                         SEQUENCE LISTING

<110>  NightstaRx Limited
 
<120>  AAV COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE

<130>  NIGH-013/001WO

<150>  US 62/653,139
<151>  2018-04-05

<150>  US 62/746,980
<151>  2018-10-17

<150>  US 62/773,975
<151>  2018-11-30

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1992
<212>  DNA
<213>  Homo sapiens


<220>
<221>  REP1 gene
<222>  (1)..(1992)

<400>  1
gatatcgaat tcctgcagcc cggcggcacc atggcggata ctctcccttc ggagtttgat       60

gtgatcgtaa tagggacggg tttgcctgaa tccatcattg cagctgcatg ttcaagaagt      120

ggccggagag ttctgcatgt tgattcaaga agctactatg gaggaaactg ggccagtttt      180

agcttttcag gactattgtc ctggctaaag gaataccagg aaaacagtga cattgtaagt      240

gacagtccag tgtggcaaga ccagatcctt gaaaatgaag aagccattgc tcttagcagg      300

aaggacaaaa ctattcaaca tgtggaagta ttttgttatg ccagtcagga tttgcatgaa      360

gatgtcgaag aagctggtgc actgcagaaa aatcatgctc ttgtgacatc tgcaaactcc      420

acagaagctg cagattctgc cttcctgcct acggaggatg agtcattaag cactatgagc      480

tgtgaaatgc tcacagaaca aactccaagc agcgatccag agaatgcgct agaagtaaat      540

ggtgctgaag tgacagggga aaaagaaaac cattgtgatg ataaaacttg tgtgccatca      600

acttcagcag aagacatgag tgaaaatgtg cctatagcag aagataccac agagcaacca      660

aagaaaaaca gaattactta ctcacaaatt attaaagaag gcaggagatt taatattgat      720

ttagtatcaa agctgctgta ttctcgagga ttactaattg atcttctaat caaatctaat      780

gttagtcgat atgcagagtt taaaaatatt accaggattc ttgcatttcg agaaggacga      840

gtggaacagg ttccgtgttc cagagcagat gtctttaata gcaaacaact tactatggta      900

gaaaagcgaa tgctaatgaa atttcttaca ttttgtatgg aatatgagaa atatcctgat      960

gaatataaag gatatgaaga gatcacattt tatgaatatt taaagactca aaaattaacc     1020

cccaacctcc aatatattgt catgcattca attgcaatga catcagagac agccagcagc     1080

accatagatg gtctcaaagc taccaaaaac tttcttcact gtcttgggcg gtatggcaac     1140

actccatttt tgtttccttt atatggccaa ggagaactcc cccagtgttt ctgcaggatg     1200

tgtgctgtgt ttggtggaat ttattgtctt cgccattcag tacagtgcct tgtagtggac     1260

aaagaatcca gaaaatgtaa agcaattata gatcagtttg gtcagagaat aatctctgag     1320

catttcctcg tggaggacag ttactttcct gagaacatgt gctcacgtgt gcaatacagg     1380

cagatctcca gggcagtgct gattacagat agatctgtcc taaaaacaga ttcagatcaa     1440

cagatttcca ttttgacagt gccagcagag gaaccaggaa cttttgctgt tcgggtcatt     1500

gagttatgtt cttcaacgat gacatgcatg aaaggcacct atttggttca tttgacttgc     1560

acatcttcta aaacagcaag agaagattta gaatcagttg tgcagaaatt gtttgttcca     1620

tatactgaaa tggagataga aaatgaacaa gtagaaaagc caagaattct gtgggctctt     1680

tacttcaata tgagagattc gtcagacatc agcaggagct gttataatga tttaccatcc     1740

aacgtttatg tctgctctgg cccagattgt ggtttaggaa atgataatgc agtcaaacag     1800

gctgaaacac ttttccagga aatctgcccc aatgaagatt tctgtccccc tccaccaaat     1860

cctgaagaca ttatccttga tggagacagt ttacagccag aggcttcaga atccagtgcc     1920

ataccagagg ctaactcgga gactttcaag gaaagcacaa accttggaaa cctagaggag     1980

tcctctgaat aa                                                         1992


<210>  2
<211>  653
<212>  PRT
<213>  Homo sapiens


<220>
<221>  REP1 protein
<222>  (1)..(653)

<400>  2

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  3
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  3
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg       60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      240

taccatgg                                                               248


<210>  4
<211>  250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  4
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg                                                             250


<210>  5
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  5
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg cgctgccttc      300

gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt      360

tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg      420

tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg      480

gccctttgtg cggggggagc ggctcgggg                                        509


<210>  6
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  6
ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt       60

tattgtgctg tctcatcatt ttggcaaaga att                                    93


<210>  7
<211>  691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  7
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg cgctgccttc      300

gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt      360

tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg      420

tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg      480

gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg ccttcggggg      540

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct      600

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg      660

ctgtctcatc attttggcaa agaattggat c                                     691


<210>  8
<211>  941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  8
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga      600

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat      660

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg      720

ctccgggagg gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg      780

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag      840

agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct      900

ggttattgtg ctgtctcatc attttggcaa agaattggat c                          941


<210>  9
<211>  1992
<212>  DNA
<213>  Homo sapiens

<400>  9
gatatcgaat tcctgcagcc cggcggcacc atggcggata ctctcccttc ggagtttgat       60

gtgatcgtaa tagggacggg tttgcctgaa tccatcattg cagctgcatg ttcaagaagt      120

ggccggagag ttctgcatgt tgattcaaga agctactatg gaggaaactg ggccagtttt      180

agcttttcag gactattgtc ctggctaaag gaataccagg aaaacagtga cattgtaagt      240

gacagtccag tgtggcaaga ccagatcctt gaaaatgaag aagccattgc tcttagcagg      300

aaggacaaaa ctattcaaca tgtggaagta ttttgttatg ccagtcagga tttgcatgaa      360

gatgtcgaag aagctggtgc actgcagaaa aatcatgctc ttgtgacatc tgcaaactcc      420

acagaagctg cagattctgc cttcctgcct acggaggatg agtcattaag cactatgagc      480

tgtgaaatgc tcacagaaca aactccaagc agcgatccag agaatgcgct agaagtaaat      540

ggtgctgaag tgacagggga aaaagaaaac cattgtgatg ataaaacttg tgtgccatca      600

acttcagcag aagacatgag tgaaaatgtg cctatagcag aagataccac agagcaacca      660

aagaaaaaca gaattactta ctcacaaatt attaaagaag gcaggagatt taatattgat      720

ttagtatcaa agctgctgta ttctcgagga ttactaattg atcttctaat caaatctaat      780

gttagtcgat atgcagagtt taaaaatatt accaggattc ttgcatttcg agaaggacga      840

gtggaacagg ttccgtgttc cagagcagat gtctttaata gcaaacaact tactatggta      900

gaaaagcgaa tgctaatgaa atttcttaca ttttgtatgg aatatgagaa atatcctgat      960

gaatataaag gatatgaaga gatcacattt tatgaatatt taaagactca aaaattaacc     1020

cccaacctcc aatatattgt catgcattca attgcaatga catcagagac agccagcagc     1080

accatagatg gtctcaaagc taccaaaaac tttcttcact gtcttgggcg gtatggcaac     1140

actccatttt tgtttccttt atatggccaa ggagaactcc cccagtgttt ctgcaggatg     1200

tgtgctgtgt ttggtggaat ttattgtctt cgccattcag tacagtgcct tgtagtggac     1260

aaagaatcca gaaaatgtaa agcaattata gatcagtttg gtcagagaat aatctctgag     1320

catttcctcg tggaggacag ttactttcct gagaacatgt gctcacgtgt gcaatacagg     1380

cagatctcca gggcagtgct gattacagat agatctgtcc taaaaacaga ttcagatcaa     1440

cagatttcca ttttgacagt gccagcagag gaaccaggaa cttttgctgt tcgggtcatt     1500

gagttatgtt cttcaacgat gacatgcatg aaaggcacct atttggttca tttgacttgc     1560

acatcttcta aaacagcaag agaagattta gaatcagttg tgcagaaatt gtttgttcca     1620

tatactgaaa tggagataga aaatgaacaa gtagaaaagc caagaattct gtgggctctt     1680

tacttcaata tgagagattc gtcagacatc agcaggagct gttataatga tttaccatcc     1740

aacgtttatg tctgctctgg cccagattgt ggtttaggaa atgataatgc agtcaaacag     1800

gctgaaacac ttttccagga aatctgcccc aatgaagatt tctgtccccc tccaccaaat     1860

cctgaagaca ttatccttga tggagacagt ttacagccag aggcttcaga atccagtgcc     1920

ataccagagg ctaactcgga gactttcaag gaaagcacaa accttggaaa cctagaggag     1980

tcctctgaat aa                                                         1992


<210>  10
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  11
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  11
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgc                   588


<210>  12
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  12
tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc       60

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga      120

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga      180

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat      240

ggcttctgag gcggaaagaa ccagctgggg                                       270


<210>  13
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gatt                                             144


<210>  14
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  14
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcaga      120

g                                                                      121


<210>  15
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  16
<211>  4213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  16
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggtaccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      240

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      300

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      360

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      420

tcgctattac catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc      480

cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg      540

cggggggggg gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg      600

cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta      660

tggcgaggcg gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg      720

ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc      780

tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct      840

gtaattagcg cttggtttaa tgacggcttg tttcttttct gtggctgcgt gaaagccttg      900

aggggctccg ggagggccct ttgtgcgggg ggagcggctc ggggctgtcc gcggggggac      960

ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc     1020

tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac     1080

gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tggatcctag cttgatatcg     1140

aattcctgca gcccggcggc accatggcgg atactctccc ttcggagttt gatgtgatcg     1200

taatagggac gggtttgcct gaatccatca ttgcagctgc atgttcaaga agtggccgga     1260

gagttctgca tgttgattca agaagctact atggaggaaa ctgggccagt tttagctttt     1320

caggactatt gtcctggcta aaggaatacc aggaaaacag tgacattgta agtgacagtc     1380

cagtgtggca agaccagatc cttgaaaatg aagaagccat tgctcttagc aggaaggaca     1440

aaactattca acatgtggaa gtattttgtt atgccagtca ggatttgcat gaagatgtcg     1500

aagaagctgg tgcactgcag aaaaatcatg ctcttgtgac atctgcaaac tccacagaag     1560

ctgcagattc tgccttcctg cctacggagg atgagtcatt aagcactatg agctgtgaaa     1620

tgctcacaga acaaactcca agcagcgatc cagagaatgc gctagaagta aatggtgctg     1680

aagtgacagg ggaaaaagaa aaccattgtg atgataaaac ttgtgtgcca tcaacttcag     1740

cagaagacat gagtgaaaat gtgcctatag cagaagatac cacagagcaa ccaaagaaaa     1800

acagaattac ttactcacaa attattaaag aaggcaggag atttaatatt gatttagtat     1860

caaagctgct gtattctcga ggattactaa ttgatcttct aatcaaatct aatgttagtc     1920

gatatgcaga gtttaaaaat attaccagga ttcttgcatt tcgagaagga cgagtggaac     1980

aggttccgtg ttccagagca gatgtcttta atagcaaaca acttactatg gtagaaaagc     2040

gaatgctaat gaaatttctt acattttgta tggaatatga gaaatatcct gatgaatata     2100

aaggatatga agagatcaca ttttatgaat atttaaagac tcaaaaatta acccccaacc     2160

tccaatatat tgtcatgcat tcaattgcaa tgacatcaga gacagccagc agcaccatag     2220

atggtctcaa agctaccaaa aactttcttc actgtcttgg gcggtatggc aacactccat     2280

ttttgtttcc tttatatggc caaggagaac tcccccagtg tttctgcagg atgtgtgctg     2340

tgtttggtgg aatttattgt cttcgccatt cagtacagtg ccttgtagtg gacaaagaat     2400

ccagaaaatg taaagcaatt atagatcagt ttggtcagag aataatctct gagcatttcc     2460

tcgtggagga cagttacttt cctgagaaca tgtgctcacg tgtgcaatac aggcagatct     2520

ccagggcagt gctgattaca gatagatctg tcctaaaaac agattcagat caacagattt     2580

ccattttgac agtgccagca gaggaaccag gaacttttgc tgttcgggtc attgagttat     2640

gttcttcaac gatgacatgc atgaaaggca cctatttggt tcatttgact tgcacatctt     2700

ctaaaacagc aagagaagat ttagaatcag ttgtgcagaa attgtttgtt ccatatactg     2760

aaatggagat agaaaatgaa caagtagaaa agccaagaat tctgtgggct ctttacttca     2820

atatgagaga ttcgtcagac atcagcagga gctgttataa tgatttacca tccaacgttt     2880

atgtctgctc tggcccagat tgtggtttag gaaatgataa tgcagtcaaa caggctgaaa     2940

cacttttcca ggaaatctgc cccaatgaag atttctgtcc ccctccacca aatcctgaag     3000

acattatcct tgatggagac agtttacagc cagaggcttc agaatccagt gccataccag     3060

aggctaactc ggagactttc aaggaaagca caaaccttgg aaacctagag gagtcctctg     3120

aataatctag tcgattcgaa ttcgatatca agcttatcga taatcaacct ctggattaca     3180

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3240

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3300

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3360

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     3420

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     3480

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     3540

tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga     3600

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     3660

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     3720

gtcggatctc cctttgggcc gcctccccgc atcgataccg tcgactcgct gatcagcctc     3780

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     3840

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     3900

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     3960

ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga     4020

aagaaccagc tggggctcga ctagagcatg gctacgtaga taagtagcat ggcgggttaa     4080

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4140

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggcggcctc agtgagcgag     4200

cgagcgcgca gag                                                        4213


<210>  17
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  17
atggcggata ctctcccttc ggagtttgat gtgatcgtaa tagggacggg tttgcctgaa       60

tccatcattg cagctgcatg ttcaagaagt ggccggagag ttctgcatgt tgattcaaga      120

agctactatg gaggaaactg ggccagtttt agcttttcag gactattgtc ctggctaaag      180

gaataccagg aaaacagtga cattgtaagt gacagtccag tgtggcaaga ccagatcctt      240

gaaaatgaag aagccattgc tcttagcagg aaggacaaaa ctattcaaca tgtggaagta      300

ttttgttatg ccagtcagga tttgcatgaa gatgtcgaag aagctggtgc actgcagaaa      360

aatcatgctc ttgtgacatc tgcaaactcc acagaagctg cagattctgc cttcctgcct      420

acggaggatg agtcattaag cactatgagc tgtgaaatgc tcacagaaca aactccaagc      480

agcgatccag agaatgcgct agaagtaaat ggtgctgaag tgacagggga aaaagaaaac      540

cattgtgatg ataaaacttg tgtgccatca acttcagcag aagacatgag tgaaaatgtg      600

cctatagcag aagataccac agagcaacca aagaaaaaca gaattactta ctcacaaatt      660

attaaagaag gcaggagatt taatattgat ttagtatcaa agctgctgta ttctcgagga      720

ttactaattg atcttctaat caaatctaat gttagtcgat atgcagagtt taaaaatatt      780

accaggattc ttgcatttcg agaaggacga gtggaacagg ttccgtgttc cagagcagat      840

gtctttaata gcaaacaact tactatggta gaaaagcgaa tgctaatgaa atttcttaca      900

ttttgtatgg aatatgagaa atatcctgat gaatataaag gatatgaaga gatcacattt      960

tatgaatatt taaagactca aaaattaacc cccaacctcc aatatattgt catgcattca     1020

attgcaatga catcagagac agccagcagc accatagatg gtctcaaagc taccaaaaac     1080

tttcttcact gtcttgggcg gtatggcaac actccatttt tgtttccttt atatggccaa     1140

ggagaactcc cccagtgttt ctgcaggatg tgtgctgtgt ttggtggaat ttattgtctt     1200

cgccattcag tacagtgcct tgtagtggac aaagaatcca gaaaatgtaa agcaattata     1260

gatcagtttg gtcagagaat aatctctgag catttcctcg tggaggacag ttactttcct     1320

gagaacatgt gctcacgtgt gcaatacagg cagatctcca gggcagtgct gattacagat     1380

agatctgtcc taaaaacaga ttcagatcaa cagatttcca ttttgacagt gccagcagag     1440

gaaccaggaa cttttgctgt tcgggtcatt gagttatgtt cttcaacgat gacatgcatg     1500

aaaggcacct atttggttca tttgacttgc acatcttcta aaacagcaag agaagattta     1560

gaatcagttg tgcagaaatt gtttgttcca tatactgaaa tggagataga aaatgaacaa     1620

gtagaaaagc caagaattct gtgggctctt tacttcaata tgagagattc gtcagacatc     1680

agcaggagct gttataatga tttaccatcc aacgtttatg tctgctctgg cccagattgt     1740

ggtttaggaa atgataatgc agtcaaacag gctgaaacac ttttccagga aatctgcccc     1800

aatgaagatt tctgtccccc tccaccaaat cctgaagaca ttatccttga tggagacagt     1860

ttacagccag aggcttcaga atccagtgcc ataccagagg ctaactcgga gactttcaag     1920

gaaagcacaa accttggaaa cctagaggag tcctctgaat aa                        1962


<210>  18
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  18
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga      600

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat      660

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg      720

ctccgggagg gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg      780

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag      840

agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct      900

ggttattgtg ctgtctcatc attttggcaa agaattggat cc                         942


<210>  19
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  19
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  20
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  20
cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc       60

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      120

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      180

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg      240

gcttctgagg cggaaagaac cagctgggg                                        269


<210>  21
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  22
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  22
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcaga      120

g                                                                      121


<210>  23
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcggata ctctcccttc ggagtttgat gtgatcgtaa tagggacggg tttgcctgaa       60

tccatcattg cagctgcatg ttcaagaagt ggccggagag ttctgcatgt tgattcaaga      120

agctactatg gaggaaactg ggccagtttt agcttttcag gactattgtc ctggctaaag      180

gaataccagg aaaacagtga cattgtaagt gacagtccag tgtggcaaga ccagatcctt      240

gaaaatgaag aagccattgc tcttagcagg aaggacaaaa ctattcaaca tgtggaagta      300

ttttgttatg ccagtcagga tttgcatgaa gatgtcgaag aagctggtgc actgcagaaa      360

aatcatgctc ttgtgacatc tgcaaactcc acagaagctg cagattctgc cttcctgcct      420

acggaggatg agtcattaag cactatgagc tgtgaaatgc tcacagaaca aactccaagc      480

agcgatccag agaatgcgct agaagtaaat ggtgctgaag tgacagggga aaaagaaaac      540

cattgtgatg ataaaacttg tgtgccatca acttcagcag aagacatgag tgaaaatgtg      600

cctatagcag aagataccac agagcaacca aagaaaaaca gaattactta ctcacaaatt      660

attaaagaag gcaggagatt taatattgat ttagtatcaa agctgctgta ttctcgagga      720

ttactaattg atcttctaat caaatctaat gttagtcgat atgcagagtt taaaaatatt      780

accaggattc ttgcatttcg agaaggacga gtggaacagg ttccgtgttc cagagcagat      840

gtctttaata gcaaacaact tactatggta gaaaagcgaa tgctaatgaa atttcttaca      900

ttttgtatgg aatatgagaa atatcctgat gaatataaag gatatgaaga gatcacattt      960

tatgaatatt taaagactca aaaattaacc cccaacctcc aatatattgt catgcattca     1020

attgcaatga catcagagac agccagcagc accatagatg gtctcaaagc taccaaaaac     1080

tttcttcact gtcttgggcg gtatggcaac actccatttt tgtttccttt atatggccaa     1140

ggagaactcc cccagtgttt ctgcaggatg tgtgctgtgt ttggtggaat ttattgtctt     1200

cgccattcag tacagtgcct tgtagtggac aaagaatcca gaaaatgtaa agcaattata     1260

gatcagtttg gtcagagaat aatctctgag catttcctcg tggaggacag ttactttcct     1320

gagaacatgt gctcacgtgt gcaatacagg cagatctcca gggcagtgct gattacagat     1380

agatctgtcc taaaaacaga ttcagatcaa cagatttcca ttttgacagt gccagcagag     1440

gaaccaggaa cttttgctgt tcgggtcatt gagttatgtt cttcaacgat gacatgcatg     1500

aaaggcacct atttggttca tttgacttgc acatcttcta aaacagcaag agaagattta     1560

gaatcagttg tgcagaaatt gtttgttcca tatactgaaa tggagataga aaatgaacaa     1620

gtagaaaagc caagaattct gtgggctctt tacttcaata tgagagattc gtcagacatc     1680

agcaggagct gttataatga tttaccatcc aacgtttatg tctgctctgg cccagattgt     1740

ggtttaggaa atgataatgc agtcaaacag gctgaaacac ttttccagga aatctgcccc     1800

aatgaagatt tctgtccccc tccaccaaat cctgaagaca ttatccttga tggagacagt     1860

ttacagccag aggcttcaga atccagtgcc ataccagagg ctaactcgga gactttcaag     1920

gaaagcacaa accttggaaa cctagaggag tcctctgaat aa                        1962


<210>  24
<211>  5357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  24
ctaaattgta agcgttaatt tttgttaaaa ttaaattttt gttaaatcag ctcatttttt       60

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg      120

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc      180

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca      240

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga      300

tttagagctt gacggggaaa gccggcgaag ctggcgagaa aggaagggaa gaaagcgaaa      360

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtcgt aaccaccaca      420

cccgccgcgc ttaatgcgcc gctacagggc gcgtcccatt cgccattcag gctgcgcaac      480

tgttgggaag ggcgatcggt gcgggcctct tcgctattac gccagctggc gaaaggggga      540

tgtgctgcaa ggcgattaag ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa      600

acgacggcca gtgagcgcgc gtaatacgac tcactatagg gcgaattggg taccgggccc      660

cccctcgagg tcgacggtat cgataagcta ggatcctagc tgatatcgaa ttcctgcagc      720

ccggcggcac catggcggat actctccctt cggagtttga tgtgatcgta atagggacgg      780

gtttgcctga atccatcatt gcagctgcat gttcaagaag tggccggaga gttctgcatg      840

ttgattcaaa gaagctacta tggaggaaac tgggccagtt ttagcttttc aggactattg      900

tcctggctaa aggaatacca ggaaaacagt gacattgtaa gtgacagtcc agtgtggcaa      960

gaccagatcc ttgaaaatga agaagccatt gctcttagca ggaaggacaa aactattcaa     1020

catgtggaag tattttgtta tgccagtcag gatttgcatg aagatgtcga agaagctggt     1080

cactgcagaa aaatcatgct cttgtgacat ctgcaaactc cacagaagct gcagattctg     1140

cctcctgcct acggaggatg agtcattaag cactatgagc tgtgaaatgc tcacagaaca     1200

aactccaagc agcgatccag agaatgcgcg ctagaagtaa atggtgctga agtgacaggg     1260

gaaaaagaaa accattgtga tgataaaact tgtgtgccat caacttacgc agaagacatg     1320

agtgaaaatg tcgctatagc agaagatacc acagagcaac caaagaaaaa cagaattact     1380

tactcacaaa ttattaaaga aggcaggaga tttaatattg atttagtatc aaagctgctg     1440

tattctcgag gattactaat tgatcttcta atcaaatcta atgttagtcg atatgcagag     1500

tttaaaaata ttaccaggat tcttgcattt cgagaggacg agtggaacag gttccgtgtt     1560

ccagagccag atgtctttaa tagcaaacaa cttactatgg tagaaagcga atgctaatga     1620

aatttcttac attttgtatg gaatatgaga aatatctgat gaatataaag gatatgaaga     1680

gatcacattt tatgaatatt taaagactca aaaattaacc cccaacctcc aatatattgt     1740

catgcattca attgcaatga catcagagac agccagcagc accatagatg gtctccaaag     1800

ctaccaaaaa ctttcttcac tgtcttgggc ggtatggcaa cactccattt ttgtttcctt     1860

tatatggcca aggagaactc ccccagtgtt tctgcaggat gtgtgctgtg tttggtggaa     1920

tttattgtct tcgccattca gtacagtgcc ttgtagtgga caaagaatcc agaaaatgta     1980

aagcaattat agatcagttt ggtcagagaa taatctctga gcatttcctc gtggaggaca     2040

gttactttcc tgagaacatg tgctcacgtg tgcaatacag gcagatctcc agggcagtgc     2100

tgattacaga tagatctgtc ctaaaaacag attcagatca acagatttcc attttgacag     2160

tgccagcaga ggaaccagaa cttttgctgt tcgggtcatt gagttatgtt cttcaacgat     2220

gacatgcatg aaaggcacct atttggttca tttgacttgc acatcttcta aaacagcaag     2280

agaagattta gaatcagttg tgcagaaatt gtttgttcca tatactgaaa tggagataga     2340

aaatgaacaa gtagaaaagc caagaattct gtgggctctt tacttcaata tgagagttcg     2400

tcagacatca gcaggagctc ttataatgat ttaccatcca acgtttatgt ctgctctggc     2460

ccagattgtg gtttaggaaa tgataatgca gtcaaacagg ctgaaacact tttccaggaa     2520

atctgcccca atgaagattt ctgtccccct ccaccaaatc cctgaagaca ttatccttga     2580

tggagacagt ttacagccag aggctcagaa tccagtgcca taccagaggc taactcggag     2640

actttcaagg aaagcacaaa ccttggaaac ctagaggagt cctctgaata attagagcgg     2700

ccaacgcgtt ggccgccacc gcggtggagc tccagctttt gttcccttta gtgagggtta     2760

attgcgcgct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc     2820

acaattccac acaacatacg accggaagca taaagtgtaa gcctggggtg cctaatgagt     2880

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc     2940

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg     3000

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     3060

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     3120

gaacatgtga gcaaaagcca gcaaaaggcc aggaaccgta aaaaggccgc gtgctggcgt     3180

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     3240

ggcgaaaccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     3300

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     3360

cgtggcgctt tctcatagct cacgcgtagg tatctcagtt cggtgtaggt cgttcgctcc     3420

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     3480

atctcttgag tccaacccgg taagacagac ttatcgccac tggcagccac tggtaacagg     3540

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     3600

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     3660

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttg     3720

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     3780

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     3840

tatcaaaaag gatcttcacc tagatccttt tcgaccgaat aaatacctgt gacggaagat     3900

cacttgcaaa taaataaatc cggttccctg ttgataccgg gaagccctgg gccaactttt     3960

ggcgaaaatg agacgttgat cggcacgtaa gaggttccaa ctttcaccat aatgaaataa     4020

gatcactacc gggcgtattt tttgagttgt cgagattttc aggagctaag gaagctaaaa     4080

tggagaaaaa aatcactgga tataccaccg ttgatatatc ccaatggcat cgtaaagaac     4140

attttgaggc atttcagtca gttgctcaat gtacctataa ccagaccgtt cagctggata     4200

ttacggcctt tttaaagacc gtaaagaaaa ataagcacaa gttttatccg gcctttattc     4260

acattcttgc ccgcctgatg aatgctcatc cggaattagt atggcaatga aagacggtga     4320

gctggtgata tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac     4380

gttttcatcg ctctggagtg aataccaacg agatttccgg cagtttctac acatatattc     4440

gcaagatgtg gcgtgttagg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat     4500

atgtttttcg tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc     4560

aatatggaaa cttcttcgcc ccgttttcac catgggcaaa tattatacgc aaggcgacaa     4620

ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtttg tgatggcttc     4680

catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca gggcggggcg     4740

taattttttt aaggcagtta ttggtgccct taaacgctgg ttgctacgcc tgaataatga     4800

taataagcgg atgaatggca gaaattcgaa agcaaattcg acccggtcgt cggttcaggg     4860

cagggtcgtt aaatagccgc ttatgtctat tgctggttta ccggtttatt gactaccgga     4920

agcagtgtga ccgtgtgctt cttctcaaat gcctgaggcc agtttgctca ggctctcccc     4980

gtggaggtaa taattgacga tatgatcctt tttttctgat caaaagtgct catcattgga     5040

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttgatgt     5100

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccacg tttctgggtg     5160

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     5220

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcaagggt tattgtctca     5280

tgagcggata catatttgaa tgtatttaga aaaataaaca ataggggttc cgcgcacatt     5340

tccccgaaaa gtgccac                                                    5357


<210>  25
<211>  4213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant synthesis

<400>  25
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggtaccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      240

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      300

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      360

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      420

tcgctattac catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc      480

cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg      540

cggggggggg gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg      600

cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta      660

tggcgaggcg gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg      720

ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc      780

tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct      840

gtaattagcg cttggtttaa tgacggcttg tttcttttct gtggctgcgt gaaagccttg      900

aggggctccg ggagggccct ttgtgcgggg ggagcggctc ggggctgtcc gcggggggac      960

ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc     1020

tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac     1080

gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tggatcctag cttgatatcg     1140

aattcctgca gcccggcggc accatggcgg atactctccc ttcggagttt gatgtgatcg     1200

taatagggac gggtttgcct gaatccatca ttgcagctgc atgttcaaga agtggccgga     1260

gagttctgca tgttgattca agaagctact atggaggaaa ctgggccagt tttagctttt     1320

caggactatt gtcctggcta aaggaatacc aggaaaacag tgacattgta agtgacagtc     1380

cagtgtggca agaccagatc cttgaaaatg aagaagccat tgctcttagc aggaaggaca     1440

aaactattca acatgtggaa gtattttgtt atgccagtca ggatttgcat gaagatgtcg     1500

aagaagctgg tgcactgcag aaaaatcatg ctcttgtgac atctgcaaac tccacagaag     1560

ctgcagattc tgccttcctg cctacggagg atgagtcatt aagcactatg agctgtgaaa     1620

tgctcacaga acaaactcca agcagcgatc cagagaatgc gctagaagta aatggtgctg     1680

aagtgacagg ggaaaaagaa aaccattgtg atgataaaac ttgtgtgcca tcaacttcag     1740

cagaagacat gagtgaaaat gtgcctatag cagaagatac cacagagcaa ccaaagaaaa     1800

acagaattac ttactcacaa attattaaag aaggcaggag atttaatatt gatttagtat     1860

caaagctgct gtattctcga ggattactaa ttgatcttct aatcaaatct aatgttagtc     1920

gatatgcaga gtttaaaaat attaccagga ttcttgcatt tcgagaagga cgagtggaac     1980

aggttccgtg ttccagagca gatgtcttta atagcaaaca acttactatg gtagaaaagc     2040

gaatgctaat gaaatttctt acattttgta tggaatatga gaaatatcct gatgaatata     2100

aaggatatga agagatcaca ttttatgaat atttaaagac tcaaaaatta acccccaacc     2160

tccaatatat tgtcatgcat tcaattgcaa tgacatcaga gacagccagc agcaccatag     2220

atggtctcaa agctaccaaa aactttcttc actgtcttgg gcggtatggc aacactccat     2280

ttttgtttcc tttatatggc caaggagaac tcccccagtg tttctgcagg atgtgtgctg     2340

tgtttggtgg aatttattgt cttcgccatt cagtacagtg ccttgtagtg gacaaagaat     2400

ccagaaaatg taaagcaatt atagatcagt ttggtcagag aataatctct gagcatttcc     2460

tcgtggagga cagttacttt cctgagaaca tgtgctcacg tgtgcaatac aggcagatct     2520

ccagggcagt gctgattaca gatagatctg tcctaaaaac agattcagat caacagattt     2580

ccattttgac agtgccagca gaggaaccag gaacttttgc tgttcgggtc attgagttat     2640

gttcttcaac gatgacatgc atgaaaggca cctatttggt tcatttgact tgcacatctt     2700

ctaaaacagc aagagaagat ttagaatcag ttgtgcagaa attgtttgtt ccatatactg     2760

aaatggagat agaaaatgaa caagtagaaa agccaagaat tctgtgggct ctttacttca     2820

atatgagaga ttcgtcagac atcagcagga gctgttataa tgatttacca tccaacgttt     2880

atgtctgctc tggcccagat tgtggtttag gaaatgataa tgcagtcaaa caggctgaaa     2940

cacttttcca ggaaatctgc cccaatgaag atttctgtcc ccctccacca aatcctgaag     3000

acattatcct tgatggagac agtttacagc cagaggcttc agaatccagt gccataccag     3060

aggctaactc ggagactttc aaggaaagca caaaccttgg aaacctagag gagtcctctg     3120

aataatctag tcgattcgaa ttcgatatca agcttatcga taatcaacct ctggattaca     3180

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3240

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3300

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3360

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     3420

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     3480

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     3540

tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga     3600

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     3660

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     3720

gtcggatctc cctttgggcc gcctccccgc atcgataccg tcgactcgct gatcagcctc     3780

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     3840

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     3900

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     3960

ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga     4020

aagaaccagc tggggctcga ctagagcatg gctacgtaga taagtagcat ggcgggttaa     4080

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4140

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggcggcctc agtgagcgag     4200

cgagcgcgca gag                                                        4213


