                         SEQUENCE LISTING

<110>  Capienda Biotech, LLC
       Bernard, Mark A.
       Tachado, Souvenir D.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES

<130>  125777-001WO1

<150>  US 62/651,621
<151>  2018-04-02

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Asn Lys 
225                 230                 235                 240 


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
                245                 250                 255     


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
            260                 265                 270         


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
        275                 280                 285             


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu 
    290                 295                 300                 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
305                 310                 315                 320 


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
                325                 330                 335     


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
            340                 345                 350         


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
        355                 360                 365             


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
    370                 375                 380                 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
385                 390                 395                 400 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
                405                 410                 415     


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
            420                 425                 430         


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
        435                 440                 445             


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
    450                 455                 460                 


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
465                 470                 475                 480 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
                485                 490                 495     


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
            500                 505                 510         


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
        515                 520                 525             


His Gly Met Asp Glu Leu Tyr Lys 
    530                 535     


<210>  2
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu 
        275                 280                 285             


Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala 
    290                 295                 300                 


Val Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly 
305                 310                 315                 320 


Ala Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val 
                325                 330                 335     


Phe Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu 
            340                 345                 350         


Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met 
        355                 360                 365             


Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys 
    370                 375                 380                 


Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr 
385                 390                 395                 400 


Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp 
                405                 410                 415     


Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro 
            420                 425                 430         


Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr 
        435                 440                 445             


Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly 
    450                 455                 460                 


Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val 
465                 470                 475                 480 


Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val 
                485                 490                 495     


Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
            500                 505                 510         


Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser 
        515                 520                 525             


Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln 
    530                 535                 540                 


Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys 
545                 550                 555                 560 


Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly 
                565                 570                 575     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            580                 585                 590         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        595                 600                 605             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    610                 615                 620                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
625                 630                 635                 640 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                645                 650                 655     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            660                 665                 670         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        675                 680                 685             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    690                 695                 700                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
705                 710                 715                 720 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                725                 730                 735     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            740                 745                 750         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        755                 760                 765             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    770                 775                 780                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
785                 790                 795                 800 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 810 


<210>  3
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ala 
                325                 330                 335     


Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu Leu 
            340                 345                 350         


Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val Gly 
        355                 360                 365             


Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly 
    370                 375                 380                 


Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu 
385                 390                 395                 400 


Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu 
                405                 410                 415     


Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val 
            420                 425                 430         


Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu 
        435                 440                 445             


Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn 
    450                 455                 460                 


His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys 
465                 470                 475                 480 


Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys 
                485                 490                 495     


Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly 
            500                 505                 510         


Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys 
        515                 520                 525             


Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala 
    530                 535                 540                 


Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys 
545                 550                 555                 560 


Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Met Ser Lys Gly 
                565                 570                 575     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            580                 585                 590         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        595                 600                 605             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    610                 615                 620                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
625                 630                 635                 640 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                645                 650                 655     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            660                 665                 670         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        675                 680                 685             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    690                 695                 700                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
705                 710                 715                 720 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                725                 730                 735     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            740                 745                 750         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        755                 760                 765             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    770                 775                 780                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
785                 790                 795                 800 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 810 


<210>  4
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Asn Arg 
225                 230                 235                 240 


Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser 
                245                 250                 255     


Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe 
            260                 265                 270         


Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro 
        275                 280                 285             


Gln Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    290                 295                 300                 


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
305                 310                 315                 320 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                325                 330                 335     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            340                 345                 350         


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        355                 360                 365             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    370                 375                 380                 


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
385                 390                 395                 400 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                405                 410                 415     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
            420                 425                 430         


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
        435                 440                 445             


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
    450                 455                 460                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
465                 470                 475                 480 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
                485                 490                 495     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
            500                 505                 510         


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        515                 520                 525         


<210>  5
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu 
        275                 280                 285             


Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala 
    290                 295                 300                 


Val Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly 
305                 310                 315                 320 


Ala Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val 
                325                 330                 335     


Phe Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu 
            340                 345                 350         


Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met 
        355                 360                 365             


Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys 
    370                 375                 380                 


Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr 
385                 390                 395                 400 


Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp 
                405                 410                 415     


Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro 
            420                 425                 430         


Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr 
        435                 440                 445             


Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly 
    450                 455                 460                 


Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val 
465                 470                 475                 480 


Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val 
                485                 490                 495     


Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
            500                 505                 510         


Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn 
        515                 520                 525             


Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe 
    530                 535                 540                 


Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile 
545                 550                 555                 560 


Lys Pro Gln Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
                565                 570                 575     


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
            580                 585                 590         


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        595                 600                 605             


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    610                 615                 620                 


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
625                 630                 635                 640 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                645                 650                 655     


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            660                 665                 670         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        675                 680                 685             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
    690                 695                 700                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
705                 710                 715                 720 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
                725                 730                 735     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            740                 745                 750         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
        755                 760                 765             


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu 
    770                 775                 780                 


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
785                 790                 795                 800 


Lys 
    


<210>  6
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Ala Val Glu Gly Gly Met Lys Cys Val Lys 
                325                 330                 335     


Phe Leu Leu Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly 
            340                 345                 350         


Leu Ile Ala Val Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile 
        355                 360                 365             


Ile Gln Gly Ala Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala 
    370                 375                 380                 


Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala 
385                 390                 395                 400 


Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser 
                405                 410                 415     


Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe 
            420                 425                 430         


Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met 
        435                 440                 445             


Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met 
    450                 455                 460                 


Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu 
465                 470                 475                 480 


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
                485                 490                 495     


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
            500                 505                 510         


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
        515                 520                 525             


Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu 
    530                 535                 540                 


Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr 
545                 550                 555                 560 


Glu Val Met Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
                565                 570                 575     


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
            580                 585                 590         


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        595                 600                 605             


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    610                 615                 620                 


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
625                 630                 635                 640 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                645                 650                 655     


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            660                 665                 670         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        675                 680                 685             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
    690                 695                 700                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
705                 710                 715                 720 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
                725                 730                 735     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            740                 745                 750         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
        755                 760                 765             


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu 
    770                 775                 780                 


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
785                 790                 795                 800 


Lys 
    


<210>  7
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Asn Arg 
225                 230                 235                 240 


Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly 
                245                 250                 255     


Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val 
            260                 265                 270         


Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu 
        275                 280                 285             


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
    290                 295                 300                 


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
305                 310                 315                 320 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
                325                 330                 335     


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
            340                 345                 350         


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
        355                 360                 365             


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
    370                 375                 380                 


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
385                 390                 395                 400 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
                405                 410                 415     


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
            420                 425                 430         


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
        435                 440                 445             


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
    450                 455                 460                 


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
465                 470                 475                 480 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
                485                 490                 495     


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
            500                 505                 510         


Thr His Gly Met Asp Glu Leu Tyr Lys 
        515                 520     


<210>  8
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr 
        275                 280                 285             


Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val 
    290                 295                 300                 


Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala 
305                 310                 315                 320 


Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe 
                325                 330                 335     


Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn 
            340                 345                 350         


Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu 
        355                 360                 365             


Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val 
    370                 375                 380                 


Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro 
385                 390                 395                 400 


Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe 
                405                 410                 415     


Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser 
            420                 425                 430         


Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val 
        435                 440                 445             


Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys 
    450                 455                 460                 


Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala 
465                 470                 475                 480 


Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe 
                485                 490                 495     


Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Asn 
            500                 505                 510         


Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp 
        515                 520                 525             


Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro 
    530                 535                 540                 


Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly 
545                 550                 555                 560 


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
                565                 570                 575     


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
            580                 585                 590         


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
        595                 600                 605             


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
    610                 615                 620                 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
625                 630                 635                 640 


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
                645                 650                 655     


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
            660                 665                 670         


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
        675                 680                 685             


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
    690                 695                 700                 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
705                 710                 715                 720 


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
                725                 730                 735     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            740                 745                 750         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        755                 760                 765             


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
    770                 775                 780                 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 


<210>  9
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ala 
305                 310                 315                 320 


Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu Leu 
                325                 330                 335     


Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val Gly 
            340                 345                 350         


Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly 
        355                 360                 365             


Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu 
    370                 375                 380                 


Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu 
385                 390                 395                 400 


Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val 
                405                 410                 415     


Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu 
            420                 425                 430         


Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn 
        435                 440                 445             


His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys 
    450                 455                 460                 


Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys 
465                 470                 475                 480 


Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly 
                485                 490                 495     


Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys 
            500                 505                 510         


Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala 
        515                 520                 525             


Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys 
    530                 535                 540                 


Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Met Ser Lys Gly 
545                 550                 555                 560 


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
                565                 570                 575     


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
            580                 585                 590         


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
        595                 600                 605             


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
    610                 615                 620                 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
625                 630                 635                 640 


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
                645                 650                 655     


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
            660                 665                 670         


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
        675                 680                 685             


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
    690                 695                 700                 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
705                 710                 715                 720 


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
                725                 730                 735     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            740                 745                 750         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        755                 760                 765             


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
    770                 775                 780                 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 


<210>  10
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly 
                245                 250                 255     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            260                 265                 270         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        275                 280                 285             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    290                 295                 300                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
305                 310                 315                 320 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                325                 330                 335     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            340                 345                 350         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        355                 360                 365             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    370                 375                 380                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
385                 390                 395                 400 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                405                 410                 415     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            420                 425                 430         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        435                 440                 445             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    450                 455                 460                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
465                 470                 475                 480 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                485                 490 


<210>  11
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ala Val 
        275                 280                 285             


Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val Gly Ala 
305                 310                 315                 320 


Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly Ser 
                325                 330                 335     


Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val 
            340                 345                 350         


Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met 
        355                 360                 365             


Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala 
    370                 375                 380                 


Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe 
385                 390                 395                 400 


Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His 
                405                 410                 415     


Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly 
            420                 425                 430         


Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn 
        435                 440                 445             


Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile 
    450                 455                 460                 


Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile 
465                 470                 475                 480 


Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu 
                485                 490                 495     


Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu 
            500                 505                 510         


Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Met Ser Lys Gly Glu 
        515                 520                 525             


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
    530                 535                 540                 


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
545                 550                 555                 560 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
                565                 570                 575     


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
            580                 585                 590         


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
        595                 600                 605             


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
    610                 615                 620                 


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
625                 630                 635                 640 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
                645                 650                 655     


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
            660                 665                 670         


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
        675                 680                 685             


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
    690                 695                 700                 


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
705                 710                 715                 720 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
                725                 730                 735     


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
            740                 745                 750         


Thr His Gly Met Asp Glu Leu Tyr Lys 
        755                 760     


<210>  12
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met 
                245                 250                 255     


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            260                 265                 270         


Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr 
        275                 280                 285             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
    290                 295                 300                 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln 
            340                 345                 350         


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
    370                 375                 380                 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
385                 390                 395                 400 


Gly Tyr Ser Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr 
            420                 425                 430         


Thr Asn Tyr Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
        435                 440                 445             


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
    450                 455                 460                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met 
465                 470                 475                 480 


Asp Thr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490                 495     


Ala Ser Thr Lys 
            500 


<210>  13
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly 
                245                 250                 255     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            260                 265                 270         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        275                 280                 285             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    290                 295                 300                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
305                 310                 315                 320 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                325                 330                 335     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            340                 345                 350         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        355                 360                 365             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    370                 375                 380                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
385                 390                 395                 400 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                405                 410                 415     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            420                 425                 430         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        435                 440                 445             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    450                 455                 460                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
465                 470                 475                 480 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln 
                485                 490                 495     


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
            500                 505                 510         


Cys Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln 
        515                 520                 525             


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
    530                 535                 540                 


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
545                 550                 555                 560 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
                565                 570                 575     


Tyr Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr 
            580                 585                 590         


Lys Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
    610                 615                 620                 


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
625                 630                 635                 640 


Ser Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys 
                645                 650                 655     


Gly Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn 
            660                 665                 670         


Tyr Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
        675                 680                 685             


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
    690                 695                 700                 


Ala Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr 
705                 710                 715                 720 


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                725                 730                 735     


Thr Lys 
        


<210>  14
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Ala Val Glu Gly Gly Met Lys Cys Val Lys 
    530                 535                 540                 


Phe Leu Leu Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly 
545                 550                 555                 560 


Leu Ile Ala Val Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile 
                565                 570                 575     


Ile Gln Gly Ala Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala 
            580                 585                 590         


Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala 
        595                 600                 605             


Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser 
    610                 615                 620                 


Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe 
625                 630                 635                 640 


Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met 
                645                 650                 655     


Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met 
            660                 665                 670         


Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu 
        675                 680                 685             


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
    690                 695                 700                 


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
705                 710                 715                 720 


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
                725                 730                 735     


Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu 
            740                 745                 750         


Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr 
        755                 760                 765             


Glu Val Met Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
    770                 775                 780                 


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
785                 790                 795                 800 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
                805                 810                 815     


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
            820                 825                 830         


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
        835                 840                 845             


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
    850                 855                 860                 


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
865                 870                 875                 880 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
                885                 890                 895     


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
            900                 905                 910         


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
        915                 920                 925             


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
    930                 935                 940                 


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
945                 950                 955                 960 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
                965                 970                 975     


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu 
            980                 985                 990         


Glu Phe Val Thr Ala Ala Gly Ile  Thr His Gly Met Asp  Glu Leu Tyr 
        995                 1000                 1005             


Lys 
    


<210>  15
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ala Val 
        275                 280                 285             


Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val Gly Ala 
305                 310                 315                 320 


Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly Ser 
                325                 330                 335     


Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val 
            340                 345                 350         


Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met 
        355                 360                 365             


Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala 
    370                 375                 380                 


Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe 
385                 390                 395                 400 


Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His 
                405                 410                 415     


Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly 
            420                 425                 430         


Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn 
        435                 440                 445             


Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile 
    450                 455                 460                 


Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile 
465                 470                 475                 480 


Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu 
                485                 490                 495     


Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu 
            500                 505                 510         


Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
        515                 520             


<210>  16
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu 
                245                 250                 255     


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
            260                 265                 270         


Ser Cys Ser Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln 
        275                 280                 285             


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu 
    290                 295                 300                 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
305                 310                 315                 320 


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp 
                325                 330                 335     


Tyr Tyr Cys Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
    370                 375                 380                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
385                 390                 395                 400 


Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile 
                405                 410                 415     


Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys 
            420                 425                 430         


Arg Ser Lys Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile 
        435                 440                 445             


Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn 
    450                 455                 460                 


Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser 
465                 470                 475                 480 


Tyr Pro Phe Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala Ser Thr Lys 
            500             


<210>  17
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly 
                245                 250                 255     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            260                 265                 270         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        275                 280                 285             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    290                 295                 300                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
305                 310                 315                 320 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                325                 330                 335     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            340                 345                 350         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        355                 360                 365             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    370                 375                 380                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
385                 390                 395                 400 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                405                 410                 415     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            420                 425                 430         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        435                 440                 445             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    450                 455                 460                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
465                 470                 475                 480 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln 
                485                 490                 495     


Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys 
            500                 505                 510         


Ser Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys 
        515                 520                 525             


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro 
    530                 535                 540                 


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
545                 550                 555                 560 


Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
                565                 570                 575     


Cys Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr 
            580                 585                 590         


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly 
        595                 600                 605             


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
    610                 615                 620                 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
625                 630                 635                 640 


Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln 
                645                 650                 655     


Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser 
            660                 665                 670         


Lys Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile 
        675                 680                 685             


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
    690                 695                 700                 


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro 
705                 710                 715                 720 


Phe Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                725                 730                 735     


Ser Ala Ser Thr Lys 
            740     


<210>  18
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Ala Val Glu Gly Gly Met Lys 
    530                 535                 540                 


Cys Val Lys Phe Leu Leu Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys 
545                 550                 555                 560 


Ala Val Gly Leu Ile Ala Val Gly Val Gly Ala Gln Leu Val Leu Ser 
                565                 570                 575     


Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly Ser Leu Leu Pro Val Val 
            580                 585                 590         


Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile 
    610                 615                 620                 


Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala Gly 
625                 630                 635                 640 


Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg 
                645                 650                 655     


Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu 
            660                 665                 670         


Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr 
        675                 680                 685             


Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser 
    690                 695                 700                 


Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys 
705                 710                 715                 720 


Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg 
                725                 730                 735     


Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val 
            740                 745                 750         


Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg 
        755                 760                 765             


Ser Gly Tyr Glu Val Met Met Ser Lys Gly Glu Glu Leu Phe Thr Gly 
    770                 775                 780                 


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys 
785                 790                 795                 800 


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
                805                 810                 815     


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
            820                 825                 830         


Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
        835                 840                 845             


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
    850                 855                 860                 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr 
865                 870                 875                 880 


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
                885                 890                 895     


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
            900                 905                 910         


His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
        915                 920                 925             


Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
    930                 935                 940                 


Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
945                 950                 955                 960 


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
                965                 970                 975     


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
            980                 985                 990         


Ile Leu Leu Glu Phe Val Thr Ala  Ala Gly Ile Thr His  Gly Met Asp 
        995                 1000                 1005             


Glu Leu  Tyr Lys 
    1010         


<210>  19
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
    290                 295                 300                 


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
305                 310                 315                 320 


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
                325                 330                 335     


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
            340                 345                 350         


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
        355                 360                 365             


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
    370                 375                 380                 


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
385                 390                 395                 400 


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
                405                 410                 415     


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
            420                 425                 430         


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
        435                 440                 445             


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
    450                 455                 460                 


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
465                 470                 475                 480 


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
                485                 490                 495     


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
            500                 505                 510         


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
        515                 520                 525     


<210>  20
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met 
                245                 250                 255     


Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr 
            260                 265                 270         


Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr 
        275                 280                 285             


Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys 
    290                 295                 300                 


Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly 
305                 310                 315                 320 


Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly 
                325                 330                 335     


Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser 
            340                 345                 350         


Gly Thr Lys Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro 
    370                 375                 380                 


Gly Ala Glu Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys 
385                 390                 395                 400 


Ala Ser Gly Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln 
                405                 410                 415     


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn 
            420                 425                 430         


Gly Arg Ile Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
    450                 455                 460                 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile 
465                 470                 475                 480 


Thr Thr Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                485                 490                 495     


Ala Ser Thr Lys 
            500 


<210>  21
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Phe 
225                 230                 235                 240 


Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly 
                245                 250                 255     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            260                 265                 270         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        275                 280                 285             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    290                 295                 300                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
305                 310                 315                 320 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                325                 330                 335     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            340                 345                 350         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        355                 360                 365             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    370                 375                 380                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
385                 390                 395                 400 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                405                 410                 415     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            420                 425                 430         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        435                 440                 445             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    450                 455                 460                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
465                 470                 475                 480 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln 
                485                 490                 495     


Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr 
            500                 505                 510         


Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln 
        515                 520                 525             


Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu 
    530                 535                 540                 


Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln 
545                 550                 555                 560 


Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr 
                565                 570                 575     


Tyr Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr 
            580                 585                 590         


Lys Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly 
        595                 600                 605             


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
    610                 615                 620                 


Glu Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser 
625                 630                 635                 640 


Gly Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro 
                645                 650                 655     


Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg 
            660                 665                 670         


Ile Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
    690                 695                 700                 


Asp Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr 
705                 710                 715                 720 


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser 
                725                 730                 735     


Thr Lys 
        


<210>  22
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Ala Val Glu Gly Gly Met Lys Cys Val Lys 
    530                 535                 540                 


Phe Leu Leu Tyr Val Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly 
545                 550                 555                 560 


Leu Ile Ala Val Gly Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile 
                565                 570                 575     


Ile Gln Gly Ala Thr Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala 
            580                 585                 590         


Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala 
        595                 600                 605             


Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser 
    610                 615                 620                 


Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe 
625                 630                 635                 640 


Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met 
                645                 650                 655     


Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met 
            660                 665                 670         


Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu 
        675                 680                 685             


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
    690                 695                 700                 


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
705                 710                 715                 720 


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
                725                 730                 735     


Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu 
            740                 745                 750         


Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr 
        755                 760                 765             


Glu Val Met Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
    770                 775                 780                 


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
785                 790                 795                 800 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
                805                 810                 815     


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
            820                 825                 830         


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
        835                 840                 845             


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
    850                 855                 860                 


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
865                 870                 875                 880 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
                885                 890                 895     


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
            900                 905                 910         


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
        915                 920                 925             


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
    930                 935                 940                 


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
945                 950                 955                 960 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
                965                 970                 975     


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu 
            980                 985                 990         


Glu Phe Val Thr Ala Ala Gly Ile  Thr His Gly Met Asp  Glu Leu Tyr 
        995                 1000                 1005             


Lys 
    


<210>  23
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ala Val 
        275                 280                 285             


Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val Gly Ala 
305                 310                 315                 320 


Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro Gly Ser 
                325                 330                 335     


Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val 
            340                 345                 350         


Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met 
        355                 360                 365             


Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala 
    370                 375                 380                 


Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe 
385                 390                 395                 400 


Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His 
                405                 410                 415     


Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly 
            420                 425                 430         


Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn 
        435                 440                 445             


Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile 
    450                 455                 460                 


Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile 
465                 470                 475                 480 


Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu 
                485                 490                 495     


Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu 
            500                 505                 510         


Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
        515                 520             


<210>  24
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val 
225                 230                 235                 240 


Gly Phe Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln 
                245                 250                 255     


Val Leu Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser 
            260                 265                 270         


Cys Arg Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser 
        275                 280                 285             


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
    290                 295                 300                 


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
305                 310                 315                 320 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
                325                 330                 335     


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
            340                 345                 350         


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
        355                 360                 365             


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
    370                 375                 380                 


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
385                 390                 395                 400 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
                405                 410                 415     


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
            420                 425                 430         


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
        435                 440                 445             


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
    450                 455                 460                 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
465                 470                 475                 480 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
                485                 490                 495     


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
            500                 505                 510         


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        515                 520                 525     


<210>  25
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu 
        275                 280                 285             


Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala 
    290                 295                 300                 


Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu 
305                 310                 315                 320 


Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile 
                325                 330                 335     


Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys 
            340                 345                 350         


Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly 
        355                 360                 365             


Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly 
    370                 375                 380                 


Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys 
385                 390                 395                 400 


Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr 
                405                 410                 415     


Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly 
            420                 425                 430         


Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu 
        435                 440                 445             


Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp 
    450                 455                 460                 


Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val 
465                 470                 475                 480 


Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg 
                485                 490                 495     


Arg Asn Arg Glu Met Val Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser 
            500                 505                 510         


Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu 
        515                 520                 525             


Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala 
    530                 535                 540                 


Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn 
545                 550                 555                 560 


Glu Ser Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                565                 570                 575     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            580                 585                 590         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        595                 600                 605             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    610                 615                 620                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
625                 630                 635                 640 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                645                 650                 655     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            660                 665                 670         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        675                 680                 685             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    690                 695                 700                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
705                 710                 715                 720 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                725                 730                 735     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            740                 745                 750         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        755                 760                 765             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    770                 775                 780                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 795                 800 


<210>  26
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Pro 
                325                 330                 335     


Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn 
            340                 345                 350         


Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu Trp 
        355                 360                 365             


Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn 
    370                 375                 380                 


Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
385                 390                 395                 400 


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
                405                 410                 415     


Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val 
            420                 425                 430         


Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys 
        435                 440                 445             


Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn 
    450                 455                 460                 


Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile 
465                 470                 475                 480 


His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe 
                485                 490                 495     


Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val 
            500                 505                 510         


Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His 
        515                 520                 525             


Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly 
    530                 535                 540                 


Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu 
545                 550                 555                 560 


Met Val Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                565                 570                 575     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            580                 585                 590         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        595                 600                 605             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    610                 615                 620                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
625                 630                 635                 640 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                645                 650                 655     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            660                 665                 670         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        675                 680                 685             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    690                 695                 700                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
705                 710                 715                 720 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                725                 730                 735     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            740                 745                 750         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        755                 760                 765             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    770                 775                 780                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 795                 800 


<210>  27
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln 
225                 230                 235                 240 


Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg 
                245                 250                 255     


Ser Thr Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr 
            260                 265                 270         


Arg Pro Leu Ile Lys Pro Gln Met Ser Lys Gly Glu Glu Leu Phe Thr 
        275                 280                 285             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
    290                 295                 300                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
305                 310                 315                 320 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                325                 330                 335     


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
            340                 345                 350         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        355                 360                 365             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
    370                 375                 380                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
385                 390                 395                 400 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                405                 410                 415     


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
            420                 425                 430         


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
        435                 440                 445             


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    450                 455                 460                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
465                 470                 475                 480 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                485                 490                 495     


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
            500                 505                 510         


Asp Glu Leu Tyr Lys 
        515         


<210>  28
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu 
        275                 280                 285             


Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala 
    290                 295                 300                 


Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu 
305                 310                 315                 320 


Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile 
                325                 330                 335     


Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys 
            340                 345                 350         


Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly 
        355                 360                 365             


Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly 
    370                 375                 380                 


Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys 
385                 390                 395                 400 


Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr 
                405                 410                 415     


Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly 
            420                 425                 430         


Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu 
        435                 440                 445             


Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp 
    450                 455                 460                 


Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val 
465                 470                 475                 480 


Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg 
                485                 490                 495     


Arg Asn Arg Glu Met Val Asn Arg Ile Ser Pro Leu Val Lys Asp Thr 
            500                 505                 510         


Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys 
        515                 520                 525             


Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His 
    530                 535                 540                 


Phe Thr Arg Pro Leu Ile Lys Pro Gln Met Ser Lys Gly Glu Glu Leu 
545                 550                 555                 560 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                565                 570                 575     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            580                 585                 590         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        595                 600                 605             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    610                 615                 620                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
625                 630                 635                 640 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                645                 650                 655     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            660                 665                 670         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        675                 680                 685             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    690                 695                 700                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
705                 710                 715                 720 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                725                 730                 735     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            740                 745                 750         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        755                 760                 765             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    770                 775                 780                 


Gly Met Asp Glu Leu Tyr Lys 
785                 790     


<210>  29
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys 
                325                 330                 335     


Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala 
            340                 345                 350         


Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser 
        355                 360                 365             


Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
    370                 375                 380                 


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
385                 390                 395                 400 


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
                405                 410                 415     


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
            420                 425                 430         


Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu 
        435                 440                 445             


Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln 
    450                 455                 460                 


Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu 
465                 470                 475                 480 


Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp 
                485                 490                 495     


Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu 
            500                 505                 510         


Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile 
        515                 520                 525             


Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys 
    530                 535                 540                 


Ala Ile Arg Arg Asn Arg Glu Met Val Met Ser Lys Gly Glu Glu Leu 
545                 550                 555                 560 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                565                 570                 575     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            580                 585                 590         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        595                 600                 605             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    610                 615                 620                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
625                 630                 635                 640 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                645                 650                 655     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            660                 665                 670         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        675                 680                 685             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    690                 695                 700                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
705                 710                 715                 720 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                725                 730                 735     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            740                 745                 750         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        755                 760                 765             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    770                 775                 780                 


Gly Met Asp Glu Leu Tyr Lys 
785                 790     


<210>  30
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr 
225                 230                 235                 240 


Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp 
                245                 250                 255     


Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro 
            260                 265                 270         


Asn Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
        275                 280                 285             


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
    290                 295                 300                 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
305                 310                 315                 320 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
                325                 330                 335     


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
            340                 345                 350         


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
        355                 360                 365             


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
    370                 375                 380                 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
385                 390                 395                 400 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
                405                 410                 415     


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
            420                 425                 430         


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
        435                 440                 445             


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
    450                 455                 460                 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
465                 470                 475                 480 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
                485                 490                 495     


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            500                 505                 510     


<210>  31
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe 
        275                 280                 285             


Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile 
    290                 295                 300                 


Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln 
305                 310                 315                 320 


Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu 
                325                 330                 335     


Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys 
            340                 345                 350         


Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe 
        355                 360                 365             


Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr 
    370                 375                 380                 


Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp 
385                 390                 395                 400 


Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu 
                405                 410                 415     


Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val 
            420                 425                 430         


Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr 
        435                 440                 445             


Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn 
    450                 455                 460                 


Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met 
465                 470                 475                 480 


Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg 
                485                 490                 495     


Asn Arg Glu Met Val Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala 
            500                 505                 510         


Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly 
        515                 520                 525             


Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg 
    530                 535                 540                 


Pro Asn Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
545                 550                 555                 560 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
                565                 570                 575     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
            580                 585                 590         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        595                 600                 605             


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
    610                 615                 620                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
625                 630                 635                 640 


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                645                 650                 655     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            660                 665                 670         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
        675                 680                 685             


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
    690                 695                 700                 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
705                 710                 715                 720 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                725                 730                 735     


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
            740                 745                 750         


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
        755                 760                 765             


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    770                 775                 780                 


<210>  32
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Pro 
305                 310                 315                 320 


Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn 
                325                 330                 335     


Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu Trp 
            340                 345                 350         


Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn 
        355                 360                 365             


Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
    370                 375                 380                 


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
385                 390                 395                 400 


Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val 
                405                 410                 415     


Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys 
            420                 425                 430         


Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn 
        435                 440                 445             


Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile 
    450                 455                 460                 


His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe 
465                 470                 475                 480 


Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val 
                485                 490                 495     


Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His 
            500                 505                 510         


Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly 
        515                 520                 525             


Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu 
    530                 535                 540                 


Met Val Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
545                 550                 555                 560 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
                565                 570                 575     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
            580                 585                 590         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        595                 600                 605             


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
    610                 615                 620                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
625                 630                 635                 640 


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                645                 650                 655     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            660                 665                 670         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
        675                 680                 685             


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
    690                 695                 700                 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
705                 710                 715                 720 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                725                 730                 735     


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
            740                 745                 750         


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
        755                 760                 765             


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    770                 775                 780                 


<210>  33
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                245                 250                 255     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            260                 265                 270         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        275                 280                 285             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    290                 295                 300                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
305                 310                 315                 320 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                325                 330                 335     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            340                 345                 350         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        355                 360                 365             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    370                 375                 380                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
385                 390                 395                 400 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                405                 410                 415     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            420                 425                 430         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        435                 440                 445             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    450                 455                 460                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475                 480 


<210>  34
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Pro Val 
        275                 280                 285             


Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn Phe 
    290                 295                 300                 


Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu Trp Leu 
305                 310                 315                 320 


Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn Asn 
                325                 330                 335     


Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly 
            340                 345                 350         


Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln 
        355                 360                 365             


Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile 
    370                 375                 380                 


Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys Asp 
385                 390                 395                 400 


Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn Lys 
                405                 410                 415     


Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile His 
            420                 425                 430         


Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile 
        435                 440                 445             


Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys 
    450                 455                 460                 


Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile 
465                 470                 475                 480 


Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met 
                485                 490                 495     


Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met 
            500                 505                 510         


Val Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
        515                 520                 525             


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
    530                 535                 540                 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
545                 550                 555                 560 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
                565                 570                 575     


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
            580                 585                 590         


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
        595                 600                 605             


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
    610                 615                 620                 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
625                 630                 635                 640 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
                645                 650                 655     


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
            660                 665                 670         


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
        675                 680                 685             


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
    690                 695                 700                 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
705                 710                 715                 720 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
                725                 730                 735     


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            740                 745                 750     


<210>  35
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                245                 250                 255     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            260                 265                 270         


Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        275                 280                 285             


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
305                 310                 315                 320 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
                325                 330                 335     


Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            340                 345                 350         


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln 
        355                 360                 365             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
    370                 375                 380                 


Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr Trp Val Gly 
385                 390                 395                 400 


Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Phe Ile 
                405                 410                 415     


Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro Ser Phe Gln Gly Gln 
            420                 425                 430         


Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp 
        435                 440                 445             


Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu 
    450                 455                 460                 


Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
                485                 490 


<210>  36
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                245                 250                 255     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            260                 265                 270         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        275                 280                 285             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    290                 295                 300                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
305                 310                 315                 320 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                325                 330                 335     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            340                 345                 350         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        355                 360                 365             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    370                 375                 380                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
385                 390                 395                 400 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                405                 410                 415     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            420                 425                 430         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        435                 440                 445             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    450                 455                 460                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475                 480 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                485                 490                 495     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Leu Tyr 
            500                 505                 510         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        515                 520                 525             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    530                 535                 540                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
545                 550                 555                 560 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Ser Tyr 
                565                 570                 575     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Gly 
            580                 585                 590         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val 
        595                 600                 605             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
    610                 615                 620                 


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr Trp Val Gly Trp Val 
625                 630                 635                 640 


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Phe Ile Asp Pro 
                645                 650                 655     


Ser Asp Ser Tyr Thr Asn Tyr Ala Pro Ser Phe Gln Gly Gln Val Thr 
            660                 665                 670         


Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser 
        675                 680                 685             


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Leu Tyr 
    690                 695                 700                 


Gln Gly Tyr Met Asp Thr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
705                 710                 715                 720 


Thr Val Ser Ser Ala Ser Thr Lys 
                725             


<210>  37
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys 
    530                 535                 540                 


Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala 
545                 550                 555                 560 


Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser 
                565                 570                 575     


Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
            580                 585                 590         


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
        595                 600                 605             


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
    610                 615                 620                 


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
625                 630                 635                 640 


Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu 
                645                 650                 655     


Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln 
            660                 665                 670         


Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu 
        675                 680                 685             


Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp 
    690                 695                 700                 


Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu 
705                 710                 715                 720 


Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile 
                725                 730                 735     


Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys 
            740                 745                 750         


Ala Ile Arg Arg Asn Arg Glu Met Val Met Ser Lys Gly Glu Glu Leu 
        755                 760                 765             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    770                 775                 780                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
785                 790                 795                 800 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                805                 810                 815     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            820                 825                 830         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        835                 840                 845             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    850                 855                 860                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
865                 870                 875                 880 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                885                 890                 895     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            900                 905                 910         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        915                 920                 925             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    930                 935                 940                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
945                 950                 955                 960 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                965                 970                 975     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            980                 985                 990         


Gly Met Asp Glu Leu Tyr Lys 
        995                 


<210>  38
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Pro Val 
        275                 280                 285             


Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn Phe 
    290                 295                 300                 


Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu Trp Leu 
305                 310                 315                 320 


Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn Asn 
                325                 330                 335     


Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly 
            340                 345                 350         


Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln 
        355                 360                 365             


Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile 
    370                 375                 380                 


Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys Asp 
385                 390                 395                 400 


Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn Lys 
                405                 410                 415     


Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile His 
            420                 425                 430         


Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile 
        435                 440                 445             


Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys 
    450                 455                 460                 


Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile 
465                 470                 475                 480 


Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met 
                485                 490                 495     


Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met 
            500                 505                 510         


Val 
    


<210>  39
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
                245                 250                 255     


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Tyr 
            260                 265                 270         


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
        275                 280                 285             


Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
    290                 295                 300                 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
305                 310                 315                 320 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Asp Pro Asn 
                325                 330                 335     


Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            340                 345                 350         


Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln 
        355                 360                 365             


Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
    370                 375                 380                 


Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser 
385                 390                 395                 400 


Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp 
                405                 410                 415     


Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr Asn Asn Tyr Ala Val 
            420                 425                 430         


Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln 
        435                 440                 445             


Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser Ile Asp Tyr Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
                485                 490             


<210>  40
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                245                 250                 255     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            260                 265                 270         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        275                 280                 285             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    290                 295                 300                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
305                 310                 315                 320 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                325                 330                 335     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            340                 345                 350         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        355                 360                 365             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    370                 375                 380                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
385                 390                 395                 400 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                405                 410                 415     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            420                 425                 430         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        435                 440                 445             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    450                 455                 460                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475                 480 


Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
                485                 490                 495     


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Tyr Tyr Val 
            500                 505                 510         


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        515                 520                 525             


Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    530                 535                 540                 


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
545                 550                 555                 560 


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Asp Pro Asn Phe Gln 
                565                 570                 575     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            580                 585                 590         


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln 
        595                 600                 605             


Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
    610                 615                 620                 


Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
625                 630                 635                 640 


Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly 
                645                 650                 655     


Ile Ile Gln Lys Arg Ser Lys Trp Tyr Asn Asn Tyr Ala Val Ser Val 
            660                 665                 670         


Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
        675                 680                 685             


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser Ile Asp Tyr Trp Gly Gln Gly 
705                 710                 715                 720 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
                725                 730     


<210>  41
<211>  1002
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Pro Val Lys Gly Gly Thr Lys 
    530                 535                 540                 


Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala 
545                 550                 555                 560 


Gly Ile Ala Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln 
                565                 570                 575     


Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe 
            580                 585                 590         


Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu 
        595                 600                 605             


Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met 
    610                 615                 620                 


Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile 
625                 630                 635                 640 


Ala Ala Ala Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu 
                645                 650                 655     


Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp 
            660                 665                 670         


Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys 
        675                 680                 685             


Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro 
    690                 695                 700                 


Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala 
705                 710                 715                 720 


Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly 
                725                 730                 735     


Ile Gly Ile Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile 
            740                 745                 750         


Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met Val Met Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr His Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


<210>  42
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
    290                 295                 300                 


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
305                 310                 315                 320 


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
                325                 330                 335     


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
            340                 345                 350         


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
        355                 360                 365             


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
    370                 375                 380                 


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
385                 390                 395                 400 


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
                405                 410                 415     


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
            420                 425                 430         


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
        435                 440                 445             


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
    450                 455                 460                 


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
465                 470                 475                 480 


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
                485                 490                 495     


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
            500                 505                 510         


Arg Glu Met Val 
        515     


<210>  43
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser 
                245                 250                 255     


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His 
            260                 265                 270         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
        275                 280                 285             


Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe 
    290                 295                 300                 


Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu 
305                 310                 315                 320 


Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr 
                325                 330                 335     


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Gly Thr 
            340                 345                 350         


Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln 
        355                 360                 365             


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Thr Ser 
    370                 375                 380                 


Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr Trp 
385                 390                 395                 400 


Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                405                 410                 415     


Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr Asn Glu Lys Phe Lys 
            420                 425                 430         


Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        435                 440                 445             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
    450                 455                 460                 


Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
                485                 490 


<210>  44
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                245                 250                 255     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
            260                 265                 270         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        275                 280                 285             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    290                 295                 300                 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
305                 310                 315                 320 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                325                 330                 335     


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            340                 345                 350         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        355                 360                 365             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
    370                 375                 380                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
385                 390                 395                 400 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
                405                 410                 415     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            420                 425                 430         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        435                 440                 445             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
    450                 455                 460                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475                 480 


Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
                485                 490                 495     


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            500                 505                 510         


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        515                 520                 525             


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    530                 535                 540                 


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
545                 550                 555                 560 


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe 
                565                 570                 575     


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Gly Thr Val Ala 
            580                 585                 590         


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln 
        595                 600                 605             


Leu Gln Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Thr Ser Val Arg 
    610                 615                 620                 


Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr Trp Ile His 
625                 630                 635                 640 


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile 
                645                 650                 655     


Asn Pro Asn Asn Gly Arg Ile Asn Tyr Asn Glu Lys Phe Lys Thr Lys 
            660                 665                 670         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        675                 680                 685             


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Val 
    690                 695                 700                 


Gly Val Met Ile Thr Thr Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
705                 710                 715                 720 


Thr Val Ser Ala Ala Ser Thr Lys 
                725             


<210>  45
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys 
    530                 535                 540                 


Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala 
545                 550                 555                 560 


Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser 
                565                 570                 575     


Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
            580                 585                 590         


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
        595                 600                 605             


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
    610                 615                 620                 


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
625                 630                 635                 640 


Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu 
                645                 650                 655     


Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln 
            660                 665                 670         


Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu 
        675                 680                 685             


Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp 
    690                 695                 700                 


Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu 
705                 710                 715                 720 


Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile 
                725                 730                 735     


Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys 
            740                 745                 750         


Ala Ile Arg Arg Asn Arg Glu Met Val Met Ser Lys Gly Glu Glu Leu 
        755                 760                 765             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    770                 775                 780                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
785                 790                 795                 800 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                805                 810                 815     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            820                 825                 830         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        835                 840                 845             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    850                 855                 860                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
865                 870                 875                 880 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                885                 890                 895     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            900                 905                 910         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        915                 920                 925             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    930                 935                 940                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
945                 950                 955                 960 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                965                 970                 975     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            980                 985                 990         


Gly Met Asp Glu Leu Tyr Lys 
        995                 


<210>  46
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Pro Val 
        275                 280                 285             


Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe Asn Phe 
    290                 295                 300                 


Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu Trp Leu 
305                 310                 315                 320 


Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr Asn Asn 
                325                 330                 335     


Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly 
            340                 345                 350         


Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln 
        355                 360                 365             


Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile 
    370                 375                 380                 


Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys Asp 
385                 390                 395                 400 


Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn Lys 
                405                 410                 415     


Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile His 
            420                 425                 430         


Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile 
        435                 440                 445             


Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys 
    450                 455                 460                 


Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile 
465                 470                 475                 480 


Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met 
                485                 490                 495     


Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met 
            500                 505                 510         


Val 
    


<210>  47
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Lys Ile Ser 
225                 230                 235                 240 


Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr 
                245                 250                 255     


Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe 
            260                 265                 270         


Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala 
        275                 280                 285             


Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu Phe 
    290                 295                 300                 


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
305                 310                 315                 320 


Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
                325                 330                 335     


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
            340                 345                 350         


Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser 
        355                 360                 365             


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
    370                 375                 380                 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly 
385                 390                 395                 400 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
                405                 410                 415     


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
            420                 425                 430         


Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
        435                 440                 445             


Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
    450                 455                 460                 


His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
465                 470                 475                 480 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
                485                 490                 495     


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
            500                 505                 510         


His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
        515                 520                 525             


Met Asp Glu Leu Tyr Lys 
    530                 


<210>  48
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu 
        275                 280                 285             


Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly 
    290                 295                 300                 


Val Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr 
305                 310                 315                 320 


Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile 
                325                 330                 335     


Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu 
            340                 345                 350         


Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe 
        355                 360                 365             


Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile 
    370                 375                 380                 


Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe 
385                 390                 395                 400 


Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn 
                405                 410                 415     


Ala Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly 
            420                 425                 430         


Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu 
        435                 440                 445             


Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys 
    450                 455                 460                 


His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly 
465                 470                 475                 480 


Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu 
                485                 490                 495     


Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Lys 
            500                 505                 510         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        515                 520                 525             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    530                 535                 540                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
545                 550                 555                 560 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu 
                565                 570                 575     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            580                 585                 590         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        595                 600                 605             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    610                 615                 620                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
625                 630                 635                 640 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                645                 650                 655     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            660                 665                 670         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        675                 680                 685             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    690                 695                 700                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
705                 710                 715                 720 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                725                 730                 735     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            740                 745                 750         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        755                 760                 765             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    770                 775                 780                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
785                 790                 795                 800 


His Gly Met Asp Glu Leu Tyr Lys 
                805             


<210>  49
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Gly 
                325                 330                 335     


Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn 
            340                 345                 350         


Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp 
        355                 360                 365             


Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly 
    370                 375                 380                 


Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile 
385                 390                 395                 400 


Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly 
                405                 410                 415     


Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu 
            420                 425                 430         


Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val 
        435                 440                 445             


Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala 
    450                 455                 460                 


Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val 
465                 470                 475                 480 


Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu 
                485                 490                 495     


Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly 
            500                 505                 510         


Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile 
        515                 520                 525             


Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile 
    530                 535                 540                 


Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu 
545                 550                 555                 560 


Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Met Ser Lys Gly Glu Glu 
                565                 570                 575     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            580                 585                 590         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        595                 600                 605             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    610                 615                 620                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
625                 630                 635                 640 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                645                 650                 655     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            660                 665                 670         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        675                 680                 685             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    690                 695                 700                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
705                 710                 715                 720 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                725                 730                 735     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            740                 745                 750         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        755                 760                 765             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    770                 775                 780                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
785                 790                 795                 800 


His Gly Met Asp Glu Leu Tyr Lys 
                805             


<210>  50
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Arg Ile Ser 
225                 230                 235                 240 


Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe 
                245                 250                 255     


Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro 
            260                 265                 270         


His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Met 
        275                 280                 285             


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
    290                 295                 300                 


Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly 
305                 310                 315                 320 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
                325                 330                 335     


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
            340                 345                 350         


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
        355                 360                 365             


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
    370                 375                 380                 


Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
385                 390                 395                 400 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
                405                 410                 415     


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr 
            420                 425                 430         


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile 
        435                 440                 445             


Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln 
    450                 455                 460                 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
465                 470                 475                 480 


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                485                 490                 495     


Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr 
            500                 505                 510         


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        515                 520                 525 


<210>  51
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu 
        275                 280                 285             


Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly 
    290                 295                 300                 


Val Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr 
305                 310                 315                 320 


Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile 
                325                 330                 335     


Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu 
            340                 345                 350         


Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe 
        355                 360                 365             


Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile 
    370                 375                 380                 


Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe 
385                 390                 395                 400 


Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn 
                405                 410                 415     


Ala Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly 
            420                 425                 430         


Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu 
        435                 440                 445             


Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys 
    450                 455                 460                 


His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly 
465                 470                 475                 480 


Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu 
                485                 490                 495     


Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Arg 
            500                 505                 510         


Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser 
        515                 520                 525             


Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe 
    530                 535                 540                 


Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro 
545                 550                 555                 560 


Gln Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                565                 570                 575     


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
            580                 585                 590         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        595                 600                 605             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    610                 615                 620                 


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
625                 630                 635                 640 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                645                 650                 655     


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            660                 665                 670         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        675                 680                 685             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
    690                 695                 700                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
705                 710                 715                 720 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
                725                 730                 735     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            740                 745                 750         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        755                 760                 765             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
    770                 775                 780                 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 795                 


<210>  52
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys 
                325                 330                 335     


Tyr Leu Leu Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val 
            340                 345                 350         


Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn 
        355                 360                 365             


Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr 
    370                 375                 380                 


Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val 
385                 390                 395                 400 


Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu 
                405                 410                 415     


Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala 
            420                 425                 430         


Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val 
        435                 440                 445             


Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp 
    450                 455                 460                 


Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp 
465                 470                 475                 480 


Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys 
                485                 490                 495     


Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys 
            500                 505                 510         


Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr 
        515                 520                 525             


Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu 
    530                 535                 540                 


Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val 
545                 550                 555                 560 


Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                565                 570                 575     


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
            580                 585                 590         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        595                 600                 605             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    610                 615                 620                 


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
625                 630                 635                 640 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                645                 650                 655     


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            660                 665                 670         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        675                 680                 685             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
    690                 695                 700                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
705                 710                 715                 720 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
                725                 730                 735     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            740                 745                 750         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        755                 760                 765             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
    770                 775                 780                 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
785                 790                 795                 


<210>  53
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Arg Ile Ser 
225                 230                 235                 240 


Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu 
                245                 250                 255     


Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr 
            260                 265                 270         


Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu 
        275                 280                 285             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    290                 295                 300                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
305                 310                 315                 320 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                325                 330                 335     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            340                 345                 350         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        355                 360                 365             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    370                 375                 380                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
385                 390                 395                 400 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                405                 410                 415     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            420                 425                 430         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        435                 440                 445             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    450                 455                 460                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
465                 470                 475                 480 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                485                 490                 495     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            500                 505                 510         


Gly Met Asp Glu Leu Tyr Lys 
        515                 


<210>  54
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe 
        275                 280                 285             


Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val 
    290                 295                 300                 


Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr 
                325                 330                 335     


Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly 
            340                 345                 350         


Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe 
        355                 360                 365             


Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp 
    370                 375                 380                 


Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr 
385                 390                 395                 400 


Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala 
                405                 410                 415     


Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser 
            420                 425                 430         


Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys 
        435                 440                 445             


Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His 
    450                 455                 460                 


Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile 
465                 470                 475                 480 


Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser 
                485                 490                 495     


Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Asn Arg Ile 
            500                 505                 510         


Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly 
        515                 520                 525             


Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp 
    530                 535                 540                 


Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu 
545                 550                 555                 560 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                565                 570                 575     


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            580                 585                 590         


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
        595                 600                 605             


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
    610                 615                 620                 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
625                 630                 635                 640 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
                645                 650                 655     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            660                 665                 670         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        675                 680                 685             


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
    690                 695                 700                 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
705                 710                 715                 720 


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
                725                 730                 735     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            740                 745                 750         


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
        755                 760                 765             


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    770                 775                 780                 


His Gly Met Asp Glu Leu Tyr Lys 
785                 790         


<210>  55
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Gly 
305                 310                 315                 320 


Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn 
                325                 330                 335     


Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp 
            340                 345                 350         


Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly 
        355                 360                 365             


Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile 
    370                 375                 380                 


Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly 
385                 390                 395                 400 


Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu 
                405                 410                 415     


Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val 
            420                 425                 430         


Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala 
        435                 440                 445             


Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val 
    450                 455                 460                 


Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu 
465                 470                 475                 480 


Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly 
                485                 490                 495     


Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile 
            500                 505                 510         


Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile 
        515                 520                 525             


Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu 
    530                 535                 540                 


Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Met Ser Lys Gly Glu Glu 
545                 550                 555                 560 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                565                 570                 575     


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            580                 585                 590         


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
        595                 600                 605             


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
    610                 615                 620                 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
625                 630                 635                 640 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
                645                 650                 655     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            660                 665                 670         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        675                 680                 685             


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
    690                 695                 700                 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
705                 710                 715                 720 


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
                725                 730                 735     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            740                 745                 750         


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
        755                 760                 765             


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    770                 775                 780                 


His Gly Met Asp Glu Leu Tyr Lys 
785                 790         


<210>  56
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu 
                245                 250                 255     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            260                 265                 270         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        275                 280                 285             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    290                 295                 300                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
305                 310                 315                 320 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                325                 330                 335     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            340                 345                 350         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        355                 360                 365             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    370                 375                 380                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
385                 390                 395                 400 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                405                 410                 415     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            420                 425                 430         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        435                 440                 445             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    450                 455                 460                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
465                 470                 475                 480 


His Gly Met Asp Glu Leu Tyr Lys 
                485             


<210>  57
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Val 
        275                 280                 285             


Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn Phe 
    290                 295                 300                 


Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu 
305                 310                 315                 320 


Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp 
                325                 330                 335     


Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala 
            340                 345                 350         


Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala 
        355                 360                 365             


Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val 
    370                 375                 380                 


Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn 
385                 390                 395                 400 


Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu 
                405                 410                 415     


Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val 
            420                 425                 430         


Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr 
        435                 440                 445             


Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser 
    450                 455                 460                 


Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp 
465                 470                 475                 480 


Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val 
                485                 490                 495     


Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys 
            500                 505                 510         


Cys Gly Ile Arg Asn Ser Ser Val Tyr Met Ser Lys Gly Glu Glu Leu 
        515                 520                 525             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    530                 535                 540                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
545                 550                 555                 560 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                565                 570                 575     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            580                 585                 590         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        595                 600                 605             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    610                 615                 620                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
625                 630                 635                 640 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                645                 650                 655     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            660                 665                 670         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        675                 680                 685             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    690                 695                 700                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
705                 710                 715                 720 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                725                 730                 735     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            740                 745                 750         


Gly Met Asp Glu Leu Tyr Lys 
        755                 


<210>  58
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln 
                245                 250                 255     


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
            260                 265                 270         


Cys Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln 
        275                 280                 285             


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
    290                 295                 300                 


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
305                 310                 315                 320 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
                325                 330                 335     


Tyr Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr 
            340                 345                 350         


Lys Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
    370                 375                 380                 


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
385                 390                 395                 400 


Ser Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn 
            420                 425                 430         


Tyr Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
        435                 440                 445             


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
    450                 455                 460                 


Ala Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr 
465                 470                 475                 480 


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                485                 490                 495     


Thr Lys 
        


<210>  59
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu 
                245                 250                 255     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            260                 265                 270         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        275                 280                 285             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    290                 295                 300                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
305                 310                 315                 320 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                325                 330                 335     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            340                 345                 350         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        355                 360                 365             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    370                 375                 380                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
385                 390                 395                 400 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                405                 410                 415     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            420                 425                 430         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        435                 440                 445             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    450                 455                 460                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
465                 470                 475                 480 


His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro 
                485                 490                 495     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            500                 505                 510         


Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
        515                 520                 525             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
    530                 535                 540                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
545                 550                 555                 560 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                565                 570                 575     


Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val 
            580                 585                 590         


Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        595                 600                 605             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    610                 615                 620                 


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
625                 630                 635                 640 


Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
                645                 650                 655     


Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala 
            660                 665                 670         


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
        675                 680                 685             


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
    690                 695                 700                 


Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp 
705                 710                 715                 720 


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
                725                 730                 735     


<210>  60
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys 
    530                 535                 540                 


Tyr Leu Leu Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val 
545                 550                 555                 560 


Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn 
                565                 570                 575     


Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr 
            580                 585                 590         


Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val 
        595                 600                 605             


Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu 
    610                 615                 620                 


Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala 
625                 630                 635                 640 


Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val 
                645                 650                 655     


Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp 
            660                 665                 670         


Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp 
        675                 680                 685             


Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys 
    690                 695                 700                 


Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys 
705                 710                 715                 720 


Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr 
                725                 730                 735     


Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu 
            740                 745                 750         


Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val 
        755                 760                 765             


Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    770                 775                 780                 


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
785                 790                 795                 800 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                805                 810                 815     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            820                 825                 830         


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        835                 840                 845             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    850                 855                 860                 


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
865                 870                 875                 880 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                885                 890                 895     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
            900                 905                 910         


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
        915                 920                 925             


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
    930                 935                 940                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
945                 950                 955                 960 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
                965                 970                 975     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
            980                 985                 990         


Val Thr Ala Ala Gly Ile Thr His  Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000                 1005         


<210>  61
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Val 
        275                 280                 285             


Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn Phe 
    290                 295                 300                 


Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu 
305                 310                 315                 320 


Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp 
                325                 330                 335     


Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala 
            340                 345                 350         


Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala 
        355                 360                 365             


Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val 
    370                 375                 380                 


Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn 
385                 390                 395                 400 


Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu 
                405                 410                 415     


Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val 
            420                 425                 430         


Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr 
        435                 440                 445             


Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser 
    450                 455                 460                 


Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp 
465                 470                 475                 480 


Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val 
                485                 490                 495     


Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys 
            500                 505                 510         


Cys Gly Ile Arg Asn Ser Ser Val Tyr 
        515                 520     


<210>  62
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu Thr Gln 
                245                 250                 255     


Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys 
            260                 265                 270         


Ser Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys 
        275                 280                 285             


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro 
    290                 295                 300                 


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
                325                 330                 335     


Cys Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr 
            340                 345                 350         


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
    370                 375                 380                 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
385                 390                 395                 400 


Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln 
                405                 410                 415     


Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser 
            420                 425                 430         


Lys Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile 
        435                 440                 445             


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
    450                 455                 460                 


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro 
465                 470                 475                 480 


Phe Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Ala Ser Thr Lys 
            500     


<210>  63
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu 
                245                 250                 255     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            260                 265                 270         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        275                 280                 285             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    290                 295                 300                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
305                 310                 315                 320 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                325                 330                 335     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            340                 345                 350         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        355                 360                 365             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    370                 375                 380                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
385                 390                 395                 400 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                405                 410                 415     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            420                 425                 430         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        435                 440                 445             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    450                 455                 460                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
465                 470                 475                 480 


His Gly Met Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln Pro Pro 
                485                 490                 495     


Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly 
            500                 505                 510         


Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly 
        515                 520                 525             


Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly 
    530                 535                 540                 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
545                 550                 555                 560 


Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
                565                 570                 575     


Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu 
            580                 585                 590         


Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
    610                 615                 620                 


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
625                 630                 635                 640 


Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro 
                645                 650                 655     


Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp 
            660                 665                 670         


Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
        675                 680                 685             


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr 
705                 710                 715                 720 


Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730                 735     


Ser Thr Lys 
            


<210>  64
<211>  1010
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Val Glu Gly Cys Thr Lys 
    530                 535                 540                 


Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn Phe Val Phe Trp Leu Ala 
545                 550                 555                 560 


Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln 
                565                 570                 575     


Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn 
            580                 585                 590         


Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met 
        595                 600                 605             


Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln 
    610                 615                 620                 


Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala Cys 
625                 630                 635                 640 


Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala 
                645                 650                 655     


Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val 
            660                 665                 670         


Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe His Glu 
        675                 680                 685             


Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser 
    690                 695                 700                 


Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn 
705                 710                 715                 720 


Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly 
                725                 730                 735     


Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met 
            740                 745                 750         


Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn 
        755                 760                 765             


Ser Ser Val Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
    770                 775                 780                 


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser 
785                 790                 795                 800 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                805                 810                 815     


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
            820                 825                 830         


Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
        835                 840                 845             


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
    850                 855                 860                 


Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr 
865                 870                 875                 880 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
                885                 890                 895     


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
            900                 905                 910         


Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
        915                 920                 925             


Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys 
    930                 935                 940                 


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
945                 950                 955                 960 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
                965                 970                 975     


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu 
            980                 985                 990         


Leu Glu Phe Val Thr Ala Ala Gly  Ile Thr His Gly Met  Asp Glu Leu 
        995                 1000                 1005             


Tyr Lys  
    1010 


<210>  65
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
    290                 295                 300                 


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
305                 310                 315                 320 


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
                325                 330                 335     


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
            340                 345                 350         


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
        355                 360                 365             


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
    370                 375                 380                 


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
385                 390                 395                 400 


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
                405                 410                 415     


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            420                 425                 430         


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        435                 440                 445             


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    450                 455                 460                 


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
465                 470                 475                 480 


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
                485                 490                 495     


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
            500                 505                 510         


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
        515                 520                 


<210>  66
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln 
                245                 250                 255     


Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr 
            260                 265                 270         


Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln 
        275                 280                 285             


Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu 
    290                 295                 300                 


Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln 
305                 310                 315                 320 


Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr 
                325                 330                 335     


Tyr Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr 
            340                 345                 350         


Lys Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
    370                 375                 380                 


Glu Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser 
385                 390                 395                 400 


Gly Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro 
                405                 410                 415     


Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg 
            420                 425                 430         


Ile Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
    450                 455                 460                 


Asp Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr 
465                 470                 475                 480 


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser 
                485                 490                 495     


Thr Lys 
        


<210>  67
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Ser Phe Thr Lys 
225                 230                 235                 240 


Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu 
                245                 250                 255     


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
            260                 265                 270         


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
        275                 280                 285             


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
    290                 295                 300                 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
305                 310                 315                 320 


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
                325                 330                 335     


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
            340                 345                 350         


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
        355                 360                 365             


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
    370                 375                 380                 


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
385                 390                 395                 400 


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
                405                 410                 415     


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
            420                 425                 430         


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
        435                 440                 445             


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
    450                 455                 460                 


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
465                 470                 475                 480 


His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro 
                485                 490                 495     


Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg 
            500                 505                 510         


Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln 
        515                 520                 525             


Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp 
    530                 535                 540                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser 
545                 550                 555                 560 


Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys 
                565                 570                 575     


Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
            580                 585                 590         


Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
    610                 615                 620                 


Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
625                 630                 635                 640 


Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln 
                645                 650                 655     


Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn 
            660                 665                 670         


Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser 
        675                 680                 685             


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
    690                 695                 700                 


Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro 
705                 710                 715                 720 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
                725                 730                 735     


<210>  68
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys 
    530                 535                 540                 


Tyr Leu Leu Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val 
545                 550                 555                 560 


Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn 
                565                 570                 575     


Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr 
            580                 585                 590         


Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val 
        595                 600                 605             


Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu 
    610                 615                 620                 


Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala 
625                 630                 635                 640 


Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val 
                645                 650                 655     


Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp 
            660                 665                 670         


Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp 
        675                 680                 685             


Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys 
    690                 695                 700                 


Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys 
705                 710                 715                 720 


Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr 
                725                 730                 735     


Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu 
            740                 745                 750         


Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val 
        755                 760                 765             


Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    770                 775                 780                 


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
785                 790                 795                 800 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                805                 810                 815     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            820                 825                 830         


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        835                 840                 845             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    850                 855                 860                 


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
865                 870                 875                 880 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                885                 890                 895     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
            900                 905                 910         


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
        915                 920                 925             


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
    930                 935                 940                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
945                 950                 955                 960 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
                965                 970                 975     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe 
            980                 985                 990         


Val Thr Ala Ala Gly Ile Thr His  Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000                 1005         


<210>  69
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Val 
        275                 280                 285             


Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val Phe Asn Phe 
    290                 295                 300                 


Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu 
305                 310                 315                 320 


Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp 
                325                 330                 335     


Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala 
            340                 345                 350         


Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala 
        355                 360                 365             


Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val 
    370                 375                 380                 


Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn 
385                 390                 395                 400 


Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu 
                405                 410                 415     


Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val 
            420                 425                 430         


Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr 
        435                 440                 445             


Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser 
    450                 455                 460                 


Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp 
465                 470                 475                 480 


Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val 
                485                 490                 495     


Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys 
            500                 505                 510         


Cys Gly Ile Arg Asn Ser Ser Val Tyr 
        515                 520     


<210>  70
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Lys Ile Ser Pro 
            260                 265                 270         


Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser 
        275                 280                 285             


Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg 
    290                 295                 300                 


Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser 
305                 310                 315                 320 


Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu Phe Thr 
                325                 330                 335     


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
            340                 345                 350         


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
        355                 360                 365             


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
    370                 375                 380                 


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
385                 390                 395                 400 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                405                 410                 415     


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
            420                 425                 430         


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
        435                 440                 445             


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
    450                 455                 460                 


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
465                 470                 475                 480 


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
                485                 490                 495     


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
            500                 505                 510         


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
        515                 520                 525             


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
    530                 535                 540                 


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
545                 550                 555                 560 


Asp Glu Leu Tyr Lys 
                565 


<210>  71
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe 
        275                 280                 285             


Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe 
    290                 295                 300                 


Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln 
305                 310                 315                 320 


Thr Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val 
                325                 330                 335     


Gly Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val 
            340                 345                 350         


Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu 
        355                 360                 365             


Ile Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met 
    370                 375                 380                 


Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg 
385                 390                 395                 400 


Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr 
                405                 410                 415     


Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp 
            420                 425                 430         


Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys 
        435                 440                 445             


Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys 
    450                 455                 460                 


Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro 
465                 470                 475                 480 


Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala 
                485                 490                 495     


Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val 
            500                 505                 510         


Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg 
        515                 520                 525             


His Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Lys Ile 
    530                 535                 540                 


Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg 
545                 550                 555                 560 


Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr 
                565                 570                 575     


Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu 
            580                 585                 590         


Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu 
        595                 600                 605             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    610                 615                 620                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
625                 630                 635                 640 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                645                 650                 655     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            660                 665                 670         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        675                 680                 685             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    690                 695                 700                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
705                 710                 715                 720 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                725                 730                 735     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            740                 745                 750         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        755                 760                 765             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    770                 775                 780                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
785                 790                 795                 800 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                805                 810                 815     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            820                 825                 830         


Gly Met Asp Glu Leu Tyr Lys 
        835                 


<210>  72
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Gly 
                325                 330                 335     


Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu 
            340                 345                 350         


Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile 
        355                 360                 365             


Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser Ser Ser 
    370                 375                 380                 


Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr 
385                 390                 395                 400 


Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg 
                405                 410                 415     


Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala 
            420                 425                 430         


Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys 
        435                 440                 445             


Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser 
    450                 455                 460                 


Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln 
465                 470                 475                 480 


Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala 
                485                 490                 495     


Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys Glu Val 
            500                 505                 510         


Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu 
        515                 520                 525             


Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp Trp Pro 
    530                 535                 540                 


Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu Gln Glu 
545                 550                 555                 560 


Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile Ile Glu 
                565                 570                 575     


Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser 
            580                 585                 590         


Glu Asp Tyr Ser Lys Val Pro Lys Tyr Met Ser Lys Gly Glu Glu Leu 
        595                 600                 605             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    610                 615                 620                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
625                 630                 635                 640 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                645                 650                 655     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            660                 665                 670         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        675                 680                 685             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    690                 695                 700                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
705                 710                 715                 720 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                725                 730                 735     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            740                 745                 750         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        755                 760                 765             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    770                 775                 780                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
785                 790                 795                 800 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                805                 810                 815     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            820                 825                 830         


Gly Met Asp Glu Leu Tyr Lys 
        835                 


<210>  73
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Arg Ile Ser Pro 
            260                 265                 270         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        275                 280                 285             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    290                 295                 300                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Met Ser 
305                 310                 315                 320 


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
                325                 330                 335     


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
            340                 345                 350         


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
        355                 360                 365             


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
    370                 375                 380                 


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
385                 390                 395                 400 


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
                405                 410                 415     


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
            420                 425                 430         


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
        435                 440                 445             


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
    450                 455                 460                 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
465                 470                 475                 480 


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
                485                 490                 495     


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
            500                 505                 510         


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
        515                 520                 525             


Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala 
    530                 535                 540                 


Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
545                 550                 555     


<210>  74
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe 
        275                 280                 285             


Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe 
    290                 295                 300                 


Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln 
305                 310                 315                 320 


Thr Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val 
                325                 330                 335     


Gly Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val 
            340                 345                 350         


Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu 
        355                 360                 365             


Ile Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met 
    370                 375                 380                 


Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg 
385                 390                 395                 400 


Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr 
                405                 410                 415     


Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp 
            420                 425                 430         


Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys 
        435                 440                 445             


Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys 
    450                 455                 460                 


Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro 
465                 470                 475                 480 


Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala 
                485                 490                 495     


Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val 
            500                 505                 510         


Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg 
        515                 520                 525             


His Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Arg Ile 
    530                 535                 540                 


Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser 
545                 550                 555                 560 


Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp 
                565                 570                 575     


Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln 
            580                 585                 590         


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        595                 600                 605             


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
    610                 615                 620                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
625                 630                 635                 640 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
                645                 650                 655     


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
            660                 665                 670         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        675                 680                 685             


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    690                 695                 700                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
705                 710                 715                 720 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
                725                 730                 735     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
            740                 745                 750         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
        755                 760                 765             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    770                 775                 780                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
785                 790                 795                 800 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
                805                 810                 815     


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            820                 825                 830 


<210>  75
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr 
                325                 330                 335     


Phe Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile 
            340                 345                 350         


Leu Gly Phe Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser 
        355                 360                 365             


Val Leu Gln Thr Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe 
    370                 375                 380                 


Ile Gly Val Gly Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile 
385                 390                 395                 400 


Gly Ala Val Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe 
                405                 410                 415     


Leu Leu Leu Ile Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr 
            420                 425                 430         


Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu 
        435                 440                 445             


Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala 
    450                 455                 460                 


Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe 
465                 470                 475                 480 


Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr 
                485                 490                 495     


Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser 
            500                 505                 510         


Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly 
        515                 520                 525             


Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys 
    530                 535                 540                 


Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly 
545                 550                 555                 560 


Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys 
                565                 570                 575     


Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            580                 585                 590         


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        595                 600                 605             


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
    610                 615                 620                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
625                 630                 635                 640 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
                645                 650                 655     


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
            660                 665                 670         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        675                 680                 685             


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    690                 695                 700                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
705                 710                 715                 720 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
                725                 730                 735     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
            740                 745                 750         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
        755                 760                 765             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    770                 775                 780                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
785                 790                 795                 800 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
                805                 810                 815     


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            820                 825                 830 


<210>  76
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Arg Ile Ser Gly 
            260                 265                 270         


Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys 
        275                 280                 285             


Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro 
    290                 295                 300                 


Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu Phe 
305                 310                 315                 320 


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                325                 330                 335     


Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            340                 345                 350         


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        355                 360                 365             


Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser 
    370                 375                 380                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
385                 390                 395                 400 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly 
                405                 410                 415     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            420                 425                 430         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        435                 440                 445             


Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
    450                 455                 460                 


Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
465                 470                 475                 480 


His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
                485                 490                 495     


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
            500                 505                 510         


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
        515                 520                 525             


His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
    530                 535                 540                 


Met Asp Glu Leu Tyr Lys 
545                 550 


<210>  77
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu 
        275                 280                 285             


Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly 
    290                 295                 300                 


Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr 
305                 310                 315                 320 


Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly 
                325                 330                 335     


Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn 
            340                 345                 350         


Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile 
        355                 360                 365             


Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly 
    370                 375                 380                 


Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp 
385                 390                 395                 400 


Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val 
                405                 410                 415     


Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr 
            420                 425                 430         


Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser 
        435                 440                 445             


Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly 
    450                 455                 460                 


Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu 
465                 470                 475                 480 


Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp 
                485                 490                 495     


Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala 
            500                 505                 510         


Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His 
        515                 520                 525             


Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Asn Arg Ile Ser 
    530                 535                 540                 


Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu 
545                 550                 555                 560 


Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr 
                565                 570                 575     


Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu 
            580                 585                 590         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        595                 600                 605             


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    610                 615                 620                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
625                 630                 635                 640 


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
                645                 650                 655     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            660                 665                 670         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
        675                 680                 685             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    690                 695                 700                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
705                 710                 715                 720 


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                725                 730                 735     


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            740                 745                 750         


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        755                 760                 765             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    770                 775                 780                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
785                 790                 795                 800 


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
                805                 810                 815     


Gly Met Asp Glu Leu Tyr Lys 
            820             


<210>  78
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Gly 
305                 310                 315                 320 


Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu 
                325                 330                 335     


Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile 
            340                 345                 350         


Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser Ser Ser 
        355                 360                 365             


Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr 
    370                 375                 380                 


Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg 
385                 390                 395                 400 


Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala 
                405                 410                 415     


Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys 
            420                 425                 430         


Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser 
        435                 440                 445             


Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln 
    450                 455                 460                 


Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala 
465                 470                 475                 480 


Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys Glu Val 
                485                 490                 495     


Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu 
            500                 505                 510         


Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp Trp Pro 
        515                 520                 525             


Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu Gln Glu 
    530                 535                 540                 


Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile Ile Glu 
545                 550                 555                 560 


Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser 
                565                 570                 575     


Glu Asp Tyr Ser Lys Val Pro Lys Tyr Met Ser Lys Gly Glu Glu Leu 
            580                 585                 590         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        595                 600                 605             


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    610                 615                 620                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
625                 630                 635                 640 


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
                645                 650                 655     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            660                 665                 670         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
        675                 680                 685             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    690                 695                 700                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
705                 710                 715                 720 


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                725                 730                 735     


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            740                 745                 750         


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        755                 760                 765             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    770                 775                 780                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
785                 790                 795                 800 


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
                805                 810                 815     


Gly Met Asp Glu Leu Tyr Lys 
            820             


<210>  79
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
        275                 280                 285             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    290                 295                 300                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
305                 310                 315                 320 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                325                 330                 335     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            340                 345                 350         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        355                 360                 365             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    370                 375                 380                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
385                 390                 395                 400 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                405                 410                 415     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            420                 425                 430         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        435                 440                 445             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    450                 455                 460                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
465                 470                 475                 480 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                485                 490                 495     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            500                 505                 510         


Gly Met Asp Glu Leu Tyr Lys 
        515                 


<210>  80
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Ser 
        275                 280                 285             


Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu Ile 
    290                 295                 300                 


Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu 
305                 310                 315                 320 


Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser Ser Ser Ser 
                325                 330                 335     


Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr Met 
            340                 345                 350         


Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys 
        355                 360                 365             


Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln 
    370                 375                 380                 


Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln 
385                 390                 395                 400 


Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser 
                405                 410                 415     


Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln Val 
            420                 425                 430         


Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu 
        435                 440                 445             


Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys Glu Val Lys 
    450                 455                 460                 


Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu Ala 
465                 470                 475                 480 


Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp Trp Pro Val 
                485                 490                 495     


Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu Gln Glu Asn 
            500                 505                 510         


Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile Ile Glu Leu 
        515                 520                 525             


Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser Glu 
    530                 535                 540                 


Asp Tyr Ser Lys Val Pro Lys Tyr Met Ser Lys Gly Glu Glu Leu Phe 
545                 550                 555                 560 


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                565                 570                 575     


Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            580                 585                 590         


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        595                 600                 605             


Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser 
    610                 615                 620                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
625                 630                 635                 640 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly 
                645                 650                 655     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            660                 665                 670         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        675                 680                 685             


Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
    690                 695                 700                 


Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
705                 710                 715                 720 


His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
                725                 730                 735     


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
            740                 745                 750         


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
        755                 760                 765             


His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
    770                 775                 780                 


Met Asp Glu Leu Tyr Lys 
785                 790 


<210>  81
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser 
        275                 280                 285             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    290                 295                 300                 


Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
                325                 330                 335     


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            340                 345                 350         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        355                 360                 365             


Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys 
    370                 375                 380                 


Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                405                 410                 415     


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
            420                 425                 430         


Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
        435                 440                 445             


Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr 
    450                 455                 460                 


Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
465                 470                 475                 480 


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
                485                 490                 495     


Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe 
            500                 505                 510         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        515                 520                 525             


Lys 
    


<210>  82
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
        275                 280                 285             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    290                 295                 300                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
305                 310                 315                 320 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                325                 330                 335     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            340                 345                 350         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        355                 360                 365             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    370                 375                 380                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
385                 390                 395                 400 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                405                 410                 415     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            420                 425                 430         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        435                 440                 445             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    450                 455                 460                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
465                 470                 475                 480 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                485                 490                 495     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            500                 505                 510         


Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser 
        515                 520                 525             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    530                 535                 540                 


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
545                 550                 555                 560 


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
                565                 570                 575     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            580                 585                 590         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
        595                 600                 605             


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
    610                 615                 620                 


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                645                 650                 655     


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            660                 665                 670         


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
        675                 680                 685             


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
    690                 695                 700                 


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
705                 710                 715                 720 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
                725                 730                 735     


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        755                 760                 765         


<210>  83
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr 
    530                 535                 540                 


Phe Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile 
545                 550                 555                 560 


Leu Gly Phe Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser 
                565                 570                 575     


Val Leu Gln Thr Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe 
            580                 585                 590         


Ile Gly Val Gly Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile 
        595                 600                 605             


Gly Ala Val Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe 
    610                 615                 620                 


Leu Leu Leu Ile Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr 
625                 630                 635                 640 


Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu 
                645                 650                 655     


Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala 
            660                 665                 670         


Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe 
        675                 680                 685             


Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr 
    690                 695                 700                 


Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser 
705                 710                 715                 720 


Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly 
                725                 730                 735     


Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys 
            740                 745                 750         


Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly 
        755                 760                 765             


Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys 
    770                 775                 780                 


Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
785                 790                 795                 800 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
                805                 810                 815     


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
            820                 825                 830         


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        835                 840                 845             


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    850                 855                 860                 


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
865                 870                 875                 880 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                885                 890                 895     


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            900                 905                 910         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        915                 920                 925             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
    930                 935                 940                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
945                 950                 955                 960 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
                965                 970                 975     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            980                 985                 990         


Val Leu Leu Pro Asp Asn His Tyr  Leu Ser Thr Gln Ser  Ala Leu Ser 
        995                 1000                 1005             


Lys Asp  Pro Asn Glu Lys Arg  Asp His Met Ile Leu  Leu Glu Phe 
    1010                 1015                 1020             


Val Thr  Ala Ala Gly Ile Thr  His Gly Met Asp Glu  Leu Tyr Lys 
    1025                 1030                 1035             


<210>  84
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Ser 
        275                 280                 285             


Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu Ile 
    290                 295                 300                 


Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu 
305                 310                 315                 320 


Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser Ser Ser Ser 
                325                 330                 335     


Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr Met 
            340                 345                 350         


Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys 
        355                 360                 365             


Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln 
    370                 375                 380                 


Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln 
385                 390                 395                 400 


Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser 
                405                 410                 415     


Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln Val 
            420                 425                 430         


Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu 
        435                 440                 445             


Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys Glu Val Lys 
    450                 455                 460                 


Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu Ala 
465                 470                 475                 480 


Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp Trp Pro Val 
                485                 490                 495     


Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu Gln Glu Asn 
            500                 505                 510         


Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile Ile Glu Leu 
        515                 520                 525             


Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser Glu 
    530                 535                 540                 


Asp Tyr Ser Lys Val Pro Lys Tyr 
545                 550         


<210>  85
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu Thr Gln Pro 
        275                 280                 285             


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser 
    290                 295                 300                 


Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro 
305                 310                 315                 320 


Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser 
                325                 330                 335     


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
            340                 345                 350         


Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
        355                 360                 365             


Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys 
    370                 375                 380                 


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
                405                 410                 415     


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
            420                 425                 430         


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser 
        435                 440                 445             


Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys 
    450                 455                 460                 


Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
465                 470                 475                 480 


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
                485                 490                 495     


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe 
            500                 505                 510         


Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        515                 520                 525             


Ala Ser Thr Lys 
    530         


<210>  86
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
        275                 280                 285             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    290                 295                 300                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
305                 310                 315                 320 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                325                 330                 335     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            340                 345                 350         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        355                 360                 365             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    370                 375                 380                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
385                 390                 395                 400 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                405                 410                 415     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            420                 425                 430         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        435                 440                 445             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    450                 455                 460                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
465                 470                 475                 480 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                485                 490                 495     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            500                 505                 510         


Gly Met Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln Pro Pro Ser 
        515                 520                 525             


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
    530                 535                 540                 


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
                565                 570                 575     


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
            580                 585                 590         


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
        595                 600                 605             


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
    610                 615                 620                 


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
                645                 650                 655     


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
            660                 665                 670         


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
        675                 680                 685             


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
    690                 695                 700                 


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
705                 710                 715                 720 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
                725                 730                 735     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
            740                 745                 750         


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        755                 760                 765             


Thr Lys 
    770 


<210>  87
<211>  1041
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Ser Ala Cys Ile Lys Val 
    530                 535                 540                 


Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly 
545                 550                 555                 560 


Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu Ala Asp Lys Ser Ser 
                565                 570                 575     


Phe Ile Ser Val Leu Gln Thr Ser Ser Ser Ser Leu Arg Met Gly Ala 
            580                 585                 590         


Tyr Val Phe Ile Gly Val Gly Ala Val Thr Met Leu Met Gly Phe Leu 
        595                 600                 605             


Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr 
    610                 615                 620                 


Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln Val Thr Ala Gly Ala 
625                 630                 635                 640 


Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly Ile 
                645                 650                 655     


Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu 
            660                 665                 670         


Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp 
        675                 680                 685             


Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro 
    690                 695                 700                 


Glu Val Thr Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn 
705                 710                 715                 720 


Ser Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr 
                725                 730                 735     


Gln Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys 
            740                 745                 750         


Met Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu 
        755                 760                 765             


Gly Val Gly Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu 
    770                 775                 780                 


Ser Ile Cys Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val 
785                 790                 795                 800 


Pro Lys Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
                805                 810                 815     


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
            820                 825                 830         


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        835                 840                 845             


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    850                 855                 860                 


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
865                 870                 875                 880 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                885                 890                 895     


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            900                 905                 910         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        915                 920                 925             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
    930                 935                 940                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
945                 950                 955                 960 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
                965                 970                 975     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            980                 985                 990         


Asp Gly Pro Val Leu Leu Pro Asp  Asn His Tyr Leu Ser  Thr Gln Ser 
        995                 1000                 1005             


Ala Leu  Ser Lys Asp Pro Asn  Glu Lys Arg Asp His  Met Ile Leu 
    1010                 1015                 1020             


Leu Glu  Phe Val Thr Ala Ala  Gly Ile Thr His Gly  Met Asp Glu 
    1025                 1030                 1035             


Leu Tyr  Lys 
    1040     


<210>  88
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
    290                 295                 300                 


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
305                 310                 315                 320 


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
                325                 330                 335     


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
            340                 345                 350         


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
        355                 360                 365             


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
    370                 375                 380                 


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
385                 390                 395                 400 


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
                405                 410                 415     


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
            420                 425                 430         


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
        435                 440                 445             


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
    450                 455                 460                 


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
465                 470                 475                 480 


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
                485                 490                 495     


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
            500                 505                 510         


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
        515                 520                 525             


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
    530                 535                 540                 


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
545                 550                 555 


<210>  89
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser 
        275                 280                 285             


Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys 
    290                 295                 300                 


Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala 
                325                 330                 335     


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr 
            340                 345                 350         


Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr 
        355                 360                 365             


Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
    370                 375                 380                 


Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
                405                 410                 415     


Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly 
            420                 425                 430         


Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly 
        435                 440                 445             


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile 
    450                 455                 460                 


Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
                485                 490                 495     


Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe 
            500                 505                 510         


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
        515                 520                 525             


Lys 
    


<210>  90
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr Ser Phe Thr Lys Gln 
            260                 265                 270         


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
        275                 280                 285             


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
    290                 295                 300                 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
305                 310                 315                 320 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
                325                 330                 335     


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
            340                 345                 350         


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
        355                 360                 365             


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
    370                 375                 380                 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
385                 390                 395                 400 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
                405                 410                 415     


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
            420                 425                 430         


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
        435                 440                 445             


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
    450                 455                 460                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
465                 470                 475                 480 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                485                 490                 495     


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
            500                 505                 510         


Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ala 
        515                 520                 525             


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
    530                 535                 540                 


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
545                 550                 555                 560 


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
                565                 570                 575     


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
            580                 585                 590         


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
        595                 600                 605             


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
    610                 615                 620                 


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
                645                 650                 655     


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
            660                 665                 670         


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
        675                 680                 685             


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
    690                 695                 700                 


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
705                 710                 715                 720 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
                725                 730                 735     


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
        755                 760                 765         


<210>  91
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr 
    530                 535                 540                 


Phe Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile 
545                 550                 555                 560 


Leu Gly Phe Gly Val Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser 
                565                 570                 575     


Val Leu Gln Thr Ser Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe 
            580                 585                 590         


Ile Gly Val Gly Ala Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile 
        595                 600                 605             


Gly Ala Val Asn Glu Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe 
    610                 615                 620                 


Leu Leu Leu Ile Leu Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr 
625                 630                 635                 640 


Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu 
                645                 650                 655     


Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala 
            660                 665                 670         


Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe 
        675                 680                 685             


Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr 
    690                 695                 700                 


Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser 
705                 710                 715                 720 


Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly 
                725                 730                 735     


Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys 
            740                 745                 750         


Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly 
        755                 760                 765             


Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys 
    770                 775                 780                 


Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
785                 790                 795                 800 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
                805                 810                 815     


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
            820                 825                 830         


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        835                 840                 845             


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    850                 855                 860                 


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
865                 870                 875                 880 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                885                 890                 895     


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            900                 905                 910         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        915                 920                 925             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
    930                 935                 940                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
945                 950                 955                 960 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
                965                 970                 975     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            980                 985                 990         


Val Leu Leu Pro Asp Asn His Tyr  Leu Ser Thr Gln Ser  Ala Leu Ser 
        995                 1000                 1005             


Lys Asp  Pro Asn Glu Lys Arg  Asp His Met Ile Leu  Leu Glu Phe 
    1010                 1015                 1020             


Val Thr  Ala Ala Gly Ile Thr  His Gly Met Asp Glu  Leu Tyr Lys 
    1025                 1030                 1035             


<210>  92
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Ser 
        275                 280                 285             


Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe Asn Leu Ile 
    290                 295                 300                 


Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu 
305                 310                 315                 320 


Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser Ser Ser Ser 
                325                 330                 335     


Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Thr Met 
            340                 345                 350         


Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys 
        355                 360                 365             


Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln 
    370                 375                 380                 


Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln 
385                 390                 395                 400 


Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser 
                405                 410                 415     


Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln Val 
            420                 425                 430         


Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu 
        435                 440                 445             


Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys Glu Val Lys 
    450                 455                 460                 


Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu Ala 
465                 470                 475                 480 


Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp Trp Pro Val 
                485                 490                 495     


Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu Gln Glu Asn 
            500                 505                 510         


Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile Ile Glu Leu 
        515                 520                 525             


Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser Glu 
    530                 535                 540                 


Asp Tyr Ser Lys Val Pro Lys Tyr 
545                 550         


<210>  93
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Lys Ile Ser Pro Ser Gly 
        275                 280                 285             


Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser Val Glu 
    290                 295                 300                 


Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg Tyr Asp 
305                 310                 315                 320 


Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser Phe Met 
                325                 330                 335     


Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            340                 345                 350         


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe 
        355                 360                 365             


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    370                 375                 380                 


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
385                 390                 395                 400 


Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                405                 410                 415     


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            420                 425                 430         


Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys 
        435                 440                 445             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    450                 455                 460                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
465                 470                 475                 480 


Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
                485                 490                 495     


Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
            500                 505                 510         


Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        515                 520                 525             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    530                 535                 540                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile 
545                 550                 555                 560 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu 
                565                 570                 575     


Leu Tyr Lys 
            


<210>  94
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe 
        275                 280                 285             


Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe 
    290                 295                 300                 


Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe 
305                 310                 315                 320 


Val Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala 
                325                 330                 335     


Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly 
            340                 345                 350         


Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu 
        355                 360                 365             


Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr 
    370                 375                 380                 


Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr 
385                 390                 395                 400 


Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser 
                405                 410                 415     


Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro 
            420                 425                 430         


Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala 
        435                 440                 445             


His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser 
    450                 455                 460                 


Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His 
465                 470                 475                 480 


Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu 
                485                 490                 495     


Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu 
            500                 505                 510         


His Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu 
        515                 520                 525             


Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu 
    530                 535                 540                 


Asp His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Lys Ile Ser Pro 
545                 550                 555                 560 


Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser 
                565                 570                 575     


Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg 
            580                 585                 590         


Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser 
        595                 600                 605             


Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu Phe Thr 
    610                 615                 620                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
625                 630                 635                 640 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                645                 650                 655     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            660                 665                 670         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        675                 680                 685             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    690                 695                 700                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
705                 710                 715                 720 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                725                 730                 735     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            740                 745                 750         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        755                 760                 765             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    770                 775                 780                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
785                 790                 795                 800 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                805                 810                 815     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            820                 825                 830         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        835                 840                 845             


Asp Glu Leu Tyr Lys 
    850             


<210>  95
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser 
                325                 330                 335     


Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe 
            340                 345                 350         


Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile 
        355                 360                 365             


Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ala 
    370                 375                 380                 


Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser Gly Ile 
385                 390                 395                 400 


Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu 
                405                 410                 415     


Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe 
            420                 425                 430         


Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln 
        435                 440                 445             


Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr 
    450                 455                 460                 


Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val 
465                 470                 475                 480 


Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe 
                485                 490                 495     


Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro 
            500                 505                 510         


Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp 
        515                 520                 525             


Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser 
    530                 535                 540                 


Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr 
545                 550                 555                 560 


Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu 
                565                 570                 575     


Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly 
            580                 585                 590         


Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr 
        595                 600                 605             


Asn Arg Leu Ala Arg Tyr Arg Met Ser Lys Gly Glu Glu Leu Phe Thr 
    610                 615                 620                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
625                 630                 635                 640 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                645                 650                 655     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            660                 665                 670         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        675                 680                 685             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    690                 695                 700                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
705                 710                 715                 720 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                725                 730                 735     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            740                 745                 750         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        755                 760                 765             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    770                 775                 780                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
785                 790                 795                 800 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                805                 810                 815     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            820                 825                 830         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        835                 840                 845             


Asp Glu Leu Tyr Lys 
    850             


<210>  96
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Arg Ile Ser Pro Leu Val 
        275                 280                 285             


Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His 
    290                 295                 300                 


Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser Asn 
305                 310                 315                 320 


Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Met Ser Lys Gly 
                325                 330                 335     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            340                 345                 350         


Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        355                 360                 365             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    370                 375                 380                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val 
385                 390                 395                 400 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                405                 410                 415     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr 
            420                 425                 430         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        435                 440                 445             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    450                 455                 460                 


Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His 
465                 470                 475                 480 


Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn 
                485                 490                 495     


Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp 
            500                 505                 510         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        515                 520                 525             


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    530                 535                 540                 


Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly 
545                 550                 555                 560 


Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                565                 570 


<210>  97
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe 
        275                 280                 285             


Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe 
    290                 295                 300                 


Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe 
305                 310                 315                 320 


Val Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala 
                325                 330                 335     


Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly 
            340                 345                 350         


Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu 
        355                 360                 365             


Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr 
    370                 375                 380                 


Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr 
385                 390                 395                 400 


Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser 
                405                 410                 415     


Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro 
            420                 425                 430         


Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala 
        435                 440                 445             


His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser 
    450                 455                 460                 


Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His 
465                 470                 475                 480 


Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu 
                485                 490                 495     


Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu 
            500                 505                 510         


His Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu 
        515                 520                 525             


Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu 
    530                 535                 540                 


Asp His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Arg Ile Ser Pro 
545                 550                 555                 560 


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
                565                 570                 575     


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
            580                 585                 590         


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Met Ser 
        595                 600                 605             


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
    610                 615                 620                 


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
625                 630                 635                 640 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
                645                 650                 655     


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
            660                 665                 670         


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
        675                 680                 685             


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
    690                 695                 700                 


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
705                 710                 715                 720 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
                725                 730                 735     


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
            740                 745                 750         


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
        755                 760                 765             


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
    770                 775                 780                 


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
785                 790                 795                 800 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
                805                 810                 815     


Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala 
            820                 825                 830         


Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        835                 840                 


<210>  98
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile 
                325                 330                 335     


Lys Tyr Phe Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser 
            340                 345                 350         


Leu Ile Phe Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe 
        355                 360                 365             


Val Ser Phe Val Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys 
    370                 375                 380                 


Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly 
385                 390                 395                 400 


Cys Val Gly Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe 
                405                 410                 415     


Gly Met Leu Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu 
            420                 425                 430         


Ile Ser Thr Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val 
        435                 440                 445             


Glu Lys Thr Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala 
    450                 455                 460                 


Glu Glu Ser Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp 
465                 470                 475                 480 


His Tyr Pro Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly 
                485                 490                 495     


Ser Glu Ala His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr 
            500                 505                 510         


Asn Asp Ser Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg 
        515                 520                 525             


Leu Gly His Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val 
    530                 535                 540                 


Pro Ala Glu Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln 
545                 550                 555                 560 


Lys Trp Leu His Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly 
                565                 570                 575     


Val Gly Leu Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys 
            580                 585                 590         


Arg Asn Leu Asp His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Met Ser 
        595                 600                 605             


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
    610                 615                 620                 


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
625                 630                 635                 640 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
                645                 650                 655     


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
            660                 665                 670         


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
        675                 680                 685             


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
    690                 695                 700                 


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
705                 710                 715                 720 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
                725                 730                 735     


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
            740                 745                 750         


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
        755                 760                 765             


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
    770                 775                 780                 


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
785                 790                 795                 800 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
                805                 810                 815     


Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala 
            820                 825                 830         


Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        835                 840                 


<210>  99
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Arg Ile Ser Gly Ala Ser 
        275                 280                 285             


Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp 
    290                 295                 300                 


Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser 
305                 310                 315                 320 


Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu Phe Thr Gly 
                325                 330                 335     


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys 
            340                 345                 350         


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
        355                 360                 365             


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
    370                 375                 380                 


Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
385                 390                 395                 400 


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
                405                 410                 415     


Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr 
            420                 425                 430         


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
        435                 440                 445             


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
    450                 455                 460                 


His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
465                 470                 475                 480 


Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
                485                 490                 495     


Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
            500                 505                 510         


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
        515                 520                 525             


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
    530                 535                 540                 


Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp 
545                 550                 555                 560 


Glu Leu Tyr Lys 
                


<210>  100
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu 
        275                 280                 285             


Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys 
    290                 295                 300                 


Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val 
305                 310                 315                 320 


Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile 
                325                 330                 335     


Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala 
            340                 345                 350         


Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu 
        355                 360                 365             


Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln 
    370                 375                 380                 


Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile 
385                 390                 395                 400 


Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp 
                405                 410                 415     


Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln 
            420                 425                 430         


Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His 
        435                 440                 445             


Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr 
    450                 455                 460                 


Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu 
465                 470                 475                 480 


Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser 
                485                 490                 495     


His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His 
            500                 505                 510         


Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu 
        515                 520                 525             


Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp 
    530                 535                 540                 


His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Asn Arg Ile Ser Gly Ala 
545                 550                 555                 560 


Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val 
                565                 570                 575     


Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser 
            580                 585                 590         


Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu Phe Thr 
        595                 600                 605             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
    610                 615                 620                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
625                 630                 635                 640 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                645                 650                 655     


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
            660                 665                 670         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        675                 680                 685             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
    690                 695                 700                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
705                 710                 715                 720 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                725                 730                 735     


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
            740                 745                 750         


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
        755                 760                 765             


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    770                 775                 780                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
785                 790                 795                 800 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                805                 810                 815     


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
            820                 825                 830         


Asp Glu Leu Tyr Lys 
        835         


<210>  101
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser 
305                 310                 315                 320 


Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe 
                325                 330                 335     


Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile 
            340                 345                 350         


Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ala 
        355                 360                 365             


Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser Gly Ile 
    370                 375                 380                 


Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu 
385                 390                 395                 400 


Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe 
                405                 410                 415     


Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln 
            420                 425                 430         


Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr 
        435                 440                 445             


Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val 
    450                 455                 460                 


Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe 
465                 470                 475                 480 


Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro 
                485                 490                 495     


Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp 
            500                 505                 510         


Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser 
        515                 520                 525             


Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr 
    530                 535                 540                 


Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu 
545                 550                 555                 560 


Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly 
                565                 570                 575     


Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr 
            580                 585                 590         


Asn Arg Leu Ala Arg Tyr Arg Met Ser Lys Gly Glu Glu Leu Phe Thr 
        595                 600                 605             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
    610                 615                 620                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
625                 630                 635                 640 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                645                 650                 655     


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
            660                 665                 670         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        675                 680                 685             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
    690                 695                 700                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
705                 710                 715                 720 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                725                 730                 735     


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
            740                 745                 750         


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
        755                 760                 765             


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    770                 775                 780                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
785                 790                 795                 800 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                805                 810                 815     


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
            820                 825                 830         


Asp Glu Leu Tyr Lys 
        835         


<210>  102
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr 
    290                 295                 300                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
305                 310                 315                 320 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                325                 330                 335     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            340                 345                 350         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        355                 360                 365             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    370                 375                 380                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
385                 390                 395                 400 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                405                 410                 415     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            420                 425                 430         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        435                 440                 445             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    450                 455                 460                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
465                 470                 475                 480 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                485                 490                 495     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            500                 505                 510         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        515                 520                 525             


Asp Glu Leu Tyr Lys 
    530             


<210>  103
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Ala 
        275                 280                 285             


Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe Asn 
    290                 295                 300                 


Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile Trp 
305                 310                 315                 320 


Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ala Phe 
                325                 330                 335     


Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser Gly Ile Phe 
            340                 345                 350         


Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu 
        355                 360                 365             


Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala 
    370                 375                 380                 


Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu 
385                 390                 395                 400 


Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly 
                405                 410                 415     


Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln 
            420                 425                 430         


Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln 
        435                 440                 445             


Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys 
    450                 455                 460                 


Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys 
465                 470                 475                 480 


Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg 
                485                 490                 495     


His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg 
            500                 505                 510         


Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile 
        515                 520                 525             


Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe 
    530                 535                 540                 


Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn 
545                 550                 555                 560 


Arg Leu Ala Arg Tyr Arg Met Ser Lys Gly Glu Glu Leu Phe Thr Gly 
                565                 570                 575     


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys 
            580                 585                 590         


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
        595                 600                 605             


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
    610                 615                 620                 


Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
625                 630                 635                 640 


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
                645                 650                 655     


Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr 
            660                 665                 670         


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
        675                 680                 685             


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
    690                 695                 700                 


His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
705                 710                 715                 720 


Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
                725                 730                 735     


Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
            740                 745                 750         


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
        755                 760                 765             


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
    770                 775                 780                 


Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp 
785                 790                 795                 800 


Glu Leu Tyr Lys 
                


<210>  104
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser Pro Ser 
    290                 295                 300                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
305                 310                 315                 320 


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                325                 330                 335     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            340                 345                 350         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        355                 360                 365             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    370                 375                 380                 


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
385                 390                 395                 400 


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                405                 410                 415     


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            420                 425                 430         


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
        435                 440                 445             


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
    450                 455                 460                 


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
                485                 490                 495     


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
            500                 505                 510         


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
        515                 520                 525             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    530                 535                 540             


<210>  105
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr 
    290                 295                 300                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
305                 310                 315                 320 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                325                 330                 335     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            340                 345                 350         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        355                 360                 365             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    370                 375                 380                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
385                 390                 395                 400 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                405                 410                 415     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            420                 425                 430         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        435                 440                 445             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    450                 455                 460                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
465                 470                 475                 480 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                485                 490                 495     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            500                 505                 510         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        515                 520                 525             


Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    530                 535                 540                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
545                 550                 555                 560 


Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                565                 570                 575     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            580                 585                 590         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        595                 600                 605             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly 
    610                 615                 620                 


Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
625                 630                 635                 640 


Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
            660                 665                 670         


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
        675                 680                 685             


Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
    690                 695                 700                 


Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro Ser Phe 
705                 710                 715                 720 


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
                725                 730                 735     


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
            740                 745                 750         


Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser Trp Gly 
        755                 760                 765             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    770                 775                 780     


<210>  106
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile 
    530                 535                 540                 


Lys Tyr Phe Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser 
545                 550                 555                 560 


Leu Ile Phe Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe 
                565                 570                 575     


Val Ser Phe Val Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys 
            580                 585                 590         


Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly 
        595                 600                 605             


Cys Val Gly Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe 
    610                 615                 620                 


Gly Met Leu Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu 
625                 630                 635                 640 


Ile Ser Thr Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val 
                645                 650                 655     


Glu Lys Thr Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala 
            660                 665                 670         


Glu Glu Ser Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp 
        675                 680                 685             


His Tyr Pro Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly 
    690                 695                 700                 


Ser Glu Ala His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr 
705                 710                 715                 720 


Asn Asp Ser Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg 
                725                 730                 735     


Leu Gly His Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val 
            740                 745                 750         


Pro Ala Glu Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln 
        755                 760                 765             


Lys Trp Leu His Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly 
    770                 775                 780                 


Val Gly Leu Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys 
785                 790                 795                 800 


Arg Asn Leu Asp His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Met Ser 
                805                 810                 815     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            820                 825                 830         


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
        835                 840                 845             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    850                 855                 860                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
865                 870                 875                 880 


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
                885                 890                 895     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            900                 905                 910         


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        915                 920                 925             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    930                 935                 940                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
945                 950                 955                 960 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
                965                 970                 975     


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
            980                 985                 990         


Ala Asp His Tyr Gln Gln Asn Thr  Pro Ile Gly Asp Gly  Pro Val Leu 
        995                 1000                 1005             


Leu Pro  Asp Asn His Tyr Leu  Ser Thr Gln Ser Ala  Leu Ser Lys 
    1010                 1015                 1020             


Asp Pro  Asn Glu Lys Arg Asp  His Met Ile Leu Leu  Glu Phe Val 
    1025                 1030                 1035             


Thr Ala  Ala Gly Ile Thr His  Gly Met Asp Glu Leu  Tyr Lys 
    1040                 1045                 1050         


<210>  107
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Ala 
        275                 280                 285             


Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe Asn 
    290                 295                 300                 


Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile Trp 
305                 310                 315                 320 


Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ala Phe 
                325                 330                 335     


Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser Gly Ile Phe 
            340                 345                 350         


Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu 
        355                 360                 365             


Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala 
    370                 375                 380                 


Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu 
385                 390                 395                 400 


Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly 
                405                 410                 415     


Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln 
            420                 425                 430         


Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln 
        435                 440                 445             


Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys 
    450                 455                 460                 


Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys 
465                 470                 475                 480 


Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg 
                485                 490                 495     


His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg 
            500                 505                 510         


Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile 
        515                 520                 525             


Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe 
    530                 535                 540                 


Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn 
545                 550                 555                 560 


Arg Leu Ala Arg Tyr Arg 
                565     


<210>  108
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu Thr Gln Pro Pro Ser 
    290                 295                 300                 


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
305                 310                 315                 320 


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
                325                 330                 335     


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
            340                 345                 350         


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
        355                 360                 365             


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
    370                 375                 380                 


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
385                 390                 395                 400 


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
                405                 410                 415     


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
            420                 425                 430         


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
        435                 440                 445             


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
    450                 455                 460                 


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
465                 470                 475                 480 


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
                485                 490                 495     


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
            500                 505                 510         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
        515                 520                 525             


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    530                 535                 540                 


Thr Lys 
545     


<210>  109
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr 
    290                 295                 300                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
305                 310                 315                 320 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                325                 330                 335     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            340                 345                 350         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        355                 360                 365             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    370                 375                 380                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
385                 390                 395                 400 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                405                 410                 415     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            420                 425                 430         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        435                 440                 445             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    450                 455                 460                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
465                 470                 475                 480 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                485                 490                 495     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            500                 505                 510         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        515                 520                 525             


Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    530                 535                 540                 


Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile 
545                 550                 555                 560 


Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                565                 570                 575     


Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu 
            580                 585                 590         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        595                 600                 605             


Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp 
    610                 615                 620                 


Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
625                 630                 635                 640 


Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                645                 650                 655     


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
            660                 665                 670         


Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser 
        675                 680                 685             


Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly 
    690                 695                 700                 


Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr Asn Asn 
705                 710                 715                 720 


Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser 
                725                 730                 735     


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr 
            740                 745                 750         


Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser Ile Asp 
        755                 760                 765             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    770                 775                 780                 


<210>  110
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Ala Gln Glu Ser Cys Leu 
    530                 535                 540                 


Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe Asn Leu Phe Phe Phe Val 
545                 550                 555                 560 


Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys 
                565                 570                 575     


Thr Ser Phe Val Ser Phe Val Gly Leu Ala Phe Val Pro Leu Gln Ile 
            580                 585                 590         


Trp Ser Lys Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala 
        595                 600                 605             


Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly 
    610                 615                 620                 


Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu 
625                 630                 635                 640 


Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg 
                645                 650                 655     


Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu 
            660                 665                 670         


Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys 
        675                 680                 685             


Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln Val Leu Ile Leu Arg 
    690                 695                 700                 


Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys Ser Cys Tyr Asn Leu 
705                 710                 715                 720 


Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys Val Ile Leu Pro Gln 
                725                 730                 735     


Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg His Ser Ala Asp Ile 
            740                 745                 750         


Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg Glu Gly Cys Ala Gln 
        755                 760                 765             


Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile Ser Ile Val Gly Ile 
    770                 775                 780                 


Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe Met Thr Leu Ser Ile 
785                 790                 795                 800 


Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn Arg Leu Ala Arg Tyr 
                805                 810                 815     


Arg Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            820                 825                 830         


Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly 
        835                 840                 845             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    850                 855                 860                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
865                 870                 875                 880 


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
                885                 890                 895     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
            900                 905                 910         


Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        915                 920                 925             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    930                 935                 940                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr 
945                 950                 955                 960 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn 
                965                 970                 975     


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser 
            980                 985                 990         


Val Gln Leu Ala Asp His Tyr Gln  Gln Asn Thr Pro Ile  Gly Asp Gly 
        995                 1000                 1005             


Pro Val  Leu Leu Pro Asp Asn  His Tyr Leu Ser Thr  Gln Ser Ala 
    1010                 1015                 1020             


Leu Ser  Lys Asp Pro Asn Glu  Lys Arg Asp His Met  Ile Leu Leu 
    1025                 1030                 1035             


Glu Phe  Val Thr Ala Ala Gly  Ile Thr His Gly Met  Asp Glu Leu 
    1040                 1045                 1050             


Tyr Lys  
    1055 


<210>  111
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
    290                 295                 300                 


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
305                 310                 315                 320 


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
                325                 330                 335     


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
            340                 345                 350         


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
        355                 360                 365             


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
    370                 375                 380                 


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
385                 390                 395                 400 


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
                405                 410                 415     


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
            420                 425                 430         


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
        435                 440                 445             


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
    450                 455                 460                 


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
465                 470                 475                 480 


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
                485                 490                 495     


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
            500                 505                 510         


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
        515                 520                 525             


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
    530                 535                 540                 


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
545                 550                 555                 560 


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
                565                 


<210>  112
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser Pro Ala 
    290                 295                 300                 


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
305                 310                 315                 320 


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
                325                 330                 335     


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
            340                 345                 350         


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
        355                 360                 365             


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
    370                 375                 380                 


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
385                 390                 395                 400 


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
                405                 410                 415     


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
            420                 425                 430         


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
        435                 440                 445             


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
    450                 455                 460                 


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
465                 470                 475                 480 


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                485                 490                 495     


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            500                 505                 510         


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
        515                 520                 525             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    530                 535                 540             


<210>  113
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg Ser Phe Thr Lys Gln Ser Ile 
        275                 280                 285             


Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu Phe Thr 
    290                 295                 300                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
305                 310                 315                 320 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                325                 330                 335     


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            340                 345                 350         


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
        355                 360                 365             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    370                 375                 380                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
385                 390                 395                 400 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                405                 410                 415     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            420                 425                 430         


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
        435                 440                 445             


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
    450                 455                 460                 


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
465                 470                 475                 480 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                485                 490                 495     


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            500                 505                 510         


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
        515                 520                 525             


Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
    530                 535                 540                 


Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly 
545                 550                 555                 560 


Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser 
                565                 570                 575     


Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro 
            580                 585                 590         


Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile 
        595                 600                 605             


Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe 
    610                 615                 620                 


Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
625                 630                 635                 640 


Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                645                 650                 655     


Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Gln Pro 
            660                 665                 670         


Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr 
        675                 680                 685             


Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    690                 695                 700                 


Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr Asn Glu 
705                 710                 715                 720 


Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                725                 730                 735     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            740                 745                 750         


Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr Trp Gly 
        755                 760                 765             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    770                 775                 780     


<210>  114
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile 
    530                 535                 540                 


Lys Tyr Phe Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser 
545                 550                 555                 560 


Leu Ile Phe Cys Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe 
                565                 570                 575     


Val Ser Phe Val Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys 
            580                 585                 590         


Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly 
        595                 600                 605             


Cys Val Gly Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe 
    610                 615                 620                 


Gly Met Leu Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu 
625                 630                 635                 640 


Ile Ser Thr Gln Arg Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val 
                645                 650                 655     


Glu Lys Thr Ile Gln Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala 
            660                 665                 670         


Glu Glu Ser Trp Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp 
        675                 680                 685             


His Tyr Pro Gln Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly 
    690                 695                 700                 


Ser Glu Ala His Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr 
705                 710                 715                 720 


Asn Asp Ser Thr Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg 
                725                 730                 735     


Leu Gly His Leu Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val 
            740                 745                 750         


Pro Ala Glu Ser His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln 
        755                 760                 765             


Lys Trp Leu His Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly 
    770                 775                 780                 


Val Gly Leu Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys 
785                 790                 795                 800 


Arg Asn Leu Asp His Val Tyr Asn Arg Leu Ala Arg Tyr Arg Met Ser 
                805                 810                 815     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            820                 825                 830         


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
        835                 840                 845             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    850                 855                 860                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
865                 870                 875                 880 


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
                885                 890                 895     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            900                 905                 910         


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        915                 920                 925             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    930                 935                 940                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
945                 950                 955                 960 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
                965                 970                 975     


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
            980                 985                 990         


Ala Asp His Tyr Gln Gln Asn Thr  Pro Ile Gly Asp Gly  Pro Val Leu 
        995                 1000                 1005             


Leu Pro  Asp Asn His Tyr Leu  Ser Thr Gln Ser Ala  Leu Ser Lys 
    1010                 1015                 1020             


Asp Pro  Asn Glu Lys Arg Asp  His Met Ile Leu Leu  Glu Phe Val 
    1025                 1030                 1035             


Thr Ala  Ala Gly Ile Thr His  Gly Met Asp Glu Leu  Tyr Lys 
    1040                 1045                 1050         


<210>  115
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Ala 
        275                 280                 285             


Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe Val Phe Asn 
    290                 295                 300                 


Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly Ile Trp 
305                 310                 315                 320 


Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ala Phe 
                325                 330                 335     


Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser Gly Ile Phe 
            340                 345                 350         


Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu 
        355                 360                 365             


Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala 
    370                 375                 380                 


Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu 
385                 390                 395                 400 


Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly 
                405                 410                 415     


Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln 
            420                 425                 430         


Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln 
        435                 440                 445             


Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys 
    450                 455                 460                 


Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys 
465                 470                 475                 480 


Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg 
                485                 490                 495     


His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg 
            500                 505                 510         


Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile 
        515                 520                 525             


Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe 
    530                 535                 540                 


Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn 
545                 550                 555                 560 


Arg Leu Ala Arg Tyr Arg 
                565     


<210>  116
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Lys Ile Ser Pro 
    210                 215                 220                 


Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg Thr Ser 
225                 230                 235                 240 


Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg 
                245                 250                 255     


Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser 
            260                 265                 270         


Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu Phe Thr 
        275                 280                 285             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln 
    290                 295                 300                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
305                 310                 315                 320 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                325                 330                 335     


Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg 
            340                 345                 350         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        355                 360                 365             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn 
    370                 375                 380                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
385                 390                 395                 400 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                405                 410                 415     


Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
            420                 425                 430         


Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
        435                 440                 445             


Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    450                 455                 460                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
465                 470                 475                 480 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                485                 490                 495     


Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
            500                 505                 510         


Asp Glu Leu Tyr Lys 
        515         


<210>  117
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe 
        275                 280                 285             


Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe 
    290                 295                 300                 


Gly Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn 
305                 310                 315                 320 


Leu Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile 
                325                 330                 335     


Ile Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn 
            340                 345                 350         


Lys Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu 
        355                 360                 365             


Ala Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu 
    370                 375                 380                 


Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu 
                405                 410                 415     


Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro 
            420                 425                 430         


Ala Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala 
        435                 440                 445             


Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile 
    450                 455                 460                 


Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu 
465                 470                 475                 480 


Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Lys Ile 
                485                 490                 495     


Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg 
            500                 505                 510         


Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr 
        515                 520                 525             


Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu 
    530                 535                 540                 


Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu 
545                 550                 555                 560 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                565                 570                 575     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            580                 585                 590         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        595                 600                 605             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    610                 615                 620                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
625                 630                 635                 640 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                645                 650                 655     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            660                 665                 670         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        675                 680                 685             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    690                 695                 700                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
705                 710                 715                 720 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                725                 730                 735     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            740                 745                 750         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        755                 760                 765             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    770                 775                 780                 


Gly Met Asp Glu Leu Tyr Lys 
785                 790     


<210>  118
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Gly 
                325                 330                 335     


Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu 
            340                 345                 350         


Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu 
        355                 360                 365             


Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu 
    370                 375                 380                 


Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val 
385                 390                 395                 400 


Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu 
                405                 410                 415     


Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr 
            420                 425                 430         


Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val 
        435                 440                 445             


Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser 
    450                 455                 460                 


Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly 
465                 470                 475                 480 


Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro 
                485                 490                 495     


Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe 
            500                 505                 510         


His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val 
        515                 520                 525             


Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile 
    530                 535                 540                 


Asp Lys Thr Ser Gln Thr Ile Gly Leu Met Ser Lys Gly Glu Glu Leu 
545                 550                 555                 560 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                565                 570                 575     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            580                 585                 590         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        595                 600                 605             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    610                 615                 620                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
625                 630                 635                 640 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                645                 650                 655     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            660                 665                 670         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        675                 680                 685             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    690                 695                 700                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
705                 710                 715                 720 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                725                 730                 735     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            740                 745                 750         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        755                 760                 765             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    770                 775                 780                 


Gly Met Asp Glu Leu Tyr Lys 
785                 790     


<210>  119
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Arg Ile Ser Pro 
    210                 215                 220                 


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
225                 230                 235                 240 


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
                245                 250                 255     


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Met Ser 
            260                 265                 270         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        275                 280                 285             


Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu 
    290                 295                 300                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
305                 310                 315                 320 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr 
                325                 330                 335     


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            340                 345                 350         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        355                 360                 365             


Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    370                 375                 380                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
385                 390                 395                 400 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn 
                405                 410                 415     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys 
            420                 425                 430         


Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu 
        435                 440                 445             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    450                 455                 460                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
465                 470                 475                 480 


Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala 
                485                 490                 495     


Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            500                 505             


<210>  120
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe 
        275                 280                 285             


Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe 
    290                 295                 300                 


Gly Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn 
305                 310                 315                 320 


Leu Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile 
                325                 330                 335     


Ile Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn 
            340                 345                 350         


Lys Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu 
        355                 360                 365             


Ala Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu 
    370                 375                 380                 


Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu 
                405                 410                 415     


Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro 
            420                 425                 430         


Ala Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala 
        435                 440                 445             


Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile 
    450                 455                 460                 


Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu 
465                 470                 475                 480 


Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Arg Ile 
                485                 490                 495     


Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser 
            500                 505                 510         


Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp 
        515                 520                 525             


Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln 
    530                 535                 540                 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
545                 550                 555                 560 


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
                565                 570                 575     


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
            580                 585                 590         


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
        595                 600                 605             


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
    610                 615                 620                 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
625                 630                 635                 640 


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
                645                 650                 655     


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
            660                 665                 670         


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
        675                 680                 685             


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
    690                 695                 700                 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
705                 710                 715                 720 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
                725                 730                 735     


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
            740                 745                 750         


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
        755                 760                 765             


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    770                 775                 780         


<210>  121
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr 
                325                 330                 335     


Val Leu Phe Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile 
            340                 345                 350         


Leu Gly Phe Gly Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu 
        355                 360                 365             


Phe His Asn Leu Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val 
    370                 375                 380                 


Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile 
385                 390                 395                 400 


Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile 
                405                 410                 415     


Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu 
            420                 425                 430         


Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His 
        435                 440                 445             


Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln 
    450                 455                 460                 


Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser 
465                 470                 475                 480 


Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr 
                485                 490                 495     


Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile 
            500                 505                 510         


Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala 
        515                 520                 525             


Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    530                 535                 540                 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
545                 550                 555                 560 


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
                565                 570                 575     


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
            580                 585                 590         


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
        595                 600                 605             


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
    610                 615                 620                 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
625                 630                 635                 640 


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
                645                 650                 655     


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
            660                 665                 670         


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
        675                 680                 685             


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
    690                 695                 700                 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
705                 710                 715                 720 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
                725                 730                 735     


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
            740                 745                 750         


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
        755                 760                 765             


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    770                 775                 780         


<210>  122
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Arg Ile Ser Gly 
    210                 215                 220                 


Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys 
225                 230                 235                 240 


Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro 
                245                 250                 255     


Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu Phe 
            260                 265                 270         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        275                 280                 285             


Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    290                 295                 300                 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
305                 310                 315                 320 


Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser 
                325                 330                 335     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            340                 345                 350         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly 
        355                 360                 365             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    370                 375                 380                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
385                 390                 395                 400 


Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                405                 410                 415     


Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            420                 425                 430         


His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        435                 440                 445             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    450                 455                 460                 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
465                 470                 475                 480 


His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
                485                 490                 495     


Met Asp Glu Leu Tyr Lys 
            500         


<210>  123
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe 
        275                 280                 285             


Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly 
    290                 295                 300                 


Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu 
305                 310                 315                 320 


Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile 
                325                 330                 335     


Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys 
            340                 345                 350         


Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala 
        355                 360                 365             


Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn 
    370                 375                 380                 


Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser 
385                 390                 395                 400 


Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln 
                405                 410                 415     


Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala 
            420                 425                 430         


Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg 
        435                 440                 445             


Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys 
    450                 455                 460                 


Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn 
465                 470                 475                 480 


Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Asn Arg Ile Ser 
                485                 490                 495     


Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu 
            500                 505                 510         


Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr 
        515                 520                 525             


Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu Leu 
    530                 535                 540                 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
545                 550                 555                 560 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
                565                 570                 575     


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
            580                 585                 590         


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
        595                 600                 605             


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
    610                 615                 620                 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
625                 630                 635                 640 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                645                 650                 655     


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
            660                 665                 670         


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
        675                 680                 685             


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
    690                 695                 700                 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
705                 710                 715                 720 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                725                 730                 735     


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            740                 745                 750         


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
        755                 760                 765             


Gly Met Asp Glu Leu Tyr Lys 
    770                 775 


<210>  124
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Gly 
305                 310                 315                 320 


Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu 
                325                 330                 335     


Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu 
            340                 345                 350         


Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu 
        355                 360                 365             


Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val 
    370                 375                 380                 


Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu 
385                 390                 395                 400 


Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr 
                405                 410                 415     


Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val 
            420                 425                 430         


Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser 
        435                 440                 445             


Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly 
    450                 455                 460                 


Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro 
465                 470                 475                 480 


Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe 
                485                 490                 495     


His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val 
            500                 505                 510         


Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile 
        515                 520                 525             


Asp Lys Thr Ser Gln Thr Ile Gly Leu Met Ser Lys Gly Glu Glu Leu 
    530                 535                 540                 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
545                 550                 555                 560 


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
                565                 570                 575     


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
            580                 585                 590         


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
        595                 600                 605             


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
    610                 615                 620                 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
625                 630                 635                 640 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                645                 650                 655     


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
            660                 665                 670         


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
        675                 680                 685             


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
    690                 695                 700                 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
705                 710                 715                 720 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                725                 730                 735     


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            740                 745                 750         


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
        755                 760                 765             


Gly Met Asp Glu Leu Tyr Lys 
    770                 775 


<210>  125
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
225                 230                 235                 240 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                245                 250                 255     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            260                 265                 270         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        275                 280                 285             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    290                 295                 300                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
305                 310                 315                 320 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                325                 330                 335     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            340                 345                 350         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        355                 360                 365             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    370                 375                 380                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
385                 390                 395                 400 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                405                 410                 415     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            420                 425                 430         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        435                 440                 445             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    450                 455                 460                 


Gly Met Asp Glu Leu Tyr Lys 
465                 470     


<210>  126
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Met 
        275                 280                 285             


Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu Leu 
    290                 295                 300                 


Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu Leu 
305                 310                 315                 320 


Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu Thr 
                325                 330                 335     


Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val Ala 
            340                 345                 350         


Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met 
        355                 360                 365             


Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu 
    370                 375                 380                 


Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala 
385                 390                 395                 400 


Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr 
                405                 410                 415     


Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile 
            420                 425                 430         


Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser 
        435                 440                 445             


Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His 
    450                 455                 460                 


Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile 
465                 470                 475                 480 


Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp 
                485                 490                 495     


Lys Thr Ser Gln Thr Ile Gly Leu Met Ser Lys Gly Glu Glu Leu Phe 
            500                 505                 510         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        515                 520                 525             


Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    530                 535                 540                 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
545                 550                 555                 560 


Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser 
                565                 570                 575     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            580                 585                 590         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly 
        595                 600                 605             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    610                 615                 620                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
625                 630                 635                 640 


Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                645                 650                 655     


Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            660                 665                 670         


His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        675                 680                 685             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    690                 695                 700                 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
705                 710                 715                 720 


His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys 
            740         


<210>  127
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser 
225                 230                 235                 240 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                245                 250                 255     


Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys 
            260                 265                 270         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        275                 280                 285             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    290                 295                 300                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
305                 310                 315                 320 


Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly 
            340                 345                 350         


Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        355                 360                 365             


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
    370                 375                 380                 


Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
385                 390                 395                 400 


Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr 
                405                 410                 415     


Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
            420                 425                 430         


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
        435                 440                 445             


Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe 
    450                 455                 460                 


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
465                 470                 475                 480 


Lys 
    


<210>  128
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
225                 230                 235                 240 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                245                 250                 255     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            260                 265                 270         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        275                 280                 285             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    290                 295                 300                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
305                 310                 315                 320 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                325                 330                 335     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            340                 345                 350         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        355                 360                 365             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    370                 375                 380                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
385                 390                 395                 400 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                405                 410                 415     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            420                 425                 430         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        435                 440                 445             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    450                 455                 460                 


Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser 
465                 470                 475                 480 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                485                 490                 495     


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            500                 505                 510         


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        515                 520                 525             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    530                 535                 540                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
545                 550                 555                 560 


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
                565                 570                 575     


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            580                 585                 590         


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
        595                 600                 605             


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
    610                 615                 620                 


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
625                 630                 635                 640 


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
                645                 650                 655     


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
            660                 665                 670         


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
        675                 680                 685             


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
    690                 695                 700                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
705                 710                 715                 


<210>  129
<211>  990
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr 
    530                 535                 540                 


Val Leu Phe Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile 
545                 550                 555                 560 


Leu Gly Phe Gly Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu 
                565                 570                 575     


Phe His Asn Leu Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val 
            580                 585                 590         


Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile 
        595                 600                 605             


Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile 
    610                 615                 620                 


Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu 
625                 630                 635                 640 


Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His 
                645                 650                 655     


Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln 
            660                 665                 670         


Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser 
        675                 680                 685             


Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr 
    690                 695                 700                 


Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile 
705                 710                 715                 720 


Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala 
                725                 730                 735     


Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            740                 745                 750         


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        755                 760                 765             


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
    770                 775                 780                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
785                 790                 795                 800 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
                805                 810                 815     


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
            820                 825                 830         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        835                 840                 845             


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    850                 855                 860                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
865                 870                 875                 880 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
                885                 890                 895     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
            900                 905                 910         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
        915                 920                 925             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    930                 935                 940                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
945                 950                 955                 960 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
                965                 970                 975     


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            980                 985                 990 


<210>  130
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Met 
        275                 280                 285             


Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu Leu 
    290                 295                 300                 


Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu Leu 
305                 310                 315                 320 


Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu Thr 
                325                 330                 335     


Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val Ala 
            340                 345                 350         


Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met 
        355                 360                 365             


Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu 
    370                 375                 380                 


Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala 
385                 390                 395                 400 


Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr 
                405                 410                 415     


Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile 
            420                 425                 430         


Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser 
        435                 440                 445             


Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His 
    450                 455                 460                 


Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile 
465                 470                 475                 480 


Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp 
                485                 490                 495     


Lys Thr Ser Gln Thr Ile Gly Leu 
            500                 


<210>  131
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu Thr Gln Pro 
225                 230                 235                 240 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser 
                245                 250                 255     


Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro 
            260                 265                 270         


Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser 
        275                 280                 285             


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
    290                 295                 300                 


Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
305                 310                 315                 320 


Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys 
                325                 330                 335     


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser 
            340                 345                 350         


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
        355                 360                 365             


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
    370                 375                 380                 


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser 
385                 390                 395                 400 


Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys 
                405                 410                 415     


Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
            420                 425                 430         


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
        435                 440                 445             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe 
    450                 455                 460                 


Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
465                 470                 475                 480 


Ala Ser Thr Lys 
                


<210>  132
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
225                 230                 235                 240 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                245                 250                 255     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            260                 265                 270         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        275                 280                 285             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    290                 295                 300                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
305                 310                 315                 320 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                325                 330                 335     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            340                 345                 350         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        355                 360                 365             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    370                 375                 380                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
385                 390                 395                 400 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                405                 410                 415     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            420                 425                 430         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        435                 440                 445             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    450                 455                 460                 


Gly Met Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln Pro Pro Ser 
465                 470                 475                 480 


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
                485                 490                 495     


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
            500                 505                 510         


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
        515                 520                 525             


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
    530                 535                 540                 


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
545                 550                 555                 560 


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
                565                 570                 575     


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
            580                 585                 590         


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
        595                 600                 605             


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
    610                 615                 620                 


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
625                 630                 635                 640 


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
                645                 650                 655     


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
            660                 665                 670         


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
        675                 680                 685             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
    690                 695                 700                 


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
705                 710                 715                 720 


Thr Lys 
        


<210>  133
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Met Ser Ser Leu Lys Leu 
    530                 535                 540                 


Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly 
545                 550                 555                 560 


Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu Leu Ile His Asn Asn Phe 
                565                 570                 575     


Gly Val Leu Phe His Asn Leu Pro Ser Leu Thr Leu Gly Asn Val Phe 
            580                 585                 590         


Val Ile Val Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys Met 
        595                 600                 605             


Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile Leu 
    610                 615                 620                 


Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu Phe 
625                 630                 635                 640 


Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp 
                645                 650                 655     


Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp 
            660                 665                 670         


Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp 
        675                 680                 685             


Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val Glu 
    690                 695                 700                 


Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu Tyr 
705                 710                 715                 720 


Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly Met 
                725                 730                 735     


Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr 
            740                 745                 750         


Ile Gly Leu Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        755                 760                 765             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val 
    770                 775                 780                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
785                 790                 795                 800 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                805                 810                 815     


Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
            820                 825                 830         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        835                 840                 845             


Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    850                 855                 860                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
865                 870                 875                 880 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met 
                885                 890                 895     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro 
            900                 905                 910         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp 
        915                 920                 925             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    930                 935                 940                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
945                 950                 955                 960 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu 
                965                 970                 975     


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
            980                 985                 990         


Lys 
    


<210>  134
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
    290                 295                 300                 


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
305                 310                 315                 320 


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
                325                 330                 335     


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
            340                 345                 350         


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
        355                 360                 365             


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
    370                 375                 380                 


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
385                 390                 395                 400 


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
                405                 410                 415     


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
            420                 425                 430         


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
        435                 440                 445             


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
    450                 455                 460                 


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
465                 470                 475                 480 


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
                485                 490                 495     


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            500                 505         


<210>  135
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr Gln Ser 
225                 230                 235                 240 


Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys 
                245                 250                 255     


Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
            260                 265                 270         


Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala 
        275                 280                 285             


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr 
    290                 295                 300                 


Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr 
305                 310                 315                 320 


Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
                325                 330                 335     


Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser 
            340                 345                 350         


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
        355                 360                 365             


Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly 
    370                 375                 380                 


Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly 
385                 390                 395                 400 


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile 
                405                 410                 415     


Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
        435                 440                 445             


Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe 
    450                 455                 460                 


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
465                 470                 475                 480 


Lys 
    


<210>  136
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu Ser Phe Thr Lys Gln 
    210                 215                 220                 


Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu Glu Leu 
225                 230                 235                 240 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                245                 250                 255     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            260                 265                 270         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        275                 280                 285             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    290                 295                 300                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
305                 310                 315                 320 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                325                 330                 335     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            340                 345                 350         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        355                 360                 365             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    370                 375                 380                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
385                 390                 395                 400 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                405                 410                 415     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            420                 425                 430         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        435                 440                 445             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    450                 455                 460                 


Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ala 
465                 470                 475                 480 


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
                485                 490                 495     


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
            500                 505                 510         


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
        515                 520                 525             


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
    530                 535                 540                 


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
545                 550                 555                 560 


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
                565                 570                 575     


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
            580                 585                 590         


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
        595                 600                 605             


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
    610                 615                 620                 


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
625                 630                 635                 640 


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
                645                 650                 655     


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
            660                 665                 670         


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
        675                 680                 685             


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
    690                 695                 700                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
705                 710                 715                 


<210>  137
<211>  990
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr 
    530                 535                 540                 


Val Leu Phe Phe Phe Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile 
545                 550                 555                 560 


Leu Gly Phe Gly Ile Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu 
                565                 570                 575     


Phe His Asn Leu Pro Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val 
            580                 585                 590         


Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile 
        595                 600                 605             


Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile 
    610                 615                 620                 


Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu 
625                 630                 635                 640 


Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His 
                645                 650                 655     


Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln 
            660                 665                 670         


Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser 
        675                 680                 685             


Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr 
    690                 695                 700                 


Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile 
705                 710                 715                 720 


Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala 
                725                 730                 735     


Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            740                 745                 750         


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        755                 760                 765             


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
    770                 775                 780                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
785                 790                 795                 800 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
                805                 810                 815     


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
            820                 825                 830         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        835                 840                 845             


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    850                 855                 860                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
865                 870                 875                 880 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
                885                 890                 895     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
            900                 905                 910         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
        915                 920                 925             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    930                 935                 940                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
945                 950                 955                 960 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
                965                 970                 975     


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            980                 985                 990 


<210>  138
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Met 
        275                 280                 285             


Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu Leu 
    290                 295                 300                 


Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu Leu 
305                 310                 315                 320 


Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu Thr 
                325                 330                 335     


Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val Ala 
            340                 345                 350         


Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met 
        355                 360                 365             


Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu 
    370                 375                 380                 


Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala 
385                 390                 395                 400 


Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr 
                405                 410                 415     


Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile 
            420                 425                 430         


Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser 
        435                 440                 445             


Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His 
    450                 455                 460                 


Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile 
465                 470                 475                 480 


Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp 
                485                 490                 495     


Lys Thr Ser Gln Thr Ile Gly Leu 
            500                 


<210>  139
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn Lys Ile 
                245                 250                 255     


Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala Arg 
            260                 265                 270         


Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His Tyr 
        275                 280                 285             


Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu 
    290                 295                 300                 


Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu Glu Leu 
305                 310                 315                 320 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
                325                 330                 335     


Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
            340                 345                 350         


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
        355                 360                 365             


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe 
    370                 375                 380                 


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
385                 390                 395                 400 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp 
                405                 410                 415     


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
            420                 425                 430         


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
        435                 440                 445             


Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
    450                 455                 460                 


Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
465                 470                 475                 480 


Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                485                 490                 495     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            500                 505                 510         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        515                 520                 525             


Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
    530                 535                 540                 


Gly Met Asp Glu Leu Tyr Lys 
545                 550     


<210>  140
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val 
        275                 280                 285             


Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala 
    290                 295                 300                 


Gly Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser 
305                 310                 315                 320 


Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr 
                325                 330                 335     


Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly 
            340                 345                 350         


Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe 
        355                 360                 365             


Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu 
    370                 375                 380                 


Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu 
385                 390                 395                 400 


Lys Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val 
                405                 410                 415     


Thr Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser 
            420                 425                 430         


Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu 
        435                 440                 445             


Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala 
    450                 455                 460                 


Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly 
465                 470                 475                 480 


Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val 
                485                 490                 495     


Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met 
            500                 505                 510         


Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn 
        515                 520                 525             


Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn 
    530                 535                 540                 


Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu 
545                 550                 555                 560 


His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn 
                565                 570                 575     


Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Ser Lys Gly Glu 
            580                 585                 590         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        595                 600                 605             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    610                 615                 620                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
625                 630                 635                 640 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                645                 650                 655     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            660                 665                 670         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        675                 680                 685             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    690                 695                 700                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
705                 710                 715                 720 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                725                 730                 735     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            740                 745                 750         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        755                 760                 765             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    770                 775                 780                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
785                 790                 795                 800 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                805                 810                 815     


Thr His Gly Met Asp Glu Leu Tyr Lys 
            820                 825 


<210>  141
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe 
        275                 280                 285             


Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu 
    290                 295                 300                 


Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg 
305                 310                 315                 320 


Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Met Gly 
                325                 330                 335     


Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr 
            340                 345                 350         


Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val 
        355                 360                 365             


Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser 
    370                 375                 380                 


Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val 
385                 390                 395                 400 


Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys Ala Thr 
                405                 410                 415     


Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu 
            420                 425                 430         


Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr 
        435                 440                 445             


Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp Thr Met 
    450                 455                 460                 


Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val 
465                 470                 475                 480 


Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln 
                485                 490                 495     


Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg 
            500                 505                 510         


Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys Gly Gln 
        515                 520                 525             


Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr 
    530                 535                 540                 


Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val 
545                 550                 555                 560 


Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys 
                565                 570                 575     


Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Met Ser Lys Gly Glu 
            580                 585                 590         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        595                 600                 605             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    610                 615                 620                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
625                 630                 635                 640 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                645                 650                 655     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            660                 665                 670         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        675                 680                 685             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    690                 695                 700                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
705                 710                 715                 720 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                725                 730                 735     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            740                 745                 750         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        755                 760                 765             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    770                 775                 780                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
785                 790                 795                 800 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                805                 810                 815     


Thr His Gly Met Asp Glu Leu Tyr Lys 
            820                 825 


<210>  142
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn Arg Ile 
                245                 250                 255     


Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser 
            260                 265                 270         


Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp 
        275                 280                 285             


Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln 
    290                 295                 300                 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
305                 310                 315                 320 


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
                325                 330                 335     


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
            340                 345                 350         


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
        355                 360                 365             


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
    370                 375                 380                 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
385                 390                 395                 400 


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
                405                 410                 415     


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
            420                 425                 430         


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
        435                 440                 445             


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly 
    450                 455                 460                 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
465                 470                 475                 480 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
                485                 490                 495     


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
            500                 505                 510         


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
        515                 520                 525             


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    530                 535                 540         


<210>  143
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val 
        275                 280                 285             


Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala 
    290                 295                 300                 


Gly Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser 
305                 310                 315                 320 


Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr 
                325                 330                 335     


Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly 
            340                 345                 350         


Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe 
        355                 360                 365             


Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu 
    370                 375                 380                 


Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu 
385                 390                 395                 400 


Lys Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val 
                405                 410                 415     


Thr Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser 
            420                 425                 430         


Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu 
        435                 440                 445             


Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala 
    450                 455                 460                 


Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly 
465                 470                 475                 480 


Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val 
                485                 490                 495     


Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met 
            500                 505                 510         


Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn 
        515                 520                 525             


Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser 
    530                 535                 540                 


Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu 
545                 550                 555                 560 


Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys 
                565                 570                 575     


Pro Gln Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            580                 585                 590         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
        595                 600                 605             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
    610                 615                 620                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
625                 630                 635                 640 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
                645                 650                 655     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            660                 665                 670         


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        675                 680                 685             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    690                 695                 700                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
705                 710                 715                 720 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
                725                 730                 735     


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
            740                 745                 750         


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        755                 760                 765             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
    770                 775                 780                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
785                 790                 795                 800 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815     


<210>  144
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Met Val Ser Lys Gly Glu 
            20                  25                  30          


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        35                  40                  45              


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    50                  55                  60                  


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
65                  70                  75                  80  


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
                85                  90                  95      


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            100                 105                 110         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        115                 120                 125             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    130                 135                 140                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                165                 170                 175     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            180                 185                 190         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        195                 200                 205             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    210                 215                 220                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
225                 230                 235                 240 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                245                 250                 255     


Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly 
            260                 265                 270         


Ser Arg Asn Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr 
        275                 280                 285             


Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr 
    290                 295                 300                 


Asp Phe Glu Phe Asp Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro 
305                 310                 315                 320 


Leu Ile Lys Pro Gln Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys 
                325                 330                 335     


Gly Thr Val Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe 
            340                 345                 350         


Trp Leu Ala Gly Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala 
        355                 360                 365             


Leu Lys Ser Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala 
    370                 375                 380                 


Thr Ala Tyr Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly 
385                 390                 395                 400 


Val Leu Gly Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg 
                405                 410                 415     


Leu Tyr Phe Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala 
            420                 425                 430         


Gly Ile Leu Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys 
        435                 440                 445             


Glu Asn Leu Lys Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His 
    450                 455                 460                 


Glu Ala Val Thr Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys 
465                 470                 475                 480 


Cys Gly Ser Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg 
                485                 490                 495     


Ser Gln Glu Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr 
            500                 505                 510         


Val Val Ala Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys 
        515                 520                 525             


Val Glu Gly Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His 
    530                 535                 540                 


Leu Arg Val Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val 
545                 550                 555                 560 


Phe Gly Met Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu 
                565                 570                 575     


His Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            580                 585                 590         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
        595                 600                 605             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
    610                 615                 620                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
625                 630                 635                 640 


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
                645                 650                 655     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            660                 665                 670         


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        675                 680                 685             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    690                 695                 700                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
705                 710                 715                 720 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
                725                 730                 735     


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
            740                 745                 750         


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        755                 760                 765             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
    770                 775                 780                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu 
785                 790                 795                 800 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815     


<210>  145
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn Arg Ile 
                245                 250                 255     


Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly 
            260                 265                 270         


Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp 
        275                 280                 285             


Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu Glu 
    290                 295                 300                 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
305                 310                 315                 320 


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
                325                 330                 335     


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
            340                 345                 350         


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
        355                 360                 365             


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
    370                 375                 380                 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
385                 390                 395                 400 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
                405                 410                 415     


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
            420                 425                 430         


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
        435                 440                 445             


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
    450                 455                 460                 


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
465                 470                 475                 480 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
                485                 490                 495     


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
            500                 505                 510         


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
        515                 520                 525             


His Gly Met Asp Glu Leu Tyr Lys 
    530                 535     


<210>  146
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys 
        275                 280                 285             


Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly 
    290                 295                 300                 


Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp 
305                 310                 315                 320 


Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile 
                325                 330                 335     


Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys 
            340                 345                 350         


Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile 
        355                 360                 365             


Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala 
    370                 375                 380                 


Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys 
385                 390                 395                 400 


Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr 
                405                 410                 415     


Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn 
            420                 425                 430         


Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala 
        435                 440                 445             


Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu 
    450                 455                 460                 


Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly 
465                 470                 475                 480 


Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile 
                485                 490                 495     


Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile 
            500                 505                 510         


Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Asn Arg 
        515                 520                 525             


Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu Ala Asp Gly 
    530                 535                 540                 


Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro Ala Pro Val 
545                 550                 555                 560 


Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Ser Lys Gly Glu 
                565                 570                 575     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            580                 585                 590         


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        595                 600                 605             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    610                 615                 620                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
625                 630                 635                 640 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                645                 650                 655     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
            660                 665                 670         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        675                 680                 685             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    690                 695                 700                 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
705                 710                 715                 720 


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
                725                 730                 735     


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
            740                 745                 750         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        755                 760                 765             


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    770                 775                 780                 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
785                 790                 795                 800 


Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 


<210>  147
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Met Val Ser Lys Gly Glu Glu 
            20                  25                  30          


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        35                  40                  45              


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    50                  55                  60                  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
65                  70                  75                  80  


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
                85                  90                  95      


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            100                 105                 110         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        115                 120                 125             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    130                 135                 140                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
145                 150                 155                 160 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                165                 170                 175     


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
            180                 185                 190         


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
        195                 200                 205             


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
    210                 215                 220                 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
225                 230                 235                 240 


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
                245                 250                 255     


Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser 
            260                 265                 270         


Arg Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly Glu 
        275                 280                 285             


Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala Pro 
    290                 295                 300                 


Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Met Gly 
305                 310                 315                 320 


Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr 
                325                 330                 335     


Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val 
            340                 345                 350         


Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser 
        355                 360                 365             


Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val 
    370                 375                 380                 


Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys Ala Thr 
385                 390                 395                 400 


Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu 
                405                 410                 415     


Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr 
            420                 425                 430         


Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp Thr Met 
        435                 440                 445             


Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val 
    450                 455                 460                 


Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln 
465                 470                 475                 480 


Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg 
                485                 490                 495     


Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys Gly Gln 
            500                 505                 510         


Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr 
        515                 520                 525             


Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val 
    530                 535                 540                 


Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys 
545                 550                 555                 560 


Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Met Ser Lys Gly Glu 
                565                 570                 575     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            580                 585                 590         


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        595                 600                 605             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    610                 615                 620                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
625                 630                 635                 640 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                645                 650                 655     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
            660                 665                 670         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        675                 680                 685             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    690                 695                 700                 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
705                 710                 715                 720 


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
                725                 730                 735     


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
            740                 745                 750         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        755                 760                 765             


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    770                 775                 780                 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
785                 790                 795                 800 


Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 


<210>  148
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu 
            260                 265                 270         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        275                 280                 285             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    290                 295                 300                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
305                 310                 315                 320 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                325                 330                 335     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            340                 345                 350         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        355                 360                 365             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    370                 375                 380                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
385                 390                 395                 400 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                405                 410                 415     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            420                 425                 430         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        435                 440                 445             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    450                 455                 460                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
465                 470                 475                 480 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                485                 490                 495     


Thr His Gly Met Asp Glu Leu Tyr Lys 
            500                 505 


<210>  149
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                165                 170                 175     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            180                 185                 190         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Glu 
        275                 280                 285             


Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr Leu 
    290                 295                 300                 


Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val Met 
305                 310                 315                 320 


Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val Ala 
            340                 345                 350         


Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys Ala Thr Phe 
        355                 360                 365             


Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu Ile 
    370                 375                 380                 


Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr Tyr 
385                 390                 395                 400 


Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp Thr Met Thr 
                405                 410                 415     


Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val Asp 
            420                 425                 430         


Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln Asp 
        435                 440                 445             


Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg Val 
    450                 455                 460                 


Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys Gly Gln Arg 
465                 470                 475                 480 


Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr Lys 
                485                 490                 495     


Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val Gly 
            500                 505                 510         


Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys Cys 
        515                 520                 525             


Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Met Ser Lys Gly Glu Glu 
    530                 535                 540                 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
545                 550                 555                 560 


Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
                565                 570                 575     


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
            580                 585                 590         


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
        595                 600                 605             


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
    610                 615                 620                 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp 
625                 630                 635                 640 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
                645                 650                 655     


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
            660                 665                 670         


Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val 
        675                 680                 685             


Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys 
    690                 695                 700                 


Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
705                 710                 715                 720 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
                725                 730                 735     


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
            740                 745                 750         


Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
        755                 760                 765             


His Gly Met Asp Glu Leu Tyr Lys 
    770                 775     


<210>  150
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
                405                 410                 415     


Tyr Ser Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr 
        435                 440                 445             


Asn Tyr Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
    450                 455                 460                 


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
465                 470                 475                 480 


Thr Ala Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp 
                485                 490                 495     


Thr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            500                 505                 510         


Ser Thr Lys 
        515 


<210>  151
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu 
            260                 265                 270         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        275                 280                 285             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    290                 295                 300                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
305                 310                 315                 320 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                325                 330                 335     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            340                 345                 350         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        355                 360                 365             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    370                 375                 380                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
385                 390                 395                 400 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                405                 410                 415     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            420                 425                 430         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        435                 440                 445             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    450                 455                 460                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
465                 470                 475                 480 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                485                 490                 495     


Thr His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser 
            500                 505                 510         


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        515                 520                 525             


Arg Ala Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
545                 550                 555                 560 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                565                 570                 575     


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            580                 585                 590         


Cys Gln Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys 
        595                 600                 605             


Val Glu Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
625                 630                 635                 640 


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
                645                 650                 655     


Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
            660                 665                 670         


Leu Glu Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr 
        675                 680                 685             


Ala Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
    690                 695                 700                 


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
705                 710                 715                 720 


Met Tyr Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe 
                725                 730                 735     


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            740                 745                 750         


Lys 
    


<210>  152
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys 
    530                 535                 540                 


Gly Thr Val Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe 
545                 550                 555                 560 


Trp Leu Ala Gly Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala 
                565                 570                 575     


Leu Lys Ser Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala 
            580                 585                 590         


Thr Ala Tyr Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly 
        595                 600                 605             


Val Leu Gly Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg 
    610                 615                 620                 


Leu Tyr Phe Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala 
625                 630                 635                 640 


Gly Ile Leu Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys 
                645                 650                 655     


Glu Asn Leu Lys Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His 
            660                 665                 670         


Glu Ala Val Thr Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys 
        675                 680                 685             


Cys Gly Ser Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg 
    690                 695                 700                 


Ser Gln Glu Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr 
705                 710                 715                 720 


Val Val Ala Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys 
                725                 730                 735     


Val Glu Gly Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His 
            740                 745                 750         


Leu Arg Val Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val 
        755                 760                 765             


Phe Gly Met Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu 
    770                 775                 780                 


His Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
785                 790                 795                 800 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
                805                 810                 815     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
            820                 825                 830         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        835                 840                 845             


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
    850                 855                 860                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
865                 870                 875                 880 


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                885                 890                 895     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            900                 905                 910         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
        915                 920                 925             


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
    930                 935                 940                 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
945                 950                 955                 960 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                965                 970                 975     


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
            980                 985                 990         


Leu Ser Lys Asp Pro Asn Glu Lys  Arg Asp His Met Ile  Leu Leu Glu 
        995                 1000                 1005             


Phe Val  Thr Ala Ala Gly Ile  Thr His Gly Met Asp  Glu Leu Tyr 
    1010                 1015                 1020             


Lys 
    


<210>  153
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Leu Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
                165                 170                 175     


Asn Tyr Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Phe Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ala Pro 
        195                 200                 205             


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Glu Leu Tyr Gln Gly Tyr Met Asp Thr Phe Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Glu 
        275                 280                 285             


Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr Leu 
    290                 295                 300                 


Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val Met 
305                 310                 315                 320 


Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val Ala 
            340                 345                 350         


Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys Ala Thr Phe 
        355                 360                 365             


Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu Ile 
    370                 375                 380                 


Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr Tyr 
385                 390                 395                 400 


Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp Thr Met Thr 
                405                 410                 415     


Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val Asp 
            420                 425                 430         


Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln Asp 
        435                 440                 445             


Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg Val 
    450                 455                 460                 


Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys Gly Gln Arg 
465                 470                 475                 480 


Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr Lys 
                485                 490                 495     


Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val Gly 
            500                 505                 510         


Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys Cys 
        515                 520                 525             


Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
    530                 535             


<210>  154
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Gln Ser Val Leu Thr 
            260                 265                 270         


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
        275                 280                 285             


Cys Ser Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg 
305                 310                 315                 320 


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
                325                 330                 335     


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
            340                 345                 350         


Tyr Cys Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile 
                405                 410                 415     


Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg 
            420                 425                 430         


Gln Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg 
        435                 440                 445             


Ser Lys Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr 
    450                 455                 460                 


Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser 
465                 470                 475                 480 


Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr 
                485                 490                 495     


Pro Phe Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            500                 505                 510         


Ser Ser Ala Ser Thr Lys 
        515             


<210>  155
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu 
            260                 265                 270         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        275                 280                 285             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    290                 295                 300                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
305                 310                 315                 320 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                325                 330                 335     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            340                 345                 350         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        355                 360                 365             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    370                 375                 380                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
385                 390                 395                 400 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                405                 410                 415     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            420                 425                 430         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        435                 440                 445             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    450                 455                 460                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
465                 470                 475                 480 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                485                 490                 495     


Thr His Gly Met Asp Glu Leu Tyr Lys Gln Ser Val Leu Thr Gln Pro 
            500                 505                 510         


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser 
        515                 520                 525             


Gly Asp Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
                565                 570                 575     


Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            580                 585                 590         


Ser Ser Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys 
        595                 600                 605             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
625                 630                 635                 640 


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
                645                 650                 655     


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser 
            660                 665                 670         


Pro Gly Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys 
        675                 680                 685             


Trp Tyr Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
    690                 695                 700                 


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
705                 710                 715                 720 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe 
                725                 730                 735     


Tyr Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Ala Ser Thr Lys 
        755     


<210>  156
<211>  1027
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser 
        515                 520                 525             


Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Glu Phe Asn Glu Lys Lys 
    530                 535                 540                 


Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn 
545                 550                 555                 560 


Cys Cys Phe Trp Leu Ala Gly Leu Ala Val Met Ala Val Gly Ile Trp 
                565                 570                 575     


Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr 
            580                 585                 590         


Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val Ala Gly Thr Val Val Met 
        595                 600                 605             


Val Thr Gly Val Leu Gly Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn 
    610                 615                 620                 


Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu 
625                 630                 635                 640 


Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr 
                645                 650                 655     


Glu Leu Lys Glu Asn Leu Lys Asp Thr Met Thr Lys Arg Tyr His Gln 
            660                 665                 670         


Pro Gly His Glu Ala Val Thr Ser Ala Val Asp Gln Leu Gln Gln Glu 
        675                 680                 685             


Phe His Cys Cys Gly Ser Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu 
    690                 695                 700                 


Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg Val Val Pro Asp Ser Cys 
705                 710                 715                 720 


Cys Lys Thr Val Val Ala Leu Cys Gly Gln Arg Asp His Ala Ser Asn 
                725                 730                 735     


Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile 
            740                 745                 750         


Gln Glu His Leu Arg Val Ile Gly Ala Val Gly Ile Gly Ile Ala Cys 
        755                 760                 765             


Val Gln Val Phe Gly Met Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu 
    770                 775                 780                 


Lys Leu Glu His Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
785                 790                 795                 800 


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe 
                805                 810                 815     


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
            820                 825                 830         


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
        835                 840                 845             


Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
    850                 855                 860                 


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
865                 870                 875                 880 


Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys 
                885                 890                 895     


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
            900                 905                 910         


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
        915                 920                 925             


Lys Met Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
    930                 935                 940                 


Lys Pro Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
945                 950                 955                 960 


Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
                965                 970                 975     


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
            980                 985                 990         


Gln Ser Ala Leu Ser Lys Asp Pro  Asn Glu Lys Arg Asp  His Met Ile 
        995                 1000                 1005             


Leu Leu  Glu Phe Val Thr Ala  Ala Gly Ile Thr His  Gly Met Asp 
    1010                 1015                 1020             


Glu Leu  Tyr Lys 
    1025         


<210>  157
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
        35                  40                  45              


Asn Ile Gly Ser Tyr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Val Leu Val Ile Tyr Glu Asp Ser Glu Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Asp Asp Pro Asn Phe Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
                165                 170                 175     


Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly 
            180                 185                 190         


Arg Gly Leu Glu Trp Leu Gly Ile Ile Gln Lys Arg Ser Lys Trp Tyr 
        195                 200                 205             


Asn Asn Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
    210                 215                 220                 


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Pro Phe Tyr Ser 
                245                 250                 255     


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            260                 265                 270         


Thr Lys Ser Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys 
        275                 280                 285             


Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
    290                 295                 300                 


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
305                 310                 315                 320 


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
                325                 330                 335     


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
            340                 345                 350         


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
        355                 360                 365             


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
    370                 375                 380                 


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
385                 390                 395                 400 


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
                405                 410                 415     


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
            420                 425                 430         


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
        435                 440                 445             


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
    450                 455                 460                 


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
465                 470                 475                 480 


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
                485                 490                 495     


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
            500                 505                 510         


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
        515                 520                 525             


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
    530                 535                 540     


<210>  158
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr 
305                 310                 315                 320 


Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr 
                325                 330                 335     


Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser 
            340                 345                 350         


Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly 
        355                 360                 365             


Thr Lys Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly 
385                 390                 395                 400 


Ala Glu Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala 
                405                 410                 415     


Ser Gly Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg 
            420                 425                 430         


Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly 
        435                 440                 445             


Arg Ile Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
465                 470                 475                 480 


Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr 
                485                 490                 495     


Thr Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
            500                 505                 510         


Ser Thr Lys 
        515 


<210>  159
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr Ser Phe Thr 
                245                 250                 255     


Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Ser Lys Gly Glu 
            260                 265                 270         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        275                 280                 285             


Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    290                 295                 300                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
305                 310                 315                 320 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
                325                 330                 335     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            340                 345                 350         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Tyr Lys 
        355                 360                 365             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    370                 375                 380                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
385                 390                 395                 400 


Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn Tyr Asn Ser His Asn 
                405                 410                 415     


Val Tyr Ile Met Ala Asp Lys Pro Lys Asn Gly Ile Lys Val Asn Phe 
            420                 425                 430         


Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val Gln Leu Ala Asp His 
        435                 440                 445             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    450                 455                 460                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
465                 470                 475                 480 


Lys Arg Asp His Met Ile Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                485                 490                 495     


Thr His Gly Met Asp Glu Leu Tyr Lys Asp Ile Gln Met Thr Gln Ser 
            500                 505                 510         


Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys 
        515                 520                 525             


Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala 
545                 550                 555                 560 


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr 
                565                 570                 575     


Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr 
            580                 585                 590         


Cys Gln His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        595                 600                 605             


Leu Glu Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
625                 630                 635                 640 


Leu Val Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly 
                645                 650                 655     


Tyr Ile Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly 
            660                 665                 670         


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile 
        675                 680                 685             


Asn Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
705                 710                 715                 720 


Ser Ala Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe 
                725                 730                 735     


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
            740                 745                 750         


Lys 
    


<210>  160
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Met 
            260                 265                 270         


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        275                 280                 285             


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    290                 295                 300                 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
305                 310                 315                 320 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
                325                 330                 335     


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
            340                 345                 350         


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        355                 360                 365             


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    370                 375                 380                 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                405                 410                 415     


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            420                 425                 430         


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        435                 440                 445             


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    450                 455                 460                 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
465                 470                 475                 480 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                485                 490                 495     


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly 
            500                 505                 510         


Leu Arg Ser Thr Gly Ser Arg Ser Phe Thr Lys Gln Ser Ile Ser Leu 
        515                 520                 525             


Ala Ser Leu Pro Lys Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys 
    530                 535                 540                 


Gly Thr Val Cys Leu Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe 
545                 550                 555                 560 


Trp Leu Ala Gly Leu Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala 
                565                 570                 575     


Leu Lys Ser Asp Tyr Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala 
            580                 585                 590         


Thr Ala Tyr Ile Leu Val Val Ala Gly Thr Val Val Met Val Thr Gly 
        595                 600                 605             


Val Leu Gly Cys Cys Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg 
    610                 615                 620                 


Leu Tyr Phe Ile Leu Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala 
625                 630                 635                 640 


Gly Ile Leu Ala Tyr Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys 
                645                 650                 655     


Glu Asn Leu Lys Asp Thr Met Thr Lys Arg Tyr His Gln Pro Gly His 
            660                 665                 670         


Glu Ala Val Thr Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys 
        675                 680                 685             


Cys Gly Ser Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg 
    690                 695                 700                 


Ser Gln Glu Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr 
705                 710                 715                 720 


Val Val Ala Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys 
                725                 730                 735     


Val Glu Gly Gly Cys Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His 
            740                 745                 750         


Leu Arg Val Ile Gly Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val 
        755                 760                 765             


Phe Gly Met Ile Phe Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu 
    770                 775                 780                 


His Tyr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
785                 790                 795                 800 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser 
                805                 810                 815     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
            820                 825                 830         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        835                 840                 845             


Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
    850                 855                 860                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
865                 870                 875                 880 


Glu Arg Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                885                 890                 895     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            900                 905                 910         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu 
        915                 920                 925             


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Pro Lys 
    930                 935                 940                 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly 
945                 950                 955                 960 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                965                 970                 975     


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
            980                 985                 990         


Leu Ser Lys Asp Pro Asn Glu Lys  Arg Asp His Met Ile  Leu Leu Glu 
        995                 1000                 1005             


Phe Val  Thr Ala Ala Gly Ile  Thr His Gly Met Asp  Glu Leu Tyr 
    1010                 1015                 1020             


Lys 
    


<210>  161
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
    50                  55                  60                  


Lys Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Gln Tyr Ser Leu 
                85                  90                  95      


Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
            100                 105                 110         


His Phe Trp Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Thr Val Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
145                 150                 155                 160 


Gln Pro Gly Thr Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ile 
                165                 170                 175     


Phe Thr Thr Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Asn Pro Asn Asn Gly Arg Ile Asn Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Val Gly Val Met Ile Thr Thr Phe Pro Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Ser 
            260                 265                 270         


Phe Thr Lys Gln Ser Ile Ser Leu Ala Ser Leu Pro Lys Met Gly Glu 
        275                 280                 285             


Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu Lys Tyr Leu 
    290                 295                 300                 


Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu Ala Val Met 
305                 310                 315                 320 


Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr Ile Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu Val Val Ala 
            340                 345                 350         


Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys Ala Thr Phe 
        355                 360                 365             


Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu Leu Leu Ile 
    370                 375                 380                 


Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr Ala Tyr Tyr 
385                 390                 395                 400 


Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp Thr Met Thr 
                405                 410                 415     


Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val Asp 
            420                 425                 430         


Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln Asp 
        435                 440                 445             


Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly Gly Arg Val 
    450                 455                 460                 


Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys Gly Gln Arg 
465                 470                 475                 480 


Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys Ile Thr Lys 
                485                 490                 495     


Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val Gly 
            500                 505                 510         


Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Thr Cys Cys 
        515                 520                 525             


Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
    530                 535             


