﻿                         序列表

<110>  青岛清原化合物有限公司

<120>  一种随机突变的基因编辑系统及其应用

<130>  20190402

<150>  2018103296833
<151>  2018-04-13

<160>  3

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  713
<212>  DNA
<213>  sgRNA1-1表达盒序列(sgRNA1-1)

<400>  1
cgacttgcct tccgcacaat acatcatttc ttcttagctt tttttcttct tcttcgttca        60
tacagttttt ttttgtttat cagcttacat tttcttgaac cgtagctttc gttttcttct       120
ttttaacttt ccattcggag tttttgtatc ttgtttcata gtttgtccca ggattagaat       180
gattaggcat cgaaccttca agaatttgat tgaataaaac atcttcattc ttaagatatg       240
aagataatct tcaaaaggcc cctgggaatc tgaaagaaga gaagcaggcc catttatatg       300
ggaaagaaca atagtatttc ttatataggc ccatttaagt tgaaaacaat cttcaaaagt       360
cccacatcgc ttagataaga aaacgaagct gagtttatat acagctagag tcgaagtagt       420
gattgcctga ccgccgaacc atggcgtttt agagctagaa atagcaagtt aaaataaggc       480
tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg cttttttttg caaaattttc       540
cagatcgatt tcttcttcct ctgttcttcg gcgttcaatt tctggggttt tctcttcgtt       600
ttctgtaact gaaacctaaa atttgaccta aaaaaaatct caaataatat gattcagtgg       660
ttttgtactt ttcagttagt tgagttttgc agttccgatg agataaacca ata              713

<210>  2
<211>  573
<212>  DNA
<213>  sgRNA2-1表达盒序列(sgRNA2-1)

<400>  2
ttaatccaaa ctactgcagc ctgacagaca aatgaggatg caaacaattt taaagtttat        60
ctaacgctag ctgttttgtt tcttctctct ggtgcaccaa cgacggcgtt ttctcaatca       120
taaagaggct tgttttactt aaggccaata atgttgatgg atcgaaagaa gagggctttt       180
aataaacgag cccgtttaag ctgtaaacga tgtcaaaaac atcccacatc gttcagttga       240
aaatagaagc tctgtttata tattggtaga gtcgactaag agattgttgc ctgaccgccg       300
aaccagtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa       360
aaagtggcac cgagtcggtg cttttttttg caaaattttc cagatcgatt tcttcttcct       420
ctgttcttcg gcgttcaatt tctggggttt tctcttcgtt ttctgtaact gaaacctaaa       480
atttgaccta aaaaaaatct caaataatat gattcagtgg ttttgtactt ttcagttagt       540
tgagttttgc agttccgatg agataaacca ata                                    573

<210>  3
<211>  16484
<212>  DNA
<213>  载体全序列(pHEE401E+PDS1+2)

<400>  3
gtttacccgc caatatatcc tgtcaaacac tgatagttta aactgaaggc gggaaacgac        60
aatctgatcc aagctcaagc tgctctagca ttcgccattc aggctgcgca actgttggga       120
agggcgatcg gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc       180
aaggcgatta agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc       240
cagtgccaag cttcgacttg ccttccgcac aatacatcat ttcttcttag ctttttttct       300
tcttcttcgt tcatacagtt tttttttgtt tatcagctta cattttcttg aaccgtagct       360
ttcgttttct tctttttaac tttccattcg gagtttttgt atcttgtttc atagtttgtc       420
ccaggattag aatgattagg catcgaacct tcaagaattt gattgaataa aacatcttca       480
ttcttaagat atgaagataa tcttcaaaag gcccctggga atctgaaaga agagaagcag       540
gcccatttat atgggaaaga acaatagtat ttcttatata ggcccattta agttgaaaac       600
aatcttcaaa agtcccacat cgcttagata agaaaacgaa gctgagttta tatacagcta       660
gagtcgaagt agtgattgcc tgaccgccga accatggcgt tttagagcta gaaatagcaa       720
gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt       780
ttgcaaaatt ttccagatcg atttcttctt cctctgttct tcggcgttca atttctgggg       840
ttttctcttc gttttctgta actgaaacct aaaatttgac ctaaaaaaaa tctcaaataa       900
tatgattcag tggttttgta cttttcagtt agttgagttt tgcagttccg atgagataaa       960
ccaatattaa tccaaactac tgcagcctga cagacaaatg aggatgcaaa caattttaaa      1020
gtttatctaa cgctagctgt tttgtttctt ctctctggtg caccaacgac ggcgttttct      1080
caatcataaa gaggcttgtt ttacttaagg ccaataatgt tgatggatcg aaagaagagg      1140
gcttttaata aacgagcccg tttaagctgt aaacgatgtc aaaaacatcc cacatcgttc      1200
agttgaaaat agaagctctg tttatatatt ggtagagtcg actaagagat tgttgcctga      1260
ccgccgaacc agttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      1320
cttgaaaaag tggcaccgag tcggtgcttt tttttgcaaa attttccaga tcgatttctt      1380
cttcctctgt tcttcggcgt tcaatttctg gggttttctc ttcgttttct gtaactgaaa      1440
cctaaaattt gacctaaaaa aaatctcaaa taatatgatt cagtggtttt gtacttttca      1500
gttagttgag ttttgcagtt ccgatgagat aaaccaatac catggttata ctagtgaata      1560
aaagcatttg cgtttggttt atcattgcgt ttatacaagg acagagatcc actgagctgg      1620
aatagcttaa aaccattatc agaacaaaat aaaccatttt ttgttaagaa tcagagcata      1680
gtaaacaaca gaaacaacct aagagaggta acttgtccaa gaagatagct aattatatct      1740
attttataaa agttatcata gtttgtaagt cacaaaagat gcaaataaca gagaaactag      1800
gagacttgag aatatacatt cttgtatatt tgtattcgag attgtgaaaa tttgaccata      1860
agtttaaatt cttaaaaaga tatatctgat ctaggtgatg gttatagact gtaattttac      1920
cacatgttta atgatggata gtgacacaca tgacacatcg acaacactat agcatcttat      1980
ttagattaca acatgaaatt tttctgtaat acatgtcttt gtacataatt taaaagtaat      2040
tcctaagaaa tatatttata caaggagttt aaagaaaaca tagcataaag ttcaatgagt      2100
agtaaaaacc atatacagta tatagcataa agttcaatga gtttattaca aaagcattgg      2160
ttcactttct gtaacacgac gttaaacctt cgtctccaat aggagcgcta ctgattcaac      2220
atgccaatat atactaaata cgtttctaca gtcaaatgct ttaacgtttc atgattaagt      2280
gactatttac cgtcaatcct ttcccattcc tcccactaat ccaacttttt aattactctt      2340
aaatcaccac taagctagta acgcctatca tgaattagct ctactaaatc tagcaacctt      2400
tcaaatttgc agtattgcag gtgtctctgt gtctttaaaa tagttgcctt atgatttctt      2460
cggtttcaag atgatcaaat agttatagat ttcatgctca cacatgctca ttagatgtgt      2520
acatacttta cttacccaaa tctattttct cgcaaagatt ttgatggtaa agctgatttg      2580
gttctattga actaaatcaa acgagtttca gactgagtga ttctaatccg gcccattagc      2640
ccctaaacag acccactaat tacgcagctt ttaatagagt aattacacct agtttaccca      2700
ctaaaccact aagcactaat tatctcacaa tctaatgagc ttccctcgta attacttggg      2760
ctttcactct accatttatt tgtaacagtc aagtctctac tgtctctata taaactctct      2820
aaagttaaca cacaattctc atcacaaaca aatcaaccaa agcaacttct actctttctt      2880
ctttcgacct tatcaatctg ttgagaaatc tagatggatt acaaggacca cgacggggat      2940
tacaaggacc acgacattga ttacaaggat gatgatgaca agatggctcc gaagaagaag      3000
aggaaggttg gcatccacgg ggtgccagct gctgacaaga agtactcgat cggcctcgat      3060
attgggacta actctgttgg ctgggccgtg atcaccgacg agtacaaggt gccctcaaag      3120
aagttcaagg tcctgggcaa caccgatcgg cattccatca agaagaatct cattggcgct      3180
ctcctgttcg acagcggcga gacggctgag gctacgcggc tcaagcgcac cgcccgcagg      3240
cggtacacgc gcaggaagaa tcgcatctgc tacctgcagg agattttctc caacgagatg      3300
gcgaaggttg acgattcttt cttccacagg ctggaggagt cattcctcgt ggaggaggat      3360
aagaagcacg agcggcatcc aatcttcggc aacattgtcg acgaggttgc ctaccacgag      3420
aagtacccta cgatctacca tctgcggaag aagctcgtgg actccacaga taaggcggac      3480
ctccgcctga tctacctcgc tctggcccac atgattaagt tcaggggcca tttcctgatc      3540
gagggggatc tcaacccgga caatagcgat gttgacaagc tgttcatcca gctcgtgcag      3600
acgtacaacc agctcttcga ggagaacccc attaatgcgt caggcgtcga cgcgaaggct      3660
atcctgtccg ctaggctctc gaagtctcgg cgcctcgaga acctgatcgc ccagctgccg      3720
ggcgagaaga agaacggcct gttcgggaat ctcattgcgc tcagcctggg gctcacgccc      3780
aacttcaagt cgaatttcga tctcgctgag gacgccaagc tgcagctctc caaggacaca      3840
tacgacgatg acctggataa cctcctggcc cagatcggcg atcagtacgc ggacctgttc      3900
ctcgctgcca agaatctgtc ggacgccatc ctcctgtctg atattctcag ggtgaacacc      3960
gagattacga aggctccgct ctcagcctcc atgatcaagc gctacgacga gcaccatcag      4020
gatctgaccc tcctgaaggc gctggtcagg cagcagctcc ccgagaagta caaggagatc      4080
ttcttcgatc agtcgaagaa cggctacgct gggtacattg acggcggggc ctctcaggag      4140
gagttctaca agttcatcaa gccgattctg gagaagatgg acggcacgga ggagctgctg      4200
gtgaagctca atcgcgagga cctcctgagg aagcagcgga cattcgataa cggcagcatc      4260
ccacaccaga ttcatctcgg ggagctgcac gctatcctga ggaggcagga ggacttctac      4320
cctttcctca aggataaccg cgagaagatc gagaagattc tgactttcag gatcccgtac      4380
tacgtcggcc cactcgctag gggcaactcc cgcttcgctt ggatgacccg caagtcagag      4440
gagacgatca cgccgtggaa cttcgaggag gtggtcgaca agggcgctag cgctcagtcg      4500
ttcatcgaga ggatgacgaa tttcgacaag aacctgccaa atgagaaggt gctccctaag      4560
cactcgctcc tgtacgagta cttcacagtc tacaacgagc tgactaaggt gaagtatgtg      4620
accgagggca tgaggaagcc ggctttcctg tctggggagc agaagaaggc catcgtggac      4680
ctcctgttca agaccaaccg gaaggtcacg gttaagcagc tcaaggagga ctacttcaag      4740
aagattgagt gcttcgattc ggtcgagatc tctggcgttg aggaccgctt caacgcctcc      4800
ctggggacct accacgatct cctgaagatc attaaggata aggacttcct ggacaacgag      4860
gagaatgagg atatcctcga ggacattgtg ctgacactca ctctgttcga ggaccgggag      4920
atgatcgagg agcgcctgaa gacttacgcc catctcttcg atgacaaggt catgaagcag      4980
ctcaagagga ggaggtacac cggctggggg aggctgagca ggaagctcat caacggcatt      5040
cgggacaagc agtccgggaa gacgatcctc gacttcctga agagcgatgg cttcgcgaac      5100
cgcaatttca tgcagctgat tcacgatgac agcctcacat tcaaggagga tatccagaag      5160
gctcaggtga gcggccaggg ggactcgctg cacgagcata tcgcgaacct cgctggctcg      5220
ccagctatca agaaggggat tctgcagacc gtgaaggttg tggacgagct ggtgaaggtc      5280
atgggcaggc acaagcctga gaacatcgtc attgagatgg cccgggagaa tcagaccacg      5340
cagaagggcc agaagaactc acgcgagagg atgaagagga tcgaggaggg cattaaggag      5400
ctggggtccc agatcctcaa ggagcacccg gtggagaaca cgcagctgca gaatgagaag      5460
ctctacctgt actacctcca gaatggccgc gatatgtatg tggaccagga gctggatatt      5520
aacaggctca gcgattacga cgtcgatcat atcgttccac agtcattcct gaaggatgac      5580
tccattgaca acaaggtcct caccaggtcg gacaagaacc ggggcaagtc tgataatgtt      5640
ccttcagagg aggtcgttaa gaagatgaag aactactggc gccagctcct gaatgccaag      5700
ctgatcacgc agcggaagtt cgataacctc acaaaggctg agaggggcgg gctctctgag      5760
ctggacaagg cgggcttcat caagaggcag ctggtcgaga cacggcagat cactaagcac      5820
gttgcgcaga ttctcgactc acggatgaac actaagtacg atgagaatga caagctgatc      5880
cgcgaggtga aggtcatcac cctgaagtca aagctcgtct ccgacttcag gaaggatttc      5940
cagttctaca aggttcggga gatcaacaat taccaccatg cccatgacgc gtacctgaac      6000
gcggtggtcg gcacagctct gatcaagaag tacccaaagc tcgagagcga gttcgtgtac      6060
ggggactaca aggtttacga tgtgaggaag atgatcgcca agtcggagca ggagattggc      6120
aaggctaccg ccaagtactt cttctactct aacattatga atttcttcaa gacagagatc      6180
actctggcca atggcgagat ccggaagcgc cccctcatcg agacgaacgg cgagacgggg      6240
gagatcgtgt gggacaaggg cagggatttc gcgaccgtca ggaaggttct ctccatgcca      6300
caagtgaata tcgtcaagaa gacagaggtc cagactggcg ggttctctaa ggagtcaatt      6360
ctgcctaagc ggaacagcga caagctcatc gcccgcaaga aggactggga tccgaagaag      6420
tacggcgggt tcgacagccc cactgtggcc tactcggtcc tggttgtggc gaaggttgag      6480
aagggcaagt ccaagaagct caagagcgtg aaggagctgc tggggatcac gattatggag      6540
cgctccagct tcgagaagaa cccgatcgat ttcctggagg cgaagggcta caaggaggtg      6600
aagaaggacc tgatcattaa gctccccaag tactcactct tcgagctgga gaacggcagg      6660
aagcggatgc tggcttccgc tggcgagctg cagaagggga acgagctggc tctgccgtcc      6720
aagtatgtga acttcctcta cctggcctcc cactacgaga agctcaaggg cagccccgag      6780
gacaacgagc agaagcagct gttcgtcgag cagcacaagc attacctcga cgagatcatt      6840
gagcagattt ccgagttctc caagcgcgtg atcctggccg acgcgaatct ggataaggtc      6900
ctctccgcgt acaacaagca ccgcgacaag ccaatcaggg agcaggctga gaatatcatt      6960
catctcttca ccctgacgaa cctcggcgcc cctgctgctt tcaagtactt cgacacaact      7020
atcgatcgca agaggtacac aagcactaag gaggtcctgg acgcgaccct catccaccag      7080
tcgattaccg gcctctacga gacgcgcatc gacctgtctc agctcggggg cgacaagcgg      7140
ccagcggcga cgaagaaggc ggggcaggcg aagaagaaga agtgagctca gagctttcgt      7200
tcgtatcatc ggtttcgaca acgttcgtca agttcaatgc atcagtttca ttgcgcacac      7260
accagaatcc tactgagttt gagtattatg gcattgggaa aactgttttt cttgtaccat      7320
ttgttgtgct tgtaatttac tgtgtttttt attcggtttt cgctatcgaa ctgtgaaatg      7380
gaaatggatg gagaagagtt aatgaatgat atggtccttt tgttcattct caaattaata      7440
ttatttgttt tttctcttat ttgttgtgtg ttgaatttga aattataaga gatatgcaaa      7500
cattttgttt tgagtaaaaa tgtgtcaaat cgtggcctct aatgaccgaa gttaatatga      7560
ggagtaaaac acttgtagtt gtaccattat gcttattcac taggcaacaa atatattttc      7620
agacctagaa aagctgcaaa tgttactgaa tacaagtatg tcctcttgtg ttttagacat      7680
ttatgaactt tcctttatgt aattttccag aatccttgtc agattctaat cattgcttta      7740
taattatagt tatactcatg gatttgtagt tgagtatgaa aatatttttt aatgcatttt      7800
atgacttgcc aattgattga caacgaattc gtaatcatgt catagctgtt tcctgtgtga      7860
aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc      7920
tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc      7980
cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc      8040
ggtttgcgta ttggctagag cagcttgcca acatggtgga gcacgacact ctcgtctact      8100
ccaagaatat caaagataca gtctcagaag accaaagggc tattgagact tttcaacaaa      8160
gggtaatatc gggaaacctc ctcggattcc attgcccagc tatctgtcac ttcatcaaaa      8220
ggacagtaga aaaggaaggt ggcacctaca aatgccatca ttgcgataaa ggaaaggcta      8280
tcgttcaaga tgcctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca      8340
tcgtggaaaa agaagacgtt ccaaccacgt cttcaaagca agtggattga tgtgataaca      8400
tggtggagca cgacactctc gtctactcca agaatatcaa agatacagtc tcagaagacc      8460
aaagggctat tgagactttt caacaaaggg taatatcggg aaacctcctc ggattccatt      8520
gcccagctat ctgtcacttc atcaaaagga cagtagaaaa ggaaggtggc acctacaaat      8580
gccatcattg cgataaagga aaggctatcg ttcaagatgc ctctgccgac agtggtccca      8640
aagatggacc cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt      8700
caaagcaagt ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact      8760
atccttcgca agaccttcct ctatataagg aagttcattt catttggaga ggacacgctg      8820
aaatcaccag tctctctcta caaatctatc tctctcgagc tttcgcagat cccggggggc      8880
aatgagatat gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt ctgatcgaaa      8940
agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct cgtgctttca      9000
gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc gatggtttct      9060
acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt ccggaagtgc      9120
ttgacattgg ggagtttagc gagagcctga cctattgcat ctcccgccgt gcacagggtg      9180
tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctacaaccg gtcgcggagg      9240
ctatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc ccattcggac      9300
cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt gctgatcccc      9360
atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc gcgcaggctc      9420
tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc gtgcacgcgg      9480
atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc attgactgga      9540
gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc tggaggccgt      9600
ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg gagcttgcag      9660
gatcgccacg actccgggcg tatatgctcc gcattggtct tgaccaactc tatcagagct      9720
tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac gcaatcgtcc      9780
gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg gccgtctgga      9840
ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc actcgtccga      9900
gggcaaagaa atagagtaga tgccgaccgg atctgtcgat cgacaagctc gagtttctcc      9960
ataataatgt gtgagtagtt cccagataag ggaattaggg ttcctatagg gtttcgctca     10020
tgtgttgagc atataagaaa cccttagtat gtatttgtat ttgtaaaata cttctatcaa     10080
taaaatttct aattcctaaa accaaaatcc agtactaaaa tccagatccc ccgaattaat     10140
tcggcgttaa ttcagtacat taaaaacgtc cgcaatgtgt tattaagttg tctaagcgtc     10200
aatttgttta caccacaata tatcctgcca ccagccagcc aacagctccc cgaccggcag     10260
ctcggcacaa aatcaccact cgatacaggc agcccatcag tccgggacgg cgtcagcggg     10320
agagccgttg taaggcggca gactttgctc atgttaccga tgctattcgg aagaacggca     10380
actaagctgc cgggtttgaa acacggatga tctcgcggag ggtagcatgt tgattgtaac     10440
gatgacagag cgttgctgcc tgtgatcacc gcggtttcaa aatcggctcc gtcgatacta     10500
tgttatacgc caactttgaa aacaactttg aaaaagctgt tttctggtat ttaaggtttt     10560
agaatgcaag gaacagtgaa ttggagttcg tcttgttata attagcttct tggggtatct     10620
ttaaatactg tagaaaagag gaaggaaata ataaatggct aaaatgagaa tatcaccgga     10680
attgaaaaaa ctgatcgaaa aataccgctg cgtaaaagat acggaaggaa tgtctcctgc     10740
taaggtatat aagctggtgg gagaaaatga aaacctatat ttaaaaatga cggacagccg     10800
gtataaaggg accacctatg atgtggaacg ggaaaaggac atgatgctat ggctggaagg     10860
aaagctgcct gttccaaagg tcctgcactt tgaacggcat gatggctgga gcaatctgct     10920
catgagtgag gccgatggcg tcctttgctc ggaagagtat gaagatgaac aaagccctga     10980
aaagattatc gagctgtatg cggagtgcat caggctcttt cactccatcg acatatcgga     11040
ttgtccctat acgaatagct tagacagccg cttagccgaa ttggattact tactgaataa     11100
cgatctggcc gatgtggatt gcgaaaactg ggaagaagac actccattta aagatccgcg     11160
cgagctgtat gattttttaa agacggaaaa gcccgaagag gaacttgtct tttcccacgg     11220
cgacctggga gacagcaaca tctttgtgaa agatggcaaa gtaagtggct ttattgatct     11280
tgggagaagc ggcagggcgg acaagtggta tgacattgcc ttctgcgtcc ggtcgatcag     11340
ggaggatatc ggggaagaac agtatgtcga gctatttttt gacttactgg ggatcaagcc     11400
tgattgggag aaaataaaat attatatttt actggatgaa ttgttttagt acctagaatg     11460
catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     11520
gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     11580
aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     11640
gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta     11700
gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     11760
gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     11820
atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     11880
cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     11940
cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     12000
agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     12060
tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     12120
gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     12180
catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg     12240
agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc     12300
ggaagagcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat     12360
atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt atacactccg     12420
ctatcgctac gtgactgggt catggctgcg ccccgacacc cgccaacacc cgctgacgcg     12480
ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg     12540
agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca gggtgccttg     12600
atgtgggcgc cggcggtcga gtggcgacgg cgcggcttgt ccgcgccctg gtagattgcc     12660
tggccgtagg ccagccattt ttgagcggcc agcggccgcg ataggccgac gcgaagcggc     12720
ggggcgtagg gagcgcagcg accgaagggt aggcgctttt tgcagctctt cggctgtgcg     12780
ctggccagac agttatgcac aggccaggcg ggttttaaga gttttaataa gttttaaaga     12840
gttttaggcg gaaaaatcgc cttttttctc ttttatatca gtcacttaca tgtgtgaccg     12900
gttcccaatg tacggctttg ggttcccaat gtacgggttc cggttcccaa tgtacggctt     12960
tgggttccca atgtacgtgc tatccacagg aaacagacct tttcgacctt tttcccctgc     13020
tagggcaatt tgccctagca tctgctccgt acattaggaa ccggcggatg cttcgccctc     13080
gatcaggttg cggtagcgca tgactaggat cgggccagcc tgccccgcct cctccttcaa     13140
atcgtactcc ggcaggtcat ttgacccgat cagcttgcgc acggtgaaac agaacttctt     13200
gaactctccg gcgctgccac tgcgttcgta gatcgtcttg aacaaccatc tggcttctgc     13260
cttgcctgcg gcgcggcgtg ccaggcggta gagaaaacgg ccgatgccgg gatcgatcaa     13320
aaagtaatcg gggtgaaccg tcagcacgtc cgggttcttg ccttctgtga tctcgcggta     13380
catccaatca gctagctcga tctcgatgta ctccggccgc ccggtttcgc tctttacgat     13440
cttgtagcgg ctaatcaagg cttcaccctc ggataccgtc accaggcggc cgttcttggc     13500
cttcttcgta cgctgcatgg caacgtgcgt ggtgtttaac cgaatgcagg tttctaccag     13560
gtcgtctttc tgctttccgc catcggctcg ccggcagaac ttgagtacgt ccgcaacgtg     13620
tggacggaac acgcggccgg gcttgtctcc cttcccttcc cggtatcggt tcatggattc     13680
ggttagatgg gaaaccgcca tcagtaccag gtcgtaatcc cacacactgg ccatgccggc     13740
cggccctgcg gaaacctcta cgtgcccgtc tggaagctcg tagcggatca cctcgccagc     13800
tcgtcggtca cgcttcgaca gacggaaaac ggccacgtcc atgatgctgc gactatcgcg     13860
ggtgcccacg tcatagagca tcggaacgaa aaaatctggt tgctcgtcgc ccttgggcgg     13920
cttcctaatc gacggcgcac cggctgccgg cggttgccgg gattctttgc ggattcgatc     13980
agcggccgct tgccacgatt caccggggcg tgcttctgcc tcgatgcgtt gccgctgggc     14040
ggcctgcgcg gccttcaact tctccaccag gtcatcaccc agcgccgcgc cgatttgtac     14100
cgggccggat ggtttgcgac cgctcacgcc gattcctcgg gcttgggggt tccagtgcca     14160
ttgcagggcc ggcagacaac ccagccgctt acgcctggcc aaccgcccgt tcctccacac     14220
atggggcatt ccacggcgtc ggtgcctggt tgttcttgat tttccatgcc gcctccttta     14280
gccgctaaaa ttcatctact catttattca tttgctcatt tactctggta gctgcgcgat     14340
gtattcagat agcagctcgg taatggtctt gccttggcgt accgcgtaca tcttcagctt     14400
ggtgtgatcc tccgccggca actgaaagtt gacccgcttc atggctggcg tgtctgccag     14460
gctggccaac gttgcagcct tgctgctgcg tgcgctcgga cggccggcac ttagcgtgtt     14520
tgtgcttttg ctcattttct ctttacctca ttaactcaaa tgagttttga tttaatttca     14580
gcggccagcg cctggacctc gcgggcagcg tcgccctcgg gttctgattc aagaacggtt     14640
gtgccggcgg cggcagtgcc tgggtagctc acgcgctgcg tgatacggga ctcaagaatg     14700
ggcagctcgt acccggccag cgcctcggca acctcaccgc cgatgcgcgt gcctttgatc     14760
gcccgcgaca cgacaaaggc cgcttgtagc cttccatccg tgacctcaat gcgctgctta     14820
accagctcca ccaggtcggc ggtggcccat atgtcgtaag ggcttggctg caccggaatc     14880
agcacgaagt cggctgcctt gatcgcggac acagccaagt ccgccgcctg gggcgctccg     14940
tcgatcacta cgaagtcgcg ccggccgatg gccttcacgt cgcggtcaat cgtcgggcgg     15000
tcgatgccga caacggttag cggttgatct tcccgcacgg ccgcccaatc gcgggcactg     15060
ccctggggat cggaatcgac taacagaaca tcggccccgg cgagttgcag ggcgcgggct     15120
agatgggttg cgatggtcgt cttgcctgac ccgcctttct ggttaagtac agcgataacc     15180
ttcatgcgtt ccccttgcgt atttgtttat ttactcatcg catcatatac gcagcgaccg     15240
catgacgcaa gctgttttac tcaaatacac atcacctttt tagacggcgg cgctcggttt     15300
cttcagcggc caagctggcc ggccaggccg ccagcttggc atcagacaaa ccggccagga     15360
tttcatgcag ccgcacggtt gagacgtgcg cgggcggctc gaacacgtac ccggccgcga     15420
tcatctccgc ctcgatctct tcggtaatga aaaacggttc gtcctggccg tcctggtgcg     15480
gtttcatgct tgttcctctt ggcgttcatt ctcggcggcc gccagggcgt cggcctcggt     15540
caatgcgtcc tcacggaagg caccgcgccg cctggcctcg gtgggcgtca cttcctcgct     15600
gcgctcaagt gcgcggtaca gggtcgagcg atgcacgcca agcagtgcag ccgcctcttt     15660
cacggtgcgg ccttcctggt cgatcagctc gcgggcgtgc gcgatctgtg ccggggtgag     15720
ggtagggcgg gggccaaact tcacgcctcg ggccttggcg gcctcgcgcc cgctccgggt     15780
gcggtcgatg attagggaac gctcgaactc ggcaatgccg gcgaacacgg tcaacaccat     15840
gcggccggcc ggcgtggtgg tgtcggccca cggctctgcc aggctacgca ggcccgcgcc     15900
ggcctcctgg atgcgctcgg caatgtccag taggtcgcgg gtgctgcggg ccaggcggtc     15960
tagcctggtc actgtcacaa cgtcgccagg gcgtaggtgg tcaagcatcc tggccagctc     16020
cgggcggtcg cgcctggtgc cggtgatctt ctcggaaaac agcttggtgc agccggccgc     16080
gtgcagttcg gcccgttggt tggtcaagtc ctggtcgtcg gtgctgacgc gggcatagcc     16140
cagcaggcca gcggcggcgc tcttgttcat ggcgtaatgt ctccggttct agtcgcaagt     16200
attctacttt atgcgactaa aacacgcgac aagaaaacgc caggaaaagg gcagggcggc     16260
agcctgtcgc gtaacttagg acttgtgcga catgtcgttt tcagaagacg gctgcactga     16320
acgtcagaag ccgactgcac tatagcagcg gaggggttgg atcaaagtac tttgatcccg     16380
aggggaaccc tgtggttggc atgcacatac aaatggacga acggataaac cttttcacgc     16440
ccttttaaat atccgttatt ctaataaacg ctcttttctc ttag                      16484

