asn Phe 
                485                 490                 495     


Glu Phe Gly Ser Phe Ser Ala Tyr Glu Lys Ile Arg Ser Thr Leu Leu 
            500                 505                 510         


Leu Glu Lys Leu Asn Pro Ala Glu Val Phe Asn Asn Ile Met Val Glu 
        515                 520                 525             


Tyr Pro Tyr Val Glu Cys Thr Asp Ser Ser Val Leu Gly Leu Thr Phe 
    530                 535                 540                 


Phe Ala Lys Tyr Tyr Pro Asn His Lys Pro Glu Val Ile Ser Thr Ala 
545                 550                 555                 560 


Ile Glu Arg Ala Ile Lys Tyr Ile Ile Ser Ala Gln Asp Glu Ile Asp 
                565                 570                 575     


Gly Ser Trp Tyr Gly Ala Trp Gly Ile Cys Tyr Thr Tyr Ala Ser Met 
            580                 585                 590         


Phe Ala Leu Glu Ala Leu Asn Thr Val Gly Leu Asn Tyr Glu Asn Ser 
        595                 600                 605             


Ala Thr Val Lys Arg Gly Cys Asp Phe Leu Ile Ser Lys Gln Leu Pro 
    610                 615                 620                 


Asp Gly Gly Trp Ser Glu Ser Met Lys Ala Cys Glu Thr His Ser Tyr 
625                 630                 635                 640 


Val Asn Gly Asp Lys Ser Tyr Val Val Gln Thr Ala Trp Ala Val Ile 
                645                 650                 655     


Gly Leu Ile Leu Gly Gly Tyr Pro Asp Gln Glu Pro Ile Arg Lys Gly 
            660                 665                 670         


Ile Gln Leu Leu Met Gln Arg Gln Leu Pro Thr Gly Glu Trp Lys Phe 
        675                 680                 685             


Glu Glu Val Glu Gly Val Phe Asn His Ser Cys Ala Ile Glu Tyr Pro 
    690                 695                 700                 


Ser Tyr Lys Phe Leu Phe Pro Ile Lys Ala Leu Gly Leu Tyr His Gln 
705                 710                 715                 720 


Lys Phe Gly Asn Glu Pro Ile Val 
                725             


<210>  63
<211>  721
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  63

Met Glu Ala Cys Arg Val Arg Pro Glu Leu Ser Lys Thr Val Glu Gln 
1               5                   10                  15      


Ile Asp Lys Ser Leu Trp Arg Leu Asn Ile Asp Ser Ala Gly Gly Glu 
            20                  25                  30          


Thr Trp Glu Tyr Val Thr Lys Glu Glu Ala Glu Lys Arg Pro Leu Thr 
        35                  40                  45              


Ile Ala Glu Lys Tyr Phe Leu Gly Phe Asp Leu Asp Leu Pro Lys Arg 
    50                  55                  60                  


Pro Pro Ala Lys Thr Pro Leu Glu Ser Ala Glu Tyr Gly Tyr Glu Phe 
65                  70                  75                  80  


Phe Arg Arg Leu Gln Leu Pro Asp Gly His Trp Ala Ser Pro Tyr Glu 
                85                  90                  95      


Gly Pro Met Phe Leu Ile Cys Gly Ala Val Phe Ala Phe Tyr Ile Ser 
            100                 105                 110         


Gln Thr Pro Phe Pro Lys Gly Trp Ala Pro Glu Ile Ile Gln Tyr Leu 
        115                 120                 125             


Ile Asn His Thr Asn Asp Asp Gly Gly Trp Gly Ile His Thr Glu Gly 
    130                 135                 140                 


Val Ser Thr Val Phe Gly Thr Ser Met Asn Tyr Val Val Leu Arg Ile 
145                 150                 155                 160 


Leu Gly Met Asp Ala Gly His Pro Val Ala Thr Arg Ala Arg Asn Arg 
                165                 170                 175     


Leu His Glu Leu Gly Gly Ala Ile Gly Cys Pro His Trp Gly Lys Phe 
            180                 185                 190         


Trp Leu Ala Thr Leu Asn Cys Tyr Asp Trp Asp Gly Val Asn Pro Ile 
        195                 200                 205             


Pro Pro Glu Leu Trp Leu Leu Pro Asp Trp Ile Pro Phe His Pro Gly 
    210                 215                 220                 


Lys Trp Trp Cys His Val Arg Leu Val Tyr Leu Pro Met Gly Tyr Met 
225                 230                 235                 240 


Tyr Gly Glu Arg Leu Lys Cys Pro Lys Asp Ser Leu Ile Met Gln Leu 
                245                 250                 255     


Arg Lys Glu Leu Tyr Val Glu Asn Tyr Asp Ser Ile Asn Phe Ala Asp 
            260                 265                 270         


His Arg Asn Thr Ile Ser Asp Val Asp Leu Tyr Phe Pro His Thr Gln 
        275                 280                 285             


Ile Leu Asp Arg Leu Asn Trp Ile Leu Glu Lys Tyr Phe Thr Tyr Leu 
    290                 295                 300                 


Arg Pro Ser Trp Leu Lys Lys Leu Gly Thr Arg Arg Ala Tyr Glu Leu 
305                 310                 315                 320 


Ile Lys Ile Glu Asp Gln Asn Thr Asp Tyr Ser Cys Ile Gly Pro Val 
                325                 330                 335     


Asn Ala Ala Met Asn Thr Val Cys Val Tyr Phe His Glu Gly Pro Ser 
            340                 345                 350         


Ser Lys Ala Phe Gln Lys His Ile Gln Arg Leu His Asp Phe Met Trp 
        355                 360                 365             


Val Gln Pro Glu Gly Met Leu Met Arg Gly Thr Asn Gly Leu Gln Val 
    370                 375                 380                 


Trp Glu Thr Ser Phe Thr Leu Gln Ala Leu Val Glu Ser Gly Leu Tyr 
385                 390                 395                 400 


Glu Lys Glu Ala Phe Lys Pro Asp Ile Ala Lys Ala Leu Glu Phe Leu 
                405                 410                 415     


Asp Arg Gln Gln Ile Arg Thr Gln Tyr Glu Gly Ser Gly Tyr Arg Tyr 
            420                 425                 430         


Asn Ser Leu Gly Ala Trp Pro Phe Ser Asn Ile Thr Gln Gly Tyr Thr 
        435                 440                 445             


Val Ser Asp Thr Thr Ser Glu Ala Leu Arg Ala Val Leu Leu Val Gln 
    450                 455                 460                 


Ser Leu Pro Asp Phe Glu Lys Leu Val Asp Ile Pro Arg Leu Arg Leu 
465                 470                 475                 480 


Ser Val Asp Val Ile Leu Gly Met Gln Asn Glu Asn Leu Gly Phe Ala 
                485                 490                 495     


Ser Tyr Glu Pro Ala Arg Thr Gly Glu Trp Met Glu Leu Leu Asn Pro 
            500                 505                 510         


Ala Glu Val Phe Gly Asn Ile Met Val Glu Tyr Ser Tyr Pro Glu Cys 
        515                 520                 525             


Thr Thr Ser Val Ile Leu Ala Leu Arg Ala Phe Thr Lys Tyr Asp Pro 
    530                 535                 540                 


Gly Tyr Arg Arg Asp Glu Ile Glu Asn Thr Ile Glu Asn Ala Leu Glu 
545                 550                 555                 560 


Tyr Val Val Lys Met Gln Arg Pro Asp Gly Ser Trp Tyr Gly Ser Trp 
                565                 570                 575     


Ala Ile Cys Phe Thr Tyr Ala Ala Met Phe Ala Thr Gly Ser Leu Ala 
            580                 585                 590         


Ser Ala Gly Arg Tyr Tyr Glu Asn Cys Pro Val Gln Lys Lys Ala Cys 
        595                 600                 605             


Glu Phe Leu Leu Ser Lys Gln Arg Pro Asp Gly Gly Trp Ser Glu Ser 
    610                 615                 620                 


Tyr Met Ala Cys Val Thr Gly Val Tyr Thr Glu Thr Glu Ser Ser Leu 
625                 630                 635                 640 


Val Thr Gln Thr Gly Trp Ala Leu Asp Ala Leu Ile Asn Ala Lys Tyr 
                645                 650                 655     


Pro Asp Arg Lys Pro Ile Glu Lys Gly Ile Lys Phe Leu Met Ala Ser 
            660                 665                 670         


Gln Lys Ser Asp Gly Ser Trp Gln Gln Lys Ser Met Glu Gly Ile Phe 
        675                 680                 685             


Asn Lys Asn Val Ala Ile Ala Tyr Pro Asn Tyr Lys Leu Tyr Phe Ser 
    690                 695                 700                 


Ile Tyr Thr Leu Gly Lys Phe Ala Lys Gln Tyr Gly Asn Tyr Leu Thr 
705                 710                 715                 720 


Ile 
    


<210>  64
<211>  721
<212>  PRT
<213>  Pichia pastoris

<400>  64

Met Thr Val Tyr Tyr Ser Glu Lys Ile Gly Leu Pro Lys Thr Asp Pro 
1               5                   10                  15      


Gln Arg Trp Arg Leu Arg Val Asn Glu Leu Gly Arg Gln Tyr Trp Asp 
            20                  25                  30          


Tyr Ile Glu Lys Glu Asp Leu Lys Asn Asp Pro Gln Thr Pro Tyr Val 
        35                  40                  45              


Gln Tyr Leu Leu Lys Gly Asp Glu Phe Glu Cys Pro Ile Pro Glu Lys 
    50                  55                  60                  


Pro Gln Ser Ala Phe Glu Ser Ala Arg Asn Cys Ala Asp Phe Leu Ala 
65                  70                  75                  80  


Leu Ile Gln Asp Glu Ser Gly Val Phe Pro Cys Gln Tyr Lys Gly Pro 
                85                  90                  95      


Met Phe Met Ser Ile Gly Tyr Val Val Ala Cys Tyr Phe Thr Asn Thr 
            100                 105                 110         


Pro Ile Pro Asp His Val Arg Thr Glu Met Ile Arg Tyr Val Val Asn 
        115                 120                 125             


Thr Ala His Pro Val Asp Gly Gly Trp Gly Leu His Glu Trp Asp Lys 
    130                 135                 140                 


Ser Thr Cys Phe Gly Thr Cys Met Asn Tyr Val Val Leu Arg Leu Leu 
145                 150                 155                 160 


Gly Leu Pro Lys Asp Asn Pro Val Cys Ile Lys Ala Arg Lys Val Leu 
                165                 170                 175     


His Ala Leu Gly Gly Ala Leu Ala Thr Pro Tyr Trp Gly Lys Ala Trp 
            180                 185                 190         


Leu Ser Leu Leu Asn Val Tyr Lys Trp Glu Gly Val Asn Pro Ala Pro 
        195                 200                 205             


Pro Glu Met Trp Asn Leu Pro Tyr Ser Leu Lys Ile His Pro Cys Arg 
    210                 215                 220                 


Trp Trp Val His Thr Arg Ala Ile Ala Leu Pro Leu Ser Tyr Ile Ser 
225                 230                 235                 240 


Ser Tyr Lys Ser Gln Met Pro Leu Thr Pro Leu Leu Lys Glu Leu Arg 
                245                 250                 255     


Asn Glu Ile Phe Leu Gln Asp Phe Asp Thr Ile Asp Phe Ser Lys His 
            260                 265                 270         


Arg Asn Asn Val Cys Gly Ile Asp Leu Tyr Tyr Pro His Thr Ser Leu 
        275                 280                 285             


Leu Asp Phe Ala Asn Ser Ile Leu Val Gly Tyr Asp Lys Ile Arg Pro 
    290                 295                 300                 


Thr Trp Leu Leu Lys Glu Ser Asn Asp Ala Val Tyr Glu Leu Ile Lys 
305                 310                 315                 320 


Lys Glu Leu Ala Asn Thr Glu His Leu Cys Ile Ala Pro Val Asn Ala 
                325                 330                 335     


Ala Phe Asn Thr Ile Val Ala Tyr Leu Glu Glu Gly Pro Glu Ser Tyr 
            340                 345                 350         


Asn Phe Lys Arg Leu Gln Glu Arg Phe Lys Asp Val Ile Phe His Gly 
        355                 360                 365             


Pro Gln Gly Met Thr Thr Met Gly Thr Asn Gly Thr Gln Val Trp Asp 
    370                 375                 380                 


Thr Ser Phe Cys Leu Gln Tyr Phe Phe Met Ala Gly Leu Ala Asp Leu 
385                 390                 395                 400 


Asp Glu Tyr Glu Glu Leu Ile Ile Arg Cys Phe Lys Phe Leu Ile Arg 
                405                 410                 415     


Ser Gln Phe Thr Thr Asp Thr Val Asp Gly Ser Tyr Arg Asp Lys Arg 
            420                 425                 430         


Ile Gly Cys Phe Pro Phe Ser Thr Lys Glu Gln Gly Tyr Thr Val Ser 
        435                 440                 445             


Asp Cys Thr Ala Glu Ala Ile Lys Ala Ile Leu Met Val Lys Asn His 
    450                 455                 460                 


Pro Lys Phe Ala Tyr Leu Gly Asp Tyr Ile Asp Glu Asp Leu Leu Lys 
465                 470                 475                 480 


Lys Gly Ile Asp Gly Leu Leu Ser Leu Gln Asn Val Gly Ser Tyr His 
                485                 490                 495     


Phe Gly Ser Phe Ser Thr Tyr Glu Ser Thr Arg Ala Asn Pro Ala Leu 
            500                 505                 510         


Glu Lys Ile Asn Pro Ala Glu Val Phe Gly Asn Ile Met Val Glu Tyr 
        515                 520                 525             


Pro Tyr Val Glu Cys Thr Asp Ser Ser Val Leu Gly Leu Thr Tyr Phe 
    530                 535                 540                 


Arg Glu His Trp Asp Tyr Arg Arg His Asp Ile Asp Thr Ala Ile Glu 
545                 550                 555                 560 


Arg Gly Val Lys Phe Ile Cys Asp Ala Gln Gln Glu Asp Gly Ser Trp 
                565                 570                 575     


Tyr Gly Cys Trp Gly Val Cys Phe Thr Tyr Ala Gly Met Phe Ala Leu 
            580                 585                 590         


Glu Ala Leu Ala Ser Val Asn Gln Tyr Tyr Glu Thr Asn Glu Val Val 
        595                 600                 605             


Arg Lys Gly Cys Asp Phe Leu Val Ser Lys Gln Met Ala Asp Gly Gly 
    610                 615                 620                 


Trp Ser Glu Ser Ile Lys Ser Cys Glu Thr His Thr Tyr Val Arg Gly 
625                 630                 635                 640 


Lys Arg Gly Met Val Val Gln Thr Ser Trp Val Leu Ile Gly Leu Ile 
                645                 650                 655     


Leu Ala Lys Tyr Pro His Lys Glu Val Ile Asp Arg Gly Val Gln Leu 
            660                 665                 670         


Ile Met Ser Arg Gln Lys Thr Arg Gly Asp Phe Asp Phe Glu Ala Val 
        675                 680                 685             


Glu Gly Ile Phe Asn His Ser Cys Gly Ile Glu Tyr Pro Asn Tyr Lys 
    690                 695                 700                 


Phe Leu Phe Pro Ile Lys Ala Leu Gly Leu Tyr Ser Lys Glu Tyr Glu 
705                 710                 715                 720 


Gln 
    


<210>  65
<211>  731
<212>  PRT
<213>  Kluyveromyces lactis

<400>  65

Met Pro Glu Leu Tyr Ser Glu Thr Ile Gly Leu Pro Arg Thr Asp Pro 
1               5                   10                  15      


Lys Arg Trp Arg Leu Ile Thr Asp Asp Leu Gly Arg Gln Thr Trp Glu 
            20                  25                  30          


Tyr Leu Ser Glu Asn Asp Ser Lys Lys Val Pro Gln Ser Thr Phe Ala 
        35                  40                  45              


Arg Trp Leu Leu Lys Cys Glu Asp Phe Pro Glu Pro His Pro Glu Ile 
    50                  55                  60                  


Asn Ser Lys Thr Ser Gly Phe Thr Ala Trp Asn Ala Ala His Asn Gly 
65                  70                  75                  80  


Ala Lys Phe Phe Glu Leu Leu Gln Asp Pro Asp Ser Gly Thr Phe Pro 
                85                  90                  95      


Cys Gln Tyr Lys Gly Pro Met Phe Met Thr Ile Gly Tyr Val Val Thr 
            100                 105                 110         


Met Tyr Ile Ala Lys Ile Glu Ile Pro Glu His Glu Lys Ala Glu Met 
        115                 120                 125             


Ile Arg Tyr Val Ala Asn Tyr Ala His Pro Val Asp Gly Gly Trp Gly 
    130                 135                 140                 


Leu His His Val Asp Lys Ser Thr Val Leu Gly Thr Val Leu Asn Tyr 
145                 150                 155                 160 


Val Met Met Arg Leu Leu Gly Leu Pro Lys Asp His Glu Val Cys Val 
                165                 170                 175     


Arg Ala Arg Asp Thr Leu Leu Arg Leu Gly Gly Ala Ile Ala Ser Pro 
            180                 185                 190         


His Trp Ala Lys Ile Trp Leu Ser Ile Leu Asn Leu Tyr Lys Trp Glu 
        195                 200                 205             


Gly Val Asn Pro Ala Pro Pro Glu Leu Trp Met Leu Pro Tyr Gly Leu 
    210                 215                 220                 


Asn Ile His Pro Ala Arg Trp Trp Val His Thr Arg Gly Ile Tyr Leu 
225                 230                 235                 240 


Pro Val Ser Tyr Leu Ser Ser Thr Gln Tyr Ser Cys Glu Leu Asp Pro 
                245                 250                 255     


Leu Leu Glu Glu Ile Arg Thr Glu Ile Tyr Thr Gln Pro Phe Glu Thr 
            260                 265                 270         


Ile Asp Phe Lys Lys His Arg Asn Thr Val Cys Gly Val Asp Leu Tyr 
        275                 280                 285             


Tyr Pro His Thr Lys Val Leu Asp Thr Met Asn Tyr Phe Ile Ser Lys 
    290                 295                 300                 


Tyr Glu Arg Tyr Val Arg Pro Asn Trp Leu Leu Lys Lys Ser Thr Asn 
305                 310                 315                 320 


Arg Val Tyr Glu Leu Val Lys Lys Glu Ile Ala Asn Thr Asp Tyr Leu 
                325                 330                 335     


Cys Ile Ala Pro Val Asn Asn Ala Phe Cys Ala Ile Val Thr Leu Ile 
            340                 345                 350         


Glu Glu Gly Lys Asp Ser Glu Glu Phe Gly Arg Phe Leu Tyr Arg Phe 
        355                 360                 365             


Lys Asp Val Leu Phe His Gly Pro Gln Gly Leu Thr Val Met Gly Thr 
    370                 375                 380                 


Asn Gly Val Gln Val Trp Asp Cys Ala Phe Tyr Ile Gln Tyr Met Phe 
385                 390                 395                 400 


Met Ala Gly Leu Ala Glu Leu Pro Glu Phe His Glu Thr Ile Val Arg 
                405                 410                 415     


Ser Phe Lys Phe Leu Cys Arg Ser Gln Phe Thr Glu Asp Cys Val Glu 
            420                 425                 430         


Gly Ser Phe Arg Asp Lys Arg Leu Gly Ala Trp Pro Phe Ser Thr Lys 
        435                 440                 445             


Thr Gln Gly Tyr Thr Val Ser Asp Cys Thr Ala Glu Ala Ile Lys Ala 
    450                 455                 460                 


Ile Ile Met Val Leu Asn Ser Asp Lys Tyr Arg Asp Val Trp Gly Val 
465                 470                 475                 480 


Tyr Asp Thr Glu Lys Leu Lys Asn Gly Ile Asp Val Leu Leu Gly Leu 
                485                 490                 495     


Gln Asn Leu Ser Ser Phe Glu Tyr Gly Ser Phe Ala Thr Tyr Glu Lys 
            500                 505                 510         


Ile Lys Ala Pro Leu Leu Met Glu Lys Leu Asn Pro Ala Glu Val Phe 
        515                 520                 525             


Gly Asn Ile Met Val Glu Phe Pro Tyr Val Glu Cys Thr Asp Ser Ser 
    530                 535                 540                 


Val Leu Gly Leu Thr Tyr Phe Arg Arg Tyr Phe Asn Tyr Arg Lys Lys 
545                 550                 555                 560 


Asp Ile Asp His Ala Ile Asp Ser Ala Ile Ala Tyr Ile Lys Lys Ser 
                565                 570                 575     


Gln Gln Pro Asn Gly Ser Trp Tyr Gly Cys Trp Gly Ile Cys Tyr Thr 
            580                 585                 590         


Tyr Ala Gly Met Phe Ala Leu Glu Ala Leu Asn Thr Ile Gly Glu Thr 
        595                 600                 605             


Tyr Glu Asn Ser Glu Val Val Arg Lys Gly Cys Asp Phe Phe Val Thr 
    610                 615                 620                 


Lys Gln Leu Pro Asp Gly Gly Trp Ser Glu Lys Met Lys Ser Ser Glu 
625                 630                 635                 640 


Leu His Thr Tyr Val Ser Asp Lys Glu Ser Tyr Val Val Gln Thr Ala 
                645                 650                 655     


Trp Val Leu Ile Gly Leu Ile Leu Ala Lys Phe Pro Asp Lys Ser Val 
            660                 665                 670         


Ile Asp Arg Ala Ile Asn Leu Leu Lys Gln Arg Gln Gln Pro Ser Gly 
        675                 680                 685             


Glu Trp Lys Tyr Glu Ala Val Glu Gly Val Phe Asn His Ser Cys Ala 
    690                 695                 700                 


Ile Glu Tyr Pro Ser Tyr Arg Phe Leu Phe Pro Ile Lys Ala Leu Gly 
705                 710                 715                 720 


Leu Tyr Val Lys Glu Tyr Gly His Ser Ala Ile 
                725                 730     


<210>  66
<211>  731
<212>  PRT
<213>  Kluyveromyces marxianus

<400>  66

Met Leu Glu Leu Tyr Ser Glu Lys Ile Lys Leu Pro Arg Thr Asp Pro 
1               5                   10                  15      


Thr Arg Trp Arg Leu His Thr Asp Asp Leu Gly Arg Glu Thr Trp Glu 
            20                  25                  30          


Tyr Leu Ser Val Glu Glu Ser Lys Lys Ile Pro Gln Ser Thr Phe Ala 
        35                  40                  45              


Gln Trp Leu Leu Gln Cys Glu Glu Phe Pro Glu Pro Gln Pro Gln Val 
    50                  55                  60                  


Asn Ser Lys Thr Ser Asn Phe Thr Ala Trp Asn Ala Ala His Asn Gly 
65                  70                  75                  80  


Ala Lys Phe Phe Glu Leu Leu Gln Asp Pro Asn Ser Gly Ile Phe Pro 
                85                  90                  95      


Cys Gln Tyr Lys Gly Pro Met Phe Met Thr Ile Gly Tyr Val Ala Thr 
            100                 105                 110         


Met Tyr Leu Ala Lys Leu Glu Ile Pro Glu His Glu Arg Ile Glu Leu 
        115                 120                 125             


Ile Arg Tyr Ile Ala Asn Tyr Ala His Pro Val Asp Gly Gly Trp Gly 
    130                 135                 140                 


Leu His Thr Thr Asp Lys Ser Thr Val Leu Gly Thr Val Leu Asn Tyr 
145                 150                 155                 160 


Val Ser Leu Arg Leu Leu Gly Leu Pro Lys Asp His Glu Val Cys Thr 
                165                 170                 175     


Arg Ala Arg Asp Thr Leu His Arg Leu Gly Gly Ala Ile Gly Ser Pro 
            180                 185                 190         


His Trp Ala Lys Ile Trp Leu Ser Ile Leu Asn Leu Tyr Lys Trp Glu 
        195                 200                 205             


Gly Val Asn Pro Ala Pro Pro Glu Leu Trp Met Phe Pro Tyr Ser Leu 
    210                 215                 220                 


Pro Ile His Pro Ala Arg Trp Trp Val His Thr Arg Gly Ile Tyr Leu 
225                 230                 235                 240 


Pro Val Ser Tyr Leu Ser Ser Thr Arg Tyr Thr Cys Asp Leu Asp Pro 
                245                 250                 255     


Leu Leu Lys Glu Ile Arg Ser Glu Ile Tyr Ile Lys Pro Phe Glu Thr 
            260                 265                 270         


Ile Asn Phe Thr Glu His Arg Asn Thr Val Cys Gly Val Asp Leu Tyr 
        275                 280                 285             


Tyr Pro His Thr Lys Val Leu Asn Thr Val Asn Ala Met Met Thr Cys 
    290                 295                 300                 


Tyr Glu Lys Tyr Ile Arg Pro Asn Trp Met Leu Lys Lys Ala Thr Lys 
305                 310                 315                 320 


Arg Val Tyr Glu Leu Val Lys Lys Glu Ile Ala Asn Thr Asp Tyr Leu 
                325                 330                 335     


Cys Ile Ala Pro Val Asn Met Ala Phe Cys Ala Ile Val Thr Leu Ile 
            340                 345                 350         


Glu Glu Gly Lys Asp Ser Thr Glu Phe Asn Ser Phe Leu Tyr Arg Phe 
        355                 360                 365             


Lys Asp Val Leu Phe His Gly Pro Gln Gly Leu Thr Val Met Gly Thr 
    370                 375                 380                 


Asn Gly Val Gln Val Trp Asp Cys Ala Phe Phe Val Gln Tyr Met Phe 
385                 390                 395                 400 


Thr Ala Gly Leu Ala Glu Leu Pro Glu Phe His Asp Ser Val Ala Arg 
                405                 410                 415     


Ser Phe Lys Phe Leu Cys Arg Ser Gln Phe Thr Glu Asn Cys Ala Asp 
            420                 425                 430         


Gly Ser Phe Arg Asp Lys Arg Leu Gly Ala Trp Pro Phe Ser Thr Lys 
        435                 440                 445             


Thr Gln Gly Tyr Thr Val Ser Asp Cys Thr Ala Glu Ala Ile Lys Ala 
    450                 455                 460                 


Ile Ile Met Val Leu Asn Ser Ala Ser Phe Lys Asp Val His Asp Tyr 
465                 470                 475                 480 


Tyr Asp Pro Lys Lys Leu Asn Asn Gly Ile Asp Val Leu Leu Ser Leu 
                485                 490                 495     


Gln Asn Val Ser Ser Phe Glu Tyr Gly Ser Phe Ser Thr Tyr Glu Lys 
            500                 505                 510         


Ile Lys Ala Thr Thr Leu Leu Glu Lys Leu Asn Pro Ala Glu Val Phe 
        515                 520                 525             


Gly Asn Ile Met Val Glu Tyr Pro Tyr Val Glu Cys Thr Asp Ser Ser 
    530                 535                 540                 


Val Leu Gly Leu Thr Tyr Phe Arg Lys His Phe Asp Tyr Arg Lys Lys 
545                 550                 555                 560 


Asp Ile Asp Phe Ala Ile Lys Glu Ala Ile Ala Tyr Ile Lys Asn Val 
                565                 570                 575     


Gln Asn Glu Asp Gly Ser Trp Tyr Gly Cys Trp Gly Ile Cys Tyr Thr 
            580                 585                 590         


Tyr Ala Gly Met Phe Ala Leu Glu Ala Leu Tyr Thr Val Gly Glu Asn 
        595                 600                 605             


Tyr Glu Asn Ser Glu Val Val Arg Lys Gly Cys Asp Phe Leu Val Ser 
    610                 615                 620                 


Lys Gln Leu Pro Asp Gly Gly Trp Ser Glu Thr Met Lys Ser Ser Glu 
625                 630                 635                 640 


Leu His Ser Tyr Val Ser Asp Lys Thr Ser Tyr Val Val Gln Thr Ala 
                645                 650                 655     


Trp Ala Ile Ile Gly Leu Ile Leu Ala Lys Tyr Pro Asn Lys His Val 
            660                 665                 670         


Ile Asp Arg Gly Ile Lys Leu Leu Lys Glu Arg Gln Gln Pro Ser Gly 
        675                 680                 685             


Glu Trp Lys Phe Glu Ala Val Glu Gly Val Phe Asn His Ser Cys Ala 
    690                 695                 700                 


Ile Glu Tyr Pro Ser Tyr Arg Phe Leu Phe Pro Ile Lys Ala Leu Gly 
705                 710                 715                 720 


Leu Tyr Val Lys Glu Tyr Lys Asp Asn Ala Ile 
                725                 730     


<210>  67
<211>  728
<212>  PRT
<213>  Candida albicans

<400>  67

Met Tyr Tyr Ser Glu Glu Ile Gly Leu Pro Lys Thr Asp Ile Ser Arg 
1               5                   10                  15      


Trp Arg Leu Arg Ser Asp Ala Leu Gly Arg Glu Thr Trp His Tyr Leu 
            20                  25                  30          


Ser Gln Ser Glu Cys Glu Ser Glu Pro Gln Ser Thr Phe Val Gln Trp 
        35                  40                  45              


Leu Leu Glu Ser Pro Asp Phe Pro Ser Pro Pro Ser Ser Asp Ile His 
    50                  55                  60                  


Thr Pro Asp Glu Ala Ala Arg Lys Gly Ala Asp Phe Leu Lys Leu Leu 
65                  70                  75                  80  


Gln Leu Asp Asn Gly Ile Phe Pro Cys Gln Tyr Lys Gly Pro Met Phe 
                85                  90                  95      


Met Thr Ile Gly Tyr Val Thr Ala Asn Tyr Tyr Ser Lys Thr Glu Ile 
            100                 105                 110         


Pro Glu Pro Tyr Arg Val Glu Met Ile Arg Tyr Ile Val Asn Thr Ala 
        115                 120                 125             


His Pro Val Asp Gly Gly Trp Gly Leu His Ser Val Asp Lys Ser Thr 
    130                 135                 140                 


Cys Phe Gly Thr Thr Met Asn Tyr Val Cys Leu Arg Leu Leu Gly Met 
145                 150                 155                 160 


Glu Lys Asp His Pro Val Leu Val Lys Ala Arg Lys Thr Leu His Arg 
                165                 170                 175     


Leu Gly Gly Ala Ile Lys Asn Pro His Trp Gly Lys Ala Trp Leu Ser 
            180                 185                 190         


Ile Leu Asn Leu Tyr Glu Trp Glu Gly Val Asn Pro Ala Pro Pro Glu 
        195                 200                 205             


Leu Trp Arg Leu Pro Tyr Trp Leu Pro Ile His Pro Ala Lys Trp Trp 
    210                 215                 220                 


Val His Thr Arg Ala Ile Tyr Leu Pro Leu Gly Tyr Thr Ser Ala Asn 
225                 230                 235                 240 


Arg Val Gln Cys Glu Leu Asp Pro Leu Leu Lys Glu Ile Arg Asn Glu 
                245                 250                 255     


Ile Tyr Val Pro Ser Gln Leu Pro Tyr Glu Ser Ile Lys Phe Gly Asn 
            260                 265                 270         


Gln Arg Asn Asn Val Cys Gly Val Asp Leu Tyr Tyr Pro His Thr Lys 
        275                 280                 285             


Ile Leu Asp Phe Ala Asn Ser Ile Leu Ser Lys Trp Glu Ala Val Arg 
    290                 295                 300                 


Pro Lys Trp Leu Leu Asn Trp Val Asn Lys Lys Val Tyr Asp Leu Ile 
305                 310                 315                 320 


Val Lys Glu Tyr Gln Asn Thr Glu Tyr Leu Cys Ile Ala Pro Val Ser 
                325                 330                 335     


Phe Ala Phe Asn Met Val Val Thr Cys His Tyr Glu Gly Ser Glu Ser 
            340                 345                 350         


Glu Asn Phe Lys Lys Leu Gln Asn Arg Met Asn Asp Val Leu Phe His 
        355                 360                 365             


Gly Pro Gln Gly Met Thr Val Met Gly Thr Asn Gly Val Gln Val Trp 
    370                 375                 380                 


Asp Ala Ala Phe Met Val Gln Tyr Phe Phe Met Thr Gly Leu Val Asp 
385                 390                 395                 400 


Asp Pro Lys Tyr His Asp Met Ile Arg Lys Ser Tyr Leu Phe Leu Val 
                405                 410                 415     


Arg Ser Gln Phe Thr Glu Asn Cys Val Asp Gly Ser Phe Arg Asp Arg 
            420                 425                 430         


Arg Lys Gly Ala Trp Pro Phe Ser Thr Lys Glu Gln Gly Tyr Thr Val 
        435                 440                 445             


Ser Asp Cys Thr Ala Glu Ala Met Lys Ala Ile Ile Met Val Arg Asn 
    450                 455                 460                 


His Ala Ser Phe Ala Asp Ile Arg Asp Glu Ile Lys Asp Glu Asn Leu 
465                 470                 475                 480 


Phe Asp Ala Val Glu Val Leu Leu Gln Ile Gln Asn Val Gly Glu Trp 
                485                 490                 495     


Glu Tyr Gly Ser Phe Ser Thr Tyr Glu Gly Ile Lys Ala Pro Leu Leu 
            500                 505                 510         


Leu Glu Lys Leu Asn Pro Ala Glu Val Phe Asn Asn Ile Met Val Glu 
        515                 520                 525             


Tyr Pro Tyr Val Glu Cys Thr Asp Ser Ser Val Leu Gly Leu Thr Tyr 
    530                 535                 540                 


Phe Ala Lys Tyr Tyr Pro Asp Tyr Lys Pro Glu Leu Ile Gln Lys Thr 
545                 550                 555                 560 


Ile Ser Ser Ala Ile Gln Tyr Ile Leu Asp Ser Gln Asp Asn Ile Asp 
                565                 570                 575     


Gly Ser Trp Tyr Gly Cys Trp Gly Ile Cys Tyr Thr Tyr Ala Ser Met 
            580                 585                 590         


Phe Ala Leu Glu Ala Leu His Thr Val Gly Leu Asp Tyr Glu Ser Ser 
        595                 600                 605             


Ser Ala Val Lys Lys Gly Cys Asp Phe Leu Ile Ser Lys Gln Leu Pro 
    610                 615                 620                 


Asp Gly Gly Trp Ser Glu Ser Met Lys Gly Cys Glu Thr His Ser Tyr 
625                 630                 635                 640 


Val Asn Gly Glu Asn Ser Leu Val Val Gln Ser Ala Trp Ala Leu Ile 
                645                 650                 655     


Gly Leu Ile Leu Gly Asn Tyr Pro Asp Glu Glu Pro Ile Lys Arg Gly 
            660                 665                 670         


Ile Gln Phe Leu Met Lys Arg Gln Leu Pro Thr Gly Glu Trp Lys Tyr 
        675                 680                 685             


Glu Asp Ile Glu Gly Val Phe Asn His Ser Cys Ala Ile Glu Tyr Pro 
    690                 695                 700                 


Ser Tyr Arg Phe Leu Phe Pro Ile Lys Ala Leu Gly Leu Tyr Lys Asn 
705                 710                 715                 720 


Lys Tyr Gly Asp Lys Val Leu Val 
                725             


