                         SEQUENCE LISTING

<110>  Trustees of the University of Pennsylvania
       Lambris, John D.
 
<120>  Compstatin Analogs with Increased Solubility and Improved 
       Pharmacokinetic Properties

<130>  34092-158

<150>  US 62/654,055
<151>  2018-04-06

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  1

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is missing or is Gly.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile, Val, Leu, Ac-Ile, Ac-Val, or Ac-Leu.

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Trp or an analog of Trp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Trp or an analog of Trp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is His, Ala, Phe or Trp

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is L-Thr, D-Thr, Ile, Val, or Gly.

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION (optional)

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is missing or is Asn or Ala.

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION (optional)

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is missing or is Asn.

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION (optional)

<400>  2

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is missing or is Gly.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile, Val, Leu, Ac-Ile, Ac-Val, or Ac-Leu.

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Trp or an analog of Trp.

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Trp or an analog of Trp.

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-METHYLATION

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is His, Ala, Phe, or Trp.

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is Thr, Ile, Leu, Nle, N-methyl Thr, or N-methyl Ile.

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION (optional)

<400>  3

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  4

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is missing or is Tyr, D-Tyr, or Sar.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile, Gly, or Ac-Trp.

<220>
<221>  DISULFID
<222>  (3)..(13)
<223>  optional disulfide bond or thioether bond

<220>
<221>  THIOETH
<222>  (3)..(13)
<223>  optional disulfide bond or thioether bond

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Trp or an analog of Trp.

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Asp or Asn.

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Trp or an analog of Trp.

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Methylation (optional)

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is His, Ala, Phe, or Trp.

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Arg or Orn.

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is Thr, Ile, Leu, Nle, N-methyl Thr, or N-methyl Ile.

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION (optional)

<400>  5

Xaa Xaa Cys Val Xaa Gln Xaa Xaa Gly Xaa His Xaa Cys Xaa 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  6

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is D-Tyr

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  7

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10                  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is D-Tyr

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  8

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Lys 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is D-Tyr

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  9

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Lys Lys 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is D-Tyr

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  10

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Lys Lys 
1               5                   10                  15      


Lys 
    


