                         SEQUENCE LISTING

<110>  Duan, Dongsheng
       Wasala, Lakmini
       Lai, Yi
       Yue, Yongping
 
<120>  HINGES 1 AND/OR 4 MODIFIED DYSTROPHINS FOR DYSTROPHINOPATHY 
       THERAPY

<130>  18UMC046

<150>  US 62/651,772
<151>  2018-04-03

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  3685
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Leu Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  2
<211>  3678
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Asp Asn Leu Phe Ser Asp Leu Gln Asp Gly Lys 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Lys Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Thr Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Ser Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Ser Gln His Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Lys Cys Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Thr Ser Ser Lys Val Thr Arg Glu Glu His Phe Gln Leu His His Gln 
            260                 265                 270         


Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu 
        275                 280                 285             


Gln Thr Ser Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Phe Thr 
    290                 295                 300                 


Gln Ala Ala Tyr Val Ala Thr Ser Asp Ser Thr Gln Ser Pro Tyr Pro 
305                 310                 315                 320 


Ser Gln His Leu Glu Ala Pro Arg Asp Lys Ser Leu Asp Ser Ser Leu 
                325                 330                 335     


Met Glu Thr Glu Val Asn Leu Asp Ser Tyr Gln Thr Ala Leu Glu Glu 
            340                 345                 350         


Val Leu Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Arg Ala Gln Gly 
        355                 360                 365             


Glu Ile Ser Asn Asp Val Glu Glu Val Lys Glu Gln Phe His Ala His 
    370                 375                 380                 


Glu Gly Phe Met Met Asp Leu Thr Ser His Gln Gly Leu Val Gly Asn 
385                 390                 395                 400 


Val Leu Gln Leu Gly Ser Gln Leu Val Gly Lys Gly Lys Leu Ser Glu 
                405                 410                 415     


Asp Glu Glu Ala Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg 
            420                 425                 430         


Trp Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Lys Leu His 
        435                 440                 445             


Lys Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asp Asp 
    450                 455                 460                 


Trp Leu Thr Lys Thr Glu Glu Arg Thr Lys Lys Met Glu Glu Glu Pro 
465                 470                 475                 480 


Phe Gly Pro Asp Leu Glu Asp Leu Lys Cys Gln Val Gln Gln His Lys 
                485                 490                 495     


Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu 
            500                 505                 510         


Thr His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr 
        515                 520                 525             


Ala Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn 
    530                 535                 540                 


Ile Cys Arg Trp Thr Glu Asp Arg Trp Ile Val Leu Gln Asp Ile Leu 
545                 550                 555                 560 


Leu Lys Trp Gln His Phe Thr Glu Glu Gln Cys Leu Phe Ser Thr Trp 
                565                 570                 575     


Leu Ser Glu Lys Glu Asp Ala Met Lys Asn Ile Gln Thr Ser Gly Phe 
            580                 585                 590         


Lys Asp Gln Asn Glu Met Met Ser Ser Leu His Lys Ile Ser Thr Leu 
        595                 600                 605             


Lys Ile Asp Leu Glu Lys Lys Lys Pro Thr Met Glu Lys Leu Ser Ser 
    610                 615                 620                 


Leu Asn Gln Asp Leu Leu Ser Ala Leu Lys Asn Lys Ser Val Thr Gln 
625                 630                 635                 640 


Lys Met Glu Ile Trp Met Glu Asn Phe Ala Gln Arg Trp Asp Asn Leu 
                645                 650                 655     


Thr Gln Lys Leu Glu Lys Ser Ser Ala Gln Ile Ser Gln Ala Val Thr 
            660                 665                 670         


Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr 
        675                 680                 685             


Met Val Thr Thr Arg Glu Gln Ile Met Val Lys His Ala Gln Glu Glu 
    690                 695                 700                 


Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
705                 710                 715                 720 


Glu Leu Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp 
                725                 730                 735     


Ile Thr Arg Ser Glu Ala Val Leu Gln Ser Ser Glu Phe Ala Val Tyr 
            740                 745                 750         


Arg Lys Glu Gly Asn Ile Ser Asp Leu Gln Glu Lys Val Asn Ala Ile 
        755                 760                 765             


Ala Arg Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg 
    770                 775                 780                 


Ser Ala Gln Ala Leu Val Glu Gln Met Ala Asn Glu Gly Val Asn Ala 
785                 790                 795                 800 


Glu Ser Ile Arg Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Thr Glu 
                805                 810                 815     


Phe Cys Gln Leu Leu Ser Glu Arg Val Asn Trp Leu Glu Tyr Gln Thr 
            820                 825                 830         


Asn Ile Ile Thr Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr 
        835                 840                 845             


Thr Thr Ala Glu Asn Leu Leu Lys Thr Gln Ser Thr Thr Leu Ser Glu 
    850                 855                 860                 


Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn 
865                 870                 875                 880 


Arg Leu Ser Ala Leu Gln Pro Gln Ile Glu Gln Leu Lys Ile Gln Ser 
                885                 890                 895     


Leu Gln Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp 
            900                 905                 910         


Phe Val Ala Phe Thr Asn His Phe Asn His Ile Phe Asp Gly Val Arg 
        915                 920                 925             


Ala Lys Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met 
    930                 935                 940                 


Arg Tyr Gln Glu Thr Met Ser Ser Ile Arg Thr Trp Ile Gln Gln Ser 
945                 950                 955                 960 


Glu Ser Lys Leu Ser Val Pro Tyr Leu Ser Val Thr Glu Tyr Glu Ile 
                965                 970                 975     


Met Glu Glu Arg Leu Gly Lys Leu Gln Ala Leu Gln Ser Ser Leu Lys 
            980                 985                 990         


Glu Gln Gln Asn Gly Phe Asn Tyr  Leu Ser Asp Thr Val  Lys Glu Met 
        995                 1000                 1005             


Ala Lys  Lys Ala Pro Ser Glu  Ile Cys Gln Lys Tyr  Leu Ser Glu 
    1010                 1015                 1020             


Phe Glu  Glu Ile Glu Gly His  Trp Lys Lys Leu Ser  Ser Gln Leu 
    1025                 1030                 1035             


Val Glu  Ser Cys Gln Lys Leu  Glu Glu His Met Asn  Lys Leu Arg 
    1040                 1045                 1050             


Lys Phe  Gln Asn His Ile Lys  Thr Leu Gln Lys Trp  Met Ala Glu 
    1055                 1060                 1065             


Val Asp  Val Phe Leu Lys Glu  Glu Trp Pro Ala Leu  Gly Asp Ala 
    1070                 1075                 1080             


Glu Ile  Leu Lys Lys Gln Leu  Lys Gln Cys Arg Leu  Leu Val Gly 
    1085                 1090                 1095             


Asp Ile  Gln Thr Ile Gln Pro  Ser Leu Asn Ser Val  Asn Glu Gly 
    1100                 1105                 1110             


Gly Gln  Lys Ile Lys Ser Glu  Ala Glu Leu Glu Phe  Ala Ser Arg 
    1115                 1120                 1125             


Leu Glu  Thr Glu Leu Arg Glu  Leu Asn Thr Gln Trp  Asp His Ile 
    1130                 1135                 1140             


Cys Arg  Gln Val Tyr Thr Arg  Lys Glu Ala Leu Lys  Ala Gly Leu 
    1145                 1150                 1155             


Asp Lys  Thr Val Ser Leu Gln  Lys Asp Leu Ser Glu  Met His Glu 
    1160                 1165                 1170             


Trp Met  Thr Gln Ala Glu Glu  Glu Tyr Leu Glu Arg  Asp Phe Glu 
    1175                 1180                 1185             


Tyr Lys  Thr Pro Asp Glu Leu  Gln Thr Ala Val Glu  Glu Met Lys 
    1190                 1195                 1200             


Arg Ala  Lys Glu Glu Ala Leu  Gln Lys Glu Thr Lys  Val Lys Leu 
    1205                 1210                 1215             


Leu Thr  Glu Thr Val Asn Ser  Val Ile Ala His Ala  Pro Pro Ser 
    1220                 1225                 1230             


Ala Gln  Glu Ala Leu Lys Lys  Glu Leu Glu Thr Leu  Thr Thr Asn 
    1235                 1240                 1245             


Tyr Gln  Trp Leu Cys Thr Arg  Leu Asn Gly Lys Cys  Lys Thr Leu 
    1250                 1255                 1260             


Glu Glu  Val Trp Ala Cys Trp  His Glu Leu Leu Ser  Tyr Leu Glu 
    1265                 1270                 1275             


Lys Ala  Asn Lys Trp Leu Asn  Glu Val Glu Leu Lys  Leu Lys Thr 
    1280                 1285                 1290             


Met Glu  Asn Val Pro Ala Gly  Pro Glu Glu Ile Thr  Glu Val Leu 
    1295                 1300                 1305             


Glu Ser  Leu Glu Asn Leu Met  His His Ser Glu Glu  Asn Pro Asn 
    1310                 1315                 1320             


Gln Ile  Arg Leu Leu Ala Gln  Thr Leu Thr Asp Gly  Gly Val Met 
    1325                 1330                 1335             


Asp Glu  Leu Ile Asn Glu Glu  Leu Glu Thr Phe Asn  Ser Arg Trp 
    1340                 1345                 1350             


Arg Glu  Leu His Glu Glu Ala  Val Arg Lys Gln Lys  Leu Leu Glu 
    1355                 1360                 1365             


Gln Ser  Ile Gln Ser Ala Gln  Glu Ile Glu Lys Ser  Leu His Leu 
    1370                 1375                 1380             


Ile Gln  Glu Ser Leu Glu Phe  Ile Asp Lys Gln Leu  Ala Ala Tyr 
    1385                 1390                 1395             


Ile Thr  Asp Lys Val Asp Ala  Ala Gln Met Pro Gln  Glu Ala Gln 
    1400                 1405                 1410             


Lys Ile  Gln Ser Asp Leu Thr  Ser His Glu Ile Ser  Leu Glu Glu 
    1415                 1420                 1425             


Met Lys  Lys His Asn Gln Gly  Lys Asp Ala Asn Gln  Arg Val Leu 
    1430                 1435                 1440             


Ser Gln  Ile Asp Val Ala Gln  Lys Lys Leu Gln Asp  Val Ser Met 
    1445                 1450                 1455             


Lys Phe  Arg Leu Phe Gln Lys  Pro Ala Asn Phe Glu  Gln Arg Leu 
    1460                 1465                 1470             


Glu Glu  Ser Lys Met Ile Leu  Asp Glu Val Lys Met  His Leu Pro 
    1475                 1480                 1485             


Ala Leu  Glu Thr Lys Ser Val  Glu Gln Glu Val Ile  Gln Ser Gln 
    1490                 1495                 1500             


Leu Ser  His Cys Val Asn Leu  Tyr Lys Ser Leu Ser  Glu Val Lys 
    1505                 1510                 1515             


Ser Glu  Val Glu Met Val Ile  Lys Thr Gly Arg Gln  Ile Val Gln 
    1520                 1525                 1530             


Lys Lys  Gln Thr Glu Asn Pro  Lys Glu Leu Asp Glu  Arg Val Thr 
    1535                 1540                 1545             


Ala Leu  Lys Leu His Tyr Asn  Glu Leu Gly Ala Lys  Val Thr Glu 
    1550                 1555                 1560             


Arg Lys  Gln Gln Leu Glu Lys  Cys Leu Lys Leu Ser  Arg Lys Met 
    1565                 1570                 1575             


Arg Lys  Glu Met Asn Val Leu  Thr Glu Trp Leu Ala  Ala Thr Asp 
    1580                 1585                 1590             


Thr Glu  Leu Thr Lys Arg Ser  Ala Val Glu Gly Met  Pro Ser Asn 
    1595                 1600                 1605             


Leu Asp  Ser Glu Val Ala Trp  Gly Lys Ala Thr Gln  Lys Glu Ile 
    1610                 1615                 1620             


Glu Lys  Gln Lys Ala His Leu  Lys Ser Val Thr Glu  Leu Gly Glu 
    1625                 1630                 1635             


Ser Leu  Lys Met Val Leu Gly  Lys Lys Glu Thr Leu  Val Glu Asp 
    1640                 1645                 1650             


Lys Leu  Ser Leu Leu Asn Ser  Asn Trp Ile Ala Val  Thr Ser Arg 
    1655                 1660                 1665             


Val Glu  Glu Trp Leu Asn Leu  Leu Leu Glu Tyr Gln  Lys His Met 
    1670                 1675                 1680             


Glu Thr  Phe Asp Gln Asn Ile  Glu Gln Ile Thr Lys  Trp Ile Ile 
    1685                 1690                 1695             


His Ala  Asp Glu Leu Leu Asp  Glu Ser Glu Lys Lys  Lys Pro Gln 
    1700                 1705                 1710             


Gln Lys  Glu Asp Ile Leu Lys  Arg Leu Lys Ala Glu  Met Asn Asp 
    1715                 1720                 1725             


Met Arg  Pro Lys Val Asp Ser  Thr Arg Asp Gln Ala  Ala Lys Leu 
    1730                 1735                 1740             


Met Ala  Asn Arg Gly Asp His  Cys Arg Lys Val Val  Glu Pro Gln 
    1745                 1750                 1755             


Ile Ser  Glu Leu Asn Arg Arg  Phe Ala Ala Ile Ser  His Arg Ile 
    1760                 1765                 1770             


Lys Thr  Gly Lys Ala Ser Ile  Pro Leu Lys Glu Leu  Glu Gln Phe 
    1775                 1780                 1785             


Asn Ser  Asp Ile Gln Lys Leu  Leu Glu Pro Leu Glu  Ala Glu Ile 
    1790                 1795                 1800             


Gln Gln  Gly Val Asn Leu Lys  Glu Glu Asp Phe Asn  Lys Asp Met 
    1805                 1810                 1815             


Ser Glu  Asp Asn Glu Gly Thr  Val Asn Glu Leu Leu  Gln Arg Gly 
    1820                 1825                 1830             


Asp Asn  Leu Gln Gln Arg Ile  Thr Asp Glu Arg Lys  Arg Glu Glu 
    1835                 1840                 1845             


Ile Lys  Ile Lys Gln Gln Leu  Leu Gln Thr Lys His  Asn Ala Leu 
    1850                 1855                 1860             


Lys Asp  Leu Arg Ser Gln Arg  Arg Lys Lys Ala Leu  Glu Ile Ser 
    1865                 1870                 1875             


His Gln  Trp Tyr Gln Tyr Lys  Arg Gln Ala Asp Asp  Leu Leu Lys 
    1880                 1885                 1890             


Cys Leu  Asp Glu Ile Glu Lys  Lys Leu Ala Ser Leu  Pro Glu Pro 
    1895                 1900                 1905             


Arg Asp  Glu Arg Lys Leu Lys  Glu Ile Asp Arg Glu  Leu Gln Lys 
    1910                 1915                 1920             


Lys Lys  Glu Glu Leu Asn Ala  Val Arg Arg Gln Ala  Glu Gly Leu 
    1925                 1930                 1935             


Ser Glu  Asn Gly Ala Ala Met  Ala Val Glu Pro Thr  Gln Ile Gln 
    1940                 1945                 1950             


Leu Ser  Lys Arg Trp Arg Gln  Ile Glu Ser Asn Phe  Ala Gln Phe 
    1955                 1960                 1965             


Arg Arg  Leu Asn Phe Ala Gln  Ile His Thr Leu His  Glu Glu Thr 
    1970                 1975                 1980             


Met Val  Val Thr Thr Glu Asp  Met Pro Leu Asp Val  Ser Tyr Val 
    1985                 1990                 1995             


Pro Ser  Thr Tyr Leu Thr Glu  Ile Ser His Ile Leu  Gln Ala Leu 
    2000                 2005                 2010             


Ser Glu  Val Asp His Leu Leu  Asn Thr Pro Glu Leu  Cys Ala Lys 
    2015                 2020                 2025             


Asp Phe  Glu Asp Leu Phe Lys  Gln Glu Glu Ser Leu  Lys Asn Ile 
    2030                 2035                 2040             


Lys Asp  Asn Leu Gln Gln Ile  Ser Gly Arg Ile Asp  Ile Ile His 
    2045                 2050                 2055             


Lys Lys  Lys Thr Ala Ala Leu  Gln Ser Ala Thr Ser  Met Glu Lys 
    2060                 2065                 2070             


Val Lys  Val Gln Glu Ala Val  Ala Gln Met Asp Phe  Gln Gly Glu 
    2075                 2080                 2085             


Lys Leu  His Arg Met Tyr Lys  Glu Arg Gln Gly Arg  Phe Asp Arg 
    2090                 2095                 2100             


Ser Val  Glu Lys Trp Arg His  Phe His Tyr Asp Met  Lys Val Phe 
    2105                 2110                 2115             


Asn Gln  Trp Leu Asn Glu Val  Glu Gln Phe Phe Lys  Lys Thr Gln 
    2120                 2125                 2130             


Asn Pro  Glu Asn Trp Glu His  Ala Lys Tyr Lys Trp  Tyr Leu Lys 
    2135                 2140                 2145             


Glu Leu  Gln Asp Gly Ile Gly  Gln Arg Gln Ala Val  Val Arg Thr 
    2150                 2155                 2160             


Leu Asn  Ala Thr Gly Glu Glu  Ile Ile Gln Gln Ser  Ser Lys Thr 
    2165                 2170                 2175             


Asp Val  Asn Ile Leu Gln Glu  Lys Leu Gly Ser Leu  Ser Leu Arg 
    2180                 2185                 2190             


Trp His  Asp Ile Cys Lys Glu  Leu Ala Glu Arg Arg  Lys Arg Ile 
    2195                 2200                 2205             


Glu Glu  Gln Lys Asn Val Leu  Ser Glu Phe Gln Arg  Asp Leu Asn 
    2210                 2215                 2220             


Glu Phe  Val Leu Trp Leu Glu  Glu Ala Asp Asn Ile  Ala Ile Thr 
    2225                 2230                 2235             


Pro Leu  Gly Asp Glu Gln Gln  Leu Lys Glu Gln Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Ala Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Ala Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Arg Pro  Glu Glu Gln Asp Lys  Leu Glu Lys Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Leu Glu Val His Leu  Lys Asp Phe Arg Gln  Leu Glu Glu 
    2315                 2320                 2325             


Gln Leu  Asp His Leu Leu Leu  Trp Leu Ser Pro Ile  Arg Asn Gln 
    2330                 2335                 2340             


Leu Glu  Ile Tyr Asn Gln Pro  Ser Gln Ala Gly Pro  Phe Asp Ile 
    2345                 2350                 2355             


Lys Glu  Ile Glu Val Thr Val  His Gly Lys Gln Ala  Asp Val Glu 
    2360                 2365                 2370             


Arg Leu  Leu Ser Lys Gly Gln  His Leu Tyr Lys Glu  Lys Pro Ser 
    2375                 2380                 2385             


Thr Gln  Pro Val Lys Arg Lys  Leu Glu Asp Leu Arg  Ser Glu Trp 
    2390                 2395                 2400             


Glu Ala  Val Asn His Leu Leu  Arg Glu Leu Arg Thr  Lys Gln Pro 
    2405                 2410                 2415             


Asp Arg  Ala Pro Gly Leu Ser  Thr Thr Gly Ala Ser  Ala Ser Gln 
    2420                 2425                 2430             


Thr Val  Thr Leu Val Thr Gln  Ser Val Val Thr Lys  Glu Thr Val 
    2435                 2440                 2445             


Ile Ser  Lys Leu Glu Met Pro  Ser Ser Leu Leu Leu  Glu Val Pro 
    2450                 2455                 2460             


Ala Leu  Ala Asp Phe Asn Arg  Ala Trp Thr Glu Leu  Thr Asp Trp 
    2465                 2470                 2475             


Leu Ser  Leu Leu Asp Arg Val  Ile Lys Ser Gln Arg  Val Met Val 
    2480                 2485                 2490             


Gly Asp  Leu Glu Asp Ile Asn  Glu Met Ile Ile Lys  Gln Lys Ala 
    2495                 2500                 2505             


Thr Leu  Gln Asp Leu Glu Gln  Arg Arg Pro Gln Leu  Glu Glu Leu 
    2510                 2515                 2520             


Ile Thr  Ala Ala Gln Asn Leu  Lys Asn Lys Thr Ser  Asn Gln Glu 
    2525                 2530                 2535             


Ala Arg  Thr Ile Ile Thr Asp  Arg Ile Glu Arg Ile  Gln Ile Gln 
    2540                 2545                 2550             


Trp Asp  Glu Val Gln Glu Gln  Leu Gln Asn Arg Arg  Gln Gln Leu 
    2555                 2560                 2565             


Asn Glu  Met Leu Lys Asp Ser  Thr Gln Trp Leu Glu  Ala Lys Glu 
    2570                 2575                 2580             


Glu Ala  Glu Gln Val Ile Gly  Gln Val Arg Gly Lys  Leu Asp Ser 
    2585                 2590                 2595             


Trp Lys  Glu Gly Pro His Thr  Val Asp Ala Ile Gln  Lys Lys Ile 
    2600                 2605                 2610             


Thr Glu  Thr Lys Gln Leu Ala  Lys Asp Leu Arg Gln  Arg Gln Ile 
    2615                 2620                 2625             


Ser Val  Asp Val Ala Asn Asp  Leu Ala Leu Lys Leu  Leu Arg Asp 
    2630                 2635                 2640             


Tyr Ser  Ala Asp Asp Thr Arg  Lys Val His Met Ile  Thr Glu Asn 
    2645                 2650                 2655             


Ile Asn  Thr Ser Trp Gly Asn  Ile His Lys Arg Val  Ser Glu Gln 
    2660                 2665                 2670             


Glu Ala  Ala Leu Glu Glu Thr  His Arg Leu Leu Gln  Gln Phe Pro 
    2675                 2680                 2685             


Leu Asp  Leu Glu Lys Phe Leu  Ser Trp Ile Thr Glu  Ala Glu Thr 
    2690                 2695                 2700             


Thr Ala  Asn Val Leu Gln Asp  Ala Ser Arg Lys Glu  Lys Leu Leu 
    2705                 2710                 2715             


Glu Asp  Ser Arg Gly Val Arg  Glu Leu Met Lys Pro  Trp Gln Asp 
    2720                 2725                 2730             


Leu Gln  Gly Glu Ile Glu Thr  His Thr Asp Ile Tyr  His Asn Leu 
    2735                 2740                 2745             


Asp Glu  Asn Gly Gln Lys Ile  Leu Arg Ser Leu Glu  Gly Ser Asp 
    2750                 2755                 2760             


Glu Ala  Pro Leu Leu Gln Arg  Arg Leu Asp Asn Met  Asn Phe Lys 
    2765                 2770                 2775             


Trp Ser  Glu Leu Gln Lys Lys  Ser Leu Asn Ile Arg  Ser His Leu 
    2780                 2785                 2790             


Glu Ala  Ser Ser Asp Gln Trp  Lys Arg Leu His Leu  Ser Leu Gln 
    2795                 2800                 2805             


Glu Leu  Leu Val Trp Leu Gln  Leu Lys Asp Asp Glu  Leu Ser Arg 
    2810                 2815                 2820             


Gln Ala  Pro Ile Gly Gly Asp  Phe Pro Ala Val Gln  Lys Gln Asn 
    2825                 2830                 2835             


Asp Ile  His Arg Ala Phe Lys  Arg Glu Leu Lys Thr  Lys Glu Pro 
    2840                 2845                 2850             


Val Ile  Met Ser Thr Leu Glu  Thr Val Arg Ile Phe  Leu Thr Glu 
    2855                 2860                 2865             


Gln Pro  Leu Glu Gly Leu Glu  Lys Leu Tyr Gln Glu  Pro Arg Glu 
    2870                 2875                 2880             


Leu Pro  Pro Glu Glu Arg Ala  Gln Asn Val Thr Arg  Leu Leu Arg 
    2885                 2890                 2895             


Lys Gln  Ala Glu Glu Val Asn  Ala Glu Trp Asp Lys  Leu Asn Leu 
    2900                 2905                 2910             


Arg Ser  Ala Asp Trp Gln Arg  Lys Ile Asp Glu Ala  Leu Glu Arg 
    2915                 2920                 2925             


Leu Gln  Glu Leu Gln Glu Ala  Ala Asp Glu Leu Asp  Leu Lys Leu 
    2930                 2935                 2940             


Arg Gln  Ala Glu Val Ile Lys  Gly Ser Trp Gln Pro  Val Gly Asp 
    2945                 2950                 2955             


Leu Leu  Ile Asp Ser Leu Gln  Asp His Leu Glu Lys  Val Lys Ala 
    2960                 2965                 2970             


Leu Arg  Gly Glu Ile Ala Pro  Leu Lys Glu Asn Val  Asn Arg Val 
    2975                 2980                 2985             


Asn Asp  Leu Ala His Gln Leu  Thr Thr Leu Gly Ile  Gln Leu Ser 
    2990                 2995                 3000             


Pro Tyr  Asn Leu Ser Thr Leu  Glu Asp Leu Asn Thr  Arg Trp Arg 
    3005                 3010                 3015             


Leu Leu  Gln Val Ala Val Glu  Asp Arg Val Arg Gln  Leu His Glu 
    3020                 3025                 3030             


Ala His  Arg Asp Phe Gly Pro  Ala Ser Gln His Phe  Leu Ser Thr 
    3035                 3040                 3045             


Ser Val  Gln Gly Pro Trp Glu  Arg Ala Ile Ser Pro  Asn Lys Val 
    3050                 3055                 3060             


Pro Tyr  Tyr Ile Asn His Glu  Thr Gln Thr Thr Cys  Trp Asp His 
    3065                 3070                 3075             


Pro Lys  Met Thr Glu Leu Tyr  Gln Ser Leu Ala Asp  Leu Asn Asn 
    3080                 3085                 3090             


Val Arg  Phe Ser Ala Tyr Arg  Thr Ala Met Lys Leu  Arg Arg Leu 
    3095                 3100                 3105             


Gln Lys  Ala Leu Cys Leu Asp  Leu Leu Ser Leu Ser  Ala Ala Cys 
    3110                 3115                 3120             


Asp Ala  Leu Asp Gln His Asn  Leu Lys Gln Asn Asp  Gln Pro Met 
    3125                 3130                 3135             


Asp Ile  Leu Gln Ile Ile Asn  Cys Leu Thr Thr Ile  Tyr Asp Arg 
    3140                 3145                 3150             


Leu Glu  Gln Glu His Asn Asn  Leu Val Asn Val Pro  Leu Cys Val 
    3155                 3160                 3165             


Asp Met  Cys Leu Asn Trp Leu  Leu Asn Val Tyr Asp  Thr Gly Arg 
    3170                 3175                 3180             


Thr Gly  Arg Ile Arg Val Leu  Ser Phe Lys Thr Gly  Ile Ile Ser 
    3185                 3190                 3195             


Leu Cys  Lys Ala His Leu Glu  Asp Lys Tyr Arg Tyr  Leu Phe Lys 
    3200                 3205                 3210             


Gln Val  Ala Ser Ser Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly 
    3215                 3220                 3225             


Leu Leu  Leu His Asp Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu 
    3230                 3235                 3240             


Val Ala  Ser Phe Gly Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser 
    3245                 3250                 3255             


Cys Phe  Gln Phe Ala Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu 
    3260                 3265                 3270             


Phe Leu  Asp Trp Met Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu 
    3275                 3280                 3285             


Pro Val  Leu His Arg Val Ala  Ala Ala Glu Thr Ala  Lys His Gln 
    3290                 3295                 3300             


Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg 
    3305                 3310                 3315             


Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys 
    3320                 3325                 3330             


Phe Phe  Ser Gly Arg Val Ala  Lys Gly His Lys Met  His Tyr Pro 
    3335                 3340                 3345             


Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg 
    3350                 3355                 3360             


Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr 
    3365                 3370                 3375             


Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val 
    3380                 3385                 3390             


Leu Glu  Gly Asp Asn Met Glu  Thr Pro Val Thr Leu  Ile Asn Phe 
    3395                 3400                 3405             


Trp Pro  Val Asp Ser Ala Pro  Ala Ser Ser Pro Gln  Leu Ser His 
    3410                 3415                 3420             


Asp Asp  Thr His Ser Arg Ile  Glu His Tyr Ala Ser  Arg Leu Ala 
    3425                 3430                 3435             


Glu Met  Glu Asn Ser Asn Gly  Ser Tyr Leu Asn Asp  Ser Ile Ser 
    3440                 3445                 3450             


Pro Asn  Glu Ser Ile Asp Asp  Glu His Leu Leu Ile  Gln His Tyr 
    3455                 3460                 3465             


Cys Gln  Ser Leu Asn Gln Asp  Ser Pro Leu Ser Gln  Pro Arg Ser 
    3470                 3475                 3480             


Pro Ala  Gln Ile Leu Ile Ser  Leu Glu Ser Glu Glu  Arg Gly Glu 
    3485                 3490                 3495             


Leu Glu  Arg Ile Leu Ala Asp  Leu Glu Glu Glu Asn  Arg Asn Leu 
    3500                 3505                 3510             


Gln Ala  Glu Tyr Asp Arg Leu  Lys Gln Gln His Glu  His Lys Gly 
    3515                 3520                 3525             


Leu Ser  Pro Leu Pro Ser Pro  Pro Glu Met Met Pro  Thr Ser Pro 
    3530                 3535                 3540             


Gln Ser  Pro Arg Asp Ala Glu  Leu Ile Ala Glu Ala  Lys Leu Leu 
    3545                 3550                 3555             


Arg Gln  His Lys Gly Arg Leu  Glu Ala Arg Met Gln  Ile Leu Glu 
    3560                 3565                 3570             


Asp His  Asn Lys Gln Leu Glu  Ser Gln Leu His Arg  Leu Arg Gln 
    3575                 3580                 3585             


Leu Leu  Glu Gln Pro Gln Ala  Glu Ala Lys Val Asn  Gly Thr Thr 
    3590                 3595                 3600             


Val Ser  Ser Pro Ser Thr Ser  Leu Gln Arg Ser Asp  Ser Ser Gln 
    3605                 3610                 3615             


Pro Met  Leu Leu Arg Val Val  Gly Ser Gln Thr Ser  Glu Ser Met 
    3620                 3625                 3630             


Gly Glu  Glu Asp Leu Leu Ser  Pro Pro Gln Asp Thr  Ser Thr Gly 
    3635                 3640                 3645             


Leu Glu  Glu Val Met Glu Gln  Leu Asn Asn Ser Phe  Pro Ser Ser 
    3650                 3655                 3660             


Arg Gly  Arg Asn Ala Pro Gly  Lys Pro Met Arg Glu  Asp Thr Met 
    3665                 3670                 3675             


<210>  3
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu 
1               5                   10                  15      


His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln 
            20                  25                  30          


Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala 
        35                  40                  45              


Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro 
    50                  55                  60                  


Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp 
65                  70                  75  


<210>  4
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Leu Pro Arg Thr Ser Ser Lys Val Thr Arg Glu Glu His Phe Gln 
1               5                   10                  15      


Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala 
            20                  25                  30          


Gln Gly Tyr Glu Gln Thr Ser Ser Ser Pro Lys Pro Arg Phe Lys Ser 
        35                  40                  45              


Tyr Ala Phe Thr Gln Ala Ala Tyr Val Ala Thr Ser Asp Ser Thr Gln 
    50                  55                  60                  


Ser Pro Tyr Pro Ser Gln His Leu Glu Ala Pro Arg Asp 
65                  70                  75          


<210>  5
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  6
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  7
<211>  3210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaaagt catttggcag ttcattgatg      780

gagagtgaag taaacctgga ccgttatcaa acagctttag aagaagtatt atcgtggctt      840

ctttctgctg aggacacatt gcaagcacaa ggagagattt ctaatgatgt ggaagtggtg      900

aaagaccagt ttcatactca tgaggggtac atgatggatt tgacagccca tcagggccgg      960

gttggtaata ttctacaatt gggaagtaag ctgattggaa caggaaaatt atcagaagat     1020

gaagaaactg aagtacaaga gcagatgaat ctcctaaatt caagatggga atgcctcagg     1080

gtagctagca tggaaaaaca aagcaattta catagagaaa tttcttatgt gccttctact     1140

tatttgactg aaatcactca tgtctcacaa gccctattag aagtggaaca acttctcaat     1200

gctcctgacc tctgtgctaa ggactttgaa gatctcttta agcaagagga gtctctgaag     1260

aatataaaag atagtctaca acaaagctca ggtcggattg acattattca tagcaagaag     1320

acagcagcat tgcaaagtgc aacgcctgtg gaaagggtga agctacagga agctctctcc     1380

cagcttgatt tccaatggga aaaagttaac aaaatgtaca aggaccgaca agggcgattt     1440

gacagatctg ttgagaaatg gcggcgtttt cattatgata taaagatatt taatcagtgg     1500

ctaacagaag ctgaacagtt tctcagaaag acacaaattc ctgagaattg ggaacatgct     1560

aaatacaaat ggtatcttaa ggaactccag gatggcattg ggcagcggca aactgttgtc     1620

agaacattga atgcaactgg ggaagaaata attcagcaat cctcaaaaac agatgccagt     1680

attctacagg aaaaattggg aagcctgaat ctgcggtggc aggaggtctg caaacagctg     1740

tcagacagaa aaaagaggct agaagaaacc cttgaaagac tccaggaact tcaagaggcc     1800

acggatgagc tggacctcaa gctgcgccaa gctgaggtga tcaagggatc ctggcagccc     1860

gtgggcgatc tcctcattga ctctctccaa gatcacctcg agaaagtcaa ggcacttcga     1920

ggagaaattg cgcctctgaa agagaacgtg agccacgtca atgaccttgc tcgccagctt     1980

accactttgg gcattcagct ctcaccgtat aacctcagca ctctggaaga cctgaacacc     2040

agatggaagc ttctgcaggt ggccgtcgag gaccgagtca ggcagctgca tgaagcccac     2100

agggactttg gtccagcatc tcagcacttt ctttccacgt ctgtccaggg tccctgggag     2160

agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca aacaacttgc     2220

tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga     2280

ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat     2340

ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac     2400

cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag     2460

caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg     2520

ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc     2580

atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg     2640

gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc     2700

caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt     2760

gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta     2820

gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct     2880

gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt     2940

ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt     3000

tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg     3060

actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     3120

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag     3180

ggggacaaca tggaaactga cacaatgtag                                      3210


<210>  8
<211>  1069
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Lys Ser Phe Gly 
                245                 250                 255     


Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala 
            260                 265                 270         


Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln 
        275                 280                 285             


Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe 
    290                 295                 300                 


His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg 
305                 310                 315                 320 


Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys 
                325                 330                 335     


Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu 
            340                 345                 350         


Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser 
        355                 360                 365             


Asn Leu His Arg Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
    370                 375                 380                 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
385                 390                 395                 400 


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
                405                 410                 415     


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
            420                 425                 430         


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
        435                 440                 445             


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
    450                 455                 460                 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
465                 470                 475                 480 


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
                485                 490                 495     


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
            500                 505                 510         


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
        515                 520                 525             


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
    530                 535                 540                 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
545                 550                 555                 560 


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
                565                 570                 575     


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu 
            580                 585                 590         


Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
        595                 600                 605             


Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
    610                 615                 620                 


Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
625                 630                 635                 640 


Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
                645                 650                 655     


Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
            660                 665                 670         


Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
        675                 680                 685             


Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly 
    690                 695                 700                 


Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu 
705                 710                 715                 720 


Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 
                725                 730                 735     


Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser 
            740                 745                 750         


Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met 
        755                 760                 765             


Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu 
    770                 775                 780                 


Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp 
785                 790                 795                 800 


Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr 
                805                 810                 815     


Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys 
            820                 825                 830         


Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg 
        835                 840                 845             


Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu 
    850                 855                 860                 


Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val 
865                 870                 875                 880 


Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu 
                885                 890                 895     


His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe 
            900                 905                 910         


Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala 
        915                 920                 925             


Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg 
    930                 935                 940                 


Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala 
945                 950                 955                 960 


Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 
                965                 970                 975     


Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr 
            980                 985                 990         


Asp Ile Cys Gln Ser Cys Phe Phe  Ser Gly Arg Val Ala  Lys Gly His 
        995                 1000                 1005             


Lys Met  His Tyr Pro Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser 
    1010                 1015                 1020             


Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe 
    1025                 1030                 1035             


Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu 
    1040                 1045                 1050             


Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn Met Glu  Thr Asp Thr 
    1055                 1060                 1065             


Met 
    


<210>  9
<211>  3219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agaaatttct tatgtgcctt ctacttattt gactgaaatc     1380

actcatgtct cacaagccct attagaagtg gaacaacttc tcaatgctcc tgacctctgt     1440

gctaaggact ttgaagatct ctttaagcaa gaggagtctc tgaagaatat aaaagatagt     1500

ctacaacaaa gctcaggtcg gattgacatt attcatagca agaagacagc agcattgcaa     1560

agtgcaacgc ctgtggaaag ggtgaagcta caggaagctc tctcccagct tgatttccaa     1620

tgggaaaaag ttaacaaaat gtacaaggac cgacaagggc gatttgacag atctgttgag     1680

aaatggcggc gttttcatta tgatataaag atatttaatc agtggctaac agaagctgaa     1740

cagtttctca gaaagacaca aattcctgag aattgggaac atgctaaata caaatggtat     1800

cttaaggaac tccaggatgg cattgggcag cggcaaactg ttgtcagaac attgaatgca     1860

actggggaag aaataattca gcaatcctca aaaacagatg ccagtattct acaggaaaaa     1920

ttgggaagcc tgaatctgcg gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag     1980

aggctagaag aaacccttga aagactccag gaacttcaag aggccacgga tgagctggac     2040

ctcaagctgc gccaagctga ggtgatcaag ggatcctggc agcccgtggg cgatctcctc     2100

attgactctc tccaagatca cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct     2160

ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc agcttaccac tttgggcatt     2220

cagctctcac cgtataacct cagcactctg gaagacctga acaccagatg gaagcttctg     2280

caggtggccg tcgaggaccg agtcaggcag ctgcatgaac gaagactgca gaaggccctt     2340

tgcttggatc tcttgagcct gtcagctgca tgtgatgcct tggaccagca caacctcaag     2400

caaaatgacc agcccatgga tatcctgcag attattaatt gtttgaccac tatttatgac     2460

cgcctggagc aagagcacaa caatttggtc aacgtccctc tctgcgtgga tatgtgtctg     2520

aactggctgc tgaatgttta tgatacggga cgaacaggga ggatccgtgt cctgtctttt     2580

aaaactggca tcatttccct gtgtaaagca catttggaag acaagtacag ataccttttc     2640

aagcaagtgg caagttcaac aggattttgt gaccagcgca ggctgggcct ccttctgcat     2700

gattctatcc aaattccaag acagttgggt gaagttgcat cctttggggg cagtaacatt     2760

gagccaagtg tccggagctg cttccaattt gctaataata agccagagat cgaagcggcc     2820

ctcttcctag actggatgag actggaaccc cagtccatgg tgtggctgcc cgtcctgcac     2880

agagtggctg ctgcagaaac tgccaagcat caggccaaat gtaacatctg caaagagtgt     2940

ccaatcattg gattcaggta caggagtcta aagcacttta attatgacat ctgccaaagc     3000

tgcttttttt ctggtcgagt tgcaaaaggc cataaaatgc actatcccat ggtggaatat     3060

tgcactccga ctacatcagg agaagatgtt cgagactttg ccaaggtact aaaaaacaaa     3120

tttcgaacca aaaggtattt tgcgaagcat ccccgaatgg gctacctgcc agtgcagact     3180

gtcttagagg gggacaacat ggaaactgac acaatgtag                            3219


<210>  10
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Glu 
        435                 440                 445             


Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
    450                 455                 460                 


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
465                 470                 475                 480 


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
                485                 490                 495     


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
            500                 505                 510         


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
        515                 520                 525             


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
    530                 535                 540                 


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
545                 550                 555                 560 


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
                565                 570                 575     


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
            580                 585                 590         


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
        595                 600                 605             


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
    610                 615                 620                 


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
625                 630                 635                 640 


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
                645                 650                 655     


Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu Arg Leu Gln Glu Leu 
            660                 665                 670         


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
        675                 680                 685             


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
    690                 695                 700                 


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
705                 710                 715                 720 


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
                725                 730                 735     


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
            740                 745                 750         


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
        755                 760                 765             


Arg Gln Leu His Glu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 
    770                 775                 780                 


Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys 
785                 790                 795                 800 


Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr 
                805                 810                 815     


Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val 
            820                 825                 830         


Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp 
        835                 840                 845             


Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile 
    850                 855                 860                 


Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe 
865                 870                 875                 880 


Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly 
                885                 890                 895     


Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val 
            900                 905                 910         


Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe 
        915                 920                 925             


Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp 
    930                 935                 940                 


Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His 
945                 950                 955                 960 


Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile 
                965                 970                 975     


Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His 
            980                 985                 990         


Phe Asn Tyr Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
        995                 1000                 1005             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1010                 1015                 1020             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1025                 1030                 1035             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1040                 1045                 1050             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1055                 1060                 1065             


Thr Asp  Thr Met 
    1070         


<210>  11
<211>  3390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agaaatttct tatgtgcctt ctacttattt gactgaaatc     1380

actcatgtct cacaagccct attagaagtg gaacaacttc tcaatgctcc tgacctctgt     1440

gctaaggact ttgaagatct ctttaagcaa gaggagtctc tgaagaatat aaaagatagt     1500

ctacaacaaa gctcaggtcg gattgacatt attcatagca agaagacagc agcattgcaa     1560

agtgcaacgc ctgtggaaag ggtgaagcta caggaagctc tctcccagct tgatttccaa     1620

tgggaaaaag ttaacaaaat gtacaaggac cgacaagggc gatttgacag atctgttgag     1680

aaatggcggc gttttcatta tgatataaag atatttaatc agtggctaac agaagctgaa     1740

cagtttctca gaaagacaca aattcctgag aattgggaac atgctaaata caaatggtat     1800

cttaaggaac tccaggatgg cattgggcag cggcaaactg ttgtcagaac attgaatgca     1860

actggggaag aaataattca gcaatcctca aaaacagatg ccagtattct acaggaaaaa     1920

ttgggaagcc tgaatctgcg gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag     1980

aggctagaag aaacccttga aagactccag gaacttcaag aggccacgga tgagctggac     2040

ctcaagctgc gccaagctga ggtgatcaag ggatcctggc agcccgtggg cgatctcctc     2100

attgactctc tccaagatca cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct     2160

ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc agcttaccac tttgggcatt     2220

cagctctcac cgtataacct cagcactctg gaagacctga acaccagatg gaagcttctg     2280

caggtggccg tcgaggaccg agtcaggcag ctgcatgaat ctgtccaggg tccctgggag     2340

agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca aacaacttgc     2400

tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga     2460

ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat     2520

ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac     2580

cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag     2640

caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg     2700

ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc     2760

atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg     2820

gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc     2880

caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt     2940

gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta     3000

gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct     3060

gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt     3120

ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt     3180

tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg     3240

actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     3300

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag     3360

ggggacaaca tggaaactga cacaatgtag                                      3390


<210>  12
<211>  1129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Glu 
        435                 440                 445             


Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
    450                 455                 460                 


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
465                 470                 475                 480 


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
                485                 490                 495     


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
            500                 505                 510         


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
        515                 520                 525             


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
    530                 535                 540                 


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
545                 550                 555                 560 


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
                565                 570                 575     


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
            580                 585                 590         


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
        595                 600                 605             


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
    610                 615                 620                 


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
625                 630                 635                 640 


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
                645                 650                 655     


Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu Arg Leu Gln Glu Leu 
            660                 665                 670         


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
        675                 680                 685             


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
    690                 695                 700                 


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
705                 710                 715                 720 


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
                725                 730                 735     


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
            740                 745                 750         


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
        755                 760                 765             


Arg Gln Leu His Glu Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
    770                 775                 780                 


Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
785                 790                 795                 800 


Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu 
                805                 810                 815     


Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg 
            820                 825                 830         


Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys 
        835                 840                 845             


Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 
    850                 855                 860                 


Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu 
865                 870                 875                 880 


Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys 
                885                 890                 895     


Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile 
            900                 905                 910         


Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His 
        915                 920                 925             


Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr 
    930                 935                 940                 


Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile 
945                 950                 955                 960 


Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 
                965                 970                 975     


Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro 
            980                 985                 990         


Glu Ile Glu Ala Ala Leu Phe Leu  Asp Trp Met Arg Leu  Glu Pro Gln 
        995                 1000                 1005             


Ser Met  Val Trp Leu Pro Val  Leu His Arg Val Ala  Ala Ala Glu 
    1010                 1015                 1020             


Thr Ala  Lys His Gln Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro 
    1025                 1030                 1035             


Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp 
    1040                 1045                 1050             


Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg Val Ala  Lys Gly His 
    1055                 1060                 1065             


Lys Met  His Tyr Pro Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser 
    1070                 1075                 1080             


Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe 
    1085                 1090                 1095             


Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu 
    1100                 1105                 1110             


Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn Met Glu  Thr Asp Thr 
    1115                 1120                 1125             


Met 
    


<210>  13
<211>  3375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agaaatttct tatgtgcctt ctacttattt gactgaaatc     1380

actcatgtct cacaagccct attagaagtg gaacaacttc tcaatgctcc tgacctctgt     1440

gctaaggact ttgaagatct ctttaagcaa gaggagtctc tgaagaatat aaaagatagt     1500

ctacaacaaa gctcaggtcg gattgacatt attcatagca agaagacagc agcattgcaa     1560

agtgcaacgc ctgtggaaag ggtgaagcta caggaagctc tctcccagct tgatttccaa     1620

tgggaaaaag ttaacaaaat gtacaaggac cgacaagggc gatttgacag atctgttgag     1680

aaatggcggc gttttcatta tgatataaag atatttaatc agtggctaac agaagctgaa     1740

cagtttctca gaaagacaca aattcctgag aattgggaac atgctaaata caaatggtat     1800

cttaaggaac tccaggatgg cattgggcag cggcaaactg ttgtcagaac attgaatgca     1860

actggggaag aaataattca gcaatcctca aaaacagatg ccagtattct acaggaaaaa     1920

ttgggaagcc tgaatctgcg gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag     1980

aggctagaag aaacccttga aagactccag gaacttcaag aggccacgga tgagctggac     2040

ctcaagctgc gccaagctga ggtgatcaag ggatcctggc agcccgtggg cgatctcctc     2100

attgactctc tccaagatca cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct     2160

ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc agcttaccac tttgggcatt     2220

cagctctcac cgtataacct cagcactctg gaagacctga acaccagatg gaagcttctg     2280

caggtggccg tcgaggaccg agtcaggcag ctgcatgaag cccacaggga ctttggtcca     2340

gcatctcagc actttctttc cacgtctgtc cagggtccct gggagagagc catctcgcca     2400

aacaaagtgc cctactatat caaccacgag actcaaacaa cttgctggga ccatcccaaa     2460

atgacagagc tctaccgaag actgcagaag gccctttgct tggatctctt gagcctgtca     2520

gctgcatgtg atgccttgga ccagcacaac ctcaagcaaa atgaccagcc catggatatc     2580

ctgcagatta ttaattgttt gaccactatt tatgaccgcc tggagcaaga gcacaacaat     2640

ttggtcaacg tccctctctg cgtggatatg tgtctgaact ggctgctgaa tgtttatgat     2700

acgggacgaa cagggaggat ccgtgtcctg tcttttaaaa ctggcatcat ttccctgtgt     2760

aaagcacatt tggaagacaa gtacagatac cttttcaagc aagtggcaag ttcaacagga     2820

ttttgtgacc agcgcaggct gggcctcctt ctgcatgatt ctatccaaat tccaagacag     2880

ttgggtgaag ttgcatcctt tgggggcagt aacattgagc caagtgtccg gagctgcttc     2940

caatttgcta ataataagcc agagatcgaa gcggccctct tcctagactg gatgagactg     3000

gaaccccagt ccatggtgtg gctgcccgtc ctgcacagag tggctgctgc agaaactgcc     3060

aagcatcagg ccaaatgtaa catctgcaaa gagtgtccaa tcattggatt caggtacagg     3120

agtctaaagc actttaatta tgacatctgc caaagctgct ttttttctgg tcgagttgca     3180

aaaggccata aaatgcacta tcccatggtg gaatattgca ctccgactac atcaggagaa     3240

gatgttcgag actttgccaa ggtactaaaa aacaaatttc gaaccaaaag gtattttgcg     3300

aagcatcccc gaatgggcta cctgccagtg cagactgtct tagaggggga caacatggaa     3360

actgacacaa tgtag                                                      3375


<210>  14
<211>  1124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Glu 
        435                 440                 445             


Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
    450                 455                 460                 


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
465                 470                 475                 480 


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
                485                 490                 495     


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
            500                 505                 510         


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
        515                 520                 525             


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
    530                 535                 540                 


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
545                 550                 555                 560 


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
                565                 570                 575     


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
            580                 585                 590         


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
        595                 600                 605             


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
    610                 615                 620                 


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
625                 630                 635                 640 


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
                645                 650                 655     


Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu Arg Leu Gln Glu Leu 
            660                 665                 670         


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
        675                 680                 685             


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
    690                 695                 700                 


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
705                 710                 715                 720 


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
                725                 730                 735     


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
            740                 745                 750         


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
        755                 760                 765             


Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His 
    770                 775                 780                 


Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 
785                 790                 795                 800 


Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp 
                805                 810                 815     


Asp His Pro Lys Met Thr Glu Leu Tyr Arg Arg Leu Gln Lys Ala Leu 
            820                 825                 830         


Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln 
        835                 840                 845             


His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile 
    850                 855                 860                 


Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn 
865                 870                 875                 880 


Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 
                885                 890                 895     


Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe 
            900                 905                 910         


Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr 
        915                 920                 925             


Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln 
    930                 935                 940                 


Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln 
945                 950                 955                 960 


Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val 
                965                 970                 975     


Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala 
            980                 985                 990         


Leu Phe Leu Asp Trp Met Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu 
        995                 1000                 1005             


Pro Val  Leu His Arg Val Ala  Ala Ala Glu Thr Ala  Lys His Gln 
    1010                 1015                 1020             


Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg 
    1025                 1030                 1035             


Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys 
    1040                 1045                 1050             


Phe Phe  Ser Gly Arg Val Ala  Lys Gly His Lys Met  His Tyr Pro 
    1055                 1060                 1065             


Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg 
    1070                 1075                 1080             


Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr 
    1085                 1090                 1095             


Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val 
    1100                 1105                 1110             


Leu Glu  Gly Asp Asn Met Glu  Thr Asp Thr Met 
    1115                 1120                 


<210>  15
<211>  3330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agaaatttct tatgtgcctt ctacttattt gactgaaatc     1380

actcatgtct cacaagccct attagaagtg gaacaacttc tcaatgctcc tgacctctgt     1440

gctaaggact ttgaagatct ctttaagcaa gaggagtctc tgaagaatat aaaagatagt     1500

ctacaacaaa gctcaggtcg gattgacatt attcatagca agaagacagc agcattgcaa     1560

agtgcaacgc ctgtggaaag ggtgaagcta caggaagctc tctcccagct tgatttccaa     1620

tgggaaaaag ttaacaaaat gtacaaggac cgacaagggc gatttgacag atctgttgag     1680

aaatggcggc gttttcatta tgatataaag atatttaatc agtggctaac agaagctgaa     1740

cagtttctca gaaagacaca aattcctgag aattgggaac atgctaaata caaatggtat     1800

cttaaggaac tccaggatgg cattgggcag cggcaaactg ttgtcagaac attgaatgca     1860

actggggaag aaataattca gcaatcctca aaaacagatg ccagtattct acaggaaaaa     1920

ttgggaagcc tgaatctgcg gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag     1980

aggctagaag aaacccttga aagactccag gaacttcaag aggccacgga tgagctggac     2040

ctcaagctgc gccaagctga ggtgatcaag ggatcctggc agcccgtggg cgatctcctc     2100

attgactctc tccaagatca cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct     2160

ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc agcttaccac tttgggcatt     2220

cagctctcac cgtataacct cagcactctg gaagacctga acaccagatg gaagcttctg     2280

caggtggccg tcgaggaccg agtcaggcag ctgcatgaat ctgtccaggg tccctgggag     2340

agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca aacaacttgc     2400

tgggaccatc ccaaaatgac agagctctac cgaagactgc agaaggccct ttgcttggat     2460

ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac     2520

cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag     2580

caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg     2640

ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc     2700

atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg     2760

gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc     2820

caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt     2880

gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta     2940

gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct     3000

gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt     3060

ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt     3120

tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg     3180

actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     3240

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag     3300

ggggacaaca tggaaactga cacaatgtag                                      3330


<210>  16
<211>  1109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Glu 
        435                 440                 445             


Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
    450                 455                 460                 


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
465                 470                 475                 480 


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
                485                 490                 495     


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
            500                 505                 510         


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
        515                 520                 525             


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
    530                 535                 540                 


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
545                 550                 555                 560 


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
                565                 570                 575     


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
            580                 585                 590         


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
        595                 600                 605             


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
    610                 615                 620                 


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
625                 630                 635                 640 


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
                645                 650                 655     


Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu Arg Leu Gln Glu Leu 
            660                 665                 670         


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
        675                 680                 685             


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
    690                 695                 700                 


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
705                 710                 715                 720 


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
                725                 730                 735     


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
            740                 745                 750         


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
        755                 760                 765             


Arg Gln Leu His Glu Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
    770                 775                 780                 


Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
785                 790                 795                 800 


Trp Asp His Pro Lys Met Thr Glu Leu Tyr Arg Arg Leu Gln Lys Ala 
                805                 810                 815     


Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp 
            820                 825                 830         


Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile 
        835                 840                 845             


Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn 
    850                 855                 860                 


Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu 
865                 870                 875                 880 


Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 
                885                 890                 895     


Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys 
            900                 905                 910         


Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp 
        915                 920                 925             


Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg 
    930                 935                 940                 


Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser 
945                 950                 955                 960 


Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala 
                965                 970                 975     


Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp 
            980                 985                 990         


Leu Pro Val Leu His Arg Val Ala  Ala Ala Glu Thr Ala  Lys His Gln 
        995                 1000                 1005             


Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg 
    1010                 1015                 1020             


Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys 
    1025                 1030                 1035             


Phe Phe  Ser Gly Arg Val Ala  Lys Gly His Lys Met  His Tyr Pro 
    1040                 1045                 1050             


Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg 
    1055                 1060                 1065             


Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr 
    1070                 1075                 1080             


Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val 
    1085                 1090                 1095             


Leu Glu  Gly Asp Asn Met Glu  Thr Asp Thr Met 
    1100                 1105                 


<210>  17
<211>  3270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agaaatttct tatgtgcctt ctacttattt gactgaaatc     1380

actcatgtct cacaagccct attagaagtg gaacaacttc tcaatgctcc tgacctctgt     1440

gctaaggact ttgaagatct ctttaagcaa gaggagtctc tgaagaatat aaaagatagt     1500

ctacaacaaa gctcaggtcg gattgacatt attcatagca agaagacagc agcattgcaa     1560

agtgcaacgc ctgtggaaag ggtgaagcta caggaagctc tctcccagct tgatttccaa     1620

tgggaaaaag ttaacaaaat gtacaaggac cgacaagggc gatttgacag atctgttgag     1680

aaatggcggc gttttcatta tgatataaag atatttaatc agtggctaac agaagctgaa     1740

cagtttctca gaaagacaca aattcctgag aattgggaac atgctaaata caaatggtat     1800

cttaaggaac tccaggatgg cattgggcag cggcaaactg ttgtcagaac attgaatgca     1860

actggggaag aaataattca gcaatcctca aaaacagatg ccagtattct acaggaaaaa     1920

ttgggaagcc tgaatctgcg gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag     1980

aggctagaag aaacccttga aagactccag gaacttcaag aggccacgga tgagctggac     2040

ctcaagctgc gccaagctga ggtgatcaag ggatcctggc agcccgtggg cgatctcctc     2100

attgactctc tccaagatca cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct     2160

ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc agcttaccac tttgggcatt     2220

cagctctcac cgtataacct cagcactctg gaagacctga acaccagatg gaagcttctg     2280

caggtggccg tcgaggaccg agtcaggcag ctgcatgaac acgagactca aacaacttgc     2340

tgggaccatc ccaaaatgac agagctctac cgaagactgc agaaggccct ttgcttggat     2400

ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac     2460

cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag     2520

caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg     2580

ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc     2640

atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg     2700

gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc     2760

caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt     2820

gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta     2880

gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct     2940

gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt     3000

ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt     3060

tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg     3120

actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     3180

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag     3240

ggggacaaca tggaaactga cacaatgtag                                      3270


<210>  18
<211>  1089
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Glu 
        435                 440                 445             


Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser 
    450                 455                 460                 


Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 
465                 470                 475                 480 


Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn 
                485                 490                 495     


Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His 
            500                 505                 510         


Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val 
        515                 520                 525             


Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 
    530                 535                 540                 


Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 
545                 550                 555                 560 


Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu 
                565                 570                 575     


Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp 
            580                 585                 590         


Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 
        595                 600                 605             


Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu 
    610                 615                 620                 


Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys 
625                 630                 635                 640 


Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser 
                645                 650                 655     


Asp Arg Lys Lys Arg Leu Glu Glu Thr Leu Glu Arg Leu Gln Glu Leu 
            660                 665                 670         


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
        675                 680                 685             


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
    690                 695                 700                 


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
705                 710                 715                 720 


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
                725                 730                 735     


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
            740                 745                 750         


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
        755                 760                 765             


Arg Gln Leu His Glu His Glu Thr Gln Thr Thr Cys Trp Asp His Pro 
    770                 775                 780                 


Lys Met Thr Glu Leu Tyr Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp 
785                 790                 795                 800 


Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 
                805                 810                 815     


Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu 
            820                 825                 830         


Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn 
        835                 840                 845             


Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr 
    850                 855                 860                 


Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly 
865                 870                 875                 880 


Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu 
                885                 890                 895     


Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu 
            900                 905                 910         


Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu 
        915                 920                 925             


Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys 
    930                 935                 940                 


Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu 
945                 950                 955                 960 


Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu 
                965                 970                 975     


His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn 
            980                 985                 990         


Ile Cys Lys Glu Cys Pro Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys 
        995                 1000                 1005             


His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg 
    1010                 1015                 1020             


Val Ala  Lys Gly His Lys Met  His Tyr Pro Met Val  Glu Tyr Cys 
    1025                 1030                 1035             


Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val 
    1040                 1045                 1050             


Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro 
    1055                 1060                 1065             


Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn 
    1070                 1075                 1080             


Met Glu  Thr Asp Thr Met 
    1085                 


