                         SEQUENCE LISTING

<110>  aTyr Pharma, Inc.
       Burman, Luke
       Chong, Yee Ting 
       Gang, Yanyan
       Green, Leslie Nangle
       Hamel, Kristina
       King, David
       Menefee, Ann
       Rauch, Kaitlyn
       Xu, Zhiwen
       Zhao, Liting
 
<120>  COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2 ANTIBODIES

<130>  ATYR-134/01WO 315789-2761

<150>  US 62/653,823
<151>  2018-04-06

<160>  128   

<170>  PatentIn version 3.5

<210>  1
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  2
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  3
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210>  4
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  5
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  6
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210>  7
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp 
785                 790                 795                 800 


Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala 
                805                 810                 815     


Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu 
            820                 825                 830         


Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu 
        835                 840                 845             


Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr 
    850                 855                 860                 


Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn 
865                 870                 875                 880 


Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn 
                885                 890                 895     


His Gln Lys Cys Cys Ser Glu Ala 
            900                 


<210>  8
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr 
785                 790                 795                 800 


Val Pro Met Gln Pro Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala 
                805                 810                 815     


Gly Gly Ala Val Leu Val Leu Val Ser Val Ala Leu Ala Leu Val Leu 
            820                 825                 830         


His Tyr His Arg Phe Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile 
        835                 840                 845             


Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu 
    850                 855                 860                 


Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
865                 870                 875                 


<210>  9
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Val Gly Cys 
        515                 520                 525             


Ser Trp Arg Pro Leu 
    530             


<210>  10
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro 
1               5                   10                  15      


Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val 
            20                  25                  30          


Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His 
        35                  40                  45              


Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg 
    50                  55                  60                  


Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn 
65                  70                  75                  80  


Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys 
                85                  90                  95      


Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr 
            100                 105                 110         


Glu Ile 
        


<210>  11
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu 
            20                  25                  30          


Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu 
        35                  40                  45              


Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp 
    50                  55                  60                  


Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys 
65                  70                  75                  80  


Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile 
                85                  90                  95      


Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe 
            100                 105                 110         


Ser Ala Arg Tyr Tyr 
        115         


<210>  12
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser Ala 
1               5                   10                  15      


Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg Leu 
            20                  25                  30          


His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys Glu 
        35                  40                  45              


Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile Ala 
    50                  55                  60                  


Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val Lys 
65                  70                  75                  80  


Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val Tyr 
                85                  90                  95      


Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala Thr 
            100                 105                 110         


Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe Val 
        115                 120                 125             


Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu Glu 
    130                 135                 140                 


Leu Phe Gly 
145         


<210>  13
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser 
1               5                   10                  15      


Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser 
            20                  25                  30          


Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu 
        35                  40                  45              


Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val 
    50                  55                  60                  


Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala 
65                  70                  75                  80  


Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys 
                85                  90                  95      


Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe 
            100                 105                 110         


Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro 
        115                 120                 125             


Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala 
    130                 135                 140                 


Gly Ile Gly Met Arg Leu Glu Val Leu Gly 
145                 150                 


<210>  14
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
1               5                   10                  15      


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            20                  25                  30          


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        35                  40                  45              


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    50                  55                  60                  


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
65                  70                  75                  80  


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                85                  90                  95      


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            100                 105                 110         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        115                 120                 125             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    130                 135                 140                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp 
145                 150                 


<210>  15
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr 
            


<210>  16
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu 
            20                  25                  30          


Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu 
        35                  40                  45              


Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp 
    50                  55                  60                  


Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys 
65                  70                  75                  80  


Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile 
                85                  90                  95      


Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe 
            100                 105                 110         


Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln 
        115                 120                 125             


Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln 
    130                 135                 140                 


Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln 
145                 150                 155                 160 


Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser 
                165                 170                 175     


Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr 
            180                 185                 190         


Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr 
        195                 200                 205             


Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp 
    210                 215                 220                 


Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn 
225                 230                 235                 240 


Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr 
                245                 250                 255     


Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu 
            260                 265                 270         


Arg Leu Glu Leu Phe Gly 
        275             


<210>  17
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly 
                


<210>  18
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
                565                 570             


<210>  19
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
1               5                   10                  15      


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
            20                  25                  30          


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
        35                  40                  45              


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
    50                  55                  60                  


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
65                  70                  75                  80  


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
                85                  90                  95      


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
            100                 105                 110         


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
        115                 120                 125             


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
    130                 135                 140                 


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
145                 150                 155                 160 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
                165                 170                 175     


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
            180                 185                 190         


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
        195                 200                 205             


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
    210                 215                 220                 


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
225                 230                 235                 240 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
                245                 250                 255     


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
            260                 265                 270         


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
        275                 280                 285             


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
    290                 295                 300                 


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
305                 310                 315                 320 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
                325                 330                 335     


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
            340                 345                 350         


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
        355                 360                 365             


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
    370                 375                 380                 


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
385                 390                 395                 400 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
                405                 410                 415     


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
            420                 425                 430         


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
        435                 440                 445             


Asp Trp Thr 
    450     


<210>  20
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu 
1               5                   10                  15      


Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln 
            20                  25                  30          


Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp 
        35                  40                  45              


Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu 
    50                  55                  60                  


Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly 
65                  70                  75                  80  


Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp 
                85                  90                  95      


Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn 
            100                 105                 110         


Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu 
        115                 120                 125             


Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala 
    130                 135                 140                 


Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser 
145                 150                 155                 160 


Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser 
                165                 170                 175     


Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu 
            180                 185                 190         


Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro 
        195                 200                 205             


Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys 
    210                 215                 220                 


Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val 
225                 230                 235                 240 


Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn 
                245                 250                 255     


Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys 
            260                 265                 270         


Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe 
        275                 280                 285             


Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser 
    290                 295                 300                 


Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
305                 310                 315                 320 


<210>  21
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized construct - NRP2 v2 - Fc fusion protein

<400>  21

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp 
785                 790                 795                 800 


Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala 
                805                 810                 815     


Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu 
            820                 825                 830         


Tyr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        835                 840                 845             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    850                 855                 860                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
865                 870                 875                 880 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                885                 890                 895     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            900                 905                 910         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        915                 920                 925             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    930                 935                 940                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
945                 950                 955                 960 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                965                 970                 975     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            980                 985                 990         


Glu Trp Glu Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
        995                 1000                 1005             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
    1010                 1015                 1020             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1025                 1030                 1035             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1040                 1045                 1050             


Leu Ser  Leu Ser Pro Gly Lys  
    1055                 1060 


<210>  22
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized construct  - NRP2 A2B1B2-Fc

<400>  22

Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
1               5                   10                  15      


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
            20                  25                  30          


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
        35                  40                  45              


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
    50                  55                  60                  


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
65                  70                  75                  80  


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
                85                  90                  95      


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
            100                 105                 110         


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
        115                 120                 125             


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
    130                 135                 140                 


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
145                 150                 155                 160 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
                165                 170                 175     


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
            180                 185                 190         


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
        195                 200                 205             


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
    210                 215                 220                 


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
225                 230                 235                 240 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
                245                 250                 255     


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
            260                 265                 270         


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
        275                 280                 285             


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
    290                 295                 300                 


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
305                 310                 315                 320 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
                325                 330                 335     


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
            340                 345                 350         


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
        355                 360                 365             


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
    370                 375                 380                 


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
385                 390                 395                 400 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
                405                 410                 415     


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
            420                 425                 430         


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
        435                 440                 445             


Asp Trp Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    450                 455                 460                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
465                 470                 475                 480 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                485                 490                 495     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            500                 505                 510         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        515                 520                 525             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    530                 535                 540                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
545                 550                 555                 560 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                565                 570                 575     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            580                 585                 590         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        595                 600                 605             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    610                 615                 620                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
625                 630                 635                 640 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                645                 650                 655     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            660                 665                 670         


Ser Leu Ser Pro Gly Lys 
        675             


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VH CDR1

<400>  23

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VH CDR2

<400>  24

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Gln Phe Lys 
1               5                   10                  15      


Gly Lys Ala 
            


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VH CDR3

<400>  25

Arg Gly Gly Gly Tyr Phe Asp Tyr 
1               5               


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VL CDR1

<400>  26

Lys Ala Ser Gln Asn Val Gly Ala Ala Val Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VL CDR2

<400>  27

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-1 VL CDR3

<400>  28

Gln Gln Tyr Ser Ser Tyr Pro Leu Leu Thr 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VH CDR1

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VH CDR2

<400>  30

Val Ile His Pro Asn Ser Ala Ser Thr Phe Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VH CDR3

<400>  31

Pro Gly Thr Val Arg Arg Ser Asp Tyr 
1               5                   


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VL CDR1

<400>  32

Arg Ser Ser Gln Asn Ile Val His Ser Thr Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VL CDR2

<400>  33

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-2 VL CDR3

<400>  34

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VH CDR1

<400>  35

Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His 
1               5                   10  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VH CDR2

<400>  36

Arg Ile Asp Val Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VH CDR3

<400>  37

Pro Ile Tyr Gly Ser Arg Glu Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VL CDR1

<400>  38

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VL CDR2

<400>  39

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-6 VL CDR3

<400>  40

His Gln Tyr Tyr Arg Ser Pro Pro Thr 
1               5                   


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VH CDR1

<400>  41

Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VH CDR2

<400>  42

Arg Ile Asp Val Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VH CDR3

<400>  43

Pro Ile Tyr Gly Ser Arg Glu Ala Phe Phe Ala Tyr 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VL CDR1

<400>  44

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VL CDR2

<400>  45

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-7 VL CDR3

<400>  46

His Gln Tyr Tyr Arg Ser Pro Pro Thr 
1               5                   


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VH CDR1

<400>  47

Gly Phe Asn Val Lys Asp Tyr Tyr Val His 
1               5                   10  


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VH CDR2

<400>  48

Arg Ile Asp Val Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VH CDR3

<400>  49

Pro Ile Tyr Gly Ala Arg Glu Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VL CDR1

<400>  50

Thr Ala Asn Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VL CDR2

<400>  51

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-8 VL CDR3

<400>  52

His Gln Tyr His Arg Ser Pro Pro Thr 
1               5                   


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VH CDR1

<400>  53

Gly Phe Ser Leu Thr Asn Tyr Gly Val Tyr 
1               5                   10  


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VH CDR2

<400>  54

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VH CDR3

<400>  55

Asn Gly Pro Asn Trp Asp Arg Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VL CDR1

<400>  56

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VL CDR2

<400>  57

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-9 VL CDR3

<400>  58

Gln Gln His Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VH CDR1

<400>  59

Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His 
1               5                   10  


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VH CDR2

<400>  60

Arg Ile Asp Val Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VH CDR3

<400>  61

Pro Ile Tyr Gly Ser Arg Glu Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VL CDR1

<400>  62

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VL CDR2

<400>  63

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-10 VL CDR3

<400>  64

His Gln Tyr Tyr Arg Ser Pro Pro Thr 
1               5                   


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VH CDR1

<400>  65

Gly Tyr Thr Phe Thr Ser Phe Gly Ile Ser 
1               5                   10  


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VH CDR2

<400>  66

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VH CDR3

<400>  67

Ser Ser Gly Tyr Tyr Gly Ser Thr Pro Phe Pro Tyr 
1               5                   10          


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VL CDR1

<400>  68

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VL CDR2

<400>  69

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-11 VL CDR3

<400>  70

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VH CDR1

<400>  71

Gly Tyr Thr Phe Thr Thr Ser Gly Met Ser 
1               5                   10  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VH CDR2

<400>  72

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VH CDR3

<400>  73

Tyr Tyr Ser Tyr Tyr Val Asp Phe Asp Tyr 
1               5                   10  


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VL CDR1

<400>  74

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VL CDR2

<400>  75

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-12 VL CDR3

<400>  76

His Gln Trp Ser Ser Tyr Pro Arg Thr 
1               5                   


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VH CDR1

<400>  77

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VH CDR2

<400>  78

Leu Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ser Pro Ala Phe Ile Ser 
1               5                   10                  15      


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VH CDR3

<400>  79

Asn Ser Tyr Ser Ser Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VL CDR1

<400>  80

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VL CDR2

<400>  81

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-14 VL CDR3

<400>  82

Gln Gln Tyr Ser Ser Tyr Pro Pro Tyr Thr 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VH CDR1

<400>  83

Gly Phe Asn Ile Lys Asp Ser Phe Ile His 
1               5                   10  


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VH CDR2

<400>  84

Arg Ile Asp Pro Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VH CDR3

<400>  85

Pro Ile Tyr Gly Ser Arg Glu Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VL CDR1

<400>  86

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VL CDR2

<400>  87

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized  aNRP2-15 VL CDR3

<400>  88

His Gln Tyr Tyr Arg Ser Pro Pro Thr 
1               5                   


<210>  89
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  89

Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser 
1               5                   10                  15      


Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser 
            20                  25                  30          


Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu 
        35                  40                  45              


Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val 
    50                  55                  60                  


Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala 
65                  70                  75                  80  


Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys 
                85                  90                  95      


Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe 
            100                 105                 110         


Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro 
        115                 120                 125             


Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala 
    130                 135                 140                 


Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser 
145                 150                 155                 160 


Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr 
                165                 170                 175     


Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn 
            180                 185                 190         


Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn 
        195                 200                 205             


Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His 
    210                 215                 220                 


Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp 
225                 230                 235                 240 


Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser 
                245                 250                 255     


Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu 
            260                 265                 270         


Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly 
        275                 280                 285             


Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys 
    290                 295                 300                 


Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly 
305                 310                 315                 320 


Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu 
                325                 330                 335     


Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile 
            340                 345                 350         


Arg Ile Ser Thr Asp 
        355         


<210>  90
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  90

Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu 
1               5                   10                  15      


Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln 
            20                  25                  30          


Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp 
        35                  40                  45              


Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu 
    50                  55                  60                  


Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly 
65                  70                  75                  80  


Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp 
                85                  90                  95      


Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn 
            100                 105                 110         


Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu 
        115                 120                 125             


Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala 
    130                 135                 140                 


Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser 
145                 150                 155                 160 


Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser 
                165                 170                 175     


Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu 
            180                 185                 190         


Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro 
        195                 200                 205             


Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys 
    210                 215                 220                 


Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val 
225                 230                 235                 240 


Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn 
                245                 250                 255     


Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys 
            260                 265                 270         


Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe 
        275                 280                 285             


Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser 
    290                 295                 300                 


Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
305                 310                 315                 320 


Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu 
                325                 330                 335     


Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly 
            340                 345                 350         


Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly 
        355                 360                 365             


Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr 
    370                 375                 380                 


Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro 
385                 390                 395                 400 


Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser 
                405                 410                 415     


Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val 
            420                 425                 430         


His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr 
        435                 440                 445             


Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu 
    450                 455                 460                 


Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys 
465                 470                 475                 480 


His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val 
                485                 490                 495     


Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp 
            500                 505                 510         


Asp Ile Arg Ile Ser Thr Asp 
        515                 


<210>  91
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  92
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met 
    130                 135                 140     


<210>  93
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu 
                405             


<210>  94
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu 
    


<210>  95
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  96
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg Ile Leu 
                245                 250                 255     


Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr 
            260                 265                 270 


<210>  97
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
1               5                   10                  15      


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
            20                  25                  30          


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
        35                  40                  45              


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
    50                  55                  60                  


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
65                  70                  75                  80  


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
                85                  90                  95      


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            100                 105 


<210>  98
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile 
    50                  55                  60                  


Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile 
65                  70                  75                  80  


Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys 
                85                  90                  95      


Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
            100                 105                 110         


Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp 
        115                 120                 125             


Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly 
    130                 135                 140                 


Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His 
145                 150                 155                 160 


Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser 
                165                 170                 175     


Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe 
            180                 185                 190         


Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu 
        195                 200                 205             


Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala 
    210                 215                 220                 


Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val 
225                 230                 235                 240 


Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe 
                245                 250                 255     


Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val 
            260                 265                 270         


Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
    290                 295                 300                 


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
305                 310                 315                 320 


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
                325                 330                 335     


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
            340                 345                 350         


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
        355                 360                 365             


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
    370                 375                 380                 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395 


<210>  99
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            100                 105                 110         


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        115                 120                 125             


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    130                 135                 140                 


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
145                 150                 155                 160 


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                165                 170                 175     


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            180                 185                 190         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        195                 200                 205             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val 
    210                 215                 220                 


Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu 
                245                 250                 255     


Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu 
            260                 265                 270         


Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu 
        275                 280                 285             


Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala 
    290                 295                 300                 


Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu 
305                 310                 315                 320 


Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro 
                325                 330                 335     


Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu 
            340                 345                 350         


Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu 
        355                 360                 365             


Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu 
    370                 375                 380                 


Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395                 


<210>  100
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn 
                165                 170                 175     


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp 
            180                 185                 190         


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val 
        195                 200                 205             


Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala 
    210                 215                 220                 


Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly 
225                 230                 235                 240 


Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
                245                 250                 255     


Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr 
            260                 265                 270         


Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu 
        275                 280                 285             


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
    290                 295                 300                 


Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser 
305                 310                 315                 320 


Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro 
                325                 330                 335     


Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg 
            340                 345                 350         


Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile 
        355                 360                 365             


Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
    370                 375                 380                 


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
385                 390                 395                 400 


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
                405                 410                 415     


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
            420                 425                 430         


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
        435                 440                 445             


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
    450                 455                 460                 


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
465                 470             


<210>  101
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met 
    50                  55                  60                  


Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln 
65                  70                  75                  80  


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
                85                  90                  95      


Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile 
            100                 105                 110         


Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr 
        115                 120                 125             


Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro 
    130                 135                 140                 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
145                 150                 155                 160 


Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile 
                165                 170                 175     


Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg 
            180                 185                 190         


Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu 
        195                 200                 205             


Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala 
    210                 215                 220                 


Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val 
225                 230                 235                 240 


Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu 
                245                 250                 255     


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
            260                 265                 270         


Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
        275                 280                 285             


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
    290                 295                 300                 


Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly 
305                 310                 315                 320 


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys 
                325                 330                 335     


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
            340                 345                 350         


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu 
        355                 360                 365             


Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg 
    370                 375                 380                 


Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu 
385                 390                 395                 400 


Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu 
                405                 410                 415     


Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            420                 425                 430         


Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp 
        435                 440                 445             


Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln 
    450                 455                 460                 


Pro Leu Cys Ile Cys 
465                 


<210>  102
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            100                 105                 110         


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu 
        115                 120                 125             


Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp 
    130                 135                 140                 


Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile 
145                 150                 155                 160 


Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys 
                165                 170                 175     


Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
            180                 185                 190         


Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln 
        195                 200                 205             


Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
    210                 215                 220                 


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
225                 230                 235                 240 


Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
                245                 250                 255     


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln 
            260                 265                 270         


Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg 
        275                 280                 285             


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro 
    290                 295                 300                 


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu 
305                 310                 315                 320 


Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
                325                 330                 335     


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
            340                 345                 350         


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
        355                 360                 365             


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
    370                 375                 380                 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
385                 390                 395                 400 


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
                405                 410                 415     


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            420                 425                 430         


Cys Ile Cys 
        435 


<210>  103
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu 
    50                  55                  60                  


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
65                  70                  75                  80  


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
                85                  90                  95      


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
            100                 105                 110         


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
        115                 120                 125             


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
    130                 135                 140                 


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
145                 150                 155                 160 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
                165                 170     


<210>  104
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
            100                 105                 110         


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
        115                 120                 125             


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
    130                 135                 140                 


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
145                 150                 155                 160 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
                165                 170                 175     


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
            180                 185                 190         


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Cys Ile Cys 
    210     


<210>  105
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
1               5                   10                  15      


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
            20                  25                  30          


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
        35                  40                  45              


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
    50                  55                  60                  


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
                85                  90                  95      


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
            100                 105                 110         


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
        115                 120                 125             


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
    130                 135                 140     


<210>  106
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  106

Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp 
1               5                   10                  15      


Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            20                  25                  30          


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        35                  40                  45              


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    50                  55                  60                  


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
65                  70                  75                  80  


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                85                  90                  95      


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            100                 105                 110         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        115                 120                 125             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly 
    130                 135                 140             


<210>  107
<211>  506
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(506)
<223>  Mitochondrial

<400>  107

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  108
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  108

His Val Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly 
1               5                   10                  15      


Arg Tyr Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe 
            20                  25                  30          


Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile 
        35                  40                  45              


Leu Ser Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp Arg 
    50                  55                  60                  


Arg Ile Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser Lys 
65                  70                  75                  80  


Phe Arg Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala Trp 
                85                  90                  95      


Lys Asp Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu 
            100                 105                 110         


Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser 
        115                 120                 125             


Leu Val Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln 
    130                 135                 140                 


Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr 
145                 150                 155                 160 


Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg 
                165                 170                 175     


Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln 
            180                 185                 190         


Thr Pro Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala 
        195                 200                 205             


Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly 
    210                 215                 220                 


His Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe 
225                 230                 235                 240 


Tyr Ile Val Glu Gln Arg Met 
                245         


<210>  109
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  109

Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
1               5                   10                  15      


Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
        35                  40                  45              


Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val 
    50                  55                  60                  


Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro 
65                  70                  75                  


<210>  110
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  110

Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
1               5                   10                  15      


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys 
            20                  25                  30          


Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu 
        35                  40                  45              


Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu 
    50                  55                  60                  


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
65                  70                  75                  80  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg 
                85                  90                  95      


Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg 
            100                 105                 110         


Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn 
        115                 120                 125             


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
    130                 135                 140                 


Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp 
145                 150                 155                 160 


Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser 
                165                 170                 175     


Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser 
            180                 185                 190         


Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro 
        195                 200                 205             


Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val 
    210                 215                 220                 


Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys 
225                 230                 235                 240 


Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
                245                 250                 255     


Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
            260                 265                 270         


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
        275                 280                 285             


Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val 
    290                 295                 300                 


Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
305                 310                 315                 320 


Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile 
                325                 330                 335     


Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg 
            340                 345                 350         


Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu 
        355                 360                 365             


Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys 
    370                 375                 380                 


Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln 
385                 390                 395                 400 


Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln 
                405                 410                 415     


Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu 
            420                 425                 430         


Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg 
        435                 440                 445             


Thr Gly Gln Pro Leu Cys Ile Cys 
    450                 455     


<210>  111
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  111

Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
1               5                   10                  15      


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys 
            20                  25                  30          


Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu 
        35                  40                  45              


Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu 
    50                  55                  60                  


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
65                  70                  75                  80  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg 
                85                  90                  95      


Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg 
            100                 105                 110         


Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn 
        115                 120                 125             


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
    130                 135                 140                 


Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp 
145                 150                 155                 160 


Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser 
                165                 170                 175     


Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser 
            180                 185                 190         


Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro 
        195                 200                 205             


Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val 
    210                 215                 220                 


Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys 
225                 230                 235                 240 


Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
                245                 250                 255     


Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
            260                 265                 270         


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
        275                 280                 285             


Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val 
    290                 295                 300                 


Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
305                 310                 315                 320 


Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile 
                325                 330                 335     


Phe Ser Ile Val Glu Gln Arg Leu Glu 
            340                 345 


<210>  112
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  112

Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
1               5                   10                  15      


Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile 
            20                  25                  30          


Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly 
        35                  40                  45              


Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu 
    50                  55                  60                  


Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala 
65                  70                  75                  80  


Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr 
                85                  90                  95      


Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr 
            100                 105                 110         


Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp 
        115                 120                 125             


Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile 
    130                 135                 140                 


Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met 
145                 150                 155                 160 


Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser 
                165                 170                 175     


Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu 
            180                 185                 190         


Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly 
        195                 200                 205             


Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu 
    210                 215                 220                 


Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly 
225                 230                 235                 240 


Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp 
                245                 250                 255     


Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr 
            260                 265                 270         


Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly 
        275                 280                 285             


Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp 
    290                 295                 300                 


Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val 
305                 310                 315                 320 


Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg 
                325                 330                 335     


Leu Glu 
        


<210>  113
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala 
1               5                   10                  15      


Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu 
            20                  25                  30          


Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro 
        35                  40                  45              


Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu 
    50                  55                  60                  


Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu 
65                  70                  75                  80  


Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu 
                85                  90                  95      


Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            100                 105                 110     


<210>  114
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  114

Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu 
1               5                   10                  15      


Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys 
            20                  25                  30          


Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln 
        35                  40                  45              


Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln 
    50                  55                  60                  


Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu 
65                  70                  75                  80  


Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg 
                85                  90                  95      


<210>  115
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus HRS WHEP sequence


<220>
<221>  MOD_RES
<222>  (1)..(50)
<223>  Xaa is any amino acid or absent

<220>
<221>  misc_feature
<222>  (52)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (57)..(58)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (61)..(62)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (65)..(65)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (68)..(69)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (72)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (79)..(80)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (82)..(83)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (86)..(86)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (89)..(138)
<223>  Xaa is any amino acid or absent

<400>  115

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gly Xaa Xaa Val Arg 
    50                  55                  60                  


Xaa Leu Lys Xaa Xaa Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Val Xaa Xaa Leu Leu Xaa Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135             


<210>  116
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  116

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  117
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized IgG4 variant

<400>  117

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  118
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  118

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  119
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  119

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  120
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized construct - NRP2 (23-595 Fc fusion protein

<400>  120

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Lys Thr 
                565                 570                 575     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            580                 585                 590         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        595                 600                 605             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    610                 615                 620                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
625                 630                 635                 640 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                645                 650                 655     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            660                 665                 670         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        675                 680                 685             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    690                 695                 700                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
705                 710                 715                 720 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                725                 730                 735     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            740                 745                 750         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        755                 760                 765             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    770                 775                 780                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
785                 790                 795                 800 


<210>  121
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  121

Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu 
            20                  25                  30          


Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu 
        35                  40                  45              


Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp 
    50                  55                  60                  


Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys 
65                  70                  75                  80  


Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile 
                85                  90                  95      


Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe 
            100                 105                 110         


Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln 
        115                 120                 125             


Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln 
    130                 135                 140                 


Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln 
145                 150                 155                 160 


Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser 
                165                 170                 175     


Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr 
            180                 185                 190         


Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr 
        195                 200                 205             


Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp 
    210                 215                 220                 


Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn 
225                 230                 235                 240 


Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr 
                245                 250                 255     


Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu 
            260                 265                 270         


Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn 
        275                 280                 285             


Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala 
    290                 295                 300                 


Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val 
305                 310                 315                 320 


Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly 
                325                 330                 335     


Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly 
            340                 345                 350         


Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu 
        355                 360                 365             


Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly 
    370                 375                 380                 


Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu 
385                 390                 395                 400 


Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp 
                405                 410                 415     


Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro 
            420                 425                 430         


Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp 
        435                 440                 445             


Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu 
    450                 455                 460                 


Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu 
465                 470                 475                 480 


Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe 
                485                 490                 495     


Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp 
            500                 505                 510         


His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn 
        515                 520                 525             


Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp 
    530                 535                 540                 


Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His 
545                 550                 555                 560 


Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly 
                565                 570                 575     


Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser 
            580                 585                 590         


Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His 
        595                 600                 605             


Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe 
    610                 615                 620                 


Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp 
625                 630                 635                 640 


Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu 
                645                 650                 


<210>  122
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  122

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu 
    770                 775                 780 


<210>  123
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  123

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp 
785                 790                 795                 800 


Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala 
                805                 810                 815     


Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu 
            820                 825                 830         


Tyr Thr Leu Asp Pro 
        835         


<210>  124
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr 
785                 790                 795                 800 


Val Pro Met Gln Pro Ile Pro Ala Tyr 
                805                 


<210>  125
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Primer

<400>  125
tgaggatgac aaagatttgc agct                                              24


<210>  126
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Primer

<400>  126
accgcggccg gccgtttatg cctcggagca gcactt                                 36


<210>  127
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Primer

<400>  127
agtgccaagc aagcaactca aa                                                22


<210>  128
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Primer

<400>  128
aagtgctgct ccgaggcata aacggccggc cgcggt                                 36


