                         SEQUENCE LISTING

<110>  Cellresearch Corporation Pte. Ltd.
 
<120>  USE OF AN ESSENTIALLY PURE MESENCHYMAL STEM CELL POPULATION OF 
       THE AMNIOTIC MEMBRANE OF UMBILICAL CORD FOR GENERATING A 
       MAMMALIAN STEM CELL CARRYING A TRANSGENE

<130>  P1308-WO

<150>  US62/654,126
<151>  2018-04-06

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  2351
<212>  PRT
<213>  human

<400>  1

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  2
<211>  216
<212>  PRT
<213>  human

<400>  2

Met Arg Ile Gln Asp Pro Gly Lys Val Phe Phe Gly Asn Val Asp Ser 
1               5                   10                  15      


Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
            20                  25                  30          


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
        35                  40                  45              


Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met 
    50                  55                  60                  


Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu 
                85                  90                  95      


Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 
            100                 105                 110         


Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr 
        115                 120                 125             


Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe 
    130                 135                 140                 


Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln 
145                 150                 155                 160 


Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro 
                165                 170                 175     


Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile 
            180                 185                 190         


His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 
        195                 200                 205             


Gly Cys Glu Ala Gln Asp Leu Tyr 
    210                 215     


<210>  3
<211>  5213
<212>  PRT
<213>  artificial sequence

<220>
<223>  chimeric factor VIII polypeptide

<400>  3

Gly Thr Gly Thr Cys Gly Thr Gly Ala Ala Ala Ala Cys Thr Ala Cys 
1               5                   10                  15      


Cys Cys Cys Thr Ala Ala Ala Ala Gly Cys Cys Ala Cys Cys Gly Gly 
            20                  25                  30          


Cys Gly Thr Gly Gly Cys Thr Ala Gly Cys Ala Thr Gly Cys Ala Ala 
        35                  40                  45              


Ala Thr Ala Gly Ala Gly Cys Thr Cys Thr Cys Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Thr Thr Cys Thr Thr Thr Cys Thr Gly Thr Gly Cys Cys Thr 
65                  70                  75                  80  


Thr Thr Thr Gly Cys Gly Ala Thr Thr Cys Thr Gly Cys Thr Thr Thr 
                85                  90                  95      


Ala Gly Thr Gly Cys Cys Ala Thr Cys Ala Gly Gly Ala Gly Ala Thr 
            100                 105                 110         


Ala Cys Thr Ala Cys Cys Thr Gly Gly Gly Cys Gly Cys Ala Gly Thr 
        115                 120                 125             


Gly Gly Ala Ala Cys Thr Gly Thr Cys Cys Thr Gly Gly Gly Ala Cys 
    130                 135                 140                 


Thr Ala Cys Cys Gly Gly Cys Ala Ala Ala Gly Thr Gly Ala Ala Cys 
145                 150                 155                 160 


Thr Cys Cys Thr Cys Cys Gly Thr Gly Ala Gly Cys Thr Gly Cys Ala 
                165                 170                 175     


Cys Gly Thr Gly Gly Ala Cys Ala Cys Cys Ala Gly Ala Thr Thr Thr 
            180                 185                 190         


Cys Cys Thr Gly Cys Thr Ala Cys Ala Gly Cys Gly Cys Cys Ala Gly 
        195                 200                 205             


Gly Ala Gly Cys Thr Cys Thr Thr Cys Cys Gly Thr Thr Gly Gly Gly 
    210                 215                 220                 


Cys Cys Cys Gly Thr Cys Ala Gly Thr Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Gly Ala Cys Thr Gly Thr Gly Thr Thr Cys Gly 
                245                 250                 255     


Thr Ala Gly Ala Gly Thr Thr Cys Ala Cys Gly Gly Ala Thr Cys Ala 
            260                 265                 270         


Ala Cys Thr Thr Thr Thr Cys Ala Gly Cys Gly Thr Thr Gly Cys Cys 
        275                 280                 285             


Ala Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Ala Cys Cys Ala Thr 
    290                 295                 300                 


Gly Gly Ala Thr Gly Gly Gly Thr Cys Thr Gly Cys Thr Gly Gly Gly 
305                 310                 315                 320 


Thr Cys Cys Thr Ala Cys Cys Ala Thr Cys Cys Ala Gly Gly Cys Thr 
                325                 330                 335     


Gly Ala Gly Gly Thr Thr Thr Ala Cys Gly Ala Cys Ala Cys Gly Gly 
            340                 345                 350         


Thr Gly Gly Thr Cys Gly Thr Thr Ala Cys Cys Cys Thr Gly Ala Ala 
        355                 360                 365             


Gly Ala Ala Cys Ala Thr Gly Gly Cys Thr Thr Cys Thr Cys Ala Thr 
    370                 375                 380                 


Cys Cys Cys Gly Thr Thr Ala Gly Thr Cys Thr Thr Cys Ala Cys Gly 
385                 390                 395                 400 


Cys Thr Gly Thr Cys Gly Gly Cys Gly Thr Cys Thr Cys Cys Thr Thr 
                405                 410                 415     


Cys Thr Gly Gly Ala Ala Ala Thr Cys Thr Thr Cys Cys Gly Ala Ala 
            420                 425                 430         


Gly Gly Cys Gly Cys Thr Gly Ala Ala Thr Ala Thr Gly Ala Gly Gly 
        435                 440                 445             


Ala Thr Cys Ala Cys Ala Cys Cys Ala Gly Cys Cys Ala Ala Ala Gly 
    450                 455                 460                 


Gly Gly Ala Gly Ala Ala Gly Gly Ala Ala Gly Ala Cys Gly Ala Thr 
465                 470                 475                 480 


Ala Ala Ala Gly Thr Cys Cys Thr Thr Cys Cys Cys Gly Gly Thr Ala 
                485                 490                 495     


Ala Ala Ala Gly Cys Cys Ala Ala Ala Cys Cys Thr Ala Cys Gly Thr 
            500                 505                 510         


Cys Thr Gly Gly Cys Ala Gly Gly Thr Cys Cys Thr Gly Ala Ala Ala 
        515                 520                 525             


Gly Ala Ala Ala Ala Thr Gly Gly Thr Cys Cys Ala Ala Cys Ala Gly 
    530                 535                 540                 


Cys Cys Thr Cys Thr Gly Ala Cys Cys Cys Ala Cys Cys Ala Thr Gly 
545                 550                 555                 560 


Thr Cys Thr Cys Ala Cys Cys Thr Ala Cys Thr Cys Ala Thr Ala Cys 
                565                 570                 575     


Cys Thr Gly Thr Cys Thr Cys Ala Cys Gly Thr Gly Gly Ala Cys Cys 
            580                 585                 590         


Thr Gly Gly Thr Gly Ala Ala Ala Gly Ala Cys Cys Thr Gly Ala Ala 
        595                 600                 605             


Thr Thr Cys Gly Gly Gly Cys Cys Thr Cys Ala Thr Thr Gly Gly Ala 
    610                 615                 620                 


Gly Cys Cys Cys Thr Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Ala 
625                 630                 635                 640 


Gly Ala Gly Ala Ala Gly Gly Gly Ala Gly Thr Cys Thr Gly Ala Cys 
                645                 650                 655     


Cys Ala Gly Ala Gly Ala Ala Ala Gly Gly Ala Cys Cys Cys Ala Gly 
            660                 665                 670         


Ala Ala Cys Cys Thr Gly Cys Ala Cys Gly Ala Ala Thr Thr Thr Gly 
        675                 680                 685             


Thr Ala Cys Thr Ala Cys Thr Thr Thr Thr Thr Gly Cys Thr Gly Thr 
    690                 695                 700                 


Cys Thr Thr Thr Gly Ala Thr Gly Ala Ala Gly Gly Gly Ala Ala Ala 
705                 710                 715                 720 


Ala Gly Thr Thr Gly Gly Cys Ala Cys Thr Cys Ala Gly Cys Ala Ala 
                725                 730                 735     


Gly Ala Ala Ala Thr Gly Ala Cys Thr Cys Cys Thr Gly Gly Ala Cys 
            740                 745                 750         


Ala Cys Gly Gly Gly Cys Cys Ala Thr Gly Gly Ala Thr Cys Cys Cys 
        755                 760                 765             


Gly Cys Ala Cys Cys Thr Gly Cys Cys Ala Gly Gly Gly Cys Cys Cys 
    770                 775                 780                 


Ala Gly Cys Cys Thr Gly Cys Ala Ala Thr Gly Cys Ala Cys Ala Cys 
785                 790                 795                 800 


Ala Gly Thr Cys Ala Ala Thr Gly Gly Cys Thr Ala Thr Gly Thr Cys 
                805                 810                 815     


Ala Ala Cys Ala Gly Gly Thr Cys Thr Cys Thr Gly Cys Cys Ala Gly 
            820                 825                 830         


Gly Thr Cys Thr Gly Ala Thr Cys Gly Gly Ala Thr Gly Thr Cys Ala 
        835                 840                 845             


Thr Ala Ala Gly Ala Ala Ala Thr Cys Ala Gly Thr Cys Thr Ala Cys 
    850                 855                 860                 


Thr Gly Gly Cys Ala Cys Gly Thr Gly Ala Thr Thr Gly Gly Ala Ala 
865                 870                 875                 880 


Thr Gly Gly Gly Cys Ala Cys Cys Ala Gly Cys Cys Cys Gly Gly Ala 
                885                 890                 895     


Ala Gly Thr Gly Cys Ala Cys Thr Cys Cys Ala Thr Thr Thr Thr Thr 
            900                 905                 910         


Cys Thr Thr Gly Ala Ala Gly Gly Cys Cys Ala Cys Ala Cys Gly Thr 
        915                 920                 925             


Thr Thr Cys Thr Cys Gly Thr Gly Ala Gly Gly Cys Ala Cys Cys Ala 
    930                 935                 940                 


Thr Cys Gly Cys Cys Ala Gly Gly Cys Thr Thr Cys Cys Thr Thr Gly 
945                 950                 955                 960 


Gly Ala Gly Ala Thr Cys Thr Cys Gly Cys Cys Ala Cys Thr Ala Ala 
                965                 970                 975     


Cys Thr Thr Thr Cys Cys Thr Cys Ala Cys Thr Gly Cys Thr Cys Ala 
            980                 985                 990         


Gly Ala Cys Ala Thr Thr Cys Cys  Thr Gly Ala Thr Gly  Gly Ala Cys 
        995                 1000                 1005             


Cys Thr  Thr Gly Gly Cys Cys  Ala Gly Thr Thr Cys  Cys Thr Ala 
    1010                 1015                 1020             


Cys Thr  Gly Thr Thr Thr Thr  Gly Thr Cys Ala Thr  Ala Thr Cys 
    1025                 1030                 1035             


Thr Cys  Thr Thr Cys Cys Cys  Ala Cys Cys Ala Cys  Cys Ala Thr 
    1040                 1045                 1050             


Gly Gly  Thr Gly Gly Cys Ala  Thr Gly Gly Ala Gly  Gly Cys Thr 
    1055                 1060                 1065             


Cys Ala  Cys Gly Thr Cys Ala  Gly Ala Gly Thr Ala  Gly Ala Ala 
    1070                 1075                 1080             


Ala Gly  Cys Thr Gly Cys Gly  Cys Cys Gly Ala Gly  Gly Ala Gly 
    1085                 1090                 1095             


Cys Cys  Cys Cys Ala Gly Cys  Thr Gly Cys Gly Gly  Ala Gly Gly 
    1100                 1105                 1110             


Ala Ala  Ala Gly Cys Thr Gly  Ala Thr Gly Ala Ala  Gly Ala Gly 
    1115                 1120                 1125             


Gly Ala  Ala Gly Ala Thr Thr  Ala Thr Gly Ala Thr  Gly Ala Cys 
    1130                 1135                 1140             


Ala Ala  Thr Thr Thr Gly Thr  Ala Cys Gly Ala Cys  Thr Cys Gly 
    1145                 1150                 1155             


Gly Ala  Cys Ala Thr Gly Gly  Ala Cys Gly Thr Gly  Gly Thr Cys 
    1160                 1165                 1170             


Cys Gly  Gly Cys Thr Cys Gly  Ala Thr Gly Gly Thr  Gly Ala Cys 
    1175                 1180                 1185             


Gly Ala  Cys Gly Thr Gly Thr  Cys Thr Cys Cys Cys  Thr Thr Thr 
    1190                 1195                 1200             


Ala Thr  Cys Cys Ala Ala Ala  Thr Cys Cys Gly Cys  Thr Cys Ala 
    1205                 1210                 1215             


Gly Thr  Thr Gly Cys Cys Ala  Ala Gly Ala Ala Gly  Cys Ala Thr 
    1220                 1225                 1230             


Cys Cys  Thr Ala Ala Ala Ala  Cys Thr Thr Gly Gly  Gly Thr Ala 
    1235                 1240                 1245             


Cys Ala  Thr Thr Ala Cys Ala  Thr Thr Gly Cys Thr  Gly Cys Thr 
    1250                 1255                 1260             


Gly Ala  Ala Gly Ala Gly Gly  Ala Gly Gly Ala Cys  Thr Gly Gly 
    1265                 1270                 1275             


Gly Ala  Cys Thr Ala Thr Gly  Cys Thr Cys Cys Cys  Thr Thr Ala 
    1280                 1285                 1290             


Gly Thr  Cys Cys Thr Cys Gly  Cys Cys Cys Cys Cys  Gly Ala Thr 
    1295                 1300                 1305             


Gly Ala  Cys Ala Gly Ala Ala  Gly Thr Thr Ala Thr  Ala Ala Ala 
    1310                 1315                 1320             


Ala Gly  Thr Cys Ala Ala Thr  Ala Thr Thr Thr Gly  Ala Ala Cys 
    1325                 1330                 1335             


Ala Ala  Thr Gly Gly Cys Cys  Cys Thr Cys Ala Gly  Cys Gly Gly 
    1340                 1345                 1350             


Ala Thr  Thr Gly Gly Thr Ala  Gly Gly Ala Ala Gly  Thr Ala Cys 
    1355                 1360                 1365             


Ala Ala  Ala Ala Ala Ala Gly  Thr Cys Cys Gly Ala  Thr Thr Thr 
    1370                 1375                 1380             


Ala Thr  Gly Gly Cys Ala Thr  Ala Cys Ala Cys Ala  Gly Ala Thr 
    1385                 1390                 1395             


Gly Ala  Ala Ala Cys Cys Thr  Thr Thr Ala Ala Gly  Ala Cys Thr 
    1400                 1405                 1410             


Cys Gly  Thr Gly Ala Ala Gly  Cys Thr Ala Thr Thr  Cys Ala Gly 
    1415                 1420                 1425             


Cys Ala  Thr Gly Ala Ala Thr  Cys Ala Gly Gly Ala  Ala Thr Cys 
    1430                 1435                 1440             


Thr Thr  Gly Gly Gly Ala Cys  Cys Thr Thr Thr Ala  Cys Thr Thr 
    1445                 1450                 1455             


Thr Ala  Thr Gly Gly Gly Gly  Ala Ala Gly Thr Thr  Gly Gly Ala 
    1460                 1465                 1470             


Gly Ala  Cys Ala Cys Ala Cys  Thr Gly Thr Thr Gly  Ala Thr Thr 
    1475                 1480                 1485             


Ala Thr  Ala Thr Thr Thr Ala  Ala Gly Ala Ala Thr  Cys Ala Ala 
    1490                 1495                 1500             


Gly Cys  Ala Ala Gly Cys Ala  Gly Ala Cys Cys Ala  Thr Ala Thr 
    1505                 1510                 1515             


Ala Ala  Cys Ala Thr Cys Thr  Ala Cys Cys Cys Thr  Cys Ala Cys 
    1520                 1525                 1530             


Gly Gly  Ala Ala Thr Cys Ala  Cys Thr Gly Ala Thr  Gly Thr Cys 
    1535                 1540                 1545             


Cys Gly  Thr Cys Cys Thr Thr  Thr Gly Thr Ala Thr  Thr Cys Ala 
    1550                 1555                 1560             


Ala Gly  Gly Ala Gly Ala Thr  Thr Ala Cys Cys Ala  Ala Ala Ala 
    1565                 1570                 1575             


Gly Gly  Thr Gly Thr Ala Ala  Ala Ala Cys Ala Thr  Thr Thr Gly 
    1580                 1585                 1590             


Ala Ala  Gly Gly Ala Thr Thr  Thr Thr Cys Cys Ala  Ala Thr Thr 
    1595                 1600                 1605             


Cys Thr  Gly Cys Cys Ala Gly  Gly Ala Gly Ala Ala  Ala Thr Ala 
    1610                 1615                 1620             


Thr Thr  Cys Ala Ala Ala Thr  Ala Thr Ala Ala Ala  Thr Gly Gly 
    1625                 1630                 1635             


Ala Cys  Ala Gly Thr Gly Ala  Cys Thr Gly Thr Ala  Gly Ala Ala 
    1640                 1645                 1650             


Gly Ala  Thr Gly Gly Gly Cys  Cys Ala Ala Cys Thr  Ala Ala Ala 
    1655                 1660                 1665             


Thr Cys  Ala Gly Ala Thr Cys  Cys Thr Cys Gly Gly  Thr Gly Cys 
    1670                 1675                 1680             


Cys Thr  Gly Ala Cys Cys Cys  Gly Cys Thr Ala Thr  Thr Ala Cys 
    1685                 1690                 1695             


Thr Cys  Thr Ala Gly Thr Thr  Thr Cys Gly Thr Thr  Ala Ala Thr 
    1700                 1705                 1710             


Ala Thr  Gly Gly Ala Gly Ala  Gly Ala Gly Ala Thr  Cys Thr Ala 
    1715                 1720                 1725             


Gly Cys  Thr Thr Cys Ala Gly  Gly Ala Cys Thr Cys  Ala Thr Thr 
    1730                 1735                 1740             


Gly Gly  Cys Cys Cys Thr Cys  Thr Cys Cys Thr Cys  Ala Thr Cys 
    1745                 1750                 1755             


Thr Gly  Cys Thr Ala Cys Ala  Ala Ala Gly Ala Ala  Thr Cys Thr 
    1760                 1765                 1770             


Gly Thr  Ala Gly Ala Thr Cys  Ala Ala Ala Gly Ala  Gly Gly Ala 
    1775                 1780                 1785             


Ala Ala  Cys Cys Ala Gly Ala  Thr Ala Ala Thr Gly  Thr Cys Ala 
    1790                 1795                 1800             


Gly Ala  Cys Ala Ala Gly Ala  Gly Gly Ala Ala Thr  Gly Thr Cys 
    1805                 1810                 1815             


Ala Thr  Cys Cys Thr Gly Thr  Thr Thr Thr Cys Thr  Gly Thr Ala 
    1820                 1825                 1830             


Thr Thr  Thr Gly Ala Thr Gly  Ala Gly Ala Ala Cys  Cys Gly Ala 
    1835                 1840                 1845             


Ala Gly  Cys Thr Gly Gly Thr  Ala Cys Cys Thr Cys  Ala Cys Ala 
    1850                 1855                 1860             


Gly Ala  Gly Ala Ala Thr Ala  Thr Ala Cys Ala Ala  Cys Gly Cys 
    1865                 1870                 1875             


Thr Thr  Thr Cys Thr Cys Cys  Cys Cys Ala Ala Thr  Cys Cys Ala 
    1880                 1885                 1890             


Gly Cys  Thr Gly Gly Ala Gly  Thr Gly Cys Ala Gly  Cys Thr Thr 
    1895                 1900                 1905             


Gly Ala  Gly Gly Ala Thr Cys  Cys Ala Gly Ala Gly  Thr Thr Cys 
    1910                 1915                 1920             


Cys Ala  Ala Gly Cys Cys Thr  Cys Cys Ala Ala Cys  Ala Thr Cys 
    1925                 1930                 1935             


Ala Thr  Gly Cys Ala Cys Ala  Gly Cys Ala Thr Cys  Ala Ala Thr 
    1940                 1945                 1950             


Gly Gly  Cys Thr Ala Thr Gly  Thr Thr Thr Thr Thr  Gly Ala Thr 
    1955                 1960                 1965             


Ala Gly  Thr Thr Thr Gly Cys  Ala Gly Thr Thr Gly  Thr Cys Ala 
    1970                 1975                 1980             


Gly Thr  Thr Thr Gly Thr Thr  Thr Gly Cys Ala Thr  Gly Ala Gly 
    1985                 1990                 1995             


Gly Thr  Gly Gly Cys Ala Thr  Ala Cys Thr Gly Gly  Thr Ala Cys 
    2000                 2005                 2010             


Ala Thr  Thr Cys Thr Ala Ala  Gly Cys Ala Thr Thr  Gly Gly Ala 
    2015                 2020                 2025             


Gly Cys  Ala Cys Ala Gly Ala  Cys Thr Gly Ala Cys  Thr Thr Cys 
    2030                 2035                 2040             


Cys Thr  Thr Thr Cys Thr Gly  Thr Cys Thr Thr Cys  Thr Thr Cys 
    2045                 2050                 2055             


Thr Cys  Thr Gly Gly Ala Thr  Ala Thr Ala Cys Cys  Thr Thr Cys 
    2060                 2065                 2070             


Ala Ala  Ala Cys Ala Cys Ala  Ala Ala Ala Thr Gly  Gly Thr Cys 
    2075                 2080                 2085             


Thr Ala  Thr Gly Ala Ala Gly  Ala Cys Ala Cys Ala  Cys Thr Cys 
    2090                 2095                 2100             


Ala Cys  Cys Cys Thr Ala Thr  Thr Cys Cys Cys Ala  Thr Thr Cys 
    2105                 2110                 2115             


Thr Cys  Ala Gly Gly Ala Gly  Ala Ala Ala Cys Thr  Gly Thr Cys 
    2120                 2125                 2130             


Thr Thr  Cys Ala Thr Gly Thr  Cys Gly Ala Thr Gly  Gly Ala Ala 
    2135                 2140                 2145             


Ala Ala  Cys Cys Cys Ala Gly  Gly Thr Cys Thr Ala  Thr Gly Gly 
    2150                 2155                 2160             


Ala Thr  Thr Cys Thr Gly Gly  Gly Gly Thr Gly Cys  Cys Ala Cys 
    2165                 2170                 2175             


Ala Ala  Cys Thr Cys Ala Gly  Ala Cys Thr Thr Thr  Cys Gly Gly 
    2180                 2185                 2190             


Ala Ala  Cys Ala Gly Ala Gly  Gly Cys Ala Thr Gly  Ala Cys Cys 
    2195                 2200                 2205             


Gly Cys  Cys Thr Thr Ala Cys  Thr Gly Ala Ala Gly  Gly Thr Thr 
    2210                 2215                 2220             


Thr Cys  Thr Ala Gly Thr Thr  Gly Thr Gly Ala Cys  Ala Ala Gly 
    2225                 2230                 2235             


Ala Ala  Cys Ala Cys Thr Gly  Gly Thr Gly Ala Thr  Thr Ala Thr 
    2240                 2245                 2250             


Thr Ala  Cys Gly Ala Gly Gly  Ala Cys Ala Gly Thr  Thr Ala Thr 
    2255                 2260                 2265             


Gly Ala  Ala Gly Ala Thr Ala  Thr Thr Thr Cys Ala  Gly Cys Ala 
    2270                 2275                 2280             


Thr Ala  Cys Thr Thr Gly Cys  Thr Gly Ala Gly Thr  Ala Ala Ala 
    2285                 2290                 2295             


Ala Ala  Cys Ala Ala Thr Gly  Cys Cys Ala Thr Thr  Gly Ala Ala 
    2300                 2305                 2310             


Cys Cys  Ala Ala Gly Ala Ala  Gly Cys Thr Thr Cys  Thr Cys Cys 
    2315                 2320                 2325             


Cys Ala  Gly Ala Ala Thr Thr  Cys Ala Ala Gly Ala  Cys Ala Cys 
    2330                 2335                 2340             


Cys Cys  Thr Ala Gly Cys Ala  Cys Thr Ala Gly Gly  Cys Ala Ala 
    2345                 2350                 2355             


Ala Ala  Gly Cys Ala Ala Thr  Thr Thr Ala Ala Thr  Gly Cys Cys 
    2360                 2365                 2370             


Ala Cys  Cys Ala Cys Ala Ala  Thr Thr Cys Cys Ala  Gly Ala Ala 
    2375                 2380                 2385             


Ala Ala  Thr Gly Ala Cys Ala  Thr Ala Gly Ala Gly  Ala Ala Gly 
    2390                 2395                 2400             


Ala Cys  Thr Gly Ala Cys Cys  Cys Thr Thr Gly Gly  Thr Thr Thr 
    2405                 2410                 2415             


Gly Cys  Ala Cys Ala Cys Ala  Gly Ala Ala Cys Ala  Cys Cys Thr 
    2420                 2425                 2430             


Ala Thr  Gly Cys Cys Thr Ala  Ala Ala Ala Thr Ala  Cys Ala Ala 
    2435                 2440                 2445             


Ala Ala  Thr Gly Thr Cys Thr  Cys Cys Thr Cys Thr  Ala Gly Thr 
    2450                 2455                 2460             


Gly Ala  Thr Thr Thr Gly Thr  Thr Gly Ala Thr Gly  Cys Thr Cys 
    2465                 2470                 2475             


Thr Thr  Gly Cys Gly Ala Cys  Ala Gly Ala Gly Thr  Cys Cys Thr 
    2480                 2485                 2490             


Ala Cys  Thr Cys Cys Ala Cys  Ala Thr Gly Gly Gly  Cys Thr Ala 
    2495                 2500                 2505             


Thr Cys  Cys Thr Thr Ala Thr  Cys Thr Gly Ala Thr  Cys Thr Cys 
    2510                 2515                 2520             


Cys Ala  Ala Gly Ala Ala Gly  Cys Cys Ala Ala Ala  Thr Ala Thr 
    2525                 2530                 2535             


Gly Ala  Gly Ala Cys Thr Thr  Thr Thr Thr Cys Thr  Gly Ala Thr 
    2540                 2545                 2550             


Gly Ala  Thr Cys Cys Ala Thr  Cys Ala Cys Cys Thr  Gly Gly Ala 
    2555                 2560                 2565             


Gly Cys  Ala Ala Thr Ala Gly  Ala Cys Ala Gly Thr  Ala Ala Thr 
    2570                 2575                 2580             


Ala Ala  Cys Ala Gly Cys Cys  Thr Gly Thr Cys Thr  Gly Ala Ala 
    2585                 2590                 2595             


Ala Thr  Gly Ala Cys Ala Cys  Ala Cys Thr Thr Cys  Ala Gly Gly 
    2600                 2605                 2610             


Cys Cys  Ala Cys Ala Gly Cys  Thr Cys Cys Ala Thr  Cys Ala Cys 
    2615                 2620                 2625             


Ala Gly  Thr Gly Gly Gly Gly  Ala Cys Ala Thr Gly  Gly Thr Ala 
    2630                 2635                 2640             


Thr Thr  Thr Ala Cys Cys Cys  Cys Thr Gly Ala Gly  Thr Cys Ala 
    2645                 2650                 2655             


Gly Gly  Cys Cys Thr Cys Cys  Ala Ala Thr Thr Ala  Ala Gly Ala 
    2660                 2665                 2670             


Thr Thr  Ala Ala Ala Thr Gly  Ala Gly Ala Ala Ala  Cys Thr Gly 
    2675                 2680                 2685             


Gly Gly  Gly Ala Cys Ala Ala  Cys Thr Gly Cys Ala  Gly Cys Ala 
    2690                 2695                 2700             


Ala Cys  Ala Gly Ala Gly Thr  Thr Gly Ala Ala Gly  Ala Ala Ala 
    2705                 2710                 2715             


Cys Thr  Thr Gly Ala Thr Thr  Thr Cys Ala Ala Ala  Gly Thr Thr 
    2720                 2725                 2730             


Thr Cys  Thr Ala Gly Thr Ala  Cys Ala Thr Cys Ala  Ala Ala Thr 
    2735                 2740                 2745             


Ala Ala  Thr Cys Thr Gly Ala  Thr Thr Thr Cys Ala  Ala Cys Ala 
    2750                 2755                 2760             


Ala Thr  Thr Cys Cys Ala Thr  Cys Ala Gly Ala Cys  Ala Ala Thr 
    2765                 2770                 2775             


Thr Thr  Gly Gly Cys Ala Gly  Cys Ala Gly Gly Thr  Ala Cys Thr 
    2780                 2785                 2790             


Gly Ala  Thr Ala Ala Thr Ala  Cys Ala Ala Gly Thr  Thr Cys Cys 
    2795                 2800                 2805             


Thr Thr  Ala Gly Gly Ala Cys  Cys Cys Cys Cys Ala  Ala Gly Thr 
    2810                 2815                 2820             


Ala Thr  Gly Cys Cys Ala Gly  Thr Thr Cys Ala Thr  Thr Ala Thr 
    2825                 2830                 2835             


Gly Ala  Thr Ala Gly Thr Cys  Ala Ala Thr Thr Ala  Gly Ala Thr 
    2840                 2845                 2850             


Ala Cys  Cys Ala Cys Thr Cys  Thr Ala Thr Thr Thr  Gly Gly Cys 
    2855                 2860                 2865             


Ala Ala  Ala Ala Ala Gly Thr  Cys Ala Thr Cys Thr  Cys Cys Cys 
    2870                 2875                 2880             


Cys Thr  Thr Ala Cys Thr Gly  Ala Gly Thr Cys Thr  Gly Gly Thr 
    2885                 2890                 2895             


Gly Gly  Ala Cys Cys Thr Cys  Thr Gly Ala Gly Cys  Thr Thr Gly 
    2900                 2905                 2910             


Ala Gly  Thr Gly Ala Ala Gly  Ala Ala Ala Ala Thr  Ala Ala Thr 
    2915                 2920                 2925             


Gly Ala  Thr Thr Cys Ala Ala  Ala Gly Thr Thr Gly  Thr Thr Ala 
    2930                 2935                 2940             


Gly Ala  Ala Thr Cys Ala Gly  Gly Thr Thr Thr Ala  Ala Thr Gly 
    2945                 2950                 2955             


Ala Ala  Thr Ala Gly Cys Cys  Ala Ala Gly Ala Ala  Ala Gly Thr 
    2960                 2965                 2970             


Thr Cys  Ala Thr Gly Gly Gly  Gly Ala Ala Ala Ala  Ala Ala Thr 
    2975                 2980                 2985             


Gly Thr  Ala Thr Cys Gly Thr  Cys Ala Ala Cys Ala  Gly Ala Gly 
    2990                 2995                 3000             


Ala Gly  Thr Gly Gly Thr Ala  Gly Gly Thr Thr Ala  Thr Thr Thr 
    3005                 3010                 3015             


Ala Ala  Ala Gly Gly Gly Ala  Ala Ala Ala Gly Ala  Gly Cys Thr 
    3020                 3025                 3030             


Cys Ala  Thr Gly Gly Ala Cys  Cys Thr Gly Cys Thr  Thr Thr Gly 
    3035                 3040                 3045             


Thr Thr  Gly Ala Cys Thr Ala  Ala Ala Gly Ala Thr  Gly Gly Gly 
    3050                 3055                 3060             


Ala Gly  Gly Ala Cys Thr Gly  Ala Ala Ala Gly Gly  Cys Thr Gly 
    3065                 3070                 3075             


Thr Gly  Cys Thr Cys Thr Cys  Ala Ala Ala Ala Cys  Cys Cys Ala 
    3080                 3085                 3090             


Cys Cys  Ala Gly Thr Cys Thr  Thr Gly Ala Ala Ala  Cys Gly Cys 
    3095                 3100                 3105             


Cys Ala  Thr Cys Ala Ala Cys  Gly Gly Gly Ala Ala  Ala Thr Ala 
    3110                 3115                 3120             


Ala Cys  Thr Cys Gly Thr Ala  Cys Thr Ala Cys Thr  Cys Thr Thr 
    3125                 3130                 3135             


Cys Ala  Gly Thr Cys Ala Gly  Ala Thr Cys Ala Ala  Gly Ala Gly 
    3140                 3145                 3150             


Gly Ala  Ala Ala Thr Thr Gly  Ala Cys Thr Ala Thr  Gly Ala Thr 
    3155                 3160                 3165             


Gly Ala  Thr Ala Cys Cys Ala  Thr Ala Thr Cys Ala  Gly Thr Thr 
    3170                 3175                 3180             


Gly Ala  Ala Ala Thr Gly Ala  Ala Gly Ala Ala Gly  Gly Ala Ala 
    3185                 3190                 3195             


Gly Ala  Thr Thr Thr Thr Gly  Ala Cys Ala Thr Thr  Thr Ala Thr 
    3200                 3205                 3210             


Gly Ala  Thr Gly Ala Gly Gly  Ala Thr Gly Ala Ala  Ala Ala Thr 
    3215                 3220                 3225             


Cys Ala  Gly Ala Gly Cys Cys  Cys Cys Cys Gly Cys  Ala Gly Cys 
    3230                 3235                 3240             


Thr Thr  Thr Cys Ala Gly Ala  Ala Gly Ala Gly Ala  Ala Cys Cys 
    3245                 3250                 3255             


Cys Gly  Ala Cys Ala Cys Thr  Ala Thr Thr Thr Cys  Ala Thr Thr 
    3260                 3265                 3270             


Gly Cys  Thr Gly Cys Gly Gly  Thr Gly Gly Ala Gly  Cys Ala Gly 
    3275                 3280                 3285             


Cys Thr  Cys Thr Gly Gly Gly  Ala Thr Thr Ala Cys  Gly Gly Gly 
    3290                 3295                 3300             


Ala Thr  Gly Ala Gly Cys Gly  Ala Ala Thr Cys Cys  Cys Cys Cys 
    3305                 3310                 3315             


Cys Gly  Gly Gly Cys Gly Cys  Thr Ala Ala Gly Ala  Ala Ala Cys 
    3320                 3325                 3330             


Ala Gly  Gly Gly Cys Thr Cys  Ala Gly Ala Ala Cys  Gly Gly Ala 
    3335                 3340                 3345             


Gly Ala  Gly Gly Thr Gly Cys  Cys Thr Cys Gly Gly  Thr Thr Cys 
    3350                 3355                 3360             


Ala Ala  Gly Ala Ala Gly Gly  Thr Gly Gly Thr Cys  Thr Thr Cys 
    3365                 3370                 3375             


Cys Gly  Gly Gly Ala Ala Thr  Thr Thr Gly Cys Thr  Gly Ala Cys 
    3380                 3385                 3390             


Gly Gly  Cys Thr Cys Cys Thr  Thr Cys Ala Cys Gly  Cys Ala Gly 
    3395                 3400                 3405             


Cys Cys  Gly Thr Cys Gly Thr  Ala Cys Cys Gly Cys  Gly Gly Gly 
    3410                 3415                 3420             


Gly Ala  Ala Cys Thr Cys Ala  Ala Cys Ala Ala Ala  Cys Ala Cys 
    3425                 3430                 3435             


Thr Thr  Gly Gly Gly Gly Cys  Thr Cys Thr Thr Gly  Gly Gly Ala 
    3440                 3445                 3450             


Cys Cys  Cys Thr Ala Cys Ala  Thr Cys Ala Gly Ala  Gly Cys Gly 
    3455                 3460                 3465             


Gly Ala  Ala Gly Thr Thr Gly  Ala Ala Gly Ala Cys  Ala Ala Cys 
    3470                 3475                 3480             


Ala Thr  Cys Ala Thr Gly Gly  Thr Ala Ala Cys Thr  Thr Thr Cys 
    3485                 3490                 3495             


Ala Ala  Ala Ala Ala Cys Cys  Ala Gly Gly Cys Gly  Thr Cys Thr 
    3500                 3505                 3510             


Cys Gly  Thr Cys Cys Cys Thr  Ala Thr Thr Cys Cys  Thr Thr Cys 
    3515                 3520                 3525             


Thr Ala  Cys Thr Cys Gly Ala  Gly Cys Cys Thr Thr  Ala Thr Thr 
    3530                 3535                 3540             


Thr Cys  Thr Thr Ala Thr Cys  Cys Gly Gly Ala Thr  Gly Ala Thr 
    3545                 3550                 3555             


Cys Ala  Gly Gly Ala Gly Cys  Ala Ala Gly Gly Gly  Gly Cys Ala 
    3560                 3565                 3570             


Gly Ala  Ala Cys Cys Thr Cys  Gly Ala Cys Ala Cys  Ala Ala Cys 
    3575                 3580                 3585             


Thr Thr  Cys Gly Thr Cys Cys  Ala Gly Cys Cys Ala  Ala Ala Thr 
    3590                 3595                 3600             


Gly Ala  Ala Ala Cys Cys Ala  Gly Ala Ala Cys Thr  Thr Ala Cys 
    3605                 3610                 3615             


Thr Thr  Thr Thr Gly Gly Ala  Ala Ala Gly Thr Gly  Cys Ala Gly 
    3620                 3625                 3630             


Cys Ala  Thr Cys Ala Cys Ala  Thr Gly Gly Cys Ala  Cys Cys Cys 
    3635                 3640                 3645             


Ala Cys  Ala Gly Ala Ala Gly  Ala Cys Gly Ala Gly  Thr Thr Thr 
    3650                 3655                 3660             


Gly Ala  Cys Thr Gly Cys Ala  Ala Ala Gly Cys Cys  Thr Gly Gly 
    3665                 3670                 3675             


Gly Cys  Cys Thr Ala Cys Thr  Thr Thr Thr Cys Thr  Gly Ala Thr 
    3680                 3685                 3690             


Gly Thr  Thr Gly Ala Cys Cys  Thr Gly Gly Ala Ala  Ala Ala Ala 
    3695                 3700                 3705             


Gly Ala  Thr Gly Thr Gly Cys  Ala Cys Thr Cys Ala  Gly Gly Cys 
    3710                 3715                 3720             


Thr Thr  Gly Ala Thr Cys Gly  Gly Cys Cys Cys Cys  Cys Thr Thr 
    3725                 3730                 3735             


Cys Thr  Gly Ala Thr Cys Thr  Gly Cys Cys Gly Cys  Gly Cys Cys 
    3740                 3745                 3750             


Ala Ala  Cys Ala Cys Cys Cys  Thr Gly Ala Ala Cys  Gly Cys Thr 
    3755                 3760                 3765             


Gly Cys  Thr Cys Ala Cys Gly  Gly Thr Ala Gly Ala  Cys Ala Ala 
    3770                 3775                 3780             


Gly Thr  Gly Ala Cys Cys Gly  Thr Gly Cys Ala Ala  Gly Ala Ala 
    3785                 3790                 3795             


Thr Thr  Thr Gly Cys Thr Cys  Thr Gly Thr Thr Thr  Thr Thr Cys 
    3800                 3805                 3810             


Ala Cys  Thr Ala Thr Thr Thr  Thr Thr Gly Ala Thr  Gly Ala Gly 
    3815                 3820                 3825             


Ala Cys  Ala Ala Ala Gly Ala  Gly Cys Thr Gly Gly  Thr Ala Cys 
    3830                 3835                 3840             


Thr Thr  Cys Ala Cys Thr Gly  Ala Ala Ala Ala Thr  Gly Thr Gly 
    3845                 3850                 3855             


Gly Ala  Ala Ala Gly Gly Ala  Ala Cys Thr Gly Cys  Cys Gly Gly 
    3860                 3865                 3870             


Gly Cys  Cys Cys Cys Cys Thr  Gly Cys Cys Ala Cys  Cys Thr Gly 
    3875                 3880                 3885             


Cys Ala  Gly Ala Thr Gly Gly  Ala Gly Gly Ala Cys  Cys Cys Cys 
    3890                 3895                 3900             


Ala Cys  Thr Cys Thr Gly Ala  Ala Ala Gly Ala Ala  Ala Ala Cys 
    3905                 3910                 3915             


Thr Ala  Thr Cys Gly Cys Thr  Thr Cys Cys Ala Thr  Gly Cys Ala 
    3920                 3925                 3930             


Ala Thr  Cys Ala Ala Thr Gly  Gly Cys Thr Ala Thr  Gly Thr Gly 
    3935                 3940                 3945             


Ala Thr  Gly Gly Ala Thr Ala  Cys Ala Cys Thr Cys  Cys Cys Thr 
    3950                 3955                 3960             


Gly Gly  Cys Thr Thr Ala Gly  Thr Ala Ala Thr Gly  Gly Cys Thr 
    3965                 3970                 3975             


Cys Ala  Gly Ala Ala Thr Cys  Ala Ala Ala Gly Gly  Ala Thr Cys 
    3980                 3985                 3990             


Cys Gly  Ala Thr Gly Gly Thr  Ala Thr Cys Thr Gly  Cys Thr Cys 
    3995                 4000                 4005             


Ala Gly  Cys Ala Thr Gly Gly  Gly Cys Ala Gly Cys  Ala Ala Thr 
    4010                 4015                 4020             


Gly Ala  Ala Ala Ala Thr Ala  Thr Cys Cys Ala Thr  Thr Cys Gly 
    4025                 4030                 4035             


Ala Thr  Thr Cys Ala Thr Thr  Thr Thr Ala Gly Cys  Gly Gly Ala 
    4040                 4045                 4050             


Cys Ala  Cys Gly Thr Gly Thr  Thr Cys Ala Gly Thr  Gly Thr Ala 
    4055                 4060                 4065             


Cys Gly  Gly Ala Ala Ala Ala  Ala Gly Gly Ala Gly  Gly Ala Gly 
    4070                 4075                 4080             


Thr Ala  Thr Ala Ala Ala Ala  Thr Gly Gly Cys Cys  Gly Thr Gly 
    4085                 4090                 4095             


Thr Ala  Cys Ala Ala Thr Cys  Thr Cys Thr Ala Thr  Cys Cys Gly 
    4100                 4105                 4110             


Gly Gly  Thr Gly Thr Cys Thr  Thr Thr Gly Ala Gly  Ala Cys Ala 
    4115                 4120                 4125             


Gly Thr  Gly Gly Ala Ala Ala  Thr Gly Cys Thr Ala  Cys Cys Gly 
    4130                 4135                 4140             


Thr Cys  Cys Ala Ala Ala Gly  Thr Thr Gly Gly Ala  Ala Thr Thr 
    4145                 4150                 4155             


Thr Gly  Gly Cys Gly Ala Ala  Thr Ala Gly Ala Ala  Thr Gly Cys 
    4160                 4165                 4170             


Cys Thr  Gly Ala Thr Thr Gly  Gly Cys Gly Ala Gly  Cys Ala Cys 
    4175                 4180                 4185             


Cys Thr  Gly Cys Ala Ala Gly  Cys Thr Gly Gly Gly  Ala Thr Gly 
    4190                 4195                 4200             


Ala Gly  Cys Ala Cys Gly Ala  Cys Thr Thr Thr Cys  Cys Thr Gly 
    4205                 4210                 4215             


Gly Thr  Gly Thr Ala Cys Ala  Gly Cys Ala Ala Gly  Ala Ala Gly 
    4220                 4225                 4230             


Thr Gly  Thr Cys Ala Gly Ala  Cys Thr Cys Cys Cys  Cys Thr Gly 
    4235                 4240                 4245             


Gly Gly  Ala Ala Thr Gly Gly  Cys Thr Thr Cys Thr  Gly Gly Ala 
    4250                 4255                 4260             


Cys Ala  Cys Ala Thr Thr Ala  Gly Ala Gly Ala Thr  Thr Thr Thr 
    4265                 4270                 4275             


Cys Ala  Gly Ala Thr Thr Ala  Cys Ala Gly Cys Thr  Thr Cys Ala 
    4280                 4285                 4290             


Gly Gly  Ala Cys Ala Ala Thr  Ala Thr Gly Gly Ala  Cys Ala Gly 
    4295                 4300                 4305             


Thr Gly  Gly Gly Cys Cys Cys  Cys Ala Ala Ala Gly  Cys Thr Gly 
    4310                 4315                 4320             


Gly Cys  Cys Ala Gly Ala Cys  Thr Thr Cys Ala Thr  Thr Ala Thr 
    4325                 4330                 4335             


Thr Cys  Cys Gly Gly Ala Thr  Cys Ala Ala Thr Cys  Ala Ala Thr 
    4340                 4345                 4350             


Gly Cys  Cys Thr Gly Gly Ala  Gly Cys Ala Cys Cys  Ala Ala Gly 
    4355                 4360                 4365             


Gly Ala  Gly Cys Cys Cys Thr  Thr Thr Thr Cys Thr  Thr Gly Gly 
    4370                 4375                 4380             


Ala Thr  Cys Ala Ala Gly Gly  Thr Gly Gly Ala Thr  Cys Thr Gly 
    4385                 4390                 4395             


Thr Thr  Gly Gly Cys Ala Cys  Cys Ala Ala Thr Gly  Ala Thr Thr 
    4400                 4405                 4410             


Ala Thr  Thr Cys Ala Cys Gly  Gly Cys Ala Thr Cys  Ala Ala Gly 
    4415                 4420                 4425             


Ala Cys  Cys Cys Ala Gly Gly  Gly Thr Gly Cys Cys  Cys Gly Thr 
    4430                 4435                 4440             


Cys Ala  Gly Ala Ala Gly Thr  Thr Cys Thr Cys Cys  Ala Gly Cys 
    4445                 4450                 4455             


Cys Thr  Cys Thr Ala Cys Ala  Thr Cys Thr Cys Thr  Cys Ala Gly 
    4460                 4465                 4470             


Thr Thr  Thr Ala Thr Cys Ala  Thr Cys Ala Thr Gly  Thr Ala Thr 
    4475                 4480                 4485             


Ala Gly  Thr Cys Thr Thr Gly  Ala Thr Gly Gly Gly  Ala Ala Gly 
    4490                 4495                 4500             


Ala Ala  Gly Thr Gly Gly Cys  Ala Gly Ala Cys Thr  Thr Ala Thr 
    4505                 4510                 4515             


Cys Gly  Ala Gly Gly Ala Ala  Ala Thr Thr Cys Cys  Ala Cys Thr 
    4520                 4525                 4530             


Gly Gly  Ala Ala Cys Cys Thr  Thr Ala Ala Thr Gly  Gly Thr Cys 
    4535                 4540                 4545             


Thr Thr  Cys Thr Thr Thr Gly  Gly Cys Ala Ala Thr  Gly Thr Gly 
    4550                 4555                 4560             


Gly Ala  Thr Thr Cys Ala Thr  Cys Thr Gly Gly Gly  Ala Thr Ala 
    4565                 4570                 4575             


Ala Ala  Ala Cys Ala Cys Ala  Ala Thr Ala Thr Thr  Thr Thr Thr 
    4580                 4585                 4590             


Ala Ala  Cys Cys Cys Thr Cys  Cys Ala Ala Thr Thr  Ala Thr Thr 
    4595                 4600                 4605             


Gly Cys  Thr Cys Gly Ala Thr  Ala Cys Ala Thr Cys  Cys Gly Thr 
    4610                 4615                 4620             


Thr Thr  Gly Cys Ala Cys Cys  Cys Ala Ala Cys Thr  Cys Ala Thr 
    4625                 4630                 4635             


Thr Ala  Thr Ala Gly Cys Ala  Thr Thr Cys Gly Cys  Ala Gly Cys 
    4640                 4645                 4650             


Ala Cys  Thr Cys Thr Thr Cys  Gly Cys Ala Thr Gly  Gly Ala Gly 
    4655                 4660                 4665             


Thr Thr  Gly Ala Thr Gly Gly  Gly Cys Thr Gly Thr  Gly Ala Thr 
    4670                 4675                 4680             


Thr Thr  Ala Ala Ala Thr Ala  Gly Thr Thr Gly Cys  Ala Gly Cys 
    4685                 4690                 4695             


Ala Thr  Gly Cys Cys Ala Thr  Thr Gly Gly Gly Ala  Ala Thr Gly 
    4700                 4705                 4710             


Gly Ala  Gly Ala Gly Thr Ala  Ala Ala Gly Cys Ala  Ala Thr Ala 
    4715                 4720                 4725             


Thr Cys  Ala Gly Ala Thr Gly  Cys Ala Cys Ala Gly  Ala Thr Thr 
    4730                 4735                 4740             


Ala Cys  Thr Gly Cys Thr Thr  Cys Ala Thr Cys Cys  Thr Ala Cys 
    4745                 4750                 4755             


Thr Thr  Thr Ala Cys Cys Ala  Ala Thr Ala Thr Gly  Thr Thr Thr 
    4760                 4765                 4770             


Gly Cys  Cys Ala Cys Cys Thr  Gly Gly Thr Cys Thr  Cys Cys Thr 
    4775                 4780                 4785             


Thr Cys  Ala Ala Ala Ala Gly  Cys Thr Cys Gly Ala  Cys Thr Thr 
    4790                 4795                 4800             


Cys Ala  Cys Cys Thr Cys Cys  Ala Ala Gly Gly Gly  Ala Gly Gly 
    4805                 4810                 4815             


Ala Gly  Thr Ala Ala Thr Gly  Cys Cys Thr Gly Gly  Ala Gly Ala 
    4820                 4825                 4830             


Cys Cys  Thr Cys Ala Gly Gly  Thr Gly Ala Ala Thr  Ala Ala Thr 
    4835                 4840                 4845             


Cys Cys  Ala Ala Ala Ala Gly  Ala Gly Thr Gly Gly  Cys Thr Gly 
    4850                 4855                 4860             


Cys Ala  Ala Gly Thr Gly Gly  Ala Cys Thr Thr Cys  Cys Ala Gly 
    4865                 4870                 4875             


Ala Ala  Gly Ala Cys Ala Ala  Thr Gly Ala Ala Ala  Gly Thr Cys 
    4880                 4885                 4890             


Ala Cys  Ala Gly Gly Ala Gly  Thr Ala Ala Cys Thr  Ala Cys Thr 
    4895                 4900                 4905             


Cys Ala  Gly Gly Gly Ala Gly  Thr Ala Ala Ala Ala  Thr Cys Thr 
    4910                 4915                 4920             


Cys Thr  Gly Cys Thr Thr Ala  Cys Cys Ala Gly Cys  Ala Thr Gly 
    4925                 4930                 4935             


Thr Ala  Thr Gly Thr Gly Ala  Ala Gly Gly Ala Gly  Thr Thr Cys 
    4940                 4945                 4950             


Cys Thr  Cys Ala Thr Cys Thr  Cys Cys Ala Gly Cys  Ala Gly Thr 
    4955                 4960                 4965             


Cys Ala  Ala Gly Ala Thr Gly  Gly Cys Cys Ala Thr  Cys Ala Gly 
    4970                 4975                 4980             


Thr Gly  Gly Ala Cys Thr Cys  Thr Cys Thr Thr Thr  Thr Thr Thr 
    4985                 4990                 4995             


Cys Ala  Gly Ala Ala Thr Gly  Gly Cys Ala Ala Ala  Gly Thr Ala 
    5000                 5005                 5010             


Ala Ala  Gly Gly Thr Thr Thr  Thr Thr Cys Ala Gly  Gly Gly Ala 
    5015                 5020                 5025             


Ala Ala  Thr Cys Ala Ala Gly  Ala Cys Thr Cys Cys  Thr Thr Cys 
    5030                 5035                 5040             


Ala Cys  Ala Cys Cys Thr Gly  Thr Gly Gly Thr Gly  Ala Ala Cys 
    5045                 5050                 5055             


Thr Cys  Thr Cys Thr Ala Gly  Ala Cys Cys Cys Ala  Cys Cys Gly 
    5060                 5065                 5070             


Thr Thr  Ala Cys Thr Gly Ala  Cys Thr Cys Gly Cys  Thr Ala Cys 
    5075                 5080                 5085             


Cys Thr  Thr Cys Gly Ala Ala  Thr Thr Cys Ala Cys  Cys Cys Cys 
    5090                 5095                 5100             


Cys Ala  Gly Ala Gly Thr Thr  Gly Gly Gly Thr Gly  Cys Ala Cys 
    5105                 5110                 5115             


Cys Ala  Gly Ala Thr Thr Gly  Cys Cys Cys Thr Gly  Ala Gly Gly 
    5120                 5125                 5130             


Ala Thr  Gly Gly Ala Gly Gly  Thr Thr Cys Thr Gly  Gly Gly Cys 
    5135                 5140                 5145             


Thr Gly  Cys Gly Ala Gly Gly  Cys Ala Cys Ala Gly  Gly Ala Cys 
    5150                 5155                 5160             


Cys Thr  Cys Thr Ala Cys Thr  Gly Ala Gly Cys Thr  Cys Gly Ala 
    5165                 5170                 5175             


Gly Thr  Cys Thr Ala Gly Ala  Gly Gly Gly Cys Cys  Cys Gly Thr 
    5180                 5185                 5190             


Thr Thr  Ala Ala Ala Cys Cys  Cys Gly Cys Thr Gly  Ala Thr Cys 
    5195                 5200                 5205             


Ala Gly  Cys Cys Thr 
    5210             


<210>  4
<211>  1709
<212>  PRT
<213>  artificial sequence

<220>
<223>  chimeric factor VIII polypeptide having a length of 1709 amino 
       acids

<400>  4

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val 
    50                  55                  60                  


Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser 
65                  70                  75                  80  


Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg 
        195                 200                 205             


Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met 
225                 230                 235                 240 


Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His 
                325                 330                 335     


His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn 
        355                 360                 365             


Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Gly Arg 
        995                 1000                 1005             


Thr Glu  Arg Leu Cys Ser Gln  Asn Pro Pro Val Leu  Lys Arg His 
    1010                 1015                 1020             


Gln Arg  Glu Ile Thr Arg Thr  Thr Leu Gln Ser Asp  Gln Glu Glu 
    1025                 1030                 1035             


Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu Met Lys  Lys Glu Asp 
    1040                 1045                 1050             


Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe 
    1055                 1060                 1065             


Gln Lys  Arg Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Gln Leu 
    1070                 1075                 1080             


Trp Asp  Tyr Gly Met Ser Glu  Ser Pro Arg Ala Leu  Arg Asn Arg 
    1085                 1090                 1095             


Ala Gln  Asn Gly Glu Val Pro  Arg Phe Lys Lys Val  Val Phe Arg 
    1100                 1105                 1110             


Glu Phe  Ala Asp Gly Ser Phe  Thr Gln Pro Ser Tyr  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asn  Lys His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1130                 1135                 1140             


Val Glu  Asp Asn Ile Met Val  Thr Phe Lys Asn Gln  Ala Ser Arg 
    1145                 1150                 1155             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Pro  Asp Asp Gln 
    1160                 1165                 1170             


Glu Gln  Gly Ala Glu Pro Arg  His Asn Phe Val Gln  Pro Asn Glu 
    1175                 1180                 1185             


Thr Arg  Thr Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1190                 1195                 1200             


Glu Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1205                 1210                 1215             


Asp Leu  Glu Lys Asp Val His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1220                 1225                 1230             


Ile Cys  Arg Ala Asn Thr Leu  Asn Ala Ala His Gly  Arg Gln Val 
    1235                 1240                 1245             


Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1250                 1255                 1260             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Val Glu Arg Asn  Cys Arg Ala 
    1265                 1270                 1275             


Pro Cys  His Leu Gln Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr 
    1280                 1285                 1290             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1295                 1300                 1305             


Leu Val  Met Ala Gln Asn Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1310                 1315                 1320             


Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 
    1325                 1330                 1335             


Val Phe  Ser Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1340                 1345                 1350             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    1355                 1360                 1365             


Lys Val  Gly Ile Trp Arg Ile  Glu Cys Leu Ile Gly  Glu His Leu 
    1370                 1375                 1380             


Gln Ala  Gly Met Ser Thr Thr  Phe Leu Val Tyr Ser  Lys Lys Cys 
    1385                 1390                 1395             


Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 
    1400                 1405                 1410             


Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 
    1415                 1420                 1425             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    1430                 1435                 1440             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 
    1445                 1450                 1455             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    1460                 1465                 1470             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    1475                 1480                 1485             


Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    1490                 1495                 1500             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 
    1505                 1510                 1515             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 
    1520                 1525                 1530             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    1535                 1540                 1545             


Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 
    1550                 1555                 1560             


Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    1565                 1570                 1575             


Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser 
    1580                 1585                 1590             


Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 
    1595                 1600                 1605             


Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Val  Thr Thr Gln 
    1610                 1615                 1620             


Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 
    1625                 1630                 1635             


Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln 
    1640                 1645                 1650             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 
    1655                 1660                 1665             


Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    1670                 1675                 1680             


Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Met 
    1685                 1690                 1695             


Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu Tyr 
    1700                 1705                 


<210>  5
<211>  1467
<212>  PRT
<213>  artificial sequence

<220>
<223>  chimeric factor VIII polypeptide having a length of 1467 amino 
       acids

<400>  5

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu 
1               5                   10                  15      


Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val 
    50                  55                  60                  


Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser 
65                  70                  75                  80  


Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg 
        195                 200                 205             


Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met 
225                 230                 235                 240 


Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His 
                325                 330                 335     


His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn 
        355                 360                 365             


Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ala Gln Asn Ser Arg Pro Pro 
        755                 760                 765             


Ser Ala Ser Ala Pro Lys Pro Pro Val Leu Arg Arg His Gln Arg Asp 
    770                 775                 780                 


Ile Ser Leu Pro Thr Phe Gln Pro Glu Glu Asp Lys Met Asp Tyr Asp 
785                 790                 795                 800 


Asp Ile Phe Ser Thr Glu Thr Lys Gly Glu Asp Phe Asp Ile Tyr Gly 
                805                 810                 815     


Glu Asp Glu Asn Gln Asp Pro Arg Ser Phe Gln Lys Arg Thr Arg His 
            820                 825                 830         


Tyr Phe Ile Ala Ala Val Glu Gln Leu Trp Asp Tyr Gly Met Ser Glu 
        835                 840                 845             


Ser Pro Arg Ala Leu Arg Asn Arg Ala Gln Asn Gly Glu Val Pro Arg 
    850                 855                 860                 


Phe Lys Lys Val Val Phe Arg Glu Phe Ala Asp Gly Ser Phe Thr Gln 
865                 870                 875                 880 


Pro Ser Tyr Arg Gly Glu Leu Asn Lys His Leu Gly Leu Leu Gly Pro 
                885                 890                 895     


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys Asn 
            900                 905                 910         


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Pro 
        915                 920                 925             


Asp Asp Gln Glu Gln Gly Ala Glu Pro Arg His Asn Phe Val Gln Pro 
    930                 935                 940                 


Asn Glu Thr Arg Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
945                 950                 955                 960 


Thr Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
                965                 970                 975     


Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            980                 985                 990         


Cys Arg Ala Asn Thr Leu Asn Ala  Ala His Gly Arg Gln  Val Thr Val 
        995                 1000                 1005             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1010                 1015                 1020             


Trp Tyr  Phe Thr Glu Asn Val  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1025                 1030                 1035             


His Leu  Gln Met Glu Asp Pro  Thr Leu Lys Glu Asn  Tyr Arg Phe 
    1040                 1045                 1050             


His Ala  Ile Asn Gly Tyr Val  Met Asp Thr Leu Pro  Gly Leu Val 
    1055                 1060                 1065             


Met Ala  Gln Asn Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1070                 1075                 1080             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1085                 1090                 1095             


Ser Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Val  Tyr Asn Leu 
    1100                 1105                 1110             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Val 
    1115                 1120                 1125             


Gly Ile  Trp Arg Ile Glu Cys  Leu Ile Gly Glu His  Leu Gln Ala 
    1130                 1135                 1140             


Gly Met  Ser Thr Thr Phe Leu  Val Tyr Ser Lys Lys  Cys Gln Thr 
    1145                 1150                 1155             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1160                 1165                 1170             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1175                 1180                 1185             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1190                 1195                 1200             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1205                 1210                 1215             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1220                 1225                 1230             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1235                 1240                 1245             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1250                 1255                 1260             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1265                 1270                 1275             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1280                 1285                 1290             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1295                 1300                 1305             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1310                 1315                 1320             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1325                 1330                 1335             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1340                 1345                 1350             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1355                 1360                 1365             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1370                 1375                 1380             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1385                 1390                 1395             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1400                 1405                 1410             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1415                 1420                 1425             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1430                 1435                 1440             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1445                 1450                 1455             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1460                 1465         


<210>  6
<211>  579
<212>  PRT
<213>  Flavobacterium okeanokoites

<400>  6

Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln Asn Pro Gly Lys 
1               5                   10                  15      


Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp Arg Asn Ser Lys 
            20                  25                  30          


Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr Leu Val Lys Glu 
        35                  40                  45              


Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn Gln His Asp Leu 
    50                  55                  60                  


Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr Ser Ile Arg Ser 
65                  70                  75                  80  


Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile Ala Asp Gln Gly 
                85                  90                  95      


Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp Gly Phe Leu Arg 
            100                 105                 110         


Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn Lys Ser Asp Ser 
        115                 120                 125             


Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys Ser Ala Asp Gly 
    130                 135                 140                 


Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile Ser Ser Tyr Pro 
145                 150                 155                 160 


Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly Gln His Leu Thr 
                165                 170                 175     


Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly Glu Ser Gly Phe 
            180                 185                 190         


Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu Ala Asn Ala Met 
        195                 200                 205             


Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu Gly Ser Ser Asp 
    210                 215                 220                 


Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys Leu Gly Leu Val 
225                 230                 235                 240 


Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu Gly Lys Pro Asp 
                245                 250                 255     


Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr Gly Glu Gly Leu 
            260                 265                 270         


Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe Thr Arg Val Pro 
        275                 280                 285             


Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu Thr Asp Lys Glu 
    290                 295                 300                 


Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile Leu Ile Lys Ala 
305                 310                 315                 320 


Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu Lys Lys Leu Gly 
                325                 330                 335     


Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile Lys Gly Leu Ile 
            340                 345                 350         


Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe Tyr Gln Leu Lys 
        355                 360                 365             


Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly Val Thr Lys Gln 
    370                 375                 380                 


Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys 
385                 390                 395                 400 


Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg 
                405                 410                 415     


Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe 
            420                 425                 430         


Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys 
        435                 440                 445             


Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val 
    450                 455                 460                 


Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly 
465                 470                 475                 480 


Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn 
                485                 490                 495     


Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val 
            500                 505                 510         


Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr 
        515                 520                 525             


Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala 
    530                 535                 540                 


Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala 
545                 550                 555                 560 


Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu 
                565                 570                 575     


Ile Asn Phe 
            


<210>  7
<211>  195
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  7

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Lys Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn 
        195 


<210>  8
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  8

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  9
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  9

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  10
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  10

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn Arg Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  11
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  11

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asp Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  12
<211>  195
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  12

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Lys Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn 
        195 


<210>  13
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  13

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  14
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  14

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  15
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  catalytic domain

<400>  15

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asp Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  16
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = 2 amino acids, wherein X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = 2 or 4 amino acids, wherein X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = 12 amino acids, wherein X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = 3 or 4 or 5 amino acids, wherein X can be any amino acid

<400>  16

Xaa Cys Xaa Cys Xaa His Xaa His 
1               5               


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  17
cctgccttaa acccagccag                                                   20


<210>  18
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  18
atgacctcat gctcttggcc ctcgta                                            26


<210>  19
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  19
tcccctccca gaaagacctg c                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  20
tcccctccca gaaagacctg c                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  21
tacctaacgc actcctgggt ga                                                22


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  22
ttcgggtcac ctctcactcc                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  23
gacgcgcgtg aggaagagtt c                                                 21


<210>  24
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  24
aggcgcaccg tgggcttgt                                                    19


<210>  25
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  25
ctgtggaatg tgtgtcagtt ag                                                22


<210>  26
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  26
ggctccatcg taagcaaacc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  27
cgcctctgcc tctgagctat                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  28
cgagatgacc gagtacaag                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  29
gctcgtagaa ggggaggttg                                                   20


<210>  30
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  30
tcaccgagct gcaagaact                                                    19


<210>  31
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  31
atcctgtccc ta                                                           12


<210>  32
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  32
accccacagt gg                                                           12


<210>  33
<211>  574
<212>  PRT
<213>  human

<400>  33

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  34
<211>  161
<212>  PRT
<213>  human

<400>  34

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  35
<211>  658
<212>  PRT
<213>  human

<400>  35

Met Asp Arg Gly Thr Leu Pro Leu Ala Val Ala Leu Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Leu Ser Pro Thr Ser Leu Ala Glu Thr Val His Cys Asp Leu 
            20                  25                  30          


Gln Pro Val Gly Pro Glu Arg Gly Glu Val Thr Tyr Thr Thr Ser Gln 
        35                  40                  45              


Val Ser Lys Gly Cys Val Ala Gln Ala Pro Asn Ala Ile Leu Glu Val 
    50                  55                  60                  


His Val Leu Phe Leu Glu Phe Pro Thr Gly Pro Ser Gln Leu Glu Leu 
65                  70                  75                  80  


Thr Leu Gln Ala Ser Lys Gln Asn Gly Thr Trp Pro Arg Glu Val Leu 
                85                  90                  95      


Leu Val Leu Ser Val Asn Ser Ser Val Phe Leu His Leu Gln Ala Leu 
            100                 105                 110         


Gly Ile Pro Leu His Leu Ala Tyr Asn Ser Ser Leu Val Thr Phe Gln 
        115                 120                 125             


Glu Pro Pro Gly Val Asn Thr Thr Glu Leu Pro Ser Phe Pro Lys Thr 
    130                 135                 140                 


Gln Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala Ala 
145                 150                 155                 160 


Glu Leu Asn Asp Pro Gln Ser Ile Leu Leu Arg Leu Gly Gln Ala Gln 
                165                 170                 175     


Gly Ser Leu Ser Phe Cys Met Leu Glu Ala Ser Gln Asp Met Gly Arg 
            180                 185                 190         


Thr Leu Glu Trp Arg Pro Arg Thr Pro Ala Leu Val Arg Gly Cys His 
        195                 200                 205             


Leu Glu Gly Val Ala Gly His Lys Glu Ala His Ile Leu Arg Val Leu 
    210                 215                 220                 


Pro Gly His Ser Ala Gly Pro Arg Thr Val Thr Val Lys Val Glu Leu 
225                 230                 235                 240 


Ser Cys Ala Pro Gly Asp Leu Asp Ala Val Leu Ile Leu Gln Gly Pro 
                245                 250                 255     


Pro Tyr Val Ser Trp Leu Ile Asp Ala Asn His Asn Met Gln Ile Trp 
            260                 265                 270         


Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg 
        275                 280                 285             


Gly Phe Lys Leu Pro Asp Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg 
    290                 295                 300                 


Met Leu Asn Ala Ser Ile Val Ala Ser Phe Val Glu Leu Pro Leu Ala 
305                 310                 315                 320 


Ser Ile Val Ser Leu His Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr 
                325                 330                 335     


Ser Pro Ala Pro Ile Gln Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro 
            340                 345                 350         


Glu Leu Leu Met Ser Leu Ile Gln Thr Lys Cys Ala Asp Asp Ala Met 
        355                 360                 365             


Thr Leu Val Leu Lys Lys Glu Leu Val Ala His Leu Lys Cys Thr Ile 
    370                 375                 380                 


Thr Gly Leu Thr Phe Trp Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly 
385                 390                 395                 400 


Asp Lys Phe Val Leu Arg Ser Ala Tyr Ser Ser Cys Gly Met Gln Val 
                405                 410                 415     


Ser Ala Ser Met Ile Ser Asn Glu Ala Val Val Asn Ile Leu Ser Ser 
            420                 425                 430         


Ser Ser Pro Gln Arg Lys Lys Val His Cys Leu Asn Met Asp Ser Leu 
        435                 440                 445             


Ser Phe Gln Leu Gly Leu Tyr Leu Ser Pro His Phe Leu Gln Ala Ser 
    450                 455                 460                 


Asn Thr Ile Glu Pro Gly Gln Gln Ser Phe Val Gln Val Arg Val Ser 
465                 470                 475                 480 


Pro Ser Val Ser Glu Phe Leu Leu Gln Leu Asp Ser Cys His Leu Asp 
                485                 490                 495     


Leu Gly Pro Glu Gly Gly Thr Val Glu Leu Ile Gln Gly Arg Ala Ala 
            500                 505                 510         


Lys Gly Asn Cys Val Ser Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro 
        515                 520                 525             


Arg Phe Ser Phe Leu Leu His Phe Tyr Thr Val Pro Ile Pro Lys Thr 
    530                 535                 540                 


Gly Thr Leu Ser Cys Thr Val Ala Leu Arg Pro Lys Thr Gly Ser Gln 
545                 550                 555                 560 


Asp Gln Glu Val His Arg Thr Val Phe Met Arg Leu Asn Ile Ile Ser 
                565                 570                 575     


Pro Asp Leu Ser Gly Cys Thr Ser Lys Gly Leu Val Leu Pro Ala Val 
            580                 585                 590         


Leu Gly Ile Thr Phe Gly Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala 
        595                 600                 605             


Ala Leu Trp Tyr Ile Tyr Ser His Thr Arg Ser Pro Ser Lys Arg Glu 
    610                 615                 620                 


Pro Val Val Ala Val Ala Ala Pro Ala Ser Ser Glu Ser Ser Ser Thr 
625                 630                 635                 640 


Asn His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Thr Ser Ser 
                645                 650                 655     


Met Ala 
        


<210>  36
<211>  385
<212>  PRT
<213>  human

<400>  36

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  37
<211>  1304
<212>  PRT
<213>  human

<400>  37

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly 
            20                  25                  30          


Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu 
        35                  40                  45              


Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu 
    50                  55                  60                  


Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser 
65                  70                  75                  80  


Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr 
                85                  90                  95      


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
            100                 105                 110         


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
        115                 120                 125             


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
    130                 135                 140                 


Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
145                 150                 155                 160 


Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
                165                 170                 175     


Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
            180                 185                 190         


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
        195                 200                 205             


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
    210                 215                 220                 


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
225                 230                 235                 240 


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
                245                 250                 255     


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
            260                 265                 270         


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
        275                 280                 285             


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
    290                 295                 300                 


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
305                 310                 315                 320 


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
                325                 330                 335     


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
            340                 345                 350         


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
        355                 360                 365             


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
    370                 375                 380                 


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
385                 390                 395                 400 


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
                405                 410                 415     


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
            420                 425                 430         


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
        435                 440                 445             


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
    450                 455                 460                 


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
465                 470                 475                 480 


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
                485                 490                 495     


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
            500                 505                 510         


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
        515                 520                 525             


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
    530                 535                 540                 


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
545                 550                 555                 560 


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
                565                 570                 575     


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
            580                 585                 590         


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
        595                 600                 605             


Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
    610                 615                 620                 


Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
625                 630                 635                 640 


Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
                645                 650                 655     


Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
            660                 665                 670         


Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
        675                 680                 685             


Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
    690                 695                 700                 


Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
705                 710                 715                 720 


Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
                725                 730                 735     


Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
            740                 745                 750         


Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
        755                 760                 765             


Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
    770                 775                 780                 


Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
785                 790                 795                 800 


Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
                805                 810                 815     


Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
            820                 825                 830         


Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
        835                 840                 845             


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
    850                 855                 860                 


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
865                 870                 875                 880 


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
                885                 890                 895     


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
            900                 905                 910         


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
        915                 920                 925             


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
    930                 935                 940                 


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
945                 950                 955                 960 


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
                965                 970                 975     


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
            980                 985                 990         


Lys Glu Ser Glu His Asp Ser Asp  Glu Ser Ser Asp Asp  Asp Ser Asp 
        995                 1000                 1005             


Ser Glu  Glu Pro Ser Lys Tyr  Ile Asn Ala Ser Phe  Ile Met Ser 
    1010                 1015                 1020             


Tyr Trp  Lys Pro Glu Val Met  Ile Ala Ala Gln Gly  Pro Leu Lys 
    1025                 1030                 1035             


Glu Thr  Ile Gly Asp Phe Trp  Gln Met Ile Phe Gln  Arg Lys Val 
    1040                 1045                 1050             


Lys Val  Ile Val Met Leu Thr  Glu Leu Lys His Gly  Asp Gln Glu 
    1055                 1060                 1065             


Ile Cys  Ala Gln Tyr Trp Gly  Glu Gly Lys Gln Thr  Tyr Gly Asp 
    1070                 1075                 1080             


Ile Glu  Val Asp Leu Lys Asp  Thr Asp Lys Ser Ser  Thr Tyr Thr 
    1085                 1090                 1095             


Leu Arg  Val Phe Glu Leu Arg  His Ser Lys Arg Lys  Asp Ser Arg 
    1100                 1105                 1110             


Thr Val  Tyr Gln Tyr Gln Tyr  Thr Asn Trp Ser Val  Glu Gln Leu 
    1115                 1120                 1125             


Pro Ala  Glu Pro Lys Glu Leu  Ile Ser Met Ile Gln  Val Val Lys 
    1130                 1135                 1140             


Gln Lys  Leu Pro Gln Lys Asn  Ser Ser Glu Gly Asn  Lys His His 
    1145                 1150                 1155             


Lys Ser  Thr Pro Leu Leu Ile  His Cys Arg Asp Gly  Ser Gln Gln 
    1160                 1165                 1170             


Thr Gly  Ile Phe Cys Ala Leu  Leu Asn Leu Leu Glu  Ser Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Val Val Asp Ile  Phe Gln Val Val Lys  Ala Leu Arg 
    1190                 1195                 1200             


Lys Ala  Arg Pro Gly Met Val  Ser Thr Phe Glu Gln  Tyr Gln Phe 
    1205                 1210                 1215             


Leu Tyr  Asp Val Ile Ala Ser  Thr Tyr Pro Ala Gln  Asn Gly Gln 
    1220                 1225                 1230             


Val Lys  Lys Asn Asn His Gln  Glu Asp Lys Ile Glu  Phe Asp Asn 
    1235                 1240                 1245             


Glu Val  Asp Lys Val Lys Gln  Asp Ala Asn Cys Val  Asn Pro Leu 
    1250                 1255                 1260             


Gly Ala  Pro Glu Lys Leu Pro  Glu Ala Lys Glu Gln  Ala Glu Gly 
    1265                 1270                 1275             


Ser Glu  Pro Thr Ser Gly Thr  Glu Gly Pro Glu His  Ser Val Asn 
    1280                 1285                 1290             


Gly Pro  Ala Ser Pro Ala Leu  Asn Gln Gly Ser 
    1295                 1300                 


<210>  38
<211>  254
<212>  PRT
<213>  human

<400>  38

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


