
                                SEQUENCE LISTING

<110> Crystal, Ronald G.
      Kaminsky, Stephen M.
      Salami, Christiana
      Cornell Research Foundation, Inc.

<120> GENE THERAPY FOR OXIDATIVE STRESS
  

<130> 1676.131WO1

<140> PCT/US2019/025529   
<141> 2019-04-03  

<150> US 62/652,098       
<151> 2018-04-03  

<160> 13

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 527
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys
 1               5                  10                  15
Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly
            20                  25                  30
Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly
        35                  40                  45
Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe
    50                  55                  60
Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly
65                  70                  75                  80
Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys
                85                  90                  95
Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg
            100                 105                 110
Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp
        115                 120                 125
Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp
    130                 135                 140
Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu
145                 150                 155                 160
Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu
                165                 170                 175
Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser
            180                 185                 190
Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly
        195                 200                 205
His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn
    210                 215                 220
Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln
225                 230                 235                 240
Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu
                245                 250                 255
Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly
            260                 265                 270
Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln
        275                 280                 285
Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro
    290                 295                 300
His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg
305                 310                 315                 320
Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro
                325                 330                 335
Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln
            340                 345                 350
Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro
        355                 360                 365
Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala
    370                 375                 380
Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly
385                 390                 395                 400
Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro
                405                 410                 415
Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe
            420                 425                 430
Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val
        435                 440                 445
Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala
    450                 455                 460
Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys
465                 470                 475                 480
Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu
                485                 490                 495
Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe
            500                 505                 510
Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu
        515                 520                 525

<210> 2
<211> 240
<212> PRT
<213> Homo sapiens

<400> 2
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
 1               5                  10                  15
Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
            20                  25                  30
Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
        35                  40                  45
Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln
    50                  55                  60
Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
65                  70                  75                  80
Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                85                  90                  95
Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110
Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125
Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140
Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160
Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg
                165                 170                 175
Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn
            180                 185                 190
Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys
        195                 200                 205
Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu
    210                 215                 220
His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala
225                 230                 235                 240

<210> 3
<211> 240
<212> PRT
<213> Homo sapiens

<400> 3
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
 1               5                  10                  15
Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
            20                  25                  30
Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
        35                  40                  45
Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln
    50                  55                  60
Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
65                  70                  75                  80
Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                85                  90                  95
Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110
Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125
Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140
Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160
Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg
                165                 170                 175
Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn
            180                 185                 190
Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys
        195                 200                 205
Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu
    210                 215                 220
His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala
225                 230                 235                 240

<210> 4
<211> 240
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
 1               5                  10                  15
Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
            20                  25                  30
Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
        35                  40                  45
Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln
    50                  55                  60
Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
65                  70                  75                  80
Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                85                  90                  95
Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110
Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125
Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140
Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160
Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg
                165                 170                 175
Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn
            180                 185                 190
Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys
        195                 200                 205
Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu
    210                 215                 220
His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala
225                 230                 235                 240

<210> 5

<400> 5
 000

<210> 6
<211> 527
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys
 1               5                  10                  15
Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly
            20                  25                  30
Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly
        35                  40                  45
Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe
    50                  55                  60
Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly
65                  70                  75                  80
Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys
                85                  90                  95
Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg
            100                 105                 110
Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp
        115                 120                 125
Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp
    130                 135                 140
Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu
145                 150                 155                 160
Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu
                165                 170                 175
Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser
            180                 185                 190
Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly
        195                 200                 205
His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn
    210                 215                 220
Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln
225                 230                 235                 240
Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu
                245                 250                 255
Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly
            260                 265                 270
Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln
        275                 280                 285
Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro
    290                 295                 300
His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg
305                 310                 315                 320
Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro
                325                 330                 335
Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln
            340                 345                 350
Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro
        355                 360                 365
Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala
    370                 375                 380
Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly
385                 390                 395                 400
Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro
                405                 410                 415
Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe
            420                 425                 430
Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val
        435                 440                 445
Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala
    450                 455                 460
Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys
465                 470                 475                 480
Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu
                485                 490                 495
Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe
            500                 505                 510
Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu
        515                 520                 525

<210> 7
<211> 527
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys
 1               5                  10                  15
Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly
            20                  25                  30
Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly
        35                  40                  45
Pro Leu Leu Val Gln Asn Val Val Phe Thr Asp Glu Met Ala His Phe
    50                  55                  60
Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly
65                  70                  75                  80
Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys
                85                  90                  95
Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg
            100                 105                 110
Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp
        115                 120                 125
Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp
    130                 135                 140
Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu
145                 150                 155                 160
Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu
                165                 170                 175
Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser
            180                 185                 190
Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly
        195                 200                 205
His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn
    210                 215                 220
Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Gly Gln
225                 230                 235                 240
Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu
                245                 250                 255
Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly
            260                 265                 270
Lys Asp Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln
        275                 280                 285
Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Arg Val Trp Pro
    290                 295                 300
His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg
305                 310                 315                 320
Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro
                325                 330                 335
Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln
            340                 345                 350
Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro
        355                 360                 365
Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala
    370                 375                 380
Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly
385                 390                 395                 400
Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro
                405                 410                 415
Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe
            420                 425                 430
Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val
        435                 440                 445
Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala
    450                 455                 460
Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys
465                 470                 475                 480
Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu
                485                 490                 495
Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe
            500                 505                 510
Val Arg Ser Gly Ser His Leu Val Ala Arg Glu Lys Ala Asn Leu
        515                 520                 525

<210> 8
<211> 241
<212> PRT
<213> Homo sapiens

<400> 8
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
 1               5                  10                  15
Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
            20                  25                  30
Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
        35                  40                  45
Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln
    50                  55                  60
Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
65                  70                  75                  80
Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                85                  90                  95
Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110
Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125
Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140
Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160
Ala Gly Leu Ala Ala Ser Ser Leu Ala Gly Pro His Ser Ile Val Gly
                165                 170                 175
Arg Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly
            180                 185                 190
Asn Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys
        195                 200                 205
Cys Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg
    210                 215                 220
Glu His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala
225                 230                 235                 240
Ala


<210> 9
<211> 1518
<212> DNA
<213> Homo sapiens

<400> 9
gctgacagcc gggatcccgc cagcgaccag atgcagcact ggaaggagca gcgggccgcg      60
cagaaagctg atgtcctgac cactggagct ggtaacccag taggagacaa acttaatgtt     120
attacagtag ggccccgtgg gccccttctt gttcaggatg tggttttcac tgatgaaatg     180
gctcattttg accgagagag aattcctgag agagttgtgc atgctaaagg agcaggggcc     240
tttggctact ttgaggtcac acatgacatt accaaatact ccaaggcaaa ggtatttgag     300
catattggaa agaagactcc catcgcagtt cggttctcca ctgttgctgg agaatcgggt     360
tcagctgaca cagttcggga ccctcgtggg tttgcagtga aattttacac agaagatggt     420
aactgggatc tcgttggaaa taacaccccc attttcttca tcagggatcc catattgttt     480
ccatctttta tccacagcca aaagagaaat cctcagacac atctgaagga tccggacatg     540
gtctgggact tctggagcct acgtcctgag tctctgcatc aggtttcttt cttgttcagt     600
gatcggggga ttccagatgg acatcgccac atgaatggat atggatcaca tactttcaag     660
ctggttaatg caaatgggga ggcagtttat tgcaaattcc attataagac tgaccagggc     720
atcaaaaacc tttctgttga agatgcggcg agactttccc aggaagatcc tgactatggc     780
atccgggatc tttttaacgc cattgccaca ggaaagtacc cctcctggac tttttacatc     840
caggtcatga catttaatca ggcagaaact tttccattta atccattcga tctcaccaag     900
gtttggcctc acaaggacta ccctctcatc ccagttggta aactggtctt aaaccggaat     960
ccagttaatt actttgctga ggttgaacag atagccttcg acccaagcaa catgccacct    1020
ggcattgagg ccagtcctga caaaatgctt cagggccgcc tttttgccta tcctgacact    1080
caccgccatc gcctgggacc caattatctt catatacctg tgaactgtcc ctaccgtgct    1140
ccaaattact accccaacag ctttggtgct ccggaacaac agccttctgc cctggagcac    1200
agcatccaat attctggaga agtgcggaga ttcaacactg ccaatgatga taacgttact    1260
caggtgcggg cattctatgt gaacgtgctg aatgaggaac agaggaaacg tctgtgtgag    1320
aacattgccg gccacctgaa ggatgcacaa attttcatcc agaagaaagc ggtcaagaac    1380
ttcactgagg tccaccctga ctacgggagc cacatccagg ctcttctgga caagtacaat    1440
gctgagaagc ctaagaatgc gattcacacc tttgtgcagt ccggatctca cttggcggca    1500
agggagaagg caaatctg                                                  1518

<210> 10
<211> 208
<212> PRT
<213> Homo sapiens

<400> 10
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
 1               5                  10                  15
Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
            20                  25                  30
Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
        35                  40                  45
Val Ala Thr Leu Asp Ala Ala Gln His Ala Ala Cys Gln Val Gln Pro
    50                  55                  60
Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly Val Val Leu
65                  70                  75                  80
Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe Phe Ala Leu
                85                  90                  95
Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala Ile His Val
            100                 105                 110
His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr Gly Pro His
        115                 120                 125
Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly Asp Phe Gly
    130                 135                 140
Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg Ala Gly Leu
145                 150                 155                 160
Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg Ala Val Val
                165                 170                 175
Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn Gln Ala Ser
            180                 185                 190
Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys Val Val Gly
        195                 200                 205

<210> 11
<211> 624
<212> DNA
<213> Homo sapiens

<400> 11
atgctggcgc tactgtgttc ctgcctgctc ctggcagccg gtgcctcgga cgcctggacg      60
ggcgaggact cggcggagcc caactctgac tcggcggagt ggatccgaga catgtacgcc     120
aaggtcacgg agatctggca ggaggtcgcc acgctggacg ccgcgcagca cgccgcctgc     180
caggtgcagc cgtcggccac gctggacgcc gcgcagcccc gggtgaccgg cgtcgtcctc     240
ttccggcagc ttgcgccccg cgccaagctc gacgccttct tcgccctgga gggcttcccg     300
accgagccga acagctccag ccgcgccatc cacgtgcacc agttcgggga cctgagccag     360
ggctgcgagt ccaccgggcc ccactacaac ccgctggccg tgccgcaccc gcagcacccg     420
ggcgacttcg gcaacttcgc ggtccgcgac ggcagcctct ggaggtaccg cgccggcctg     480
gccgcctcgc tcgcgggccc gcactccatc gtgggccggg ccgtggtcgt ccacgctggc     540
gaggacgacc tgggccgcgg cggcaaccag gccagcgtgg agaacgggaa cgcgggccgg     600
cggctggcct gctgcgtggt gggc                                            624

<210> 12
<211> 538
<212> PRT
<213> Homo sapiens

<400> 12
Ala Pro Arg Ala Ala Thr Met Pro Arg Val Arg Ser Cys Leu Leu His
 1               5                  10                  15
Ser Pro Arg Thr His Ala Leu Ala Asp Ser Arg Asp Pro Ala Ser Asp
            20                  25                  30
Gln Met Gln His Trp Lys Glu Gln Arg Ala Ala Gln Lys Ala Asp Val
        35                  40                  45
Leu Thr Thr Gly Ala Gly Asn Pro Val Gly Asp Lys Leu Asn Val Ile
    50                  55                  60
Thr Val Gly Pro Arg Gly Pro Leu Leu Val Gln Asp Val Val Phe Thr
65                  70                  75                  80
Asp Glu Met Ala His Phe Asp Arg Glu Arg Ile Pro Glu Arg Val Val
                85                  90                  95
His Ala Lys Gly Ala Gly Ala Phe Gly Tyr Phe Glu Val Thr His Asp
            100                 105                 110
Ile Thr Lys Tyr Ser Lys Ala Lys Val Phe Glu His Ile Gly Lys Lys
        115                 120                 125
Thr Pro Ile Ala Val Arg Phe Ser Thr Val Ala Gly Glu Ser Gly Ser
    130                 135                 140
Ala Asp Thr Val Arg Asp Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr
145                 150                 155                 160
Glu Asp Gly Asn Trp Asp Leu Val Gly Asn Asn Thr Pro Ile Phe Phe
                165                 170                 175
Ile Arg Asp Pro Ile Leu Phe Pro Ser Phe Ile His Ser Gln Lys Arg
            180                 185                 190
Asn Pro Gln Thr His Leu Lys Asp Pro Asp Met Val Trp Asp Phe Trp
        195                 200                 205
Ser Leu Arg Pro Glu Ser Leu His Gln Val Ser Phe Leu Phe Ser Asp
    210                 215                 220
Arg Gly Ile Pro Asp Gly His Arg His Met Asn Gly Tyr Gly Ser His
225                 230                 235                 240
Thr Phe Lys Leu Val Asn Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe
                245                 250                 255
His Tyr Lys Thr Asp Gln Gly Ile Lys Asn Leu Ser Val Glu Asp Ala
            260                 265                 270
Ala Arg Leu Ser Gln Glu Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe
        275                 280                 285
Asn Ala Ile Ala Thr Gly Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln
    290                 295                 300
Val Met Thr Phe Asn Gln Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp
305                 310                 315                 320
Leu Thr Lys Val Trp Pro His Lys Asp Tyr Pro Leu Ile Pro Val Gly
                325                 330                 335
Lys Leu Val Leu Asn Arg Asn Pro Val Asn Tyr Phe Ala Glu Val Glu
            340                 345                 350
Gln Ile Ala Phe Asp Pro Ser Asn Met Pro Pro Gly Ile Glu Ala Ser
        355                 360                 365
Pro Asp Lys Met Leu Gln Gly Arg Leu Phe Ala Tyr Pro Asp Thr His
    370                 375                 380
Arg His Arg Leu Gly Pro Asn Tyr Leu His Ile Pro Val Asn Cys Pro
385                 390                 395                 400
Tyr Arg Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln
                405                 410                 415
Gln Pro Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg
            420                 425                 430
Arg Phe Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe
        435                 440                 445
Tyr Val Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn
    450                 455                 460
Ile Ala Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala
465                 470                 475                 480
Val Lys Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln
                485                 490                 495
Ala Leu Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His
            500                 505                 510
Thr Phe Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn
        515                 520                 525
Leu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
    530                 535

<210> 13
<211> 1569
<212> DNA
<213> Homo sapiens

<400> 13
atgccacgcg tccgctcctg tcttctccac agtcccagaa cacacgcact cgctgacagc      60
cgggatcccg ccagcgacca gatgcagcac tggaaggagc agcgggccgc gcagaaagct     120
gatgtcctga ccactggagc tggtaaccca gtaggagaca aacttaatgt tattacagta     180
gggccccgtg ggccccttct tgttcaggat gtggttttca ctgatgaaat ggctcatttt     240
gaccgagaga gaattcctga gagagttgtg catgctaaag gagcaggggc ctttggctac     300
tttgaggtca cacatgacat taccaaatac tccaaggcaa aggtatttga gcatattgga     360
aagaagactc ccatcgcagt tcggttctcc actgttgctg gagaatcggg ttcagctgac     420
acagttcggg accctcgtgg gtttgcagtg aaattttaca cagaagatgg taactgggat     480
ctcgttggaa ataacacccc cattttcttc atcagggatc ccatattgtt tccatctttt     540
atccacagcc aaaagagaaa tcctcagaca catctgaagg atccggacat ggtctgggac     600
ttctggagcc tacgtcctga gtctctgcat caggtttctt tcttgttcag tgatcggggg     660
attccagatg gacatcgcca catgaatgga tatggatcac atactttcaa gctggttaat     720
gcaaatgggg aggcagttta ttgcaaattc cattataaga ctgaccaggg catcaaaaac     780
ctttctgttg aagatgcggc gagactttcc caggaagatc ctgactatgg catccgggat     840
ctttttaacg ccattgccac aggaaagtac ccctcctgga ctttttacat ccaggtcatg     900
acatttaatc aggcagaaac ttttccattt aatccattcg atctcaccaa ggtttggcct     960
cacaaggact accctctcat cccagttggt aaactggtct taaaccggaa tccagttaat    1020
tactttgctg aggttgaaca gatagccttc gacccaagca acatgccacc tggcattgag    1080
gccagtcctg acaaaatgct tcagggccgc ctttttgcct atcctgacac tcaccgccat    1140
cgcctgggac ccaattatct tcatatacct gtgaactgtc cctaccgtgc tccaaattac    1200
taccccaaca gctttggtgc tccggaacaa cagccttctg ccctggagca cagcatccaa    1260
tattctggag aagtgcggag attcaacact gccaatgatg ataacgttac tcaggtgcgg    1320
gcattctatg tgaacgtgct gaatgaggaa cagaggaaac gtctgtgtga gaacattgcc    1380
ggccacctga aggatgcaca aattttcatc cagaagaaag cggtcaagaa cttcactgag    1440
gtccaccctg actacgggag ccacatccag gctcttctgg acaagtacaa tgctgagaag    1500
cctaagaatg cgattcacac ctttgtgcag tccggatctc acttggcggc aagggagaag    1560
gcaaatctg                                                            1569












