                         SEQUENCE LISTING

<110>  DRAGONFLY THERAPEUTICS, INC.
 
<120>  ANTIBODY VARIABLE DOMAINS TARGETING DLL3, AND USE THEREOF

<130>  DFY-052WO

<150>  62/651,945
<151>  2018-04-03

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Asp Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Asn Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Cys Gly Thr Gly Pro Trp Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  2

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Asn Ile Gln Pro Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Phe Leu Ser Ser Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  3

Gln Leu Gln Leu Val Gln Ser Gly Pro Glu Leu Met Arg Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Gly Asn Tyr Gly Phe Asp Cys Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Trp Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  6

Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Pro Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ile Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Gly Asn Tyr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Val Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Asn Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  9

Gly Tyr Trp Ile Asp 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  10

Glu Ile Leu Pro Gly Ser Asp Asn Ile Asn Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  11

Cys Gly Thr Gly Pro Trp Phe Thr Tyr 
1               5                   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  12

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  13

Trp Ala Ser Thr Arg Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

His Gln Phe Leu Ser Ser Thr Trp Thr 
1               5                   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  15

Thr Tyr Gly Met Asn 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Phe Gly Asn Tyr Gly Phe Asp Cys 
1               5               


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  19

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  20

Gln Asn Asp His Ile Tyr Pro Tyr Thr 
1               5                   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  21

Asp Asp Tyr Ile His 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  22

Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  23

Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr 
1               5                   10      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  25

Leu Val Ser Lys Leu Glu Ser 
1               5           


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Leu Gln Thr Thr His Leu Tyr Thr 
1               5               


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  27

Thr Tyr Gly Val Asn 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  28

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  29

Phe Gly Asn Tyr Gly Phe Asp Tyr 
1               5               


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  30

Lys Ser Ser Gln Ser Leu Val Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  31

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  32

Gln Asn Asp His Asn Tyr Pro Tyr Thr 
1               5                   


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  34

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Glu Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Thr Tyr Trp Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  Ser, Thr or Glu

<220>
<221>  VARIANT
<222>  (102)..(102)
<223>  Tyr or Trp

<220>
<221>  VARIANT
<222>  (107)..(107)
<223>  Phe or Leu

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Xaa Tyr Xaa Ser Tyr Asp Leu Xaa Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  40

Asp Asp Tyr Ile His 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  41

Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  42

Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr 
1               5                   10      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  43

Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  44

Leu Val Ser Lys Leu Glu Ser 
1               5           


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  45

Leu Gln Thr Thr His Leu Tyr Thr 
1               5               


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  46

Ser Glu Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  47

Ser Ser Tyr Trp Ser Tyr Asp Leu Leu Val Tyr 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  48

Ser Ser Tyr Trp Ser Tyr Asp Leu Phe Val Tyr 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  49

Ser Thr Tyr Trp Ser Tyr Asp Leu Phe Val Tyr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, Thr or Glu

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Tyr or Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Phe or Leu

<400>  50

Ser Xaa Tyr Xaa Ser Tyr Asp Leu Xaa Val Tyr 
1               5                   10      


<210>  51
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr 
                165                 170                 175     


Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
            180                 185                 190         


Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Thr His Leu Tyr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  52
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  52

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
145                 150                 155                 160 


Lys Asp Asp Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala 
            180                 185                 190         


Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Thr Ser Ser Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  53
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  53
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggctt caacatcaag gacgactaca tccactgggt gaggcaggcc      120

cccggccagt gcctggagtg gatgggctgg atcgacagcg agaacggcga caccgagtac      180

gccagcaagt tccagggcag ggtgaccatc accgccgaca ccagcgccaa caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caccagcagc      300

tactacagct acgacctgtt cgtgtactgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc      420

gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      480

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      540

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      600

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      660

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      720

accttcggct gcggcaccaa gctggagatc aag                                   753


<210>  54
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  54
gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      120

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      180

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      240

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      300

accttcggct gcggcaccaa gctggagatc aagggcggcg gcggcagcgg cggcggcggc      360

agcggcggcg gcggcagcgg cggcggcggc agccaggtgc agctggtgca gagcggcgcc      420

gaggtgaaga agcccggcgc cagcgtgaag gtgagctgca aggccagcgg cttcaacatc      480

aaggacgact acatccactg ggtgaggcag gcccccggcc agtgcctgga gtggatgggc      540

tggatcgaca gcgagaacgg cgacaccgag tacgccagca agttccaggg cagggtgacc      600

atcaccgccg acaccagcgc caacaccgcc tacatggagc tgagcagcct gaggagcgag      660

gacaccgccg tgtactactg cgccaccagc agctactaca gctacgacct gttcgtgtac      720

tggggccagg gcaccctggt gaccgtgagc agc                                   753


<210>  55
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Glu Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr 
                165                 170                 175     


Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
            180                 185                 190         


Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Thr His Leu Tyr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  56
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  56

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
145                 150                 155                 160 


Lys Asp Asp Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala 
            180                 185                 190         


Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Thr Ser Glu Tyr Tyr Ser Tyr Asp Leu Phe Val Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  57
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  57
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggctt caacatcaag gacgactaca tccactgggt gaggcaggcc      120

cccggccagt gcctggagtg gatgggctgg atcgacagcg agaacggcga caccgagtac      180

gccagcaagt tccagggcag ggtgaccatc accgccgaca ccagcgccaa caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caccagcgag      300

tactacagct acgacctgtt cgtgtactgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc      420

gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      480

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      540

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      600

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      660

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      720

accttcggct gcggcaccaa gctggagatc aag                                   753


<210>  58
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  58
gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      120

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      180

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      240

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      300

accttcggct gcggcaccaa gctggagatc aagggcggcg gcggcagcgg cggcggcggc      360

agcggcggcg gcggcagcgg cggcggcggc agccaggtgc agctggtgca gagcggcgcc      420

gaggtgaaga agcccggcgc cagcgtgaag gtgagctgca aggccagcgg cttcaacatc      480

aaggacgact acatccactg ggtgaggcag gcccccggcc agtgcctgga gtggatgggc      540

tggatcgaca gcgagaacgg cgacaccgag tacgccagca agttccaggg cagggtgacc      600

atcaccgccg acaccagcgc caacaccgcc tacatggagc tgagcagcct gaggagcgag      660

gacaccgccg tgtactactg cgccaccagc gagtactaca gctacgacct gttcgtgtac      720

tggggccagg gcaccctggt gaccgtgagc agc                                   753


<210>  59
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr 
                165                 170                 175     


Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
            180                 185                 190         


Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Thr His Leu Tyr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  60
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  60

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
145                 150                 155                 160 


Lys Asp Asp Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala 
            180                 185                 190         


Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Leu Val Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  61
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  61
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggctt caacatcaag gacgactaca tccactgggt gaggcaggcc      120

cccggccagt gcctggagtg gatgggctgg atcgacagcg agaacggcga caccgagtac      180

gccagcaagt tccagggcag ggtgaccatc accgccgaca ccagcgccaa caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caccagcagc      300

tactggagct acgacctgct ggtgtactgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc      420

gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      480

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      540

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      600

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      660

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      720

accttcggct gcggcaccaa gctggagatc aag                                   753


<210>  62
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  62
gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      120

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      180

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      240

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      300

accttcggct gcggcaccaa gctggagatc aagggcggcg gcggcagcgg cggcggcggc      360

agcggcggcg gcggcagcgg cggcggcggc agccaggtgc agctggtgca gagcggcgcc      420

gaggtgaaga agcccggcgc cagcgtgaag gtgagctgca aggccagcgg cttcaacatc      480

aaggacgact acatccactg ggtgaggcag gcccccggcc agtgcctgga gtggatgggc      540

tggatcgaca gcgagaacgg cgacaccgag tacgccagca agttccaggg cagggtgacc      600

atcaccgccg acaccagcgc caacaccgcc tacatggagc tgagcagcct gaggagcgag      660

gacaccgccg tgtactactg cgccaccagc agctactgga gctacgacct gctggtgtac      720

tggggccagg gcaccctggt gaccgtgagc agc                                   753


<210>  63
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr 
                165                 170                 175     


Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
            180                 185                 190         


Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Thr His Leu Tyr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  64
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  64

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
145                 150                 155                 160 


Lys Asp Asp Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala 
            180                 185                 190         


Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Thr Ser Ser Tyr Trp Ser Tyr Asp Leu Phe Val Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  65
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  65
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggctt caacatcaag gacgactaca tccactgggt gaggcaggcc      120

cccggccagt gcctggagtg gatgggctgg atcgacagcg agaacggcga caccgagtac      180

gccagcaagt tccagggcag ggtgaccatc accgccgaca ccagcgccaa caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caccagcagc      300

tactggagct acgacctgtt cgtgtactgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc      420

gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      480

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      540

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      600

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      660

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      720

accttcggct gcggcaccaa gctggagatc aag                                   753


<210>  66
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  66
gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      120

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      180

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      240

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      300

accttcggct gcggcaccaa gctggagatc aagggcggcg gcggcagcgg cggcggcggc      360

agcggcggcg gcggcagcgg cggcggcggc agccaggtgc agctggtgca gagcggcgcc      420

gaggtgaaga agcccggcgc cagcgtgaag gtgagctgca aggccagcgg cttcaacatc      480

aaggacgact acatccactg ggtgaggcag gcccccggcc agtgcctgga gtggatgggc      540

tggatcgaca gcgagaacgg cgacaccgag tacgccagca agttccaggg cagggtgacc      600

atcaccgccg acaccagcgc caacaccgcc tacatggagc tgagcagcct gaggagcgag      660

gacaccgccg tgtactactg cgccaccagc agctactgga gctacgacct gttcgtgtac      720

tggggccagg gcaccctggt gaccgtgagc agc                                   753


<210>  67
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Thr Tyr Trp Ser Tyr Asp Leu Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr 
                165                 170                 175     


Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
            180                 185                 190         


Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Thr His Leu Tyr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


<210>  68
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  68

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
145                 150                 155                 160 


Lys Asp Asp Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asp Ser Glu Asn Gly Asp Thr Glu Tyr Ala 
            180                 185                 190         


Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Asn 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Thr Ser Thr Tyr Trp Ser Tyr Asp Leu Phe Val Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  69
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  69
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggctt caacatcaag gacgactaca tccactgggt gaggcaggcc      120

cccggccagt gcctggagtg gatgggctgg atcgacagcg agaacggcga caccgagtac      180

gccagcaagt tccagggcag ggtgaccatc accgccgaca ccagcgccaa caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caccagcacc      300

tactggagct acgacctgtt cgtgtactgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc      420

gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      480

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      540

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      600

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      660

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      720

accttcggct gcggcaccaa gctggagatc aag                                   753


<210>  70
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Nucleotide sequence encoding 
       synthetic polypeptide

<400>  70
gacgtgcaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg cacagcaacg gcaagaccta cctgaactgg      120

ctgcagcaga agcccggcca ggcccccaag ctgctgctgt acctggtgag caagctggag      180

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgactacac cctgaccatc      240

agcagcctgc agcccgagga cttcgccacc tactactgcc tgcagaccac ccacctgtac      300

accttcggct gcggcaccaa gctggagatc aagggcggcg gcggcagcgg cggcggcggc      360

agcggcggcg gcggcagcgg cggcggcggc agccaggtgc agctggtgca gagcggcgcc      420

gaggtgaaga agcccggcgc cagcgtgaag gtgagctgca aggccagcgg cttcaacatc      480

aaggacgact acatccactg ggtgaggcag gcccccggcc agtgcctgga gtggatgggc      540

tggatcgaca gcgagaacgg cgacaccgag tacgccagca agttccaggg cagggtgacc      600

atcaccgccg acaccagcgc caacaccgcc tacatggagc tgagcagcct gaggagcgag      660

gacaccgccg tgtactactg cgccaccagc acctactgga gctacgacct gttcgtgtac      720

tggggccagg gcaccctggt gaccgtgagc agc                                   753


